Page last updated: 2024-08-17

nad and piperidines

nad has been researched along with piperidines in 116 studies

Research

Studies (116)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (9.48)	18.7374
1990's	4 (3.45)	18.2507
2000's	21 (18.10)	29.6817
2010's	71 (61.21)	24.3611
2020's	9 (7.76)	2.80

Authors

Authors	Studies
Iamkovoĭ, VI; Liakhovich, VV; Pospelova, LN; Tsyrlov, IB; Vaĭner, LM	1
Bragg, PD; Singh, AP	1
Calvert, AF; Rodwell, VW	1
Weiner, H	1
Mildvan, AS; Weiner, H	1
Balthasar, W	1
Ali, B; Dwivedi, C; Parmar, SS	1
Drott, HR; Santiago, D; Shore, JD	1
Andree, PJ; Zantema, A	1
Chibrikin, VM; Elek, G; Grigorian, GL; Keleti, T; Sajgó, M	1
Cornatzer, WE; Dwivedi, C; Gupta, AK; Gupta, TK; Parmar, SS	1
Plapp, BV; Ramaswamy, S; Scholze, M	1
Bao, J; Dawson, TM; Dawson, VL; Eliasson, MJ; Hurn, PD; Mandir, AS; Pieper, A; Sampei, K; Snyder, SH; Traystman, RJ; Wang, ZQ	1
de La Fuente, JL; Liras, P; Martín, JF; Rumbero, A	1
Kawanishi, S; Ohkuma, Y	1
Farkas, B; Literati-Nagy, P; Sumegi, B; Szabados, E	1
Berente, Z; Halmosi, R; Literati-Nagy, P; Osz, E; Sumegi, B; Toth, K	1
Kawanishi, S; Ohnishi, S	1
Asakura, S; Caldecott, KW; de Murcia, G; Hester, SD; Nakamura, J; Swenberg, JA	1
Hasmann, M; Schemainda, I	1
Antelava, AV; Chikobava, EA; Galenko-Yaroshevskii, VP; Meladze, VN; Popkov, VL; Sukoyan, GV; Zadorozhnyi, AV	1
Alfieri, AA; Chen, Y; Hasmann, M; Koutcher, JA; Matei, C; Muruganandham, M; Saltz, LB; Schemainda, I; Sukenick, G	1
Azzam, K; Hasmann, M; Nüssler, V; Pelka-Fleischer, R; Pogrebniak, A; Schemainda, I	1
Forouhar, F; Khan, JA; Tao, X; Tong, L	1
Burk, K; Hanauske, AR; Holen, K; Hollywood, E; Saltz, LB	1
Billington, RA; Canonico, PL; Condorelli, F; Ercolano, E; Galli, U; Genazzani, AA; Grolla, AA; Roman, CB; Travelli, C	1
Björkling, F; Christensen, MK; Jäättelä, M; Jensen, PB; Nielsen, SJ; Olesen, UH; Sehested, M	1
Billington, RA; Condorelli, F; Genazzani, AA; Travelli, C	1
Billington, RA; Blasi Roman, CR; Canonico, PL; Carraro, L; Ercolano, E; Galli, U; Genazzani, AA; Sorba, G; Tron, GC	1
Burgos, ES; Schramm, VL	1
Attinger, A; Aubry, D; Dawson, KM; Duchosal, MA; Dupuis, M; Greaney, P; Ireson, C; Nahimana, A; Thougaard, AV; Tjørnelund, J	1
Astarita, G; Kaluzova, M; Nakahata, Y; Sahar, S; Sassone-Corsi, P	1
Abrassart, D; Bass, J; Brace, CS; Buhr, ED; Chong, JL; Hong, HK; Imai, S; Kobayashi, Y; Lee, C; Marcheva, B; Ramsey, KM; Takahashi, JS; Yoshino, J	1
Wijnen, H	1
Chiarugi, A; Formentini, L; Moroni, F	1
Berglund, A; Larsson, R; Nygren, P; von Heideman, A	1
Ballestrero, A; Benvenuto, F; Bruzzone, S; Cea, M; D'Urso, A; Ferrando, T; Fruscione, F; Garuti, A; Moran, E; Morando, S; Mostoslavsky, R; Nencioni, A; Patrone, F; Poggi, A; Selmo, M; Soncini, D; Sordat, B; Uccelli, A; Zoppoli, G	1
Jensen, PB; Olesen, UH; Sehested, M; Thougaard, AV	1
Bi, TQ; Che, XM	1
Ballestrero, A; Bedognetti, D; Belka, C; Bruzzone, S; Caffa, I; Cea, M; Ferrando, F; Fruscione, F; Ghio, R; Moran, E; Motta, G; Nencioni, A; Parodi, S; Patrone, F; Rudner, J; Soncini, D; Zoppoli, G	1
Chiarugi, A; Cialdai, F; Faraco, G; Formentini, L; Lapucci, A; Moneti, G; Moroni, F; Pittelli, M; Rapizzi, E; Romano, G	1
Brown, AR; Goellner, EM; Grimme, B; Lin, YC; Mitchell, L; Sobol, RW; Sugrue, KF; Tang, JB; Trivedi, RN; Wang, XH	1
Ansaldi, F; Ballestrero, A; Bergamaschi, M; Bruzzone, S; Caffa, I; Cagnetta, A; Casciaro, S; Cea, M; Damonte, G; Emionite, L; Fruscione, F; Garuti, A; Gobbi, M; Magnone, M; Moran, E; Nencioni, A; Patrone, F; Pierri, I; Pistoia, V; Raffaghello, L; Reverberi, D; Salis, A; Soncini, D; Zoppoli, G	1
Ceglarek, U; Hauschildt, S; Klein, C; Raulien, N; Schilling, E; Wehrhahn, J	1
Bi, J; Ding, S; Li, H; Ye, SQ	1
Fang, SH; Hu, H; Ling, KN; Liu, LY; Lu, YB; Qie, LL; Wang, F; Wei, EQ; Xu, LH; Zhang, LY; Zhang, WP	1
Chandra, P; Dittrich, T; Lippka, Y; Skokowa, J; Thakur, BK; Welte, K	1
Akhmedov, A; Bauer, I; Bertolotto, M; Braunersreuther, V; Bruzzone, S; Dallegri, F; Galan, K; Garuti, A; Gayet-Ageron, A; Lenglet, S; Lerch, R; Lüscher, TF; Mach, F; Mage, J; Mannino, E; Montecucco, F; Montessuit, C; Mostoslavsky, R; Nencioni, A; Patrone, F; Pelli, G; Pellieux, C; Poggi, A; Sebastian, C; Speer, T; Vuilleumier, N	1
Bauer, I; Brini, M; Bruzzone, S; De Flora, A; Magnone, M; Mannino, E; Nencioni, A; Poggi, A; Sturla, L; Zocchi, E	1
Camacho-Pereira, J; Chini, CC; Chini, EN; Escande, C; Giri, S; Lou, Z; Matalonga, J; Nin, V	1
Huang, GZ; Woolley, CS	1
Becker, A; Chandra, P; Dittrich, T; Klusmann, JH; Kuehnau, W; Reinhardt, D; Thakur, BK; Welte, K	1
Anderson, KC; Cagnetta, A; Calimeri, T; Cea, M; Chauhan, D; Cottini, F; Fulciniti, M; Gobbi, M; Hideshima, T; Jakubikova, J; Kong, SY; Munshi, N; Nencioni, A; Patrone, F; Richardson, P; Roccaro, A; Sacco, A; Tai, YT	1
Huang, P; Liu, LY; Lu, YB; Wang, F; Wei, EQ; Zhang, WP; Zhang, XY	1
Dudley, SC; Efimov, IR; Greener, I; Gu, L; Jeong, EM; Liu, H; Liu, M; Sulkin, MS; Xie, A	1
Anderson, KC; Cagnetta, A; Cea, M; Gobbi, M; Nencioni, A; Patrone, F	1
Burkholder, TP; Geeganage, S; Gillig, J; Huss, K; Kuo, MS; Lu, ZH; Meier, TI; Parthasarathy, S; Roth, K; Shepard, RL; Smith, MC; Tan, B; Wang, T; Young, DA; Zhai, Y; Zhao, G	1
Felding-Habermann, B; Gay, LJ; LeBoeuf, SE; Matsuno-Yagi, A; Ritland, M; Santidrian, AF; Seo, BB; Yagi, T	1
Bam, R; Barlogie, B; Epstein, J; Khan, S; Li, X; Ling, W; Usmani, S; van Rhee, F; Venkateshaiah, SU; Yaccoby, S	1
Acharya, C; Anderson, KC; Cagnetta, A; Calimeri, T; Cea, M; Chauhan, D; Fulciniti, M; Gobbi, M; Hideshima, T; Munshi, N; Nencioni, A; Patrone, F; Richardson, P; Tai, YT; Zhong, MY	1
Bruzzone, S; Caffa, I; De Flora, A; Grozio, A; Nencioni, A; Raffaelli, N; Salis, A; Sociali, G; Soncini, D; Sturla, L	1
Sokabe, M; Tanaka, M	1
Barbosa, MT; Camacho-Pereira, J; Chini, CC; Chini, EN; Escande, C; Guerrico, AM; Nin, V	1
