nad has been researched along with spermidine in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (29.17) | 18.7374 |
| 1990's | 5 (20.83) | 18.2507 |
| 2000's | 5 (20.83) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 3 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, AC; Ferro, AM; Kun, E; Nitecki, D; Sharma, ML | 1 |
| Bacchi, CJ; Hutner, SH; Lambros, C; Marcus, SL | 1 |
| Kawamura, M; Shimoyama, M; Tanigawa, Y | 1 |
| Folk, JE; Park, MH; Wolff, EC | 1 |
| Cesarone, CF; Giannoni, P; Orunesu, M; Scarabelli, L | 1 |
| Chen, KY; Dou, QP | 1 |
| Park, MH; Wolff, EC | 1 |
| Padmanabhan, R; Tchen, TT | 1 |
| Kawamura, M; Kitamura, A; Miyake, Y; Shimoyama, M; Tanigawa, Y | 1 |
| Ishihara, T; Kondo, S; Naka, T; Shimizu, E; Yorifuji, T | 1 |
| Davies, DR; Liao, DI; Park, MH; Wolff, EC | 1 |
| Dimitriadis, EK; Joe, YA; Lee, YB; Park, MH; Wolff, EC | 1 |
| Lee, CH; Park, MH | 1 |
| Lee, CH; Park, MH; Um, PY | 1 |
| Folk, JE; Park, JH; Park, MH; Wolff, EC | 1 |
| Gottwald, A; Kaiser, A; Maier, W; Seitz, HM | 1 |
| Davies, DR; Park, MH; Umland, TC; Wolff, EC | 1 |
| Chery, A; Durand, S; Enot, DP; Galluzzi, L; Kroemer, G; Madeo, F; Niso-Santano, M; Pietrocola, F; Vacchelli, E | 1 |
| Bhardwaj, R; Dubey, VK; Kumar, R; Kumari, E; Singh, S | 1 |
| Mandal, A; Mandal, S; Park, MH; Wolff, EC | 1 |
| de Medina, P | 1 |
| Ambrus-Aikelin, G; Imamura, S; Kimura, H; Kitazawa, S; Klein, MG; Kurasawa, O; Matsumoto, S; Morishita, D; Ogawa, K; Okaniwa, M; Ono, K; Saito, B; Tanaka, Y; Uchiyama, N; Yokota, A | 1 |
| Chashmniam, S; Dalili, N; Kalantari, S; Nafar, M; Rezaie, D; Samavat, S | 1 |
| Chen, M; Gai, Z; Okada, C; Yao, M; Ye, Y; Yu, J | 1 |
24 other study(ies) available for nad and spermidine
| Article | Year |
|---|---|
Covalent modification of proteins by metabolites of NAD+.
Topics: Adenosine Diphosphate Sugars; Amino Acids; Animals; Chick Embryo; Deoxyribonucleases; Histones; NAD; Nucleoside Diphosphate Sugars; Pentosephosphates; Polylysine; Proteins; Ribosemonophosphates; Schiff Bases; Serum Albumin, Bovine; Spermidine; Spermine | 1976 |
Paradoxical activation of Leptomonas NAD-linked alpha-glycerophosphate dehydrogenase by ethidium and antrycide.
Topics: Animals; Dihydroxyacetone Phosphate; Enzyme Activation; Ethidium; Glycerolphosphate Dehydrogenase; Kinetics; Magnesium; Muscles; NAD; Quinolinium Compounds; Rabbits; Species Specificity; Spermidine; Trypanosoma | 1977 |
Effect of polyamines on ADP-ribosylation of nuclear proteins from rat liver.
Topics: Animals; Cell Nucleus; Edetic Acid; Histones; Liver; Magnesium; NAD; NAD+ Nucleosidase; Poly(ADP-ribose) Polymerases; Polyamines; Proteins; Putrescine; Rats; Spermidine; Spermine | 1976 |
Cleavage of spermidine as the first step in deoxyhypusine synthesis. The role of NAD.
