nad has been researched along with niacinamide in 1274 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 671 (52.67) | 18.7374 |
| 1990's | 96 (7.54) | 18.2507 |
| 2000's | 157 (12.32) | 29.6817 |
| 2010's | 178 (13.97) | 24.3611 |
| 2020's | 172 (13.50) | 2.80 |
| Authors | Studies |
|---|---|
| Claycomb, WC | 2 |
| Bryson, TA; Dunlap, RB; Ellis, PD; Fisher, RR; Riddle, RM; Williams, TJ | 1 |
| Badawy, AA; Evans, M | 1 |
| Fukishima, M; Hayaishi, O; Okayama, H; Takahashi, Y | 1 |
| Barker, KL; O'Dorisio, MS | 1 |
| Baker, H; Frank, O; Sorrell, MF | 1 |
| Brady, RO; Brewer, HB; Fishman, PH; Moss, J; Osborne, JC; Vaughan, M | 1 |
| Safonova, TIa; Shelkovskiĭ, VI | 1 |
| Cobb, JR; Gholson, RK; Pearcy, SC | 1 |
| Klinger, W; Muller, D | 1 |
| Obersteiner, EJ; Sharma, RP | 1 |
| Burke, PJ; Schacter, LP | 1 |
| Reisbig, RR; Woody, RW | 1 |
| Gross, CJ; Henderson, LM | 2 |
| Jacobson, EL; Jacobson, MK; Lange, RA | 1 |
| Hockin, LJ; Legg, RF; Paine, AJ | 1 |
| Chen, JL; Tritz, GJ | 1 |
| Collier, RJ | 1 |
| Schoental, R | 2 |
| Miller, EG | 1 |
| Bernofsky, C; Chang, SC | 1 |
| Doi, K | 1 |
| Caplan, AI; Rosenberg, MJ | 1 |
| Hill, KR; Rechsteiner, M | 1 |
| Elliott, G; Rechsteiner, M | 1 |
| Mailhammer, R; Rohrer, H; Zillig, W | 1 |
| Calva, E; Marsh, M; Nunez, R | 1 |
| Bitensky, MW; Cooper, C; Hertzberg, L; Mehta, H; Miki, N; Solomon, RA; Wheeler, MA | 1 |
| Graham, MN; Overman, DO; Roy, WA | 1 |
| Beaudoin, AR | 1 |
| Kunitake, T; Shinkai, S; Tamaki, K | 1 |
| Bryson, TA; Donelson, DM; Dunlap, RB; Ellis, PD; Fisher, RR | 1 |
| Baue, AE; Chaudry, IH; Sayeed, MM; Zweig, S | 1 |
| Barz, W; Heeger, V; Leienbach, KW | 2 |
| Briones, E; Calva, E; López-Soriano, F; Marsch, M; Núñez, R | 1 |
| Bennett, LL; Nelson, JA; Rose, LM | 1 |
| Davies, MI; Halldórsson, H; Shall, S; Skidmore, CJ | 1 |
| Kidwell, WR; Lorimer, WS; Stone, PR | 1 |
| Jacobson, MK; Lange, RA | 1 |
| Hajdu, J; Sigman, DS | 1 |
| Chung, DW; Collier, RJ | 1 |
| Bono, VH; Fernandez-Pol, JA; Johnson, GS | 1 |
| Glynn, D; Rossini, A; Wick, MM | 1 |
| Davies, MI; Shall, S; Skidmore, CJ | 1 |
| Grässle, B; Jaus, H; Romen, W; Siebert, G; Sturm, G | 1 |
| Grier, DL; Van Eikeren, P | 1 |
| Streffer, C | 3 |
| Kawamura, M; Kitamura, A; Shimoyama, M; Tanigawa, Y | 1 |
| Pshetakovskiĭ, IL | 1 |
| Moss, J; Vaughan, M | 1 |
| Matinian, KS; Umanskiĭ, SR | 1 |
| Besedin, SN | 1 |
| Davies, MI; Goodwin, PM; Lewis, PJ; Shall, S; Skidmore, CJ | 1 |
| Foster, JW; Kinney, DM; Moat, AG | 2 |
| Fain, JN; Moreno, FJ; Shepherd, RE | 1 |
| Barton, RA; Chaffin, WL; Jacobson, EL; Jacobson, MK | 1 |
| Lin, MC; Moss, J; Stanley, SJ | 1 |
| Osman, MS; Rickwood, D | 1 |
| Willmitzer, L | 1 |
| Fujiki, H; Marks, PA; Sugimura, T; Terada, M | 1 |
| Blankenhorn, G | 1 |
| Butterworth, PJ; Ramasamy, I | 2 |
| Konno, K; Watanabe, M | 1 |
| Brightwell, MD; Leech, CE; O'Farrell, MK; Shall, S; Whish, WJ | 1 |
| Giles, KH; Macmillan, KL | 1 |
| Ariji, F; Konno, K; Takusagawa, K; Watanabe, M | 1 |
| Ammon, HP | 1 |
| Boyd, RS; Donnelly, LE; MacDermot, J | 1 |
| Filov, VA; Reztsova, VV; Stukov, AN | 1 |
| Caldini, R; Chevanne, M; Magnelli, L | 1 |
| Aneiro, L; Aune, T; Korn, JH; Nuveen, E; Piela-Smith, TH | 1 |
| Friedlos, F; Knox, RJ | 1 |
| Aranda, A; Sánchez-Pacheco, A | 1 |
| Dawson, JS; Mitcheltree, LW; Yourick, JJ | 1 |
| Abrahamson, JA; Biggs, PJ; Friedlos, F; Knox, RJ | 1 |
| Agnesini, C; Barbieri, D; Capri, M; Cristofalo, EA; Grassilli, E; Monti, D; Ronchetti, I; Salvioli, S; Troiano, L; Tropea, F | 1 |
| Banasik, M; Komura, H; Shimoyama, M; Ueda, K | 1 |
| Hardy, DL; Mowbray, J | 2 |
| Drevenstedt, B; Hoshino, J; Kröger, H; Schalge, S | 1 |
| Mitaka, T; Pitot, HC; Sargent, LM; Sattler, CA; Sattler, GL | 1 |
| de Vries, R; Kluivers, AW; Mol, ME | 1 |
| Blomquist, CH; Hakanson, EY | 1 |
| Aarhus, R; Lee, HC | 2 |
| Law, PY; Loh, HH; Roerig, SC | 1 |
| Kass, GE; Meier, P; Richter, C; Schlegel, J | 1 |
| Clark, CR; Mitcheltree, LW; Yourick, JJ | 1 |
| Capparelli, AW; Jo, OD; Suzuki, M; Yanagawa, N | 1 |
| Meier, P; Richter, C | 1 |
| Cynamon, MH; Godek, CP | 1 |
| Niven, DF; O'Reilly, T | 3 |
| Micheli, V; Ricci, C; Sestini, S; Simmonds, HA | 1 |
| Chan, P; Gross, CL; Meier, HL; Smith, WJ | 1 |
| Eisenthal, R; Kasraien, M; Whish, WJ | 1 |
| Micheli, V; Ricci, C; Simmonds, HA | 1 |
| Andreoli, SP | 1 |
| Ichihara, A; Inoue, C; Nakamura, T; Okamoto, H; Yamamoto, H | 1 |
| Lane, DA; Nadeau, D | 2 |
| Kluivers, AW; Mol, MA; van de Ruit, AM | 1 |
| Ribeiro-Neto, FA; Rodbell, M | 1 |
| Hilz, H; Janssen, OE | 1 |
| Donchenko, GV; Muliavko, NA; Petik, AV | 1 |
| Anderson, VE; LaReau, RD; Wan, W | 1 |
| Montecucco, C; Papini, E; Rappuoli, R; Sandoná, D; Schiavo, G | 1 |
| Bender, DA | 1 |
| Abraham, MI; al-Mahrouq, HA; Campbell, PI; Kempson, SA | 1 |
| Bukhmet, MI; Moroz, AR; Nefedov, LI; Ostrovskiĭ, IuM | 1 |
| Henning, SM; McKee, RW; Swendseid, ME | 1 |
| Ganeshaguru, K; Hoffbrand, AV; Latini, L; Piga, A | 1 |
| Atlef, N; Doll, N; Hermitte, L; Payan, MJ; Scheimann, A; Vague, P; Vialettes, B | 1 |
| Benjamin, RC; Jacobson, EL; Jacobson, MK; Moss, J; Rankin, PW | 1 |
| Robins, RK; Saunders, PP; Spindler, CD; Tan, MT | 1 |
| Micheli, V; Simmonds, HA | 1 |
| Belovskaya, LN; Denisenko, MF; Filippovich, IV; Soldatenkov, VA | 1 |
| Carrera, CJ; Carson, DA; Kubota, M; Seto, S; Wasson, DB | 1 |
| Bacon, RA; Kempson, SA; McAteer, JA; Wu, KI | 1 |
| Grahn, H; Grätz, R; Kröger, H | 4 |
| Brandwein, HJ; Epstein, SA; Giannella, RA | 1 |
| Carrera, CJ; Carson, DA; Seto, S; Wasson, DB | 2 |
| Simpson, LL; Stiles, BG; Wilkins, TD; Zepeda, HH | 1 |
| Coote, JM; Johnstone, AP; Lau, KM; Williams, GT | 1 |
| Gowans, B; Henderson, JF; Hunting, D | 1 |
| Bauer, PI; Hakam, A; Kun, E | 1 |
| Durand, P; Langrené, S; Le Goffic, F; Sicsic, S | 1 |
| Cochrane, CG; Hinshaw, DB; Hyslop, PA; Schraufstatter, IU; Spragg, RG | 1 |
| Andersson, A; Sandler, S | 1 |
| Cochrane, CG; Hinshaw, DB; Hyslop, PA; Schraufstatter, IU; Sklar, LA; Spragg, RG | 1 |
| Berger, NA; Berger, SJ | 1 |
| Descomps, B; Guérin, MC; Torreilles, J | 1 |
| Kempson, SA | 1 |
| Florin, I; Thelestam, M | 1 |
| Carson, DA; Seto, S; Wasson, DB | 1 |
| Baughman, KL; Feldman, AM; Levine, MA; Van Dop, C | 1 |
| Kabat, MM; Pankiewicz, KW; Watanabe, KA | 1 |
| Chen, XR; Dai, YF; Yu, YN | 1 |
| Dousa, TP; Homma, S; Kiebzak, GM; Kusano, E; Werness, JL; Yusufi, AN | 1 |
| Wiencke, JK | 1 |
| Barankiewicz, J; Cohen, A | 1 |
| Berger, NA; Berger, SJ; Krothapalli, D; Manory, I; Sudar, DC | 1 |
| Brown, EG; Newton, RP; Williams, SP | 1 |
| Gill, DM; Ikejima, M; Marsischky, G | 1 |
| Dousa, TP; Yusufi, AN | 1 |
| Abeles, RH; Alston, TA | 1 |
| Bulanova, LN; Chebotareva, NA; Klinov, SV; Klinova, NI; Kurganov, BI | 1 |
| Bender, DA; Olufunwa, R | 1 |
| Hayward, AR; Herberger, M | 1 |
| Bravo, M; López-Sáez, JF; Pincheira, J | 2 |
| Agarwal, S; Drysdale, BE; Shin, HS | 1 |
| Beijer, NA; Buck, HM; de Kok, PM; Meijer, EM; Sluyterman, LA | 1 |
| Armato, U; Menapace, L; Romano, F | 1 |
| Schwartz, JL; Weichselbaum, RR | 1 |
| Frei, B; Richter, C; Winterhalter, KH | 2 |
| Gowans, BJ; Henderson, JF; Hunting, DJ | 1 |
| Bourke, E; Guntupalli, J; Rogers, A | 1 |
| Christensson, PI; Jonsson, GG; Kjellén, E; Pero, RW | 1 |
| Honma, T; Mandel, P | 1 |
| Johnson, GS; Lucas, DL | 1 |
| Casini, A; Del Principe, D; Di Giulio, S; Finazzi-Agrò, A; Mancuso, G; Menichelli, A | 1 |
| Chapman, BE; Kuchel, PW | 1 |
| You, KS | 1 |
| Kitos, PA; Kushaba-Rugaaju, S | 1 |
| Fukui, S; Hirayama, T; Nohara, M; Uda, K; Yoshida, K | 1 |
| Caplan, AI; Cherney, BW; Midura, RJ | 1 |
| Gill, DM; Pappenheimer, AM; Uchida, T | 1 |
| Bekier, E; Czerwińska, U; Maśliński, C; Szyc, H | 1 |
| Maśliński, C; Mordelet-Dambrine, M; Parrot, JL; Ruff, F; Santais, MC; Wyczolkowska, Y | 1 |
| Bekier, E; Maśliński, C; Szyc, H; Wyczólkowska, J | 1 |
| Fisher, RR; Kaplan, NO | 1 |
| Ammon, HP; Patel, TN; Steinke, J | 1 |
| Chaykin, S; Kuwahara, M | 1 |
| McLaren, J; Ngo, DT; Olivera, BM | 1 |
| Manlapaz-Fernandez, P; Olivera, BM | 1 |
| Lazarus, SS; Shapiro, SH | 1 |
| Craven, DB; Dean, PD; Harvey, MJ; Hollows, ME; Kerfoot, MA; Lowe, CR | 1 |
| Elving, PJ; Santhanam, KS | 1 |
| Koide, SS; Yoshihara, K | 1 |
| Hillyard, D; Olivera, BM; Rechsteiner, MC | 1 |
| Belavady, B; Khan, L; Rao, PU | 1 |
| Härkönen, MH; Kauffman, FC | 1 |
| Blumenstein, M; Raftery, MA | 2 |
| Hillyard, D; Lund, K; Olivera, B; Rechsteiner, M | 1 |
| Leh, F; McManus, TT; Mudd, JB | 1 |
| Blumenthal, HJ; Huettner, CF; Montiel, FA | 1 |
| Rydström, J | 1 |
| Hajra, AK; LaBelle, EF | 1 |
| Oganesian, AA | 1 |
| Chesielski, L; Kempf, E; Lehmann, A; Maitre, M; Mandel, P | 1 |
| Catanzarite, V; Rechsteiner, M | 1 |
| Oguri, S | 1 |
| Buniatian, GKh | 1 |
| Johnson, EC; Kauffman, FC | 1 |
| Maayan, ML; Rosenberg, IN | 1 |
| Sawyer, B; Slater, TF; Sträuli, U | 1 |
| Brohée, H; Whitfield, JF; Youdale, T | 2 |
| Anderson, BM; Reynolds, ML | 2 |
| Burton, RM; Salvador, RA | 1 |
| Abelson, D; Boyle, A; Lee, KW; Parthé, E | 1 |
| Chaykin, S; Murray, KN | 2 |
| Greengard, P; Kalinsky, H; Petrack, B | 2 |
| Greengard, P; Märki, F | 1 |
| Bertazzoni, U; Campagnari, F; Whitfield, JF | 1 |
| Chaykin, S; Gholson, RK; Hadwiger, LA; Waller, GR; Yang, KS | 1 |
| Anderson, BM; Anderson, CD | 2 |
| Gan, M; Gawron, O; Glaid, AJ; Nobel, S | 1 |
| Grunicke, H; Hinz, M; Holzer, H; Liersch, M; Puschendorf, B; Richter, E | 1 |
| Purko, J; Stewart, HB | 1 |
| Chung, AE | 1 |
| Grove, JA; Johnson, RM | 1 |
| Goldstein, II; Roschupkin, DI; Skulachev, VP | 1 |
| Greengard, P; Quinn, GP; Reid, MB | 2 |
| Hayaishi, O; Nakazawa, K; Nishizuka, Y; Ueda, K | 1 |
| Kosche, ER; Lykke, AW | 1 |
| Corsi, L; Pompucci, G; Ricci, C | 1 |
| Maksimova, LV; Rogozkin, VA | 1 |
| Greenbaum, AL; Pinder, S | 2 |
| McDonald, JW; Stewart, HB | 1 |
| Forlano, AJ | 1 |
| Sigman, DS | 1 |
| Hatotani, N; Kawai, H; Matsunaga, R | 1 |
| Anderson, BM; Christian, ST | 1 |
| Sundaram, TK | 1 |
| Fujimura, S; Hasegawa, S; Kawamura, Y; Sugimura, T | 1 |
| Hilz, H; Oldekop, M; Rüter, J; Vachek, H; Wüppen, I | 1 |
| Marchant, KA; Pappas, BC; Pappas, SP | 1 |
| Göbbeler, KH; Woenckhaus, C | 1 |
| Gholson, RK; Shimoyama, M; Yamaguchi, K | 1 |
| Ames, E; Goor, RS; Pappenheimer, AM | 1 |
| Fujimura, S; Hasegawa, S; Shimizu, Y; Sugimura, T | 1 |
| Doly, J; Mandel, P | 1 |
| Bousquet, WF; Miya, TS; Ryan, CF | 1 |
| Hayaishi, O; Ichiyama, A; Nishizuka, Y; Ohtsu, E | 1 |
| Fujimura, S; Hasegawa, S; Shimizu, Y; Sugimura, R | 1 |
| Cooney, DA; Schein, PS; Vernon, ML | 1 |
| Blum, KU; Heim, W; Mehlhorn, D | 1 |
| Anderson, BM; Heitz, JR | 1 |
| Heilmann, HD; Lingens, F | 1 |
| Anderson, BM; Kim, SJ | 1 |
| Furlan, M; Jericijo, M | 1 |
| Hayaishi, O; Honjo, T; Nishizuka, Y; Ueda, K | 1 |
| Eyring, H; Miles, DW; Urry, DW | 1 |
| Chaykin, S; Kim, CS | 1 |
| Deguchi, T; Hayaishi, O; Ichiyama, A; Nishizuka, Y | 1 |
| Hölzel, F; Maass, H; Trobisch, H | 1 |
| Otting, F; Stock, A | 1 |
| Hilz, H; Kittler, M; Lambrecht, J; Römer, V | 1 |
| Ando, F; Toida, I; Yamamoto, S | 1 |
| Kaplan, NO | 1 |
| Fujimura, S; Hasegawa, S; Okuyama, H; Shimizu, Y; Sugimura, T | 1 |
| Honjo, T; Nakazawa, L; Nishizuka, Y; Reeder, RH; Ueda, K | 1 |
| Hagino, Y; Henderson, LM; Lan, SJ; Ng, CY | 1 |
| Land, EJ; Swallow, AJ | 1 |
| Pawan, GL | 1 |
| Johnson, W; Kuchler, RJ; Solotorovsky, M | 1 |
| Dickey, A; McKee, RW; Parks, ME | 1 |
| Anderson, BM; Anderson, CD; Heitz, JR | 1 |
| Pfleiderer, G; Plapp, BV; Woenckhaus, C | 1 |
| Hall, ZW; Lehman, IR; Olivera, BM | 1 |
| Panov, AN | 1 |
| Hayaishi, O; Ichiyama, A; Ijichi, H | 1 |
| Severin, SE | 1 |
| Deitrich, LS; Franklin, L; Martinez, L | 1 |
| Ichiyama, A; Nakamura, S; Nishizuka, Y | 1 |
| Blomquist, CH | 1 |
| Dulin, WE; Wyse, BM | 2 |
| Patel, DJ | 1 |
| Fisher, HF; McGregor, LL | 1 |
| Aexel, RT; Herndon, BL; Kelley, MT; Nicholas, HJ | 1 |
| Lehmann, A; Mandel, P; Simler, S | 1 |
| Cilento, G; Schreier, S | 1 |
| Gholson, RK | 2 |
| Schein, PS | 2 |
| Anraku, Y; Chien, JR; Hall, ZW; Lehman, IR; Olivera, BM | 1 |
| Belinskey, C; Dietrich, LS | 1 |
| Clausen, J; Hustrulid, R | 1 |
| Sakamoto, H; Shimoyama, M; Takeuchi, T; Ueda, I; Yamaguchi, K | 1 |
| Knight, M; Mather, IH | 1 |
| Deroo, J; Gerber, GB; Zicha, B | 1 |
| Shifrin, S | 3 |
| Chakraverty, K; Chaykin, S; King, L; Watson, JG | 1 |
| Häfke, D; Klinger, W; Kober, R; Neugebauer, A; Schirlitz, H; Splinter, FK | 1 |
| Hasegawa, S; Ital, Y; Oikawa, A; Okuyama, H; Sugimura, T | 1 |
| Lovesey, AC | 1 |
| Deroo, J; Gerber, GB | 4 |
| Ryrie, IJ; Scott, KJ | 1 |
| Lojkin, ME | 1 |
| Dietrich, LS; Farinas, B; Franklin, L | 1 |
| Andreoli, AJ; Gholson, RK; Grover, T; Matney, TS | 1 |
| Ababei, L; Filip, M | 2 |
| Brown, RR; Madsen, PO; Price, JM; Wolf, H | 1 |
| Shankaran, R; Venkitasubramanian, TA | 1 |
| Jaffé, ER; Neumann, G | 2 |
| Everse, J; Kaplan, NO; Schichor, S | 1 |
| Johnson, SL; Morrison, DL | 1 |
| Gaut, ZN; Solomon, HM | 2 |
| Amar, A; Bekierkunst, A; Flechner, I | 2 |
| Goor, RS; Maxwell, ES | 1 |
| Chagovets, RV; Khalmuradov, AG; Shushevich, SI | 2 |
| Jeck, R; Woendkhaus, C | 1 |
| Fratta, ID | 1 |
| Calcutt, G; Preece, AV; Ting, SM | 1 |
| Anderton, BH; Rabin, BR | 1 |
| Davis, VE; Walsh, MJ; Yamanaka, Y | 1 |
| Gilleland, MJ; Shore, JD | 1 |
| Anderson, BM; Goodge, BJ | 1 |
| McPherson, A | 1 |
| Fromm, HJ; Rudolph, FB | 1 |
| Greenbaum, AL; Lagunas, R; McLean, P | 1 |
| Kakehi, K; Ohota, M; Shimoyama, M; Ueda, I | 1 |
| Berghäuser, J; Falderbaum, I; Woenckhaus, C | 1 |
| Tatemoto, K; Theorell, H | 1 |
| Bastomsky, CH; McKenzie, JM; Zakarija, M | 1 |
| Burzio, L; Koide, SS | 1 |
| Fynn, GH; Seddon, B | 1 |
| Decker, K; Grotelüschen, H; Liersch, M | 1 |
| Kolarov, J; Subík, J | 1 |
| Clark, JB; Ferris, GM; Pinder, S | 1 |
| Braidman, IP; Rose, DP | 1 |
| Hayaishi, O; Honjo, T; Kato, I; Nishizuka, Y | 1 |
| Calbreath, DF; Joshi, JG | 1 |
| Wolf, H | 1 |
| Imai, T | 1 |
| Apitz, R; Cordes, EH; Mickelson, K; Shriver, K | 1 |
| Eby, D; Kirtley, ME | 1 |
| Brand, L; Heitz, JR | 1 |
| Claussen, U; Grote, W; Heinz, D | 1 |
| Bechara, EJ; Cilento, G | 2 |
| Baird, L; Golden, P; Malaisse, WJ; Malaisse-Lagae, F; Walker, MM | 1 |
| Mattioli, A; Montanaro, L; Sperti, S | 1 |
| Alberti, KG; Schein, PS; Williamson, DH | 1 |
| Henriksen, O; Rideau, C; Smulson, M | 1 |
| Benes, J; Streffer, C | 1 |
| Shigehisa, S; Shimoyama, M; Ueda, I | 1 |
| Francis, SH; Meriwether, BP; Park, JH | 2 |
| Guilbert, CC; Johnson, SL | 1 |
| Grunicke, H; Keller, J; Liersch, M | 2 |
| Ito, T; Murashima, R; Shimoyama, M; Tanigawa, Y; Tomoda, T; Ueda, I | 1 |
| Jeck, R; Woenckhaus, C | 1 |
| Cowger, ML; Labbe, RF; Nielsen, LD; Nutter, J | 1 |
| Anderson, BM; Yuan, JH | 3 |
| Witholt, B | 1 |
| Chaykin, S; Collins, PB | 2 |
| Allen, SH; Patil, JR | 1 |
| Bhavnani, BR; Shah, KN; Solomon, S | 1 |
| Ito, T | 1 |
| Kasărov, LB; Moat, AG | 4 |
| Brown, B; Hollis, D; McDonald, G; Walter, C | 1 |
| Hayakawa, T; Uehara, K | 1 |
| Fujimoto, S; Uehara, K | 1 |
| Gill, DM | 1 |
| Badalian, RB; Buniatian, HCh; Simonian, AA; Stepanian, RA | 1 |
| Andreoli, AJ; Bloom, R; Grover, TA; Okita, TW | 1 |
| Burzio, L; Koide, SS; Miura, S | 1 |
| Henderson, LM; Lan, SJ; Lin, LF; Richardson, AH | 1 |
| Henderson, LM; Lin, LF | 1 |
| Neta, P | 1 |
| Brown, RR; Hankes, LV; Jansen, CR; Leklem, J; Mekel, RC | 1 |
| Dinius, LL; Gill, DM | 1 |
| Górny, R; Sokal, JA; Szyc, M; Tarkowski, S; Wrońska-Nofer, T | 1 |
| Scholz, G; Streffer, C | 1 |
| Krämer, W; Scherer, B | 1 |
| Audette, RC; Purvis, JL; Worthen, LR; Youngken, HW | 1 |
| Toida, I | 1 |
| Kerr, TJ; Tritz, GJ | 1 |
| Bernofsky, C; Pankow, M | 1 |
| Johnson, PL; Maier, CA; Paul, IC | 1 |
| Frank, JK; Johnson, PL; Paul, IC | 1 |
| Frank, JK; Paul, IC; Thayer, NN | 1 |
| Bryson, TA; Dunlap, RB; Ellis, PD; Fisher, RR; Williams, TJ; Zens, AP | 1 |
| Gamble, JG; Max, SR; Rifenberick, DH | 1 |
| Boers, W; Verhoeven, JW | 1 |
| Anderson, T; Cooney, DA; McMenamin, MG; Schein, PS | 1 |
| Burkhalter, A; MacGregor, JT | 1 |
| Bartholmes, P; Durchschlag, H; Jaenicke, R | 1 |
| Benacerraf, B; Burakoff, SJ; Martz, E | 1 |
| Shall, S; Stone, PR | 1 |
| Kim, JC; Plapp, BV; Zoltobrocki, M | 1 |
| Chung, DW; Collier, RJ; Kandel, J | 1 |
| Fukuba, R | 1 |
| Ise, N; Okubo, T | 1 |
| Leroi, GE; Patrick, DM; Wilson, JE | 1 |
| Eriksson, CJ | 1 |
| Heik, P; Jeck, R; Woenckhaus, C | 1 |
| Altus, MS | 1 |
| Beisel, P; Streffer, C | 1 |
| Kaplan, NO; Lee, CY; Oppenheimer, NJ | 1 |
| Hilz, H; Kuhn, C | 1 |
| Iakusheva, IA; Ital'ianskaia, IuV; Katkova, NB; Khalfer, ESh; Loginova, LA | 1 |
| de Iglesias, RE; Iglesias-Rozas, JR | 1 |
| Berne, C; Gunnarsson, R; Hellerström, C | 1 |
| Movsesian, SG | 1 |
| Burdette, KE; Kidwell, WR | 1 |
| Gross, D | 1 |
| benaguid, A; Grunicke, H; Keller, TH | 1 |
| Benaguid, A; Grunicke, H; Keller, HJ; Liersch, M | 1 |
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| Auchus, RJ; Braun, RT; Breynaert, E; Casalino, LP; Chandran, CV; Chauvin, JR; De Man, WL; Delcour, JA; Ding, S; He, L; Huang, X; Huang, Z; Im, SC; Jung, HY; Khodade, VS; Krishnarjuna, B; Li, L; Li, N; Li, Q; Marte, J; Martens, JA; Myslinski, Z; Pratt, DA; Radhakrishnan, S; Ramamoorthy, A; Ravula, T; Rodriguez, D; Song, L; Toscano, JP; Unruh, MA; Wang, X; Wang, Z; Wouters, AGB; Wu, Z; Yu, S; Zhang, T; Zhang, W; Zhou, J | 1 |
| Liu, KJ; Wang, XY; Xiang, B; Zhang, FY | 1 |
| Cen, Y; Donu, D; Sharma, C | 2 |
| Dymkowska, D; Mateuszuk, Ł; Stępińska, O; Zabłocki, K | 1 |
| Altaf, F; Hollmann, F; Lauterbach, L; Leimkühler, S; Lenz, O; Lonsdale, TH; Nicholson, J; Paul, CE; Preissler, J; Reeve, HA; Vincent, KA | 1 |
| Li, Q; Meng, D; You, C | 1 |
| Barr, DB; Batross, J; Baumert, BO; D'Souza, P; Fiedler, N; Kaewthit, K; Kohsuwan, K; Liang, D; Mangklabruks, A; Naksen, W; Panuwet, P; Pingwong, S; Prapamontol, T; Promkam, N; Ryan, PB; Sittiwang, S; Suttiwan, P; Tan, Y; Yakimavets, V | 1 |
| Liu, Q; Liu, R; Lu, Q; Pu, Y; Wang, S; Yin, L; Yu, X; Zhang, H; Zhang, Y; Zhao, C; Zhou, J | 1 |
| Allgeier, AM; Hutchison, JM; Sharma, VK | 1 |
| Chen, C; Hao, K; Huang, H; Liu, Z; Reynolds, GP; Shu, C; Wang, G; Wang, H; Xie, X; Xu, R; Xu, S; Zhang, Y; Zhou, Y | 1 |
| Canto, C; Cercillieux, A; Ciarlo, E; Giroud-Gerbetant, J; Jacot, G; Joffraud, M; Métairon, S; Ratajczak, J; Rumpler, M; Sambeat, A; Sanchez-Garcia, JL; Valera-Alberni, M; Zollinger, A | 1 |
| Bermúdez, LG; Bernal, C; Cañas, A; González, D; Henríquez, B; Morales-Ruíz, T; Rodríguez, S; Rojas, A | 1 |
| He, T; Huang, X; Li, M; Li, X; Liao, X; Liu, R; Qiu, X; Tang, Q | 1 |
| Essert, A; Güner, S; Lommes, P; Sieber, V; Zachos, I | 1 |
| Kong, LH; Liu, TY; Qin, JY; Xu, WN; Yao, QS; Zhang, XH | 1 |
| Borrelli, M; Kahn, B; Libby, T | 1 |
| Agar, NYR; Asara, JM; Bai, P; Baquer, G; Batalini, F; Bret-Mounet, VC; Cyr, AM; Eikesdal, HP; Heng, YJ; Ke, S; Pinto, J; Regan, MS; Sonzogni, O; Stopka, SA; Thavamani, A; Tian, S; Vandal, S; Wang, D; Wang, L; Wang, Q; Wulf, GM; Yuan, M | 1 |
| Antosiewicz, J; Cieminski, K; Dzik, KP; Flis, DJ; Kaczor, JJ; Wieckowski, MR; Ziolkowski, W | 1 |
| Buckley, DP; Migaud, ME; Tanner, JJ | 1 |
| Fathi, M; Hajibeygi, R; Jazi, K; Klegeris, A; McElhinney, A; Sayehmiri, F; Shool, S; Sodeifian, F; Tavasol, A; Tavirani, MR; Vakili, K; Yaghoobpoor, S | 1 |
| Antipova, M; Gambaryan, S; Khodorkovskiy, M; Kropotov, A; Kulikova, V; Migaud, ME; Nerinovski, K; Nikiforov, A; Plusnina, A; Solovjeva, L; Sudnitsyna, J; Svetlova, M; Yakimov, A; Ziegler, M | 1 |
| Goncharova, I; Martynov, M; Mukhametdinova, D; N Yu, N; Osipova, S; Podyacheva, E; Sviridov, E; Toropova, Y; V A, V; Zelinskaya, I | 1 |
| Bazhin, A; Cantó, C; Coukos, G; Giordano Attianese, GMP; Goun, E; Irving, M; Joffraud, M; Khodakivskyi, P; Maric, T; Mikhaylov, G; Solodnikova, E; Yevtodiyenko, A | 1 |
| Bozon, K; Bröer, S; Cuny, H; Dunwoodie, SL; Kirk, RB; Sheng, DZ | 1 |
| Pan, D; Su, M; Sun, G; Wang, N; Wang, S; Wang, X; Yan, Q | 1 |
| Kirilin, E; Kopylov, K; Švedas, V | 1 |
| Baur, JA; Bhat, YR; Chellappa, K; Chu, Q; Cox, T; Davidson, SM; Descamps, HC; Hayat, F; Jankowski, C; Ji, L; Lingala, SR; Lu, W; Makarov, M; McReynolds, MR; Migaud, ME; Mukherjee, S; Rabinowitz, JD; Shima, RT; Thaiss, CA; Zeng, X | 1 |
| Braidy, N; Helman, T | 1 |
| Gazzaniga, FS | 1 |
| Smolin, AG | 1 |
| Ding, Y; Fang, EF; Gao, M; Gu, Y; Hu, Q; Li, Q; Li, W; Ma, S; Pan, J; Pang, N; Sun, Y; Xiao, Y; Yang, L; Zhang, Z; Zhou, Y | 1 |
| Lei, ZX; Li, YQ; Lin, YW; Zhou, XD | 1 |
| Brasen, CL; Erbs, E; Lund, AM; Rasmussen, M | 1 |
| Chabloz, S; Ewald, CY; Lapides, RA; Roider, E; Sharma, A | 1 |
| Hagström, A; Jusseaume, K; Lardner, E; Stålhammar, G; Tribble, JR; Williams, PA; Wong, RC | 1 |
| Pfund, B; Schreier, MR; Steffen, DM; Wenger, OS | 1 |
| Ackerman-Berrier, M; Christie, N; Fu, J; Gordon-Blake, J; Knowles, NG; Krider, IS; Laham, MS; Lee, H; Musku, SR; Penton, C; Ratia, KM; Shen, Z; Thatcher, GRJ; Velma, GR; Xiong, R | 1 |
| Bain, AJ; Blacker, TS; Duchen, MR | 1 |
| Huang, L; Liao, W; Lilley, DMJ; Lin, X; Peng, X | 1 |
| Cheng, J; Liu, R; Ma, H; Yu, J; Zhao, Y; Zhu, X | 1 |
| Chakraborty, SS; Coen, PM; DeLany, JP; DeNicola, GM; Dutta, T; Falzone, A; Gardell, SJ; Kapoor, N; Mathew, M; Prieto-Farigua, N; Smith, SR; Ward, NP | 1 |
| Costa, VP; Goulart Nacácio E Silva, S; Occhiutto, ML | 1 |
| Huang, Z; Li, N; Song, F; Wang, X; Zhou, J | 1 |
| Chen, M; Chen, Y; Ding, Y; Fang, EF; Gu, Y; Hu, Q; Li, Q; Li, W; Pang, N; Pei, L; Sun, Y; Xiao, Y; Yang, L; Ye, M; Zhang, Z; Zhou, Y | 1 |
| Almeida, KH; Avalos-Irving, L; Berardinelli, S; Chauvin, K; Yanez, S | 1 |
| Beltrà, M; Corrà, S; Fornelli, C; Hsu, MY; Hulmi, JJ; Kivelä, R; Moletta, L; Penna, F; Pirinen, E; Pöllänen, N; Porporato, PE; Sandri, M; Sartori, R; Tonttila, K; Viscomi, C; Zampieri, S | 1 |
| Claassens, NJ; Partipilo, M; Slotboom, DJ | 1 |
| Acharjee, A; Anderson, DG; Astuti, D; Barrett, T; Buganim, Y; Cartwright, D; Chipara, M; Cohen, MA; Frickel, EM; Gsponer, J; Huerta-Uribe, A; Hughes, GW; Jaenisch, R; Kataura, T; Kauffman, KJ; Korolchuk, VI; Korsgen, ME; Kuechler, ER; Lara-Reyna, S; Lavery, GG; Maddocks, ODK; Otten, EG; Palhegyi, AM; Panda, PK; Roberts, J; Rosenstock, TR; Sahay, G; Sarkar, S; Sedlackova, L; Seranova, E; Silva, LFSE; Sun, C; Tennant, DA; Torresi, J; Trushin, S; Trushina, E; Wang, H; Ward, C; Zatyka, M; Zhang, S | 1 |
| Barbarroja, N; Burón, MI; Calvo, J; Cerdó, T; Collantes-Estevez, E; Del Carmen Abalos-Aguilera, M; Escudero-Contreras, A; González-Reyes, JA; la Rosa, IA; Llamas-Urbano, A; Lopez-Pedrera, C; Moreno, JA; Muñoz-Barrera, L; Ortega-Castro, R; Pérez-Rodriguez, M; Perez-Sanchez, C; Ruiz-Vilchez, D; Sánchez-Mendoza, LM; Villalba, JM | 1 |
| Cordoba-Chacon, J; Griffiths, A; Huang, R; Iyamu, ID; Lee, SM; Song, Q; Song, Z; Wang, J | 1 |
| Borén, J; Doganay, HL; Jin, H; Li, X; Mardinoglu, A; Nielsen, J; Ozturk, G; Turkez, H; Uhlén, M; Yang, H; Zhang, C | 2 |
| Alegre, GFS; Pastore, GM | 1 |
| Cui, X; Curran, CS; Demirkale, CY; Dougherty, EJ; Gamble, T; Jeakle, M; Li, Y; Torabi-Parizi, P | 1 |
| Balawejder, M; Piechowiak, T; Skóra, B | 1 |
| Alonso, N; Julve, J; Martinez-Santos, P; Mauricio, D; Niño-Narvión, J; Ramos-Molina, B; Rojo-López, MI; Rossell, J; Ruiz-Alcaraz, AJ | 1 |
| Dellinger, RW; Dhuguru, J; Migaud, ME | 1 |
| Boehm, T; Brankovic, J; Gludovacz, E; Jilma, B; Klavins, K; Sednev, M; Weiss-Tessbach, M | 1 |
| Damgaard, MV; Treebak, JT | 1 |
| Degano, M; Galasyn, GS; Kerin, F; Nyitray, MM; Parkin, DW; Patrone, M; Stockman, BJ | 1 |
| Bifulco, E; Ferrario, E; Houry, D; Kursula, P; Niere, M; Raasakka, A; Ziegler, M | 1 |
| Bruggeman, C; Gregurash, K; Hickey, DP | 1 |
| Alonso, N; Camacho, M; Del Olmo, TV; Diarte-Añazco, EMG; Julián, MT; Julve, J; Martinez-Santos, P; Mauricio, D; Méndez-Lara, KA; Muñoz, JP; Niño-Narvión, J; Rossell, J; Rotllan, N; Torres-Méndez, JK | 1 |
| Agarwal, A; Chinta, KC; Glasgow, JN; Lumamba, K; Nadeem, S; Naidoo, T; Nargan, K; Pacl, HT; Reddy, VP; Sevalkar, RR; Steyn, AJC | 1 |
| Gasior, FM; Justice, CN; Lee, C; Li, J; Lin, S; O'Donnell, JM; Vanden Hoek, TL; Wang, H; Zhu, X | 1 |
| Goswami, L; Kafle, SR; Kim, BS; Kushwaha, A; Maharjan, A | 1 |
| Camacho, M; Julve, J; Niño-Narvión, J | 1 |
| Ferrario, E; Kallio, JP; Strømland, Ø; Ziegler, M | 1 |
| Kumar, H; Leimkühler, S | 1 |
| Af Geijerstam, SA; Berven, H; Dölle, C; Haugarvoll, K; Kverneng, S; Sheard, E; Skeie, GO; Søgnen, M; Tzoulis, C | 1 |
| Abell, C; Blundell, TL; Ciulli, A; Smith, AG; Williams, G | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
81 review(s) available for nad and niacinamide
| Article | Year |
|---|---|
Diphtheria toxin: mode of action and structure.
Topics: Adenosine Diphosphate; Amino Acid Sequence; Animals; Binding Sites; Cell-Free System; Corynebacterium diphtheriae; Culture Techniques; Diphtheria; Diphtheria Antitoxin; Diphtheria Toxin; Diphtheria Toxoid; Electrophoresis, Polyacrylamide Gel; Genes; Glycoside Hydrolases; Humans; Immunodiffusion; Lysogeny; Molecular Weight; NAD; Niacinamide; Peptide Elongation Factors; Peptides; Protein Biosynthesis | 1975 |
Significance of V-factor dependency in the taxonomy of Haemophilus species and related organisms.
Topics: Actinobacillus; Haemophilus; NAD; Niacinamide; Nicotinamide Mononucleotide; Pasteurella; Pasteurellaceae; Pyridines; Pyridinium Compounds; Structure-Activity Relationship | 1990 |
Stereospecificity for nicotinamide nucleotides in enzymatic and chemical hydride transfer reactions.
Topics: Adenosine Monophosphate; Catalysis; Coenzymes; Crystallography; Dihydropyridines; Fluorescence; Glycosides; Hydrogen; Magnetic Resonance Spectroscopy; Molecular Conformation; NAD; NADP; Niacinamide; Nucleotides; Oxidation-Reduction; Protein Binding; Pyridines; Substrate Specificity; Terminology as Topic | 1985 |
Diphtheria toxin, protein synthesis, and the cell.
Topics: Adenosine Diphosphate; Binding Sites; Carbon Isotopes; Cell Membrane Permeability; Cells; Cross Reactions; Diphtheria; Diphtheria Antitoxin; Diphtheria Toxin; Disulfides; Electrophoresis, Polyacrylamide Gel; Epitopes; Guanosine Triphosphate; HeLa Cells; Humans; Immunodiffusion; In Vitro Techniques; NAD; Niacinamide; Peptide Elongation Factors; Peptide Hydrolases; Peptides; Protein Biosynthesis; Ribosomes; RNA, Transfer; Trypsin | 1973 |
[Mechanisms of ammonia formation in the brain].
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Amino Acid Oxidoreductases; Amino Acids; Ammonia; Animals; Aspartic Acid; Brain; Brain Chemistry; Deamination; Dogs; Flavin-Adenine Dinucleotide; Fumarates; Glutamate Dehydrogenase; Glutaminase; Glutamine; Guanosine Triphosphate; Inosine Nucleotides; Mitochondria; Monoamine Oxidase; NAD; NADP; Nerve Tissue Proteins; Niacinamide; Oxidation-Reduction; Oxygen Consumption; Rats | 1973 |
Excretion of tryptophan metabolites as affected by pregnancy, contraceptive steroids, and steroid hormones.
Topics: Androsterone; Animals; Contraceptives, Oral; Enzyme Induction; Estradiol; Female; Humans; Hydrocortisone; Kynurenine; Liver; Male; Megestrol; NAD; Niacinamide; ortho-Aminobenzoates; Pregnancy; Pyridoxine; Rats; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1971 |
Utilization of niacin and niacinamide for NAD formation in rat liver.
Topics: Adenosine Triphosphate; Animals; Azaserine; Carbon Isotopes; Cats; Female; Liver; Mice; NAD; Niacinamide; Nicotinic Acids; Perfusion; Rats | 1972 |
[Naturally occurring material containing pyridine and its biosynthesis].
Topics: Alkaloids; Bacteria; Carbon Radioisotopes; Isomerism; Molecular Conformation; NAD; Niacinamide; Nicotinic Acids; Oxygen Consumption; Picolinic Acids; Plants; Pyridines; Species Specificity; Streptomyces; Structure-Activity Relationship; Terpenes; Tryptophan | 1970 |
[Physiopathology of the nutritional imbalance caused by deficiency of vitamin PP].
Topics: Amino Acids; Animals; Avitaminosis; Humans; NAD; NADP; Niacinamide; Pellagra; Tryptophan | 1968 |
Physiology aspects of pyridine nucleotide regulation in mammals.
Topics: Adrenal Cortex Hormones; Animals; Female; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Hyperthyroidism; Hypophysectomy; Liver; Mice; Mitochondria; NAD; NADP; Neoplasms; Niacinamide; Poly Adenosine Diphosphate Ribose; Rats | 1980 |
Evaluating the role of niacin in human carcinogenesis.
Topics: Anticarcinogenic Agents; Diet; Erythrocytes; Humans; NAD; Niacin; Niacinamide; Poly Adenosine Diphosphate Ribose; Tryptophan | 1995 |
Inducible protective processes in animal systems. X. Influence of nicotinamide in methyl methanesulfonate-adapted mouse bone marrow cells.
Topics: Adaptation, Physiological; Alkylating Agents; Animals; Bone Marrow Cells; Chromosome Aberrations; DNA Repair; Drug Interactions; Drug Resistance; Enzyme Inhibitors; Male; Methyl Methanesulfonate; Mice; Mitotic Index; Mutagenicity Tests; Mutagens; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases | 2002 |
Medicinal chemistry of nicotinamide in the treatment of ischemia and reperfusion.
Topics: Animals; Humans; Ischemia; MELAS Syndrome; NAD; Niacinamide; Oxidative Stress; Poly(ADP-ribose) Polymerases; Reperfusion Injury | 2002 |
PATHWAYS OF OXIDATION OF REDUCED NICOTINAMIDE NUCLEOTIDES IN CEREBRAL TISSUE.
Topics: Biological Transport; Brain; Metabolism; Microsomes; Mitochondria; NAD; NADP; Nerve Tissue; Niacinamide; Nucleotides; Oxidation-Reduction; Oxidoreductases | 1964 |
SIR2: the biochemical mechanism of NAD(+)-dependent protein deacetylation and ADP-ribosyl enzyme intermediates.
Topics: Acetylation; Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Antigens, CD; Catalysis; Histone Deacetylases; Hydrolysis; Kinetics; Models, Molecular; NAD; Niacinamide; O-Acetyl-ADP-Ribose; Protein Processing, Post-Translational; Protein Structure, Tertiary; Saccharomyces cerevisiae; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins | 2004 |
Navigating novel mechanisms of cellular plasticity with the NAD+ precursor and nutrient nicotinamide.
Topics: Aging; Animals; Apoptosis; Apoptotic Protease-Activating Factor 1; Caspases; Cell Survival; Endothelial Cells; Humans; Inflammation; Intracellular Signaling Peptides and Proteins; Mitochondria; NAD; Neurons; Niacinamide; Phosphatidylserines; Poly(ADP-ribose) Polymerases; Proteins; Tumor Necrosis Factor-alpha | 2004 |
Cell Life versus cell longevity: the mysteries surrounding the NAD+ precursor nicotinamide.
Topics: Animals; Cell Death; Cells; Humans; NAD; Niacinamide; Poly(ADP-ribose) Polymerases; Signal Transduction; Stem Cells | 2006 |
Nampt/PBEF/Visfatin: a regulator of mammalian health and longevity?
Topics: Aging; Animals; Caloric Restriction; Longevity; Mammals; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Pentosyltransferases; Saccharomyces cerevisiae; Sirtuins | 2006 |
NAD+ utilization in Pasteurellaceae: simplification of a complex pathway.
Topics: Animals; Bacterial Proteins; Humans; NAD; Niacinamide; Pasteurellaceae; Pyridinium Compounds; Repressor Proteins | 2006 |
NAD+ metabolism in health and disease.
Topics: ADP Ribose Transferases; ADP-ribosyl Cyclase; Aging; Animals; Candida glabrata; Candidiasis; Humans; Lipids; NAD; Neurodegenerative Diseases; Niacinamide; Poly(ADP-ribose) Polymerases; Sirtuins | 2007 |
Pharmacological targeting of IDO-mediated tolerance for treating autoimmune disease.
Topics: Animals; Autoimmune Diseases; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; NAD; Niacin; Niacinamide | 2007 |
NAD+ and vitamin B3: from metabolism to therapies.
Topics: Animals; Humans; NAD; Niacinamide; Pyridinium Compounds; Signal Transduction | 2008 |
Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition.
Topics: Animals; Caloric Restriction; Candida glabrata; Dietary Supplements; Dyslipidemias; Humans; NAD; Niacin; Niacinamide; Nutritional Requirements; Pyridinium Compounds | 2008 |
Enzymology of mammalian NAD metabolism in health and disease.
Topics: Amide Synthases; Animals; Humans; Mammals; NAD; NADP; Niacin; Niacinamide; Nicotinamide-Nucleotide Adenylyltransferase; Phosphotransferases (Alcohol Group Acceptor); Reference Values | 2008 |
Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases.
Topics: Animals; Humans; Mammals; Molecular Structure; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase | 2009 |
Emerging roles of NAD+ and its metabolites in cell signaling.
Topics: Adenosine Diphosphate Ribose; Animals; Cell Physiological Phenomena; Energy Metabolism; Humans; NAD; NADP; Niacinamide; Second Messenger Systems; Signal Transduction | 2009 |
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase, new insights into an ancient enzyme.
Topics: Adenosine Triphosphate; Animals; Binding Sites; DNA Repair; Humans; Isoenzymes; Models, Molecular; Molecular Chaperones; Molecular Sequence Data; NAD; Niacinamide; Nicotinamide-Nucleotide Adenylyltransferase; Poly(ADP-ribose) Polymerases; Protein Conformation; Substrate Specificity; Tissue Distribution | 2009 |
Structural basis for sirtuin function: what we know and what we don't.
Topics: Amino Acid Sequence; Animals; Catalytic Domain; Humans; Models, Molecular; Molecular Sequence Data; Molecular Structure; NAD; Niacinamide; Protein Conformation; Protein Folding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Sirtuins; Zinc | 2010 |
NAD(+) -dependent histone deacetylases (sirtuins) as novel therapeutic targets.
Topics: Animals; Epigenesis, Genetic; HIV Infections; Humans; Inhibitory Concentration 50; Models, Chemical; NAD; Neoplasms; Niacinamide; Protein Binding; Resveratrol; Signal Transduction; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Stilbenes | 2010 |
Biochemical effects of SIRT1 activators.
Topics: Animals; Cardiotonic Agents; Energy Metabolism; Enzyme Activation; Heterocyclic Compounds, 4 or More Rings; Humans; Insulin Resistance; Learning; Longevity; Memory; Mice; Models, Biological; NAD; Neoplasms; Niacinamide; O-Acetyl-ADP-Ribose; Resveratrol; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 1; Stilbenes | 2010 |
Sirtuin chemical mechanisms.
Topics: Acetylation; Adenosine Diphosphate Ribose; Animals; Benzimidazoles; Humans; Imidoesters; Lysine; Models, Biological; Molecular Structure; NAD; Niacinamide; Plasmodium falciparum; Saccharomyces cerevisiae; Sirtuins; Trypanosoma brucei brucei | 2010 |
Vitamin B3, the nicotinamide adenine dinucleotides and aging.
Topics: ADP Ribose Transferases; Aging; Animals; Apoptosis; Cell Cycle; Cell Physiological Phenomena; DNA Damage; Energy Metabolism; Humans; NAD; Niacinamide; Oxidation-Reduction; Signal Transduction; Sirtuins | 2010 |
NAMPT in regulated NAD biosynthesis and its pivotal role in human metabolism.
Topics: Animals; Humans; Inflammation; Insulin; Insulin Secretion; Longevity; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase | 2011 |
Sirtuins: NAD(+)-dependent deacetylase mechanism and regulation.
Topics: Acetylation; Animals; Humans; Imidoesters; Models, Molecular; NAD; Niacinamide; Sirtuins | 2012 |
Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Energy Metabolism; Humans; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Mitochondrial Turnover; Muscle, Skeletal; NAD; Neuroprotective Agents; Niacinamide; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds | 2013 |
The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging.