Cantley, LC; Lyssiotis, CA	1
Fukuwatari, T; Ito, M; Kaneko, I; Kido, S; Miyagawa, A; Miyamoto, K; Nomura, K; Sano, M; Sasaki, S; Segawa, H; Shibata, K; Shiozaki, Y; Tatsumi, S	1
Amedei, A; Cavone, L; Chiarugi, A; Felici, R; Lapucci, A; Niccolai, E; Oteri, C; Pittelli, M	1
Aubry, D; Breton, CS; Duchosal, MA; Majjigapu, SR; Nahimana, A; Sordat, B; Vogel, P	1
Benito-Martin, A; Carrasco, S; Egido, J; Izquierdo, MC; Lorenzo, O; Ortiz, A; Picatoste, B; Ruiz-Ortega, M; Santamaria, B; Ucero, AC	1
Floot, B; van Triest, B; Vens, C; Verheij, M; Zerp, SF	1
Aubry, D; Breton, C; Bruzzone, S; Cloux, AJ; Duchosal, MA; Ginet, V; Majjigapu, SR; Nahimana, A; Nencioni, A; Puyal, J; Rummel, C; Sordat, B; Vogel, P	1
Camp, SM; Deaton, R; Gann, PH; Garcia, JG; Letsiou, E; Ma, W; Machado, RF; Messana, J; Moreno-Vinasco, L; Quijada, H; Saadat, L; Sammani, S; Siegler, J; Wang, T; Zaidi, RS	1
Dölle, C; Skoge, RH; Ziegler, M	1
Fransen, JA; Oerlemans, FT; Venter, G; Wieringa, B; Wijers, M; Willemse, M	1
Andrabi, SA; Chang, C; Dawson, TM; Dawson, VL; Gagné, JP; Karuppagounder, SS; Poirier, GG; Stevens, DA; Umanah, GK	1
Chang, YZ; Chen, MY; Hu, ML; Song, TY; Yang, NC	1
Ai, Y; Jia, SH; Marshall, JC; Parodo, J; Peng, Q	1
Jiang, WX; Lu, JT; Lu, YB; Tang, C; Wei, EQ; Wu, M; Zhang, WP; Zhang, XQ	1
Chessler, SD; Chi, NW; Hao, J; Mahata, SK; Pourtabatabaei, N; Shao, J; Yeh, TY; Zhong, L	1
Dong, S; Geeganage, S; Kays, L; Kuo, MS; Roth, KD; Shepard, RL; Tan, B; Zhao, G	1
Acharya, C; Acharya, P; Adamia, S; Ballestrero, A; Bergamaschi, M; Bruzzone, S; Caffa, I; Cagnetta, A; Cea, M; Damonte, G; Fraternali, G; Garuti, A; Gobbi, M; Mastracci, L; Montecucco, F; Nencioni, A; Patrone, F; Pierri, I; Provenzani, A; Salis, A; Soncini, D; Zucal, C	1
Lavandero, S; López-Crisosto, C; Oyarzún, AP; Parra, V; Pedrozo, Z; Pennanen, C; Sánchez, G; Sotomayor-Flores, C; Troncoso, R; Westermeier, F	1
Chen, MY; Hu, ML; Song, TY; Yang, NC; Yeh, SL	1
Ballestrero, A; Caffa, I; Casini, A; Cea, M; D'Agostino, VG; Indraccolo, S; Mantelli, B; Nencioni, A; Provenzani, A; Quattrone, A; Soncini, D; Thongon, N; Zucal, C	1
Choi, KY; Hong, SM; Im, SH; Kim, KT; Kim, SW; Nam, YJ; Park, CW; Shin, JH; Sung, YC; Yu, JH; Yun, CH	1
Chen, D; Di Cresce, C; Ferguson, PJ; Figueredo, R; Koropatnick, J; Maleki Vareki, S; Min, W; Pampillo, M; Rytelewski, M; Vincent, M; Zheng, X	1
Lu, YB; Shi, QJ; Wei, EQ; Wu, M; Yang, P; Zhang, L; Zhang, WP	1
Bianchi, G; Bruzzone, S; Emionite, L; Magnone, M; Nahimana, A; Nencioni, A; Raffaelli, N; Raffaghello, L; Sociali, G; Sturla, L; Vigliarolo, T; Zamporlini, F	1
Chiao, PJ; Fan, XQ; Ju, HQ; Li, H; Lu, YX; Mo, HY; Sheng, H; Tian, T; Xu, RH; Zhou, HJ; Zhuang, ZN	1
Abramov, AY; Delgado-Camprubi, M; Esteras, N; Plun-Favreau, H; Soutar, MP	1
Alonso, J; Aryee, DNT; Ban, J; Banerji, V; Bouchard, EDJ; Garten, A; Hatch, GM; Katschnig, AM; Kauer, MO; Kovar, H; Mejia, EM; Mutz, CN; Schwentner, R	1
Deng, KY; Guan, XH; Hu, L; Huang, CC; Qian, YS; Wang, LF; Wang, XN; Xiao, YF; Xin, HB	1
Batchelor, TT; Cahill, DP; Chi, AS; Fisher, DE; Higuchi, F; Iafrate, AJ; Koerner, MVA; Lelic, N; Miller, JJ; Shankar, GM; Tanaka, S; Tateishi, K; Wakimoto, H	1
Li, D; Li, L; Lv, C; Xu, R; Yang, L; Yuan, Z	1
Alaee, M; Behrouzfar, K; Gholinejad, Z; Golestani, A; Nourbakhsh, M	1
Adolph, TE; Arnhard, K; Baier, G; Gerner, RR; Grander, C; Hermann-Kleiter, N; Klepsch, V; Macheiner, S; Moschen, AR; Moser, P; Oberacher, H; Pfister, A; Tilg, H; Wieser, V	1
Garten, A; Gebhardt, R; Gorski, T; Kiess, W; Penke, M; Schuster, S	1
Baczkó, I; Blanc, J; Brenner, C; Breton, M; Decaux, JF; Deloux, R; Diguet, N; Garnier, A; Gouge, A; Gressette, M; Lavery, GG; Li, Z; Manoury, B; Mericskay, M; Mougenot, N; Piquereau, J; Tannous, C; Trammell, SAJ; Zoll, J	1
Deng, H; Hu, Y; Wang, Q; Wang, W; Wang, X	1
Beg, MS; Hosein, AN	1
Bartoli, M; Fuller, J; Jadeja, RN; Jones, MA; Joseph, E; Martin, PM; Powell, FL; Thounaojam, MC	1
Deng, H; Hu, Y; Wang, W; Wang, X; Yang, C; Zhang, Z; Zhu, S	1
Bowlby, SC; Chmielewski, JP; Cramer, SD; D'Agostino, RB; Davis, AL; Howard, TD; Kridel, SJ; Miller, LD; Shi, L; Sirintrapun, SJ; Sui, G; Wheeler, FB	1
Brenner, C; Cambronne, XA; Cohen, MS; Goodman, RH; Liu, HW; Migaud, ME; Schmidt, MS; Smith, CB	1
Bellanger, S; Chin, T; Oblong, JE; Quek, LS; Rovito, HA; Tan, CL; Tan, CYR	1
Buescher, JM; Cameron, AM; Castoldi, A; Field, CS; Flachsmann, LJ; Hässler, F; Kelly, B; Kyle, RL; Patterson, AE; Pearce, EJ; Pearce, EL; Puleston, DJ; Sanin, DE	1
Haluzik, M; Kizek, R; Knejzlik, Z; Krizova, E; Krizova, I; Rayova, D; Rimpelova, S; Rumlova, M; Sestakova, S; Skop, V; Svoboda, P; Sykora, D; Vapenkova, K; Volfova, N; Zidek, V; Zidkova, J	1
Chen, C; Hu, Y; Huang, X; Shen, D; Xing, S	1
Ito, K; Ito, S; Kawai, M; Kudo, K; Morita, M; Nomura, M; Sakamoto, Y; Shima, H; Tanuma, N; Yaegashi, N; Yamada, H; Yamashita, Y	1
Elnenaei, MO; Gujar, SA; Kennedy, BE; Reiman, A; Sadek, M	1
Effenberger, M; Gerner, RR; Grabherr, F; Kircher, B; Macheiner, S; Mayr, L; Moschen, AR; Moser, P; Nachbaur, D; Oberacher, H; Reider, S; Schwaighofer, H; Siegmund, K; Texler, B; Tilg, H; Zeiser, R	1
Chen, J; Guo, C; Li, X; Qi, L; Wang, J; Ye, C; Yu, J; Zheng, S; Zhou, B	1
Alhumaydhi, FA; Aljohani, ASM; Bordin, DL; Charlier, CF; de O Lopes, D; Elliott, RM; Henriques, JAP; Lloyd, CB; McNicholas, MD; Meira, LB; Milano, L; Plant, KE; Villela, I	1
Estes, VM; Langelier, MF; Lee, BJ; Lin, X; Pascal, JM; Rouleau-Turcotte, É; Shao, Z; Zha, S	1
Cahill, DP; Kirtane, AR; Kiyokawa, J; Lee, CK; Li, M; Lopes, A; Nagashima, H; Tirmizi, ZA; Traverso, G; Wakimoto, H	1
Bovée, JVMG; Bruijn, IB; Cleton-Jansen, AM; Franceschini, N; Kruisselbrink, AB; Niessen, B; Oosting, J; Palubeckaitė, I; Tamsma, M; van den Akker, B	1
Lan, J; Lei, Y; Mao, Y; Quan, H; Xie, H; Yang, J; Zhang, T	1

