Page last updated: 2024-08-17

nad and ribavirin

nad has been researched along with ribavirin in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19908 (33.33)18.7374
1990's4 (16.67)18.2507
2000's10 (41.67)29.6817
2010's1 (4.17)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Goto, H; Ogasawara, N; Yamada, Y; Yoshino, M1
Natsumeda, Y; Pillwein, K; Weber, G1
Ahluwalia, GS; Cooney, DA; Dion, RL; Gebeyehu, G; Jayaram, HN; Johns, DG; Kelley, JA; Marquez, VE; Van Cott, A; Wilson, YA1
Kuttan, R; Saunders, P1
Berger, NA; Berger, SJ; Catino, DM; Petzold, SJ; Robins, RK1
Betts, CR; Cooney, DA; Gebeyehu, G; Jayaram, HN; Johns, DG; Kelley, JA; Marquez, VE1
Ahluwalia, GS; Cooney, DA; Dion, RL; Gebeyehu, G; Jayaram, HN; Johns, DG; Kelley, JA; Marquez, VE; Robins, RK1
Cooney, DA; Gebeyehu, G; Glazer, RI; Jayaram, HN; Johns, DG; Kelley, JA; Marquez, VE; Van Cott, AC; Zwelling, LA1
Faderan, MA; Liepnieks, JJ; Lui, MS; Weber, G1
Barzi, A; Cappellacci, L; Carrell, C; Franchetti, P; Goldstein, BM; Grifantini, M; Jayaram, HN; Nocentini, G; O'Connor, A; Yang, H1
Alvarez, E; Arimilli, S; Krohn, K; Muhs, MA; Saunders, PP; Surve-lyer, R1
Boulton, S; Durkacz, BW; Kyle, S1
Digits, JA; Hedstrom, L1
Goldstein, BM; Jayaram, HN; Lesiak-Watanabe, K; Pankiewicz, KW; Watanabe, KA1
Luecke, H; Prosise, GL1
Clark, JL; Lostia, S; Otto, MJ; Pankiewicz, KW; Patterson, SE; Stuyver, LJ; Watanabe, KA1
Black, PL; Goldstein, BM; Jayaram, HN; Pankiewicz, KW; Patterson, SE; Risal, D; Schinazi, RF; Stuyver, LJ1
Bieganowski, P; Brenner, C1
Cappellacci, L; Cimadamore, F; Franchetti, P; Magni, G; Orsomando, G; Petrelli, R; Scotti, S; Sorci, L1
Borchardt, RT; Cai, S; Kuczera, K; Li, QS; Schowen, RL1
Bennett, EM; Bonnac, L; Chen, L; Felczak, K; Gao, G; Hedstrom, L; Jayaram, HN; Pankiewicz, KW; Patterson, SE; Wilson, D1
Aldrich, C; Bennett, E; Cappellacci, L; Chen, L; Di Stefano, M; Felczak, K; Franchetti, P; Grifantini, M; Magni, G; Mazzola, F; Pankiewicz, KW; Petrelli, R; Sham, YY; Wilson, D; Yu, JS1
Blau, ME; Jenkins, JL; Srivastava, Y; Wedekind, JE1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1

Reviews

1 review(s) available for nad and ribavirin

ArticleYear
Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target.
    Current medicinal chemistry, 2004, Volume: 11, Issue:7

    Topics: Catalysis; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Molecular Mimicry; Molecular Structure; Mycophenolic Acid; NAD; Ribavirin; Ribonucleosides

2004

Other Studies

23 other study(ies) available for nad and ribavirin

ArticleYear
IMP dehydrogenase and action of antimetabolites in human cultured blast cells.
    Biochimica et biophysica acta, 1990, Mar-09, Volume: 1051, Issue:3

    Topics: Adenine Nucleotides; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Humans; IMP Dehydrogenase; Inosine Monophosphate; Ketone Oxidoreductases; Kinetics; Leukemia; NAD; Ribavirin; Ribonucleosides

1990
Targets and markers of selective action of tiazofurin.
    Advances in enzyme regulation, 1985, Volume: 24

    Topics: Adenine Nucleotides; Animals; Antineoplastic Agents; Guanine Nucleotides; IMP Dehydrogenase; Liver; Liver Neoplasms, Experimental; NAD; Phosphoribosyl Pyrophosphate; Rats; Rats, Inbred Strains; Ribavirin; Ribonucleosides