Topics: Aging; Energy Metabolism; Glycolysis; Humans; Metabolome; NAD; Niacinamide; Oxidative Phosphorylation; Oxidative Stress; Skin; Ultraviolet Rays | 2014 |
NAD homeostasis in the bacterial response to DNA/RNA damage.
Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; Bacteria; DNA Damage; DNA Ligases; DNA, Bacterial; Group III Histone Deacetylases; Homeostasis; NAD; Niacinamide; RNA, Bacterial | 2014 |
Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells.
Topics: Animals; Apoptosis; Humans; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Poly (ADP-Ribose) Polymerase-1; Sirtuin 1; Transcription Factor RelA | 2017 |
NAD
Topics: Aging; Humans; Incidence; Life Expectancy; Longevity; NAD; Neoplasms; Niacinamide; Nicotinamide Mononucleotide; Vitamin B Complex | 2017 |
NAD
Topics: Aging; Animals; Humans; NAD; Niacinamide; Nicotinamide Mononucleotide; Pyridinium Compounds | 2018 |
A need for NAD+ in muscle development, homeostasis, and aging.
Topics: Aging; Animals; Homeostasis; Humans; Intracellular Space; Muscle Development; Muscle Proteins; Muscle, Skeletal; Muscular Diseases; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Pyridinium Compounds; Regeneration; Signal Transduction | 2018 |
Rejuvenating Aged Hematopoietic Stem Cells Through Improvement of Mitochondrial Function.
Topics: Adenosine Triphosphate; Animals; Cellular Senescence; Hematopoietic Stem Cells; Humans; Mitochondria; NAD; Niacin; Niacinamide; Sirtuins | 2018 |
Vitamin B3 in Health and Disease: Toward the Second Century of Discovery.
Topics: Adenosine Diphosphate Ribose; Humans; NAD; Niacin; Niacinamide | 2018 |
Biomimetic cofactors and methods for their recycling.
Topics: Biocatalysis; Biomimetics; NAD; Niacinamide | 2019 |
How to make the reducing power of H
Topics: Biotransformation; Cupriavidus necator; Hydrogen; Metabolic Engineering; NAD; Niacinamide; Oxidation-Reduction | 2019 |
Multi-targeted Effect of Nicotinamide Mononucleotide on Brain Bioenergetic Metabolism.
Topics: Animals; Brain; Humans; Hydrolases; Mitochondria; NAD; Neurodegenerative Diseases; Niacinamide; Nicotinamide Mononucleotide | 2019 |
Nicotinamide adenine dinucleotide emerges as a therapeutic target in aging and ischemic conditions.
Topics: Aging; Drug Discovery; Humans; Ischemia; Mitochondria; NAD; Niacinamide; Nicotinamide Mononucleotide; Pyridinium Compounds | 2019 |
Biologically generated carbon dioxide: nature's versatile chemical strategies for carboxy lyases.
Topics: Animals; Biotin; Carbon; Carbon Dioxide; Carboxy-Lyases; Carboxylic Acids; Catalysis; Coenzymes; Humans; Metabolic Networks and Pathways; NAD; Neurotransmitter Agents; Niacinamide; Pyruvate Decarboxylase; Zinc | 2020 |
Role of Nicotinamide in Genomic Stability and Skin Cancer Chemoprevention.
Topics: Animals; Energy Metabolism; Genomic Instability; Humans; Immunosuppression Therapy; NAD; Niacinamide; Skin Aging; Skin Neoplasms; Ultraviolet Rays | 2019 |
NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis.
Topics: Aging; Animals; Humans; Inflammation; Mice; NAD; Neurodegenerative Diseases; Niacinamide; Nicotinamide Mononucleotide; Oxidative Stress; Pyridinium Compounds; Rats; Risk Assessment | 2020 |
NAD
Topics: Animals; Chemical Warfare Agents; Dietary Supplements; Humans; Mustard Gas; NAD; Niacinamide; Oxidative Stress; Poly(ADP-ribose) Polymerases; Reactive Nitrogen Species; Sirtuins | 2020 |
The Role of Nicotinamide in Cancer Chemoprevention and Therapy.
Topics: Clinical Trials, Phase III as Topic; Humans; NAD; Neoplasm Proteins; Neoplasms; Niacinamide; Poly (ADP-Ribose) Polymerase-1; Sirtuin 1 | 2020 |
Nicotinamide riboside-A missing piece in the puzzle of exercise therapy for older adults?
Topics: Aged; Animals; Exercise Therapy; Humans; Muscle, Skeletal; NAD; Niacinamide; Pyridinium Compounds | 2020 |
Implications of NAD
Topics: ADP-ribosyl Cyclase; Aging; Animals; Biosynthetic Pathways; Carboxy-Lyases; Clinical Trials as Topic; Enzyme Inhibitors; Gastrointestinal Microbiome; Humans; NAD; Niacinamide; Nicotinamide Mononucleotide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Probiotics; Pyridinium Compounds; Sirtuins; Translational Research, Biomedical | 2020 |
Engineering natural and noncanonical nicotinamide cofactor-dependent enzymes: design principles and technology development.
Topics: Industrial Development; NAD; NADP; Niacinamide | 2020 |
Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation.
Topics: Adipose Tissue; Animals; Epigenesis, Genetic; Humans; Insulin Resistance; Liver; NAD; Neoplasms; Niacinamide; Nicotinamide N-Methyltransferase; Obesity; S-Adenosylmethionine | 2021 |
Protective Effects of Nicotinamide Adenine Dinucleotide and Related Precursors in Alzheimer's Disease: A Systematic Review of Preclinical Studies.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Apoptosis; Behavior, Animal; Disease Models, Animal; Drug Evaluation, Preclinical; Energy Metabolism; Mice; Mice, Transgenic; Mitochondria; NAD; Neuroinflammatory Diseases; Neuroprotective Agents; Niacin; Niacinamide; Oxidative Stress; Protein Aggregation, Pathological; Rats; Synapses; tau Proteins | 2021 |
Advances in NAD-Lowering Agents for Cancer Treatment.
Topics: Animals; Antineoplastic Agents; Biosynthetic Pathways; Cell Death; Cell Line, Tumor; Cell Survival; Cytokines; DNA Damage; DNA Repair; Humans; NAD; Neoplasms; Niacin; Niacinamide; Nicotinamide Phosphoribosyltransferase; Oxidative Stress | 2021 |
Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer.
Topics: Humans; Methylation; NAD; Neoplasm Proteins; Neoplasms; Neoplastic Stem Cells; Niacinamide; Nicotinamide N-Methyltransferase | 2021 |
Nicotinamide mononucleotide: An emerging nutraceutical against cardiac aging?
Topics: Aging; Dietary Supplements; Humans; NAD; Niacinamide; Nicotinamide Mononucleotide | 2021 |
Nicotinamide Riboside for the Prevention and Treatment of Doxorubicin Cardiomyopathy. Opportunities and Prospects.
Topics: Animals; Antibiotics, Antineoplastic; Biomarkers; Cardiomyopathies; Cardiotonic Agents; Cardiotoxicity; Disease Management; Disease Models, Animal; Disease Susceptibility; Doxorubicin; Humans; Metabolic Networks and Pathways; NAD; Niacinamide; Oxidative Stress; Pyridinium Compounds; Signal Transduction; Sirtuins | 2021 |
Model of Streptozotocin-nicotinamide Induced Type 2 Diabetes: a Comparative Review.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Humans; NAD; Niacinamide; Poly(ADP-ribose) Polymerases; Rats; Streptozocin | 2022 |
A systems-approach to NAD+ restoration.
Topics: Aging; Humans; NAD; Niacinamide; Reproducibility of Results | 2022 |
NAMPT: A critical driver and therapeutic target for cancer.
Topics: Animals; Cytokines; Mammals; NAD; Neoplasms; Niacinamide; Nicotinamide Phosphoribosyltransferase | 2022 |
COVID-19: Are We Facing Secondary Pellagra Which Cannot Simply Be Cured by Vitamin B3?
Topics: COVID-19; Humans; NAD; Niacin; Niacinamide; Pellagra; SARS-CoV-2 | 2022 |
The Role of NAD
Topics: Animals; Female; Glaucoma; Humans; Mice; NAD; Niacinamide; Optic Nerve Diseases; Retinal Ganglion Cells | 2022 |
Balancing NAD
Topics: Animals; Disease Models, Animal; Mice; NAD; Niacinamide; Pyridinium Compounds | 2022 |
Supplementation with NAD
Topics: Animals; Cognitive Dysfunction; Dietary Supplements; Humans; NAD; Niacin; Niacinamide; Nicotinamide Mononucleotide | 2022 |
Redox Biocatalysis: Quantitative Comparisons of Nicotinamide Cofactor Regeneration Methods.
Topics: Biocatalysis; NAD; NADP; Niacinamide; Oxidation-Reduction; Oxidoreductases; Regeneration | 2022 |
A Narrative Review of Nicotinamide Adenine Dinucleotide (NAD)+ Intermediates Nicotinamide Riboside and Nicotinamide Mononucleotide for Keratinocyte Carcinoma Risk Reduction.
Topics: Carcinoma; Humans; Keratinocytes; NAD; Niacinamide; Nicotinamide Mononucleotide; Pyridinium Compounds; Risk Reduction Behavior | 2022 |
Emerging Role of Nicotinamide Riboside in Health and Diseases.
Topics: Humans; NAD; Niacinamide; Pyridinium Compounds; Vitamins | 2022 |
Dynamic changes in metabolites of the kynurenine pathway in Alzheimer's disease, Parkinson's disease, and Huntington's disease: A systematic Review and meta-analysis.
Topics: 3-Hydroxyanthranilic Acid; Adenosine; Alzheimer Disease; Humans; Huntington Disease; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; NAD; Niacinamide; Parkinson Disease; Tryptophan | 2022 |
Importance of NAD+ Anabolism in Metabolic, Cardiovascular and Neurodegenerative Disorders.
Topics: Aging; Dietary Supplements; Humans; NAD; Neurodegenerative Diseases; Niacinamide; Nicotinamide Mononucleotide | 2023 |
[Research Progress in Niacinamide in the Prevention and Treatment of Mouth and Systemic Diseases].
Topics: Face; Humans; Mouth; NAD; Niacinamide; Skin | 2023 |
Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan.
Topics: Adolescent; Dietary Supplements; Humans; NAD; Niacinamide; Nicotinamide Mononucleotide; Nucleotides; Senotherapeutics; Sirtuin 1 | 2023 |
The use of Nicotinamide and Nicotinamide riboside as an adjunct therapy in the treatment of glaucoma.
Topics: Glaucoma; Humans; NAD; Niacinamide; Pyridinium Compounds | 2023 |
A Hitchhiker's Guide to Supplying Enzymatic Reducing Power into Synthetic Cells.
Topics: Artificial Cells; Coenzymes; NAD; NADP; Niacinamide; Oxidation-Reduction | 2023 |
NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health.
Topics: Diet; Humans; NAD; Niacinamide; Nicotinamide Mononucleotide | 2023 |
NAD+ Precursors and Intestinal Inflammation: Therapeutic Insights Involving Gut Microbiota.
Topics: Animals; Dysbiosis; Gastrointestinal Microbiome; Humans; Inflammation; Mammals; NAD; Niacinamide | 2023 |
Defining NAD(P)(H) Catabolism.
Topics: Biomarkers; Metabolome; NAD; Niacin; Niacinamide; Oxidation-Reduction | 2023 |
What is really known about the effects of nicotinamide riboside supplementation in humans.
Topics: Dietary Supplements; Humans; NAD; Niacinamide; Pyridinium Compounds | 2023 |
17 trial(s) available for nad and niacinamide
| Article | Year |
|---|---|
Nicotinic acid supplementation: effects on niacin status, cytogenetic damage, and poly(ADP-ribosylation) in lymphocytes of smokers.
Topics: Adult; DNA Damage; Humans; Lymphocytes; Male; NAD; Niacin; Niacinamide; Nutritional Status; Placebos; Poly Adenosine Diphosphate Ribose; Smoking | 1998 |
Nicotinamide suppresses hyperphosphatemia in hemodialysis patients.
Topics: Aged; Calcium; Female; Humans; Hyperparathyroidism, Secondary; Kidney Failure, Chronic; Male; Middle Aged; NAD; Niacinamide; Parathyroid Hormone; Phosphorus; Phosphorus Metabolism Disorders; Renal Dialysis | 2004 |
An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers.
Topics: Administration, Oral; Adult; Dietary Supplements; Female; Healthy Volunteers; Humans; Infant, Newborn; Male; Middle Aged; NAD; Niacinamide; Pyridinium Compounds; Young Adult | 2017 |
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD
Topics: Aged; Blood Pressure; Caloric Restriction; Double-Blind Method; Female; Humans; Male; Middle Aged; NAD; Niacinamide; Pyridinium Compounds; Vascular Stiffness | 2018 |
Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults.
Topics: Administration, Oral; Adult; Dietary Supplements; Double-Blind Method; Female; Healthy Volunteers; Humans; Male; Middle Aged; NAD; Niacinamide; Overweight; Provitamins; Pyridinium Compounds; Treatment Outcome | 2019 |
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD
Topics: Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents; Cross-Sectional Studies; Cytokines; Double-Blind Method; Humans; Male; Metabolome; Muscle, Skeletal; NAD; Niacinamide; Pyridinium Compounds; Transcriptome | 2019 |
Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin-resistant men.
Topics: Humans; Insulin Resistance; Male; Middle Aged; Mitochondria, Muscle; Muscle, Skeletal; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Obesity; Pyridinium Compounds | 2020 |
Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans.
Topics: Acetylcarnitine; Aged; Body Composition; Dietary Supplements; Female; Humans; Male; Middle Aged; Muscle, Skeletal; NAD; Niacinamide; Obesity; Overweight; Pyridinium Compounds | 2020 |
Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure.
Topics: Female; Heart Failure; Humans; Inflammation; Leukocytes, Mononuclear; Male; Mitochondria, Heart; Models, Cardiovascular; NAD; Niacinamide; Oxygen Consumption; Pyridinium Compounds | 2020 |
Nicotinamide riboside with pterostilbene (NRPT) increases NAD
Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Creatinine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; NAD; Niacinamide; Pilot Projects; Pyridinium Compounds; Stilbenes | 2020 |
NAD+-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults.
Topics: Aged; Dietary Supplements; Female; Humans; Male; Mitochondria; Muscle, Skeletal; NAD; Niacin; Niacinamide; Tryptophan | 2021 |
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease.
Topics: Dietary Supplements; Humans; NAD; Niacinamide; Parkinson Disease; Pyridinium Compounds | 2022 |
A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD
Topics: Adult; Humans; Metabolome; Middle Aged; NAD; Niacinamide; Pilot Projects; Ribose | 2022 |
Exercise training and NR supplementation to improve muscle mass and fitness in adolescent and young adult hematopoietic cell transplant survivors: a randomized controlled trial {1}.
Topics: Adolescent; Adult; Dietary Supplements; Exercise; Hematopoietic Stem Cell Transplantation; Humans; Muscle, Skeletal; NAD; Niacinamide; Pyridinium Compounds; Quality of Life; Sarcopenia; Survivors; Young Adult | 2022 |
Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators.
Topics: Acetylcysteine; Cysteine; Glutathione; Humans; Metabolomics; NAD; Niacinamide | 2023 |
The acute effect of different NAD
Topics: Humans; Metabolic Diseases; NAD; Neurodegenerative Diseases; Niacin; Niacinamide; Nicotinamide Mononucleotide | 2023 |
NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson's disease.
Topics: Double-Blind Method; Humans; NAD; Niacinamide; Parkinson Disease; Pyridinium Compounds | 2023 |
1176 other study(ies) available for nad and niacinamide
| Article | Year |
|---|---|
Inhibition of DNA synthesis in differentiating cardiac muscle by NAD.
Topics: Animals; Animals, Newborn; Biological Transport, Active; Cell Differentiation; DNA Replication; Female; Heart; Kinetics; Male; Myocardium; NAD; NADP; Niacinamide; Nicotinamide Mononucleotide; Pregnancy; Rats; Thymidine | 1976 |
Nuclear magnetic resonance studies on pyridine dinucleotides. 6. Dependence of the 13C spin--lattice relaxation time of 1-methylnicotinamide and nicotinamide adenine dinucleotide as a function of pD and phosphate concentration.
Topics: Chemical Phenomena; Chemistry; Electron Spin Resonance Spectroscopy; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; NAD; Niacinamide; Phosphates | 1976 |
The regulation of rat liver tryptophan pyrrolase activity by reduced nicotinamide-adenine dinucleotide (phosphate). Experiments with glucose and nicotinamide.
Topics: Animals; Diet; Fructose; Glucose; Kynurenine; Liver; Male; Methylphenazonium Methosulfate; NAD; NADP; Niacinamide; Rats; Sucrose; Time Factors; Tryptophan Oxygenase | 1976 |
Characterization of the NAD+ glycohydrolase associated with the rat liver nuclear envelope.
Topics: Animals; Hydrogen-Ion Concentration; Kinetics; Liver; Microsomes, Liver; N-Glycosyl Hydrolases; NAD; NAD+ Nucleosidase; Niacinamide; Phospholipids; Rats; Temperature | 1976 |
Effects of estradiol on the biosynthesis of pyridine nucleotide coenzymes in the rat uterus.
Topics: Animals; Castration; Estradiol; Female; NAD; NADP; Niacinamide; Nicotinic Acids; Rats; Uterus | 1976 |
Nicotinic acid and alcoholism [proceedings].
Topics: Alcohol Oxidoreductases; Animals; Ethanol; Fatty Acids; Fatty Liver; Humans; Hyperlipidemias; Liver; NAD; NADP; Niacinamide; Nicotinic Acids; Oxidation-Reduction; Rats | 1976 |
Effect of gangliosides and substrate analogues on the hydrolysis of nicotinamide adenine dinucleotide by choleragen.
Topics: Adenine; Adenine Nucleotides; Bacterial Toxins; Gangliosides; NAD; NAD+ Nucleosidase; NADP; Niacinamide; Nicotinamide Mononucleotide; Protein Conformation; Spectrometry, Fluorescence; Structure-Activity Relationship; Vibrio cholerae | 1977 |
[Nicotinamide coenzyme level in erythrocytes in children with cerebral paralysis].
Topics: Cerebral Palsy; Child; Child, Preschool; Coenzymes; Erythrocytes; Humans; Infant; NAD; NADP; Niacinamide | 1977 |
Metabolism of 6-aminonicotinic acid in Escherichia coli.
Topics: Escherichia coli; Mutation; NAD; NADP; Niacinamide; Nicotinic Acids | 1977 |
Developmental aspects of xenobiotic transformation.
Topics: Aminopyrine; Aniline Compounds; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Ethylmorphine; Female; Glucosephosphates; Hexobarbital; Hydrogen-Ion Concentration; Metyrapone; Microsomes, Liver; NAD; NADP; Niacinamide; Oxidoreductases, N-Demethylating; Oxidoreductases, O-Demethylating; Phenobarbital; Pregnancy; Rats; Semicarbazides | 1976 |
Acrylamide cytotoxicity in chick ganglia cultures.
Topics: Acrylamides; Animals; Cell Survival; Cells, Cultured; Chick Embryo; Ganglia, Spinal; Glutathione; NAD; NADP; Neuroglia; Neurons; Niacinamide | 1977 |
Nicotinamide adenine dinucleotide (NAD) stimulation of DNA synthesis by human bone marrow cells.
Topics: Adenosine; Bone Marrow; Cells, Cultured; Culture Media; DNA; Guanine Nucleotides; Humans; NAD; NADP; Niacinamide | 1978 |
Characterization of a long-wavelength feature in the absorption and circular dichroism spectra of beta-nicotinamide adenine dinucleotide. Evidence for a charge transfer transition.
Topics: Circular Dichroism; Molecular Conformation; NAD; NADP; Niacinamide; Nicotinamide Mononucleotide; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Temperature | 1978 |
Metabolism of niacin and niacinamide in perfused rat intestine.
Topics: Animals; Biological Transport; Injections; Intestinal Absorption; Intestine, Small; Male; NAD; NAD+ Nucleosidase; NADP; Niacinamide; Nicotinamide Mononucleotide; Nicotinic Acids; Perfusion; Rats; Ribonucleotides; Time Factors | 1979 |
Pyridine nucleotide synthesis in 3T3 cells.
Topics: Animals; Cell Division; Cell Line; Kinetics; Mice; Mice, Inbred BALB C; NAD; NADP; Niacinamide | 1979 |
Relationship between the ability of nicotinamide to maintain nicotinamide-adenine dinucleotide in rat liver cell culture and its effect on cytochrome P-450.
Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Liver; Male; NAD; NADP; Niacinamide; Rats | 1979 |
Isolation of a metabolite capable of differentially supporting the growth of nicotinamide adenine dinucleotide auxotrophs of Escherichia coli.
Topics: Aspartic Acid; Escherichia coli; Mutation; NAD; Niacinamide; Nicotinic Acids; Quinolinic Acids | 1975 |
Biochemical basis of liver necrosis caused by pyrrolizidine alkaloids and certain other hepatotoxins.
Topics: Alkylation; Animals; Chemical and Drug Induced Liver Injury; NAD; Necrosis; Niacinamide; Pyridones; Pyrrolizidine Alkaloids; Rats; Streptozocin | 1975 |
Stimulation of nuclear poly (adenosine diphosphate-ribose) polymerase activity from HeLa cells by endonucleases.
Topics: Cell Nucleus; Deoxyribonucleases; DNA Repair; Endonucleases; HeLa Cells; Micrococcal Nuclease; N-Glycosyl Hydrolases; NAD; NAD+ Nucleosidase; Niacinamide; Nucleoside Diphosphate Sugars; Phosphoric Diester Hydrolases; Poly Adenosine Diphosphate Ribose; Pronase; Ribonucleases; Snake Venoms; Thymidine; Tritium | 1975 |
Correlation between DNA synthesis and intracellular NAD in cultured human leukemic lymphocytes.
Topics: Cells, Cultured; Culture Media; DNA; Humans; Leukemia, Monocytic, Acute; Lymphocytes; Methylnitrosourea; NAD; Niacinamide; Thymidine | 1975 |
Pancreatic islet-cell and other tumors in rats given heliotrine, a monoester pyrrolizidine alkaloid, and nicotinamide.
Topics: Adenoma; Adenoma, Islet Cell; Animals; Carcinoma, Hepatocellular; Hyperplasia; Liver Neoplasms; Male; NAD; Neoplasms, Experimental; Niacinamide; Papilloma; Pituitary Neoplasms; Pyrrolizidine Alkaloids; Rats; Urinary Bladder Neoplasms | 1975 |
[Studies on the mechanism of the diabetogenic activity of streptozotocin and on the ability of compounds to block the diabetogenic activity of streptozotocin (author's transl)].
Topics: Adenoma, Islet Cell; Amides; Animals; Blood Glucose; Cats; Cystine; Deoxyglucose; Diabetes Mellitus; Dimethylnitrosamine; Fatty Acids, Nonesterified; Glutathione; Guinea Pigs; Insulin; Islets of Langerhans; Male; Mannoheptulose; Mice; NAD; Niacinamide; Nicotinic Acids; Pancreatic Neoplasms; Picolinic Acids; Pyrazinamide; Rabbits; Rats; Streptozocin; Tolbutamide; Uric Acid | 1975 |
Nicotinamide adenine dinucleotide levels in chick limb mesodermal cells in vitro: effects of 3-acetylpyridine and nicotinamide.
Topics: Animals; Cells, Cultured; Chick Embryo; DNA; Mesoderm; NAD; Niacinamide; Pyridines | 1975 |
Autoradiographic studies of nicotinic acid utilization in human-mouse heterokaryons and inhibition of utilization in newly-formed hybrid cells.
Topics: Aminopterin; Cell Division; Cell Fusion; Culture Media; DNA; Hybrid Cells; NAD; Niacinamide; Nicotinic Acids | 1975 |
Pyridine nucleotide metabolism in mitotic cells.
Topics: Cell Line; Colchicine; Kinetics; Mitosis; NAD; Niacinamide; Nicotinamide Mononucleotide; Nicotinic Acids | 1975 |
ADP-ribosylation of DNA-dependent RNA polymerase of Escherichia coli by an NAD+: protein ADP-ribosyltransferase from bacteriophage T4.
Topics: Bacterial Proteins; Coliphages; DNA-Directed RNA Polymerases; Escherichia coli; Kinetics; Muramidase; Mutation; NAD; Niacinamide; Osmolar Concentration; Pentosyltransferases; Viral Proteins | 1975 |
Nicotinamide adenine dinucleotide degradation in infarcted cardiac muscle.
Topics: Animals; Dogs; Myocardial Infarction; Myocardium; NAD; NAD+ Nucleosidase; Niacinamide; Subcellular Fractions | 1975 |
Interaction of Vibrio cholerae toxin with sarcoma 180 cell membranes.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Dithiothreitol; Enterotoxins; Enzyme Activation; Female; Glutathione; In Vitro Techniques; Isoproterenol; Magnesium; Mice; NAD; Niacinamide; Sarcoma 180; Vibrio cholerae | 1976 |
Ascorbate inhibition of 6-aminonicotinamide teratogenesis in chicken embryos.
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Animals; Body Weight; Cartilage; Chick Embryo; Fetus; Gestational Age; Limb Deformities, Congenital; NAD; Niacinamide; Oxidative Phosphorylation; Time Factors | 1976 |
NAD precursors as antiteratogens against aminothiadiazole.
Topics: Animals; Dose-Response Relationship, Drug; Female; Fetal Resorption; Gestational Age; Kynurenine; Male; NAD; Niacinamide; Nicotinic Acids; Pregnancy; Quinolinic Acids; Rats; Teratogens; Thiadiazoles; Tryptophan | 1976 |
Letter: Intramolecular charge-transfer interaction between the oxidized and reduced forms of nicotinamide in a polymeric system. NAD coenzyme model.
Topics: Energy Transfer; NAD; Niacinamide; Oxidation-Reduction; Polyvinyls | 1976 |
Biological probes. 3. Methods for carbon-4 and carbon-5 labeling in nicotinamide.
Topics: Carbon Isotopes; Isotope Labeling; NAD; Niacinamide | 1976 |
Failure of nicotinamide in the treatment of hemorrhagic shock.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Kidney; Liver; NAD; Niacinamide; Nicotinic Acids; Oxidative Phosphorylation; Rats; Shock, Hemorrhagic | 1976 |
Poly(adenosine diphosphate ribose) polymerase activity and nicotinamide adenine dinucleotide in differentiating cardiac muscle.
Topics: Adenosine Triphosphate; Animals; Bucladesine; Caffeine; Cell Differentiation; Cell Nucleus; Dactinomycin; DNA; DNA Nucleotidyltransferases; Heart; Isoproterenol; Myocardium; N-Glycosyl Hydrolases; NAD; NAD+ Nucleosidase; Niacinamide; Proteins; Rats; Theophylline; Thymidine; Xanthines | 1976 |
[Metabolism of nicotinic acid in plant cell suspension cultures, III: Formation and metabolism of trigonelline (author's transl)].
Topics: Alkaloids; Cells, Cultured; NAD; Niacinamide; Nicotinic Acids; Plants | 1976 |
[Metabolism of nicotinic acid in plant cell suspension cultures, IV: Occurrence and metabolism of nicotinic acid N-alpha-arabinoside (author's transl)].
Topics: Arabinose; Carbon Dioxide; Cells, Cultured; Kinetics; NAD; Niacinamide; Nicotinic Acids; Nucleosides; Plants | 1976 |
NAD glycohydrolase activity in hearts with acute experimental infarction.
Topics: Animals; Disease Models, Animal; Dogs; Myocardial Infarction; Myocardium; NAD; NAD+ Nucleosidase; Niacinamide | 1976 |
Mechanism of action of 2-amino-1,3,4-thiadiazole (NSC 4728).
Topics: Animals; Binding, Competitive; IMP Dehydrogenase; In Vitro Techniques; Inosine Nucleotides; Ketone Oxidoreductases; Leukemia L1210; Mice; NAD; Niacinamide; Thiadiazoles | 1977 |
The action of streptozotocin in mouse leukaemia cells.
Topics: Animals; Cell Line; Kinetics; Leukemia, Experimental; Mice; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Streptozocin; Theophylline | 1976 |
Control of histone H1 dimer-poly(ADP-ribose) complex formation by poly(ADP-ribose) glycohydrolase.
Topics: Animals; Breast Neoplasms; Cell Line; Cell Nucleus; Female; Glycoside Hydrolases; Histones; Humans; Lactation; Mammary Glands, Animal; Mammary Neoplasms, Experimental; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Pregnancy; Rats | 1977 |
Synthesis of pyridine nucleotides by mitochondrial fractions of yeast.
Topics: Adenosine Triphosphate; Magnesium; Mitochondria; NAD; Niacinamide; Nicotinamide Mononucleotide; Nicotinic Acids; Phosphoribosyl Pyrophosphate; Saccharomyces cerevisiae; Sonication | 1976 |
Model dehydrogenase reactions. Catalysis of dihydronicotinamide reductions by noncovalent interactions.
Topics: Acridines; Catalysis; Chemical Phenomena; Chemistry; Chloranil; Kinetics; NAD; Niacinamide; Oxidation-Reduction | 1977 |
The mechanism of ADP-ribosylation of elongation factor 2 catalyzed by fragment A from diphtheria toxin.
Topics: Adenine; Adenosine Diphosphate Sugars; Animals; Binding Sites; Chromatography, Affinity; Chromatography, Gel; Diphtheria Toxin; Kinetics; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Peptide Elongation Factors; Peptide Fragments; Rabbits; Reticulocytes; Ribose | 1977 |
Control of growth by picolinic acid: differential response of normal and transformed cells.
Topics: Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Chelating Agents; Depression, Chemical; Dose-Response Relationship, Drug; Moloney murine leukemia virus; NAD; Niacinamide; Nicotinic Acids; Picolinic Acids; Sarcoma Viruses, Murine; Structure-Activity Relationship; Time Factors | 1977 |
Reduction of streptozotocin toxicity by 3-O-methyl-D-glucose with enhancement of antitumor activity in murine L1210 leukemia.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Interactions; Drug Therapy, Combination; Leukemia L1210; Liver; Male; Methylglucosides; Methylglycosides; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; NAD; Niacinamide; Streptozocin | 1977 |
Poly(adenosine diphosphate ribose) polymerase and deoxyribonucleic acid damage [proceedings].
Topics: Animals; Cells, Cultured; DNA; Leukemia L1210; NAD; NAD+ Nucleosidase; Niacinamide; Poly(ADP-ribose) Polymerases; Zinostatin | 1977 |
Metabolic effects and liver damage after prolonged administration of high doses of nicotinamide to rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Injections, Intraperitoneal; Liver; Male; NAD; Niacinamide; Rats; Time Factors | 1977 |
Models for NADH coenzymes. Isotope effects in the N-benzyldihydronicotinamide/N-benzylnicotinamide salt transhydrogenation reaction.
Topics: Chemical Phenomena; Chemistry; Coenzymes; Hydrogenation; NAD; Niacinamide | 1977 |
The contribution of tryptophan to the regulation of the NAD+ level in mouse liver.
Topics: Aging; Animals; Liver; Mice; NAD; Niacinamide; Nicotinic Acids; Organ Specificity; Tryptophan | 1975 |
Suppression and stimulation of DNA synthesis by ADP-ribosylation of nuclear proteins from adult hen and chick embryo liver.
Topics: Aging; Animals; Cell Nucleus; Chick Embryo; Chickens; DNA; Female; Liver; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose; Proteins; Templates, Genetic | 1978 |
[Indices of nicotinic acid metabolism and bioenergy processes in osteoarthrosis deformans].
Topics: Adenosine Triphosphate; Adult; Aged; Energy Metabolism; Female; Humans; Male; Middle Aged; NAD; Niacinamide; Nicotinic Acids; Osteoarthritis | 1978 |
Isolation of an avian erythrocyte protein possessing ADP-ribosyltransferase activity and capable of activating adenylate cyclase.
Topics: Adenosine Diphosphate Sugars; Adenylyl Cyclases; Animals; Brain; Cholera Toxin; Chromatography, Thin Layer; Enzyme Activation; Erythrocytes; Muramidase; NAD; Niacinamide; Nucleotidyltransferases; Phosphoric Diester Hydrolases; Ribose; Snake Venoms; Turkeys | 1978 |
[Polypeptide synthetase activity of chromatin from eukaryotic cells].
Topics: Aminoacylation; Animals; Asparagine; Chromatin; Glutamates; Glutamine; Glycine; Hepatectomy; Liver; Male; NAD; Niacinamide; Peptide Biosynthesis; Poly Adenosine Diphosphate Ribose; Rats; Thymidine | 1978 |
[Nicotinic acid balance in diabetes mellitus].
Topics: Adolescent; Adult; Aged; Chronic Disease; Diabetes Mellitus; Female; Humans; Male; Middle Aged; NAD; Niacinamide; Nicotinic Acids | 1978 |
The effect of gamma radiation and neocarzinostatin on NAD and ATP levels in mouse leukaemia cells.
Topics: Adenosine Triphosphate; Animals; Antibiotics, Antineoplastic; Dose-Response Relationship, Drug; Gamma Rays; Glycolysis; Leukemia L1210; NAD; Niacinamide; Thymidine; Zinostatin | 1978 |
Pyridine nucleotide cycle of Salmonella typhimurium: isolation and characterization of pncA, pncB, and pncC mutants and utilization of exogenous nicotinamide adenine dinucleotide.
Topics: Amidohydrolases; Chromosome Mapping; Drug Resistance, Microbial; Genes; Genetic Linkage; Mutation; NAD; Niacinamide; Nicotinamidase; Nicotinic Acids; Pentosyltransferases; Salmonella typhimurium | 1979 |
Effect of NAD, nicotinamide and nicotinic acid on cyclic AMP accumulation by fat cells.
Topics: Adenylyl Cyclases; Adipose Tissue; Animals; Cyclic AMP; Female; NAD; Niacinamide; Nicotinic Acids; Rats | 1979 |
Pyridine nucleotide cycle of Salmonella typhimurium: regulation of nicotinic acid phosphoribosyltransferase and nicotinamide deamidase.
Topics: Amidohydrolases; Enzyme Repression; Mutation; NAD; Niacinamide; Nicotinamidase; Nicotinamide Mononucleotide; Nicotinic Acids; Pentosyltransferases; Salmonella typhimurium | 1979 |
Nicotinamide adenine dinucleotide metabolism in Candida albicans.
Topics: Biological Transport; Candida albicans; Kinetics; NAD; Niacinamide; Nicotinic Acids; Tryptophan | 1979 |
NAD glycohydrolase and ADP-ribosyltransferase activities are intrinsic to the A1 peptide of choleragen.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Animals; Cell Membrane; Cholera Toxin; Enzyme Activation; Liver; NAD; NAD+ Nucleosidase; Niacinamide; Nucleotidyltransferases; Rats | 1979 |
Characterisation of poly(ADP-Rib) polymerase activity in nuclei from the slime mould Dictyostelium discoideum.
Topics: Cell Nucleus; Dictyostelium; Kinetics; Magnesium; NAD; NAD+ Nucleosidase; Niacinamide; Nucleoproteins; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases | 1979 |
Demonstration of in vitro covalent modification of chromosomal proteins by poly(ADP) ribosylation in plant nuclei.
Topics: Cell Nucleus; Chromosomes; Deoxyribonucleases; Histones; Kinetics; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Plants; Poly Adenosine Diphosphate Ribose; Ribonucleases | 1979 |
Induction of erythroid differentiation of murine erythroleukemia cells by nicotinamide and related compounds.
Topics: Animals; Cell Differentiation; Cell Line; Erythropoiesis; Friend murine leukemia virus; Globins; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; NAD; Niacinamide; Poly(ADP-ribose) Polymerases; RNA, Messenger | 1979 |
Flavin-nicotinamide biscoenzymes: models for the interaction between NADH (NADPH) and flavin in flavoenzymes. Reaction rates and physicochemical properties of intermediate species.
Topics: Binding Sites; Enzymes; Flavins; Flavoproteins; Hydrogen-Ion Concentration; Kinetics; Molecular Conformation; NAD; Niacinamide; Oxidation-Reduction; Spectrophotometry; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1975 |
Nicotinamide-adenine dinucleotide inhibition of pig kidney alkaline phosphatase.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Alkaline Phosphatase; Animals; Binding Sites; Hydrogen-Ion Concentration; Kidney; Kinetics; Magnesium; NAD; Niacinamide; Protein Binding; Swine; Temperature; Tetranitromethane; Thermodynamics | 1975 |
Properties of aryl hydrocarbon (benzo[a]pyrene) hydroxylase in the liver from C3H/He and DBA/2 strains of mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Cyclohexanes; Cyclohexenes; Enzyme Induction; Epoxide Hydrolases; Epoxy Compounds; Female; Flavonoids; Hydrocarbons, Chlorinated; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; NAD; Niacinamide; Sex Factors; Species Specificity | 1975 |
Poly(adenosine diphosphate ribose) polymerase in Physarum polycephalum.
Topics: Cell Nucleus; Dithiothreitol; DNA; Hydrogen-Ion Concentration; Kinetics; Magnesium; Mercaptoethanol; Mitosis; Myxomycetes; N-Glycosyl Hydrolases; NAD; NAD+ Nucleosidase; Niacinamide; Physarum; Stimulation, Chemical; Temperature | 1975 |
Pyridine nucleosidase in bull semen. II. Biochemical properties.
Topics: Animals; Cattle; Hot Temperature; Hydrolysis; Kinetics; Male; N-Glycosyl Hydrolases; NAD; NAD+ Nucleosidase; NADP; Niacinamide; Semen; Time Factors | 1975 |
Aryl hydrocarbon hydroxylase in liver nuclei of C3H/He and DBA/2 mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Cell Nucleus; Cyclohexanes; Endoplasmic Reticulum; Epoxide Hydrolases; Female; Flavonoids; Glucose-6-Phosphatase; Liver; Methylcholanthrene; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Microsomes, Liver; NAD; NADP; Niacinamide; Nucleotidases; Phenobarbital; Propane | 1975 |
Effect of tolbutamide on aminophylline-, 3,5-AMP-dibutyrate- or glucagon-induced insulin release from pancreatic islets after impairment of pyridine nucleotide metabolism caused by 6-aminonicotinamide (6-AN).
Topics: 6-Aminonicotinamide; Aminophylline; Animals; Bucladesine; Female; Glucagon; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; NAD; NADP; Niacinamide; Rats; Tolbutamide | 1975 |
Gs alpha is a substrate for mono(ADP-ribosyl)transferase of NG108-15 cells. ADP-ribosylation regulates Gs alpha activity and abundance.
Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; Blotting, Western; Cholera Toxin; Glioma; GTP-Binding Proteins; Hybrid Cells; Iloprost; Immunosorbent Techniques; NAD; Neuroblastoma; Niacinamide; Substrate Specificity; Tumor Cells, Cultured | 1992 |
[An analysis of the connection between the inhibition of NAD biosynthesis and the antitumor activity of drugs].
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Screening Assays, Antitumor; Female; Mice; Mice, Inbred Strains; NAD; Neoplasm Transplantation; Niacin; Niacinamide; Time Factors | 1992 |
Changes in pyridine and adenine nucleotide levels in Friend erythroleukaemia cells during growth and differentiation.
Topics: Acetamides; Adenine Nucleotides; Adenosine Triphosphate; Animals; Cell Differentiation; Cell Division; Friend murine leukemia virus; Hematinics; Leukemia, Erythroblastic, Acute; Mice; NAD; NADP; Niacinamide; Nicotinamide-Nucleotide Adenylyltransferase; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Poly(ADP-ribose) Polymerases; Tumor Cells, Cultured | 1992 |
Impairment of lymphocyte adhesion to cultured fibroblasts and endothelial cells by gamma-irradiation.
Topics: Adenosine Triphosphate; Benzamides; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Endothelium, Vascular; Fibroblasts; Gamma Rays; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1; Interferon-gamma; Interleukin-1; Lymphocyte Function-Associated Antigen-1; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Recombinant Proteins; T-Lymphocytes | 1992 |
Metabolism of NAD(P)H by blood components. Relevance to bioreductively activated prodrugs in a targeted enzyme therapy system.
Topics: Animals; Antineoplastic Agents; Aziridines; Biotransformation; Blood; Blood Coagulation; Cattle; Dihydrolipoamide Dehydrogenase; Horses; Humans; Hydrolysis; Lactates; NAD; NADP; Niacinamide; Oxidation-Reduction; Prodrugs; Tumor Cells, Cultured | 1992 |
The thyroid hormone response element is required for activation of the growth hormone gene promoter by nicotinamide analogs.
Topics: Adenosine Diphosphate Ribose; Animals; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Growth Hormone; NAD; Niacinamide; Promoter Regions, Genetic; Rats; Receptors, Thyroid Hormone; Recombinant Proteins; Transcription, Genetic; Transfection; Triiodothyronine | 1992 |
Sulfur mustard-induced microvesication in hairless guinea pigs: effect of short-term niacinamide administration.
Topics: Animals; Blister; Enzyme Activation; Erythema; Guinea Pigs; Male; Mustard Gas; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Skin; Time Factors | 1992 |
Potentiation of CB 1954 cytotoxicity by reduced pyridine nucleotides in human tumour cells by stimulation of DT diaphorase activity.
Topics: Antineoplastic Agents; Aziridines; DNA, Neoplasm; Drug Synergism; Humans; Intracellular Fluid; Kinetics; NAD; NAD(P)H Dehydrogenase (Quinone); Niacinamide; Pyridinium Compounds; Ribonucleosides; Stimulation, Chemical; Tumor Cells, Cultured | 1992 |
Cell proliferation and cell death in immunosenescence.
Topics: Adenosine Triphosphate; Adult; Age Factors; Carnitine; Cell Death; Cell Division; Cellular Senescence; Child; DNA Damage; DNA Repair; Down Syndrome; Free Radicals; Humans; Leukocytes, Mononuclear; Microscopy, Electron, Scanning; NAD; Niacinamide; Oxidation-Reduction; Reactive Oxygen Species | 1992 |
Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase.
Topics: Acetophenones; ADP Ribose Transferases; Animals; Benzamides; Cattle; Enzyme Inhibitors; Fatty Acids, Nonesterified; Isoquinolines; Kinetics; NAD; Naphthalenes; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Pyrimidines; Quinazolines; Quinolines; Structure-Activity Relationship; Thymus Gland | 1992 |
The rapid response of isolated mitochondrial particles to 0.1 nM-tri-iodothyronine correlates with the ADP-ribosylation of a single inner-membrane protein.
Topics: Adenosine Diphosphate; Adenosine Diphosphate Ribose; Animals; Chemical Precipitation; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Hypothyroidism; Kinetics; Male; Membrane Proteins; Mitochondria, Liver; NAD; Niacinamide; Oxygen Consumption; Propylthiouracil; Rats; Rats, Inbred Strains; Triiodothyronine | 1992 |
Influence of ADP-ribosyltransferase inhibitors on the intracellular NAD and ATP levels in Ehrlich ascites tumor cells: implication for the altered NAD + ATP-dependent cellular sensitivity to the cytotoxic agents.
Topics: Adenosine Triphosphate; Animals; Azacitidine; Benzamides; Carcinoma, Ehrlich Tumor; Female; Mice; Microsomes; NAD; NAD+ Nucleosidase; Niacinamide; Nicotinamide-Nucleotide Adenylyltransferase; Poly(ADP-ribose) Polymerase Inhibitors; Tumor Cells, Cultured | 1990 |
Multiple cell cycles occur in rat hepatocytes cultured in the presence of nicotinamide and epidermal growth factor.
Topics: Animals; Cell Cycle; Cells, Cultured; DNA; Epidermal Growth Factor; Liver; Male; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Inbred Strains; Sister Chromatid Exchange | 1991 |
Effects of nicotinamide on biochemical changes and microblistering induced by sulfur mustard in human skin organ cultures.
Topics: Culture Media; Glucose; Humans; Immunohistochemistry; Mustard Gas; NAD; Niacinamide; Organ Culture Techniques; Skin; Time Factors | 1991 |
Pyridine nucleotide levels under conditions of 5 alpha-dihydrotestosterone-stimulated 17 beta-estradiol formation from estrone and pathway of nicotinamide adenine dinucleotide biosynthesis in placental villi in vitro.
Topics: Chorionic Villi; Dihydrotestosterone; Estradiol; Estrone; Female; Humans; Kinetics; NAD; NADP; Niacin; Niacinamide; Oxidation-Reduction; Pregnancy | 1991 |
ADP-ribosyl cyclase: an enzyme that cyclizes NAD+ into a calcium-mobilizing metabolite.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Aplysia; Calcium; Chromatography, High Pressure Liquid; Cyclic ADP-Ribose; Electrophoresis, Polyacrylamide Gel; Kinetics; Magnetic Resonance Spectroscopy; N-Glycosyl Hydrolases; NAD; Niacinamide; Second Messenger Systems | 1991 |
Requirement of ADP-ribosylation for the pertussis toxin-induced alteration in electrophoretic mobility of G-proteins.
Topics: Adenosine Diphosphate Ribose; Animals; Autoradiography; Cell Line; Electrophoresis, Polyacrylamide Gel; Glioma; GTP-Binding Proteins; Hybrid Cells; Immunoblotting; Kinetics; Macromolecular Substances; NAD; Neuroblastoma; Niacinamide; Pertussis Toxin; Phosphorus Radioisotopes; Virulence Factors, Bordetella | 1991 |
Inhibition by cyclosporine A of the prooxidant-induced but not of the sodium-induced calcium release from rat kidney mitochondria.
Topics: Adenosine Diphosphate Ribose; Alloxan; Animals; Calcium; Cyclosporine; Female; Glutathione; Glutathione Disulfide; Hydrolysis; Kidney; Mitochondria; Mitochondria, Liver; NAD; Niacinamide; Oxidants; Peroxides; Rats; Rats, Inbred Strains; Sodium; tert-Butylhydroperoxide | 1991 |
Niacinamide pretreatment reduces microvesicle formation in hairless guinea pigs cutaneously exposed to sulfur mustard.
Topics: Animals; Biopsy; Edema; Erythema; Guinea Pigs; Male; Mustard Gas; NAD; Niacinamide; Skin | 1991 |
Thiol redox and phosphate transport in renal brush-border membrane. Effect of nicotinamide.
Topics: Animals; Biological Transport; Dithiothreitol; Glucose; Glutathione; In Vitro Techniques; Kidney; Male; Microvilli; NAD; Niacinamide; Oxidation-Reduction; Phosphates; Rabbits; Sulfhydryl Compounds | 1990 |
Inhibition of pro-oxidant-induced mitochondrial pyridine nucleotide hydrolysis and calcium release by 4-hydroxynonenal.
Topics: Adenosine Diphosphate Ribose; Aldehydes; Alloxan; Animals; Calcium; Female; Hydrolysis; Intracellular Fluid; Mitochondria, Liver; NAD; Niacinamide; Rats; Rats, Inbred Strains | 1990 |
In vitro evaluation of nicotinamide riboside analogs against Haemophilus influenzae.
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Escherichia coli; Haemophilus Infections; Haemophilus influenzae; Magnetic Resonance Spectroscopy; NAD; Niacinamide; Pyridinium Compounds | 1990 |
Importance of nicotinamide as an NAD precursor in the human erythrocyte.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adult; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Inosine Monophosphate; Models, Biological; NAD; Niacin; Niacinamide; Reference Values | 1990 |
The use of human epidermal keratinocytes in culture as a model for studying the biochemical mechanisms of sulfur mustard toxicity.
Topics: Cell Survival; Cells, Cultured; Humans; Keratinocytes; Models, Biological; Mustard Gas; NAD; Niacinamide | 1990 |
Nicotinamide uptake and metabolism in the procyclic form of Trypanosoma brucei.
Topics: Animals; Biological Transport; NAD; Niacinamide; Trypanosoma brucei brucei | 1990 |
Regulation of nicotinamide-adenine dinucleotide synthesis in erythrocytes of patients with hypoxanthine-guanine phosphoribosyltransferase deficiency and a patient with phosphoribosylpyrophosphate synthetase superactivity.
Topics: Adult; Cells, Cultured; Child; Chromatography, High Pressure Liquid; Erythrocytes; Female; Humans; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Male; Metabolism, Inborn Errors; NAD; Niacinamide; Nicotinic Acids; Phosphotransferases; Ribose-Phosphate Pyrophosphokinase | 1990 |
Mechanisms of endothelial cell ATP depletion after oxidant injury.
Topics: Adenosine Triphosphate; Benzamides; Cells, Cultured; DNA Damage; Endothelium, Vascular; Enzyme Activation; Glucose Oxidase; Humans; NAD; Niacinamide; Oxidation-Reduction; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Umbilical Veins; Xanthine Oxidase | 1989 |
Nicotinamide prolongs survival of primary cultured hepatocytes without involving loss of hepatocyte-specific functions.
Topics: Albumins; Amino Acid Oxidoreductases; Animals; Cell Count; Cell Survival; Cells, Cultured; DNA; Humans; L-Amino Acid Oxidase; Liver; NAD; Niacinamide; Rats; RNA, Messenger | 1989 |
On the cytotoxicity of chrysotile asbestos fibers toward pulmonary alveolar macrophages. II. Effects of nicotinamide on the cell metabolism.
Topics: Animals; Asbestos; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Galactosidases; L-Lactate Dehydrogenase; Lactates; Macrophages; Male; NAD; NADP; Niacinamide; Nucleotides; Phosphorylation; Pulmonary Alveoli; Pyruvates; Rats | 1989 |
NAD+ levels and glucose uptake of cultured human epidermal cells exposed to sulfur mustard.
Topics: Adult; Cells, Cultured; Epidermis; Glucose; Humans; Mustard Compounds; Mustard Gas; NAD; Niacin; Niacinamide; Skin | 1989 |
Pertussis toxin induces structural changes in G alpha proteins independently of ADP-ribosylation.
Topics: Adenine Nucleotides; Adenosine Diphosphate Ribose; Animals; Blotting, Western; Brain; Cattle; Electrophoresis, Polyacrylamide Gel; GTP-Binding Proteins; In Vitro Techniques; Membrane Proteins; NAD; Niacinamide; Pentosyltransferases; Pertussis Toxin; Virulence Factors, Bordetella | 1989 |
Differentiation of 3T3-L1 pre-adipocytes induced by inhibitors of poly(ADP-ribose) polymerase and by related noninhibitory acids.
Topics: Adenosine Diphosphate Ribose; Adipose Tissue; ADP Ribose Transferases; Animals; Benzamides; Benzoates; Benzoic Acid; Cell Differentiation; Cell Line; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation; Glycerolphosphate Dehydrogenase; High Mobility Group Proteins; Insulin; Mice; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases | 1989 |
[NAD participation in protecting DNA from damaging factors].
Topics: Animals; Cell Nucleus; Chickens; Chromatin; DNA Damage; Ethidium; Liver; NAD; Niacinamide | 1989 |
Isotope effects on binding of NAD+ to lactate dehydrogenase.