Reviews

3 review(s) available for nad and piperidines

Article	Year
Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery. Expert opinion on therapeutic targets, 2007, Volume: 11, Issue:5 Topics: Acrylamides; Adenosine Diphosphate Ribose; Aging; Animals; Antineoplastic Agents; Autoimmune Diseases; Clinical Trials, Phase II as Topic; Cyclic ADP-Ribose; DNA Damage; Drug Design; Enzyme Inhibitors; Humans; Kynurenine; Mice; NAD; Neoplasms; Neurodegenerative Diseases; Neuroprotective Agents; Piperidines; Poly Adenosine Diphosphate Ribose; Signal Transduction; Sirtuins; Tryptophan	2007
Nampt/PBEF/visfatin and cancer. Cancer biology & therapy, 2010, Jul-15, Volume: 10, Issue:2 Topics: Acrylamides; Cytokines; Disease Progression; Humans; NAD; Neoplasms; Nicotinamide Phosphoribosyltransferase; Piperidines; Signal Transduction	2010
Pancreatic Cancer Metabolism: Molecular Mechanisms and Clinical Applications. Current oncology reports, 2018, 05-11, Volume: 20, Issue:7 Topics: Acrylamides; Adenocarcinoma; Antineoplastic Agents; Citric Acid Cycle; Glutaminase; Glutamine; Humans; Mitochondria; Molecular Targeted Therapy; NAD; NAD(P)H Dehydrogenase (Quinone); Pancreatic Neoplasms; Piperidines	2018

Trials

2 trial(s) available for nad and piperidines

Article	Year
The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor. Investigational new drugs, 2008, Volume: 26, Issue:1 Topics: Acrylamides; Adult; Aged; Area Under Curve; Dose-Response Relationship, Drug; Fatigue; Female; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; NAD; Nausea; Neoplasms; Neutropenia; Nicotinamide Phosphoribosyltransferase; Piperidines; Thrombocytopenia; Vascular Endothelial Growth Factor A; Vomiting	2008
Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data. Cancer chemotherapy and pharmacology, 2010, Volume: 65, Issue:6 Topics: Acrylamides; Aged; Clinical Trials, Phase I as Topic; Cyanides; Dose-Response Relationship, Drug; Drug Administration Schedule; Fatigue; Female; Guanidines; Humans; Male; Meta-Analysis as Topic; Middle Aged; NAD; Nausea; Neoplasms; Nicotinamide Phosphoribosyltransferase; Piperidines; Thrombocytopenia; Treatment Outcome; Vomiting	2010

Article

Year

The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor.

Investigational new drugs, 2008, Volume: 26, Issue:1

Topics: Acrylamides; Adult; Aged; Area Under Curve; Dose-Response Relationship, Drug; Fatigue; Female; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; NAD; Nausea; Neoplasms; Neutropenia; Nicotinamide Phosphoribosyltransferase; Piperidines; Thrombocytopenia; Vascular Endothelial Growth Factor A; Vomiting

2008

Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data.

Cancer chemotherapy and pharmacology, 2010, Volume: 65, Issue:6

Topics: Acrylamides; Aged; Clinical Trials, Phase I as Topic; Cyanides; Dose-Response Relationship, Drug; Drug Administration Schedule; Fatigue; Female; Guanidines; Humans; Male; Meta-Analysis as Topic; Middle Aged; NAD; Nausea; Neoplasms; Nicotinamide Phosphoribosyltransferase; Piperidines; Thrombocytopenia; Treatment Outcome; Vomiting