1985
Ribavirin, tiazofurin, and selenazofurin: mononucleotides and nicotinamide adenine dinucleotide analogues. Synthesis, structure, and interactions with IMP dehydrogenase.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:1

    Topics: Animals; IMP Dehydrogenase; Ketone Oxidoreductases; Kinetics; Leukemia P388; Mice; NAD; Organoselenium Compounds; Ribavirin; Ribonucleosides; Selenium

1985
Inhibitors of inosinate dehydrogenase.
    Biochemistry international, 1987, Volume: 14, Issue:2

    Topics: Allosteric Site; Animals; Binding Sites; Binding, Competitive; Cell Line; Cricetinae; Cricetulus; Female; Fibroblasts; IMP Dehydrogenase; Ketone Oxidoreductases; NAD; Ovary; Protein Binding; Ribavirin; Ribonucleotides

1987
Modulation of nicotinamide adenine dinucleotide and poly(adenosine diphosphoribose) metabolism by the synthetic "C" nucleoside analogs, tiazofurin and selenazofurin. A new strategy for cancer chemotherapy.
    The Journal of clinical investigation, 1985, Volume: 75, Issue:2

    Topics: Animals; Antineoplastic Agents; Cells, Cultured; Leukemia L1210; Mice; NAD; Nucleoside Diphosphate Sugars; Organoselenium Compounds; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Ribavirin; Ribonucleosides; Selenium

1985
The conversion of 2-beta-D-ribofuranosylthiazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties.
    Biochemical pharmacology, 1982, Jun-01, Volume: 31, Issue:11

    Topics: Adenosine; Animals; Antineoplastic Agents; IMP Dehydrogenase; Ketone Oxidoreductases; Kinetics; Leukemia P388; Male; Mice; NAD; Ribavirin; Ribonucleosides

1982
Conversion of 2-beta-D-ribofuranosylselenazole-4-carboxamide to an analogue of NAD with potent IMP dehydrogenase-inhibitory properties.
    Biochemical pharmacology, 1983, Sep-01, Volume: 32, Issue:17

    Topics: Animals; Gas Chromatography-Mass Spectrometry; IMP Dehydrogenase; Ketone Oxidoreductases; Leukemia P388; Leukemia, Experimental; Mice; NAD; Organoselenium Compounds; Ribavirin; Ribonucleosides; Selenium

1983
Studies on the mechanism of action of tiazofurin metabolism to an analog of NAD with potent IMP dehydrogenase-inhibitory activity.
    Advances in enzyme regulation, 1983, Volume: 21

    Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Guanosine Triphosphate; IMP Dehydrogenase; Ketone Oxidoreductases; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; NAD; Ribavirin; Ribonucleosides; Spectrophotometry

1983
Tiazofurin-induced selective depression of NAD content in hepatoma 3924A.
    Biochemical and biophysical research communications, 1984, Jul-18, Volume: 122, Issue:1

    Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Liver; Liver Neoplasms, Experimental; Male; NAD; Rats; Rats, Inbred ACI; Ribavirin; Ribonucleosides

1984
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
    Journal of medicinal chemistry, 1995, Sep-15, Volume: 38, Issue:19

    Topics: Animals; Antineoplastic Agents; Crystallography, X-Ray; Humans; IMP Dehydrogenase; Inosine Monophosphate; Magnetic Resonance Spectroscopy; Mice; NAD; Neoplasms; Ribavirin; Ribonucleosides; Ribonucleotides; Tumor Cells, Cultured

1995
Metabolism and action of benzamide riboside in Chinese hamster ovary cells.
    Anti-cancer drugs, 1996, Volume: 7, Issue:1

    Topics: Animals; Antineoplastic Agents; CHO Cells; Cricetinae; Drug Resistance; Enzyme Inhibitors; NAD; Nucleosides; Phosphorylation; Ribavirin

1996
Low nicotinamide mononucleotide adenylyltransferase activity in a tiazofurin-resistant cell line: effects on NAD metabolism and DNA repair.
    British journal of cancer, 1997, Volume: 76, Issue:7

    Topics: Animals; Antineoplastic Agents; Carcinogens; Cell Division; Dacarbazine; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Leukemia L1210; Methylnitronitrosoguanidine; Mice; NAD; Nicotinamide-Nucleotide Adenylyltransferase; Ribavirin; Temozolomide

1997
Drug selectivity is determined by coupling across the NAD+ site of IMP dehydrogenase.
    Biochemistry, 2000, Feb-22, Volume: 39, Issue:7