Topics: Animals; Binding Sites; Deuterium; In Vitro Techniques; L-Lactate Dehydrogenase; Mass Spectrometry; Molecular Structure; NAD; Niacinamide; Scintillation Counting; Tritium | 1989 |
Histidine 21 is at the NAD+ binding site of diphtheria toxin.
Topics: Adenine; Adenosine; Binding Sites; Diethyl Pyrocarbonate; Diphtheria Toxin; Formates; Histidine; Kinetics; NAD; Niacinamide; Peptide Fragments | 1989 |
Effects of a dietary excess of leucine and of the addition of leucine and 2-oxo-isocaproate on the metabolism of tryptophan and niacin in isolated rat liver cells.
Topics: Animals; Caproates; In Vitro Techniques; Keto Acids; Kynurenine; Leucine; Liver; Male; NAD; Niacin; Niacinamide; Rats; Rats, Inbred Strains; Tryptophan; Xanthurenates | 1989 |
Specific inhibition of rat renal Na+/phosphate cotransport by picolinamide.
Topics: Amides; Animals; Biological Transport; Kidney Cortex; Male; NAD; Niacinamide; Phosphates; Picolinic Acids; Rats; Rats, Inbred Strains; Sodium | 1989 |
[Formation of taurine and amino acid pools in rat tissues upon stimulation of NAD synthesis].
Topics: Amino Acids; Animals; Brain; Cysteine Dioxygenase; Dioxygenases; Enzyme Induction; Male; Mitochondria, Liver; Myocardium; NAD; Niacinamide; Oxygenases; Rats; Taurine | 1989 |
Hepatic poly(ADP ribose) polymerase activity in methyl donor-deficient rats.
Topics: Animals; Choline Deficiency; Diet; DNA Damage; DNA Repair; Lipid Metabolism; Liver; Male; Malondialdehyde; Methionine; NAD; Niacinamide; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred Strains | 1989 |
Inability of poly-ADP-ribosylation inhibitors to protect peripheral blood lymphocytes from the toxic effects of ADA inhibition.
Topics: Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Benzamides; Colony-Forming Units Assay; Deoxyadenosines; DNA Damage; Humans; Lymphocyte Activation; Lymphocytes; NAD; Niacinamide; Nucleoside Deaminases; Pentostatin; Poly(ADP-ribose) Polymerase Inhibitors | 1989 |
High dose nicotinamide fails to prevent diabetes in BB rats.
Topics: Age Factors; Animals; Autoimmune Diseases; Blood Glucose; Cyclosporine; Deferoxamine; Diabetes Mellitus, Experimental; DNA Damage; Drug Evaluation, Preclinical; Hyperplasia; Insulin; Insulin Secretion; Islets of Langerhans; Models, Biological; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Inbred BB | 1989 |
Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo.
Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; Animals; Benzamides; Bromodeoxyuridine; Cattle; NAD; NAD+ Nucleosidase; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors | 1989 |
Phosphorylation of 3-deazaguanosine by nicotinamide riboside kinase in Chinese hamster ovary cells.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Guanosine; NAD; Niacinamide; Phosphorylation; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds; Substrate Specificity | 1989 |
NAD synthesis by erythrocytes in phosphoribosylpyrophosphate synthetase (PRPPs) superactivity.
Topics: Child; Erythrocytes; Female; Glutamine; Humans; Male; NAD; Niacin; Niacinamide; Phosphotransferases; Purine-Pyrimidine Metabolism, Inborn Errors; Ribose-Phosphate Pyrophosphokinase | 1989 |
Is the NAD-poly (ADP-ribose) polymerase system the trigger in radiation-induced death of mouse thymocytes?
Topics: Animals; Benzamidines; Cell Survival; Chromatin; DNA; DNA Damage; Gamma Rays; Male; Mice; NAD; NAD+ Nucleosidase; Niacinamide; Poly(ADP-ribose) Polymerases; T-Lymphocytes | 1989 |
Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes.
Topics: Adenosine Triphosphate; Cell Survival; Cladribine; Coformycin; Deoxyadenosines; DNA; Humans; In Vitro Techniques; Lymphocytes; NAD; Niacinamide; Pentostatin; RNA | 1985 |
Nicotinamide and the regulation of renal phosphate transport.
Topics: Absorption; Animals; Biological Transport; Cell Line; Cyclic AMP; Cycloheximide; Kidney; Kidney Tubules, Proximal; Male; Microvilli; NAD; Niacinamide; Phosphates; Rats; Rats, Inbred Strains; Sodium; Swine | 1988 |
The cytotoxicity of chrysotile asbestos fibers to pulmonary alveolar macrophages. I. Effects of inhibitors of ADP-ribosyl transferase.
Topics: Animals; Asbestos; Asbestos, Serpentine; Benzamides; beta-Galactosidase; Cell Survival; Cells, Cultured; L-Lactate Dehydrogenase; Macrophages; Male; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Pulmonary Alveoli; Rats; Rats, Inbred Strains | 1988 |
Influence of ethanol upon the introduction of tyrosine aminotransferase in liver, upon the NAD content in liver and brain, and upon the activity of glutamate oxalate aminotransferase and glutamate pyruvate aminotransferase in the serum of rats.
Topics: Adrenalectomy; Alanine Transaminase; Animals; Aspartate Aminotransferases; Brain Chemistry; Ethanol; Liver; Methionine; NAD; Niacinamide; Rats; Rats, Inbred Strains; Tryptophan; Tyrosine Transaminase | 1985 |
NAD metabolism and induction of tyrosine aminotransferase in the rat.
Topics: Adrenalectomy; Animals; Brain; Enzyme Induction; Kidney; Liver; Male; NAD; Niacinamide; Organ Specificity; Oxidation-Reduction; Prednisolone; Rats; Rats, Inbred Strains; Spleen; Theophylline; Tyrosine Transaminase | 1985 |
Influence of ethanol, nicotinamide, orotic acid and caffeine upon the induction of tyrosine aminotransferase, the NAD content and the ADPR transferase activity in rat liver.
Topics: Adrenalectomy; Animals; Caffeine; Enzyme Induction; Ethanol; Liver; NAD; Niacinamide; Nucleotidyltransferases; Orotic Acid; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred Strains; Tyrosine Transaminase | 1986 |
Activation of guanylate cyclase by E. coli heat-stable enterotoxin (STa). Modulation by NAD and pertussis toxin.
Topics: Adenylate Cyclase Toxin; Animals; Bacterial Toxins; Enterotoxins; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Female; Guanylate Cyclase; Intestinal Mucosa; NAD; Niacinamide; Pertussis Toxin; Rats; Virulence Factors, Bordetella | 1986 |
Biochemical basis for deoxyadenosine and 2-chlorodeoxyadenosine toxicity to resting human lymphocytes.
Topics: Adenosine Triphosphate; Cladribine; Deoxyadenosines; DNA; DNA Repair; Humans; Lymphocytes; NAD; Niacinamide | 1986 |
Molecular basis for the pathological actions of Clostridium perfringens iota toxin.
Topics: ADP Ribose Transferases; Bacterial Toxins; Clostridium perfringens; Hydroxylamine; Hydroxylamines; Kinetics; NAD; Niacinamide; Pentosyltransferases; Peptides | 1987 |
NAD metabolism and mitogen stimulation of human lymphocytes.
Topics: Animals; Cell Differentiation; Culture Media; Humans; Lymphocyte Activation; Lymphocytes; Mice; Mitogens; NAD; Niacin; Niacinamide; Phytohemagglutinins | 1985 |
Effects of 6-aminonicotinamide on cell growth, poly(ADP-ribose) synthesis and nucleotide metabolism.
Topics: 6-Aminonicotinamide; Adenosine Triphosphate; Animals; Cell Division; Cells, Cultured; Cricetinae; Cricetulus; DNA Repair; Female; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Nucleotides; Poly Adenosine Diphosphate Ribose | 1985 |
Mechanisms of poly(ADP-ribose) polymerase catalysis; mono-ADP-ribosylation of poly(ADP-ribose) polymerase at nanomolar concentrations of NAD.
Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; Animals; Cattle; Hydroxylamine; Hydroxylamines; Kinetics; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Poly(ADP-ribose) Polymerases | 1986 |
Activity of NMN+, nicotinamide ribose and analogs in alcohol oxidation promoted by horse-liver alcohol dehydrogenase. Improvement of this activity and structural requirements of the pyridine nucleotide part of the NAD+ coenzyme.
Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Alcohols; Animals; Coenzymes; Horses; Kinetics; Liver; NAD; Niacinamide; Nicotinamide Mononucleotide; Oxidation-Reduction; Pyridinium Compounds; Structure-Activity Relationship | 1986 |
Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.
Topics: Adenosine Triphosphate; Animals; Culture Media; DNA; DNA Repair; DNA, Single-Stranded; Enzyme Activation; Hydrogen Peroxide; Lead; Leukemia P388; Macrophages; Mice; NAD; Niacinamide; Poly(ADP-ribose) Polymerases; Time Factors | 1986 |
Long-term effects of exposure of pancreatic islets to nicotinamide in vitro on DNA synthesis, metabolism and B-cell function.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; DNA; Glucose; Insulin; Islets of Langerhans; Mice; Mice, Inbred Strains; NAD; Niacinamide; Oxidation-Reduction; Poly(ADP-ribose) Polymerase Inhibitors | 1986 |
DNA strand breaks, NAD metabolism, and programmed cell death.
Topics: Aphidicolin; Cell Survival; Diterpenes; DNA; DNA Repair; Humans; Immune System; Lymphocytes; Models, Biological; NAD; Niacinamide; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases | 1986 |
Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.
Topics: Actin Cytoskeleton; Actins; Adenosine Triphosphate; Animals; Benzamides; Calcium; Cell Line; Cell Survival; DNA Repair; Humans; Hydrogen Peroxide; In Vitro Techniques; Lymphocytes; Macrophages; Mice; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Theophylline | 1986 |
Defining the metabolic and growth responses of porcine haemophili to exogenous pyridine nucleotides and precursors.
Topics: Animals; Glucose; Haemophilus; NAD; NADP; Niacinamide; Nicotinamide Mononucleotide; Pyridinium Compounds; Swine | 1986 |
Metabolic consequences of DNA damage: the role of poly (ADP-ribose) polymerase as mediator of the suicide response.
Topics: Adenosine Triphosphate; Animals; Cell Survival; DNA Repair; Kinetics; Leukemia L1210; Methylnitronitrosoguanidine; Mice; NAD; Niacinamide; Poly(ADP-ribose) Polymerases | 1986 |
Rapid separation of dehydrogenases by affinity chromatography with new induced specificity phases.
Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Aldehydes; Chromatography, Affinity; Glutamate Dehydrogenase; Ketones; L-Lactate Dehydrogenase; NAD; NADP; Niacinamide; Oxidoreductases; Sepharose | 1986 |
5-Methylnicotinamide inhibits renal brush-border phosphate transport with no change in NAD.
Topics: Animals; Biological Transport; Kidney; Kinetics; Male; Microvilli; NAD; Niacin; Niacinamide; Parathyroid Glands; Phosphates; Rats; Rats, Inbred Strains; Sodium; Thyroidectomy | 1986 |
ADP-ribosylation in cultured cells treated with Clostridium difficile toxin B.
Topics: Adenosine Diphosphate Ribose; Bacterial Proteins; Bacterial Toxins; Carbon Radioisotopes; Cells, Cultured; Humans; NAD; Niacinamide | 1986 |
Pyridine nucleotide metabolism by extracts derived from Haemophilus parasuis and H. pleuropneumoniae.
Topics: Adenosine Triphosphate; Haemophilus; NAD; NADP; Niacinamide; Nicotinamide Mononucleotide; Pyridinium Compounds; Species Specificity | 1986 |
Pyridine nucleotide cycling and poly(ADP-ribose) synthesis in resting human lymphocytes.
Topics: Deoxyadenosines; Humans; Lymphocytes; NAD; Niacin; Niacinamide; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose | 1987 |
NAD+-mediated stimulation of adenylate cyclase in cardiac membranes.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Animals; Arginine; Cell Membrane; Colforsin; Enzyme Activation; Guanylyl Imidodiphosphate; Isoproterenol; Kinetics; Male; Manganese; Myocardium; NAD; NADP; Niacinamide; Rabbits; Sodium Fluoride | 1987 |
Synthesis of 5-beta-D-ribofuranosylnicotinamide and its N-methyl derivative. The isosteric and isoelectronic analogues of nicotinamide nucleoside.
Topics: NAD; Neoplasms; Niacinamide; Ribonucleosides | 1987 |
The cell-cycle dependent and the DNA-damaging agent-induced changes of cellular NAD content and their significance.
Topics: 4-Nitroquinoline-1-oxide; Benzamides; Cell Cycle; Cell Line; DNA Damage; DNA Replication; Humans; Interphase; Methyl Methanesulfonate; Methylnitronitrosoguanidine; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases | 1987 |
Dynamics of NAD in cortical nephron segments: effect of nicotinamide and of dietary phosphate intake.
Topics: Animals; Diet; NAD; Nephrons; Niacinamide; Parathyroid Glands; Phosphates; Rats; Rats, Inbred Strains; Thyroidectomy | 1987 |
Nicotinamide deficiency in human lymphocytes prevents the [3H]thymidine-induced adaptive response for the repair of X-ray-induced chromosomal damage.
Topics: Benzamides; DNA; DNA Repair; Humans; Lymphocytes; NAD; Niacinamide; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Thymidine | 1987 |
Metabolic consequences of DNA damage: alteration in purine metabolism following poly(ADP ribosyl)ation in human T-lymphoblasts.
Topics: Adenine; Adenosine Triphosphate; Benzamides; Cell Line; Cell Survival; DNA Damage; Glycine; Humans; Methylnitronitrosoguanidine; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose; Purines; T-Lymphocytes | 1987 |
Pyridine nucleotide analog interference with metabolic processes in mitogen-stimulated human T lymphocytes.
Topics: 6-Aminonicotinamide; Adenosine Triphosphate; Benzamides; Carbon Dioxide; Gluconates; Glucose-6-Phosphate; Glucosephosphates; Humans; Lymphocyte Activation; NAD; NADP; Niacinamide; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1987 |
Analysis of the effects of ethanol, fructose and nicotinamide on the free nucleotides of rat liver using high performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Ethanol; Fructose; Kinetics; Liver; NAD; NADP; Niacinamide; Rats; Ribonucleotides | 1987 |
Direction of elongation of poly(ADP-ribose) chains. Addition of residues at the polymerase-proximal terminus.
Topics: Adenosine Monophosphate; ADP Ribose Transferases; HeLa Cells; Histones; Humans; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases | 1987 |
Studies on rabbit kidney brush border membranes: relationship between phosphate transport, alkaline phosphatase and NAD.
Topics: Alkaline Phosphatase; Animals; Biological Transport; Cell Fractionation; In Vitro Techniques; Kidney; Microvilli; NAD; Niacinamide; Phosphates; Rabbits; Specimen Handling; Type C Phospholipases | 1987 |
Substrate specificity of nicotinamide methyltransferase isolated from porcine liver.
Topics: Animals; Glycerol; Hydrogen-Ion Concentration; Isoquinolines; Liver; Methyltransferases; Molecular Weight; NAD; Niacinamide; Nicotinamide N-Methyltransferase; Pyrazinamide; Pyridines; Quinolines; Substrate Specificity; Sulfhydryl Compounds; Swine; Tetrahydroisoquinolines | 1988 |
[Interaction of muscle glycogen phosphorylase b with nicotinic acid, nicotinamide, N-nicotinyl-gamma-aminobutyric acid and nicotinamide coenzymes].
Topics: Animals; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Muscles; NAD; NADP; Niacinamide; Nicotinic Acids; Phosphorylase b; Phosphorylases; Rabbits; Substrate Specificity | 1987 |
Utilization of tryptophan, nicotinamide and nicotinic acid as precursors for nicotinamide nucleotide synthesis in isolated rat liver cells.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; In Vitro Techniques; Liver; Male; NAD; NADP; Niacin; Niacinamide; Rats; Rats, Inbred Strains; Tryptophan | 1988 |
Nicotinamide protects target cells from cell-mediated cytolysis.
Topics: Benzamides; Calcium; Cell Survival; Cytotoxicity, Immunologic; DNA Damage; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Lymphocyte Activation; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Receptors, Immunologic; Receptors, Interleukin-2 | 1988 |
Fanconi's anemia lymphocytes: effect of caffeine, adenosine and niacinamide during G2 prophase.
Topics: Adenosine; Anemia, Aplastic; Caffeine; Chromosome Aberrations; DNA Repair; Fanconi Anemia; Humans; In Vitro Techniques; Interphase; Lymphocytes; NAD; Niacinamide | 1988 |
Tumor necrosis factor-mediated cytotoxicity involves ADP-ribosylation.
Topics: Adenosine Diphosphate Ribose; Adenosine Triphosphate; Animals; Benzamides; Cell Line; Cell Survival; Fibroblasts; Humans; Intracellular Fluid; Kinetics; Mice; NAD; Niacinamide; Recombinant Proteins; Tumor Necrosis Factor-alpha | 1988 |
Molecular mechanics calculation of geometries of NAD+ derivatives, modified in the nicotinamide group, in a ternary complex with horse liver alcohol dehydrogenase.
Topics: Alcohol Dehydrogenase; Amino Acids; Animals; Binding Sites; Chemical Phenomena; Chemistry; Energy Transfer; Horses; Liver; Molecular Conformation; NAD; Niacinamide; Protein Binding | 1988 |
Inhibitors of ADP-ribosyl transferase suppress the mitogenic actions exerted by tumour promoters, but not those evoked by peptide mitogens, in primary neonatal rat hepatocytes.
Topics: Animals; Animals, Newborn; Benzamides; Carcinogens; Cell Cycle; Cell Nucleus; DNA; Epidermal Growth Factor; In Vitro Techniques; Liver; Mitogens; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Tetradecanoylphorbol Acetate | 1988 |
[Fanconi's anemia: effect of treatment with a vitamin complex and with nicotinamide].
Topics: Anemia, Aplastic; Blood Cell Count; Child; Chromosome Aberrations; Cytogenetics; Fanconi Anemia; Female; Humans; Male; NAD; Niacinamide; Oxymetholone; Vitamins | 1988 |
Similar sensitivity of human lymphoblast cells proficient or deficient in nucleotide biosynthesis to the cytotoxic and cell cycle effects of 3-aminobenzamide.
Topics: Aminobenzoates; Benzamides; Cell Cycle; Cell Line; Cell Survival; Humans; Hypoxanthine; Hypoxanthines; Lymphocytes; meta-Aminobenzoates; NAD; NAD+ Nucleosidase; Niacinamide; Nucleotides; Poly(ADP-ribose) Polymerase Inhibitors; Thymidine | 1985 |
Quantitative and mechanistic aspects of the hydroperoxide-induced release of Ca2+ from rat liver mitochondria.
Topics: Animals; Biological Transport; Calcium; Female; Glutathione; Glutathione Reductase; Hydrolysis; In Vitro Techniques; Mitochondria, Liver; NAD; NADP; Niacinamide; Oxidation-Reduction; Peroxides; Protons; Rats; Rats, Inbred Strains | 1985 |
Specificity of inhibitors of poly(ADP-ribose) synthesis. Effects on nucleotide metabolism in cultured cells.
Topics: Animals; Benzamides; Cell Division; Cricetinae; Deoxyribonucleotides; DNA; Methylnitrosourea; Mice; NAD; NAD+ Nucleosidase; Niacinamide; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Ribonucleotides | 1985 |
Effect of insulin on renal phosphorus handling in the rat: interaction with PTH and nicotinamide.
Topics: Animals; Biological Transport; Cyclic AMP; Drug Interactions; Extracellular Space; Glomerular Filtration Rate; Insulin; Kidney; Kidney Cortex; Male; NAD; Niacinamide; Parathyroid Glands; Parathyroid Hormone; Phosphorus; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Effects of hyperthermia and nicotinamide on DNA repair synthesis, ADP-ribosyl transferase activity, NAD+ and ATP pools, and cytotoxicity in gamma-irradiated human mononuclear leukocytes.
Topics: Adenosine Triphosphate; Cesium Radioisotopes; DNA Repair; Gamma Rays; Hot Temperature; Humans; Monocytes; NAD; Niacinamide; Nucleotidyltransferases; Poly(ADP-ribose) Polymerases | 1986 |
NAD+ glycohydrolase of the plasma membrane prepared from glial and neuronal cells.
Topics: Adenosine Diphosphate Ribose; Adenosine Triphosphate; Animals; Binding, Competitive; Brain; Cell Membrane; Cells, Cultured; Chick Embryo; Guanosine Triphosphate; Hydrogen-Ion Concentration; Kinetics; NAD; NAD+ Nucleosidase; Neuroglia; Neurons; Niacinamide; Rats | 1986 |
Formation of the N'-methylnicotinamide adenine dinucleotide derivative of NAD in intact rat pituitary tumor GH3 and human promyelocytic leukemia HL-60 cells.
Topics: Adenosine Triphosphate; Animals; Cell Line; Guanosine Triphosphate; Humans; Leukemia, Myeloid, Acute; NAD; NAD+ Nucleosidase; Niacinamide; Nucleotidyltransferases; Pituitary Neoplasms; Poly(ADP-ribose) Polymerases; Rats; Substrate Specificity; Time Factors | 1986 |
A surface NAD-glycohydrolase of human platelets may influence their aggregation.
Topics: Adenosine; Adenosine Diphosphate Ribose; Blood Platelets; Cell Membrane; Humans; NAD; NAD+ Nucleosidase; Niacinamide; Platelet Aggregation; Thrombin | 1986 |
Direct observation of the NAD glycohydrolase reaction in human erythrocytes using NMR spectroscopy.
Topics: Adenosine Diphosphate Ribose; Erythrocytes; Humans; Kinetics; Magnetic Resonance Spectroscopy; N-Glycosyl Hydrolases; NAD; NAD+ Nucleosidase; Niacinamide | 1985 |
Mechanism of alloxan-induced calcium release from rat liver mitochondria.
Topics: Alloxan; Animals; Calcium; Egtazic Acid; Female; Intracellular Membranes; Kinetics; Membrane Potentials; Mitochondria, Liver; NAD; NADP; Niacin; Niacinamide; Oxygen Consumption; Rats; Rats, Inbred Strains; Selenium | 1985 |
Effects of diazinon on nucleotide and amino acid contents of chick embryos. Teratogenic considerations.
Topics: Abnormalities, Drug-Induced; Amino Acids; Animals; Chick Embryo; Diazinon; Insecticides; NAD; Niacinamide; Nucleotides; Tryptophan | 1985 |
High-performance liquid chromatographic determination of N1-alkylnicotinamide in urine.
Topics: Adult; Alkylation; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Humans; Male; Methylation; Middle Aged; NAD; NADP; Naphthyridines; Niacinamide; Spectrometry, Fluorescence | 1985 |
The relationship of nicotinamide adenine dinucleotide to the chondrogenic differentiation of limb mesenchymal cells.
Topics: Adenosine Diphosphate Ribose; Animals; Benzamides; Cartilage; Cell Differentiation; Cell Division; Cells, Cultured; Chick Embryo; Extremities; Mesoderm; NAD; Niacin; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Proteoglycans; Sulfates | 1985 |
The influence of nicotinamide on the course of experimental bronchial asthma in guinea pig.
Topics: Animals; Asthma; Eosinophils; Guinea Pigs; Histamine Release; Lung; Mast Cells; NAD; Niacinamide; Ovalbumin | 1973 |
The action of nicotinamide on the release of histamine.
Topics: Airway Resistance; Animals; Blood Pressure; Depression, Chemical; Dogs; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; In Vitro Techniques; Lung; Mast Cells; NAD; Niacinamide; Rats | 1974 |
The inhibitory effect of nicotinamide on asthma-like symptoms and eosinophilia in guinea pigs, anaphylactic mast cell degranulation in mice, and histamine release from rat isolated peritoneal mast cells by compound 48-80.
Topics: Aerosols; Anaphylaxis; Animals; Antigens; Asthma; Eosinophilia; Guinea Pigs; Histamine Release; Mast Cells; NAD; Niacinamide; Ovalbumin; p-Methoxy-N-methylphenethylamine | 1974 |
Studies on the mitochondrial energy-linked pyridine nucleotide transhydrogenase.
Topics: Aniline Compounds; Animals; Cattle; Deuterium; Hydrogen-Ion Concentration; Kinetics; Magnesium Sulfate; Mitochondria, Muscle; Myocardium; NAD; NADH, NADPH Oxidoreductases; NADP; Naphthalenes; Niacinamide; Oxidoreductases; Spectrophotometry; Structure-Activity Relationship; Succinates; Sulfonic Acids; Tritium | 1973 |
The role of the pentose phosphate shunt in glucose induced insulin release: in vitro studies with 6-aminonicotinamide, methylene blue, NAD + , NADH, NADP + , NADPH and nicotinamide on isolated pancreatic rat islets.
Topics: Animals; Carbon Isotopes; Female; Glucose; In Vitro Techniques; Insulin; Islets of Langerhans; Methylene Blue; NAD; NADP; Niacinamide; Pentosephosphates; Rats; Time Factors | 1973 |
Biosynthesis of pyridine nucleotides in early embryos of the mouse (Mus musculus).
Topics: Animals; Azaserine; Carbon Isotopes; Chorionic Gonadotropin; Embryo Implantation; Embryo, Mammalian; Embryonic and Fetal Development; Female; Fertilization; Humans; Male; Mice; Mitosis; NAD; NADP; Niacinamide; Nicotinamide Mononucleotide; Nicotinic Acids; Ovum; Pregnancy; Pyridines | 1973 |
Pyridine nucleotide metabolism in Escherichia coli. 3. Biosynthesis from alternative precursors in vivo.
Topics: Amidohydrolases; Biological Transport; Carbon Isotopes; Cell Membrane; Cell-Free System; Culture Media; Escherichia coli; Kinetics; NAD; NADP; Niacinamide; Nicotinic Acids; Species Specificity; Structure-Activity Relationship; Tritium | 1973 |
Pyridine nucleotide metabolism in Escherichia coli. IV. Turnover.
Topics: Adenine; Carbon Isotopes; Escherichia coli; Kinetics; Mathematics; Models, Chemical; Mutation; NAD; NADP; Niacinamide; Nicotinic Acids; Nucleotides; Polynucleotide Ligases; Species Specificity; Tritium | 1973 |
Influence of nicotinamide and pyridine nucleotides on streptozotocin and alloxan-induced pancreatic B cell cytotoxicity.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Islets of Langerhans; Male; Mice; NAD; NADP; Necrosis; Niacinamide; Pancreas; Rats; Streptozocin; Time Factors | 1973 |
The purification of nicotinamide nucleotide-dependent dehydrogenases on immobilized cofactors.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Aminocaproates; Chromatography; Chromatography, Affinity; Glucosephosphate Dehydrogenase; NAD; NADP; Niacinamide; Oxidoreductases; Polysaccharides; Pseudomonas; Rhodobacter sphaeroides; Ribonucleotides; Saccharomyces cerevisiae; Threonine | 1973 |
Electrochemical redox pattern for nicotinamide species in nonaqueous media.
Topics: Electrochemistry; NAD; NADP; Niacinamide; Oxidation-Reduction; Polarography; Potentiometry | 1973 |
Release of DNA polymerase from rat liver chromatin on incubation with NAD.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Nucleus; Chromatin; DNA Nucleotidyltransferases; Liver; Male; Micrococcus; NAD; NADP; Niacinamide; Nucleoside Diphosphate Sugars; Oxidation-Reduction; Rats; Structure-Activity Relationship; Time Factors; Tritium | 1973 |
Pyridine nucleotide metabolism in mammalian cells in culture.
Topics: Animals; Azaserine; Carbon Radioisotopes; Cell Line; Chromatography, Paper; Cricetinae; Depression, Chemical; Half-Life; Humans; Hypoxanthines; Isotope Labeling; Kidney; Mice; NAD; NADP; Niacinamide; Nicotinic Acids; Ribonucleosides; Spectrometry, Fluorescence; Time Factors; Tritium | 1973 |
Effects of leucine and isoleucine on nicotinamide nucleotides of erythrocytes.
Topics: Adult; Blood Glucose; Carbon Dioxide; Carbon Radioisotopes; Drug Synergism; Erythrocytes; Feces; Glycolysis; Humans; Isoleucine; Lactates; Leucine; Male; NAD; NADP; Niacinamide; Nicotinamide Mononucleotide; Oxidation-Reduction; Pyridines; Ribonucleotides; Time Factors | 1973 |
Metabolic alterations in the axotomized superior cervical ganglion of the rat. II. The pentose phosphate pathway.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Ganglia, Spinal; Gluconates; Glucose; Glucosephosphate Dehydrogenase; Isocitrate Dehydrogenase; Isomerases; Lipid Metabolism; Malate Dehydrogenase; Male; NAD; NADP; Nerve Regeneration; Niacinamide; Oxygen Consumption; Pentosephosphates; Phosphogluconate Dehydrogenase; Rats; RNA; Transketolase | 1974 |
Natural abundance 13C nuclear magnetic resonance spectra of nicotinamide adenine dinucleotide and related nucleotides.
Topics: Adenosine Monophosphate; Carbon Isotopes; Chemical Phenomena; Chemistry; Magnetic Resonance Spectroscopy; Molecular Conformation; NAD; NADP; Niacinamide; Nicotinamide Mononucleotide; Oxidation-Reduction; Protons; Ribose; Time Factors | 1973 |
Autoradiographic studies of pyridine nucleotide metabolism in human culture cells.
Topics: Alcohol Oxidoreductases; Autoradiography; Azaserine; Cell Division; Cell Line; Cells, Cultured; Histocytochemistry; Histones; Humans; Kinetics; Myoglobin; NAD; NADP; Niacinamide; Nicotinic Acids; Nucleotides; Osmium; Oxides; Protein Binding; Pyridines; Serum Albumin, Bovine; Thymidine; Time Factors; Tritium | 1974 |
Reaction of ozone with nicotinamide and its derivatives.
Topics: Binding Sites; Carbon Radioisotopes; Chromatography, DEAE-Cellulose; Chromatography, Gas; Hydrogen-Ion Concentration; Kinetics; Mass Spectrometry; Molecular Conformation; NAD; NADP; Niacinamide; Oxidation-Reduction; Ozone; Spectrophotometry; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 1974 |
Comparative aspects of glucose catabolism in Staphylococcus aureus and S. epidermidis.
Topics: Aerobiosis; Coagulase; Fructosephosphates; Genetic Variation; Glucose; Glucosephosphate Dehydrogenase; Isoenzymes; NAD; NADP; Niacinamide; Nicotinic Acids; Oxidation-Reduction; Phosphogluconate Dehydrogenase; Staphylococcus; Thiamine | 1974 |
Evidence for a proton-dependent regulation of mitochondrial nicotinamide-nucleotide transhydrogenase.
Topics: Anilino Naphthalenesulfonates; Animals; Cattle; Cyanides; Glutathione; Hydrazones; Hydrogen-Ion Concentration; Kinetics; Malonates; Membranes; Mitochondria, Muscle; Myocardium; NAD; NADH, NADPH Oxidoreductases; NADP; Niacinamide; Oxidation-Reduction; Spectrometry, Fluorescence; Time Factors | 1974 |
Purification and kinetic properties of acyl and alkyl dihydroxyacetone phosphate oxidoreductase.
Topics: Acetone; Alcohol Oxidoreductases; Animals; Binding, Competitive; Borohydrides; Carcinoma, Ehrlich Tumor; Centrifugation, Density Gradient; Chromatography, Gel; Chromatography, Ion Exchange; Deoxycholic Acid; Drug Stability; Electrophoresis, Paper; Guinea Pigs; Kinetics; Membranes; Mice; Microsomes; Mitochondria, Liver; NAD; NADP; Niacinamide; Organophosphorus Compounds; Palmitic Acids; Phosphatidic Acids; Phosphorus Radioisotopes; Structure-Activity Relationship; Time Factors; Tritium | 1974 |
[Nicotinic acid concentration in the blood and urine of syringomyelia patients during deep x-ray therapy].
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Therapy, Combination; Female; Glucosephosphate Dehydrogenase; Humans; Male; Middle Aged; NAD; NADP; Niacinamide; Nicotinic Acids; Pellagra; Radiotherapy; Syringomyelia; Thiamine; Thiamine Pyrophosphate; Vitamin B 12 | 1974 |
Protective effect of adenosine and nicotinamide against audiogenic seizure.
Topics: Acoustic Stimulation; Adenosine; Adenosine Triphosphate; Animals; Blood Pressure; Brain Chemistry; Caffeine; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Mice; Mice, Inbred Strains; NAD; Niacinamide; Norepinephrine; Phosphocreatine; Phosphorus Radioisotopes; Time Factors | 1974 |
The biosynthesis and turnover of nicotinamide adenine dinucleotide in enucleated culture cells.
Topics: Autoradiography; Azaserine; Bone Marrow; Bone Marrow Cells; Cell Fractionation; Cell Line; Cell Nucleus; Cells, Cultured; Chromatography, Paper; Microsomes; N-Glycosyl Hydrolases; NAD; NADP; Niacinamide; Nicotinamide Mononucleotide; Nicotinic Acids; Tritium | 1974 |
The relation between urinary excretion of tryptophan and niacin metabolites and pyridine nucleotides in the liver in rats fed a tryptophan-deficient diet.
Topics: Adenine Nucleotides; Animal Nutritional Physiological Phenomena; Animals; Body Weight; Deficiency Diseases; Female; Liver; NAD; NADP; Niacinamide; Nicotinic Acids; Nucleotides; Organ Size; Pyridones; Rats; Tryptophan | 1974 |
Cerebral energy reserves and glycolysis in neural tissue of 6-aminonicotinamide-treated mice.
Topics: Adenosine Triphosphate; Amines; Animals; Brain; Brain Chemistry; Cerebellum; Energy Metabolism; Fructosephosphates; Gluconates; Glucose; Glucosephosphates; Glycogen; Hypoxia, Brain; Ischemia; Isocitrates; Lactates; Malates; Mice; NAD; NADP; Niacinamide; Phosphocreatine; Ribose | 1974 |
Pyridine nucleotides in the thyroid gland. II. Effect of nicotinamide, nicotinic acid and L-tryptophan administration.
Topics: Animals; Kinetics; Male; NAD; NADP; Niacin; Niacinamide; Oxidation-Reduction; Rats; Thyroid Gland; Tryptophan | 1968 |
An assay procedure for nicotinamide-adenine dinucleotides in rat liver and other tissues.
Topics: Alcohol Oxidoreductases; Animals; Buffers; Chemistry Techniques, Analytical; Edetic Acid; Ethanol; Glucosephosphate Dehydrogenase; In Vitro Techniques; Indicators and Reagents; Liver; NAD; NADP; Niacinamide; Phenazines; Phenols; Phosphates; Rats; Spectrophotometry; Subcellular Fractions; Tryptophan | 1964 |
The effects of x-radiation and nicotinamide on the respiration of rat thymocytes.
Topics: Animals; Cell Nucleus; Chromosomes; Cyanides; Histones; In Vitro Techniques; Lactates; NAD; Niacinamide; Oxidative Phosphorylation; Oxygen Consumption; Radiation Effects; Rats; Thymus Gland | 1965 |
Multiple inhibition of yeast alcohol dehydrogenase.
Topics: Adenine Nucleotides; Alcohol Oxidoreductases; Chemical Phenomena; Chemistry; Enzymes; In Vitro Techniques; NAD; Niacinamide; Phenanthrolines; Spectrophotometry; Yeasts | 1965 |
Inhibition of the methylation of nicotinamide by chlorpromazine.
Topics: Alkylation; Animals; Catalysis; Chlorpromazine; In Vitro Techniques; Kinetics; Liver; Mice; NAD; Niacinamide; Subcellular Fractions | 1965 |
Spectral and biological changes induced in nicotinic acid and related compounds by ultraviolet light.
Topics: Chromatography; NAD; Niacinamide; Nicotinic Acids; Pyridines; Pyridones; Radiation Effects; Radiochemistry; Spectrophotometry; Ultraviolet Rays | 1965 |
Inhibition of glutamic dehydrogenase by N-1-alkylnicotinamide chlorides.
Topics: Amino Acid Oxidoreductases; Animals; Cattle; Chlorides; Enzymes; Glutamate Dehydrogenase; In Vitro Techniques; Kinetics; Liver; NAD; Niacinamide; Spectrophotometry | 1966 |
The enzymatic reduction of nicotinamide N-oxide.
Topics: Animals; In Vitro Techniques; Liver; NAD; Niacinamide; Oxides; Spectrophotometry; Subcellular Fractions; Swine | 1966 |
On the relative efficacy of nicotinamide and nicotinic acid as precursors of nicotinamide adenine dinucleotide.
Topics: Animals; Blood; Carbon Isotopes; In Vitro Techniques; Liver; NAD; Niacinamide; Nicotinic Acids; Rats; Urine | 1966 |
Nicotinamide deamidase in Ehrlich ascites tumor cells.
Topics: Amidohydrolases; Animals; Carcinoma, Ehrlich Tumor; Chromatography, Paper; In Vitro Techniques; Mice; NAD; Niacinamide | 1966 |
The reduction of nicotinamide N-oxide by xanthine oxidase.
Topics: Animals; Cyanides; Hot Temperature; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Mercaptoethanol; Milk; NAD; Niacinamide; Oxides; Spectrophotometry; Swine; Xanthine Oxidase | 1966 |
The effect of x-irradiation on the nicotinamide adenine dinucleotides (NAD-NADH) content of rat thymocytes.
Topics: Animals; Cell Nucleus; Fluorescence; NAD; Niacinamide; Pyridines; Radiation Effects; Rats; Spectrophotometry; Statistics as Topic; Thymus Gland | 1966 |
The pyridine nucleotide cycle and its role in the biosynthesis of ricinine by Ricinus communis L.
Topics: Alkaloids; Carbon Isotopes; NAD; Niacinamide; Nicotinic Acids; Plants, Toxic; Pyridines; Ricinus | 1966 |
A hydrophobic region at the active site of yeast alcohol dehydrogenase.
Topics: Alcohol Oxidoreductases; Catalysis; Enzymes; Kinetics; NAD; Niacinamide; Yeasts | 1964 |
Transfer of H from succinate to DPN catalyzed by the Slater-Keilin-Hartree preparation.
Topics: Catalysis; In Vitro Techniques; NAD; Niacinamide; Succinate Dehydrogenase; Tritium | 1964 |
Effect of hypophysectomy on pyridine nucleotide metabolism. The role of nicotinamide.
Topics: Animals; Hypophysectomy; Liver; NAD; Niacinamide; Nicotinic Acids; Pyridones; Rats | 1967 |
[The role of nicotinamide in the synthesis of NAD in Ehrlich ascites tumor cells].
Topics: Animals; Carcinoma, Ehrlich Tumor; Chromatography, Ion Exchange; In Vitro Techniques; N-Glycosyl Hydrolases; NAD; Niacinamide; Nicotinic Acids | 1966 |
The mechanism of pyridine nucleotide synthesis in Ehrlich ascites carcinoma and host liver.
Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Chromatography, Ion Exchange; Chromatography, Paper; Female; Liver; Mice; NAD; Niacinamide; Nicotinic Acids | 1967 |
Nicotinamide adenine dinucleotide kinase from Azotobacter vinelandii. I. Purification and properties of the enzyme.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Azotobacter; Cellulose; Chromatography; Enzymes; Ethylmaleimide; Glutathione; Glycerol; Hot Temperature; Kinetics; Mercaptoethanol; NAD; Niacinamide; Nucleotides; Nucleotidyltransferases; Spectrophotometry; Sulfhydryl Compounds | 1967 |
Vitamin E deficiency in the rat. 3. The relationship of nicotinamide adenine dinucleotide to respiratory decline.
Topics: Animals; Hydroxybutyrate Dehydrogenase; In Vitro Techniques; Liver; Microsomes; Mitochondria; NAD; Niacinamide; Nucleotidases; Oxygen Consumption; Rats; Vitamin E Deficiency | 1967 |
The low-temperature luminescent spectra of adenine and its derivatives.
Topics: Adenine; Adenine Nucleotides; Cold Temperature; Luminescent Measurements; NAD; Niacinamide; Nucleosides; Purines; Pyrimidines; Spectrum Analysis | 1966 |
Prevention by antidepressant drugs of reserpine effect on pyridine nucleotide metabolism.
Topics: Aminopyrine; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Atropine; Benactyzine; Caffeine; Chlorpheniramine; Chlorpromazine; Female; Hexobarbital; Hydralazine; Hypothalamus; Imipramine; Iproniazid; Isoniazid; Liver; Meprobamate; Methacholine Compounds; Morphine; NAD; Niacinamide; Pargyline; Pentobarbital; Phenylbutazone; Phenytoin; Quinacrine; Rats; Reserpine; Tranylcypromine; Tripelennamine; Zoxazolamine | 1966 |
Studies on the polymer of adenosine diphosphate ribose. I. Enzymic formation from nicotinamide adenine dinuclotide in mammalian nuclei.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Carbon Isotopes; Cell Nucleus; In Vitro Techniques; Liver; NAD; Niacinamide; Nucleotidyltransferases; Phosphoric Monoester Hydrolases; Polynucleotides; Rats; Ribose | 1967 |
The effect of traumatic shock on metabolism of ethyl alcohol in mice. 3. The interaction of treatments by nicotinamide, diphosphopyridinenucleotide and traumatic shock on the rate of whole-body metabolism of ethyl alcohol.
Topics: Animals; Ethanol; Femoral Fractures; Injections, Intraperitoneal; Mice; NAD; Niacinamide; Shock, Traumatic | 1966 |
[Studies of the regulation of NAD synthesis in the rat liver].
Topics: Adrenocorticotropic Hormone; Animals; Liver; NAD; Niacinamide; Rats | 1966 |
[Effect of nicotinamide on the NAD level and the activity of NAD-glycohydrolase in the skeletal muscles and the liver].
Topics: Animals; Hydrolases; Liver; Muscles; N-Glycosyl Hydrolases; NAD; Niacinamide; Nicotinic Acids; Rats | 1965 |
The pathway of synthesis of mammary-gland nicotinamide-adenine dinucleotide.
Topics: Animals; Female; Lactation; Liver; Mammary Glands, Animal; NAD; Niacinamide; Pregnancy; Rats | 1967 |
Participation of nicotinamide mononucleotide in pyridine nucleotide synthesis in tumor and host liver.
Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Liver Neoplasms; Mice; NAD; Niacinamide; Nucleotides; Pyridines | 1967 |
Effect of the components parts of nicotinamide adenine dinucleotide (NAD) as inhibitors of lactic dehydrogenase.
Topics: Adenine; Adenine Nucleotides; Buffers; Enzymes; Kinetics; L-Lactate Dehydrogenase; Lactates; NAD; Niacinamide; Pentosephosphates; Ribose; Semicarbazides; Spectrophotometry | 1967 |
Interactions of substrates, inhibitors, and coenzymes at the active site of horse liver alcohol dehydrogenase.
Topics: Adenine Nucleotides; Alcohol Oxidoreductases; Alcohols; Aldehydes; Amides; Animals; Catalysis; Chelating Agents; Chemical Phenomena; Chemistry; Enzymes; Fatty Acids; Horses; Imidazoles; Kinetics; Liver; NAD; Niacinamide; Nicotinic Acids; Phenanthrolines; Pyrazoles; Pyridines; Sulfhydryl Compounds; Zinc | 1967 |
[Characteristics of NAD metabolism in the brain--with reference to a comparison with the liver].
Topics: Aging; Animals; Brain; Carbon Tetrachloride Poisoning; Chlorpromazine; Liver; Male; NAD; Niacinamide; Nicotinic Acids; Rats; Reserpine | 1966 |
Effect of N1-alkylnicotinamide chlorides on glutamate oxidation in rat liver mitochondria.
Topics: Alcohol Oxidoreductases; Alkylation; Animals; Chlorides; Glutamate Dehydrogenase; Glutamates; Mitochondria, Liver; NAD; Niacinamide; Rats; Spectrophotometry | 1967 |
Biosynthesis of nicotinamide-adenine dinucleotide in Escherichia coli.
Topics: Amidohydrolases; Carbon Isotopes; Chromatography, Paper; Escherichia coli; Mutation; NAD; Niacinamide | 1967 |
Polymerization of the adenosine 5'-diphosphate ribose moiety of NAD by rat liver nuclear enzyme.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Carbon Isotopes; Cell Nucleus; Chromatography, Ion Exchange; Liver; NAD; Niacinamide; Nucleotidyltransferases; Phosphoric Monoester Hydrolases; Phosphorus Isotopes; Polynucleotides; Rats; Ribose | 1967 |
[Stimulation of DPN metabolic processes in ascites tumors by low dosage roentgen irradiation and trenimon].
Topics: Animals; Carcinoma, Ehrlich Tumor; Culture Techniques; DNA; Mice; N-Glycosyl Hydrolases; NAD; Niacinamide; Nicotinic Acids; Radiation Effects; Rats; Sarcoma, Yoshida; Triaziquone | 1966 |
Flavin-pyridinium biscoenzyme analogs. Synthesis and reactivity.
Topics: Catalysis; Coenzymes; Enzymes; Flavins; Kinetics; Models, Biological; NAD; Niacinamide; Oxidation-Reduction; Pyridinium Compounds; Spectrophotometry; Thioctic Acid | 1967 |
[Intramolecular correlation of coenzymes. 3. Nicotinamide-pentamethylene-adenosine-pyrophosphate].
Topics: Adenosine Triphosphate; Coenzymes; Models, Chemical; NAD; Niacinamide; Spectrum Analysis | 1966 |
Measurements of tryptophan pyrrolase in vivo: induction and feedback inhibition.
Topics: Adrenalectomy; Carbon Dioxide; Carbon Isotopes; Enzyme Induction; Feedback; Hypophysectomy; Liver; NAD; Niacinamide; Nicotinic Acids; Tryptophan; Tryptophan Oxygenase | 1967 |
Studies on the mode of action of diphtheria toxin. V. Inhibition of peptide bond formation by toxin and NAD in cell-free systems and its reversal by nicotinamide.
Topics: Amino Acids; Animals; Diphtheria Toxin; HeLa Cells; Horses; In Vitro Techniques; L Cells; Leucine; Mice; NAD; Niacinamide; Phenylalanine; Rabbits; Reticulocytes; Transferases | 1967 |
Polymerization of the adenosine 5'-diphosphate-ribose moiety of nicotinamide-adenine dinucleotide by nuclear enzyme. I. Enzymatic reactions.
Topics: Adenosine Triphosphate; Animals; Carbon Isotopes; Catalysis; Cell Nucleus; Deoxyribonucleases; Depression, Chemical; Hydrogen-Ion Concentration; Liver; Male; N-Glycosyl Hydrolases; NAD; Niacinamide; Nucleotides; Phosphorus Isotopes; Rats | 1967 |
[Demonstration of the biosynthesis in vivo of a compound polymer, polyadenosine diphosphoribose in the nucleus of the liver of chickens].
Topics: Adenine Nucleotides; Animals; Cell Nucleus; Chickens; Chromatography; Liver; NAD; Niacinamide; Polymers; Radiochemistry | 1967 |
Stress and the maintenance of nicotinamide-induced hepatic nicotinamide adenine dinucleotide elevation by chlorpromazine.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Ascorbic Acid; Chlorpromazine; Extremities; Liver; Male; NAD; Niacinamide; Pituitary-Adrenal System; Rats; Stress, Physiological | 1967 |
Pathways of nicotinamide adenine dinucleotide biosynthesis in nicotinic acid or nicotinamide requiring microorganisms.
Topics: Amidohydrolases; Carbon Isotopes; Cell-Free System; Centrifugation; Chromatography, Ion Exchange; Escherichia coli; Lactobacillus; Leuconostoc; Models, Biological; NAD; Niacinamide; Nicotinic Acids; Nucleotidyltransferases; Pyridines; Spectrophotometry; Transferases; Ultrasonics | 1967 |
The polymerization of adenosine 5'-diphosphate-ribose moiety of NAD by nuclear enzyme. II. Properties of the reaction product.
Topics: Adenosine Triphosphate; Animals; Carbon Isotopes; Catalysis; Cell Nucleus; Centrifugation, Density Gradient; Chromatography, Paper; Liver; Models, Structural; NAD; Niacinamide; Nucleotides; Phosphorus Isotopes; Rats; Spectrophotometry | 1967 |
The use of nicotinamide to modify the toxicity of streptozotocin diabetes without loss of antitumor activity.
Topics: Animals; Antibiotics, Antineoplastic; Diabetes Mellitus; Drug Antagonism; Islets of Langerhans; Liver; Mice; NAD; Niacinamide | 1967 |
[Nicotinacid amide as a stabilizing additive in cold storage of blood].
Topics: Blood Preservation; Erythrocytes; Humans; NAD; Niacinamide; Refrigeration | 1966 |
Inhibition of yeast alcohol dehydrogenase by N1-benzylpyridinium chlorides.
Topics: Adenine Nucleotides; Alcohol Oxidoreductases; Benzene Derivatives; Binding Sites; Chlorides; Ethanol; NAD; Niacinamide; Pyridinium Compounds | 1968 |
The pathway of biosynthesis of nicotinamide-adenine dinucleotide in rat mammary gland.
Topics: Animals; Female; Glucosyltransferases; Kinetics; Lactation; Mammary Glands, Animal; Models, Biological; NAD; Niacinamide; Nicotinic Acids; Nucleotides; Nucleotidyltransferases; Pregnancy; Rats; Tryptophan | 1968 |
[Demonstration of 3-hydroxyanthranilic acid oxygenase in Saccharomyces cerevisiae].
Topics: Enzyme Repression; Kinetics; NAD; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Oxygenases; Pyridines; Saccharomyces | 1967 |
Properties of the nicotinamide adenine dinucleotide-binding sites of L-alpha-glycerophosphate dehydrogenase.
Topics: Adenine Nucleotides; Animals; Binding Sites; Glycerolphosphate Dehydrogenase; Kinetics; NAD; Niacinamide; Nucleosides; Rabbits; Spectrophotometry | 1968 |
Effect of whole-body gamma-irradiation on the subcellular distribution of proteinases in rat thymus.
Topics: Animals; Cobalt Isotopes; Depression, Chemical; Hemoglobins; Histones; Male; NAD; Niacinamide; Peptide Hydrolases; Radiation Effects; Rats; Thymus Gland | 1967 |
Enzymic adenosine diphosphate ribosylation of histone and poly adenosine diphosphate ribose synthesis in rat liver nuclei.
Topics: Adenine Nucleotides; Animals; Carbon Isotopes; Cell Nucleus; DNA; Globulins; Histones; Liver; Molecular Weight; NAD; Niacinamide; Nucleotides; Polynucleotides; Proteins; Rats | 1968 |
Evidence for an acid-catalyzed alpha,beta epimerization in pyridine nucleotides.
Topics: Adenine Nucleotides; Buffers; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Models, Chemical; NAD; Niacinamide; Nucleotides; Optical Rotatory Dispersion; Pyridines; Spectrum Analysis; Stereoisomerism | 1968 |
Mechanisms of the primary acid modification reaction of reduced diphosphopyridine nucleotide models.
Topics: Benzene Derivatives; Chemical Phenomena; Chemistry; Crystallography; Deuterium; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; NAD; Niacinamide; Oxidation-Reduction; Pyridines; Spectrophotometry; Tritium | 1968 |
Studies on the biosynthesis of nicotinamide-adenine dinucleotide in the brain.