2010

Other Studies

111 other study(ies) available for nad and piperidines

Article	Year
[Cytochrome P-450 catalyzed oxidation of 1-piperidinoanthraquinone]. Biokhimiia (Moscow, Russia), 1979, Volume: 44, Issue:4 Topics: Animals; Anthraquinones; Carbon Monoxide; Catalysis; Cytochrome P-450 Enzyme System; Deoxycholic Acid; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Phenobarbital; Piperidines; Rats; Spectrum Analysis	1979
Reduced nicotinamide adenine dinucleotide dependent reduction of fumarate coupled to membrane energization in a cytochrome deficient mutant of Escherichia coli K12. Biochimica et biophysica acta, 1975, Aug-11, Volume: 396, Issue:2 Topics: Aminolevulinic Acid; Cell Membrane; Chelating Agents; Cytochromes; Dicumarol; Escherichia coli; Fumarates; Glycerol; Glycerolphosphate Dehydrogenase; Glycerophosphates; Hydroxyquinolines; NAD; NADH, NADPH Oxidoreductases; Nitrates; Piperidines; Quinones; Spectrometry, Fluorescence	1975
Metabolism of pipecolic acid in a Pseudomonas species. 3. L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase. The Journal of biological chemistry, 1966, Jan-25, Volume: 241, Issue:2 Topics: Adipates; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; NAD; Oxidoreductases; Piperidines; Pseudomonas	1966
Interaction of a spin-labeled analog of nicotinamide-adenine dinucleotide with alcohol dehydrogenase. I. Synthesis, kinetics, and electron paramagnetic resonance studies. Biochemistry, 1969, Volume: 8, Issue:2 Topics: Acetaldehyde; Adenine Nucleotides; Alcohol Oxidoreductases; Amines; Animals; Binding Sites; Chemical Phenomena; Chemistry; Electron Spin Resonance Spectroscopy; Ethanol; Free Radicals; Horses; Kinetics; Liver; NAD; Nucleotides; Phenanthrolines; Piperidines	1969
Interaction of a spin-labeled analog of nicotinamide-adenine dinucleotide with alcohol dehydrogenase. II. Proton relaxation rate and electron paramagnetic resonance studies of binary and ternary complexes. Biochemistry, 1969, Volume: 8, Issue:2 Topics: Adenine Nucleotides; Alcohol Oxidoreductases; Animals; Binding Sites; Chemical Phenomena; Chemistry; Computers; Electron Spin Resonance Spectroscopy; Free Radicals; Horses; NAD; Phenanthrolines; Piperidines; Protein Binding; Protons; Thermodynamics; Water	1969
Spin labeling studies of D-glyceraldehyde-3-phosphate dehydrogenase. European journal of biochemistry, 1971, Sep-24, Volume: 22, Issue:2 Topics: Acetamides; Animals; Binding Sites; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radicals; Glyceraldehyde-3-Phosphate Dehydrogenases; Iodoacetates; Muscles; NAD; Piperidines; Protein Binding; Rabbits	1971
Substituted carbamides: interrelationship between anticonvulsant activity and inhibition of nicotinamide adenine dinucleotide-dependent pyruvic acid oxidation. Journal of pharmaceutical sciences, 1972, Volume: 61, Issue:9 Topics: Acetates; Amides; Animals; Anticonvulsants; Brain; Carbamates; Chlorine; Enzyme Repression; Mice; Morphine; NAD; Oxidation-Reduction; Oxygen Consumption; Piperidines; Pyrrolidinones; Pyruvate Oxidase; Pyruvates; Rats; Structure-Activity Relationship	1972
Electron paramagnetic resonance study of the interaction of a spin-labeled analog of adenosine diphosphoribose with paramagnetic cobalt(II) liver alcohol dehydrogenase. FEBS letters, 1974, Feb-01, Volume: 39, Issue:1 Topics: Adenosine Diphosphate; Alcohol Oxidoreductases; Animals; Binding Sites; Cobalt; Electron Spin Resonance Spectroscopy; Liver; Mathematics; NAD; Nucleoside Diphosphate Sugars; Oxidation-Reduction; Piperidines; Protein Binding; Protein Conformation; Pyrazoles; Ribose; Spectrometry, Fluorescence; Spectrophotometry, Atomic; Spectrophotometry, Ultraviolet; Spin Labels; Temperature; Time Factors; Zinc	1974
Magnetic resonance studies on glutamate dehydrogenase. FEBS letters, 1974, Mar-15, Volume: 40, Issue:1 Topics: Adenosine Diphosphate; Binding Sites; Deuterium; Electron Spin Resonance Spectroscopy; Glutamate Dehydrogenase; Guanine Nucleotides; Iodoacetates; Ketoglutaric Acids; Kinetics; Magnetic Resonance Spectroscopy; Molecular Conformation; NAD; Oxidation-Reduction; Piperidines; Protein Binding; Protein Conformation; Spin Labels	1974
Spin labelling of D-glyceraldehyde-3-phosphate dehydrogenase with specific reagents. Acta biochimica et biophysica; Academiae Scientiarum Hungaricae, 1972, Volume: 7, Issue:2 Topics: Amino Acid Sequence; Animals; Binding Sites; Carbon Radioisotopes; Cysteine; Electron Spin Resonance Spectroscopy; Evaluation Studies as Topic; Glyceraldehyde-3-Phosphate Dehydrogenases; Iodoacetates; Methods; Muscles; NAD; Piperidines; Protein Binding; Protein Conformation; Spin Labels; Sulfhydryl Compounds; Swine; Time Factors	1972
Synthesis of substituted piperidino carbamides: correlation between CNS effects and selective inhibition of NAD-dependent oxidations. Journal of pharmaceutical sciences, 1974, Volume: 63, Issue:8 Topics: Amides; Animals; Anticonvulsants; Brain; Drug Synergism; In Vitro Techniques; Ketoglutaric Acids; Lethal Dose 50; Male; NAD; Oxidation-Reduction; Pentobarbital; Pentylenetetrazole; Piperidines; Pyruvates; Rats; Seizures; Sleep; Succinates; Time Factors	1974
Binding of formamides to liver alcohol dehydrogenase. Biochemistry, 1997, Mar-25, Volume: 36, Issue:12 Topics: Alcohol Dehydrogenase; Animals; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Formamides; Horses; Isoenzymes; Kinetics; Liver; Models, Chemical; Models, Molecular; Molecular Sequence Data; NAD; Piperidines; Protein Conformation; Structure-Activity Relationship	1997
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nature medicine, 1997, Volume: 3, Issue:10 Topics: Adenosine Triphosphate; Animals; Benzamides; Brain; Cells, Cultured; Cerebral Cortex; Cerebrovascular Circulation; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Hemodynamics; Immunity, Innate; Ischemic Attack, Transient; Isoquinolines; Mice; Mice, Knockout; N-Methylaspartate; NAD; Neurons; Neurotoxins; Nitrates; Nitric Oxide; Piperidines; Poly(ADP-ribose) Polymerases	1997
Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes. The Biochemical journal, 1997, Oct-01, Volume: 327 ( Pt 1) Topics: 2-Aminoadipic Acid; Bacterial Proteins; Cephamycins; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Kinetics; L-Lysine 6-Transaminase; Lysine; Molecular Weight; NAD; Oxidoreductases Acting on CH-NH Group Donors; Picolinic Acids; Pipecolic Acids; Piperidines; Pyrroles; Quaternary Ammonium Compounds; Streptomyces; Substrate Specificity; Transaminases	1997
Oxidative DNA damage by a metabolite of carcinogenic and reproductive toxic nitrobenzene in the presence of NADH and Cu(II). Biochemical and biophysical research communications, 1999, Apr-13, Volume: 257, Issue:2 Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Catalase; Cations; Cattle; Chelating Agents; Chromatography, High Pressure Liquid; Copper; Cytosine; Deoxyguanosine; DNA; DNA Damage; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Guanine; Humans; Hydrogen Peroxide; Metals; Models, Chemical; NAD; Nitrobenzenes; Nitroso Compounds; Oxidation-Reduction; Piperidines; Thymine	1999
BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase. Biochemical pharmacology, 2000, Apr-15, Volume: 59, Issue:8 Topics: Adenosine Diphosphate; ADP Ribose Transferases; Animals; Carrier Proteins; Cell Nucleus; Cytoplasm; DNA Damage; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; In Vitro Techniques; Lipid Peroxidation; Male; Molecular Chaperones; NAD; Oximes; Perfusion; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protective Agents; Proteins; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury	2000
Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system. Molecular pharmacology, 2001, Volume: 59, Issue:6 Topics: Aminobenzoates; Animals; DNA; DNA Damage; Electron Transport Complex IV; Energy Metabolism; Enzyme Inhibitors; Heart; In Vitro Techniques; Lipid Peroxidation; Male; Mitochondria; Myocardium; NAD; Oxidation-Reduction; Oximes; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Quinazolines; Quinazolinones; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury	2001
Double base lesions of DNA by a metabolite of carcinogenic benzo[a]pyrene. Biochemical and biophysical research communications, 2002, Jan-18, Volume: 290, Issue:2 Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Benzopyrenes; Binding Sites; Carcinogens; Cattle; Copper; Cyclin-Dependent Kinase Inhibitor p16; Deoxyguanosine; DNA; DNA Damage; DNA-Formamidopyrimidine Glycosylase; Free Radical Scavengers; Genes, p53; Genes, ras; Humans; N-Glycosyl Hydrolases; NAD; Oxidation-Reduction; Piperidines	2002
Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time. Nucleic acids research, 2003, Sep-01, Volume: 31, Issue:17 Topics: Animals; Benzamides; CHO Cells; Comet Assay; Cricetinae; DNA Damage; DNA Repair; DNA-Binding Proteins; DNA, Single-Stranded; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genotype; Isoquinolines; Methyl Methanesulfonate; Mutation; NAD; NADP; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Time Factors; X-ray Repair Cross Complementing Protein 1	2003
FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer research, 2003, Nov-01, Volume: 63, Issue:21 Topics: Acrylamides; Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Enzyme Inhibitors; Humans; K562 Cells; Kinetics; Liver Neoplasms; Mitochondria, Liver; NAD; Niacin; Niacinamide; Nicotinamide Phosphoribosyltransferase; Oxygen Consumption; Pentosyltransferases; Piperidines	2003
Effect of richlocaine alone or in combination with energostim on the severity of endotoxemia and survival of the skin under conditions of reduced blood flow. Bulletin of experimental biology and medicine, 2003, Volume: 136, Issue:3 Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Cell Survival; Cytochromes c; Drug Combinations; Endotoxemia; Erythrocytes; Histamine; Hydroxyproline; Hypoxia; Inflammation; Inosine; Keratinocytes; Lactates; Male; NAD; Necrosis; Piperidines; Rats; Regional Blood Flow; Serotonin; Skin; Surgical Flaps; Time Factors; Vasodilator Agents	2003