Topics: Animals; Chromatography, Gel; Chromatography, Ion Exchange; Eukaryotic Translation Initiation Factor 5A; Kinetics; Lysine; Male; NAD; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Precursors; Rats; RNA-Binding Proteins; Spermidine; Testis | 1990 |
Differential assay and biological significance of poly(ADP-ribose) polymerase activity in isolated liver nuclei.
Topics: Animals; Biological Assay; Cell Nucleus; Deoxyribonuclease I; DNA; DNA Damage; Liver; Male; NAD; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred Strains; Sonication; Spermidine | 1990 |
NAD+ stimulated the spermidine-dependent hypusine formation on the 18 kDa protein in cytosolic lysates derived from NB-15 mouse neuroblastoma cells.
Topics: Animals; Cell Line; Cytosol; Lysine; Mice; Molecular Weight; NAD; Nerve Tissue Proteins; Neuroblastoma; Putrescine; Spermidine; Tritium | 1988 |
Cell-free synthesis of deoxyhypusine. Separation of protein substrate and enzyme and identification of 1,3-diaminopropane as a product of spermidine cleavage.
Topics: Animals; Cell Line; Cell-Free System; Chromatography, Ion Exchange; Cricetinae; Diamines; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Lysine; NAD; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine | 1988 |
Aminoaldehyde dehydrogenases from a Pseudomonas species grown on polyamines.
Topics: Aldehydes; Amines; Ammonium Sulfate; Centrifugation, Density Gradient; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Electrophoresis; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; NAD; NADP; Oxidoreductases; Polyamines; Pseudomonas; Putrescine; Spermidine | 1972 |
Effect of polyamines on purified poly(ADP-ribose) synthetase from rat liver nuclei.
Topics: Animals; Cell Nucleus; DNA; Dose-Response Relationship, Drug; Histones; Kinetics; Liver; Magnesium; NAD; NAD+ Nucleosidase; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Polyamines; Putrescine; Rats; Spermidine; Spermine | 1981 |
Action of polyamine aminotransferase on norspermidine.
Topics: Acrolein; Alanine; Allylamine; Arthrobacter; Biogenic Polyamines; Diamines; Kinetics; NAD; Pyruvic Acid; Spermidine; Transaminases | 1997 |
Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site.
Topics: Binding Sites; Crystallography, X-Ray; Humans; Hydrogen Bonding; Lysine; Models, Molecular; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Conformation; Protein Processing, Post-Translational; Protein Structure, Secondary; Recombinant Proteins; Spermidine | 1998 |
Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursor.
Topics: Cell Extracts; Chromatography, Affinity; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Guanine; Humans; Hydrogen-Ion Concentration; Molecular Weight; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Binding; Protein Precursors; Protons; Recombinant Fusion Proteins; RNA-Binding Proteins; Sequence Analysis; Spermidine; Temperature; Thermodynamics; Ultracentrifugation | 1999 |
Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates.
Topics: Binding Sites; Eukaryotic Initiation Factor-5; Humans; Hydrogen-Ion Concentration; Lysine; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Binding; Protein Precursors; Spermidine; Substrate Specificity; Time Factors | 2000 |
Structure-function studies of human deoxyhypusine synthase: identification of amino acid residues critical for the binding of spermidine and NAD.
Topics: Amino Acids; Binding Sites; Eukaryotic Initiation Factor-5; Humans; Kinetics; Mutagenesis, Site-Directed; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Spermidine; Structure-Activity Relationship | 2001 |
Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase.
Topics: Eukaryotic Translation Initiation Factor 5A; Humans; Hydrogen-Ion Concentration; Kinetics; Lysine; Models, Chemical; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Putrescine; RNA-Binding Proteins; Spermidine; Time Factors; Trichloroacetic Acid | 2003 |
Targeting enzymes involved in spermidine metabolism of parasitic protozoa--a possible new strategy for anti-parasitic treatment.
Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Animals; Antiparasitic Agents; Binding Sites; Conserved Sequence; Deoxyadenosines; DNA Primers; Drug Design; Enzyme Inhibitors; Eukaryota; Humans; Molecular Sequence Data; NAD; Oxidoreductases Acting on CH-NH Group Donors; Plasmodium; Sequence Alignment; Sequence Homology, Amino Acid; Spermidine | 2003 |
A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complex.
Topics: Alkyl and Aryl Transferases; Amino Acid Motifs; Binding Sites; Conserved Sequence; Crystallography, X-Ray; Dimerization; Electrons; Eukaryotic Translation Initiation Factor 5A; Guanine; Humans; Hydrogen-Ion Concentration; Ions; Models, Molecular; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Binding; Protein Conformation; Protein Structure, Secondary; RNA-Binding Proteins; Spermidine; X-Ray Diffraction | 2004 |
Metabolomic analyses reveal that anti-aging metabolites are depleted by palmitate but increased by oleate in vivo.
Topics: Aging; Amino Acids; Animals; Autophagy; Female; Liver; Mass Spectrometry; Metabolomics; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Myocardium; NAD; Oleic Acid; Palmitates; Phosphatidylinositol 3-Kinases; Principal Component Analysis; Signal Transduction; Spermidine; Spermine | 2015 |
Molecular events leading to death of Leishmania donovani under spermidine starvation after hypericin treatment.
Topics: Adenosine Triphosphate; Anthracenes; Gene Expression Regulation; Humans; Leishmania donovani; Leishmaniasis, Visceral; NAD; Perylene; Spermidine; Trypanocidal Agents | 2017 |
A new non-radioactive deoxyhypusine synthase assay adaptable to high throughput screening.
Topics: Biosynthetic Pathways; Enzyme Assays; Enzyme Inhibitors; Guanine; High-Throughput Screening Assays; Humans; Hydrogen-Ion Concentration; Kinetics; Luminescent Measurements; NAD; Oxidoreductases Acting on CH-NH Group Donors; Small Molecule Libraries; Spermidine; Substrate Specificity; Time Factors | 2017 |
Deciphering the metabolic secret of longevity through the analysis of metabolic response to stress on long-lived species.
Topics: Aging; Animals; Homeostasis; Humans; Longevity; Metabolomics; Mice; Models, Theoretical; Mole Rats; NAD; Neoplasms; Oxidative Stress; Rats; Resveratrol; Species Specificity; Spermidine; Stress, Physiological | 2019 |
Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase.
Topics: Allosteric Site; Crystallography, X-Ray; Drug Discovery; Enzyme Assays; Enzyme Inhibitors; Guanine; High-Throughput Screening Assays; Humans; Indoles; Molecular Structure; NAD; Oxidoreductases Acting on CH-NH Group Donors; Protein Binding; Protein Conformation; Spermidine; Structure-Activity Relationship; Thiophenes | 2020 |
A Noninvasive Urine Metabolome Panel as Potential Biomarkers for Diagnosis of T Cell-Mediated Renal Transplant Rejection.
Topics: Acute Disease; Adenosine Diphosphate; Adult; Biomarkers; Cholesterol Esters; Cross-Sectional Studies; Female; gamma-Aminobutyric Acid; Graft Rejection; Graft Survival; Hippurates; Humans; Kidney Transplantation; Male; Metabolome; Middle Aged; NAD; Niacin; Niacinamide; Proline; Renal Insufficiency, Chronic; ROC Curve; Spermidine; T-Lymphocytes | 2020 |
Flexible NAD
Topics: Binding Sites; Crystallography, X-Ray; Eukaryota; Lysine; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Conformation; Protein Processing, Post-Translational; Pyrococcus horikoshii; Spermidine | 2020 |