Topics: Animals; Blood-Brain Barrier; Brain; Carbon Isotopes; Cisterna Magna; Injections, Intraperitoneal; Mice; Models, Biological; NAD; Niacinamide; Nicotinic Acids; Nucleosides; Nucleotides; Phosphorus Isotopes; Pyridines; Rats; Time Factors | 1968 |
[The influence of a fractionated x-irradiation on the NAD-content of solid tumors and the host liver].
Topics: Animals; Carcinoma, Ehrlich Tumor; Liver Neoplasms; Mice; NAD; Neoplasm Transplantation; Niacinamide; Peritoneal Neoplasms | 1967 |
[Hydrogen transfer through coenzyme models in aqueous medium].
Topics: Chemical Phenomena; Chemistry; Coenzymes; Hydrogen; NAD; Niacinamide; Water | 1968 |
Identity of nuclear NAD nucleosidase with a polyADP-ribose forming enzyme in Ehrlich ascites tumor cells.
Topics: Adenine Nucleotides; Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell Nucleus; Depression, Chemical; Kinetics; Microsomes; N-Glycosyl Hydrolases; NAD; Niacinamide; Polynucleotides; Ribose; Tritium | 1968 |
Biochemical study on the host response to tuberculous infection. IV. Influences of isoniazid, streptomycin, nicotinamide, and cortisone.
Topics: Animals; Cortisone; Drug Resistance, Microbial; Isoniazid; Mice; Mycobacterium tuberculosis; N-Glycosyl Hydrolases; NAD; Niacinamide; Streptomycin; Tuberculosis | 1968 |
Regulation of pyridine nucleotide coenzymes.
Topics: Adenosine Triphosphate; Animals; Azaserine; Bacillus subtilis; Carbon Isotopes; Liver; Mice; Mycobacterium tuberculosis; NAD; Niacinamide; Nucleotidases; Nucleotides; Pyridines | 1968 |
The biosynthesis of NAD in the liver of irradiated mice.
Topics: Adrenalectomy; Animals; Carbon Isotopes; Chromatography; Hydrocortisone; Hydrolases; Liver; Mice; Mixed Function Oxygenases; N-Glycosyl Hydrolases; NAD; Niacinamide; Nicotinic Acids; Nucleotides; Radiation Effects; Transaminases; Tryptophan; Tryptophan Oxygenase | 1968 |
Polymerization of ADPR moiety of NAD by nuclear enzyme preparation.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Carbon Isotopes; Chromatography; Deoxyribonucleases; DNA; Hydrogen-Ion Concentration; Liver; NAD; Niacinamide; Nucleotidases; Nucleotidyltransferases; Phosphoric Monoester Hydrolases; Phosphorus Isotopes; Polymers; Rats; Ribonucleases; Ribose; RNA; Spectrum Analysis; Venoms | 1968 |
Poly adenosine diphosphate ribose synthesis and nicotinamide adenine dinucleotide transglycosidases.
Topics: Animals; Carbon Isotopes; Centrifugation; Chemical Phenomena; Chemistry; Chromatography; Cytoplasm; DNA; Escherichia coli; Isonicotinic Acids; Lactobacillus; Liver; Mammals; N-Glycosyl Hydrolases; NAD; Niacinamide; Nicotinic Acids; Nucleoproteins; Nucleotidyltransferases; Phosphoric Monoester Hydrolases; Phosphorus Isotopes; Polymers; Polynucleotides; Pseudomonas; RNA; Venoms | 1968 |
Metabolism of pyridinium precursors of pyridine nucleotides in perfused rat liver.
Topics: Animals; Carbon Dioxide; Carbon Isotopes; Carboxy-Lyases; Chromatography, Paper; Electrophoresis; Liver; Male; Models, Biological; NAD; Niacinamide; Nicotinic Acids; Perfusion; Pyridines; Rats; Ribose; Time Factors | 1968 |
One-electron reactions in biochemical systems as studied by pulse radiolysis. I. Nicotinamide-adenine dinucleotide and related compounds.
Topics: Adenine Nucleotides; Chemical Phenomena; Chemistry; Electron Transport; Free Radicals; Kinetics; NAD; Niacinamide; Oxidation-Reduction; Radiation Effects; Spectrophotometry | 1968 |
Vitamins, sugars and ethanol metabolism in man.
Topics: Adult; Alcohol Oxidoreductases; Ascorbic Acid; Ergocalciferols; Ethanol; Fructose; Galactose; Glucose; Humans; Male; Middle Aged; NAD; Niacinamide; Pyridoxine; Riboflavin; Sucrose; Thiamine; Vitamin A; Vitamin E | 1968 |
Site in cell-free protein synthesis sensitive to diphtheria toxin.
Topics: Amino Acids; Bacterial Proteins; Carbon Isotopes; Cell-Free System; Chromatography; Diphtheria Toxin; Electrophoresis, Disc; Enterococcus faecalis; Histocytochemistry; Liver; NAD; Niacinamide; Phenylalanine; Polynucleotides; Protein Biosynthesis; Ribosomes; Transferases | 1968 |
NAD-ase activity and glycolysis in Ehrlich-Lettre carcinoma and liver cell particulates.
Topics: Animals; Carcinoma, Ehrlich Tumor; Glycolysis; Liver; Mice; Mitochondria, Liver; NAD; Niacinamide; Nucleotidases; Rats | 1968 |
Inactivation of yeast alcohol dehydrogenase by N-alkylmaleimides.
Topics: Alcohol Oxidoreductases; Alkylation; Chemical Phenomena; Chemistry; Cysteine; Ethylmaleimide; Glutathione; Hydrogen-Ion Concentration; Imides; Kinetics; NAD; Niacinamide; Saccharomyces; Temperature | 1968 |
Evaluation of N1-(omega-bromoacetamidoalkyl)nicotinamides as inhibitors of dehydrogenases.
Topics: Adenine Nucleotides; Alcohol Oxidoreductases; Alkanes; Amides; Animals; Bromine; Electrophoresis; Glutamate Dehydrogenase; Horses; Kinetics; L-Lactate Dehydrogenase; Liver; Magnetic Resonance Spectroscopy; NAD; Niacinamide; Saccharomyces; Spectrophotometry; Swine | 1968 |
Enzymatic joining of polynucleotides, V. A DNA-adenylate intermediate in the polynucleotide-joining reaction.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Alkaline Phosphatase; Centrifugation, Density Gradient; Chromatography, Paper; Deoxyribonucleases; DNA; DNA, Viral; Electrophoresis; Escherichia coli; NAD; Niacinamide; Nucleosides; Nucleotidyltransferases; Phosphoric Monoester Hydrolases; Phosphorus Isotopes; Polynucleotides; Tritium; Venoms | 1968 |
[Contribution on the mechanism of corticosteroid hormone action on mitochondrial metabolism in rat brain and heart].
Topics: Amobarbital; Animals; Brain; Cytochromes; Depression, Chemical; Desoxycorticosterone; Electron Transport Complex IV; Glutathione; Hydrocortisone; Mitochondria; Mitochondria, Muscle; Myocardium; NAD; Niacinamide; Oxidoreductases; Rats | 1968 |
Studies on the biosynthesis of NAD by a direct method of tracing metabolism in vivo.
Topics: Animals; Carbon Isotopes; Liver; Mice; NAD; Niacinamide; Nicotinic Acids; Pyridines; Tryptophan | 1967 |
[The regulation of myocardial metabolism].
Topics: Adenosine Triphosphate; Animals; Anura; Denervation; Glucosyltransferases; Glycogen; Heart; Myocarditis; Myocardium; NAD; Niacinamide | 1966 |
Role of the liver in systemic puridine nucleotide metabolism.
Topics: Animals; Carbon Isotopes; Liver; Male; Mice; NAD; Niacinamide; Nicotinic Acids | 1968 |
Studies on the biosynthesis of nicotinamide adenine dinucleotide (NAD) in mammals and its regulatory mechanism. II.
Topics: Adenosine Triphosphate; Animals; Carbon Isotopes; Chromatography; Chromatography, Paper; Digestive System; Liver; Mice; NAD; Niacinamide; Nicotinic Acids; Pyridines; Radiometry; Tryptophan | 1967 |
The effect of deuterium oxide on the fluorescence of reduced nicotinamide adenine dinucleotide free in solution and in complexes with liver alcohol dehydrogenase.
Topics: Adenine Nucleotides; Alcohol Oxidoreductases; Deuterium; Fluorescence; Liver; NAD; Niacinamide; Phosphoric Monoester Hydrolases; Protein Binding; Pyridines; Spectrum Analysis; Water | 1969 |
Reversal of streptozotocin diabetes with nicotinamide.
Topics: Animals; Antibiotics, Antineoplastic; Blood Glucose; Diabetes Mellitus; Injections, Intraperitoneal; Injections, Intravenous; Male; NAD; Niacinamide; Nicotinic Acids | 1969 |
220 MHz proton magnetic resonance spectrum of NADH.
Topics: Alcohol Oxidoreductases; Deuterium; Hydroxysteroid Dehydrogenases; Magnetic Resonance Spectroscopy; NAD; Niacinamide; Oxidation-Reduction; Temperature | 1969 |
The ability of reduced nicotinamide mononucleotide to function as a hydrogen donor in the glutamic dehydrogenase reaction.
Topics: Ammonium Chloride; Chromatography, Paper; Glutamate Dehydrogenase; Hydrogen; Ketoglutaric Acids; Kinetics; Liver; NAD; Niacinamide; Nucleotides; Spectrophotometry; Spectrum Analysis; Ultraviolet Rays | 1969 |
Biosynthesis of squalene and cholesterol by cell-free extracts of adult rat brain.
Topics: Adenosine Triphosphate; Animals; Autoradiography; Brain; Carbon Isotopes; Cell-Free System; Cholestanes; Cholesterol; Chromatography, Ion Exchange; Chromatography, Thin Layer; Esters; Female; Glutathione; Hexosephosphates; Magnesium; Male; Mevalonic Acid; NAD; Niacinamide; Rats; Squalene; Sterols; Time Factors | 1969 |
[Protection against audiogenic crises in mice by nicotinamide].
Topics: Age Factors; Aminobutyrates; Animals; Coenzymes; Hearing Loss, Noise-Induced; Hydrazines; Mice; NAD; Niacinamide; Pyridoxal Phosphate | 1967 |
Pyridine coenzymes. VII. Catalysis of the hydration of the reduced form by iodoaromatic compounds.
Topics: Caseins; Catalysis; Chemical Phenomena; Chemistry; Coenzymes; Diiodotyrosine; Hydrogen-Ion Concentration; Iodine; Kinetics; Magnetic Resonance Spectroscopy; NAD; Niacinamide; Nucleotides; Phenols; Pyridines; Thyroglobulin; Thyroid Hormones; Thyronines | 1969 |
The pyridine nucleotide cycle.
Topics: Amidohydrolases; Animals; Carbon Isotopes; Diphosphates; Glycoside Hydrolases; Hypophysectomy; Liver; Mice; Models, Biological; Models, Chemical; N-Glycosyl Hydrolases; NAD; Niacinamide; Nicotinic Acids; Pyridines; Rats | 1966 |
1-methyl-1-nitrosourea depression of brain nicotinamide adenine dinucleotide in the production of neurologic toxicity.
Topics: Animals; Brain; Brain Chemistry; Injections, Intravenous; Male; Methods; Mice; N-Glycosyl Hydrolases; NAD; Neurologic Manifestations; Niacinamide; Nitroso Compounds; Urea | 1969 |
On the mechanism of the polynucleotide joining reaction.
Topics: Adenine Nucleotides; Binding Sites; Centrifugation, Density Gradient; Chromatography; Diphosphates; DNA, Bacterial; Electrophoresis; Electrophoresis, Disc; Escherichia coli; Ligases; NAD; Niacinamide; Nucleotides; Phosphorus Isotopes; Tritium | 1968 |
Survey of pyridine nucleotide metabolism in Tetrahymena pyriformis.
Topics: Amidohydrolases; Animals; Ligases; N-Glycosyl Hydrolases; NAD; Niacinamide; Nucleotides; Nucleotidyltransferases; Phosphoric Monoester Hydrolases; Phosphotransferases; Tetrahymena; Transferases | 1969 |
Factors affecting recombination of lactate dehydrogenase isoenzyme subunits.
Topics: Adenine Nucleotides; Dialysis; Electrophoresis; Freezing; Humans; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Liver; Myocardium; NAD; Niacinamide | 1968 |
The biosynthesis and degradation of nicotinamide-adenine dinucleotide during cick embryonic development.
Topics: Aging; Animals; Carbon Isotopes; Chick Embryo; N-Glycosyl Hydrolases; NAD; Niacinamide; Nicotinic Acids; Phosphoric Monoester Hydrolases; Tryptophan | 1969 |
A heat-stable nicotinamide adenine dinucleotidase from Pseudomonas fluorescens.
Topics: Hot Temperature; N-Glycosyl Hydrolases; NAD; Niacinamide; Pseudomonas; Ribose; Trypsin | 1969 |
1-methyl-1-nitrosourea and dialkylnitrosamine depression of nicotinamide adenine dinucleotide.
Topics: Animals; Depression, Chemical; Leukemia L1210; Liver; Male; N-Glycosyl Hydrolases; NAD; Niacinamide; Nitrosamines; Nitroso Compounds; Phosphoglucomutase; Rats; Urea | 1969 |
Synthesis of NAD and catabolism of nicotinic acid in the isolated perfused liver of normal and X-irradiated rat.
Topics: Animals; Carbon Isotopes; In Vitro Techniques; Kinetics; Liver; NAD; Niacinamide; Nicotinic Acids; Radiation Effects | 1969 |
Charge-transfer complexes in biological systems.
Topics: Absorption; Amino Acids; Chemical Phenomena; Chemistry; Energy Transfer; Enzymes; Models, Chemical; NAD; Niacinamide; Pyridinium Compounds; Spectrophotometry; Spectrum Analysis | 1969 |
Reduced 1,6-dihydrodiphosphopyridine nucleotide. Chemical properties and enzymatic modification.
Topics: Barium; Carbon Isotopes; Cellulose; Charcoal; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, Ion Exchange; Drug Stability; Glyceraldehyde; Hexosephosphates; Hot Temperature; Hydrogen-Ion Concentration; Models, Chemical; NAD; Niacinamide; Nucleotides; Phosphates; Phosphoric Monoester Hydrolases; Phosphorus Isotopes; Saccharomyces; Spectrophotometry; Trioses | 1969 |
Studies on the ability of compounds to block the diabetogenic activity of streptozotocin.
Topics: Amino Acids; Animals; Diabetes Mellitus; Diaphragm; Diazoxide; Epinephrine; Ethanol; Glucosamine; Glucose; Hyperglycemia; Hypoglycemic Agents; Male; NAD; Niacinamide; Nitroso Compounds; Pyrazinamide; Pyrazines; Pyrazoles; Rats; Tolbutamide | 1969 |
[Kinetic investigation on the enzymatic hydroxylation of phenazone, oxidative O-demethylation of codeine and N-demethylation of aminophenazone by rat liver microsomes].
Topics: Aminopyrine; Animals; Antipyrine; Buffers; Codeine; Drug Storage; Glucose; Hexosephosphates; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Male; Microsomes; NAD; Niacinamide; Rats; Temperature; Time Factors | 1969 |
Studies on polymer of adenosine diphosphate ribose. VI. Radioautographic demonstration of incorporation of NAD into nuclear macromolecule.
Topics: Adenine Nucleotides; Animals; Autoradiography; Cell Nucleus; Culture Techniques; Histones; Macromolecular Substances; NAD; Niacinamide; Rats; Ribose | 1969 |
Potential coenzyme inhibitors. 3. Some reactions of substituted nicotinamide and dihydronicotinamide derivatives.
Topics: Chemical Phenomena; Chemistry; Cyanides; Kinetics; NAD; Niacinamide; Oxidation-Reduction; Spectrum Analysis; Ultraviolet Rays | 1969 |
[Metabolism of nicotinamide coenzymes following total-body irradiation. I. Catabolism of NAD and excretion of its metabolites].
Topics: Animals; Carbon Isotopes; Intestinal Mucosa; Liver; Male; Muscles; NAD; Niacinamide; Nicotinic Acids; Pyridones; Radiation Effects; Rats; Spleen; Starvation; Testis | 1969 |
Nicotinate, quinolinate and nicotinamide as precursors in the biosynthesis of nicotinamide-adenine dinucleotide in barley.
Topics: Ascomycota; Carbon Isotopes; Chromatography; Edible Grain; NAD; Niacinamide; Nicotinic Acids; Plant Diseases; Plants; Pyridines | 1969 |
Tryptophan and nitrogen metabolism and pregnancy of the rat as affected by dietary supplementations with leucine and with amino acid mixtures.
Topics: Amino Acids; Animals; Deficiency Diseases; Diet; Dietary Proteins; Feces; Female; Fetal Death; Fetus; Isoleucine; Kidney; Leucine; Liver; Male; Maternal-Fetal Exchange; NAD; Niacinamide; Nicotinic Acids; Nitrogen; Pregnancy; Pregnancy, Animal; Rats; Tryptophan; Valine | 1970 |
Effect of hyperphysiological levels of hexestrol on the hepatic metabolism of nicotinate in the mouse.
Topics: Animals; Carbon Isotopes; Hexestrol; Injections, Intravenous; Liver; Male; Mice; NAD; Niacinamide; Nicotinic Acids | 1970 |
Evidence for a functional pyridine nucleotide cycle in Escherichia coli.
Topics: Escherichia coli; NAD; Niacinamide; Nicotinic Acids | 1969 |
NAD biosynthesis in rabbit erythrocytes and reticulocytes after whole-body x-irradiation.
Topics: Animals; Erythrocytes; Glucose; Glutamine; Hexokinase; Magnesium; Methylene Blue; NAD; Niacinamide; Nicotinic Acids; Nucleosides; Oxidation-Reduction; Rabbits; Radiation Effects; Reticulocytes | 1969 |
Effect of hormones on the biosynthesis of nicotinic acid from tryptophan in man.
Topics: Carboxy-Lyases; Chlorotrianisene; Chromatography, Ion Exchange; Diethylstilbestrol; Humans; Hydrocortisone; Male; NAD; Niacinamide; Nicotinic Acids; Picolinic Acids; Progestins; Prostatic Neoplasms; Pyridones; Tryptophan | 1970 |
Effect of cord factor on carbohydrate metabolism in mice.
Topics: Animals; Antitoxins; Carbohydrate Metabolism; Carbon Isotopes; Fructose-Bisphosphatase; Glucose; Glucosephosphate Dehydrogenase; Glucosyltransferases; Glycogen; Glycolipids; Hexokinase; Lactates; Liver; Liver Glycogen; Mice; Muscles; Mycobacterium tuberculosis; N-Glycosyl Hydrolases; NAD; Niacinamide; Oxidoreductases; Proteins; Pyruvates; Toxins, Biological | 1970 |
Hereditary methemoglobinemia, toxic methemoglobinemia and the reduction of methemoglobin.
Topics: Erythrocytes; Glucose; Glutathione; Hemoglobins; Heterozygote; Homozygote; Humans; Lactates; Methemoglobin; Methemoglobinemia; NAD; Niacinamide; Nicotinic Acids; Nitrites; Nucleotides; Oxidation-Reduction; Postural Balance; Pyridines; Pyruvates; Ribose; Time Factors | 1968 |
Accumulation of oxidized diphosphopyridine nucleotide in mouse liver after administration of reduced diphosphopyridine nucleotide.
Topics: Animals; Carbon Isotopes; Chromatography, Paper; Injections, Intraperitoneal; Liver; Male; Mice; NAD; Niacinamide; Oxidation-Reduction; Phosphorus Isotopes; Time Factors; Tritium; Ultraviolet Rays | 1970 |
Substituent effects on pyridinium ring-opening reactions. Facile ring opening of 1-(N,N-dimethylcarbamoyl)nicotinamide cation.
Topics: Buffers; Carbamates; Chemical Phenomena; Chemistry; Fluorescence; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; NAD; Niacinamide; Spectrophotometry; Ultraviolet Rays | 1970 |
Uptake and metabolism of nicotinic acid by human blood platelets. Effects of structure analogs and metabolic inhibitors.
Topics: Blood Platelets; Carbon Isotopes; Cyanides; Dinitrophenols; Fluorides; Humans; Iodoacetates; Kinetics; NAD; Niacinamide; Nicotinic Acids; Salicylates | 1970 |
NAD biosynthesis in polymorphonuclear leucocytes of guinea-pigs. I. Nicotinic acid pathway of NAD synthesis in cell-free preparations.
Topics: Animals; Carbon Isotopes; Cell-Free System; Depression, Chemical; Guinea Pigs; In Vitro Techniques; Leukocytes; Ligases; N-Glycosyl Hydrolases; NAD; Niacinamide; Nicotinic Acids; Nucleotidyltransferases; Transferases | 1970 |
A proposed mechanism for ADP ribosylation of aminoacyl transferase II by diphtheria toxin.
Topics: Acyltransferases; Adenine Nucleotides; Amino Acids; Animals; Binding Sites; Chemical Precipitation; Diphtheria Toxin; Hot Temperature; Liver; Models, Biological; Models, Chemical; NAD; Niacinamide; Rats; Trichloroacetic Acid; Tritium | 1969 |
[Changes in the activity of liver NADase in rats after administration of nicotinic acid, 3-methylpyridine and nicotinamide in excess].
Topics: Animals; Liver; N-Glycosyl Hydrolases; NAD; Niacinamide; Nicotinic Acids; Pyridines; Rats | 1968 |
Studies of FAD and NADH in the presence of N1-dodecyl-nicotinamide chloride micelles.
Topics: Chemical Phenomena; Chemistry; Chlorides; Detergents; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Fluorometry; NAD; Niacinamide; Osmolar Concentration; Spectrophotometry; Sulfuric Acids; Viscosity | 1970 |
Metabolism of labeled nicotinamide coenzyme in different organs of mice and rats.
Topics: Animals; Brain; Carbon Isotopes; Intestine, Small; Kidney; Liver; Male; Mice; Muscles; NAD; Niacinamide; Nicotinic Acids; Rats; Species Specificity; Spleen; Testis | 1970 |
[Nicotinamide-2',3'-dideoxyribofuranosyl-adenine-pyrophosphate].
Topics: Adenine Nucleotides; NAD; Niacinamide; Spectrum Analysis | 1970 |
Nicotinamide deficiency and thalidomide: potential teratogenic disturbances in Long-Evans rats.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Animal Feed; Animals; Birth Weight; Chlorpromazine; Congenital Abnormalities; Deficiency Diseases; Female; Fertility; Fetal Death; Fetal Diseases; Gestational Age; Liver; NAD; Niacinamide; Pregnancy; Pregnancy Complications; Rats; Rodent Diseases; Species Specificity; Thalidomide | 1969 |
Tissue NAD levels and the response to irradiation of cytotoxic drugs.
Topics: Animals; beta-Aminoethyl Isothiourea; Cysteamine; Female; Lymphoma; Male; Mechlorethamine; Mice; NAD; Neoplasms, Experimental; Niacinamide; Nicotinic Acids; Pyridines; Radiation Effects; Radiation-Protective Agents; Radiation-Sensitizing Agents; Sarcoma 180; Serotonin | 1970 |
Alkylation studies on a reactive histidine in pig heart malate dehydrogenase.
Topics: Adenine Nucleotides; Alkylation; Animals; Bromine; Histidine; Hydrogen-Ion Concentration; Iodoacetates; Kinetics; Malate Dehydrogenase; Malates; Mitochondria, Muscle; Myocardium; NAD; Niacinamide; Oxaloacetates; Propionates; Swine | 1970 |
Tetrahydropapaveroline: an alkaloid metabolite of dopamine in vitro.
Topics: Alkaloids; Animals; Benzene Derivatives; Brain; Brain Stem; Carbon Isotopes; Chromatography, Gas; Chromatography, Thin Layer; Dopamine; In Vitro Techniques; Liver; Male; NAD; Niacinamide; Papaverine; Protein Binding; Quinolines; Rats; Semicarbazides; Spectrophotometry; Tissue Extracts | 1970 |
Binding and kinetic studies of liver alcohol dehydrogenase-coenzyme-pyrazole complexes.
Topics: Alcohol Oxidoreductases; Animals; Chemical Phenomena; Chemistry; Coenzymes; Horses; Hypoxanthines; Kinetics; Liver; NAD; Niacinamide; Nucleotides; Protein Binding; Pyrazoles; Spectrophotometry | 1970 |
Effects of N1-alkylnicotinamide chlorides on NADH oxidation in rat liver submitochondrial particles.
Topics: Adenine Nucleotides; Animals; Electron Transport; Ferricyanides; In Vitro Techniques; Mitochondria, Liver; NAD; Niacinamide; Pyridines; Rats; Succinates | 1970 |
Interaction of lactate dehydrogenase with its coenzyme, nicotinamide-adenine dinucleotide.
Topics: Adenine Nucleotides; Animals; Crystallography; Kinetics; L-Lactate Dehydrogenase; NAD; Niacinamide; Protein Binding; Sharks; X-Ray Diffraction | 1970 |
Use of isotope competition and alternative substrates for studying the kinetic mechanism of enzyme action. I. Experiments with hexokinase and alcohol dehydroeenase.
Topics: Alcohol Oxidoreductases; Animals; Carbon Isotopes; Fructose; Hexokinase; Horses; Kinetics; Liver; NAD; Niacinamide; Saccharomyces; Sulfur | 1970 |
The effect of raising the NAD+ content on the pathways of carbohydrate metabolism and lipogenesis in rat liver.
Topics: Adenine Nucleotides; Animals; Carbohydrate Metabolism; Carbon Dioxide; Carbon Isotopes; Citrates; Citric Acid Cycle; Coenzyme A; Fatty Acids; Glucose; Glycerophosphates; Hexokinase; Hexosephosphates; Kinetics; Lactates; Lipids; Liver; Malates; Metabolism; Mitochondria, Liver; NAD; Niacinamide; Phosphofructokinase-1; Phosphoglycerate Kinase; Pyruvate Kinase; Rats; Time Factors | 1970 |
NAD biosynthesis in polymorphonuclear leucocytes of guinea pigs. Comparative studies on different NAD precursors in intact cells.
Topics: Animals; Carbon Isotopes; Cell-Free System; Guinea Pigs; Leukocytes; NAD; Niacinamide; Nicotinic Acids; Nucleotides; Pyridines; Tryptophan | 1970 |
Increase of NAD glycohydrolase activity and decrease of NAD concentration in rat liver during fasting.
Topics: Animals; Fasting; Injections, Intraperitoneal; Liver; Male; N-Glycosyl Hydrolases; NAD; Niacinamide; Rats | 1970 |
[Assignment of an essential histidine residue to the substrate binding site of lactate dehydrogenase].
Topics: Amino Acid Sequence; Animals; Binding Sites; Carbon Isotopes; Histidine; Kinetics; L-Lactate Dehydrogenase; Myocardium; NAD; Niacinamide; Nucleotides; Pyruvates; Swine | 1971 |
Excitation transfer in complexes of horse liver alcohol dehydrogenase.
Topics: Adenine Nucleotides; Alcohol Oxidoreductases; Amides; Animals; Butyrates; Energy Transfer; Fluorescence; Fluorometry; Horses; Kinetics; Liver; NAD; Niacinamide; Nucleotides; Phenanthrolines; Protein Binding; Pyrazoles; Spectrophotometry; Thyroxine | 1971 |
[Studies on the metabolism of nicotinamide coenzymes after whole body irradiation. 3. Synthesis of NAD and its precursors in isolated perfused liver].
Topics: Animals; Coenzymes; Enzyme Precursors; In Vitro Techniques; Liver; NAD; Niacinamide; Nicotinic Acids; Radiation Effects; Radioisotopes; Radiometry; Rats | 1970 |
Nicotinamide HCl and thyroid radioiodine metabolism in mice: effects due to acid.
Topics: Animals; Diiodotyrosine; Female; Hydrochloric Acid; Hydrogen-Ion Concentration; Iodine; Iodine Isotopes; Isoniazid; Long-Acting Thyroid Stimulator; Mice; Monoiodotyrosine; NAD; Niacinamide; Nicotinic Acids; Pyridines; Sodium Hydroxide; Stimulation, Chemical; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 1971 |
A functional role of polyADPR in DNA synthesis.
Topics: Adenine Nucleotides; Animals; Cattle; Cell Nucleus; Chromosomes; DNA; DNA Nucleotidyltransferases; In Vitro Techniques; Liver; Magnesium; NAD; Niacinamide; Polynucleotides; Rats; Ribose; Temperature; Templates, Genetic; Thymine Nucleotides; Thymus Gland; Time Factors; Tritium | 1970 |
Terminal oxidations in Bacillus brevis ATCC 10068. I. The measurement of the NADH oxidase activity of Bacillus brevis ATCC 10068.
Topics: Bacillus; Fluorides; NAD; Niacinamide; Nucleosides; Oxidoreductases; Phosphates; Polarography; Spectrophotometry | 1970 |
[NAD permeation into the liver cell].
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Carbon Isotopes; Cell Membrane Permeability; Female; Liver; NAD; Niacinamide; Perfusion; Rats | 1971 |
Metabolism of calcium and effect of divalent cations on respiratory activity of yeast mitochondria.
Topics: Adenosine Triphosphate; Calcium; Citrates; Magnesium; Methods; Mitochondria; Mitosporic Fungi; NAD; Niacinamide; Oxidation-Reduction; Oxygen Consumption; Polarography; Saccharomyces; Temperature | 1970 |
Inhibition of nuclear NAD nucleosidase and poly ADP-ribose polymerase activity from rat liver by nicotinamide and 5'-methyl nicotinamide.
Topics: Adenine Nucleotides; Animals; Carbon Isotopes; Cell Nucleus; DNA; Female; Kinetics; Liver; N-Glycosyl Hydrolases; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Nucleotidyltransferases; Rats; Ribose | 1971 |
Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin.
Topics: Acyltransferases; Adenine Nucleotides; Animals; Calcium Phosphates; Carbon Isotopes; Chromatography; Chromatography, Ion Exchange; Chromatography, Paper; Diphtheria Antitoxin; Diphtheria Toxin; Diphtheria Toxoid; Electrophoresis; Electrophoresis, Disc; Hydrogen-Ion Concentration; Hydroxyapatites; Iodine Isotopes; Isoelectric Focusing; Kinetics; Liver; Methods; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Phenylalanine; Phosphorus Isotopes; Protein Biosynthesis; Rats; Ribose; Ribosomes | 1971 |
Inhibition of nicotinamidase by nicotinamide adenine dinucleotide.
Topics: Acetylesterase; Adenine Nucleotides; Amidohydrolases; Animals; Bacillus; Chloromercuribenzoates; Chromatography; Chromatography, DEAE-Cellulose; Clostridium; Escherichia coli; Fatty Acids; Feedback; Hydrogen-Ion Concentration; Hydroxyapatites; Kinetics; Micrococcus; Microsomes, Liver; Molecular Weight; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Nucleotides; Pentosephosphates; Pyridines; Rabbits; Saccharomyces; Species Specificity; Thyroxine; Time Factors; Urea | 1971 |
Hormonal alteration of efficiency of conversion of tryptophan to urinary metabolites of niacin in man.
Topics: Chlorotrianisene; Contraceptives, Oral; Depression, Chemical; Diethylstilbestrol; Humans; Hydrocortisone; Male; NAD; Niacinamide; Nicotinic Acids; Norethynodrel; Prostatic Diseases; Pyridones; Stimulation, Chemical; Tryptophan | 1971 |
[Pyridine nucleotides. I. Nicotinamide mononucleotide deamidase and a new pathway for "salvage synthesis" of nicotinamide adenine dinucleotide].
Topics: Amidohydrolases; Chromatography, Paper; Electrophoresis; NAD; Niacinamide; Nucleotides; Paper | 1971 |
Some properties of reactions catalyzed by pig brain NAD glycohydrolase.
Topics: Acetone; Alcohols; Animals; Brain; Catalysis; Chemical Phenomena; Chemistry; Deuterium; Enzyme Activation; Hydrogen-Ion Concentration; Kinetics; N-Glycosyl Hydrolases; NAD; Niacinamide; Nucleosides; Osmolar Concentration; Sulfhydryl Reagents; Sulfur; Swine | 1971 |
Interaction of nicotinamide-adenine dinucleotide and its analogs with glyceraldehyde 3-phosphate dehydrogenase.
Topics: Adenine Nucleotides; Animals; Binding Sites; Charcoal; Dialysis; Drug Stability; Glyceraldehyde-3-Phosphate Dehydrogenases; Hot Temperature; Kinetics; Models, Chemical; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Nucleotides; Protein Binding; Pyridines; Rabbits; Ribose; Spectrophotometry; Sulfur; Ultraviolet Rays | 1971 |
Relation of the auramine O binding site to the active site of horse liver alcohol dehydrogenase.
Topics: Adenine Nucleotides; Alcohol Oxidoreductases; Alcohols; Amides; Aniline Compounds; Animals; Benzyl Compounds; Binding Sites; Butyrates; Coloring Agents; Cyclohexanes; Dialysis; Ethanol; Fluorometry; Horses; Imines; Kinetics; Liver; Models, Chemical; Models, Structural; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Potassium Chloride; Pyrazoles; Ribose | 1971 |
[Induction and prevention of developmental abnormalities in rabbits by administration of 6-aminonicotinic acid and nicotinic acid amide].
Topics: Abnormalities, Drug-Induced; Amines; Animals; Female; Fetus; Gestational Age; Microphthalmos; Mouth Abnormalities; Musculoskeletal Abnormalities; NAD; Niacinamide; Pregnancy; Pregnancy, Animal; Rabbits | 1971 |
Autoxidation of reduced pyridine coenzymes and of their models promoted by N,N,N',N'-tetramethyl-p-phenylenediamine.
Topics: Aniline Compounds; Benzyl Compounds; Catalysis; Deuterium; Free Radicals; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Manometry; Mathematics; Methanol; NAD; Niacinamide; Oxidation-Reduction; Oxygen; Oxygen Consumption; Potentiometry; Pyridinium Compounds; Spectrophotometry; Thermodynamics; Tromethamine | 1971 |
Effect of streptozotocin on glucose-induced insulin secretion by isolated islets of Langerhans.
Topics: Animals; Antineoplastic Agents; Diabetes Mellitus; Glucose; In Vitro Techniques; Insulin; Insulin Antagonists; Islets of Langerhans; Male; NAD; Niacinamide; Nicotinic Acids; Nitroso Compounds; Nitrosourea Compounds; Rats; Rhamnose; Urea | 1971 |
Interaction of ADP-ribosylated aminoacyl-transferase II with GTP and with ribosomes.
Topics: Acyltransferases; Adenine Nucleotides; Adenosine Diphosphate; Animals; Binding Sites; Carbon Isotopes; Centrifugation, Density Gradient; Depression, Chemical; Dialysis; Diphtheria Toxin; Guanine Nucleotides; Hydrogen-Ion Concentration; Isoelectric Focusing; Leucine; Liver; Mathematics; NAD; Niacinamide; Rats; Ribose; Ribosomes; RNA, Transfer; Solubility; Tritium | 1971 |
Effects of streptozotocin on carbohydrate and lipid metabolism in the rat.
Topics: Acetoacetates; Animals; Antibiotics, Antineoplastic; Blood Glucose; Carbamates; Diabetes Mellitus; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Glucosamine; Glucose; Glyceric Acids; Hydroxybutyrates; Hyperglycemia; Hypolipidemic Agents; Ketoglutaric Acids; Ketone Bodies; Lactates; Lipid Metabolism; Liver; Liver Glycogen; Male; NAD; Niacinamide; Nitroso Compounds; Pyrazoles; Pyruvates; Rats; Triglycerides | 1971 |
Activity of polyadenosine diphosphoribose polymerase during the human cell cycle.
Topics: Adenosine Diphosphate; Cell Division; Cell Fractionation; Cell Nucleus; Culture Techniques; Cyclic AMP; Deoxyribonucleases; Depression, Chemical; DNA, Neoplasm; HeLa Cells; Humans; NAD; Neoplasm Proteins; Niacinamide; Nucleoside Diphosphate Sugars; Nucleotidyltransferases; Polynucleotides; RNA Nucleotidyltransferases; RNA, Neoplasm; Thymidine; Time Factors; Tritium; Uridine | 1971 |
Nicotinamide mononucleotide. Determination of its enzymatic formation in vitro and its physiological rôle for the biosynthesis of nicotinamide-adenine dinucleotide in mice.
Topics: Adenosine Triphosphate; Animals; Autoradiography; Brain; Carbon Isotopes; Female; Kidney; Liver; Magnesium; Mice; Myocardium; NAD; Niacinamide; Nicotinic Acids; Nucleotides; Pentosephosphates; Phosphoric Acids; Ribose; Spleen; Transferases | 1971 |
Nicotinamide adenine dinucleotide in developing chick embryo.
Topics: Aging; Alcohol Oxidoreductases; Animals; Chick Embryo; Egg White; Egg Yolk; Female; Hydrogen-Ion Concentration; Liver; NAD; Niacinamide; Nicotinic Acids; Ovalbumin; Pyridines; Tryptophan | 1971 |
Interaction between adenine nucleotides and 3-phosphoglyceraldehyde dehydrogenase. I. Inhibition of the hydrolysis of S-acetyl-enzyme intermediate in the esterase activity.
Topics: Acetates; Acylation; Adenine Nucleotides; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Chemical Phenomena; Chemistry; Cyclic AMP; Depression, Chemical; Diphosphates; Enzyme Activation; Glyceraldehyde-3-Phosphate Dehydrogenases; Guanine Nucleotides; Guanosine Triphosphate; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Light; Models, Biological; Muscles; NAD; Niacinamide; Nitrophenols; Nucleoside Diphosphate Sugars; Rabbits; Radiation Effects; Ribose; Spectrophotometry; Stimulation, Chemical | 1971 |
Interaction between adenine nucleotides and 3-phosphoglyceraldehyde dehydrogenase. II. A study of the mechanism of catalysis and metabolic control of the multi-functional enzyme.
Topics: Acetates; Acylation; Adenine Nucleotides; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Arsenic; Autoradiography; Binding Sites; Carbon Isotopes; Catalysis; Chemical Phenomena; Chemistry; Cyclic AMP; Depression, Chemical; Diphosphates; Electrophoresis; Enzyme Activation; Glyceraldehyde-3-Phosphate Dehydrogenases; Guanine Nucleotides; Hydrogen-Ion Concentration; Hydrolysis; Muscles; NAD; Niacinamide; Nitrophenols; Nucleoside Diphosphate Sugars; Pepsin A; Peptides; Phosphoric Acids; Protein Binding; Rabbits; Ribose; Stimulation, Chemical | 1971 |
Isolation and characterization of the fluorescent alkali product from diphosphopyridine nucleotide.
Topics: Fluorescence; Hydrogen-Ion Concentration; Infrared Rays; Magnetic Resonance Spectroscopy; Mass Spectrometry; NAD; Niacinamide; Pyridines; Sodium Hydroxide; Spectrophotometry; Ultraviolet Rays | 1971 |
Studies on the biosynthesis of NAD from nicotinamide and on the intracellular pyridine nucleotide cycle in isolated perfused rat liver.
Topics: Anaerobiosis; Animals; Azaserine; Bile; Carbon Isotopes; Female; Liver; N-Glycosyl Hydrolases; NAD; Niacinamide; Nicotinic Acids; Nucleotides; Perfusion; Pyridines; Rats | 1971 |
Nicotinamide deamidation by microorganisms in rat stomach.
Topics: Aminohydrolases; Animals; Bacteriological Techniques; Carbon Isotopes; Chromatography, Paper; Enterococcus faecalis; Escherichia coli; Flavobacterium; Gastric Mucosa; Hydrogen-Ion Concentration; Lactobacillus acidophilus; Male; NAD; Niacinamide; Nicotinic Acids; Rats; Rats, Inbred Strains; Stomach | 1971 |
Effect of diazooxonorleucine and N-ethyl maleimide on the incorporation of nicotinic acid and nicotinamide into the pyridine nucleotides of human erythrocytes in vitro.
Topics: Adult; Amidohydrolases; Anemia, Hemolytic, Congenital Nonspherocytic; Anti-Bacterial Agents; Azo Compounds; Carbon Isotopes; Chromatography, Paper; Diazooxonorleucine; Erythrocytes; Ethylmaleimide; Glycolysis; Humans; NAD; Niacinamide; Nicotinic Acids; Nucleotides; Phospholipids; Pyridines | 1970 |
[Specific incorporation of the coenzyme analogue nicotinamide-(5-(bromoacetyl)-4-methyl-imidazole)-dinucleotide into alcohol dehydrogenase from liver].
Topics: Acetaldehyde; Alcohol Oxidoreductases; Animals; Chemical Phenomena; Chemistry; Ethanol; Hydrolysis; Imidazoles; Liver; N-Glycosyl Hydrolases; NAD; Niacinamide; Swine | 1971 |
Control of heme biosynthesis. Effect of nicotinamide adenine dinucleotide on the induction of -aminolevulinate synthetase.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Acyltransferases; Allyl Compounds; Amino Acids; Animals; Carbon Isotopes; Female; Glycine; Heme; Levulinic Acids; Liver; Mice; Models, Biological; NAD; Niacinamide; Succinates | 1970 |
Bull semen nicotinamide adenine dinucleotide nucleosidase. 3. Properties of the substrate binding site.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Alkylation; Animals; Binding Sites; Cattle; Hydrogen-Ion Concentration; Kinetics; Male; Mathematics; N-Glycosyl Hydrolases; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Protein Binding; Ribose; Semen; Structure-Activity Relationship | 1972 |
Method for isolating mutants overproducing nicotinamide adenine dinucleotide and its precursors.
Topics: Bacteriological Techniques; Carbon Isotopes; Cell-Free System; Chromatography; Culture Media; Electrophoresis; Escherichia coli; Filtration; Genetics, Microbial; Haemophilus; Methods; Mutagens; Mutation; NAD; Niacinamide; Nicotinic Acids; Nitrosoguanidines; Pyrimidine Nucleotides; Temperature | 1972 |
The management of nicotinamide and nicotinic acid in the mouse.
Topics: Animals; Brain; Carbon Isotopes; Chromatography, Paper; Female; Intestinal Absorption; Intestinal Mucosa; Kidney; Kinetics; Liver; Lung; Mice; Muscles; Myocardium; NAD; Niacinamide; Nicotinic Acids; Organ Specificity; Ovary; Spleen | 1972 |
Studies on the structure and mechanism of action of the malate-lactate transhydrogenase.
Topics: Amino Acids; Borohydrides; Carbon Isotopes; Centrifugation, Density Gradient; Chromatography; Chromatography, Gel; Fluorometry; Kinetics; L-Lactate Dehydrogenase; Macromolecular Substances; Malate Dehydrogenase; Micrococcus; Models, Chemical; Molecular Weight; N-Glycosyl Hydrolases; NAD; Niacinamide; Protein Binding; Protein Denaturation; Pyruvates; Tritium; Urea; Zinc; Zinc Isotopes | 1972 |
In vitro metabolism of 15 -hydroxyprogesterone by rabbit liver.
Topics: Animals; Chemical Phenomena; Chemistry; Chromatography, Gel; Female; Humans; Hydroxycorticosteroids; Hydroxyprogesterones; Infrared Rays; Ketosteroids; Liver; Male; Mixed Function Oxygenases; NAD; Niacinamide; Oxidation-Reduction; Pregnanes; Progesterone; Rabbits; Species Specificity; Spectrophotometry; Steroids; Tritium | 1972 |
Studies on nicotinamide deamidation in rat stomach.
Topics: Animals; Carbon Isotopes; Gastric Mucosa; Lyases; Male; NAD; Niacinamide; Nicotinic Acids; Rats | 1971 |
Comparative metabolism of nicotinamide and nicotinic acid in mice.
Topics: Animals; Carbon Isotopes; Intestinal Absorption; Mice; NAD; Niacinamide; Nicotinic Acids | 1971 |
Convenient method for enzymic synthesis of 14 C-nicotinamide riboside.
Topics: Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Paper; Drug Stability; Hot Temperature; Isotope Labeling; Methods; NAD; Niacinamide; Nucleosides; Nucleotidases; Phosphoric Monoester Hydrolases; Proteus; Proteus vulgaris; Ribonucleosides; Spectrophotometry; Ultraviolet Rays | 1972 |
Metabolism of nicotinamide adenine dinucleotide in human and bovine strainsof Mycobacterium tuberculosis.
Topics: Amidohydrolases; Animals; Carbon Isotopes; Cattle; Cell-Free System; Chromatography, Paper; Humans; Mycobacterium bovis; Mycobacterium tuberculosis; N-Glycosyl Hydrolases; NAD; Niacinamide; Nicotinic Acids; Nucleotides; Pentosyltransferases; Species Specificity | 1972 |
Some effects of environment on the folding of nicotinamide-adenine dinucleotides in aqueous solutions.
Topics: Adenosine Monophosphate; Chemical Phenomena; Chemistry; Deuterium; Magnetic Resonance Spectroscopy; Mathematics; Methanol; NAD; Niacinamide; Oxidation-Reduction; Ribonucleotides; Silicon; Statistics as Topic; Sulfonic Acids; Temperature; Thermodynamics; Urea; Water | 1972 |
Photooxidation of adenine and its nucleotides in the presence of riboflavin. IV. Photochemical reaction and photoproducts of NAD.
Topics: Adenine; Alcohol Oxidoreductases; Chromatography, Ion Exchange; Chromatography, Paper; Light; Magnetic Resonance Spectroscopy; Mass Spectrometry; NAD; Niacinamide; Nucleotides; Oxidation-Reduction; Periodic Acid; Phosphoric Monoester Hydrolases; Photochemistry; Riboflavin; Spectrum Analysis; Ultraviolet Rays | 1972 |
Inactivation of yeast alcohol dehydrogenase by dehydroascorbic acid and D-arabinosone.
Topics: Adenine; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Alcohol Oxidoreductases; Arabinose; Ascorbic Acid; Chloromercuribenzoates; Depression, Chemical; Glutathione; Ketones; Mercaptoethanol; NAD; Niacinamide; Ozone; Saccharomyces | 1972 |
Poly (adenosine diphosphate ribose) synthesis in soluble extracts of animal organs.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Animals; Bone Marrow; Deoxyribonucleases; DNA; Liver; Lymph Nodes; NAD; Niacinamide; Nucleic Acid Denaturation; Nucleoside Diphosphate Sugars; Phosphorus Isotopes; Polynucleotides; Rabbits; Rats; Ribose; Spleen; Temperature; Thymus Gland; Time Factors | 1972 |
[Glycolysis in different fractions of chick brain tissue during embryonic development].
Topics: Adenosine Triphosphate; Animals; Brain; Chick Embryo; Glucose; Glycolysis; Ketoglutaric Acids; Lactates; Mitochondria; NAD; Niacinamide; Oxygen Consumption; Pyruvates | 1970 |
The pyridine nucleotide cycle: presence of a nicotinamide mononucleotide-specific glycohydrolase in Escherichia coli.
Topics: Cell Membrane; Cell-Free System; Cytoplasm; Escherichia coli; Glycoside Hydrolases; NAD; Niacinamide; Polynucleotide Ligases | 1972 |
Studies on deoxyribonucleic acid synthesis in uteri of immature mouse.
Topics: Animals; Cell Nucleus; Chromatin; DNA; Estradiol; Estrogen Antagonists; Female; Liver; Mice; NAD; Niacinamide; Nucleotidyltransferases; Organ Size; Stimulation, Chemical; Thymidine; Tritium; Uterus | 1972 |
Pyridine nucleotide synthesis. Purification of nicotinamide mononucleotide pyrophosphorylase from rat erythrocytes.
Topics: Adenosine Triphosphate; Ammonium Sulfate; Animals; Carbon Isotopes; Chromatography, DEAE-Cellulose; Drug Stability; Edetic Acid; Erythrocytes; Hemolysis; Hydrogen-Ion Concentration; Kinetics; Magnesium; N-Glycosyl Hydrolases; NAD; Niacinamide; Nicotinamide Mononucleotide; Nicotinic Acids; Nucleotidyltransferases; Pentosephosphates; Phosphoric Acids; Rats | 1972 |
Pyridinium precursors of pyridine nucleotides in perfused rat kidney and in the testis.
Topics: Adenosine Triphosphate; Amidohydrolases; Animals; Carbon Isotopes; Kidney; Male; N-Glycosyl Hydrolases; NAD; Niacinamide; Nicotinamide Mononucleotide; Nicotinic Acids; Nucleotidyltransferases; Perfusion; Pyridines; Pyridinium Compounds; Rats; Testis; Uric Acid | 1972 |
Electron spin resonance study of radicals produced by one-electron reduction of pyridines.
Topics: Electron Spin Resonance Spectroscopy; Free Radicals; Hydrogen-Ion Concentration; Isonicotinic Acids; NAD; Niacinamide; Pyridines; Pyridinium Compounds; Radiation Effects | 1972 |
Abnormal tryptophan metabolism in patients with scurvy-type skin.
Topics: Acetates; Adult; Aminohippuric Acids; Black or African American; Black People; Ethnicity; Glucuronates; Hemosiderosis; Humans; Indoles; Kynurenic Acid; Kynurenine; Male; NAD; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Pyridines; Scurvy; South Africa; Sulfuric Acids; Tryptophan; Xanthurenates | 1973 |
The elongation factor 2 content of mammalian cells. Assay method and relation to ribosome number.
Topics: Adenine Nucleotides; Animals; Centrifugation, Density Gradient; Charcoal; Diphtheria Toxin; Histamine; Methods; NAD; Niacinamide; Peptide Elongation Factors; Phosphorus Isotopes; Polynucleotides; Rabbits; Reticulocytes; Ribose; Ribosomes; RNA; RNA, Transfer; Solubility | 1973 |
Accelerated turnover rate of nicotinamide-adenine dinucleotides in the liver of rats intoxicated with carbon disulphide.
Topics: Amidohydrolases; Animals; Carbon Disulfide; Carbon Isotopes; Female; Kinetics; Liver; NAD; Niacinamide; Proteins; Rats; Time Factors | 1972 |
Metabolism of pyridine nucleotides and its relation to DNA synthesis in regenerating mouse liver.
Topics: Adenine Nucleotides; Animals; DNA; Female; Hepatectomy; Hydrolases; Kynurenine; Liver; Liver Regeneration; Mice; Mice, Inbred Strains; NAD; Niacinamide; Nicotinamide Mononucleotide; Nucleotidyltransferases; ortho-Aminobenzoates; Pentosyltransferases; Transaminases; Tryptophan | 1972 |
Influence of niacinamide administration on brain 5-HT and a possible mode of action.
Topics: Animals; Behavior, Animal; Brain; Brain Chemistry; Depression, Chemical; Injections, Intraperitoneal; Liver; Male; Motor Activity; NAD; Niacinamide; Rats; Serotonin; Stimulation, Chemical; Tryptophan Oxygenase | 1972 |
Pyridine nucleotide biosynthesis in Claviceps.