Metabolic signatures associated with a NAD synthesis inhibitor-induced tumor apoptosis identified by 1H-decoupled-31P magnetic resonance spectroscopy. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, May-01, Volume: 11, Issue:9 Topics: Acrylamides; Animals; Annexin A5; Apoptosis; Cell Cycle; Glycolysis; Guanine Nucleotides; Hydrogen-Ion Concentration; Intracellular Membranes; Magnetic Resonance Spectroscopy; Male; Mammary Neoplasms, Experimental; Membrane Potentials; Mice; Mice, Inbred C3H; Mitochondria; Mitosis; NAD; NADP; Neoplasm Transplantation; Nicotinamide Phosphoribosyltransferase; Pentosyltransferases; Phospholipids; Piperidines; Protein Binding; Time Factors	2005
Chemopotentiating effects of a novel NAD biosynthesis inhibitor, FK866, in combination with antineoplastic agents. European journal of medical research, 2006, Aug-30, Volume: 11, Issue:8 Topics: Acrylamides; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Cell Death; Cell Line, Tumor; Cell Survival; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Drug Combinations; Humans; K562 Cells; Leukemia, Myeloid, Acute; Melphalan; Methylnitronitrosoguanidine; Monocytes; NAD; Piperidines	2006
Characterization of NAD uptake in mammalian cells. The Journal of biological chemistry, 2008, Mar-07, Volume: 283, Issue:10 Topics: Acrylamides; Animals; Biological Transport; Cell Death; Dose-Response Relationship, Drug; HeLa Cells; Homeostasis; Humans; K562 Cells; Mice; NAD; NADP; NIH 3T3 Cells; Piperidines; Signal Transduction	2008
Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochemical and biophysical research communications, 2008, Mar-21, Volume: 367, Issue:4 Topics: Acrylamides; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cyanides; Dose-Response Relationship, Drug; Guanidines; Humans; Lung Neoplasms; NAD; Piperidines; Signal Transduction	2008
NAD depletion by FK866 induces autophagy. Autophagy, 2008, Volume: 4, Issue:3 Topics: Acrylamides; Antineoplastic Agents; Apoptosis Inducing Factor; Autophagy; Caspase 3; Cell Death; Cell Line, Tumor; Cell Membrane; Cytochromes c; Enzyme Activation; Humans; Lysosomes; Microtubule-Associated Proteins; NAD; Piperidines	2008
Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage. ChemMedChem, 2008, Volume: 3, Issue:5 Topics: Acrylamides; Antineoplastic Agents; Catalysis; Cell Line, Tumor; Cell Survival; Copper; Humans; NAD; Piperidines; Triazoles	2008
Weak coupling of ATP hydrolysis to the chemical equilibrium of human nicotinamide phosphoribosyltransferase. Biochemistry, 2008, Oct-21, Volume: 47, Issue:42 Topics: Acrylamides; Adenosine Triphosphate; Cytokines; Enzyme Inhibitors; Enzyme Stability; Humans; Hydrolysis; In Vitro Techniques; Kinetics; Models, Biological; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Phosphorylation; Piperidines; Recombinant Proteins; Thermodynamics	2008
The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies. Blood, 2009, Apr-02, Volume: 113, Issue:14 Topics: Acrylamides; Animals; Antineoplastic Agents; Cell Death; Cytokines; Dose-Response Relationship, Drug; Hematologic Neoplasms; HL-60 Cells; Humans; Jurkat Cells; K562 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Tumor Cells, Cultured; U937 Cells; Xenograft Model Antitumor Assays	2009
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science (New York, N.Y.), 2009, May-01, Volume: 324, Issue:5927 Topics: Acrylamides; Animals; ARNTL Transcription Factors; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Cell Line; Chromatin Assembly and Disassembly; Circadian Rhythm; CLOCK Proteins; Cytokines; Enzyme Inhibitors; Feedback, Physiological; Gene Expression Regulation; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Promoter Regions, Genetic; Sirtuin 1; Sirtuins; Trans-Activators; Transcription, Genetic	2009
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science (New York, N.Y.), 2009, May-01, Volume: 324, Issue:5927 Topics: Acrylamides; Adipose Tissue, White; Animals; ARNTL Transcription Factors; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Circadian Rhythm; CLOCK Proteins; Cytokines; Enzyme Inhibitors; Feedback, Physiological; Gene Expression Regulation; Hepatocytes; Humans; Liver; Mice; NAD; Nicotinamide Phosphoribosyltransferase; Nuclear Proteins; Period Circadian Proteins; Piperidines; Protein Binding; Sirtuin 1; Sirtuins; Trans-Activators; Transcription Factors; Transcription, Genetic	2009
Circadian rhythms. A circadian loop asSIRTs itself. Science (New York, N.Y.), 2009, May-01, Volume: 324, Issue:5927 Topics: Acetylation; Acrylamides; Animals; ARNTL Transcription Factors; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Circadian Rhythm; CLOCK Proteins; Cytokines; Feedback, Physiological; Gene Expression Regulation; Mice; Mutation; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Sirtuin 1; Sirtuins; Trans-Activators; Transcription Factors; Transcription, Genetic	2009
Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo. Biochemical pharmacology, 2009, May-15, Volume: 77, Issue:10 Topics: Acetophenones; Acrylamides; Animals; Cell Survival; Chromatography, High Pressure Liquid; Cytokines; Enzyme Inhibitors; Formates; HeLa Cells; Humans; Male; Mice; NAD; Niacinamide; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Organ Specificity; Piperidines; U937 Cells	2009
Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE. PloS one, 2009, Nov-19, Volume: 4, Issue:11 Topics: Acrylamides; Adenosine Triphosphate; Animals; Autophagy; Cell Proliferation; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Interferon-gamma; Jurkat Cells; Lymphocyte Activation; Membrane Potentials; Mice; Mice, Inbred C57BL; Myelin Sheath; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Poly(ADP-ribose) Polymerases; T-Lymphocytes; Tumor Necrosis Factor-alpha	2009
A preclinical study on the rescue of normal tissue by nicotinic acid in high-dose treatment with APO866, a specific nicotinamide phosphoribosyltransferase inhibitor. Molecular cancer therapeutics, 2010, Volume: 9, Issue:6 Topics: Acrylamides; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cell Death; Cell Line, Tumor; Cytoprotection; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Humans; Maximum Tolerated Dose; Mice; NAD; Niacin; Nicotinamide Phosphoribosyltransferase; Organ Specificity; Piperidines; RNA, Messenger; Substrate Specificity; Xenograft Model Antitumor Assays	2010
Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells. Experimental hematology, 2010, Volume: 38, Issue:11 Topics: Acrylamides; Adenosine Triphosphate; Aged; Apoptosis; Autophagy; Caspase 3; Cell Line, Tumor; Cells, Cultured; Cytokines; Drug Synergism; Female; Humans; Immunoblotting; Jurkat Cells; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Male; Membrane Potential, Mitochondrial; Middle Aged; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand; Tubulin	2010
Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool. The Journal of biological chemistry, 2010, Oct-29, Volume: 285, Issue:44 Topics: Acrylamides; Adenosine Triphosphate; Animals; Enzyme Inhibitors; Fibroblasts; HeLa Cells; Humans; Kynurenine; Male; Mice; Mitochondria; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Poly(ADP-ribose) Polymerases	2010
Overcoming temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repair. Cancer research, 2011, Mar-15, Volume: 71, Issue:6 Topics: Acrylamides; Adenosine Triphosphate; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Glycosylases; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Glioblastoma; Humans; Hydroxylamines; Immunoblotting; Methyl Methanesulfonate; NAD; Piperidines; Poly(ADP-ribose) Polymerases; RNA Interference; Temozolomide	2011
Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells. PloS one, 2011, Volume: 6, Issue:7 Topics: Acrylamides; Antigens, CD34; bcl-2-Associated X Protein; Cell Death; Cell Line, Tumor; Drug Screening Assays, Antitumor; Drug Synergism; Gene Silencing; Histone Deacetylase Inhibitors; Humans; Leukemia; NAD; Piperidines; Sirtuins; Up-Regulation	2011
Inhibition of nicotinamide phosphoribosyltransferase modifies LPS-induced inflammatory responses of human monocytes. Innate immunity, 2012, Volume: 18, Issue:3 Topics: Acrylamides; ADP-ribosyl Cyclase 1; Apoptosis; Cells, Cultured; Eicosanoids; Humans; Inflammation; Inflammation Mediators; Lipopolysaccharides; Monocytes; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Protein Processing, Post-Translational; Reactive Oxygen Species; Tumor Necrosis Factor-alpha; Up-Regulation	2012
Pre-B-cell colony-enhancing factor exerts a neuronal protection through its enzymatic activity and the reduction of mitochondrial dysfunction in in vitro ischemic models. Journal of neurochemistry, 2012, Volume: 120, Issue:2 Topics: Acrylamides; Animals; Brain; Cell Death; Cells, Cultured; DNA, Mitochondrial; Embryo, Mammalian; Female; Glucose; Glutamic Acid; Hypoxia; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; Mutation; NAD; Neurons; Neuroprotective Agents; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Pregnancy	2012
Anti-proliferation effect of APO866 on C6 glioblastoma cells by inhibiting nicotinamide phosphoribosyltransferase. European journal of pharmacology, 2012, Jan-15, Volume: 674, Issue:2-3 Topics: Acrylamides; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Intracellular Space; M Phase Cell Cycle Checkpoints; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Rats	2012
NAMPT pathway is involved in the FOXO3a-mediated regulation of GADD45A expression. Biochemical and biophysical research communications, 2012, Apr-20, Volume: 420, Issue:4 Topics: Acetylation; Acrylamides; Apoptosis; Cell Cycle Proteins; Cytokines; Forkhead Box Protein O3; Forkhead Transcription Factors; HEK293 Cells; Humans; NAD; Nicotinamide Phosphoribosyltransferase; Nuclear Proteins; Piperidines; RNA, Messenger; Sirtuin 1	2012
Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction. Antioxidants & redox signaling, 2013, Feb-20, Volume: 18, Issue:6 Topics: Acrylamides; Animals; Chemokine CXCL2; Humans; Male; Mice; Myocardial Infarction; Myocardial Reperfusion Injury; NAD; Neutrophil Infiltration; Nicotinamide Phosphoribosyltransferase; Oxidative Stress; Piperidines; Reactive Oxygen Species; Signal Transduction	2013
NAD+ levels control Ca2+ store replenishment and mitogen-induced increase of cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes. The Journal of biological chemistry, 2012, Jun-15, Volume: 287, Issue:25 Topics: Acrylamides; Calcium; Calcium Signaling; Cell Proliferation; Cyclic ADP-Ribose; Cytokines; Enzyme Inhibitors; Humans; Interleukin-2; Ion Channel Gating; Jurkat Cells; Mitogens; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; T-Lymphocytes; Thapsigargin; TRPM Cation Channels	2012