    Topics: Adenosine Diphosphate; Animals; Cricetinae; Cricetulus; Drug Resistance; Drug Synergism; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Mutagenesis, Site-Directed; Mycophenolic Acid; NAD; Ribavirin; Spectrometry, Fluorescence; Tritrichomonas foetus; Tryptophan

2000
The chemistry of nicotinamide adenine dinucleotide (NAD) analogues containing C-nucleosides related to nicotinamide riboside.
    Current medicinal chemistry, 2002, Volume: 9, Issue:7

    Topics: Antineoplastic Agents; Cell Survival; Humans; IMP Dehydrogenase; NAD; Niacinamide; Organoselenium Compounds; Pyridinium Compounds; Ribavirin; Ribonucleosides; Ribonucleotides; Tumor Cells, Cultured

2002
Crystal structures of Tritrichomonasfoetus inosine monophosphate dehydrogenase in complex with substrate, cofactor and analogs: a structural basis for the random-in ordered-out kinetic mechanism.
    Journal of molecular biology, 2003, Feb-14, Volume: 326, Issue:2

    Topics: Animals; Binding Sites; Catalysis; Crystallization; Crystallography, X-Ray; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Inosine Monophosphate; Kinetics; Models, Molecular; Mycophenolic Acid; NAD; Protein Conformation; Ribavirin; Ribonucleotides; Tritrichomonas foetus; Xanthine

2003
Inhibitors of the IMPDH enzyme as potential anti-bovine viral diarrhoea virus agents.
    Antiviral chemistry & chemotherapy, 2002, Volume: 13, Issue:6

    Topics: Animals; Cattle; Cell Line; Computer Systems; Culture Media, Conditioned; Diarrhea Viruses, Bovine Viral; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Guanosine Triphosphate; IMP Dehydrogenase; Kidney; Molecular Structure; Mycophenolic Acid; NAD; Nucleosides; Reverse Transcriptase Polymerase Chain Reaction; Ribavirin; Ribonucleosides; Viral Plaque Assay; Virus Replication

2002
Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans.
    Cell, 2004, May-14, Volume: 117, Issue:4

    Topics: Chromosomes, Human, Pair 9; Energy Metabolism; Evolution, Molecular; Fungi; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Humans; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; NAD; Niacinamide; Nucleosides; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds; Ribavirin; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid

2004
Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis.
    Biochemistry, 2007, Apr-24, Volume: 46, Issue:16

    Topics: Cell Line; Cell Line, Tumor; Chlorides; Humans; Isoenzymes; Kinetics; Magnesium Chloride; NAD; Niacinamide; Nicotinamide-Nucleotide Adenylyltransferase; Pyridinium Compounds; Ribavirin; Substrate Specificity; Zinc Compounds

2007
The antiviral drug ribavirin is a selective inhibitor of S-adenosyl-L-homocysteine hydrolase from Trypanosoma cruzi.
    Bioorganic & medicinal chemistry, 2007, Dec-01, Volume: 15, Issue:23

    Topics: Adenosylhomocysteinase; Animals; Antiviral Agents; Binding Sites; Chromatography, High Pressure Liquid; Drug Design; Enzyme Activation; Enzyme Inhibitors; Humans; Kinetics; Molecular Conformation; NAD; Recombinant Proteins; Ribavirin; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Time Factors; Trypanosoma cruzi

2007
Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues.
    Journal of medicinal chemistry, 2007, Nov-15, Volume: 50, Issue:23

    Topics: Adenosine Monophosphate; Antineoplastic Agents; Diphosphonates; Drug Screening Assays, Antitumor; Humans; IMP Dehydrogenase; Isoenzymes; K562 Cells; Models, Molecular; Mycophenolic Acid; NAD; Protein Binding; Ribavirin

2007
Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues.
    Bioorganic & medicinal chemistry, 2009, Aug-01, Volume: 17, Issue:15

    Topics: Adenosine; Binding Sites; Disulfides; Humans; Models, Molecular; Molecular Conformation; Mycobacterium tuberculosis; NAD; Phosphotransferases (Alcohol Group Acceptor); Ribavirin

2009
Full-Length NAD
    Biochemistry, 2023, Dec-05, Volume: 62, Issue:23

    Topics: Adenosine Triphosphate; Ligands; NAD; Nucleic Acid Conformation; Ribavirin; Riboswitch

2023
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010