Topics: Ascomycota; Carbon Isotopes; Chromatography, Paper; Chromatography, Thin Layer; Culture Media; Hydrolysis; NAD; Niacinamide; Nicotinic Acids; Nucleotides; Pyridines; Solvents; Time Factors; Tryptophan | 1973 |
Effect of pyrazinamide on nicotinamide adenine dinucleotide glycohydrolase of tuberculous host.
Topics: Animals; Drug Resistance, Microbial; Isoniazid; Liver; Male; Mice; Mycobacterium Infections; Mycobacterium tuberculosis; N-Glycosyl Hydrolases; NAD; Niacinamide; Pyrazinamide | 1973 |
Metabolism of NAD after whole-body irradiation. IV. Incorporation of nicotinamide by isolated perfused liver and by intact rats.
Topics: Animals; Brain; Carbon Isotopes; In Vitro Techniques; Intestinal Mucosa; Kidney; Liver; Male; Muscles; NAD; Niacinamide; Nicotinic Acids; Perfusion; Radiation Injuries, Experimental; Rats; Spleen; Testis | 1972 |
The inhibition of pig kidney alkaline phosphatase by oxidized or reduced nicotinamide-adenine dinucleotide and related compounds.
Topics: Adenosine; Alkaline Phosphatase; Animals; Binding Sites; Drug Stability; Guanidines; Kidney; Kinetics; Mathematics; Models, Chemical; NAD; Niacinamide; Oxidation-Reduction; Protein Denaturation; Spectrophotometry; Swine; Time Factors | 1973 |
[Significance of nicotinic acid amide for the biosynthesis of NAD in the isolated perfused rat liver].
Topics: Animals; In Vitro Techniques; Liver; NAD; Niacinamide; Nicotinic Acids; Perfusion; Rats; Tryptophan | 1972 |
Bull semen nicotinamide adenine dinucleotide nucleosidase. IV. Nonpolar interactions of inhibitors with the substrate binding site.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Alkanes; Animals; Binding Sites; Binding, Competitive; Carboxylic Acids; Cattle; Kinetics; Male; N-Glycosyl Hydrolases; NAD; Niacinamide; Phosphoric Acids; Protein Binding; Semen; Structure-Activity Relationship | 1972 |
Cross-feeding of Escherichia coli mutants defective in the biosynthesis of nicotinamide adenine dinucleotide.
Topics: Amino Acids; Culture Media; Enzyme Precursors; Escherichia coli; Mutation; NAD; Niacinamide; Nicotinic Acids; Pyridines | 1973 |
Protein binding of nicotinamide adenine dinucleotide and regulation of nicotinamide adenine dinucleotide glycohydrolase activity in homogenates of rabbit skeletal muscle.
Topics: Animals; Binding Sites; Chromatography, Gel; Female; Muscles; N-Glycosyl Hydrolases; NAD; Niacinamide; Oxidation-Reduction; Protein Binding; Rabbits; Spectrophotometry, Ultraviolet; Time Factors; Ultrafiltration | 1973 |
Structure of analogs of nicotinamide-adenine dinucleotide. I. Crystal structure of N-(3-(aden-9-yl)propyl)-3-carbamoylpyridinium bromide trihydrate, (Ade-C3-Nic+)Br-3H2O.
Topics: Adenine; Binding Sites; Crystallography; Cyclization; Hydrogen; Models, Chemical; Molecular Conformation; NAD; Niacinamide | 1973 |
Structures of analogs of nicotinamide-adenine dinucleotide. II. Crystal structure of N-(3-(Aden-9-yl) propyl)-3-carbamoylpyridinium bromide hydrobromide dihydrate, (AdeH plus-C3-Nic+)2Br-2H2O.
Topics: Adenine; Binding Sites; Crystallography; Cyclization; Models, Chemical; NAD; Niacinamide | 1973 |
Structures of analogs of nicotinamide-adenine dinucleotide. 3. Crystal structure of 1,1'-trimethylenebisnicotinamide dichloride monohydrate, (Nic plus-C3-Nic+)2CL-H2O.
Topics: Binding Sites; Crystallography; Hydrogen; Models, Chemical; Molecular Conformation; NAD; Niacinamide; X-Ray Diffraction | 1973 |
Nuclear magnetic resonance studies on pyridine dinucleotides. I. The pH dependence of the carbon 13 nuclear magnetic resonance of nicotinamide adenine dinucleotide.
Topics: Benzamides; Carbon Isotopes; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Models, Chemical; NAD; Niacinamide; Oxidation-Reduction; Protons; Pyridines | 1973 |
Biosynthesis of NAD in Haemophilus haemoglobinophilus.
Topics: Carbon Radioisotopes; Chromatography, Paper; Electrophoresis, Paper; Haemophilus; NAD; Niacinamide; Nicotinamide Mononucleotide; Nicotinic Acids; Pentosyltransferases; Pyridines; Ribose | 1973 |
Response of mitochondrial enzymes to decreased muscular activity.
Topics: Animals; Calcium; Electron Transport Complex IV; Hindlimb; Immobilization; Malate Dehydrogenase; Male; Mitochondria, Muscle; Monoamine Oxidase; Muscle Proteins; Muscular Atrophy; NAD; Niacinamide; Nucleotides; Rats; Time Factors | 1973 |
Binding of NAD+ to rabbit-muscle glyceraldehydephosphate dehydrogenase. The use of N-methylnicotinamidium chloride as a spectral and conformational probe.
Topics: Animals; Binding Sites; Electron Transport; Energy Transfer; Glyceraldehyde-3-Phosphate Dehydrogenases; Iodoacetates; Muscles; NAD; Niacinamide; Protein Binding; Protein Conformation; Rabbits; Spectrophotometry, Ultraviolet; Sulfhydryl Reagents | 1973 |
Streptozotocin diabetes--further studies on the mechanism of depression of nicotinamide adenine dinucleotide concentrations in mouse pancreatic islets and liver.
Topics: Animals; Carbon Radioisotopes; Diabetes Mellitus; In Vitro Techniques; Islets of Langerhans; Liver; Male; Mice; NAD; Niacinamide; Radiometry; Ribonucleotides; Streptozocin; Time Factors; Tritium | 1973 |
Biliary excretion of nicotinamide riboside. A possible role in the regulation of hepatic pyridine nucleotide dynamics.
Topics: Animals; Bile; Carbon Radioisotopes; Chromatography, Gel; Chromatography, Paper; Electrophoresis, Paper; Female; Fluorometry; Freeze Drying; Liver; Methylation; NAD; Niacinamide; Nicotinamide Mononucleotide; Nicotinic Acids; Rats; Ribonucleosides; Time Factors | 1973 |
Molecular properties of lactic dehydrogenase under the conditions of the enzymatic test. Sedimentation analysis and gel filtration in the microgram and nanogram range.
Topics: Adenosine Triphosphate; Animals; Chromatography, Gel; Circular Dichroism; Enzyme Activation; Isoenzymes; L-Lactate Dehydrogenase; Macromolecular Substances; Microchemistry; Molecular Weight; Myocardium; NAD; Niacinamide; Protein Conformation; Swine; Ultracentrifugation | 1973 |
Interruption of the sequential release of small and large molecules from tumor cells by low temperature during cytolysis mediated by immune T-cells or complement.
Topics: Animals; Antigen-Antibody Reactions; Antilymphocyte Serum; Autoradiography; Carbon Radioisotopes; Cell Line; Cells, Cultured; Chromium Radioisotopes; Cold Temperature; Complement System Proteins; Cytotoxicity Tests, Immunologic; Edetic Acid; Kinetics; Male; Mast-Cell Sarcoma; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Weight; NAD; Niacinamide; Osmotic Fragility; Sarcoma, Experimental; T-Lymphocytes | 1974 |
Poly(adenosine diphosphoribose) polymerase in mammalian nuclei. Characterization of the activity in mouse fibroblasts (LS cells).
Topics: Adenosine Diphosphate; Animals; Calcium; Cell Line; Cell Nucleus; Chemical Phenomena; Chemistry, Physical; Deoxyribonucleases; DNA; Drug Stability; Enzyme Activation; Hydrogen-Ion Concentration; Kinetics; L Cells; Magnesium; Mice; NAD; Niacinamide; Nucleotidyltransferases; Poly U; Polynucleotides; Ribonucleases; Ribose; Temperature; Thymidine; Tritium | 1973 |
Activity of liver alcohol dehydrogenase with various substituents on the amino groups.
Topics: Alcohol Oxidoreductases; Alkylation; Animals; Benzene Derivatives; Binding Sites; Carbamates; Chemical Phenomena; Chemistry; Enzyme Activation; Horses; Hydrogen-Ion Concentration; Imides; Kinetics; Liver; NAD; Niacinamide; Oxidation-Reduction; Picolinic Acids; Protein Binding; Structure-Activity Relationship; Succinates | 1974 |
Interaction of fragment A from diphtheria toxin with nicotinamide adenine dinucleotide.
Topics: Animals; Binding Sites; Carbon Radioisotopes; Chromatography, Paper; Dialysis; Diphtheria Toxin; Electrophoresis, Disc; Models, Chemical; N-Glycosyl Hydrolases; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Oxidation-Reduction; Peptide Elongation Factors; Peptide Fragments; Protein Biosynthesis; Rabbits; Reticulocytes; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Trypsin; Ultracentrifugation | 1974 |
Stereochemistry of hydrogen transfer between pyridine nucleotide and some intermediates of cholesterol catabolism catalyzed by liver alcohol and aldehyde dehydrogenase.
Topics: Acetaldehyde; Alcohol Oxidoreductases; Aldehyde Oxidoreductases; Animals; Cholestanes; Cholesterol; Chromatography; Chromatography, Ion Exchange; Crystallization; Horses; Hydrogen; Hydroxyapatites; Hydroxysteroid Dehydrogenases; Liver; NAD; Niacinamide; Oxidation-Reduction; Rats; Spectrophotometry, Ultraviolet; Tritium | 1974 |
The equilibria and reaction rates of nicotinamide-adenine dinucleotide and its related compounds with cyanide ion in the presence of polyelectrolytes.
Topics: Allyl Compounds; Chemical Phenomena; Chemistry; Cyanides; DNA; Kinetics; NAD; Niacinamide; Nicotinamide Mononucleotide; Polymers; Polynucleotides; Polyvinyls; Pyridinium Compounds; Quaternary Ammonium Compounds; Ribonucleotides; Surface-Active Agents; Thermodynamics | 1974 |
A Raman and infrared spectroscopic study of the 3-carbonyl group of pyridine nucleotide coenzymes and related model compounds.
Topics: Acetates; Aldehydes; Chemical Phenomena; Chemistry; Coenzymes; Deuterium; Dioxins; Drug Stability; Models, Chemical; NAD; Niacinamide; Nicotinamide Mononucleotide; Nicotinic Acids; Oxidation-Reduction; Pyridines; Ribonucleotides; Spectrophotometry, Infrared; Spectrum Analysis | 1974 |
Increase in hepatic NAD level--its effect on the redox state and on ethanol and acetaldehyde metabolism.
Topics: Acetaldehyde; Animals; Cytoplasm; Ethanol; Kinetics; Lactates; Liver; Male; NAD; Niacinamide; Oxidation-Reduction; Pyruvates; Rats; Subcellular Fractions; Time Factors | 1974 |
Simple methods of preparing nicotinamide mononucleotide.
Topics: Animals; Chromatography, Affinity; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis; Evaluation Studies as Topic; Horses; L-Lactate Dehydrogenase; Methods; NAD; Niacinamide; Nicotinamide Mononucleotide; Plants; Pyrophosphatases; Ribonucleotides; Spectrophotometry, Ultraviolet | 1974 |
Letter: NAD and chronic schizophrenia.
Topics: Chronic Disease; Drug Evaluation; Drug Therapy, Combination; Humans; NAD; Niacinamide; Nicotinic Acids; Schizophrenia | 1974 |
Radiation effects on NAD-and DNA-metabolism in mouse spleen.
Topics: Animals; Carbon Radioisotopes; Cell Nucleus; DNA; Dose-Response Relationship, Radiation; Electrophoresis; Kinetics; Mice; Mice, Inbred Strains; N-Glycosyl Hydrolases; NAD; Niacinamide; Nucleotidyltransferases; Radiation Effects; Spleen; Thymidine; Time Factors; Tritium | 1974 |
Proton relaxation studies of diphosphopyridine coenzymes.
Topics: Animals; Binding Sites; Chickens; Deuterium; Fourier Analysis; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; Magnetic Resonance Spectroscopy; Mathematics; Models, Biological; Molecular Conformation; Muscles; NAD; Niacinamide; Oxidation-Reduction; Protein Binding; Structure-Activity Relationship; Time Factors | 1974 |
Different half-lives of nicotinamide and adenine moieties of NAD in HeLa S3 cultures.
Topics: Adenine; Adenosine; Carbon Radioisotopes; Chromatography, Ion Exchange; Half-Life; HeLa Cells; Humans; Isotope Labeling; Kinetics; NAD; Niacinamide; Nicotinic Acids; Time Factors; Triaziquone | 1973 |
[Phosphorus compounds and their metabolites in ischemic heart diseases].
Topics: Adenine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Aged; Chromatography, Thin Layer; Coronary Disease; Creatine Kinase; Female; Hematocrit; Hemoglobins; Humans; Male; Middle Aged; NAD; Niacinamide; Organophosphorus Compounds; Phosphorus | 1974 |
Histochemical changes in the rat spinal cord after exposure to 6-aminonicotinamide.
Topics: Acetylcholinesterase; Adenosine Triphosphatases; Animals; Anterior Horn Cells; Esterases; Ganglia, Spinal; Glucosephosphate Dehydrogenase; Histocytochemistry; L-Lactate Dehydrogenase; Lipid Metabolism; Male; Muscles; NAD; Neuroglia; Niacinamide; Rats; Rats, Inbred Strains; Spinal Cord; Succinate Dehydrogenase | 1974 |
Cytotoxic effects of streptozotocin and N-nitrosomethylurea on the pancreatic B cells with special regard to the role of nicotinamide-adenine dinucleotide.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Female; Glucose; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred Strains; NAD; Niacinamide; Nitrosourea Compounds; Obesity; Oxygen Consumption; Streptozocin | 1974 |
[Participation of nicotinamide-hypoxanthine-dinucleotide (deamino-NAD) in nitrogen and energy metabolism].
Topics: Adenosine Monophosphate; Alcohol Oxidoreductases; Ammonia; Animals; Antimycin A; Aspartic Acid; Brain; Brain Chemistry; Cell Nucleus; Deamination; Energy Metabolism; Glutamates; Glycolysis; Ketoglutaric Acids; Microsomes; Mitochondria; Mitochondria, Liver; NAD; Niacinamide; Nitrogen; Nitrogen Isotopes; Nucleotides; Oxidative Phosphorylation; Rabbits; Rats; Rotenone; Subcellular Fractions; Succinates; Time Factors; Transaminases; Yeasts | 1973 |
Poly(ADP-ribose) synthesis and cell division.
Topics: Adenosine; Cell Division; Cell Nucleus; Drug Resistance; HeLa Cells; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Polynucleotides; Ribose | 1974 |
Proceedings: Biosynthesis of nicotinamide adenine dinucleotide in mitochondria.
Topics: Adenosine Triphosphate; Animals; Mitochondria, Liver; NAD; Niacinamide; Rats | 1974 |
New aspects of the mechanism and regulation of pyridine nucleotide metabolism.
Topics: Animals; In Vitro Techniques; Kinetics; Liver; Mitochondria, Liver; Models, Biological; NAD; Niacinamide; Nicotinic Acids; Perfusion; Rats | 1974 |
[Proceedings: NAD biosynthesis from tryptophan in mouse liver].
Topics: Animals; DNA; Hydrolases; Kynurenine; Liver; Liver Regeneration; Mice; NAD; Niacinamide; Nicotinic Acids; Thymidine; Tryptophan | 1972 |
The conformation of pyridine dinucleotides in solution.
Topics: Adenine Nucleotides; Chemical Phenomena; Chemistry, Physical; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; NAD; NADP; Niacinamide; Nucleotides; Solutions; Thermodynamics | 1966 |
On the interaction of 1-alkyl pyridinium couples.
Topics: Chemical Phenomena; Chemistry; NAD; NADP; Niacinamide; Solutions; Spectrum Analysis | 1964 |
The fine structural localization and selective inhibition of nucleosidephosphatases in the rat adrenal cortex.
Topics: Acid Phosphatase; Adrenal Glands; Animals; Cell Nucleus; Endoplasmic Reticulum; Glycerophosphates; Golgi Apparatus; Guanine Nucleotides; Histocytochemistry; Mitochondria; NAD; NADP; Niacinamide; Nucleotides; Phosphoric Monoester Hydrolases; Rats | 1965 |
[The effect of 6-aminonicotinamide on the distribution of sodium and potassium ions between the extracellular and intracellular space in the liver and skeletal muscles].
Topics: Animals; Liver; Muscles; NAD; NADP; Niacinamide; Potassium; Rats; Sodium | 1966 |
Solubilization and comparative properties of some mammalian diphosphopyridine nucleosidases.
Topics: Animals; Brain; Cattle; Chromatography, Gel; Dogs; Electrophoresis; Enzymes; Horses; Humans; Liver; Lung; Mice; Molecular Weight; N-Glycosyl Hydrolases; NAD; NADP; Niacinamide; Rabbits; Rats; Sheep; Solubility; Species Specificity; Spleen; Swine | 1967 |
Feedback control of rat liver tryptophan pyrrolase. I. End product inhibition of trytophan pyrrolase activity.
Topics: Animals; Buffers; Chromatography; Electrophoresis; Enzymes; Hot Temperature; Kinetics; Liver; Molecular Weight; NAD; NADP; Niacinamide; Nicotinic Acids; Nucleotides; Oxidoreductases; Rats; Tryptophan; Ultracentrifugation | 1967 |
Bone nicotinamide adenine dinucleotide levels in response to nicotinamide and parathyroid extract injections.
Topics: Animals; Bone and Bones; In Vitro Techniques; Liver; NAD; NADP; Niacinamide; Parathyroid Hormone; Rabbits | 1966 |
The effect of nicotinamide adenine dinucleotide on lipolysis in adipose tissue in vitro.
Topics: Adenine; Adenine Nucleotides; Adenosine Triphosphate; Adipose Tissue; Animals; Antimetabolites; Epididymis; Fatty Acids; Fatty Acids, Nonesterified; In Vitro Techniques; Male; NAD; NADP; Niacinamide; Nicotinic Acids; Nucleosides; Nucleotides; Rats | 1966 |
Cyclic voltammetry of the pyridine nucleotides and a series of nicotinamide model compounds.
Topics: Electrochemistry; NAD; NADP; Niacinamide; Oxidation-Reduction; Pyridines | 1967 |
Enzymatic decyanation of cyanocobalamin in rat tissues.
Topics: Animals; Brain; Chromatography, Thin Layer; Coenzymes; Cyanides; Enzymes; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; In Vitro Techniques; Ions; Kidney; Liver; Lung; Male; Myocardium; NAD; NADP; Niacinamide; Rats; Riboflavin; Spectrophotometry; Spleen; Vitamin B 12 | 1967 |
[Pyridine nucleotide metabolism in rat liver during carcinogenesis].
Topics: Animals; Dactinomycin; Hepatectomy; Liver; Liver Neoplasms; Liver Regeneration; Morpholines; NAD; NADP; Niacinamide; Nitroso Compounds; Precancerous Conditions; Rats; Sarcoma, Experimental | 1966 |
The effect of nicotinamide and homologs on the activity of inducible enzymes and NAD content of the rat liver.
Topics: Animals; Brain; Dactinomycin; Enzyme Induction; Hydrocortisone; Hypophysectomy; Isoniazid; Kidney; Liver; Male; Muscles; Myocardium; NAD; Niacinamide; Nicotinic Acids; Nikethamide; Pyridines; Rats; Tryptophan Oxygenase; Tyrosine Transaminase | 1967 |
The protective effect of nicotinamide on carbon tetrachloride-induced hepatotoxicity.
Topics: Animals; Antidotes; Body Temperature; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Female; Liver; Mitochondria, Liver; NAD; NADP; Niacinamide; Rats; Temperature | 1967 |
Turnover of NAD in bacteria.
Topics: Carbon Isotopes; Culture Media; Escherichia coli; Lactobacillus; Leuconostoc; NAD; NADP; Niacinamide; Nicotinic Acids; Staphylococcus | 1967 |
Interrelation of stromal NAD(P)ase and human erythrocytic 6-phosphogluconic dehydrogenase.
Topics: Cell Membrane; Electrophoresis; Erythrocytes; Humans; N-Glycosyl Hydrolases; NAD; NADP; Niacinamide; Phosphogluconate Dehydrogenase | 1968 |
Studies of nicotinic acid metabolism in Astasia longa. I. Incorporation of nicotinic acid into pyridine derivatives in exponentially growing and in synchronized cultures.
Topics: Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Paper; Eukaryota; Guanine Nucleotides; Kinetics; NAD; NADP; Niacinamide; Nicotinic Acids; Nucleotides; Periodicity; Pyridines; Spectrum Analysis; Ultraviolet Rays | 1968 |
Studies of nicotinic acid metabolism in Astasia longa. II. Pathway and regulation of nicotinamide adenine dinucleotide biosynthesis in cell-free preparations.
Topics: Carbon Isotopes; Cell-Free System; Chromatography, Paper; Enzyme Repression; Eukaryota; Ligases; NAD; NADP; Niacinamide; Nicotinic Acids; Nucleotides; Phosphotransferases; Pyridines; Transferases | 1968 |
Non-glycolytic sugar metabolism in human erythrocytes. I. Xylitol metabolism.
Topics: Alcohols; Chromatography, Gas; Chromatography, Paper; Edetic Acid; Erythrocytes; Humans; Methemoglobin; NAD; NADP; Niacinamide; Xylitol | 1967 |
Effects of ACTH and whole-body x-irradiation on the concentrations of enzymes, nicotinamide nucleotides and cytochromes in the rat adrenal.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Cytochromes; DNA; Male; Mitochondria; NAD; NADP; Niacinamide; Nucleotides; Nucleotidyltransferases; Peroxidases; Radiation Effects; Rats; RNA; Succinate Dehydrogenase | 1967 |
Localization and regulation of two NAD nucleosidases in Ehrlich ascites cells.
Topics: Acid Phosphatase; Animals; Carcinoma, Ehrlich Tumor; Cell Nucleus; Centrifugation; Lysosomes; Microsomes; N-Glycosyl Hydrolases; NAD; NADP; Niacinamide; Nucleotidyltransferases; Oxidoreductases | 1968 |
[Studies on the concentration of 6-aminonicotinamide analogs of NAD(P) in tumors].
Topics: Animals; Carcinosarcoma; Cyclophosphamide; N-Glycosyl Hydrolases; NAD; NADP; Niacinamide; Rats; Sarcoma, Experimental; Sarcoma, Yoshida | 1967 |
Effect of nicotinamide in vivo on thyroid pyridine nucleotides and radioiodine metabolism.
Topics: Animals; Diiodotyrosine; Iodides; Iodine Isotopes; Iodoproteins; Male; NAD; NADP; Niacinamide; Rats; Stimulation, Chemical; Thyroid Gland; Thyroxine; Triiodothyronine; Tyrosine | 1968 |
[Nicotinic acid and experimental tumor growth].
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cachexia; Depression, Chemical; NAD; NADP; Neoplasms, Experimental; Niacinamide; Nicotinic Acids; Nucleotides; Rats; Vitamin B Deficiency | 1966 |
Pyridine nucleotides in renal ammonia metabolism.
Topics: Acidosis; Ammonia; Animals; Chronic Disease; Dogs; Glutamates; Hydrogen-Ion Concentration; Kidney; Kidney Glomerulus; Kidney Tubules; Malonates; Mitochondria; NAD; NADP; Niacinamide; Oxidation-Reduction; Rats | 1968 |
Regulation of NAD biosynthesis via the pyridine nucleotide cycle.
Topics: Adenosine Triphosphate; Animals; Bacillus; Carbon Isotopes; Escherichia coli; Hypophysectomy; In Vitro Techniques; Liver; NAD; NADP; Niacinamide; Nicotinic Acids; Nucleotides; Pyridines; Pyrophosphatases; Rats; Transferases; Tryptophan; Tryptophan Oxygenase | 1968 |
NAD synthesis in animal tissues.
Topics: Adenosine Triphosphate; Animals; Autoradiography; Brain; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Electrophoresis; Female; Kidney; Liver; Mammals; Mice; Muscles; NAD; NADP; Neoplasms, Experimental; Niacinamide; Nicotinic Acids; Nitrogen; Phosphotransferases; Pyridines; Rats; Uterus | 1968 |
Prevention and remission by adrenocortical steriods of nicotinamide deficiency disease. II. A study of the mechanism.
Topics: Adrenal Cortex Hormones; Animals; Corticosterone; Deficiency Diseases; NAD; NADP; Niacinamide; Nucleotides; Pyridines; Rats; Tryptophan | 1968 |
Studies on reduction of azo-linkages in human placental homogenates.
Topics: Azo Compounds; Carbon Monoxide; Edetic Acid; Female; Flavins; Glucosephosphate Dehydrogenase; Glutathione; Hexosephosphates; Humans; Hydrogen-Ion Concentration; Magnesium; NAD; NADP; Niacinamide; Oxygen; Phosphogluconate Dehydrogenase; Placenta; Pregnancy; Sulfhydryl Compounds | 1968 |
[Effect of corticosteroids on nicotinic acid metabolism].
Topics: Acetates; Animals; Cortisone; Depression, Chemical; Desoxycorticosterone; Dogs; Injections, Subcutaneous; Methods; NAD; NADP; Niacinamide; Nicotinic Acids; Stimulation, Chemical | 1967 |
Rabbit erythrocyte pyridinnucleotides and nucleosidase activity after x-ray irradiation.
Topics: Animals; Erythrocytes; N-Glycosyl Hydrolases; NAD; NADP; Niacinamide; Rabbits; Radiation Effects; Time Factors | 1968 |
Pattern of nicotinamide nucleotides in the erythrocytes of pellagrins.
Topics: Chromatography, Paper; Erythrocytes; Humans; India; Models, Biological; NAD; NADP; Niacinamide; Nucleotides; Pellagra | 1968 |
Functional disorders of the brain induced by synthesis of nucleotides containing 3-acetylpyridine.
Topics: Adenine Nucleotides; Animals; Brain; Brain Diseases; Cerebral Cortex; Folic Acid Antagonists; Glucosephosphate Dehydrogenase; Hippocampus; Kinetics; Malate Dehydrogenase; Microscopy, Electron; Movement Disorders; N-Glycosyl Hydrolases; NAD; NADP; Neuroglia; Niacinamide; Phosphogluconate Dehydrogenase; Pyridines; Rats; RNA Nucleotidyltransferases | 1968 |
[Change in the content of the nicotinamide coenzymes in the liver of albino rats under the effect of thiophosamide].
Topics: Animals; Liver; NAD; NADP; Niacinamide; Oxidation-Reduction; Rats; Stimulation, Chemical; Thiotepa; Time Factors | 1968 |
A colorimetric method for the quantitative determination of reduced pyridine nucleotides (NADPH and NADH).
Topics: Adenine Nucleotides; Adenosine Triphosphate; Aldehydes; Aniline Compounds; Animals; Female; Hydrocortisone; Liver; Male; Methods; NAD; NADP; Niacinamide; Rats; Spectrophotometry; Spectrum Analysis | 1968 |
Nicotinamide-adenine dinucleotide pyrophosphatase of Cambaroides japonica.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Alcohol Oxidoreductases; Animals; Chemical Precipitation; Chromatography, Ion Exchange; Chromatography, Paper; Crustacea; Cyanides; Guanine Nucleotides; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Liver; Microsomes; Mitochondria; N-Glycosyl Hydrolases; NAD; NADP; Niacinamide; Pancreas; Phosphoric Monoester Hydrolases; Uracil Nucleotides | 1969 |
Structure--activity and metabolism studies on organophosphate teratogens and their alleviating agents in developing hen eggs with special emphasis on Bidrin.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Butyrates; Chick Embryo; Cholinesterase Inhibitors; Methylation; NAD; NADP; Niacinamide; Nicotinic Acids; Nucleotides; Phosphoric Acids; Phosphorus Isotopes; Time Factors | 1969 |
Effect of oxamate, pyruvate, nicotinamide and streptozotocin on the pentose phosphate pathway intermediates in ascites tumour cells.
Topics: Animals; Antibiotics, Antineoplastic; Carbon Dioxide; Carbon Isotopes; Depression, Chemical; Glucose; Mice; NAD; NADP; Neoplasms, Experimental; Niacinamide; Oxalates; Oxidation-Reduction; Pentosephosphates; Pyruvates; Stimulation, Chemical | 1969 |
Conformation and conformational changes of reduced diphosphospyridine nucleotide in solution.
Topics: Adenine; Binding Sites; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; NAD; NADP; Niacinamide; Oxidation-Reduction; Oxidoreductases; Solutions; Spectrum Analysis; Ultraviolet Rays | 1969 |
[Pharmacologic and biochemical properties of thionicotinamide (thio-NA) and its NAD (P)-analogues].
Topics: Animals; Biotransformation; Brain; Chemical Phenomena; Chemistry; Glucosephosphate Dehydrogenase; Glutathione Reductase; Isocitrate Dehydrogenase; Kinetics; Liver; Malate Dehydrogenase; NAD; NADP; Niacinamide; Rats; Sulfhydryl Compounds | 1968 |
Pyridine coenzymes. 8. Autoxidation of the reduced form catalyzed by 4-amino-2,6-diiodophenol.
Topics: Chemical Phenomena; Chemistry; Electron Transport; Hydrogen-Ion Concentration; Iodine; Kinetics; Light; Manometry; Models, Chemical; NAD; NADP; Niacinamide; Oxidation-Reduction; Oxygen; Phenols; Pyridines; Pyridinium Compounds; Spectrophotometry; Ultraviolet Rays | 1969 |
Oxidative enzyme components of avian liver microsomes. Changes during embryonic development and the effects of phenobarbital administration.
Topics: Animals; Chick Embryo; Chickens; Cyanides; Cytochromes; Electron Transport; Liver; Microsomes; NAD; NADP; Niacinamide; Oxidoreductases; Phenobarbital; Spectrophotometry; Spectrum Analysis | 1969 |
Some properties of the microsomal system metabolizing DDT in Triatoma infestans.
Topics: Animals; Chloromercuribenzoates; DDT; Depression, Chemical; Enzyme Induction; Hydrogen-Ion Concentration; Insecta; Kinetics; Magnesium; Microsomes; NAD; NADP; Niacinamide; Phenobarbital; Stimulation, Chemical; Sulfhydryl Compounds; Temperature; Time Factors; Triatominae | 1969 |
Metabolic control and structure of glycolytic enzymes. VI. Competitive inhibition of yeast glyceraldehyde 3-phosphate dehydrogenase by cyclic adenosine monophosphate, adenosine triphosphate, and other adenine-containing compounds.
Topics: Adenine; Adenine Nucleotides; Adenosine Triphosphate; Chemical Phenomena; Chemistry; Cyclic AMP; Glyceraldehyde-3-Phosphate Dehydrogenases; Kinetics; NAD; NADP; Niacinamide; Nucleosides; Nucleotides; Protein Binding; Pyridines; Saccharomyces; Spectrophotometry | 1969 |
NAD+ induced nucleoside specificity of oxidative phosphorylation.
Topics: Adenine Nucleotides; Aniline Compounds; Animals; Antimycin A; Ascorbic Acid; Cattle; Depression, Chemical; Hexokinase; Iron; Mitochondria, Muscle; Myocardium; NAD; NADP; Niacinamide; Nucleotides; Oxidative Phosphorylation; Rotenone; Succinates | 1969 |
Control of the steady-state concentrations of the nicotinamide nucleotides in rat liver.
Topics: Adenosine Triphosphate; Animals; Ethionine; Kinetics; Liver; Microsomes; N-Glycosyl Hydrolases; NAD; NADP; Niacinamide; Phosphotransferases; Rats | 1969 |
Effect in man of the addition of tryptophan oniacin to the diet on the excretion of their metabolites.
Topics: Creatinine; Diet; Female; Humans; Kynurenic Acid; NAD; NADP; Niacinamide; Nicotinic Acids; Nitrogen; Pyridones; Tryptophan; Urea; Xanthurenates | 1969 |
[Nicotinamide adenine dinucleotidase from rat liver and some of its properties].
Topics: Animals; Centrifugation; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Hypoxanthines; Liver; Methods; N-Glycosyl Hydrolases; NAD; NADP; Niacinamide; Pyridines; Rats; Temperature | 1969 |
[Glutamate dehydrogenase. Attachment of NAD and NADP coenzymes and other nucleotides derived from adenosine-5'-phosphate].
Topics: Adenine Nucleotides; Animals; Binding Sites; Glutamate Dehydrogenase; Guanine Nucleotides; Kinetics; Light; Liver; Molecular Weight; NAD; NADP; Niacinamide; Osmolar Concentration; Sodium Chloride; Spectrum Analysis; Swine | 1969 |
High frequency nuclear magnetic resonance study of the M and P helices of reduced pyridine dinucleotides.
Topics: Chemical Phenomena; Chemistry; Computers; Ferricyanides; Magnetic Resonance Spectroscopy; Methods; Models, Chemical; Models, Structural; NAD; NADP; Niacinamide; Nucleotides; Oxidation-Reduction | 1970 |
Investigation of the configuration and conformation of N-methyl-N-ethylnicotinamide-adenine dinucleotide by nuclear magnetic resonance spectroscopy.
Topics: Chemical Phenomena; Chemistry; Magnetic Resonance Spectroscopy; Methods; Models, Structural; NAD; NADP; Niacinamide; Nucleotides; Stereoisomerism; Temperature | 1970 |
High frequency nuclear magnetic resonance investigation of the backbone of oxidized and reduced pyridine nucleotides.
Topics: Chemical Phenomena; Chemistry; Hypoxanthines; Magnetic Resonance Spectroscopy; Methods; NAD; NADP; Niacinamide; Nucleotides; Oxidation-Reduction; Ribose | 1970 |
Intra-amniotic injection of pyridine nucleotides or adenosine triphosphate as countertherapy for 6-aminonicotinamide (6-AN) teratogenesis.
Topics: Abnormalities, Drug-Induced; Adenosine Triphosphate; Amnion; Animals; Female; Fetus; Injections; Male; NAD; NADP; Niacinamide; Placenta; Rats | 1970 |
The mechanism of glutamate dehydrogenase reaction. 3. The binding of ligands at multiple subsites and resulting kinetic effects.
Topics: Adenine Nucleotides; Amino Acids; Binding Sites; Glutamate Dehydrogenase; Glutamates; Guanine Nucleotides; Kinetics; Models, Chemical; NAD; NADP; Niacinamide; Protein Binding; Pyridines; Quaternary Ammonium Compounds | 1970 |
Stereospecificity of hydrogen transfer reactions of the Pseudomonas aeruginosa pyridine nucleotide transhydrogenase.
Topics: Adenine Nucleotides; Chemical Phenomena; Chemistry; Circular Dichroism; Flavin-Adenine Dinucleotide; Hydrogen; NAD; NADP; Niacinamide; Oxidoreductases; Pseudomonas aeruginosa; Spectrophotometry; Temperature; Tritium; Urea | 1970 |
[Experimental brain edema caused by 6-aminonicotinamide--an antimetabolite of nicotinic acid].
Topics: Animals; Antimetabolites; Brain; Brain Edema; Myocardium; NAD; NADP; Niacinamide; Nicotinic Acids; Potassium; Rats; Sodium; Water-Electrolyte Balance | 1968 |
Conformation of pyridine dinucleotides in solution.
Topics: Chemical Phenomena; Chemistry; Magnetic Resonance Spectroscopy; Models, Chemical; NAD; NADP; Niacinamide; Nucleotides; Pyridines; Solutions; Stereoisomerism | 1971 |
[Change in the content of some vitamins in albino rat organs and urine during the chronic administration of 3,4-benzpyrene and sulfur dioxide].
Topics: Air Pollution; Animals; Ascorbic Acid; Benzopyrenes; Brain; Female; Liver; Male; NAD; NADP; Niacinamide; Pyruvates; Rats; Riboflavin; Sulfur Dioxide; Thiamine; Time Factors; Vitamins | 1970 |
[The activity of N- and O-demethylase in the human liver].
Topics: Aniline Compounds; Animals; Biopsy; Glucose-6-Phosphatase; Humans; In Vitro Techniques; Liver; Microsomes, Liver; NAD; NADP; Niacinamide; Nitrophenols; Oxidoreductases; Phosphoric Monoester Hydrolases; Proteins; Rats; Species Specificity; Spectrophotometry | 1970 |
Metabolism of cyclophosphamide by rat hepatic microsomes.
Topics: Adrenal Glands; Alkylation; Animals; Carbon Dioxide; Carcinosarcoma; Cyclophosphamide; Female; Freezing; Kidney; Kinetics; Liver; Male; Microsomes, Liver; Morphinans; NAD; NADP; Niacinamide; Oxidation-Reduction; Rats; Temperature; Thymus Gland | 1971 |
pH-dependent inactivation of nicotinamide--adenine dinucleotide glycohydrolase by its substrate, oxidized nicotinamide--adenine dinucleotide.
Topics: Adenine Nucleotides; Animals; Binding Sites; Carcinoma, Ehrlich Tumor; Cell Line; Cell Nucleus; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Microsomes; N-Glycosyl Hydrolases; NAD; NADP; Niacinamide; Pentosephosphates; Ribose; Temperature | 1971 |
Microsomal electron transport reactions. II. The use of reduced triphosphopyridine nucleotide and-or reduced diphosphopyridine nucleotide for the oxidative N-demethylation of aminopyrine and other drug substrates.
Topics: Aminopyrine; Animals; Codeine; Dealkylation; Electron Transport; Fasting; Formaldehyde; Kinetics; Male; Methylation; Microsomes; Microsomes, Liver; Morphinans; NAD; NADP; Niacinamide; Oxidation-Reduction; Oxidoreductases; Rabbits | 1971 |
Microsomal electron transport reactions. 3. Cooperative interactions between reduced diphosphopyridine nucleotide and reduced triphosphopyridine nucleotide linked reactions.
Topics: Aminopyrine; Animals; Cytochromes; Electron Transport; Fasting; Fluorometry; Formaldehyde; Isocitrate Dehydrogenase; Male; Microsomes, Liver; Models, Biological; NAD; NADP; Niacinamide; Oxidation-Reduction; Oxidoreductases; Rabbits; Spectrophotometry | 1971 |
Phosphate catalysis in the autoxidation of 1-n-propyl-6-hydroxy-1,4,5,6-tetrahydronicotinamide. A model for adenosine triphosphate formation.
Topics: Adenosine Triphosphate; Aniline Compounds; Arsenic; Catalysis; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chromatography, Paper; Deuterium; Kinetics; NAD; NADP; Niacinamide; Organophosphorus Compounds; Oxidation-Reduction; Oxygen Consumption; Phosphates; Phosphoric Acids; Potentiometry; Pyridinium Compounds; Spectrophotometry; Ultraviolet Rays | 1971 |
[Separation and identification of products of nicotinic acid metabolism in rat liver].
Topics: Animals; Chromatography, Paper; Electrophoresis; In Vitro Techniques; Liver; Liver Extracts; NAD; NADP; Niacinamide; Nicotinic Acids; Nucleotides; Rats | 1970 |
Inhibition of corticosterone formation and 3 -hydroxysteroid dehydrogenase activity in cell-free preparations of rat adrenals.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Adrenal Glands; Aminophylline; Androstanes; Animals; Cell-Free System; Corticosterone; Cyclic AMP; Depression, Chemical; Drug Synergism; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Kinetics; Male; Microsomes; Mitochondria; NAD; NADP; Niacinamide; Pregnenolone; Rats | 1971 |
[Physiological effects of nicotinamide].
Topics: Chemical Phenomena; Chemistry; Coenzymes; Humans; Molecular Biology; NAD; NADP; Niacinamide; Nicotinic Acids; Oxidation-Reduction; Pyridines | 1971 |
Effect of nicotamide on the regulation of carbohydrate metabolism in rat liver.
Topics: Acetoacetates; Acetone; Adenine Nucleotides; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Carbohydrate Metabolism; Coenzyme A; Cytoplasm; Depression, Chemical; Fatty Acids, Nonesterified; Fructosephosphates; Gluconeogenesis; Glucose; Glucosephosphates; Glycerophosphates; Lactates; Lipid Metabolism; Liver; Liver Glycogen; Malates; Male; Metabolism; NAD; NADP; Niacinamide; Oxaloacetates; Phosphoenolpyruvate; Phosphoric Acids; Pyruvates; Rats; Time Factors; Triglycerides | 1970 |
Nicotinamide nucleotide synthesis in regenerating rat liver.
Topics: Animals; Cell Nucleus; DNA; Female; Hepatectomy; Injections, Intraperitoneal; Laparotomy; Liver; Liver Regeneration; NAD; NADP; Niacinamide; Nucleic Acids; Nucleotidyltransferases; Pentosyltransferases; Rats | 1971 |
Hyperproduction and purification of nicotinamide deamidase, a microconstitutive enzyme of Escherichia coli.
Topics: Amidohydrolases; Ammonium Sulfate; Carbon Isotopes; Chemical Precipitation; Chromatography, Gel; Culture Media; Drug Stability; Electrophoresis; Escherichia coli; Genes; Kinetics; Methods; Molecular Weight; Mutagens; Mutation; NAD; NADP; Niacinamide; Nitrosoguanidines; Stimulation, Chemical; Transduction, Genetic; Vibration | 1971 |
The effects of reduced nicotinamide adenine dinucleotide phosphate, its structural analogues, and coenzyme A and its derivatives on the rate of dissociation, conformation, and enzyme activity of the pigeon liver fatty acid synthetase complex.
Topics: Adenine Nucleotides; Animals; Binding Sites; Coenzyme A; Columbidae; Drug Stability; Edetic Acid; Fatty Acid Synthases; Fructosephosphates; Glycine; Hydrogen-Ion Concentration; Liver; Macromolecular Substances; NAD; NADP; Niacinamide; Osmolar Concentration; Potassium Chloride; Protein Conformation; Ribonucleotides; Tromethamine; Ultracentrifugation | 1971 |
Inhibition of 7- 14 C-nicotinic acid metabolism in the human blood platelet by anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents; Aspirin; Blood Platelets; Carbon Isotopes; Depression, Chemical; Flufenamic Acid; Humans; NAD; NADP; Niacinamide; Nicotinic Acids; Ribonucleotides | 1970 |
Coupled oxidoreductase activity of horse liver alcohol dehydrogenase.
Topics: Acetates; Alcohol Oxidoreductases; Alcohols; Aldehydes; Animals; Catalysis; Chemical Phenomena; Chemistry; Colorimetry; Enzyme Activation; Glyceraldehyde; Glycols; Horses; Kinetics; Liver; Mathematics; Methods; Models, Chemical; NAD; NADP; Niacinamide; Semicarbazides; Spectrophotometry; Structure-Activity Relationship | 1972 |
Studies on the mechanism and regulation of C-4 demethylation in cholesterol biosynthesis. The role of adenosine 3':5'-cyclic monophosphate.
Topics: Aerobiosis; Anaerobiosis; Animals; Carboxylic Acids; Cholestanes; Cholesterol; Cyclic AMP; Glutamate Dehydrogenase; Glutamates; Glutarates; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Ketosteroids; Methods; Methylation; Microsomes, Liver; NAD; NADP; Niacinamide; Rats; Sterols; Tritium | 1971 |
31 P and 13 C nuclear magnetic resonance studies of nicotinamide-adenine dinucleotide and related compounds.
Topics: Acetates; Adenine Nucleotides; Adenosine Monophosphate; Alcohol Oxidoreductases; Carbon Isotopes; Carbonates; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Isotope Labeling; Magnetic Resonance Spectroscopy; Methylation; N-Glycosyl Hydrolases; NAD; NADP; Niacinamide; Nicotinic Acids; Nucleoside Diphosphate Sugars; Nucleotides; Oxidation-Reduction; Phosphoric Diester Hydrolases; Phosphorus; Pyridines; Ribose | 1972 |
Inhibition of nicotinamide phosphoribosyltransferase by pyridine nucleotides.
Topics: Acetates; Animals; Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Paper; Computers; Fluorine; Hypoxanthines; Kinetics; Liver; Models, Chemical; NAD; NADP; Niacinamide; Nucleosides; Nucleotides; Oxidation-Reduction; Pentosephosphates; Pentosyltransferases; Pyridines; Rats; Ribose; Stereoisomerism; Structure-Activity Relationship; Sulfur | 1972 |
[Change in the indices of pyridoxine and nicotinic acid metabolism during physical loading].
Topics: Adolescent; Adult; Animals; Humans; Kidney; Liver; Muscles; NAD; NADP; Niacinamide; Physical Exertion; Pyridoxine; Rats; Seasons; Sports Medicine | 1972 |
Pyridine nucleotides in normal and nicotinamide depleted adrenal tumor cell cultures.
Topics: Acetates; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Animals; Azaserine; Cell Line; Cell Survival; Cells, Cultured; Culture Media; Cyclic AMP; Kinetics; Mice; NAD; NADP; Niacinamide; Pyridines; Spectrometry, Fluorescence; Spectrophotometry; Steroids; Ultraviolet Rays | 1972 |
Method for preparing NAD labeled with 3 H of high specific radioactivity in the 4-nicotinamide position.
Topics: Alkaline Phosphatase; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Glucosephosphate Dehydrogenase; Hexokinase; Isotope Labeling; L-Lactate Dehydrogenase; Methods; NAD; NADP; Niacinamide; Oxidation-Reduction; Time Factors; Tritium | 1972 |
Factors influencing placental steroidogenesis.
Topics: 17-Ketosteroids; Adenosine Triphosphate; Androstenes; Animals; Carbon Isotopes; Cholesterol; Chorionic Gonadotropin; Chromatography, Paper; Chromatography, Thin Layer; Countercurrent Distribution; Estradiol; Estrone; Female; Glucosephosphates; Humans; Immune Sera; Ketosteroids; NAD; NADP; Niacinamide; Placenta; Pregnancy; Pregnenolone; Progesterone; Rabbits; Tritium | 1972 |
Nicotinamide adenine dinucleotide glycohydrolases from Ehrlich ascites tumor cell nuclei: isolation, partial purification, and properties.
Topics: Adenine Nucleotides; Animals; Carcinoma, Ehrlich Tumor; Cell Membrane; Cell Nucleus; Centrifugation, Density Gradient; Deoxyribonucleases; Drug Stability; Hot Temperature; Hydrogen-Ion Concentration; Membranes; Mice; Microscopy, Electron; N-Glycosyl Hydrolases; NAD; NADP; Neoplasm Proteins; Niacinamide; Nucleoproteins; Nucleoside Diphosphate Sugars; Polynucleotides; Sodium Chloride; Ultracentrifugation | 1972 |
Nicotinamide adenine dinucleotide glycohydrolase activity in guinea pig polymorphonuclear leukocytes.
Topics: Albumins; Animals; Azides; Blood Proteins; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography; Cyanides; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Leukocytes; N-Glycosyl Hydrolases; NAD; NADP; Niacinamide; Time Factors | 1972 |
The control of nucleic acid and nicotinamide nucleotide synthesis in regenerating rat liver.
Topics: Adenosine Triphosphate; Animals; Carbon Isotopes; DNA; Ethionine; Female; Hepatectomy; Liver; Liver Regeneration; NAD; NADP; Niacinamide; Organophosphorus Compounds; Orotic Acid; Pentosephosphates; Phosphotransferases; Purine Nucleotides; Pyrimidine Nucleotides; Rats; Ribose; RNA | 1972 |
Nicotinamide inhibition of 3',5'-cyclic AMP phosphodiesterase in vitro.
Topics: Animals; Cattle; Cyclic AMP; Liver; Male; NAD; NADP; Niacinamide; Nicotinic Acids; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridines; Rats; Serum Albumin, Bovine; Snakes; Tritium; Venoms | 1972 |
Hymenolepis diminuta: absorption of nicotinamide.
Topics: Animals; Carbon Isotopes; Cestoda; Chromatography, Paper; Culture Media; Diffusion; Injections, Intraperitoneal; Male; NAD; NADP; Niacinamide; Nicotinic Acids; Rats | 1972 |
Bull semen nicotinamide adenine dinucleotide nucleosidase. V. Kinetic studies.
Topics: Adenine Nucleotides; Aldehydes; Animals; Binding, Competitive; Catalysis; Cattle; Drug Stability; Feedback; Hydrolysis; Hypoxanthines; Kinetics; Male; Mathematics; N-Glycosyl Hydrolases; NAD; NADP; Niacinamide; Nicotinamide Mononucleotide; Nucleotides; Pyridines; Ribonucleotides; Semen; Structure-Activity Relationship; Sulfides | 1973 |
Crystallographic investigations of nicotinamide adenine dinucleotide binding to horse liver alcohol dehydrogenase.
Topics: Adenine; Adenosine Diphosphate Ribose; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Binding Sites; Chemical Phenomena; Chemistry, Physical; Crystallography; Diphosphates; Liver; Molecular Conformation; NAD; Niacinamide; Nicotinamide Mononucleotide; Protein Conformation; Ribose | 1984 |
Convenient method for enzymic synthesis of [14C]nicotinamide riboside.
Topics: Amidohydrolases; Carbon Radioisotopes; Isotope Labeling; N-Glycosyl Hydrolases; NAD; Niacinamide; Nucleotidases; Proteus vulgaris; Pyridinium Compounds; Pyrophosphatases; Ribonucleosides | 1980 |
Enhancement by streptozotocin and N-methyl-N'-nitro-N-nitrosoguanidine of the tyrosine aminotransferase activity in cultured rat liver cells: role of dexamethasone and NAD.
Topics: Animals; Cells, Cultured; Dexamethasone; DNA; Enzyme Induction; Liver; Methylnitronitrosoguanidine; NAD; Niacinamide; Poly Adenosine Diphosphate Ribose; Rats; RNA; Streptozocin; Tyrosine Transaminase | 1980 |
Insulin and epidermal growth factor stimulate poly ADP-ribosylation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Epidermal Growth Factor; Fibroblasts; Insulin; Kinetics; Mice; Mice, Inbred BALB C; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Peptides; Poly Adenosine Diphosphate Ribose | 1981 |
Evidence for a physiologically active nicotinamide phosphoribosyltransferase in cultured human fibroblasts.
Topics: Adenosine Triphosphate; Cells, Cultured; Fibroblasts; Humans; Kinetics; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Pentosyltransferases; Phosphoribosyl Pyrophosphate | 1982 |
The differences in growth and activity of the tryptophan-NAD pathway between Wistar and Sprague Dawley strains of rats fed on tryptophan-limited diet.
Topics: Animals; Carboxy-Lyases; Growth; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; NAD; Niacin; Niacinamide; Nicotinic Acids; Quinolinic Acids; Rats; Rats, Inbred Strains; Species Specificity; Tryptophan; Tryptophan Oxygenase | 1982 |
Enhancement of DNA synthesis and cell proliferation by 1-methylnicotinamide in rat liver cells in culture: implication for its in vivo role.