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase. The Journal of biological chemistry, 2012, Jul-06, Volume: 287, Issue:28 Topics: Acrylamides; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; AMP-Activated Protein Kinases; Animals; Blotting, Western; Carbazoles; Cell Line, Tumor; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; HEK293 Cells; Hep G2 Cells; Humans; Mice; Mice, Knockout; Models, Biological; Mutation; NAD; Niacinamide; Phosphorylation; Piperidines; Resveratrol; RNA Interference; Signal Transduction; Sirtuin 1; Stilbenes	2012
Estradiol acutely suppresses inhibition in the hippocampus through a sex-specific endocannabinoid and mGluR-dependent mechanism. Neuron, 2012, Jun-07, Volume: 74, Issue:5 Topics: Animals; Benzodioxoles; Benzoxazines; Biophysics; CA1 Region, Hippocampal; Cannabinoid Receptor Modulators; Castration; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Estradiol; Estrogens; Excitatory Amino Acid Agents; Female; GABA Antagonists; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Lactones; Male; Morpholines; NAD; Naphthalenes; Neural Inhibition; Neurons; Orlistat; Patch-Clamp Techniques; Phenols; Piperidines; Pyrazoles; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate	2012
Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells. International journal of cancer, 2013, Feb-15, Volume: 132, Issue:4 Topics: Acetylation; Acrylamides; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cytokines; Gene Knockout Techniques; Humans; Leukemia, Myeloid; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Sirtuins; Tumor Suppressor Protein p53; Up-Regulation	2013
Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition. Blood, 2012, Oct-25, Volume: 120, Issue:17 Topics: Acrylamides; Animals; Antineoplastic Agents; Autophagy; Cell Line, Tumor; Cell Survival; Cytokines; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Mechanistic Target of Rapamycin Complex 1; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Targeted Therapy; Multiple Myeloma; Multiprotein Complexes; NAD; Nicotinamide Phosphoribosyltransferase; Organ Specificity; Piperidines; Proteins; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays	2012
Nicotinamide phosphoribosyltransferase may be involved in age-related brain diseases. PloS one, 2012, Volume: 7, Issue:10 Topics: Acrylamides; Aging; Animals; Brain Diseases; Cerebellum; Corpus Striatum; Female; Hippocampus; Mice; NAD; Neurons; Nicotinamide Phosphoribosyltransferase; Piperidines; Rats	2012
Mitochondrial dysfunction causing cardiac sodium channel downregulation in cardiomyopathy. Journal of molecular and cellular cardiology, 2013, Volume: 54 Topics: Action Potentials; ADP-ribosyl Cyclase 1; Animals; Benzophenanthridines; Cardiomyopathies; Colforsin; Down-Regulation; Heart Conduction System; Humans; In Vitro Techniques; Membrane Glycoproteins; Membrane Potentials; Mice; Mice, Inbred C57BL; Mitochondria, Heart; Myocytes, Cardiac; NAD; NAV1.5 Voltage-Gated Sodium Channel; Organophosphorus Compounds; Oxidative Stress; Patch-Clamp Techniques; Piperidines; Reactive Oxygen Species	2013
Intracellular NAD(+) depletion induces autophagic death in multiple myeloma cells. Autophagy, 2013, Volume: 9, Issue:3 Topics: Acrylamides; Apoptosis; Autophagy; Cell Death; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Gene Transfer Techniques; Humans; Lentivirus; Multiple Myeloma; NAD; Piperidines; Transcription, Genetic	2013
Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications. The Journal of biological chemistry, 2013, Feb-01, Volume: 288, Issue:5 Topics: Acrylamides; Adenosine Triphosphate; Animals; Carbon Isotopes; Cell Death; Cell Line, Tumor; Citric Acid Cycle; Enzyme Inhibitors; Female; Glycolysis; Humans; Isotope Labeling; Mice; Mice, SCID; NAD; Neoplasms; Nicotinamide Phosphoribosyltransferase; Pentose Phosphate Pathway; Piperidines; Serine; Xenograft Model Antitumor Assays	2013
Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. The Journal of clinical investigation, 2013, Volume: 123, Issue:3 Topics: Acrylamides; Animals; Autophagy; Autophagy-Related Protein 5; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytokines; Disease Progression; Electron Transport Complex I; Female; Gene Knockdown Techniques; Humans; Lung Neoplasms; Mammary Neoplasms, Experimental; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred BALB C; Mice, SCID; Microtubule-Associated Proteins; Mitochondria; Multiprotein Complexes; NAD; Neoplasm Transplantation; Niacin; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Protein Transport; Proteins; Recombinant Proteins; Saccharomyces cerevisiae Proteins; TOR Serine-Threonine Kinases	2013
NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity. Experimental hematology, 2013, Volume: 41, Issue:6 Topics: Acrylamides; Animals; Bone and Bones; Cell Differentiation; Coculture Techniques; Cytokines; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Mice; Mice, SCID; Multiple Myeloma; NAD; Neoplasm Proteins; NF-kappa B; Niacinamide; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Osteoclasts; Osteolysis; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Rabbits; Sirtuin 1; Tumor Cells, Cultured; Up-Regulation	2013
Intracellular NAD⁺ depletion enhances bortezomib-induced anti-myeloma activity. Blood, 2013, Aug-15, Volume: 122, Issue:7 Topics: Acrylamides; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Biomarkers, Tumor; Blotting, Western; Boronic Acids; Bortezomib; Case-Control Studies; Caspases; Cell Proliferation; Drug Synergism; Female; Fluorescent Antibody Technique; Gene Expression Profiling; Humans; Male; Mice; Mice, SCID; Multiple Myeloma; NAD; Neoplasm Recurrence, Local; NF-kappa B; Nicotinamide Phosphoribosyltransferase; Oligonucleotide Array Sequence Analysis; Piperidines; Poly(ADP-ribose) Polymerases; Prognosis; Pyrazines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2013
CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells. The Journal of biological chemistry, 2013, Sep-06, Volume: 288, Issue:36 Topics: 5'-Nucleotidase; Acrylamides; ADP-ribosyl Cyclase 1; Cell Death; Cell Line, Tumor; Cytokines; Down-Regulation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Silencing; GPI-Linked Proteins; Humans; Membrane Glycoproteins; NAD; Neoplasm Proteins; Neoplasms; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Piperidines	2013
Bidirectional modulatory effect of 17β-estradiol on NMDA receptors via ERα and ERβ in the dentate gyrus of juvenile male rats. Neuropharmacology, 2013, Volume: 75 Topics: Animals; Dentate Gyrus; Dose-Response Relationship, Drug; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Excitatory Postsynaptic Potentials; Female; Ginsenosides; In Vitro Techniques; Male; NAD; Phenols; Piperazines; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sapogenins	2013
Targeting of NAD metabolism in pancreatic cancer cells: potential novel therapy for pancreatic tumors. Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Jan-01, Volume: 20, Issue:1 Topics: Acrylamides; ADP-ribosyl Cyclase 1; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytokines; Female; Humans; Membrane Glycoproteins; Mice; Mice, Nude; Molecular Targeted Therapy; NAD; Nicotinamide Phosphoribosyltransferase; Pancreatic Neoplasms; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Sirtuin 1; Tumor Burden; Xenograft Model Antitumor Assays	2014
Targeting metabolic scavenging in pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Jan-01, Volume: 20, Issue:1 Topics: Acrylamides; Animals; Antineoplastic Agents; Female; Humans; NAD; Pancreatic Neoplasms; Piperidines	2014
Hepatectomy-related hypophosphatemia: a novel phosphaturic factor in the liver-kidney axis. Journal of the American Society of Nephrology : JASN, 2014, Volume: 25, Issue:4 Topics: Acrylamides; Animals; Hepatectomy; Hypophosphatemia; Kidney; Male; Mice; Mice, Inbred C57BL; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Parathyroidectomy; Piperidines; Rats; Rats, Wistar; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type IIa	2014
Nicotinamide phosphoribosyltransferase (NAMPT) activity is essential for survival of resting lymphocytes. Immunology and cell biology, 2014, Volume: 92, Issue:2 Topics: Acrylamides; Animals; Apoptosis; Cell Survival; Cytokines; Humans; Male; Mice; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases	2014
The anti-lymphoma activity of APO866, an inhibitor of nicotinamide adenine dinucleotide biosynthesis, is potentialized when used in combination with anti-CD20 antibody. Leukemia & lymphoma, 2014, Volume: 55, Issue:9 Topics: Acrylamides; Animals; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Apoptosis; Biosynthetic Pathways; Caspase 3; Cell Line, Tumor; Disease Models, Animal; Drug Synergism; Humans; Lymphoma; Membrane Potential, Mitochondrial; Mice; Mice, SCID; NAD; Piperidines; Reactive Oxygen Species; Rituximab; Xenograft Model Antitumor Assays	2014
Endogenous NAMPT dampens chemokine expression and apoptotic responses in stressed tubular cells. Biochimica et biophysica acta, 2014, Volume: 1842, Issue:2 Topics: Acrylamides; Animals; Apoptosis; Blotting, Western; Cell Line; Chemokine CCL2; Chemokine CCL5; Chemokines; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Epithelial Cells; Gene Expression; Humans; Immunohistochemistry; Interleukin-6; Kidney; Kidney Tubules, Proximal; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Rats; Rats, Inbred WKY; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tumor Necrosis Factor-alpha	2014
NAD⁺ depletion by APO866 in combination with radiation in a prostate cancer model, results from an in vitro and in vivo study. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2014, Volume: 110, Issue:2 Topics: Acrylamides; Animals; Cell Growth Processes; Cell Line, Tumor; Cell Survival; Chemoradiotherapy; Female; Humans; Male; Mice; Mice, Inbred BALB C; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Prostatic Neoplasms; Radiation-Sensitizing Agents; Xenograft Model Antitumor Assays	2014
A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis. Autophagy, 2014, Volume: 10, Issue:4 Topics: Acrylamides; Apoptosis; Autophagy; Caspase 3; Cell Line, Tumor; Humans; Leukemia; Lymphoma; NAD; Piperidines; Reactive Oxygen Species	2014
Nicotinamide phosphoribosyltransferase inhibitor is a novel therapeutic candidate in murine models of inflammatory lung injury. American journal of respiratory cell and molecular biology, 2014, Volume: 51, Issue:2 Topics: Acrylamides; Animals; Anti-Inflammatory Agents; Apoptosis; Bronchoalveolar Lavage Fluid; Caspase 3; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Inflammation Mediators; Lung; Mice; Mice, Inbred C57BL; NAD; Neutrophils; Nicotinamide Phosphoribosyltransferase; Piperidines; Pneumonia; Respiratory Distress Syndrome; Ventilator-Induced Lung Injury	2014
Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels. DNA repair, 2014, Volume: 23 Topics: Acetylation; Acrylamides; Enzyme Inhibitors; HEK293 Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lysine; NAD; Phenanthrenes; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Sirtuin 2; Tubulin	2014
NAMPT-mediated salvage synthesis of NAD+ controls morphofunctional changes of macrophages. PloS one, 2014, Volume: 9, Issue:5 Topics: Acrylamides; Actin Cytoskeleton; Adenosine Triphosphate; Blotting, Western; Cell Line; Cytokines; DNA Primers; Fluorescence; Humans; Macrophages; Microscopy, Electron, Scanning; NAD; Nicotinamide Phosphoribosyltransferase; Oxidation-Reduction; Oxygen Consumption; Phagocytosis; Piperidines; Transfection	2014
Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis. Proceedings of the National Academy of Sciences of the United States of America, 2014, Jul-15, Volume: 111, Issue:28 Topics: Acrylamides; Animals; Cells, Cultured; Cerebral Cortex; Enzyme Activation; Glucose; Glucose-6-Phosphate; Glycolysis; Hexokinase; Methylnitronitrosoguanidine; Mice; Mitochondria; NAD; Nerve Tissue Proteins; Neurons; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases	2014
Up-regulation of nicotinamide phosphoribosyltransferase and increase of NAD+ levels by glucose restriction extend replicative lifespan of human fibroblast Hs68 cells. Biogerontology, 2015, Volume: 16, Issue:1 Topics: Acrylamides; Benzamides; Cell Line; Cell Proliferation; Cell Survival; Cells, Cultured; Cellular Senescence; Cytokines; Dose-Response Relationship, Drug; Fibroblasts; Glucose; Humans; NAD; Naphthols; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Sirtuin 1; Up-Regulation	2015
Pre-B cell colony enhancing factor induces Nampt-dependent translocation of the insulin receptor out of lipid microdomains in A549 lung epithelial cells. American journal of physiology. Endocrinology and metabolism, 2015, Feb-15, Volume: 308, Issue:4 Topics: Acrylamides; Antigens, CD; Caveolin 1; Cell Line; Cytokines; Enzyme Inhibitors; Humans; Insulin; Insulin Resistance; Lung; Membrane Microdomains; NAD; Nicotinamide Phosphoribosyltransferase; Phosphorylation; Piperidines; Protein Processing, Post-Translational; Protein Transport; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Recombinant Proteins; Respiratory Mucosa; Signal Transduction	2015
NAMPT inhibitor and metabolite protect mouse brain from cryoinjury through distinct mechanisms. Neuroscience, 2015, Apr-16, Volume: 291 Topics: Acrylamides; Acute Disease; Animals; Astrocytes; Brain; Brain Injuries; Calcium-Binding Proteins; Cell Count; Chronic Disease; Cold Temperature; Cytokines; Disease Models, Animal; Macrophages; Male; Mice, Inbred BALB C; Microfilament Proteins; Microglia; NAD; Neurons; Neuroprotective Agents; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Piperidines	2015
Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells. PloS one, 2015, Volume: 10, Issue:4 Topics: 3T3 Cells; Acrylamides; Adenosine Triphosphate; Animals; Catalysis; Energy Metabolism; Glucose; HEK293 Cells; Humans; Insulinoma; Mice; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Rats; Tankyrases; Ubiquitin	2015
Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, Leads to Altered Carbohydrate Metabolism in Cancer Cells. The Journal of biological chemistry, 2015, Jun-19, Volume: 290, Issue:25 Topics: Acrylamides; Carbohydrate Metabolism; Cytokines; Enzyme Inhibitors; Humans; Mass Spectrometry; NAD; Neoplasm Proteins; Neoplasms; Nicotinamide Phosphoribosyltransferase; Piperidines; Sugar Phosphates	2015
APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells. Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Sep-01, Volume: 21, Issue:17 Topics: Acrylamides; Adenosine Triphosphate; Aged; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cell Survival; Chromosome Aberrations; Cyclosporine; Drug Resistance, Neoplasm; Drug Synergism; Endoplasmic Reticulum Stress; Female; Gene Expression; Humans; Immunoglobulin Heavy Chains; Leukemia; Male; Membrane Potential, Mitochondrial; Middle Aged; Mitochondria; Mutation; NAD; Neoplasm Staging; Niacin; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Primary Cell Culture; Prognosis; Tumor Cells, Cultured; Unfolded Protein Response	2015
FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes. Biochemical pharmacology, 2015, Nov-01, Volume: 98, Issue:1 Topics: Acrylamides; Animals; Cells, Cultured; Cytokines; Gene Expression Regulation; Hydrogen Peroxide; Insulin; Mitochondria; Myocytes, Cardiac; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Norepinephrine; Piperidines; Rats; Stress, Physiological	2015
A Nampt inhibitor FK866 mimics vitamin B3 deficiency by causing senescence of human fibroblastic Hs68 cells via attenuation of NAD(+)-SIRT1 signaling. Biogerontology, 2015, Volume: 16, Issue:6 Topics: Acrylamides; AMP-Activated Protein Kinases; Cell Line; Cell Proliferation; Cellular Senescence; Cytokines; Enzyme Inhibitors; Fibroblasts; Glutathione; Humans; NAD; NADP; Niacin; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Signal Transduction; Sirtuin 1; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53	2015
EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition. BMC cancer, 2015, Nov-05, Volume: 15 Topics: Acrylamides; Adenosine Triphosphate; AMP-Activated Protein Kinases; Apoptosis; Caspases; Cell Line, Tumor; Cell Survival; Cytokines; Drug Resistance, Neoplasm; Eukaryotic Initiation Factor-2; Eukaryotic Initiation Factor-4E; Humans; Jurkat Cells; Leukemia; NAD; Nicotinamide Phosphoribosyltransferase; Phosphorylation; Piperidines; Protein Biosynthesis; Signal Transduction; Stress, Physiological; TOR Serine-Threonine Kinases; Transcription, Genetic	2015
NAMPT suppresses glucose deprivation-induced oxidative stress by increasing NADPH levels in breast cancer. Oncogene, 2016, 07-07, Volume: 35, Issue:27 Topics: Acrylamides; Animals; Blotting, Western; Breast Neoplasms; Cell Hypoxia; Cell Line; Cell Line, Tumor; Cytokines; Female; Glucose; HCT116 Cells; Humans; Mice, Inbred BALB C; Mice, Nude; NAD; NADP; Nicotinamide Phosphoribosyltransferase; Oxidative Stress; Piperidines; Reactive Oxygen Species; RNA Interference; Xenograft Model Antitumor Assays	2016
IDO Downregulation Induces Sensitivity to Pemetrexed, Gemcitabine, FK866, and Methoxyamine in Human Cancer Cells. PloS one, 2015, Volume: 10, Issue:11 Topics: Acrylamides; Animals; BRCA2 Protein; Cell Line, Tumor; Clone Cells; Deoxycytidine; DNA Repair; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Induction; Floxuridine; Gemcitabine; Gene Knockdown Techniques; Humans; Hydroxylamines; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice, SCID; NAD; Pemetrexed; Piperidines; RNA, Small Interfering; Thymidylate Synthase; Xenograft Model Antitumor Assays	2015
Nicotinamide phosphoribosyltransferase inhibitor APO866 induces C6 glioblastoma cell death via autophagy. Die Pharmazie, 2015, Volume: 70, Issue:10 Topics: Acrylamides; Animals; Autophagy; Cell Death; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Glioblastoma; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Rats; Vacuoles	2015
Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model. Oncotarget, 2016, Jan-19, Volume: 7, Issue:3 Topics: 5'-Nucleotidase; Acrylamides; Adenosine Triphosphate; Animals; Cell Line, Tumor; Cytokines; Female; GPI-Linked Proteins; Humans; Mice; Mice, Nude; NAD; Niacinamide; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Ovarian Neoplasms; Piperidines; Pyridinium Compounds; RNA Interference; RNA, Small Interfering	2016
Regulation of the Nampt-mediated NAD salvage pathway and its therapeutic implications in pancreatic cancer. Cancer letters, 2016, 08-28, Volume: 379, Issue:1 Topics: 3' Untranslated Regions; Acrylamides; Animals; Antimetabolites, Antineoplastic; Binding Sites; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cytokines; Deoxycytidine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Gemcitabine; Glycolysis; Humans; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; MicroRNAs; NAD; Nicotinamide Phosphoribosyltransferase; Pancreatic Neoplasms; Piperidines; RNA Interference; Time Factors; Transfection; Tumor Burden; Xenograft Model Antitumor Assays	2016
Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation. Cell death and differentiation, 2017, Volume: 24, Issue:1 Topics: Adenosine Triphosphate; Cells, Cultured; Electron Transport Complex I; F-Box Proteins; Humans; Iodoacetic Acid; Isoquinolines; Membrane Potential, Mitochondrial; Mitochondria; Mitophagy; NAD; Oxygen Consumption; Parkinson Disease; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Polymorphism, Single Nucleotide; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Sodium Cyanide	2017
EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells. Oncotarget, 2017, Apr-11, Volume: 8, Issue:15 Topics: Acrylamides; Bone Neoplasms; Cell Line, Tumor; Cytokines; Drug Resistance, Neoplasm; Enzyme Inhibitors; HeLa Cells; Humans; NAD; Nicotinamide Phosphoribosyltransferase; Oncogene Proteins, Fusion; Piperidines; Proto-Oncogene Protein c-fli-1; RNA-Binding Protein EWS; Sarcoma, Ewing	2017
Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway. Lipids in health and disease, 2017, Apr-27, Volume: 16, Issue:1 Topics: Acrylamides; AMP-Activated Protein Kinases; Animals; Carbazoles; Cell Line; Cytokines; Diet, High-Fat; Enzyme Inhibitors; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Liver; Male; Mice; Mice, Inbred C57BL; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Non-alcoholic Fatty Liver Disease; Oleic Acid; Piperidines; Resveratrol; Signal Transduction; Sirtuin 1; Sterol Regulatory Element Binding Protein 1; Stilbenes	2017