Topics: Animals; Cell Division; Cells, Cultured; DNA Replication; Kinetics; Liver; NAD; Niacinamide; Poly Adenosine Diphosphate Ribose; Rats; Transcription, Genetic | 1982 |
Probable mechanisms of regulation of the utilization of dietary tryptophan, nicotinamide and nicotinic acid as precursors of nicotinamide nucleotides in the rat.
Topics: Animals; Diet; Liver; Male; NAD; Niacin; Niacinamide; Nicotinamidase; Nicotinic Acids; Pentosyltransferases; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan | 1982 |
Effect of L-leucine-supplemented diet on the nicotinamide adenine dinucleotide content of rat liver.
Topics: Animals; Diet; Dose-Response Relationship, Drug; Intestinal Absorption; Leucine; Liver; Male; NAD; Niacinamide; Nicotinic Acids; Pentosyltransferases; Rats; Rats, Inbred Strains; Tryptophan; Tryptophan Oxygenase | 1982 |
Conformation of NAD+ bound to yeast and horse liver alcohol dehydrogenase in solution. The use of the proton-proton transferred nuclear Overhauser enhancement.
Topics: Adenosine; Alcohol Oxidoreductases; Animals; Horses; Liver; Magnetic Resonance Spectroscopy; NAD; Niacinamide; Protein Conformation; Ribose; Yeasts | 1982 |
Protective effect of nicotinamide on bracken fern induced carcinogenicity in rats.
Topics: Animals; Body Weight; Female; Intestinal Neoplasms; Male; NAD; Neoplasms, Experimental; Niacinamide; Plants, Toxic; Rats; Rats, Inbred Strains; Urinary Bladder Neoplasms | 1981 |
Effect of L-tryptophan and L-leucine on biosynthesis of niacin-related compounds in Saccharomyces carlsbergensis.
Topics: Culture Media; Leucine; NAD; NADP; Niacin; Niacinamide; Nicotinamidase; Pentosyltransferases; Saccharomyces; Tryptophan | 1982 |
Nicotinamide inhibits adipocyte differentiation of 3T3-L1 cells.
Topics: Adenosine Diphosphate; Adipose Tissue; Animals; Cell Differentiation; Clone Cells; Fibroblasts; Mice; NAD; Niacinamide | 1982 |
Nucleoside salvage pathway for NAD biosynthesis in Salmonella typhimurium.
Topics: NAD; Niacinamide; Nicotinamide Mononucleotide; Phosphorylation; Pyridinium Compounds; Salmonella typhimurium | 1982 |
Reactivation of NAD(H) biosynthetic pathway by exogenous NAD+ in Nil cells severely depleted of NAD(H).
Topics: Animals; Cell Division; Cell Line; Cricetinae; DNA; Fibroblasts; Glucose; Interphase; Lactates; Lactic Acid; NAD; Niacin; Niacinamide; Nicotinamide Mononucleotide; Protein Biosynthesis | 1983 |
Digestion and absorption of NAD by the small intestine of the rat.
Topics: Animals; Digestion; Hydrolysis; Intestinal Absorption; Intestine, Small; Male; NAD; Niacinamide; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Isoniazid perturbation of the pyridine nucleotide cycle of Escherichia coli.
Topics: Escherichia coli; Isoniazid; Mutation; NAD; NADP; Niacin; Niacinamide; Nicotinamide Mononucleotide | 1982 |
Prevention possibility for brain dysfunction in rat with the fetal alcohol syndrome--low-zinc-status and hypoglycemia.
Topics: Animals; Brain; Carbonic Anhydrases; Central Nervous System Diseases; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Fetus; Glucose; Growth; Hypoglycemia; NAD; Niacinamide; Pregnancy; Rats; Rats, Inbred Strains; Sulfates; Zinc; Zinc Sulfate | 1982 |
Differential effects of NAD, nicotinamide and related compounds upon growth and nucleoside incorporation in human cells.
Topics: Adenosine; Cell Division; Cell Line; DNA Repair; DNA, Neoplasm; Fibroblasts; Humans; Melanoma; NAD; Neoplasms, Experimental; Niacinamide; Nucleosides; RNA, Neoplasm | 1983 |
6-Aminonicotinamide-resistant mutants of Salmonella typhimurium.
Topics: 6-Aminonicotinamide; Amino Acid Oxidoreductases; Drug Resistance, Microbial; Escherichia coli Proteins; Genes, Bacterial; Mutation; NAD; Niacinamide; Nicotinamidase; Nicotinamide-Nucleotide Adenylyltransferase; Salmonella typhimurium; Temperature | 1983 |
Cardiac synthesis and degradation of pyridine nucleotides and the level of energy-rich phosphates influenced by various precursors.
Topics: Adenine; Adenosine Triphosphate; Animals; Glycoside Hydrolases; Guinea Pigs; Hypoxia; Myocardial Contraction; Myocardium; NAD; Niacinamide; Nicotinic Acids; Ribose | 1983 |
Thin-layer chromatographic separation of intermediates of the pyridine nucleotide cycle.
Topics: Chromatography, Thin Layer; NAD; NADP; Niacinamide; Nicotinic Acids; Paramecium | 1983 |
Protection from DNA damage during an ischemic cell injury.
Topics: Animals; DNA; DNA Repair; Ischemia; Kidney; Male; Mice; NAD; Niacin; Niacinamide | 1983 |
Characteristics of nicotinamide and N1-methylnicotinamide protection from alloxan diabetes in mice.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; NAD; Niacinamide | 1983 |
Inhibitors of poly (ADP-ribose) synthesis enhance radiation response by differentially affecting repair of potentially lethal versus sublethal damage.
Topics: Animals; Benzamides; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose; Time Factors | 1984 |
ADP-ribosylation of isolated rat islets of Langerhans.
Topics: Adenosine Diphosphate Ribose; Animals; Arginine; Cell Membrane; In Vitro Techniques; Islets of Langerhans; Kinetics; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Rats; Rats, Inbred Lew; Theophylline; Tritium | 1984 |
Inhibition of tryptophan metabolism by oestrogens in the rat: a factor in the aetiology of pellagra.
Topics: Animals; Castration; Estrone; Female; Liver; NAD; NADP; Niacinamide; Pellagra; Rats; Rats, Inbred Strains; Tryptophan | 1984 |
N-nitrosodimethylamine carcinogenesis in nicotinamide-deficient rats.
Topics: Animals; Dimethylnitrosamine; Kidney; Kidney Neoplasms; Liver; Liver Neoplasms, Experimental; Male; NAD; NADP; Niacinamide; Oxidation-Reduction; Rats | 1984 |
Synthesis and properties of (4-13C)NAD+. Observation of its binding to yeast alcohol dehydrogenase by 13C-NMR spectroscopy.
Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Binding Sites; Carbon Isotopes; Catalysis; Chemical Phenomena; Chemistry; Isotope Labeling; Magnetic Resonance Spectroscopy; NAD; Niacin; Niacinamide; Protein Binding; Saccharomyces cerevisiae | 1984 |
Deprival of nicotinamide leads to enhanced glucose transport in chick embryo fibroblasts.
Topics: 3-O-Methylglucose; Animals; Biological Transport, Active; Cells, Cultured; Chick Embryo; Fibroblasts; Glucose; Kinetics; Methylglucosides; NAD; NADP; Niacinamide | 1984 |
Modulation of uterine sensitivity to decidual induction in the rat by nicotinamide; challenge and extension of a model of progestational differentiation.
Topics: Animals; Decidua; Embryo Implantation; Female; NAD; NADP; Niacinamide; Pregnancy; Progesterone; Rats | 1984 |
Acceleration of the NAD cyanide adduct reaction by lactate dehydrogenase: the equilibrium binding effect as a measure of the activation of bound NAD.
Topics: Animals; Cyanides; Dogfish; Enzyme Activation; Kinetics; L-Lactate Dehydrogenase; Mathematics; Models, Biological; NAD; Niacinamide; Protein Binding | 1984 |
Nicotinamide methylation and its relation to NAD synthesis in rat liver tissue culture. Biochemical basis for the physiological activities of 1-methylnicotinamide.
Topics: Adenosine Triphosphate; Animals; Carbon Radioisotopes; Cells, Cultured; Cytosol; Female; In Vitro Techniques; Kinetics; Liver; Methylation; NAD; Niacinamide; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1984 |
Nicotinamide does not protect islet B-cell metabolism against alloxan toxicity.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Mice; NAD; Niacinamide; Oxidation-Reduction; Oxygen Consumption; Proinsulin | 1984 |
Chemical mutation of enzyme active sites.
Topics: Anaerobiosis; Binding Sites; Catalysis; Chemical Phenomena; Chemistry; Chymotrypsin; Enzymes; Flavins; Kinetics; NAD; Niacinamide; Oxidation-Reduction; Papain; Stereoisomerism; Toluene | 1984 |
Potentiation of EPN-induced inhibition of liver microsomal carboxylesterase by addition of liver cytosol from 6-aminonicotinamide-treated, starved rats.
Topics: 6-Aminonicotinamide; Animals; Carboxylic Ester Hydrolases; Cytosol; In Vitro Techniques; Insecticides; Male; Microsomes, Liver; Mixed Function Oxygenases; NAD; NADP; Niacinamide; Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester; Rats; Rats, Inbred Strains; Starvation | 1984 |
Nicotinamide as a radiosensitizer of a C3H mouse mammary adenocarcinoma.
Topics: Adenocarcinoma; Animals; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; NAD; Niacinamide; Radiation-Sensitizing Agents | 1984 |
Conformational variability of NAD+ in the free and bound states: a nicotinamide sandwich in NAD+ crystals.
Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Animals; Geobacillus stearothermophilus; Glyceraldehyde-3-Phosphate Dehydrogenases; L-Lactate Dehydrogenase; Liver; Malate Dehydrogenase; Models, Molecular; Molecular Conformation; NAD; Nephropidae; Niacinamide; Protein Binding; X-Ray Diffraction | 1984 |
NAD (P) H-dependent reduction of nicotinamide N-oxide by an unique enzyme system consisting of liver microsomal NADPH-cytochrome C reductase and cytosolic aldehyde oxidase.
Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Animals; Cytosol; Electron Transport; Male; Microsomes, Liver; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Niacinamide; Rabbits | 1984 |
[Dependence of ADP-ribosylation of histones of chicken liver nuclei on the intranuclear content of NAD].
Topics: Animals; Cell Nucleus; Chickens; Histones; In Vitro Techniques; Liver; NAD; Niacinamide; Nicotinic Acids; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose | 1984 |
Isolation and properties of an NAD- and guanidine-dependent ADP-ribosyltransferase from turkey erythrocytes.
Topics: Animals; Erythrocytes; Guanidines; Kinetics; NAD; Niacinamide; Nucleotidyltransferases; Poly(ADP-ribose) Polymerases; Theophylline; Thymidine; Turkeys | 1980 |
NAD turnover in microplasmodia of physarum polycephalum.
Topics: NAD; NAD+ Nucleosidase; Niacinamide; Physarum | 1980 |
Identification of a nicotinamide adenine dinucleotide glycohydrolase and an associated inhibitor in isoniazid-susceptible and -resistant Mycobacterium phlei.
Topics: Chromatography, Gel; Drug Resistance, Microbial; Hot Temperature; Isoniazid; Mycobacterium; Mycobacterium phlei; NAD; NAD+ Nucleosidase; Niacinamide | 1980 |
Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets.
Topics: Amides; Animals; Cell Nucleus; Diabetes Mellitus, Experimental; Islets of Langerhans; Male; NAD; NAD+ Nucleosidase; Niacinamide; Picolinic Acids; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Proinsulin; Rats; Streptozocin | 1980 |
[Mechanism of action of vitamin PP and nicotinamide nucleotides on neuromuscular transmission in guinea pig taenia coli].
Topics: Animals; Colon; Electric Conductivity; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Muscle, Smooth; NAD; NADP; Neuromuscular Junction; Niacinamide; Oxidation-Reduction; Synaptic Transmission | 1980 |
Hormonal stimulation of eucaryotic cell ADP-ribosylation.
Topics: Adenosine Diphosphate Ribose; Animals; Bucladesine; Cells, Cultured; Dogs; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Proteins; Thymidine; Thyroid Gland; Thyrotropin | 1981 |
Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets.
Topics: Alloxan; Amides; Animals; DNA; Islets of Langerhans; Kinetics; NAD; NAD+ Nucleosidase; Niacinamide; Picolinic Acids; Poly(ADP-ribose) Polymerases; Proinsulin; Rats; Streptozocin | 1981 |
Apparent pyridine nucleotide synthesis in mitochondria: an artifact of NMN and NAD glycohydrolase activity?
Topics: Animals; Female; In Vitro Techniques; Microsomes, Liver; Mitochondria, Liver; N-Glycosyl Hydrolases; NAD; NAD+ Nucleosidase; Niacinamide; Nicotinamide Mononucleotide; Rats | 1981 |
Studies of Bungarus fasciatus venom NAD glycohydrolase. Inhibition, modification, and transglycosidation reactions.
Topics: Adenine Nucleotides; Animals; Binding, Competitive; Bungarotoxins; Kinetics; NAD; NAD+ Nucleosidase; Niacinamide | 1982 |
Poly(adenosinediphosphoribose) polymerase inhibitors stimulate unscheduled deoxyribonucleic acid synthesis in normal human lymphocytes.
Topics: Benzamides; DNA; DNA Repair; Humans; Lymphocytes; Methylnitronitrosoguanidine; NAD; NAD+ Nucleosidase; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Purines; Pyrazinamide | 1982 |
[Kinetic characteristics of microsomal NAD-glycohydrolase natural and solubilized with a non-ionic surface-active substance].
Topics: Animals; Isoelectric Focusing; Kinetics; Microsomes; NAD; NAD+ Nucleosidase; NADP; Niacinamide; Octoxynol; Polyethylene Glycols; Rats; Rats, Inbred Strains; Solubility; Spleen | 1982 |
NAD glycohydrolase activity in the liver of rats fed on excess leucine diet and low or high protein diet.
Topics: Animals; Body Weight; Dietary Proteins; Dose-Response Relationship, Drug; Leucine; Liver; Male; NAD; NAD+ Nucleosidase; Niacin; Niacinamide; Nicotinic Acids; Rats; Rats, Inbred Strains | 1982 |
The role of the nicotinamide moiety of NAd+ for negative cooperativity in glyceraldehyde-3-phosphate dehydrogenase as studied by spin-labeled cofactors.
Topics: Animals; Electron Spin Resonance Spectroscopy; Fishes; Glyceraldehyde-3-Phosphate Dehydrogenases; Muscles; NAD; Niacinamide; Protein Binding; Spin Labels | 1982 |
Pyridine nucleotide metabolism in the erythrocyte of South African blacks with primary hepatoma.
Topics: Black People; Carcinoma, Hepatocellular; Erythrocytes; Humans; Liver Neoplasms; Models, Biological; NAD; NADP; Niacin; Niacinamide; Nicotinamide Mononucleotide; South Africa | 1982 |
Influence of D-galactosamine upon the NAD-metabolism in rat liver.
Topics: Adrenalectomy; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Methionine; NAD; Niacinamide; Nucleotidyltransferases; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred Strains; Tryptophan | 1983 |
NAD+-dependent ADP-ribosyltransferase in renal brush-border membranes.
Topics: Animals; Cell Membrane; Cell Nucleus; Edetic Acid; Kidney Cortex; Kinetics; Magnesium; Male; Microvilli; NAD; Niacinamide; Nucleotidyltransferases; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred Strains; Thymidine | 1983 |
Poly(ADP-ribose) Polymerase inhibitors preserve nicotinamide adenine dinucleotide and adenosine 5'-triphosphate pools in DNA-damaged cells: mechanism of stimulation of unscheduled DNA synthesis.
Topics: Adenosine Triphosphate; Animals; Benzamides; Cells, Cultured; DNA; DNA Repair; DNA, Neoplasm; Leukemia L1210; Methylnitronitrosoguanidine; Mice; NAD; NAD+ Nucleosidase; Neoplasm Proteins; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; RNA, Neoplasm | 1983 |
Poly(ADP-ribose) polymerase mediates the suicide response to massive DNA damage: studies in normal and DNA-repair defective cells.
Topics: Adenosine Triphosphate; Animals; DNA Repair; Humans; In Vitro Techniques; Leukemia L1210; Methylnitronitrosoguanidine; NAD; NAD+ Nucleosidase; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases | 1983 |
Preliminary evidence for a pyridine nucleotide cycle in Bordetella pertussis.
Topics: Bordetella pertussis; NAD; Niacin; Niacinamide; Nicotinamidase; Nicotinamide Mononucleotide | 1984 |
Photochemical redox transformations of dimers of NAD+ and N'-methylnicotinamide.
Topics: NAD; Niacinamide; Oxidation-Reduction; Photochemistry; Polarography; Snake Venoms; Ultraviolet Rays | 1980 |
The one-electron reduction potentials of NAD.
Topics: Electrons; Free Radicals; Kinetics; NAD; Niacinamide; Oxidation-Reduction; Potentiometry | 1980 |
Energetics of the one-electron steps in the NAD+/NADH redox couple.
Topics: Electrons; Kinetics; NAD; Niacinamide; Oxidation-Reduction; Potentiometry | 1980 |
[Nicotinamide as an inhibitor of gluconeogenesis from pyruvate in perfused rat liver].
Topics: Animals; Depression, Chemical; Gluconeogenesis; Lactates; Liver; Malates; Male; NAD; Niacinamide; Oxidation-Reduction; Perfusion; Phosphoenolpyruvate; Pyruvates; Rats | 1980 |
Effect of hepatocyte culture conditions on their content of nicotinamide coenzymes [proceedings].
Topics: Animals; Cells, Cultured; Liver; NAD; Niacinamide; Nicotinic Acids; Rats | 1980 |
Isolation and analysis of pyridine nucleotides and related compounds by liquid chromatography.
Topics: Adenine Nucleotides; Chromatography, Ion Exchange; NAD; NADP; Niacinamide; Nicotinic Acids; Ribonucleotides; Spectrophotometry, Ultraviolet | 1980 |
Fluorometric quantitation of picomole amounts of 1-methylnicotinamide and nicotinamide in serum.
Topics: Animals; Humans; Microchemistry; NAD; NADP; Niacinamide; Rats; Spectrometry, Fluorescence | 1980 |
Long-term perturbation of pyridine nucleotides in rat liver.
Topics: Animals; Female; Kinetics; Liver; Male; NAD; NADP; Niacinamide; Oxidation-Reduction; Rats; Sex Factors; Time Factors | 1980 |
Increase of mono(ADP-ribose) protein conjugate levels in rat liver induced by nicotinamide administration.
Topics: Adenosine Diphosphate Ribose; Animals; Hydroxylamines; Liver; Liver Neoplasms, Experimental; NAD; NADP; Niacinamide; Nucleoside Diphosphate Sugars; Oxidation-Reduction; Protein Binding; Proteins; Rats | 1980 |
Pyridine nucleotide cycle of Salmonella typhimurium: in vivo recycling of nicotinamide adenine dinucleotide.
Topics: Amidohydrolases; Mutation; N-Glycosyl Hydrolases; NAD; Niacinamide; Nicotinamidase; Nicotinamide Mononucleotide; Nicotinic Acids; Salmonella typhimurium | 1980 |
Oxidation of dihydronicotinamides by flavin in enzyme and model reactions. Old yellow enzyme and lumiflavin.
Topics: Aerobiosis; Flavins; Kinetics; Models, Biological; NAD; NADH, NADPH Oxidoreductases; NADP; NADPH Dehydrogenase; Niacinamide; Oxidation-Reduction; Saccharomyces cerevisiae | 1980 |
Requirement for guanosine triphosphate for cholera-toxin-catalysed incorporation of adenosine diphosphate ribose into rat liver plasma membranes and for activation of adenylate cyclase.
Topics: Adenosine Diphosphate Ribose; Adenosine Triphosphate; Adenylyl Cyclases; Animals; Cell Membrane; Cholera Toxin; Enzyme Activation; Female; Guanosine Triphosphate; In Vitro Techniques; Liver; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Rats | 1980 |
Metabolism of NAD and N1-methylnicotinamide in growing and growth-arrested cells.
Topics: Animals; Blood; Cell Division; Cells, Cultured; Culture Media; Kidney; Kinetics; NAD; Niacinamide; Rats | 1980 |
Possible role of nicotinamide adenine dinucleotide as an intracellular regulator of renal transport of phosphate in the rat.
Topics: Adenosine; Animals; Biological Transport, Active; Cell-Free System; Diet; Glucose; Kidney Cortex; Kidney Tubules, Proximal; Microvilli; NAD; Niacinamide; Phosphates; Rats; Sodium | 1981 |
1-methylnicotinamide and NAD metabolism in normal and transformed normal rat kidney cells.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Kidney; NAD; Niacinamide; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1981 |
Effects of nicotinamide on NAD and poly(ADP-ribose) metabolism in DNA-damaged human lymphocytes.
Topics: DNA Repair; DNA Replication; Humans; Kinetics; Lymphocytes; Methylnitronitrosoguanidine; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose | 1981 |
Ethionine alters the urinary excretion of N1-methylnicotinamide.
Topics: Animals; Ethionine; Liver; Male; Methylation; Methyltransferases; NAD; Niacinamide; Rats; Time Factors | 1981 |
Amplification of pyridine nucleotide pools in mitogen-stimulated human lymphocytes.
Topics: Biological Transport; Humans; Kinetics; Lymphocyte Activation; Lymphocytes; NAD; NADP; Niacinamide; Oxidation-Reduction; Phytohemagglutinins | 1982 |
Mechanism of inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol.
Topics: Adenosine Diphosphate; Adenosine Diphosphate Ribose; Binding, Competitive; Enzyme Inhibitors; Glycoside Hydrolases; Kinetics; Molecular Structure; NAD; Niacinamide; Pyrrolidines | 1995 |
Different basal NAD levels determine opposite effects of poly(ADP-ribosyl)polymerase inhibitors on H2O2-induced apoptosis.
Topics: Apoptosis; Benzamides; Cell Death; Cell Line; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Kinetics; Monocytes; NAD; Niacinamide; Oxidative Stress; Poly(ADP-ribose) Polymerase Inhibitors | 1995 |
Interrelationship of changes in islet nicotine adeninedinucleotide, insulin secretion, and cell viability induced by interleukin-1 beta.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Arginine Vasopressin; beta-Endorphin; Cell Survival; Cells, Cultured; Colforsin; Corticosterone; Dynorphins; Glucose; Insulin; Insulin Secretion; Interleukin-1; Islets of Langerhans; Kinetics; Male; NAD; Niacinamide; Nitric Oxide Synthase; omega-N-Methylarginine; Probucol; Progesterone; Rats; Vitamin E | 1994 |
Nicotinamide decreases nitric oxide production and partially protects human pancreatic islets against the suppressive effects of combinations of cytokines.
Topics: Adult; Diabetes Mellitus, Type 1; DNA; Drug Interactions; Humans; Insulin; Insulin Secretion; Interferon-gamma; Interleukin-1; Islets of Langerhans; Middle Aged; NAD; Niacinamide; Nitric Oxide; Recombinant Proteins; Tumor Necrosis Factor-alpha | 1994 |
HIV infection decreases intracellular nicotinamide adenine dinucleotide [NAD].
Topics: Cell Line; Cells, Cultured; HIV Infections; HIV-1; Humans; Lymphocyte Activation; Lymphocytes; NAD; Niacinamide; Rhabdomyosarcoma; Species Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virus Replication | 1995 |
Nicotinamide megadosing increases hepatic poly(ADP-ribose) levels in choline-deficient rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Choline; Choline Deficiency; Disease Models, Animal; Dose-Response Relationship, Drug; Food, Fortified; Liver; Male; Methionine; NAD; Niacinamide; Poly Adenosine Diphosphate Ribose; Random Allocation; Rats; Rats, Inbred F344 | 1995 |
Inhibition of poly(ADP-ribose) polymerase preserves surfactant synthesis after hydrogen peroxide exposure.
Topics: Adenosine Triphosphate; Animals; Benzamides; Deoxyglucose; Free Radical Scavengers; Hydrogen Peroxide; NAD; Niacinamide; Phosphatidylcholines; Poly(ADP-ribose) Polymerase Inhibitors; Pulmonary Alveoli; Pulmonary Surfactants; Rabbits | 1995 |
Involvement of NAD-poly(ADP-ribose) metabolism in p53 regulation and its consequences.
Topics: Animals; Apoptosis; Cells, Cultured; Cricetinae; Cricetulus; Etoposide; Fibroblasts; Humans; Luciferases; NAD; Niacinamide; Poly Adenosine Diphosphate Ribose; Transcription, Genetic; Tumor Suppressor Protein p53; Up-Regulation | 1995 |
[Basic and salvage pathways of NAD biosynthesis in organs of normal rats, tumor-bearing rats and in tumors].
Topics: Animals; Carcinoma 256, Walker; Enzyme Precursors; Kidney; Liver; Lymphoma, Non-Hodgkin; NAD; Neoplasms, Experimental; Niacin; Niacinamide; Quinolinic Acid; Rats | 1994 |
Structural studies on corn nitrate reductase: refined structure of the cytochrome b reductase fragment at 2.5 A, its ADP complex and an active-site mutant and modeling of the cytochrome b domain.
Topics: Adenosine Diphosphate; Amino Acid Sequence; Animals; Binding Sites; Crystallization; Cytochrome Reductases; Electron Transport; Flavin-Adenine Dinucleotide; Models, Molecular; Molecular Sequence Data; NAD; Niacinamide; Nitrate Reductases; Peptide Fragments; Point Mutation; Protein Conformation; Pyridinium Compounds; Recombinant Proteins; Zea mays | 1995 |
Pyridine nucleotide hydrolysis and interconversion in rat hepatocytes during oxidative stress.
Topics: Animals; Cells, Cultured; Enzyme Activation; Liver; Male; NAD; Naphthoquinones; Niacinamide; Oxidative Stress; Peroxides; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Wistar; tert-Butylhydroperoxide | 1995 |
Large supplements of nicotinic acid and nicotinamide increase tissue NAD+ and poly(ADP-ribose) levels but do not affect diethylnitrosamine-induced altered hepatic foci in Fischer-344 rats.
Topics: Adenosine Diphosphate Ribose; Animals; Diethylnitrosamine; Food, Fortified; Glutathione Transferase; Kidney; Liver; Lung; Male; Myocardium; NAD; Niacin; Niacinamide; Rats; Rats, Inbred F344 | 1995 |
Analysis of oxygen radical toxicity in pancreatic islets at the single cell level.
Topics: Animals; Cell Death; Cell Survival; Cells, Cultured; DNA Damage; Fluorescent Antibody Technique; Hypoxanthine; Hypoxanthines; Islets of Langerhans; Kinetics; NAD; Niacinamide; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Reactive Oxygen Species; Xanthine Oxidase | 1994 |
Metabolism of cyclic ADP-ribose in opossum kidney renal epithelial cells.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Biological Assay; Calcium; Carrier Proteins; Cell Line; Cell Membrane Permeability; Cyclic ADP-Ribose; Epithelium; Kidney; N-Glycosyl Hydrolases; NAD; Niacinamide; Opossums; Ovum; Parathyroid Hormone; Sea Urchins; Sodium-Phosphate Cotransporter Proteins; Symporters | 1995 |
Possible mechanisms involved in tumor radiosensitization following nicotinamide administration.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Blood Pressure; Glucose; Kidney; Lactates; Liver; Male; Muscles; NAD; Niacinamide; Oxygen; Oxyhemoglobins; Radiation-Sensitizing Agents; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sarcoma, Experimental | 1994 |
Nuclear response of pancreatic islets to interleukin-1 beta.
Topics: Adenine; Animals; Cell Nucleus; Cells, Cultured; Culture Media; DNA; DNA Damage; Interleukin-1; Islets of Langerhans; Magnesium; Male; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Recombinant Proteins; Time Factors | 1994 |
An ADP-ribosyltransferase as a potential target for nitric oxide action in hippocampal long-term potentiation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cyclic GMP; Dibutyryl Cyclic GMP; Evoked Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Molsidomine; N-Methylaspartate; NAD; Niacinamide; Nitric Oxide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1994 |
Failure to observe a relationship between bis-(beta-chloroethyl)sulfide-induced NAD depletion and cytotoxicity in the rat keratinocyte culture.
Topics: Animals; Cell Differentiation; Cell Division; Cell Survival; Cells, Cultured; DNA; Keratinocytes; Mustard Gas; NAD; Niacinamide; Rats; Time Factors | 1994 |
Synthesis of isosteric analogues of nicotinamide adenine dinucleotide containing C-nucleotide of nicotinamide or picolinamide.
Topics: Alcohol Dehydrogenase; Animals; Antimetabolites, Antineoplastic; Cattle; Glutamate Dehydrogenase; Horses; IMP Dehydrogenase; Leukemia L1210; Liver; Mice; NAD; Niacinamide; Picolinic Acids; Ribonucleosides | 1993 |
Nitric oxide toxicity in islet cells involves poly(ADP-ribose) polymerase activation and concomitant NAD+ depletion.
Topics: 1-Naphthylamine; Animals; Benzamides; Cell Survival; Cells, Cultured; DNA Damage; Enzyme Activation; Islets of Langerhans; Kinetics; NAD; Naphthalimides; Niacinamide; Nitric Oxide; Penicillamine; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinolones; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Time Factors | 1994 |
Dependence on NADH produced during glycolysis for beta-cell glucose signaling.
Topics: Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Cytosol; Glucose; Glyceraldehyde 3-Phosphate; Glycolysis; Islets of Langerhans; Kinetics; Membrane Potentials; Mice; Mice, Inbred C57BL; Models, Biological; NAD; Niacinamide; Potassium Channels; Signal Transduction | 1994 |
Quantitative efficacy of niacin sources for chicks: nicotinic acid, nicotinamide, NAD and tryptophan.
Topics: Analysis of Variance; Animal Feed; Animals; Biological Assay; Chickens; Dose-Response Relationship, Drug; Eating; Liver; Male; Muscles; NAD; NADP; Niacin; Niacinamide; Regression Analysis; Tryptophan; Weight Gain | 1993 |
Pathogenesis of 2,2'-dichlorodiethyl sulfide in hairless guinea pigs.
Topics: Animals; Blister; Drug Interactions; Guinea Pigs; Male; Mustard Gas; NAD; NADP; Niacinamide; Skin | 1993 |
Structural prototypes for an extended family of flavoprotein reductases: comparison of phthalate dioxygenase reductase with ferredoxin reductase and ferredoxin.
Topics: Amino Acid Sequence; Anabaena; Ferredoxin-NADP Reductase; Ferredoxins; Flavins; Flavoproteins; Glutathione Reductase; Iron-Sulfur Proteins; Models, Molecular; Molecular Sequence Data; NAD; NADP; Niacinamide; Oxidation-Reduction; Oxidoreductases; Potentiometry; Sequence Alignment; Sequence Homology, Amino Acid; Vegetables | 1993 |
Nicotinamide analogs and DNA-damaging agents deplete thyroid hormone receptor and c-erbA mRNA levels in pituitary GH1 cells.
Topics: Adenosine Diphosphate Ribose; Animals; Cell Line; DNA Damage; Enzyme Activation; Gene Expression; NAD; Niacinamide; Pituitary Gland; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Pyridines; Rats; Receptors, Thyroid Hormone; RNA, Messenger | 1993 |
Specific binding and uptake of extracellular nicotinamide in human leukemic K-562 cells.
Topics: Binding, Competitive; Carbon Radioisotopes; Cell Membrane; Cell Nucleus; Humans; Leukemia; NAD; Niacinamide; Time Factors; Tumor Cells, Cultured | 1993 |
Wide distribution of an enzyme that catalyzes the hydrolysis of cyclic ADP-ribose.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Brain; Calcium; Chick Embryo; Cyclic ADP-Ribose; Dogs; Hydrogen-Ion Concentration; Models, Chemical; N-Glycosyl Hydrolases; NAD; Niacinamide; Sea Urchins | 1993 |
Radical formation site of cerebral complex I and Parkinson's disease.
Topics: Animals; Brain; Cattle; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Hydroxyl Radical; Lipid Peroxidation; Mitochondria; NAD; NAD(P)H Dehydrogenase (Quinone); Niacinamide; Paraquat; Parkinson Disease; Reactive Oxygen Species; Superoxide Dismutase; Superoxides | 1995 |
[Effect of glucose and glutamine on the intensity of NAD precursor use in rats with transplanted tumors].
Topics: Animals; Carcinoma 256, Walker; Glucose; Glutamine; Kidney; Liver; Lymphoma, Non-Hodgkin; NAD; Neoplasm Transplantation; Niacin; Niacinamide; Rats | 1995 |
Increase of blood NAD+ and attenuation of lactacidemia during nicotinamide treatment of a patient with the MELAS syndrome.
Topics: Aged; Anticonvulsants; Carbamazepine; Cells, Cultured; Cerebrovascular Disorders; Epilepsy; Fibroblasts; Humans; Kinetics; Lactates; Male; MELAS Syndrome; Mitochondria, Muscle; NAD; NAD(P)H Dehydrogenase (Quinone); Niacinamide; Oxygen Consumption; Skin | 1996 |
Lactate stimulation of macrophage-derived angiogenic activity is associated with inhibition of Poly(ADP-ribose) synthesis.
Topics: Animals; Cells, Cultured; Cornea; Lactates; Lactic Acid; Macrophages; NAD; Neovascularization, Physiologic; Niacinamide; Oxidation-Reduction; Poly Adenosine Diphosphate Ribose; Rabbits | 1996 |
Nitric oxide-induced mobilization of intracellular calcium via the cyclic ADP-ribose signaling pathway.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Calcium; Cyclic ADP-Ribose; Cyclic GMP; Enzyme Inhibitors; Female; Guanosine Triphosphate; Isomerism; Kinetics; Mammals; Models, Biological; N-Glycosyl Hydrolases; NAD; Niacinamide; Nitric Oxide; Ovum; Sea Urchins; Signal Transduction; Thionucleotides; Time Factors | 1996 |
Nicotinamide methylation and hepatic energy reserve: a study by liver perfusion in vitro.
Topics: Adenosine Triphosphate; Animals; In Vitro Techniques; Liver; Methylation; NAD; Niacinamide; Perfusion; Rats; Rats, Sprague-Dawley | 1995 |
DNA damage and repair in tumour and non-tumour tissues of mice induced by nicotinamide.
Topics: Animals; DNA; DNA Damage; DNA Repair; Mice; Mice, Inbred CBA; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1996 |
Protective effects of nicotinamide against nitric oxide-mediated delayed vascular failure in endotoxic shock: potential involvement of polyADP ribosyl synthetase.
Topics: ADP Ribose Transferases; Animals; Blood Pressure; Energy Metabolism; Enzyme Activation; Heart Rate; Lipopolysaccharides; Macrophages; Male; Mitochondria; NAD; Niacinamide; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Rats; Rats, Wistar; Shock, Septic; Vascular Resistance | 1996 |
Nicotinamide as a precursor for NAD+ prevents apoptosis in the mouse brain induced by tertiary-butylhydroperoxide.
Topics: Animals; Apoptosis; Brain; DNA; DNA Repair; Immunohistochemistry; Injections, Intraventricular; Mice; Mice, Inbred C57BL; NAD; Nerve Degeneration; Niacinamide; Oxidative Stress; Peroxides; Poly(ADP-ribose) Polymerases; tert-Butylhydroperoxide | 1996 |
Direct thyroid hormone signalling via ADP-ribosylation controls mitochondrial nucleotide transport and membrane leakiness by changing the conformation of the adenine nucleotide transporter.
Topics: Adenine Nucleotides; Adenosine Diphosphate Ribose; Allosteric Regulation; Animals; Calcium; Electrophoresis, Polyacrylamide Gel; Hypothyroidism; Intracellular Membranes; Male; Membrane Proteins; Mitochondria, Liver; Mitochondrial ADP, ATP Translocases; NAD; Niacinamide; Permeability; Poly(ADP-ribose) Polymerases; Protein Conformation; Rats; Rats, Sprague-Dawley; Triiodothyronine | 1996 |
The cyclic GMP-mediated calcium release pathway in sea urchin eggs is not required for the rise in calcium during fertilization.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Calcium; Calcium Channels; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic IMP; Female; Fertilization; Kinetics; Male; Models, Biological; Muscle Proteins; N-Glycosyl Hydrolases; NAD; Niacinamide; Oocytes; Ryanodine Receptor Calcium Release Channel; Sea Urchins; Spermatozoa; Spermine; Thionucleotides | 1996 |
Fluorescence of reduced nicotinamides using one- and two-photon excitation.
Topics: Absorptiometry, Photon; Anisotropy; Fluorescence; Fluorescent Dyes; NAD; Niacinamide; Nicotinamide Mononucleotide; Oxidation-Reduction; Spectrometry, Fluorescence | 1996 |
Increased conversion ratio of tryptophan to niacin by the administration of clofibrate, a hypolipidemic drug, to rats.
Topics: Animals; Clofibrate; Hypolipidemic Agents; Liver; Male; NAD; Niacin; Niacinamide; Rats; Rats, Wistar; Tryptophan; Weaning; Weight Gain | 1996 |
Relative activity of N-(beta-D-glucopyranosyl)nicotinic acid to nicotinic acid as a niacin nutrient in rats and in Lactobacillus plantarum ATCC 8014.
Topics: Animals; Body Weight; Glucose; Lactobacillus; Male; NAD; Niacin; Niacinamide; Nicotinic Acids; Rats; Rats, Wistar | 1996 |
The conformation of NAD+ bound to lactate dehydrogenase determined by nuclear magnetic resonance with suppression of spin diffusion.
Topics: Adenosine; Animals; Crystallography, X-Ray; Dogfish; L-Lactate Dehydrogenase; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Conformation; NAD; Niacinamide; Ribose | 1997 |
Determining NAD synthesis in erythrocytes.
Topics: Adenine Nucleotides; Amide Synthases; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Ligases; NAD; Niacin; Niacinamide; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Nicotinamide-Nucleotide Adenylyltransferase; Nucleotidyltransferases; Pentosyltransferases | 1997 |
Detection and identification of NAD-catabolizing activities in rat tissue homogenates.
Topics: Adenosine Diphosphate Ribose; Adenosine Monophosphate; Animals; Detergents; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Kidney Cortex; Male; Molecular Weight; NAD; NAD+ Nucleosidase; Niacinamide; Nicotinamide Mononucleotide; Pyrophosphatases; Rats; Rats, Wistar; Spleen; Zinc | 1997 |
Increased brain NAD prevents neuronal apoptosis in vivo.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; Brain; DNA Fragmentation; Electron Spin Resonance Spectroscopy; Free Radicals; Immunohistochemistry; Mice; Mice, Inbred C57BL; NAD; Neurons; Niacinamide; Substantia Nigra | 1997 |
Inhibitory effect of nicotinamide to paraquat toxicity and the reaction site on complex I.
Topics: Animals; Binding Sites; Electrophoresis, Polyacrylamide Gel; Ferricyanides; Herbicides; Lipid Peroxidation; Liver; Lung; Male; NAD; NAD(P)H Dehydrogenase (Quinone); Niacinamide; Oxidation-Reduction; Paraquat; Rats; Rats, Sprague-Dawley; Submitochondrial Particles | 1997 |
Nicotinamide counteracts alcohol-induced impairment of hepatic protein metabolism in humans.
Topics: Adult; Albumins; Alcohol Drinking; Blood Glucose; Body Mass Index; Drug Interactions; Ethanol; Female; Fibrinogen; Humans; Immunoglobulin G; Insulin; Lactates; Leucine; Liver; Male; NAD; Niacinamide; Oxidation-Reduction; Proteins; Pyruvates | 1997 |
The effects of niacin on DNA repair after N-methyl-N'-nitro-N-nitrosoguanidine treatment in normal human lymphocytes.
Topics: Carcinogens; DNA; DNA Repair; Dose-Response Relationship, Drug; Humans; Methylnitronitrosoguanidine; NAD; Niacin; Niacinamide; Poly(ADP-ribose) Polymerases; T-Lymphocytes | 1997 |
Inhibitor and NAD+ binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Chickens; Crystallization; Crystallography, X-Ray; Diphtheria Toxin; Isoquinolines; Models, Molecular; Molecular Sequence Data; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Binding; Sequence Homology, Amino Acid | 1998 |
Murine glial cells regenerate NAD, after peroxide-induced depletion, using either nicotinic acid, nicotinamide, or quinolinic acid as substrates.
Topics: Animals; Hydrogen Peroxide; NAD; Neuroglia; Niacin; Niacinamide; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Substrate Specificity | 1998 |
DNA-damage and NAD(+)-depletion are initial events in oxygen radical induced islet cell death.
Topics: Animals; Cell Death; Cell Survival; Cells, Cultured; DNA Damage; Hypoxanthine; Islets of Langerhans; NAD; Niacinamide; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Reactive Oxygen Species; Xanthine Oxidase | 1997 |
The mechanism of the elongation and branching reaction of poly(ADP-ribose) polymerase as derived from crystal structures and mutagenesis.
Topics: Adenosine Diphosphate Ribose; Animals; Binding Sites; Chickens; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Mutagenesis; NAD; Niacinamide; Peptide Fragments; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Structure-Activity Relationship | 1998 |
Fragment-based modeling of NAD binding to the catalytic subunits of diphtheria and pertussis toxins.
Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Diphtheria Toxin; Models, Chemical; Models, Molecular; Molecular Sequence Data; Monte Carlo Method; NAD; Niacinamide; Protein Binding; Structure-Activity Relationship; Virulence Factors, Bordetella | 1998 |
[Effect of modulators of energy metabolism on cyclophosphane toxicity for Daphnia magna].
Topics: Alkylating Agents; Amino Acids; Animals; Biological Transport; Citric Acid; Cyclophosphamide; Daphnia; Energy Metabolism; Glucose; NAD; Niacinamide; Pyruvic Acid; Succinic Acid | 1998 |
Peroxynitrate-mediated DNA strand breakage activates poly(ADP-ribose) synthetase and causes cellular energy depletion in a nonseptic shock model induced by zymosan in the rat.
Topics: Animals; Benzamides; Disease Models, Animal; DNA Damage; Energy Metabolism; Enzyme Activation; Macrophages, Peritoneal; Male; Mitochondria; NAD; NG-Nitroarginine Methyl Ester; Niacinamide; Nitrates; Nitric Oxide Synthase; Oxidants; Oxygen Consumption; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Shock; Zymosan | 1998 |
Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes.
Topics: Alanine; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Animals; Binding Sites; Coenzymes; Crystallography, X-Ray; Horses; Ligands; Liver; Models, Molecular; NAD; Niacinamide; Phenylalanine; Structure-Activity Relationship; Substrate Specificity; Tryptophan; Valine | 1998 |
Enhancement of brain choline levels by nicotinamide: mechanism of action.
Topics: Animals; Brain; Choline; Hippocampus; In Vitro Techniques; Injections, Subcutaneous; Liver; Male; NAD; Niacinamide; Rats; Rats, Wistar; Time Factors | 1998 |
The reaction mechanism for CD38. A single intermediate is responsible for cyclization, hydrolysis, and base-exchange chemistries.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Antigens, CD; Antigens, Differentiation; Binding, Competitive; Catalysis; Cyclic ADP-Ribose; Fluorescence Polarization; Guanosine Diphosphate Sugars; Humans; Hydrolysis; Kinetics; Membrane Glycoproteins; Methanol; NAD; NAD+ Nucleosidase; Niacinamide; Nicotinamide Mononucleotide; Spectrometry, Fluorescence; Substrate Specificity | 1998 |
ADP-ribose gates the fertilization channel in ascidian oocytes.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Cell Membrane Permeability; Chelating Agents; Ciona intestinalis; Egtazic Acid; Electric Conductivity; Female; Fertilization; In Vitro Techniques; Ion Channel Gating; Ion Channels; Membrane Potentials; NAD; NADP; Niacinamide; Oocytes; Patch-Clamp Techniques; Sodium | 1998 |
The involvement of poly(ADP-ribose) polymerase in the oxidative stress responses in plants.
Topics: Apoptosis; Arabidopsis; Benzamides; Blotting, Western; Calcium; Cells, Cultured; DNA Repair; Glycine max; Hydrogen Peroxide; In Situ Nick-End Labeling; Ionophores; NAD; Niacinamide; Oxidative Stress; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Promoter Regions, Genetic; RNA, Antisense; Time Factors; Transformation, Genetic | 1998 |
The NAD+ precursors, nicotinic acid and nicotinamide upregulate glyceraldehyde-3-phosphate dehydrogenase and glucose-6-phosphate dehydrogenase mRNA in Jurkat cells.
Topics: Gene Expression Regulation, Enzymologic; Glucosephosphate Dehydrogenase; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Jurkat Cells; NAD; Niacin; Niacinamide; Oxidative Stress; Protein Precursors; RNA, Messenger; Up-Regulation | 1999 |
[Effect of chronic morphine administration on NAD and GABA-benzodiazepine complex receptors in synaptic membranes].
Topics: Animals; GABA Agonists; In Vitro Techniques; Male; Morphine; Muscimol; NAD; Narcotics; Niacinamide; Rats; Receptors, GABA-A; Synaptic Membranes | 1999 |
Magnetic resonance detects metabolic changes associated with chemotherapy-induced apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Caspases; Cell Survival; Colorectal Neoplasms; Dihydroxyacetone Phosphate; Doxorubicin; Fructosediphosphates; Glycerophosphates; Humans; Iodoacetates; Leukemia L1210; Magnetic Resonance Spectroscopy; Mechlorethamine; NAD; Niacinamide; Tumor Cells, Cultured | 1999 |
Synthesis of NAADP and cADPR in mitochondria.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Cell Compartmentation; Cell Membrane; Cyclic ADP-Ribose; Dithiothreitol; Glycosylphosphatidylinositols; Guanine Nucleotides; Isoenzymes; Membrane Glycoproteins; Mitochondria, Liver; Multienzyme Complexes; NAD; NAD+ Nucleosidase; NADP; Niacinamide; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Rats; Rats, Sprague-Dawley; Type C Phospholipases | 1999 |
Evidence for increased de novo synthesis of NAD in immune-activated RAW264.7 macrophages: a self-protective mechanism?
Topics: Animals; Benzamides; Cell Line; Dexamethasone; Enzyme Inhibitors; Interferon-gamma; Macrophage Activation; Macrophages; Mice; NAD; NG-Nitroarginine Methyl Ester; Niacinamide; Nitric Oxide Synthase; Poly(ADP-ribose) Polymerase Inhibitors; Quinolinic Acid; Recombinant Proteins; Tryptophan; Tryptophan Oxygenase | 1999 |
D-amphetamine-induced depletion of energy and dopamine in the rat striatum is attenuated by nicotinamide pretreatment.
Topics: Animals; Corpus Striatum; Dextroamphetamine; Dopamine; Energy Metabolism; Male; NAD; Niacinamide; Rats; Rats, Sprague-Dawley | 1999 |
cADP-ribose potentiates cytosolic Ca2+ elevation and Ca2+ entry via L-type voltage-activated Ca2+ channels in NG108-15 neuronal cells.
Topics: Adenosine Diphosphate Ribose; Biological Transport; Calcium; Calcium Channels, L-Type; Cells, Cultured; Cyclic ADP-Ribose; Cytosol; Ion Channel Gating; Manganese; Membrane Potentials; Models, Biological; NAD; Neurons; Niacinamide; Nifedipine; Patch-Clamp Techniques; Ryanodine; Ryanodine Receptor Calcium Release Channel; Tacrolimus | 2000 |
Competition between C-terminal tyrosine and nicotinamide modulates pyridine nucleotide affinity and specificity in plant ferredoxin-NADP(+) reductase.
Topics: Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Binding, Competitive; Chloroplasts; Ferredoxin-NADP Reductase; Hydrogen Bonding; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; NADP; Niacinamide; Pisum sativum; Protein Conformation; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tyrosine | 2000 |
The NAD+ precursors, nicotinic acid and nicotinamide protect cells against apoptosis induced by a multiple stress inducer, deoxycholate.
Topics: Apoptosis; Carrier Proteins; Cell Division; Deoxycholic Acid; Detergents; Endoplasmic Reticulum Chaperone BiP; Enzyme Precursors; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenases; Heat-Shock Proteins; HT29 Cells; Humans; Jurkat Cells; Molecular Chaperones; NAD; NF-kappa B; Niacin; Niacinamide; Oxidative Stress | 2000 |
Zinc-induced cortical neuronal death: contribution of energy failure attributable to loss of NAD(+) and inhibition of glycolysis.
Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Dihydroxyacetone Phosphate; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; Mice; NAD; Neurons; Niacinamide; Pyruvic Acid; Zinc | 2000 |
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.
Topics: Acetylation; Adenosine Diphosphate Ribose; Animals; Chickens; Fungal Proteins; Gene Silencing; Histone Deacetylases; Histones; Lysine; Multigene Family; NAD; Niacinamide; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Trans-Activators | 2000 |
Direct NAD(P)H hydrolysis into ADP-ribose(P) and nicotinamide induced by reactive oxygen species: a new mechanism of oxygen radical toxicity.
Topics: Adenosine Diphosphate Ribose; Animals; Free Radicals; Hydrolysis; In Vitro Techniques; Male; Models, Biological; Myocardial Reperfusion Injury; NAD; NADP; Niacinamide; Rats; Rats, Wistar; Reactive Oxygen Species | 2000 |
On the irreversible destruction of reduced nicotinamide nucleotides by hypohalous acids.
Topics: Bromates; Chlorates; Hydrogen-Ion Concentration; Iodine Compounds; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; NAD; Niacinamide; Nicotinamide Mononucleotide; Oxidation-Reduction; Oxygen; Pyridines; Time Factors | 2000 |
Inhibition of the activity of poly (ADP-ribose) polymerase in ischemia-reperfusion injury.
Topics: Animals; DNA Damage; Drug Design; Energy Metabolism; Enzyme Inhibitors; Feedback; Humans; Ischemia; Myocardial Infarction; Myocardial Reperfusion Injury; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Reperfusion Injury; Solubility | 2000 |
Role of NAD(+) in the deacetylase activity of the SIR2-like proteins.
Topics: Adenosine Diphosphate Ribose; Amino Acid Sequence; Chromatography, High Pressure Liquid; Histone Deacetylases; Histones; Kinetics; Molecular Sequence Data; NAD; Niacinamide; Peptide Fragments; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Substrate Specificity; Trans-Activators | 2000 |
Role of the dinitrogenase reductase arginine 101 residue in dinitrogenase reductase ADP-ribosyltransferase binding, NAD binding, and cleavage.
Topics: ADP Ribose Transferases; Amino Acid Substitution; Arginine; Cross-Linking Reagents; Culture Media; Dinitrogenase Reductase; Immunoblotting; Mutagenesis, Site-Directed; NAD; Niacinamide; Photoaffinity Labels; Rhodospirillum rubrum; Ultraviolet Rays | 2001 |
Identification of a plasmid-encoded gene from Haemophilus ducreyi which confers NAD independence.
Topics: Amino Acid Sequence; Bacterial Proteins; Cloning, Molecular; Genes, Bacterial; Haemophilus ducreyi; Molecular Sequence Data; NAD; Niacinamide; Phosphoribosyl Pyrophosphate; Plasmids; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Species Specificity | 2001 |
Effects of nicotinamide coenzymes on the stability of enzyme activities and proteins in niacin-deficient quail tissues against trypsin treatment.