The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in Cancer research, 2017, 08-01, Volume: 77, Issue:15 Topics: Acrylamides; Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Dacarbazine; Enzyme Inhibitors; Female; Glioma; Humans; Isocitrate Dehydrogenase; Mice; Mice, SCID; Mutation; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Random Allocation; Stress, Physiological; Temozolomide; Xenograft Model Antitumor Assays	2017
Inhibition of NAMPT decreases cell growth and enhances susceptibility to oxidative stress. Oncology reports, 2017, Volume: 38, Issue:3 Topics: A549 Cells; Acrylamides; Antioxidants; Catalase; Cell Line; Cell Line, Tumor; Cell Proliferation; Cytokines; DNA Repair; Down-Regulation; Glutaredoxins; HEK293 Cells; Humans; NAD; Nicotinamide Phosphoribosyltransferase; Oxidative Stress; Piperidines; Poly (ADP-Ribose) Polymerase-1; Proliferating Cell Nuclear Antigen; Ribosomal Proteins	2017
Extracellular NAMPT/visfatin causes p53 deacetylation via NAD production and SIRT1 activation in breast cancer cells. Cell biochemistry and function, 2017, Volume: 35, Issue:6 Topics: Acrylamides; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Humans; MCF-7 Cells; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Recombinant Proteins; Sirtuin 1; Tumor Suppressor Protein p53; Up-Regulation	2017
NAD metabolism fuels human and mouse intestinal inflammation. Gut, 2018, Volume: 67, Issue:10 Topics: Acrylamides; Animals; Cell Differentiation; Colitis, Ulcerative; Colonic Neoplasms; Dexamethasone; Energy Metabolism; Gastrointestinal Agents; Humans; Infliximab; Intestinal Mucosa; Macrophages; Mice; Monocytes; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines	2018
Oleate ameliorates palmitate-induced reduction of NAMPT activity and NAD levels in primary human hepatocytes and hepatocarcinoma cells. Lipids in health and disease, 2017, Oct-03, Volume: 16, Issue:1 Topics: Acrylamides; Apoptosis; Cell Survival; Cytokines; Enzyme Inhibitors; Gene Expression; Hep G2 Cells; Hepatocytes; Humans; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Oleic Acid; Palmitic Acid; Piperidines; Primary Cell Culture; RNA, Messenger	2017
Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy. Circulation, 2018, 05-22, Volume: 137, Issue:21 Topics: Acrylamides; AMP-Activated Protein Kinases; Animals; Cardiomyopathy, Dilated; Citric Acid; Cytokines; Dietary Supplements; Disease Models, Animal; Gene Expression Profiling; Heart Failure; Metabolome; Mice; Mice, Transgenic; Myocytes, Cardiac; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Phosphotransferases (Alcohol Group Acceptor); Piperidines; PPAR alpha; Pyridinium Compounds; Rats; Serum Response Factor	2018
ROS-Mediated 15-Hydroxyprostaglandin Dehydrogenase Degradation via Cysteine Oxidation Promotes NAD Cell chemical biology, 2018, 03-15, Volume: 25, Issue:3 Topics: Acrylamides; ADP-ribosyl Cyclase 1; Autophagy; Cell Line, Tumor; Cell Movement; Cysteine; Dinoprostone; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Hydroxyprostaglandin Dehydrogenases; Membrane Glycoproteins; Mutagenesis, Site-Directed; NAD; Niacin; Oxidation-Reduction; Piperidines; Proteasome Endopeptidase Complex; Protein Stability; Reactive Oxygen Species; Sulfonic Acids	2018
Loss of NAMPT in aging retinal pigment epithelium reduces NAD Aging, 2018, Jun-12, Volume: 10, Issue:6 Topics: Acrylamides; Aging; Animals; Cells, Cultured; Cytokines; Epithelial Cells; Gene Expression Regulation; Humans; Male; Mice; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Piperidines; Retinal Pigment Epithelium; Reverse Transcriptase Polymerase Chain Reaction	2018
Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition. Molecular & cellular proteomics : MCP, 2018, Volume: 17, Issue:10 Topics: Acrylamides; ADP-ribosyl Cyclase 1; Animals; Cell Line; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; Humans; Integrins; Mice, Nude; NAD; Oxidative Stress; Piperidines; Proteome; Proteomics; Reactive Oxygen Species; Signal Transduction; STAT3 Transcription Factor	2018
CD38 Inhibits Prostate Cancer Metabolism and Proliferation by Reducing Cellular NAD Molecular cancer research : MCR, 2018, Volume: 16, Issue:11 Topics: Acrylamides; ADP-ribosyl Cyclase 1; AMP-Activated Protein Kinase Kinases; Cell Line, Tumor; Cell Proliferation; Cellular Reprogramming; Cytokines; Fatty Acids; Gene Expression; Humans; Lipids; Male; Membrane Glycoproteins; Mitochondria; NAD; Nicotinamide Phosphoribosyltransferase; PC-3 Cells; Piperidines; Prostatic Neoplasms; Protein Kinases; Transcriptome; Transfection; Tretinoin	2018
Pharmacological bypass of NAD Proceedings of the National Academy of Sciences of the United States of America, 2018, 10-16, Volume: 115, Issue:42 Topics: Acrylamides; Animals; Antineoplastic Agents, Phytogenic; Drug Combinations; Francisella tularensis; Ganglia, Spinal; NAD; Nerve Degeneration; Neurons; Niacinamide; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Piperidines; Pyridinium Compounds; Vincristine	2018
Nicotinamide Metabolism Modulates the Proliferation/Differentiation Balance and Senescence of Human Primary Keratinocytes. The Journal of investigative dermatology, 2019, Volume: 139, Issue:8 Topics: 3T3 Cells; Acrylamides; Adult; Animals; Cell Differentiation; Cell Proliferation; Cellular Senescence; Cytokines; Female; Healthy Volunteers; Humans; Keratinocytes; Mice; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Primary Cell Culture; Skin; Skin Aging; Stem Cells	2019
Inflammatory macrophage dependence on NAD Nature immunology, 2019, Volume: 20, Issue:4 Topics: Acrylamides; Animals; Cells, Cultured; Cytokines; DNA Damage; Electron Transport Complex III; HEK293 Cells; Humans; Inflammation; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Mitochondria; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Reactive Oxygen Species	2019
Nuclear transport of nicotinamide phosphoribosyltransferase is cell cycle-dependent in mammalian cells, and its inhibition slows cell growth. The Journal of biological chemistry, 2019, 05-31, Volume: 294, Issue:22 Topics: 3T3-L1 Cells; Acrylamides; Active Transport, Cell Nucleus; Animals; Cell Cycle Checkpoints; Cell Nucleus; Cell Proliferation; Cell Survival; Cytoplasm; Hep G2 Cells; Histones; Humans; Mice; Mutagenesis, Site-Directed; NAD; Nicotinamide Phosphoribosyltransferase; Oxidative Stress; Piperidines; Poly(ADP-ribose) Polymerases; Recombinant Fusion Proteins; Sirtuins	2019
Nicotinamide phosphoribosyltransferase‑related signaling pathway in early Alzheimer's disease mouse models. Molecular medicine reports, 2019, Volume: 20, Issue:6 Topics: Acrylamides; Alzheimer Disease; Amyloid; Animals; Behavior, Animal; Cytokines; Disease Models, Animal; Hippocampus; Learning; Male; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Signal Transduction; Sirtuin 1	2019
Divergent metabolic responses dictate vulnerability to NAMPT inhibition in ovarian cancer. FEBS letters, 2020, Volume: 594, Issue:9 Topics: Acrylamides; Cell Line, Tumor; Cytokines; Female; Glycolysis; Humans; Lactic Acid; NAD; Niacin; Nicotinamide Phosphoribosyltransferase; Ovarian Neoplasms; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors	2020
Targeting NAD Trends in cancer, 2020, Volume: 6, Issue:1 Topics: Acrylamides; Adenosine; Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase 1; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cytokines; Drug Synergism; Humans; Membrane Glycoproteins; Multiple Myeloma; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Regulatory; Tumor Escape; Warburg Effect, Oncologic	2020
Targeting NAD immunometabolism limits severe graft-versus-host disease and has potent antileukemic activity. Leukemia, 2020, Volume: 34, Issue:7 Topics: Acrylamides; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Cytokines; Energy Metabolism; Female; Graft vs Host Disease; Humans; Immunologic Memory; Leukemia; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; T-Lymphocytes, Regulatory; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2020
Targeting the NAD Cell communication and signaling : CCS, 2020, 01-31, Volume: 18, Issue:1 Topics: Acrylamides; Adenomatous Polyposis Coli Protein; Animals; Axin Protein; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Cytokines; Female; Gene Knockdown Techniques; Humans; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Mutation; NAD; Neoplasm Invasiveness; Nicotinamide Phosphoribosyltransferase; Piperidines; Prognosis; Wnt Signaling Pathway	2020
Alkyladenine DNA glycosylase deficiency uncouples alkylation-induced strand break generation from PARP-1 activation and glycolysis inhibition. Scientific reports, 2020, 02-10, Volume: 10, Issue:1 Topics: Acrylamides; Alkylation; Animals; Cells, Cultured; Cytokines; DNA Breaks; DNA Glycosylases; DNA Repair; Fibroblasts; Glycolysis; Methyl Methanesulfonate; Mice; Mice, Knockout; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Poly (ADP-Ribose) Polymerase-1; Primary Cell Culture	2020
Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo. Nucleic acids research, 2020, 09-25, Volume: 48, Issue:17 Topics: Binding Sites; Catalytic Domain; Cell Line, Tumor; DNA Damage; DNA Repair; Fluorescence Resonance Energy Transfer; Green Fluorescent Proteins; Humans; Indazoles; Kinetics; Molecular Imaging; NAD; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Recombinant Proteins; X-ray Repair Cross Complementing Protein 1	2020
Local Targeting of NAD Cancer research, 2020, 11-15, Volume: 80, Issue:22 Topics: Acrylamides; Animals; Autophagy; B7-H1 Antigen; Brain Neoplasms; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Movement; Cyanides; Cytokines; Delayed-Action Preparations; Drug Carriers; Glioblastoma; Guanidines; Humans; Injections, Intralesional; Macrophages; Membrane Proteins; Mice; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Polymers; RNA, Messenger; Signal Transduction; Tumor Microenvironment; Up-Regulation	2020
Targeting the NAD Salvage Synthesis Pathway as a Novel Therapeutic Strategy for Osteosarcomas with Low NAPRT Expression. International journal of molecular sciences, 2021, Jun-10, Volume: 22, Issue:12 Topics: Acrylamides; Apoptosis; Bone Neoplasms; Cell Proliferation; Gene Expression Regulation, Enzymologic; Glioma; Humans; NAD; Osteosarcoma; Pentosyltransferases; Piperidines; Tumor Cells, Cultured	2021
FK866 inhibits colorectal cancer metastasis by reducing NAD Genes & genomics, 2022, Volume: 44, Issue:12 Topics: Acrylamides; Cancer-Associated Fibroblasts; Colorectal Neoplasms; Humans; NAD; Piperidines; Tumor Microenvironment	2022