Topics: Animals; Coenzymes; Coturnix; Electrophoresis, Polyacrylamide Gel; Glyceraldehyde-3-Phosphate Dehydrogenases; Liver; Muscles; NAD; NADP; Niacin; Niacinamide; Oxidoreductases; Phosphogluconate Dehydrogenase; Time Factors; Trypsin | 2001 |
NAD+ inhibits the self-splicing of the group I intron.
Topics: Adenosine Diphosphate; Bacteriophage T4; Binding Sites; Dose-Response Relationship, Drug; Escherichia coli; Guanosine Triphosphate; Introns; Kinetics; Magnesium; Magnesium Chloride; Models, Chemical; NAD; NADP; Niacinamide; Plasmids; Recombinant Proteins; RNA; RNA Splicing; RNA, Messenger; Thymidylate Synthase; Transcription, Genetic | 2001 |
Lipid peroxidation in nicotinamide-deficient and nicotinamide-supplemented rats.
Topics: Animals; Antioxidants; Dietary Supplements; Glutathione; Lipid Peroxidation; Liver; Male; NAD; Niacinamide; Oxidation-Reduction; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Vitamin E | 2000 |
Rat ventral prostate xanthine oxidase bioactivation of ethanol to acetaldehyde and 1-hydroxyethyl free radicals: analysis of its potential role in heavy alcohol drinking tumor-promoting effects.
Topics: Acetaldehyde; Alcohol Drinking; Allopurinol; Animals; Antimetabolites; Caffeine; Carcinogens; Chromatography, Gas; Cytosol; Diet; Enzyme Inhibitors; Ethanol; Free Radicals; Gas Chromatography-Mass Spectrometry; Hypoxanthine; Male; Meat; NAD; Neoplasms; Niacinamide; Phosphodiesterase Inhibitors; Prostate; Prostatic Neoplasms; Purines; Rats; Rats, Sprague-Dawley; Spin Trapping; Temperature; Theobromine; Theophylline; Time Factors; Vasodilator Agents; Xanthine; Xanthine Oxidase | 2001 |
Cytochrome P450 4A, peroxisomal enzymes and nicotinamide cofactors in koala liver.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; DNA, Complementary; Female; Humans; Liver; Male; Marsupialia; Microsomes, Liver; Mixed Function Oxygenases; Molecular Sequence Data; NAD; Niacinamide; Palmitoyl Coenzyme A; Peroxisomes; Rats; Species Specificity | 2000 |
Dynamics of protein ligand binding on multiple time scales: NADH binding to lactate dehydrogenase.
Topics: Animals; Binding Sites; Kinetics; L-Lactate Dehydrogenase; Ligands; Models, Chemical; NAD; Niacinamide; Protein Binding; Proteins; Spectrometry, Fluorescence; Static Electricity; Swine; Temperature; Thermodynamics | 2001 |
Photochemical generation of cyclopentadienyliron dicarbonyl anion by a nicotinamide adenine dinucleotide dimer analogue.
Topics: Electrochemistry; Ferrous Compounds; Molecular Structure; NAD; Niacinamide; Oxidation-Reduction; Photochemistry; Spectrophotometry, Atomic; Structure-Activity Relationship | 2001 |
Oxidative changes in brain pyridine nucleotides and neuroprotection using nicotinamide.
Topics: Adenosine Triphosphate; Animals; Brain; DNA Fragmentation; Male; Mice; Mice, Inbred C57BL; NAD; NADP; Neuroprotective Agents; Niacinamide; Oxidation-Reduction; Oxidative Stress; Poly(ADP-ribose) Polymerases; Purine Nucleotides; tert-Butylhydroperoxide | 2001 |
Probing catalysis by Escherichia coli dTDP-glucose-4,6-dehydratase: identification and preliminary characterization of functional amino acid residues at the active site.
Topics: Amino Acid Substitution; Amino Acids; Binding Sites; Catalysis; Escherichia coli; Glucose; Hexosephosphates; Hydro-Lyases; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; NAD; Niacinamide; Pentosephosphates; Recombinant Proteins; Substrate Specificity; Thymine Nucleotides; Xylose | 2001 |
NadN and e (P4) are essential for utilization of NAD and nicotinamide mononucleotide but not nicotinamide riboside in Haemophilus influenzae.
Topics: Bacterial Outer Membrane Proteins; Bacterial Proteins; Biological Transport; Esterases; Haemophilus influenzae; Lipoproteins; Models, Biological; Multienzyme Complexes; NAD; Niacinamide; Nicotinamide Mononucleotide; Nucleotidases; Pyridinium Compounds; Pyrophosphatases | 2001 |
An old but simple and efficient method to elucidate the oxidation mechanism of NAD(P)H model 1-Aryl-1,4-dihydronicotinamides by cations 2-methyl-5-nitroisoquinolium, tropylium, and xanthylium in aqueous solution.
Topics: Cycloheptanes; Heterocyclic Compounds, 3-Ring; Kinetics; Models, Chemical; NAD; NADP; Niacinamide; Oxidation-Reduction; Quinolinium Compounds; Solutions; Structure-Activity Relationship; Thermodynamics | 2001 |
Allosteric activation of pyruvate kinase via NAD+ in rat liver cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Allosteric Regulation; Animals; Cell Separation; Dihydroxyacetone Phosphate; Energy Metabolism; Lactic Acid; Liver; Male; NAD; Niacinamide; Phosphoenolpyruvate; Pyruvate Kinase; Pyruvic Acid; Rats; Rats, Wistar | 2001 |
RNA aptamers that bind flavin and nicotinamide redox cofactors.
Topics: Base Sequence; Binding Sites; Evolution, Molecular; Guanosine; NAD; NADP; Niacinamide; Nicotinamide Mononucleotide; Oxidation-Reduction; Riboflavin; RNA; Sequence Analysis, RNA; Uridine | 1995 |
Negative control of p53 by Sir2alpha promotes cell survival under stress.
Topics: Animals; Apoptosis; Blotting, Western; Cell Death; Cell Line; Cell Survival; DNA Damage; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; fas Receptor; Histone Deacetylases; Humans; Mice; Mutagenesis, Site-Directed; NAD; Neoplasms; Niacinamide; Oxidative Stress; Point Mutation; Poly(ADP-ribose) Polymerases; Polymerase Chain Reaction; Protein Binding; Protein Structure, Tertiary; Sirtuin 1; Sirtuins; Trans-Activators; Transcriptional Activation; Tumor Suppressor Protein p53 | 2001 |
NAD degradation and regulation of CD38 expression by human monocytes/macrophages.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Cell Differentiation; Cells, Cultured; Cycloheximide; Down-Regulation; Humans; Macrophages; Membrane Glycoproteins; Monensin; Monocytes; NAD; NAD+ Nucleosidase; Niacinamide; Protein Synthesis Inhibitors | 2001 |
Metabolism of NAD+ in nuclei of Saccharomyces cerevisiae during stimulation of its biosynthesis by nicotinamide.
Topics: Adenosine Diphosphate Ribose; Cell Nucleus; NAD; Niacinamide; Poly(ADP-ribose) Polymerases; Pyrophosphatases; Saccharomyces cerevisiae | 2001 |
Bioorganometallic chemistry. 13. Regioselective reduction of NAD(+) models, 1-benzylnicotinamde triflate and beta-nicotinamide ribose-5'-methyl phosphate, with in situ generated [CpRh(Bpy)H](+): structure-activity relationships, kinetics, and mechanistic
Topics: Algorithms; Catalysis; Crystallography, X-Ray; Kinetics; Models, Molecular; Molecular Conformation; Molecular Structure; NAD; Niacinamide; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Ribose; Structure-Activity Relationship; Substrate Specificity; Time Factors | 2001 |
Pharmacological intakes of niacin increase bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats.
Topics: Alkylating Agents; Animals; Bone Marrow; Dietary Supplements; Dose-Response Relationship, Drug; Ethylnitrosourea; Leukopenia; Male; Morbidity; NAD; Neoplasms, Experimental; Niacin; Niacinamide; Poly Adenosine Diphosphate Ribose; Rats; Rats, Long-Evans; Time Factors | 2002 |
Rapid reversion of aging phenotypes by nicotinamide through possible modulation of histone acetylation.
Topics: Acetylation; Acetyltransferases; Antioxidants; beta-Galactosidase; Cell Division; Cell Line; Cell Size; Cellular Senescence; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Gene Expression; Histone Acetyltransferases; Histone Deacetylases; Histones; Humans; NAD; Niacin; Niacinamide; Oxidants; Phenotype; Poly(ADP-ribose) Polymerase Inhibitors; Saccharomyces cerevisiae Proteins | 2001 |
Reactivity of the B-H Bond in tris(pyrazolyl)hydroborato zinc complexes: unexpected example of zinc hydride formation in a protic solvent and its relevance towards hydrogen transfer to NAD(+) mimics by tris(pyrazolyl)hydroborato zinc complexes in alcoholi
Topics: Acridines; Alcohol Dehydrogenase; Alkanes; Boron Compounds; Catalysis; Cations; Deuterium; Electrochemistry; Hydroxides; Liver; Models, Molecular; Molecular Structure; NAD; Niacinamide; Organometallic Compounds; Zinc; Zinc Compounds | 2002 |
Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities.
Topics: Adenosine Triphosphate; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Amino Acid Sequence; Antigens, CD; Antigens, Differentiation; Binding Sites; Catalysis; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Dimerization; Disulfides; GPI-Linked Proteins; Humans; Ligands; Membrane Glycoproteins; Models, Chemical; Models, Molecular; Molecular Sequence Data; NAD; NAD+ Nucleosidase; NADP; Niacinamide; Nicotinamide Mononucleotide; Protein Binding; Protein Structure, Quaternary; Protein Structure, Tertiary; Sequence Alignment; Substrate Specificity | 2002 |
The chemistry of nicotinamide adenine dinucleotide (NAD) analogues containing C-nucleosides related to nicotinamide riboside.
Topics: Antineoplastic Agents; Cell Survival; Humans; IMP Dehydrogenase; NAD; Niacinamide; Organoselenium Compounds; Pyridinium Compounds; Ribavirin; Ribonucleosides; Ribonucleotides; Tumor Cells, Cultured | 2002 |
Bioavailability of reduced nicotinamide-adenine-dinucleotide (NADH) in the central nervous system of the anaesthetized rat measured by laser-induced fluorescence spectroscopy.
Topics: Administration, Oral; Anesthesia; Animals; Biological Availability; Cerebral Cortex; Fluorescence; Fluorometry; Lasers; Male; NAD; Niacinamide; Rats; Rats, Wistar; Spectrometry, Fluorescence | 2002 |
Productive trapping of NAD-type radicals. Non-biomimetic reduction of pyridinium salts.
Topics: Electrons; Free Radicals; Kinetics; Models, Chemical; NAD; Niacinamide; Oxidation-Reduction; Pyridinium Compounds | 2002 |
LC/MS analysis of NAD biosynthesis using stable isotope pyridine precursors.
Topics: Carbon Isotopes; Chromatography, Liquid; Isotopes; Macrophages; Mass Spectrometry; NAD; Niacinamide; Pyridines | 2002 |
The effects of nicotinamide on energy metabolism following transient focal cerebral ischemia in Wistar rats.
Topics: Adenosine Triphosphate; Animals; Brain; Cerebral Cortex; Corpus Striatum; Energy Metabolism; Ischemic Attack, Transient; Male; NAD; Neuroprotective Agents; Niacinamide; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Reperfusion; Time Factors | 2002 |
Amino acid residues in the nicotinamide binding site contribute to catalysis by horse liver alcohol dehydrogenase.
Topics: Alcohol Dehydrogenase; Amino Acid Substitution; Amino Acids; Animals; Binding Sites; Catalysis; Crystallography, X-Ray; Horses; Hydrogen; Kinetics; Liver; Mutagenesis, Site-Directed; NAD; Niacinamide; Protein Conformation; Structure-Activity Relationship; Valine | 2003 |
Molecular physiology: Tuned for longer life.
Topics: Caloric Restriction; Energy Metabolism; Heat-Shock Response; Histone Deacetylases; Longevity; NAD; Niacinamide; Nicotinamidase; Saccharomyces cerevisiae; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins | 2003 |
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.
Topics: Caloric Restriction; Cell Nucleus; Cytoplasm; Energy Metabolism; Gene Expression Regulation, Fungal; Gene Silencing; Heat-Shock Response; Histone Deacetylases; Longevity; NAD; Niacin; Niacinamide; Nicotinamidase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins | 2003 |
Longevity research. Single signal unites treatments that prolong life.
Topics: Caloric Restriction; Culture Media; DNA, Fungal; Genes, Fungal; Glucose; Histone Deacetylases; Humans; Longevity; NAD; Niacinamide; Nicotinamidase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins | 2003 |
Interactions between transhydrogenase and thio-nicotinamide Analogues of NAD(H) and NADP(H) underline the importance of nucleotide conformational changes in coupling to proton translocation.
Topics: Binding Sites; Crystallography, X-Ray; Dose-Response Relationship, Drug; Humans; Kinetics; Models, Biological; Models, Chemical; NAD; NADP; NADP Transhydrogenases; Niacinamide; Protein Binding; Protein Conformation; Temperature | 2003 |
Nicotinamide attenuates focal ischemic brain injury in rats: with special reference to changes in nicotinamide and NAD+ levels in ischemic core and penumbra.
Topics: Animals; Brain; Brain Ischemia; Chromatography, High Pressure Liquid; Male; NAD; Niacinamide; Rats; Rats, Inbred SHR; Regional Blood Flow | 2003 |
Hungering for simplicity.
Topics: Aging; Caloric Restriction; Histone Deacetylases; NAD; Niacinamide; Saccharomyces cerevisiae; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins | 2003 |
Formamides mimic aldehydes and inhibit liver alcohol dehydrogenases and ethanol metabolism.
Topics: Alcohol Dehydrogenase; Aldehydes; Animals; Central Nervous System Depressants; Crystallography, X-Ray; Ethanol; Formamides; Horses; Humans; Kinetics; Liver; Mice; Models, Chemical; Models, Molecular; NAD; Niacinamide; Protein Binding; Structure-Activity Relationship; Time Factors | 2003 |
Are poly(ADP-ribosyl)ation by PARP-1 and deacetylation by Sir2 linked?
Topics: Animals; Energy Metabolism; Humans; Models, Biological; NAD; Niacinamide; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Sirtuins | 2003 |
Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry.
Topics: Acetylation; Adenosine Diphosphate Ribose; Animals; Archaeoglobus fulgidus; Base Pairing; Gene Expression Regulation, Fungal; Histone Deacetylases; Lysine; Mice; Models, Biological; NAD; Niacinamide; Oxygen; Peptide Fragments; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 1; Sirtuin 2; Sirtuins; Species Specificity | 2003 |
Thermodynamics and kinetics of the hydride-transfer cycles for 1-aryl-1,4-dihydronicotinamide and its 1,2-dihydroisomer.
Topics: Electron Transport; Hydrogen; Kinetics; Models, Chemical; Molecular Structure; NAD; NADP; Niacinamide; Oxidation-Reduction; Protons; Pyridines; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship; Thermodynamics | 2003 |
Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression.
Topics: Carrier Proteins; Cell Line; Cell Nucleus; Chromatin; COUP Transcription Factors; DNA; DNA-Binding Proteins; Enzyme Inhibitors; Gene Silencing; Genes, Reporter; Glutathione Transferase; Histone Deacetylases; Humans; Hydroxamic Acids; Immunoblotting; Jurkat Cells; NAD; Neoplasm Proteins; Niacinamide; Nuclear Proteins; Precipitin Tests; Protein Binding; Receptors, Steroid; Recombinant Fusion Proteins; Repressor Proteins; Sirtuin 1; Sirtuins; Transcription Factors; Transcription, Genetic; Transfection; Tumor Suppressor Proteins | 2003 |
NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae.
Topics: Adenosine Diphosphate Ribose; Fungal Proteins; Gene Deletion; Gene Expression Regulation, Fungal; Genes, Fungal; Glutathione Transferase; Histone Deacetylases; Histones; NAD; Niacinamide; Nuclear Proteins; Promoter Regions, Genetic; Recombinant Proteins; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirtuins | 2003 |
Nicotinamide inhibition of tri-and diphosphopyridine nucleotide-linked dehydrogenases.
Topics: Coenzymes; NAD; Niacin; Niacinamide; Nicotinic Acids; Oxidoreductases | 1952 |
Separation and determination of vitamin B6 group (pyridoxine, pyridoxal, pyridoxamine, pyridoxal-phosphate and pyridoxamine-phosphate); separation by paper electrophoresis of riboflavin (riboflavin, FMN and FAD) and of nicotinamide (nicotinamide, DPN and
Topics: Coenzymes; Electrophoresis; Electrophoresis, Paper; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; NAD; Niacin; Niacinamide; Nicotinic Acids; Nucleotides; Phosphates; Pyridoxal; Pyridoxal Phosphate; Pyridoxamine; Pyridoxine; Riboflavin; Vitamin B 6 | 1954 |
[Paper chromatographic quantitative determination of nicotinic acid, nicotinamide, and codehydrogenase I and II in muscle tissue].
Topics: Chromatography, Paper; Coenzymes; Muscles; NAD; Niacin; Niacinamide; Nicotinic Acids | 1955 |
A streptococcal enzyme that acts specifically upon diphosphopyridine nucleotide: characterization of the enzyme and its separation from streptolysin O.
Topics: Bacterial Proteins; NAD; Niacinamide; Phosphoric Monoester Hydrolases; Pyridinium Compounds; Streptococcus; Streptolysins | 1957 |
Formation of the nicotinic acid analogue of diphosphopyridine nucleotide after nicotinamide administration.
Topics: Coenzymes; Liver; NAD; Niacin; Niacinamide; Nicotinic Acids; Organic Chemicals | 1959 |
Interaction of nicotinamide with reserpine and chlorpromazine. III. Some effects on the diphosphopyridine nucleotide content in liver.
Topics: Chlorpromazine; Coenzymes; Liver; NAD; Niacin; Niacinamide; Nicotinic Acids; Reserpine | 1960 |
[On the influence of carcinostatic agents on the DPN metabolism of tumors. I. Incorporation of C-14-ribose and C-14-nicotinamide into the DPN of ascites cells].
Topics: Antineoplastic Agents; Ascites; Coenzymes; NAD; Neoplasms; Niacin; Niacinamide; Nicotinic Acids; Ribose | 1960 |
[DPN and DPNH content of the liver of rats on a normal diet and fasting, treated with high doses of nicotinamide].
Topics: Animals; Biochemical Phenomena; Coenzymes; Fasting; Liver; NAD; Niacin; Niacinamide; Nicotinic Acids; Rats | 1960 |
Inhibiting effect of nicotinamide and diphosphopyridine nucleotide on the methylcholanthrene sarcoma in rats.
Topics: Animals; Coenzymes; Methylcholanthrene; NAD; Neoplasms; Niacin; Niacinamide; Nicotinic Acids; Rats; Sarcoma; Sarcoma, Experimental | 1961 |
The influence of nicotinamide and diphosphopyridine nucleotide on azo dye and methyl-cholanthrene carcinogenesis.
Topics: Animals; Azo Compounds; Benz(a)Anthracenes; Carcinogenesis; Coloring Agents; Methylcholanthrene; NAD; Neoplasms, Experimental; Niacin; Niacinamide; Nucleosides; Nucleotides; Organic Chemicals | 1960 |
Synthesis of diphosphopyridine nucleotide from nicotinamide by slices of liver.
Topics: Biochemical Phenomena; Coenzymes; Liver; NAD; Niacin; Niacinamide | 1959 |
Some observations on the preparation and properties of dihydronicotinamide-adenine dinucleotide.
Topics: Adenine; NAD; Niacinamide; Nucleosides; Nucleotides | 1962 |
Effect of hypophysectomy on liver diphosphopyridine nucleotide: the role of nicotinamide.
Topics: Coenzymes; Hypophysectomy; Liver; NAD; Niacin; Niacinamide; Nicotinic Acids | 1961 |
Effects of x-ray irradiation in ascites tumor cells: partial restoration of DPN content and DNA synthesis by nicotinamide.
Topics: Animals; Ascites; Coenzymes; DNA; DNA Replication; NAD; Neoplasms, Experimental; Niacin; Niacinamide; Nicotinic Acids; X-Rays | 1961 |
[Evaluation of nicotinic acid and nicotinamide for the biosynthesis of DPN in ascites tumor cells].
Topics: Ascites; Coenzymes; NAD; Neoplasms; Niacin; Niacinamide; Nicotinic Acids | 1961 |
Non-enzymic hydrogen exchange between nicotinamide adenine dinucleotides.
Topics: Hydrogen; NAD; Niacin; Niacinamide; Oxidation-Reduction | 1963 |
[Research on the relation between vitamin coenzymes and corresponding enzymes in relation to the age of the animal and under the influence of certain substances proper to the organism].
Topics: Acetylesterase; Adenine Nucleotides; Aging; Alanine Transaminase; Amino Acids; Animals; Aspartate Aminotransferases; Coenzymes; Cysteine; D-Alanine Transaminase; Folic Acid; Humans; NAD; Niacin; Niacinamide; Pantothenic Acid; Pyridoxine; Riboflavin; Thiamine; Thiamine Pyrophosphate; Vitamins | 1963 |
The inactivation of cortisol in experimental diabetic animals.
Topics: Anatomy; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Diabetes Mellitus; Diabetes Mellitus, Experimental; Hepatitis; Hepatitis A; Hydrocortisone; Insulin; NAD; Niacin; Niacinamide; Steroids; Testosterone | 1963 |
Studies on Ehrlich ascites cell nuclei. IV. Determination of nicotinamide adenosine dinucleotide pyrophosphorylase activity in nuclei isolated by an improved technique.
Topics: Adenosine; Animals; Ascites; Carcinoma; Carcinoma, Ehrlich Tumor; Cell Nucleus; NAD; Niacinamide; Phosphotransferases | 1963 |
Nicotinic acid and nicotinamide metabolism in ascites cells in vitro.
Topics: Animals; Ascites; Carcinoma; Carcinoma, Ehrlich Tumor; In Vitro Techniques; NAD; Niacin; Niacinamide; Nicotinic Acids | 1962 |
The incorporation of nicotinic acid and of nicotinamide into the pyridine nucleotides of erythrocytes and reticulocytes of rabbits in vitro.
Topics: Animals; Erythrocytes; In Vitro Techniques; NAD; NADP; Niacin; Niacinamide; Nicotinic Acids; Nucleotides; Rabbits; Reticulocytes | 1963 |
Diphosphopyridine nucleotide synthesis in brain following injection of various compounds.
Topics: Azaserine; Brain; NAD; Niacin; Niacinamide; Nicotinic Acids; Reserpine | 1963 |
Coenzyme analogs. I. Preparation and properties of thionicotinamide methiodide.
Topics: Coenzymes; NAD; Niacin; Niacinamide | 1963 |
Coenzyme analogs. II. Photochemical inactivation of reducd thionicotinamide adenine dinucleotide.
Topics: Coenzymes; Humans; NAD; Niacin; Niacinamide | 1963 |
A comparative study of the synthesis of nicotinamide nucleotides by erythrocytes of some vertebrates.
Topics: Animals; Erythrocytes; NAD; Niacinamide; Nucleotides; Vertebrates | 1963 |
The reaction of diphosphopyridine nucleotide and related pyridinium salts with alkali.
Topics: Alkalies; Coenzymes; Hydroxides; NAD; Niacinamide; Pyridines; Salts | 1963 |
A comparative study of nicotinamide nucleotide coenzymes during growth of the sheep and rat.
Topics: Animals; Coenzymes; Growth; Liver; NAD; NADP; Niacinamide; Nucleotides; Rats; Sheep; Sheep, Domestic | 1962 |
[DPN-DPNH, TPN-TPNH and pyridine compound content in the liver of the pregnant rat and fetus and in the placenta after large doses of nicotinamide].
Topics: Animals; Female; Fetus; Humans; Liver; Maternal-Fetal Exchange; NAD; NADP; Niacin; Niacinamide; Placenta; Pregnancy; Pregnancy, Animal; Rats | 1963 |
[The content of NAD, NADP and nicotinic acid amide in the brains of rats after the effects of centrally acting drugs].
Topics: Amides; Animals; Brain; Central Nervous System Agents; Hexachlorocyclohexane; NAD; NADP; Niacin; Niacinamide; Plants, Medicinal; Pyridines; Rats; Reserpine | 1963 |
Uptake of nicotinic acid-C-14 and nicotinamide-C-14 by ascites cells in vitro.
Topics: Ascites; In Vitro Techniques; NAD; Neoplasms; Neoplasms, Experimental; Niacin; Niacinamide; Nicotinic Acids | 1963 |
A FACTOR OTHER THAN STREPTOCOCCAL NICOTINAMIDE ADENINE DINUCLEOTIDASE WHICH COMBINES WITH ANTIBODY TO THIS ENZYME: ITS PRODUCTION AND EFFECT ON ANTIBODY DETERMINATIONS.
Topics: Adenine; Antibodies; Ascorbic Acid; Cysteine; Edetic Acid; Glutathione; Immunoglobulins; NAD; Niacinamide; Nucleotidases; Research; Streptococcus | 1963 |
[RECENT DATA ACQUIRED ON THE METABOLISM OF NUCLEIC ACIDS, THANKS TO THE USE OF RADIO-ISOTOPES. SPECIAL CONSIDERATIONS OF THE TIES BETWEEN NUCLEIC ACID METABOLISM AND PROTEIN METABOLISM].
Topics: Adenosine Triphosphate; Animals; Brain; Carbon Isotopes; Cell Nucleus; Centrifugation; Chromatography; DNA; Estradiol; Hepatectomy; Kidney; Leucine; Liver; NAD; Niacin; Niacinamide; Nucleotidases; Nucleotides; Phosphates; Phosphorus Isotopes; Poultry; Protein Deficiency; Proteins; Rats; Research; RNA; Tyrosine | 1963 |
[ON THE EFFECT OF HYDROGEN PEROXIDE-FORMING QUINONES ON TUMOR CELLS].
Topics: Adenosine Triphosphate; Animals; Carbohydrate Metabolism; Carcinoma; Carcinoma, Ehrlich Tumor; Catalase; Esterases; Hydrogen Peroxide; NAD; Niacin; Niacinamide; Phenols; Quinones | 1963 |
SUBSTITUTED NICOTINAMIDE ANALOGUES OF NICOTINAMIDE ADENINE DINUCLEOTIDE.
Topics: Chemical Phenomena; Chemistry; NAD; Niacin; Niacinamide; Organic Chemicals; Research | 1963 |
RADIATION INJURY TO MEMBRANE PERMEABILITY OF ELECTROLYTES.
Topics: Adenosine Triphosphate; Cell Membrane Permeability; Cesium Isotopes; Electrolytes; Erythrocytes; Glucose; NAD; Niacinamide; Nucleosides; Nucleotides; Permeability; Potassium; Radiation Injuries; Radiation Injuries, Experimental; Rats; Research; Sodium | 1963 |
EFFECTS OF BACTERIAL ENDOTOXINS ON METABOLISM. VI. THE ROLE OF TRYPTOPHAN PYRROLASE IN RESPONSE OF MICE TO ENDOTOXIN.
Topics: Adrenalectomy; Animals; Cortisone; Endotoxins; Liver; Mice; NAD; Niacin; Niacinamide; Nicotinic Acids; Nucleotides; Peroxidases; Polysaccharides; Polysaccharides, Bacterial; Proteins; Research; Salmonella typhimurium; Serratia marcescens; Tryptophan; Tryptophan Oxygenase | 1963 |
SYNTHESIS OF NICOTINAMIDE ADENINEDINUCLEOTIDE ANALOGS AND THEIR COENZYMATIC ACTIVITIES.
Topics: Alcohol Oxidoreductases; Coenzymes; L-Lactate Dehydrogenase; Liver; Myocardium; NAD; Niacinamide; Oxidoreductases; Research; Yeasts | 1963 |
INHIBITION OF TUMOR CELL GLYCOLYSIS BY DPNH2, AND REVERSAL OF THE INHIBITION BY DPN, PYRUVATE OR METHYLENE BLUE.
Topics: Animals; Carbohydrate Metabolism; Carcinoma, Ehrlich Tumor; Carcinoma, Krebs 2; Glycolysis; Melanoma; Methylene Blue; Mice; NAD; NADP; Neoplasms, Experimental; Niacin; Niacinamide; Pharmacology; Pyruvates; Pyruvic Acid; Research | 1963 |
[DPN SYNTHESIS WITH NICOTINIC ACID AMIDE IN CELL FREE EXTRACTS OF EHRLICH ASCITES TUMOR CELLS].
Topics: Amides; Animals; Antineoplastic Agents; Aziridines; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Imines; Mice; NAD; Niacin; Niacinamide; Pharmacology; Proteins; Research | 1963 |
SYNTHESIS OF GLUTAMATE FROM ALPHA-OXOGLUTARATE AND AMMONIA IN RAT-LIVER MITOCHONDRIA. IV. REDUCTION OF NICOTINAMIDE NUCLEOTIDE COUPLED WITH THE AEROBIC OXIDATION OF TETRAMETHYL-RHO-PHENYLENEDIAMINE.
Topics: Ammonia; Amobarbital; Aniline Compounds; Anti-Bacterial Agents; Dinitrophenols; Enzyme Inhibitors; Glutamates; Glutamic Acid; Ketoglutaric Acids; Liver; Malates; Metabolism; Mitochondria; Mitochondria, Liver; Myocardium; NAD; Niacinamide; Nucleotides; Oligomycins; Oxidation-Reduction; Pharmacology; Phenylenediamines; Rabbits; Rats; Research; Succinates | 1963 |
[DAMAGE TO THE CENTRAL NERVOUS SYSTEM BY ANTIMETABOLITES OF NICOTINAMIDE. A CONTRIBUTION TO MOLECULAR PATHOLOGY OF PYRIDINE NUCLEOTIDES].
Topics: Antimetabolites; Central Nervous System; NAD; NADP; Niacin; Niacinamide; Nucleotides; Pathology, Molecular; Pyridines; Rats; Research; Toxicology | 1963 |
NICOTINAMIDE NUCLEOTIDE COENZYMES AND GLUCOSE METABOLISM IN THE LIVERS OF FOETAL AND NEWBORN LAMBS.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Body Weight; Carbohydrate Metabolism; Coenzymes; DNA; Female; Fetus; Glucose; Glucosephosphate Dehydrogenase; Liver; Metabolism; NAD; NADP; Niacinamide; Phosphorus; Pregnancy; Pregnancy, Animal; Rats; Research; Sheep; Sheep, Domestic | 1963 |
OXIDATIVE PHOSPHORYLATION FROM EXOGENOUS PYRIDINE NUCLEOTIDES.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Cattle; Dialysis; Liver; Metabolism; Mitochondria; Myocardium; NAD; NADP; Niacin; Niacinamide; Nucleotides; Oxidative Phosphorylation; Pyridines; Renal Dialysis; Research | 1963 |
BIOCHEMISTRY OF THE DEVELOPING RAT BRAIN. IV. EFFECT OF NICOTINAMIDE ON BRAIN AND LIVER MITOCHONDRIA.
Topics: Brain; Citrates; Cytochromes; Isocitrate Dehydrogenase; Liver; Metabolism; Mitochondria; Mitochondria, Liver; NAD; NADP; Niacinamide; Oxidoreductases; Pharmacology; Rats; Research | 1963 |
STUDIES ON MORPHINE. IV. EFFECTS OF SOME METABOLITES ON THE "ABSTINENCE SYNDROME" TO MORPHINE ON WHITE MICE.
Topics: Alanine; Cyanides; Fluoroacetates; Glutamine; Iodoacetates; Mice; Morphine; NAD; Nalorphine; Niacin; Niacinamide; Pharmacology; Pyridines; Pyridoxine; Research; Serine; Toxicology; Tryptophan | 1963 |
[METABOLISM OF GLUCOSE AND FRUCTOSE IN THE HUMAN PLACENTA].
Topics: Adenine Nucleotides; Adenosine Triphosphate; Carbohydrate Metabolism; Female; Fructose; Glucose; NAD; NADP; Niacin; Niacinamide; Pharmacology; Placenta; Pregnancy | 1963 |
EFFECTS OF NICOTINAMIDE, ISONICOTINIC ACID HYDRAZIDE, AND 3-ACETYLPYRIDINE ON THE GROWTH AND NICOTINAMIDE ADENINE DINUCLEOTIDE CONTENT OF L CELLS.
Topics: Alcohol Oxidoreductases; Cell Division; Isoniazid; NAD; NADP; Niacin; Niacinamide; Pharmacology; Pyridines; Research; Research Design; Tissue Culture Techniques | 1963 |
[SOME ASPECTS OF THE REGULATION OF RIBONUCLEIC ACID BIOSYNTHESES IN HIGHER ANIMALS].
Topics: Carcinoma, Hepatocellular; Chromatography; Leucine; Liver; Liver Neoplasms; Metabolism; NAD; Neoplasms, Experimental; Niacinamide; Nucleoproteins; Nucleotidases; Phosphorus Isotopes; Proteins; Rats; Research; RNA; RNA, Messenger; Vitamin E Deficiency | 1964 |
TISSUE METABOLISM IN INFECTION. SOLUBLE NICOTINAMIDE-ADENINE DINUCLEOTIDASE IN ORGANS FROM TUBERCULOUS MICE.
Topics: Adenine; Animals; Liver; Lung; Metabolism; Mice; Mycobacterium tuberculosis; NAD; Niacin; Niacinamide; Nucleotidases; Research; Tuberculosis | 1964 |
STUDIES ON THE NOENZYMIC HYDROGEN EXCHANGE BETWEEN NICOTINAMIDE ADENINE DINUCLEOTIDES.
Topics: Alcohol Oxidoreductases; Chromatography; Hydrogen; NAD; NADP; Niacin; Niacinamide; Oxidation-Reduction; Research; Spectrophotometry; Tritium | 1964 |
PURINE METABOLISM IN THE CHICK EMBRYO: INFLUENCE OF 2-SUBSTITUTED THIADIAZOLES.
Topics: Abnormalities, Drug-Induced; Allantoin; Animals; Carbon Isotopes; Chick Embryo; Chromatography; Formates; Hypoxanthines; Insulin; Metabolism; Methionine; Methionine Sulfoximine; NAD; Niacin; Niacinamide; Nucleosides; Purines; Pyridines; Research; Serine; Sulfanilamide; Sulfanilamides; Thiadiazoles; Thiazoles; Toxicology; Triazines; Uric Acid; Uricosuric Agents | 1964 |
TISSUE METABOLISM IN INFECTION: BIOCHEMICAL CHANGES IN MICE TREATED WITH CORD FACTOR.
Topics: Animals; Antitoxins; Cord Factors; Hydroxybutyrates; Lactates; Lipids; Liver; Lung; Manometry; Metabolism; Mice; Mycobacterium Infections; Mycobacterium tuberculosis; NAD; Niacinamide; Nucleotidases; Research; Spleen; Succinates; Toxicology; Toxins, Biological | 1964 |
NICOTINAMIDE ADENINE DINUCLEOTIDE LEVELS IN RAT BRAIN.
Topics: Brain; Dietary Fats; Metabolism; NAD; NADP; Niacin; Niacinamide; Nicotinic Acids; Pharmacology; Protein Deficiency; Rats; Research; Reserpine; Tryptophan | 1964 |
OXIDATION OF REDUCED NICOTINAMIDE NUCLEOTIDES IN THE CENTRAL NERVOUS SYSTEM OF SOME MARINE INVERTEBRATES.
Topics: Brain; Central Nervous System; Cytochromes; Ferrocyanides; Glutathione; Invertebrates; Mollusca; NAD; NADP; Niacinamide; Nucleotides; Oxidation-Reduction; Oxidoreductases; Pharmacology; Research; Spectrophotometry; Vitamin K | 1964 |
STERO-BILE ACIDS AND BILE STEROLS. LXI. METABOLISM OF LITHOCHOLIC ACID IN HOG LIVER PREPARATION.
Topics: Adenosine Triphosphate; Animals; Bile; Bile Acids and Salts; Brain; Calcium; Carbon Isotopes; Fluorides; Glutathione; Heart; Kidney; Lithocholic Acid; Liver; Magnesium; Malonates; Metabolism; Microsomes; Mixed Function Oxygenases; NAD; Niacinamide; Pharmacology; Research; Salts; Sterols; Swine | 1964 |
SEROTONIN-MEDIATED OXIDATION OF DIHYDRONICOTINAMIDE DERIVATIVES BY CYTOCHROME C.
Topics: Cytochromes; Cytochromes c; Electron Transport; Manganese; NAD; Niacinamide; Oxidation-Reduction; Research; Serotonin; Spectrophotometry | 1964 |
NICOTINAMIDE ADENINE DINUCLEOTIDASE ACTIVITY IN CELLS OF TUBERCULOUS ANIMALS.
Topics: Adenine; Animals; Guinea Pigs; Leukocytes; Lymphoid Tissue; Metabolism; Mice; Monocytes; NAD; Niacinamide; Nucleotidases; Research; Tuberculosis | 1964 |
FETAL DEATH FROM NICOTINAMIDE-DEFICIENT DIET AND ITS PREVENTION BY CHLORPROMAZINE AND IMIPRAMINE.
Topics: Animals; Avitaminosis; Chlorpromazine; Diet; Female; Fetal Death; Fetus; Imipramine; Liver; NAD; Niacin; Niacinamide; Nicotinic Acids; Pharmacology; Pregnancy; Pregnancy, Animal; Rats; Research; Tryptophan | 1964 |
METABOLISM OF REDUCED PYRIDINE NUCLEOTIDES IN ASCITES CELL NUCLEI.
Topics: Amobarbital; Ascites; Cell Nucleus; Citrates; Fluorescence; Fluorometry; Glucose; Histocytochemistry; Metabolism; Microscopy; Microscopy, Interference; NAD; NADP; Niacin; Niacinamide; Nucleotides; Pharmacology; Research; Succinates; Tissue Culture Techniques | 1964 |
THE EFFECT OF SHORT-TERM FEEDING EXPERIMENTS WITH 3'-METHYL-4-DIMETHYLAMINOAZOBENZENE OF RAT-LIVER MITOCHONDRIAL FUNCTION.
Topics: Carcinoma, Hepatocellular; Citrates; Citric Acid Cycle; Glutamates; Hydroxybutyrates; Isocitrate Dehydrogenase; Ketoglutaric Acids; Liver; Liver Neoplasms; Malate Dehydrogenase; Metabolism; Methyldimethylaminoazobenzene; Microsomes; Mitochondria; N-Glycosyl Hydrolases; NAD; NADP; Niacinamide; Ornithine; Ornithine Carbamoyltransferase; Oxidoreductases; p-Dimethylaminoazobenzene; Rats; Research; Succinate Dehydrogenase; Toxicology | 1964 |
NICOTINAMIDE ADENINE DINUCLEOTIDE SYNTHESIS IN ASCITES CELLS IN VITRO.
Topics: Ascites; Carbon Isotopes; Chromatography; Glucose; Glutamine; In Vitro Techniques; Metabolism; Mice; NAD; Niacin; Niacinamide; Nicotinic Acids; Phosphates; Phosphorus Isotopes; Research; Tissue Culture Techniques | 1964 |
THE RELATIONSHIP BETWEEN 3 ALPHA-HYDROXYSTEROID NICOTINAMIDE NUCLEOTIDE COENZYME TRANSHYDROGENATION AND BETA-GLUCURONIDASE IN REGENERATING RAT LIVER.
Topics: Androsterone; Coenzymes; Dialysis; Glucuronates; Glucuronidase; Heparin; Hepatectomy; Hydroxysteroids; Lactones; Liver; Liver Extracts; Liver Regeneration; Mercaptopurine; Methotrexate; NAD; NADP; Niacin; Niacinamide; Nucleotides; Oxidoreductases; Perfusion; Pharmacology; Rats; Renal Dialysis; Research; Spectrophotometry | 1964 |
THE ROLE OF THE GRANULOSA CELL IN THE BIOSYNTHESIS OF OVARIAN STEROID HORMONES.
Topics: Adenosine Triphosphate; Androgens; Animals; Chromatography; Estradiol; Estrone; Female; Fumarates; Granulosa Cells; Hormones; Humans; Hydroxyprogesterones; Isomerases; Metabolism; NAD; NADP; Niacinamide; Ovary; Oxidoreductases; Pharmacology; Pregnenolone; Progesterone; Research; Swine; Testosterone | 1964 |
NICOTINIC ACID ANALOGS: EFFECTS ON RESPONSE OF CHICK EMBRYOS AND HENS TO ORGANOPHOSPHATE TOXICANTS.
Topics: Abnormalities, Drug-Induced; Animals; Biological Assay; Carbamates; Central Nervous System; Chick Embryo; Chickens; Cholinesterases; Cresols; Female; Glossitis; Growth; Histocytochemistry; Insecticides; NAD; Nervous System; Niacin; Niacinamide; Organophosphorus Compounds; Pharmacology; Phosphates; Poultry; Research; Toxicology; Tritolyl Phosphates | 1964 |
THE EFFECT OF SPORIDESMIN ON LIVER ENZYME SYSTEMS.
Topics: Alcohols; Antitoxins; Citrates; Edetic Acid; Enzyme Inhibitors; Ethanol; Glutamates; Glutathione; Liver; Malates; Mitochondria; NAD; Niacin; Niacinamide; Oxidoreductases; Pathology; Pharmacology; Rats; Research; Sporidesmins; Succinates; Toxicology; Toxins, Biological | 1964 |
PITUITARY INFLUENCE OF PYRIDINE NUCLEOTIDE METABOLISM OF RAT LIVER.
Topics: Adrenal Glands; Brain Chemistry; Fluorometry; Hypophysectomy; Intestines; Kidney; Liver; Lung; Metabolism; Muscles; Myocardium; NAD; NADP; Niacin; Niacinamide; Pharmacology; Pituitary Gland; Rats; Research; Spectrophotometry; Spleen; Tryptophan | 1964 |
COMPARISON OF THE ACTIONS OF HUMAN BRAIN, LIVER, AND HEART LACTIC DEHYDROGENASE VARIANTS ON NUCLEOTIDE ANALOGUES AND ON SUBSTRATE ANALOGUES IN THE ABSENCE AND IN THE PRESENCE OF OXALATE AND OXAMATE.
Topics: Brain; Butyrates; Heart; Keto Acids; L-Lactate Dehydrogenase; Lactates; Liver; Metabolism; Myocardium; NAD; Niacinamide; Nucleotides; Oxalates; Oxidoreductases; Pyruvates; Research; Species Specificity | 1964 |
[THE PROTECTIVE EFFECT OF NICOTINAMIDE ON RADIATION-INDUCED INJURY OF DNA SYNTHESIS AS A CELL POPULATION PROBLEM].
Topics: Animals; Carbohydrate Metabolism; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; NAD; Neoplasm Proteins; Neoplasms; Neoplasms, Experimental; Niacin; Niacinamide; Pharmacology; Proteins; Radiation Effects | 1964 |
[INHIBITION OF PHOSPHOKINASES BY THE 6-AMINONICOTINAMIDE ANALOG (6 ANAD) OF NICOTINE-ADENINE-DINUCLEOTIDE (NAD)].
Topics: 6-Aminonicotinamide; Adenine; Animals; Creatine Kinase; Enzyme Inhibitors; Glucosephosphate Dehydrogenase; Hexokinase; Muscles; NAD; Niacin; Niacinamide; Nicotine; Oxidative Phosphorylation; Pharmacology; Phosphotransferases; Pyruvate Kinase; Rabbits; Research | 1964 |
[CLINICAL OBSERVATIONS AND THERAPEUTIC RESULTS IN SUBJECTS WITH ISCHEMIC CARDIOPATHY TREATED WITH AN ENZYME COMPLEX ASSOCIATED WITH A VASODILATOR DRUG].
Topics: Adenosine Triphosphate; Coronary Disease; Drug Therapy; Electrocardiography; Flavin Mononucleotide; Myocardial Ischemia; NAD; Niacin; Niacinamide; Theophylline; Thiamine Pyrophosphate; Vasodilator Agents | 1964 |
[SPECTROFLUOROMETRIC DETERMINATION OF THEINCORPORATION OF 6-AMINONICOTINAMIDE INTO OXIDATED PYRIDINE NUCLEOTIDE IN THE KIDNEY].
Topics: 6-Aminonicotinamide; Fluorometry; Kidney; NAD; NADP; Niacin; Niacinamide; Nucleotides; Rats; Research; Spectrum Analysis | 1964 |
[THE EXCHANGE BETWEEN 3-ACETYLPYRIDINE AND NICOTINAMIDE IN THE PYRIDINE NUCLEOTIDES IN DIFFERENT REGIONS OF THE BRAIN].
Topics: Brain; Brain Chemistry; Fluorometry; Metabolism; NAD; NADP; Niacin; Niacinamide; Nucleotides; Pyridines; Rats; Research; Spectrum Analysis | 1964 |
EFFECT OF ENDOTOXIN ON LIVER CARBOHYDRATE OF MICE BEARING TRANSPLANTABLE TUMORS SARCOMA 37 AND KREBS-2 CARCINOMA.
Topics: Animals; Carcinoma; Carcinoma, Krebs 2; Cortisone; Endotoxins; Iron-Dextran Complex; Liver; Liver Glycogen; Mice; NAD; Neoplasm Transplantation; Niacin; Niacinamide; Oxygenases; Pharmacology; Research; Sarcoma 37; Sarcoma, Experimental | 1964 |
[PROPERTIES OF DINUCLEOTIDE PYROPHOSPHATASE FROM RAT KIDNEY PARTICLES AND COENZYME PRODUCTS OF THE END PRODUCTS DIHYDRONICOTINAMIDE MONONUCLEOTIDE AND DIHYDRONICOTINAMIDE RIBOSIDE].
Topics: Adenine Nucleotides; Coenzymes; Kidney; NAD; Niacinamide; Nucleosides; Nucleotides; Pyrophosphatases; Rats; Research | 1964 |
THE ROLE OF DPNASE IN THE MECHANISM OF ACTION OF AN ANTITUMOR ALKYLATING AGENT ON EHRLICH ASCITES CELLS.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Ascites; Carbohydrate Metabolism; Carcinoma; Carcinoma, Ehrlich Tumor; NAD; NAD+ Nucleosidase; Niacinamide; Nucleotidases; Pharmacology; Pyridines; Research; Tissue Culture Techniques | 1964 |
COMPARTMENTATION OF NICOTINAMIDE DINUCLEOTIDE DEHYDROGENASES AND TRANSHYDROGENASES IN NONPHOTOSYNTHETIC PLANT TISSUES.
Topics: Kinetics; Microsomes; Mitochondria; NAD; NADP; Niacinamide; Oxidoreductases; Plants; Research | 1964 |
[RESEARCH ON THE MECHANISM OF THE SEDATIVE ACTION OF NICOTINAMIDE].
Topics: Animals; Electroshock; Hypnotics and Sedatives; Liver; Metabolism; Mice; NAD; Niacin; Niacinamide; Pentylenetetrazole; Pharmacology; Research; Reserpine; Shock; Strychnine | 1963 |
PYRUVATE AND LACTATE LEVELS IN RELATIONSHIP TO THE NICOTINAMIDE--ADENINE DINUCLEOTIDE LEVELS IN MALARIAL PARASITES (PLASMODIUM BERGHEI).
Topics: Adenine; Animals; Erythrocytes; Glucose; L-Lactate Dehydrogenase; Lactates; Lactic Acid; N-Glycosyl Hydrolases; NAD; Niacinamide; Parasites; Phenylhydrazines; Plasmodium; Plasmodium berghei; Pyruvates; Pyruvic Acid; Rats; Research; Reticulocytes | 1964 |
[DEMONSTRATION AND PROPERTIES OF NICOTINAMIDE-N1-BETA-D-GLUCO-PYRANOSYLPHOSPATE AND NICOTINAMIDE-GLUCOSIDE-ADENINE-DINUCLEOTIDE].
Topics: Adenine; Chemical Phenomena; Chemistry; Glucosides; NAD; Niacin; Niacinamide; Nucleotides; Research | 1964 |
[PHOTOCHEMISTRY OF REDUCED PYRIDINE NUCLEOTIDES AND N-BENZYLNICOTINAMIDE].
Topics: Chemical Phenomena; Chemistry, Physical; Light; NAD; Niacin; Niacinamide; Nucleotides; Photochemistry; Research | 1964 |
[SYNTHESIS AND PROPERTIES OF NICOTINAMIDE-ADENINE-NL-OXIDE-DINUCLEOTIDE].
Topics: Adenine; Chemistry Techniques, Analytical; Chromatography; NAD; Niacinamide; Nucleotides; Organic Chemicals; Oxides; Radiation Effects; Research | 1964 |
HEPATIC NUCLEOTIDE LEVELS AND NAD-SYNTHESIS AS INFLUENCED BY DIETARY OROTIC ACID AND ADENINE.
Topics: Adenine; Adenine Nucleotides; Diet; Guanine Nucleotides; Lipids; Liver; Metabolism; NAD; Niacin; Niacinamide; Nicotinic Acids; Nucleotides; Orotic Acid; Rats; Research; Spectrum Analysis; Uracil Nucleotides | 1965 |
NAD+-GLYCOHYDROLASE OF THYROID HOMOGENATES.
Topics: Animals; Biochemical Phenomena; Biochemistry; Diiodotyrosine; Isoniazid; Metabolism; N-Glycosyl Hydrolases; NAD; NAD+ Nucleosidase; NADP; Niacin; Niacinamide; Rats; Research; Spectrophotometry; Swine; Thyroid Gland | 1964 |
EFFECT OF CARCINOPHILIN ON DPN-SYNTHESIS AND GLYCOLYSIS OF TUMOR CELLS.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antineoplastic Agents; Carbohydrate Metabolism; Glycerophosphates; Glycolysis; Lactates; Metabolism; NAD; Niacin; Niacinamide; Nucleotidases; Nucleotides; Pharmacology; Phosphates; Pyruvates; Research; Sarcoma; Sarcoma, Yoshida | 1964 |
ENZYMATIC CONVERSION OF SEROTONIN TO 5-HYDROXYTRYPTOPHOL.
Topics: Carbon Isotopes; Hydroxytryptophol; Indoles; Liver; Metabolism; NAD; Niacinamide; Radiometry; Research; Serotonin | 1965 |
[STUDIES ON LEUKOCYTE METABOLISM. NICOTINAMIDE-ADENINE-DINUCLEOTIDE (NAD) CONTENT OF NORMAL AND LEUKEMIC LEUKOCYTES IN MAN. II].
Topics: Adenine; Blood Cell Count; Blood Chemical Analysis; Erythrocytes; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Lymphocytes; NAD; Niacinamide | 1965 |
THE STEREOSPECIFICITY OF THE HILL REACTION WITH DIPHOSPHOPYRIDINE NUCLEOTIDE.
Topics: Alcohol Oxidoreductases; Chemical Phenomena; Chemistry; Chlorophyll; Chloroplasts; Ferredoxins; Flavins; Glutamate Dehydrogenase; Iron; NAD; NADP; Niacin; Niacinamide; Organoids; Oxidoreductases; Research; Tritium | 1965 |
ENDOCRINE INVOLVEMENT IN THE SUPPRESSION OF NAD SYNTHESIS PRODUCED BY HYPERPHYSIOLOGICAL LEVELS OF STEROID HORMONES.
Topics: Adrenal Glands; Adrenalectomy; Amidohydrolases; Hexestrol; Hormones; Hydrocortisone; Hypophysectomy; Liver; Metabolism; NAD; Niacin; Niacinamide; Pharmacology; Physiology; Pituitary Gland; Rats; Research; Thyroid Gland; Thyroidectomy | 1965 |
[EFFECT OF NICOTINAMIDE ON THE CONTENT OF NAD IN THE RAT TISSUE AT REST AND DURING MUSCULAR ACTIVITY].
Topics: NAD; Niacin; Niacinamide; Physical Exertion; Research | 1965 |
[INVESTIGATION ON THE DECREASE IN CONCENTRATION OF NAD IN LYMPHOSARCOMA ASCITES CELLS FOLLOWING X-IRRADIATION].
Topics: Ascites; Chromatography; Lymphoma; Lymphoma, Non-Hodgkin; Metabolism; NAD; Neoplasms; Neoplasms, Experimental; Niacin; Niacinamide; Phosphorus Isotopes; Radiation Effects; Research; Ribose | 1965 |
PHOSPHOLIPID--PROTEIN INTERACTION AS A DETERMINANT FOR THE SUBSTRATE SPECIFICITY OF MITOCHONDRIAL NICOTINAMIDE--ADENINE-DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASE.
Topics: Adenine; Biochemical Phenomena; Biochemistry; Catalysis; Lysophosphatidylcholines; Mitochondria; Myocardium; NAD; NADP; NADP Transhydrogenases; Niacinamide; Oxidoreductases; Phosphates; Phospholipases; Phospholipids; Rats; Research; Substrate Specificity | 1965 |
THE EFFECTS OF X-RADIATION ON LACTATE METABOLISM OF MAMMALIAN CELLS.
Topics: Amines; Carbohydrate Metabolism; Carbon Dioxide; L Cells; Lactates; Lactic Acid; NAD; Niacinamide; Pharmacology; Phosphates; Radiation Effects; Rats; Research; Sodium Chloride; Thymus Gland; Tissue Culture Techniques; X-Rays | 1965 |
[COMPARATIVE STUDIES ON THE BIOSYNTHESIS OF NAD(P)-ANALOGS OF 3-ACETYLPYRIDINE, 4-ACETYLPYRIDINE, 6-AMINONICOTINAMIDE AND ISONICOTINIC ACID HYDRAZIDE].
Topics: 6-Aminonicotinamide; Brain; Isoniazid; NAD; Niacin; Niacinamide; Pyridines; Rats; Research | 1964 |
STEREOSPECIFICITY OF THE ENZYMIC NAD SYNTHESIS.
Topics: Chromatography; Erythrocytes; Liver; Metabolism; NAD; Niacin; Niacinamide; Nicotinic Acids; Rats | 1965 |
HYDROPHOBIC INTERACTIONS OF INHIBITORS WITH YEAST ALCOHOL DEHYDROGENASE.
Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Chemical Phenomena; Chemistry; Chlorides; Enzyme Inhibitors; Hydrophobic and Hydrophilic Interactions; NAD; Niacin; Niacinamide; Oxidation-Reduction; Research | 1965 |
EFFECT OF HYPERPHYSIOLOGICAL LEVELS OF STEROID HORMONES ON NICOTINAMIDE DEAMIDASE AND NAD SYNTHESIS IN MOUSE LIVER TISSUE.
Topics: Adrenal Cortex Hormones; Amidohydrolases; Animals; Cortisone; Diethylstilbestrol; Estradiol; Estriol; Estrone; Hexestrol; Hydrocortisone; Liver; Mice; NAD; Niacin; Niacinamide; Nicotinamidase; Pharmacology; Research; Steroids | 1965 |
KINETICS OF NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENATION BY HUMAN PLACENTA.
Topics: Biochemical Phenomena; Biochemistry; Catalysis; Estradiol; Estrone; Female; Humans; Kinetics; NAD; NADP; Niacinamide; Oxidation-Reduction; Oxidoreductases; Placenta; Pregnancy; Research; Spectrophotometry | 1965 |
THE ESTIMATION OF THE OXIDIZED AND REDUCED FORMS OF THE NICOTINAMIDE NUCLEOTIDES.
Topics: Adipose Tissue; Alcohol Oxidoreductases; Animals; Carcinoma, Hepatocellular; Glucosephosphate Dehydrogenase; Liver; Liver Neoplasms; Mammary Glands, Animal; NAD; NADP; Niacinamide; Nucleotides; Oxidation-Reduction; Pharmacology; Phenazines; Plants, Edible; Polarography; Rats; Research | 1965 |
THE EFFECT OF DIFFERENT HORMONAL CONDITIONS ON THE CONCENTRATION AND OXIDOREDUCTION STATE OF THE NICOTINAMIDE NUCLEOTIDES OF RAT LIVER.
Topics: Adrenalectomy; Animals; Carbohydrate Metabolism; Cortisone; Diabetes Mellitus, Experimental; Glucagon; Glucose; Glucosephosphate Dehydrogenase; Growth Hormone; Lipid Metabolism; Liver; NAD; NADP; Niacinamide; Nucleotides; Oxidation-Reduction; Oxidoreductases; Pharmacology; Phosphogluconate Dehydrogenase; Rats; Research; Toxicology | 1965 |
CONTENT AND SYNTHESIS OF HEPATIC PYRIDINE NUCLEOTIDES IN FETAL AND NEONATAL RABBITS.
Topics: Aging; Animals; DNA; Female; Fetus; Humans; Liver; Maternal-Fetal Exchange; Metabolism; NAD; NADP; Niacinamide; Nitrogen; Placenta; Plasma; Pregnancy; Pregnancy, Animal; Rabbits; Research; Umbilical Cord; Uterus; Water | 1965 |
STIMULATION OF DPN TURNOVER IN ASCITES TUMOR CELLS BY LOW X-RAY DOSES.
Topics: Animals; Ascites; Carcinoma; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Metabolism; N-Glycosyl Hydrolases; NAD; Neoplasms; Niacinamide; Radiation Effects; Research; X-Rays | 1965 |
THE FATE OF NICOTINAMIDE IN THE MOUSE; TISSUE METABOLITES.
Topics: Alcohol Oxidoreductases; Animals; Chromatography; Intestines; Kidney; Liver; Lung; Metabolism; Mice; Muscles; Myocardium; NAD; Niacin; Niacinamide; Phenazines; Research | 1965 |
NICOTINAMIDE-ADENINE DINUCLEOTIDE-GLYCOHYDROLASE ACTIVITY IN EXPERIMENTAL TUBERCULOSIS.
Topics: Animals; Biochemical Phenomena; Biochemistry; Chloromercuribenzoates; Enzyme Inhibitors; Ethylmaleimide; Isoniazid; Liver; Lung; Metabolism; Mice; N-Glycosyl Hydrolases; NAD; NAD+ Nucleosidase; Niacinamide; Research; Tuberculosis | 1965 |
[Influence of nicotinamide on the DPN-content, glycolysis and viability of ascites tumor cells after treatment with carcinostatic ethyleneimine compounds].
Topics: Animals; Antineoplastic Agents; Ascites; Aziridines; Coenzymes; Glycolysis; Humans; NAD; Neoplasms, Experimental; Niacin; Niacinamide | 1962 |
Influence of nicotic acid and nicotinamide on diphosphopyridine nucleotide (DPN) Synthesis in ascites tumor cells.
Topics: Animals; Ascites; Carcinoma, Ehrlich Tumor; Coenzymes; NAD; Neoplasms; Niacin; Niacinamide; Nicotinic Acids | 1961 |
Nicotinamide offers multiple protective mechanisms in stroke as a precursor for NAD+, as a PARP inhibitor and by partial restoration of mitochondrial function.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Disease Models, Animal; Mice; Mice, Inbred BALB C; Mitochondria; NAD; Neuroprotective Agents; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Reperfusion; Stroke | 2003 |
Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases.
Topics: Amino Acid Substitution; Catalysis; Glycosylation; Histone Deacetylases; Humans; Kinetics; Models, Chemical; NAD; Niacinamide; Pyridines; Ribose; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 1; Sirtuin 2; Sirtuins | 2003 |
Fluorometric studies of ligand-induced conformational changes of CD38.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Binding Sites; Humans; Hydrolysis; Kinetics; Ligands; Membrane Glycoproteins; Mice; Models, Molecular; NAD; Niacinamide; Protein Binding; Protein Conformation; Recombinant Proteins; Spectrometry, Fluorescence; Temperature; Tryptophan | 2003 |
FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis.
Topics: Acrylamides; Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Enzyme Inhibitors; Humans; K562 Cells; Kinetics; Liver Neoplasms; Mitochondria, Liver; NAD; Niacin; Niacinamide; Nicotinamide Phosphoribosyltransferase; Oxygen Consumption; Pentosyltransferases; Piperidines | 2003 |
Rational proteomics I. Fingerprint identification and cofactor specificity in the short-chain oxidoreductase (SCOR) enzyme family.
Topics: Amino Acid Sequence; Binding Sites; Catalytic Domain; Hydrogen Bonding; Models, Chemical; Models, Molecular; Molecular Sequence Data; NAD; NADP; Niacinamide; Oxidoreductases; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Proteomics; Sequence Homology, Amino Acid; Water | 2003 |
Toward the elucidation of the catalytic mechanism of the mono-ADP-ribosyltransferase activity of Pseudomonas aeruginosa exotoxin A.
Topics: 1-Naphthylamine; Adenosine Diphosphate; Adenosine Diphosphate Ribose; Adenosine Monophosphate; ADP Ribose Transferases; Bacterial Toxins; Binding, Competitive; Catalysis; Enzyme Activation; Exotoxins; Fluorescence Resonance Energy Transfer; Kinetics; Mutagenesis, Site-Directed; NAD; Naphthalimides; Niacinamide; Peptide Elongation Factor 2; Protein Binding; Pseudomonas aeruginosa; Pseudomonas aeruginosa Exotoxin A; Quinolones; Recombinant Proteins; Substrate Specificity; Virulence Factors | 2004 |
Synthesis and utility of 14C-labeled nicotinamide cofactors.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Carbon Isotopes; Chromatography, High Pressure Liquid; Creatinine; Isotope Labeling; NAD; NADP; Niacinamide; Phosphotransferases (Alcohol Group Acceptor) | 2004 |
Graded reoxygenation with chemical inhibition of oxidative phosphorylation improves posthypoxic recovery in murine hippocampal slices.
Topics: Action Potentials; Amobarbital; Animals; Cyanides; Electron Transport Complex I; Electron Transport Complex II; Electron Transport Complex IV; Hippocampus; Hypoxia; Male; Malonates; Mice; NAD; Niacinamide; Organ Culture Techniques; Oxidative Phosphorylation; Reperfusion | 2004 |
Effects of excess nicotinamide administration on the urinary excretion of nicotinamide N-oxide and nicotinuric acid by rats.
Topics: Animals; Dose-Response Relationship, Drug; Eating; Liver; Male; NAD; NADP; Niacinamide; Nicotinic Acids; Predictive Value of Tests; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan; Weaning; Weight Gain | 2004 |
Antidepressant-like effect of nicotinamide adenine dinucleotide in the forced swim test in rats.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depression; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Injections, Intraperitoneal; Male; Motor Activity; NAD; Niacinamide; Rats; Rats, Wistar; Swimming | 2004 |
Inhibition of diphosphopyridine nucleotide-requiring enzymes by nicotinamide.
Topics: Coenzymes; Enzymes; NAD; Niacin; Niacinamide; Pyridines | 1951 |
Scientific community. Aging research's family feud.
Topics: Aging; Animals; Australia; Biotechnology; Caloric Restriction; Histone Deacetylases; History, 20th Century; History, 21st Century; Humans; Longevity; NAD; Niacinamide; Nicotinamidase; Resveratrol; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Stilbenes; United States | 2004 |
Tracking variations in nicotinamide cofactors extracted from cultured cells using capillary electrophoresis with multiphoton excitation of fluorescence.
Topics: Animals; Cell Extracts; Cells, Cultured; Electrophoresis, Capillary; Microscopy, Fluorescence, Multiphoton; NAD; NADP; Niacinamide | 2004 |
Kinetic and structural analysis of the increased affinity of enoyl-ACP (acyl-carrier protein) reductase for triclosan in the presence of NAD+.
Topics: Alanine; Animals; Asparagine; Carbon-Carbon Ligases; Cloning, Molecular; Crystallography, X-Ray; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); NAD; Niacinamide; Oxidoreductases; Plasmodium falciparum; Protein Binding; Structure-Activity Relationship; Substrate Specificity; Surface Plasmon Resonance; Triclosan | 2004 |
Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans.
Topics: Chromosomes, Human, Pair 9; Energy Metabolism; Evolution, Molecular; Fungi; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Humans; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; NAD; Niacinamide; Nucleosides; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds; Ribavirin; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid | 2004 |
Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases.
Topics: Adenosine Diphosphate Ribose; Binding Sites; Histone Deacetylases; Models, Molecular; NAD; Niacinamide; Protein Conformation; Saccharomyces cerevisiae; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Thermodynamics | 2004 |
The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potential.
Topics: Animals; Binding Sites; Caspase 3; Caspase 9; Caspases; Cell Survival; Cytochromes c; DNA Fragmentation; Forkhead Transcription Factors; Membrane Potentials; Mice; Mitochondria; NAD; Neurons; Niacinamide; Nuclear Proteins; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Transcription Factors; Transfection | 2004 |
Fluorescence assay of SIRT protein deacetylases using an acetylated peptide substrate and a secondary trypsin reaction.
Topics: Chromatography, High Pressure Liquid; Fluorescent Dyes; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Kinetics; NAD; Niacinamide; Peptide Fragments; Sirtuin 1; Sirtuin 2; Sirtuins; Trypsin | 2004 |
DNA cleavage induced by thermal electron transfer from a dimeric NADH analogue to acridinium ions in the presence of oxygen.
Topics: Acridines; DNA; DNA Damage; Electron Spin Resonance Spectroscopy; Electrons; Kinetics; NAD; Niacinamide; Oxygen; Superoxides | 2004 |
NAD+ modulates p53 DNA binding specificity and function.
Topics: Adenosine Diphosphate; Animals; Cell Line; DNA; DNA Damage; Humans; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD; Niacinamide; Protein Binding; Protein Conformation; Protein Structure, Quaternary; Recombinant Proteins; Thiamine; Tumor Suppressor Protein p53 | 2004 |
Mechanistic aspects of the deoxyribonuclease activity of diphtheria toxin.
Topics: Adenosine; Adenosine Diphosphate Ribose; ADP Ribose Transferases; Azides; Binding Sites; Catalysis; Cations, Divalent; Cell Line; Cycloheximide; Diphtheria Toxin; DNA; Endodeoxyribonucleases; Humans; NAD; Niacinamide; Oligoribonucleotides; Peptide Elongation Factor 2; Protein Biosynthesis; Substrate Specificity | 2005 |
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}.
Topics: Acetylation; Animals; DNA-Binding Proteins; E1A-Associated p300 Protein; Forkhead Box Protein O1; Forkhead Transcription Factors; HeLa Cells; Humans; NAD; Nerve Tissue Proteins; Niacinamide; Nuclear Proteins; Oxygen Consumption; PC12 Cells; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; RNA-Binding Proteins; Sirtuin 1; Sirtuins; Trans-Activators; Transcription Factors; Tumor Suppressor Protein p53 | 2005 |
Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition.
Topics: Acetylation; Gene Expression Regulation, Fungal; Gene Silencing; Histone Deacetylase Inhibitors; Histone Deacetylases; NAD; Niacinamide; Nicotinamidase; Pentosyltransferases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Telomere; Transcription, Genetic | 2005 |
Nicotinic acid limitation regulates silencing of Candida adhesins during UTI.
Topics: Animals; Candida glabrata; Candidiasis; Cell Adhesion; Culture Media; Female; Gene Expression Regulation, Fungal; Gene Silencing; Genes, Fungal; Histone Deacetylases; Lectins; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; NAD; Niacin; Niacinamide; Sirtuins; Transcription, Genetic; Urinary Bladder; Urinary Tract Infections; Urine; Urothelium; Virulence | 2005 |
Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme.
Topics: Acetylation; Amino Acid Sequence; Catalysis; Gene Expression Regulation, Fungal; Histone Deacetylases; Molecular Sequence Data; NAD; Niacin; Niacinamide; Sequence Homology, Amino Acid; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Substrate Specificity; Vasodilator Agents | 2005 |
NAD deamidation "a new reaction" by an enzyme from Aspergillus terreus DSM 826.
Topics: Acetamides; Acrylic Resins; Asparagine; Aspergillus; Chromatography, Liquid; Deamination; Enzyme Inhibitors; Enzyme Stability; Freezing; Glutamine; Hydrogen-Ion Concentration; Kinetics; NAD; Niacinamide; Nicotinamide Mononucleotide; Pyridinium Compounds; Substrate Specificity; Temperature | 2005 |
Enhanced dihydroflavonol-4-reductase activity and NAD homeostasis leading to cell death tolerance in transgenic rice.
Topics: Alcohol Oxidoreductases; Amide Synthases; Cell Death; Coloring Agents; Electrophoresis, Capillary; Evans Blue; Glutathione Transferase; Homeostasis; Hydrogen-Ion Concentration; Ions; Mass Spectrometry; Models, Biological; NAD; NADP; Niacinamide; Oryza; Phosphotransferases (Alcohol Group Acceptor); Plant Leaves; Plants, Genetically Modified; Reactive Oxygen Species; Recombinant Fusion Proteins; Time Factors; Zea mays | 2005 |
Structural transformations in the dynamics of Michaelis complex formation in lactate dehydrogenase.
Topics: Binding Sites; Biophysics; Catalysis; Hydrogen Bonding; Kinetics; L-Lactate Dehydrogenase; Lasers; Models, Chemical; NAD; Niacinamide; Protein Conformation; Proteins; Spectrometry, Fluorescence; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Substrate Specificity; Temperature; Time Factors | 2005 |
Conversion ratio of tryptophan to niacin in Japanese women fed a purified diet conforming to the Japanese Dietary Reference Intakes.
Topics: Adult; Diet; Female; Humans; Japan; Male; NAD; NADP; Niacin; Niacinamide; Nutrition Policy; Sex Characteristics; Tryptophan | 2004 |
Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations.
Topics: Binding Sites; Catalysis; Cloning, Molecular; Crystallography, X-Ray; Databases, Protein; Dihydrolipoamide Dehydrogenase; Dimerization; Disulfides; Glycine; Humans; Maple Syrup Urine Disease; Models, Molecular; Mutation; NAD; Niacinamide; Oxygen; Potyvirus; Protein Binding; Pseudomonas putida; Saccharomyces cerevisiae; Thioctic Acid | 2005 |
Coupling of NAD+ biosynthesis and nicotinamide ribosyl transport: characterization of NadR ribonucleotide kinase mutants of Haemophilus influenzae.
Topics: Amino Acid Motifs; Bacterial Proteins; Catalytic Domain; Cell Membrane; Haemophilus influenzae; Mutation; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Pentosyltransferases; Phosphorylation; Phosphotransferases; Protein Transport; Pyridinium Compounds; Repressor Proteins; Ribonucleotides | 2005 |
A local mechanism mediates NAD-dependent protection of axon degeneration.
Topics: Adenosine Triphosphate; Animals; Axons; Cells, Cultured; Mice; NAD; Nerve Tissue Proteins; Niacinamide; Nicotinamide-Nucleotide Adenylyltransferase; Rats; Recombinant Fusion Proteins; Sirtuin 1; Sirtuins; Wallerian Degeneration | 2005 |
Microplate filtration assay for nicotinamide release from NAD using a boronic acid resin.
Topics: Acrylic Resins; Animals; Boronic Acids; Carbon Radioisotopes; Catalysis; Clinical Laboratory Techniques; Filtration; Histone Deacetylases; Humans; Hydrolysis; Kinetics; Models, Chemical; Molecular Structure; NAD; Niacinamide; Sirtuins | 2005 |
Ligand binding modulates the mechanical stability of dihydrofolate reductase.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Biophysical Phenomena; Biophysics; CHO Cells; Chromatography, Affinity; Cricetinae; Folic Acid; Folic Acid Antagonists; Humans; Ligands; Methotrexate; Microscopy, Atomic Force; NAD; NADP; Niacinamide; Proteasome Endopeptidase Complex; Protein Binding; Protein Conformation; Protein Denaturation; Protein Engineering; Protein Folding; Protein Transport; Spectrophotometry; Stress, Mechanical; Tensile Strength; Tetrahydrofolate Dehydrogenase; Thermodynamics | 2005 |
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.
Topics: Animals; Biological Availability; Carbazoles; Cell Membrane Permeability; CHO Cells; Cricetinae; Cricetulus; Drug Stability; Fluorometry; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; In Vitro Techniques; Indoles; Kinetics; Mice; Mice, Inbred C57BL; Microsomes, Liver; NAD; NAD+ Nucleosidase; Niacinamide; Rats; Recombinant Proteins; Sirtuin 1; Sirtuins; Stereoisomerism; Structure-Activity Relationship | 2005 |
MafA expression and insulin promoter activity are induced by nicotinamide and related compounds in INS-1 pancreatic beta-cells.
Topics: Antioxidants; Benzamides; Cells, Cultured; Enzyme Inhibitors; Homeodomain Proteins; Insulin; Insulin-Secreting Cells; Isoquinolines; Maf Transcription Factors, Large; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Promoter Regions, Genetic; RNA, Messenger; Trans-Activators | 2006 |
The simultaneous measurement of nicotinamide adenine dinucleotide and related compounds by liquid chromatography/electrospray ionization tandem mass spectrometry.
Topics: Adenosine Diphosphate Ribose; Adenosine Monophosphate; Animals; Chromatography, Liquid; Erythrocytes; HL-60 Cells; Humans; Mice; Mice, Inbred BALB C; NAD; Niacin; Niacinamide; Nicotinamide Mononucleotide; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2006 |
Comparative genomics of NAD biosynthesis in cyanobacteria.
Topics: Amide Synthases; Cyanobacteria; Escherichia coli; Gene Transfer, Horizontal; Genome, Bacterial; Glutamine; Models, Biological; Multigene Family; NAD; Niacin; Niacinamide; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Nucleotidyltransferases; Pentosyltransferases; Synteny | 2006 |
Accumulation of poly(ADP-ribose) polymerase inhibitors in children with chronic renal failure.
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Kidney Failure, Chronic; Male; NAD; Niacinamide; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases | 2006 |
Tryptophan-niacin metabolism in rat with puromycin aminonucleoside-induced nephrosis.
Topics: Animals; Carboxy-Lyases; Kidney; Liver; Male; NAD; Nephrosis; Niacin; Niacinamide; Puromycin Aminonucleoside; Rats; Rats, Wistar; Serum Albumin; Tryptophan; Weight Gain | 2006 |
Fingerprinting DHFR in single-molecule AFM studies.
Topics: Animals; Biophysical Phenomena; Biophysics; CHO Cells; Chromatography, Affinity; Cricetinae; Cricetulus; Folic Acid; Folic Acid Antagonists; Humans; Ligands; Methotrexate; Microscopy, Atomic Force; NAD; NADP; Niacinamide; Peptide Mapping; Proteasome Endopeptidase Complex; Protein Binding; Protein Conformation; Protein Denaturation; Protein Engineering; Protein Folding; Protein Transport; Spectrophotometry; Stress, Mechanical; Tensile Strength; Tetrahydrofolate Dehydrogenase; Thermodynamics | 2006 |
Comparison of metabolic fates of nicotinamide, NAD+ and NADH administered orally and intraperitoneally; characterization of oral NADH.
Topics: Acids; Administration, Oral; Animals; Body Weight; Chromatography, High Pressure Liquid; Eating; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Molecular Structure; NAD; Niacinamide; Oxides; Solutions | 2006 |
Molecular switch based on a biologically important redox reaction.
Topics: Alcohol Dehydrogenase; Benzoquinones; Borohydrides; Electrochemistry; Fluorescence; Molecular Structure; NAD; Niacinamide; Oxidation-Reduction; Perylene; Time Factors | 2005 |
The 2'-phosphate of NADP is responsible for proper orientation of the nicotinamide ring in the oxidative decarboxylation reaction catalyzed by sheep liver 6-phosphogluconate dehydrogenase.
Topics: Animals; Asparagine; Binding Sites; Glycosides; Humans; Hydrogen Bonding; Liver; Models, Molecular; NAD; NADP; Niacinamide; Oxygen; Phosphates; Phosphogluconate Dehydrogenase; Sheep; Threonine | 2006 |
Zinc neurotoxicity is dependent on intracellular NAD levels and the sirtuin pathway.
Topics: Aldehydes; Animals; Antioxidants; Brain Ischemia; Cells, Cultured; Flavonoids; Flavonols; Ion Channels; Male; Mitochondria; NAD; Naphthalenes; Neural Conduction; Neurotoxicity Syndromes; Neurotoxins; Niacinamide; Pyridines; Rats; Rats, Long-Evans; Resveratrol; Signal Transduction; Sirtuins; Stilbenes; Transcriptional Activation; Zinc | 2006 |
The novel nucleotide 4KNTP, in high concentrations in erythrocytes of renal failure children: a comparison with accumulation of other putative precursors in the plasma.
Topics: Adenosine Triphosphate; Adolescent; Child; Child, Preschool; Erythrocytes; Female; Hemofiltration; Humans; Male; NAD; Niacinamide; Nucleotides; Renal Insufficiency | 2006 |
Liquid chromatographic/mass spectrometric procedure for measurement of NAD catabolites in human and rat plasma and urine.
Topics: Animals; Chromatography; Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Mass Spectrometry; NAD; Niacinamide; Poly(ADP-ribose) Polymerases; Rats; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2006 |
Nicotinamidase participates in the salvage pathway of NAD biosynthesis in Arabidopsis.
Topics: Arabidopsis; Gene Expression; Metabolic Networks and Pathways; NAD; NADP; Niacinamide; Nicotinamidase; Nicotinamide Mononucleotide; Nicotinic Acids; Plant Roots | 2007 |
Pellagra: A clue as to why energy failure causes diseases?
Topics: Animals; Biochemistry; Diet; Humans; Infections; Inflammation; Metabolism; Models, Biological; Models, Theoretical; NAD; Niacinamide; Nutritional Status; Pellagra | 2007 |
Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis.
Topics: Cell Line; Cell Line, Tumor; Chlorides; Humans; Isoenzymes; Kinetics; Magnesium Chloride; NAD; Niacinamide; Nicotinamide-Nucleotide Adenylyltransferase; Pyridinium Compounds; Ribavirin; Substrate Specificity; Zinc Compounds | 2007 |
Vitamins and aging: pathways to NAD+ synthesis.
Topics: Aging; Animals; Histone Deacetylases; Humans; Longevity; NAD; Niacinamide; Pyridinium Compounds; Saccharomyces cerevisiae; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Vitamins | 2007 |
Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.
Topics: Gene Silencing; Histone Deacetylases; Metabolic Networks and Pathways; N-Glycosyl Hydrolases; NAD; Niacin; Niacinamide; Nicotinamidase; Phosphotransferases (Alcohol Group Acceptor); Purine-Nucleoside Phosphorylase; Pyridinium Compounds; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins | 2007 |
Nicotinamidase activity is important for germination.
Topics: ADP-ribosyl Cyclase; Amino Acid Sequence; Arabidopsis; Genome, Plant; Germination; Molecular Sequence Data; Mutation; NAD; Niacinamide; Nicotinamidase; Poly Adenosine Diphosphate Ribose; Seeds; Sequence Homology, Amino Acid | 2007 |
Mechanistic implications of the cysteine-nicotinamide adduct in aldehyde dehydrogenase based on quantum mechanical/molecular mechanical simulations.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Aldehydes; Computer Simulation; Cysteine; Humans; NAD; Niacinamide; Protein Conformation; Protons; Quantum Theory | 2007 |
Whole blood NAD and NADP concentrations are not depressed in subjects with clinical pellagra.
Topics: Adolescent; Adult; Female; Humans; Male; Middle Aged; NAD; NADP; Niacinamide; Pellagra; Pyridones; Sensitivity and Specificity; Time Factors | 2007 |
Assimilation of NAD(+) precursors in Candida glabrata.
Topics: Animals; Candida glabrata; Gene Deletion; Metabolic Networks and Pathways; Mice; N-Glycosyl Hydrolases; NAD; Niacin; Niacinamide; Nicotinamidase; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds | 2007 |
Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity.
Topics: ADP Ribose Transferases; Amino Acid Sequence; Animals; Genetic Complementation Test; Histone Deacetylases; Lysine; Models, Biological; Molecular Sequence Data; Mutation; NAD; Niacinamide; Plasmodium falciparum; Protozoan Proteins; Recombinant Proteins; Schizosaccharomyces pombe Proteins; Sequence Alignment; Sirtuins | 2007 |
Transformation products of extracellular NAD(+) in the rat liver: kinetics of formation and metabolic action.
Topics: Adenosine Diphosphate Ribose; Animals; Glucose; Infusion Pumps; Inosine; Liver; Male; NAD; Niacinamide; Pyruvic Acid; Rats; Rats, Wistar; Time Factors; Uric Acid | 2008 |
Syntheses of nicotinamide riboside and derivatives: effective agents for increasing nicotinamide adenine dinucleotide concentrations in mammalian cells.
Topics: Animals; Cell Line; Cell Line, Tumor; Cell Survival; Esters; Humans; Mice; NAD; Niacinamide; Nucleosides; Pyridinium Compounds; Structure-Activity Relationship | 2007 |
Saccharomyces cerevisiae YOR071C encodes the high affinity nicotinamide riboside transporter Nrt1.
Topics: Biological Transport; Hydrogen-Ion Concentration; Kinetics; Membrane Transport Proteins; Mutation; NAD; Niacinamide; Nucleoside Transport Proteins; Protein Binding; Pyridinium Compounds; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2008 |
The role of NAD+ depletion in the mechanism of sulfur mustard-induced metabolic injury.
Topics: Adenosine Triphosphate; Cell Count; Cell Survival; Cells, Cultured; Chemical Warfare Agents; Dose-Response Relationship, Drug; Energy Metabolism; Glucose; Glycolysis; Humans; Keratinocytes; Mustard Gas; NAD; Niacinamide; Time Factors; Vitamin B Complex | 2008 |
Nicorandil and ulcerations: a NAD/NADP and nicotinic acid-dependent side-effect?
Topics: Humans; NAD; NADP; Niacin; Niacinamide; Nicorandil; Ulcer; Vasodilator Agents | 2008 |
Design, synthesis, and evaluation of bisubstrate analog inhibitors of cholera toxin.
Topics: Antitoxins; Chemistry, Pharmaceutical; Cholera Toxin; Drug Design; Guanidine; Guanosine Triphosphate; Humans; Inhibitory Concentration 50; Kinetics; Models, Chemical; Molecular Conformation; NAD; Niacinamide; Structure-Activity Relationship; Substrate Specificity | 2008 |
Cytoprotective effects of nicotinamide derivatives in endothelial cells.
Topics: Cell Line; Cytoprotection; Endothelial Cells; Humans; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Time Factors | 2008 |
Sulphurous mineral water oral therapy: effects on erythrocyte metabolism.
Topics: Adult; Erythrocytes; Gene Expression Regulation, Enzymologic; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Hydrogen Sulfide; Mineral Waters; Molecular Structure; NAD; Niacinamide; Protein Processing, Post-Translational; Time Factors | 2008 |
Pnc1p-mediated nicotinamide clearance modifies the epigenetic properties of rDNA silencing in Saccharomyces cerevisiae.
Topics: DNA, Ribosomal; Gene Silencing; Histone Deacetylases; NAD; Niacinamide; Nicotinamidase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Telomere | 2008 |
A SIR-tain acetyl complex is caught by a sulfur trap.
Topics: Acetates; Bacteria; Catalytic Domain; Humans; Imidoesters; Models, Biological; Multiprotein Complexes; NAD; Niacinamide; Phenylalanine; Protein Binding; Sirtuins; Sulfur | 2008 |
Separation of flavins and nicotinamide cofactors in Chinese hamster ovary cells by capillary electrophoresis.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Electrophoresis, Capillary; Flavins; NAD; NADP; Niacinamide; Reproducibility of Results; Spectrometry, Fluorescence | 2008 |
Engineering cytochrome P450 enzymes for improved activity towards biomimetic 1,4-NADH cofactors.
Topics: Bacterial Proteins; Biocatalysis; Biomimetic Materials; Camphor 5-Monooxygenase; Coenzymes; Cytochrome P-450 Enzyme System; NAD; NADPH-Ferrihemoprotein Reductase; Niacinamide; Oxidation-Reduction; Protein Engineering; Pseudomonas putida | 2008 |
The relationship between pyridine nucleotides and seed dormancy.
Topics: Arabidopsis; Cabo Verde; DNA-Directed DNA Polymerase; Gene Expression; Germination; NAD; NADP; Niacinamide; Nicotinamidase; Nucleotidases; Nucleotides; Phosphotransferases (Alcohol Group Acceptor); Poly(ADP-ribose) Polymerases; Seeds | 2009 |
Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism.
Topics: Histone Deacetylases; Humans; NAD; Niacinamide; Phosphotransferases (Alcohol Group Acceptor); Purine-Nucleoside Phosphorylase; Saccharomyces cerevisiae; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins | 2009 |
Changes in pyridine metabolism profile during growth of trigonelline-forming Lotus japonicus cell cultures.
Topics: Alkaloids; Carbon Radioisotopes; Cells, Cultured; Gene Expression Regulation, Plant; Lotus; NAD; Niacinamide; Nicotinamidase; Plant Proteins; Pyridines; Quinolinic Acid; Time Factors; Tritium | 2008 |
Transformation and action of extracellular NAD+ in perfused rat and mouse livers.
Topics: Adenosine Diphosphate Ribose; Adenosine Monophosphate; Animals; Chromatography, High Pressure Liquid; Gluconeogenesis; Inosine; Liver; Male; Mice; NAD; Niacinamide; Oxygen Consumption; Perfusion; Rats; Rats, Sprague-Dawley; Rats, Wistar; Uric Acid | 2009 |
NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway.
Topics: Cell Differentiation; Cytokines; Granulocyte Colony-Stimulating Factor; Granulocytes; Hematopoiesis; HL-60 Cells; Humans; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Receptors, Granulocyte Colony-Stimulating Factor; Sirtuin 1; Sirtuins | 2009 |
Comparison of the nicotinamide catabolism among rat strains.
Topics: Animals; Body Weight; Eating; Male; NAD; NADP; Niacinamide; Rats; Rats, Inbred Strains; Solubility; Species Specificity; Tryptophan; Vitamins; Water | 2009 |
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1.
Topics: Acrylamides; Animals; ARNTL Transcription Factors; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Cell Line; Chromatin Assembly and Disassembly; Circadian Rhythm; CLOCK Proteins; Cytokines; Enzyme Inhibitors; Feedback, Physiological; Gene Expression Regulation; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Promoter Regions, Genetic; Sirtuin 1; Sirtuins; Trans-Activators; Transcription, Genetic | 2009 |
Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons.
Topics: Animals; Antioxidants; Brain Ischemia; Cell Death; Cells, Cultured; Male; Mice; Mice, Inbred C57BL; NAD; Neurons; Neuroprotective Agents; Neurotoxins; Niacinamide; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Resveratrol; Sirtuin 1; Sirtuins; Stilbenes | 2009 |
Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Small Cell; Cell Line, Tumor; Colonic Neoplasms; Cyanides; Cytokines; Drug Screening Assays, Antitumor; Female; Guanidines; Humans; Infusions, Intravenous; Injections, Intravenous; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, SCID; Multiple Myeloma; NAD; Neoplasm Proteins; Niacin; Niacinamide; Nicotinamide Phosphoribosyltransferase; Prodrugs; Xenograft Model Antitumor Assays | 2009 |
Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae.
Topics: Animals; Caloric Restriction; Genes, Fungal; Histone Deacetylases; Hot Temperature; Longevity; Mammals; Models, Biological; Mutation; N-Glycosyl Hydrolases; NAD; Niacinamide; Pentosyltransferases; Pyridinium Compounds; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Stress, Physiological; Time Factors | 2009 |
Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo.
Topics: Acetophenones; Acrylamides; Animals; Cell Survival; Chromatography, High Pressure Liquid; Cytokines; Enzyme Inhibitors; Formates; HeLa Cells; Humans; Male; Mice; NAD; Niacinamide; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Organ Specificity; Piperidines; U937 Cells | 2009 |
Induced fit and equilibrium dynamics for high catalytic efficiency in ferredoxin-NADP(H) reductases.
Topics: Binding Sites; Catalysis; Crystallography, X-Ray; Escherichia coli; Ferredoxin-NADP Reductase; Kinetics; Ligands; Models, Molecular; NAD; Niacinamide; Pisum sativum; Plant Proteins; Protein Conformation; Structure-Activity Relationship | 2009 |
Consideration of diurnal variations in human blood NAD and NADP concentrations.
Topics: Adult; Circadian Rhythm; Diet; Humans; Male; NAD; NADP; Niacinamide | 2009 |
A continuous microplate assay for sirtuins and nicotinamide-producing enzymes.
Topics: ADP-ribosyl Cyclase 1; Amino Acid Sequence; Animals; Cattle; Cell Extracts; Cell Line; Enzyme Inhibitors; Enzymes; Glutamate Dehydrogenase; Humans; Kinetics; Linear Models; NAD; NADP; Niacinamide; Peptides; Sequence Homology; Sirtuins; Spectrometry, Fluorescence; Spectrum Analysis; Time Factors | 2009 |
Mechanistic insights on the magnesium(II) ion-activated reduction of methyl benzoylformate with chelated NADH peptide beta-lactam models.
Topics: beta-Lactams; Cations; Chelating Agents; Chemistry, Organic; Glyoxylates; Ions; Magnesium; Mandelic Acids; Molecular Conformation; Molecular Structure; NAD; Niacinamide; Peptides; Stereoisomerism | 2009 |
Bipartite recognition and conformational sampling mechanisms for hydride transfer from nicotinamide coenzyme to FMN in pentaerythritol tetranitrate reductase.
Topics: Coenzymes; Flavin Mononucleotide; Kinetics; NAD; NADP; Niacinamide; Oxidoreductases; Protein Conformation; Substrate Specificity | 2009 |
Mechanistic studies on the effects of nicotinamide on megakaryocytic polyploidization and the roles of NAD+ levels and SIRT inhibition.
Topics: Acetylation; Aneugens; Apoptosis; Cell Culture Techniques; Cells, Cultured; Consensus Sequence; Cytokines; DNA; Humans; Megakaryocytes; NAD; Naphthalenes; Niacinamide; Nucleosomes; Polyploidy; Protein Binding; Protein Processing, Post-Translational; Pyrimidinones; Sirtuin 1; Sirtuin 2; Tumor Suppressor Protein p53 | 2009 |
SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Enzyme Activators; Enzyme Inhibitors; Gene Expression Regulation, Viral; Gene Knockdown Techniques; HIV-1; Host-Pathogen Interactions; Humans; NAD; Niacinamide; Resveratrol; RNA, Small Interfering; Sirtuin 1; Stilbenes; tat Gene Products, Human Immunodeficiency Virus; Transcriptional Activation | 2009 |
Niacin status impacts chromatin structure.
Topics: Adenosine Diphosphate Ribose; Chromatin; Diet; Epigenesis, Genetic; Gene Expression Regulation; Histones; Humans; NAD; Niacin; Niacinamide; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Sirtuins | 2009 |
Nicotinamidase modulation of NAD+ biosynthesis and nicotinamide levels separately affect reproductive development and cell survival in C. elegans.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Survival; Female; NAD; Niacinamide; Nicotinamidase; Ovum; Uterus | 2009 |
Profiles of the biosynthesis and metabolism of pyridine nucleotides in potatoes (Solanum tuberosum L.).
Topics: Carbon Isotopes; NAD; Niacinamide; Nucleotides; Organ Specificity; Plant Leaves; Plant Tubers; Quinolinic Acid; Solanum tuberosum; Time Factors; Tissue Extracts; Tritium | 2009 |
Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside.
Topics: 5'-Nucleotidase; Gene Knockout Techniques; Glucose; NAD; Niacin; Niacinamide; Nicotinamide Mononucleotide; Pyridinium Compounds; Ribonucleosides; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Vitamins | 2009 |
Pyridine salvage and nicotinic acid conjugate synthesis in leaves of mangrove species.
Topics: Alkaloids; Avicennia; Deamination; Decarboxylation; Glucosides; Isotopes; NAD; NADP; Niacinamide; Nicotinic Acids; Nucleotides; Plant Leaves; Plant Roots; Pyridines; Rhizophoraceae; Salt Tolerance; Sodium Chloride | 2010 |
Nicotinamide overload may play a role in the development of type 2 diabetes.
Topics: Adult; Aged; Aldehyde Oxidase; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Erythrocytes; Female; Humans; Hydrogen Peroxide; Insulin; Male; Middle Aged; NAD; Niacinamide; Oxidants; Random Allocation; Rats; Rats, Sprague-Dawley; Risk Factors; Sweat; Young Adult | 2009 |
NAD+ auxotrophy is bacteriocidal for the tubercle bacilli.
Topics: Animals; Biosynthetic Pathways; Colony Count, Microbial; Disease Models, Animal; Mice; Microbial Viability; Models, Biological; Mycobacterium bovis; Mycobacterium tuberculosis; NAD; Niacinamide; Tuberculosis; Virulence | 2010 |
Effect of selected NAD+ analogues on mitochondria activity and proliferation of endothelial EA.hy926 cells.
Topics: Adenosine Triphosphate; Biological Transport; Calcium; Cell Cycle; Cell Line; Cell Proliferation; Cell Survival; Cytosol; Endothelial Cells; Humans; Membrane Potential, Mitochondrial; Mitochondria; NAD; Niacinamide; Oxygen; Pyridines; Pyridinium Compounds | 2010 |
Role of CD38, a cyclic ADP-ribosylcyclase, in morphine antinociception and tolerance.
Topics: ADP-ribosyl Cyclase 1; Analgesics, Opioid; Animals; Cyclic ADP-Ribose; Dose-Response Relationship, Drug; Drug Tolerance; Hot Temperature; Hypothermia; Immersion; Injections, Intraventricular; Male; Mice; Mice, Knockout; Morphine; Motor Activity; NAD; Niacinamide; Pain; Pain Measurement; Reaction Time; Ryanodine Receptor Calcium Release Channel | 2010 |
Growth of M. avium subspecies paratuberculosis in culture is enhanced by nicotinic acid, nicotinamide, and α and β nicotinamide adenine dinucleotide.
Topics: Colitis, Ulcerative; Crohn Disease; Culture Media; Humans; Mycobacterium avium subsp. paratuberculosis; NAD; Niacin; Niacinamide; Nicotiana | 2011 |
NADH oxidase activity of Bacillus subtilis nitroreductase NfrA1: insight into its biological role.
Topics: Amino Acid Sequence; Bacillus subtilis; Bacterial Proteins; Cloning, Molecular; Hydrogen Peroxide; Molecular Sequence Data; Multienzyme Complexes; NAD; NADH, NADPH Oxidoreductases; Niacinamide; Nitroreductases; Oxidative Stress; Protein Conformation; Superoxides | 2010 |
The specificity of proton-translocating transhydrogenase for nicotinamide nucleotides.
Topics: Amino Acid Substitution; Binding Sites; Escherichia coli; Kinetics; NAD; NADP; NADP Transhydrogenases; Niacinamide; Oxidation-Reduction; Recombinant Proteins; Rhodospirillum rubrum; Substrate Specificity | 2011 |
Synthesizing and salvaging NAD: lessons learned from Chlamydomonas reinhardtii.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; Biological Evolution; Biosynthetic Pathways; Chlamydomonas reinhardtii; Gene Expression Regulation; Gene Expression Regulation, Plant; Genes, Plant; Mammals; Molecular Sequence Data; Mutagenesis, Insertional; Mutation; NAD; Niacinamide; Nicotinamide-Nucleotide Adenylyltransferase; Phenotype; Plant Proteins; Pyridines; Time Factors; Transcription, Genetic | 2010 |
Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin and of nicotinamide as a corrective agent for this effect.
Topics: Animals; Chick Embryo; Cytochrome P-450 CYP1A1; Gene Silencing; Glucose; Glycogen; Hepatocytes; Liver; NAD; Niacinamide; Poly(ADP-ribose) Polymerases; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Sirtuin 1; Transcription Factors | 2010 |
Muscle type-specific responses to NAD+ salvage biosynthesis promote muscle function in Caenorhabditis elegans.
Topics: Animals; Biosynthetic Pathways; Caenorhabditis elegans; Crosses, Genetic; Genitalia, Male; Male; Muscle Development; Mutation; NAD; Niacinamide; Nicotinamidase; Sexual Behavior, Animal | 2011 |
Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism.
Topics: Acetyl-CoA Carboxylase; Animals; Carbazoles; Cholesterol; Fructose; Gluconeogenesis; Hepatocytes; Heterocyclic Compounds, 4 or More Rings; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Lipogenesis; Male; NAD; Niacinamide; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphoenolpyruvate Carboxykinase (ATP); Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Rotenone; Sirtuin 1; Sterol Regulatory Element Binding Protein 1; Transcription Factors | 2011 |
Effects of 1-methylnicotinamide and its metabolite N-methyl-2-pyridone-5-carboxamide on streptozotocin-induced toxicity in murine insulinoma MIN6 cell line.
Topics: Adenosine Triphosphate; Animals; Cell Line, Tumor; Cell Survival; Insulinoma; Mice; NAD; Niacinamide; Pyridones; Streptozocin | 2011 |
Caloric restriction primes mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of the electron transport chain.
Topics: Acetylation; Animals; Antioxidants; Blotting, Western; Caloric Restriction; Cells, Cultured; Disease Models, Animal; Electron Transport Chain Complex Proteins; Electron Transport Complex III; Humans; Hydrogen Peroxide; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Myocytes, Cardiac; NAD; NADH Dehydrogenase; Niacinamide; Oxidative Stress; Proteomics; Rats; Rats, Inbred F344; Resveratrol; Sirtuins; Stilbenes | 2011 |
Liquid chromatography/time-of-flight mass spectrometry for the analysis of plant samples: a method for simultaneous screening of common cofactors or nucleotides and application to an engineered plant line.
Topics: Adenosine Triphosphate; Arabidopsis; Bacteria; Chromatography, Liquid; Magnetic Resonance Spectroscopy; NAD; Niacin; Niacinamide; Pentosyltransferases; Photosynthesis; Plant Extracts; Plant Leaves; Plants, Genetically Modified; Quinolinic Acid; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2011 |
Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Cloning, Molecular; Enzyme Activation; Escherichia coli; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Niacin; Niacinamide; Nicotinamide Mononucleotide; Pentosyltransferases; Plasmids; Recombinant Proteins; Structural Homology, Protein; Sugar Phosphates | 2012 |
Nicotinamide phosphoribosyltransferase (Nampt) affects the lineage fate determination of mesenchymal stem cells: a possible cause for reduced osteogenesis and increased adipogenesis in older individuals.
Topics: Adipocytes; Adipogenesis; Aging; Animals; Bone Marrow Cells; Carbazoles; Cell Line; Cell Lineage; Culture Media; Cytokines; Humans; Intracellular Space; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Osteogenesis; Sirtuin 1; Stromal Cells | 2011 |
NAD+ treatment induces delayed autophagy in Neuro2a cells partially by increasing oxidative stress.
Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Survival; Mice; Microtubule-Associated Proteins; NAD; Neuroblastoma; Niacinamide; Oxidative Stress; Tumor Cells, Cultured | 2011 |
Pre-B-cell colony-enhancing factor exerts a neuronal protection through its enzymatic activity and the reduction of mitochondrial dysfunction in in vitro ischemic models.
Topics: Acrylamides; Animals; Brain; Cell Death; Cells, Cultured; DNA, Mitochondrial; Embryo, Mammalian; Female; Glucose; Glutamic Acid; Hypoxia; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; Mutation; NAD; Neurons; Neuroprotective Agents; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Pregnancy | 2012 |
Pyridine metabolism and trigonelline synthesis in leaves of the mangrove legume trees Derris indica (Millettia pinnata) and Caesalpinia crista.
Topics: Alkaloids; Caesalpinia; Derris; NAD; Niacin; Niacinamide; Plant Leaves; Pyridines | 2011 |
[Nicorandil and ulceration: a physiopathological hypothesis].
Topics: Angina Pectoris; Drug Eruptions; Humans; NAD; NADP; Niacin; Niacinamide; Nicorandil; Skin; Skin Ulcer; Vasodilator Agents | 2012 |
NAD(+) biosynthesis and salvage--a phylogenetic perspective.
Topics: Adenosine Diphosphate Ribose; Animals; Eukaryota; Humans; Metabolic Networks and Pathways; NAD; Niacinamide; Phosphotransferases (Alcohol Group Acceptor); Phylogeny; Protein Processing, Post-Translational; Saccharomyces cerevisiae | 2012 |
A flavoprotein monooxygenase that catalyses a Baeyer-Villiger reaction and thioether oxidation using NADH as the nicotinamide cofactor.
Topics: Amino Acid Sequence; Animals; Catalysis; Flavoproteins; Molecular Sequence Data; NAD; NADP; Niacinamide; Oxidation-Reduction; Oxygenases; Stenotrophomonas maltophilia; Substrate Specificity; Sulfides | 2012 |
Pyridine metabolism in tea plants: salvage, conjugate formation and catabolism.
Topics: Alkaloids; Camellia sinensis; Carbon Dioxide; Carbon Radioisotopes; Enzyme Activation; Enzyme Assays; Glutarates; NAD; NADP; Niacin; Niacinamide; Plant Leaves; Plant Proteins; Ribonucleosides; Seedlings | 2012 |
Isonicotinamide enhances Sir2 protein-mediated silencing and longevity in yeast by raising intracellular NAD+ concentration.
Topics: DNA, Fungal; DNA, Ribosomal; Gene Silencing; Genetic Loci; NAD; Niacinamide; Nicotinamidase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2 | 2012 |
A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons.
Topics: Adenine Nucleotides; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Chromatography, High Pressure Liquid; Cytochromes c; Disease Models, Animal; Glutathione; Hippocampus; Humans; Hydrogen Peroxide; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; NAD; Neurons; Niacinamide; Oxidants; Oxidation-Reduction; Presenilin-1; Reactive Oxygen Species; tau Proteins; Vitamin B Complex | 2012 |
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
Topics: Acrylamides; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; AMP-Activated Protein Kinases; Animals; Blotting, Western; Carbazoles; Cell Line, Tumor; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; HEK293 Cells; Hep G2 Cells; Humans; Mice; Mice, Knockout; Models, Biological; Mutation; NAD; Niacinamide; Phosphorylation; Piperidines; Resveratrol; RNA Interference; Signal Transduction; Sirtuin 1; Stilbenes | 2012 |
Leishmania infantum nicotinamidase is required for late-stage development in its natural sand fly vector, Phlebotomus perniciosus.
Topics: Animals; Female; Gene Deletion; Leishmania infantum; NAD; Niacin; Niacinamide; Nicotinamidase; Phlebotomus | 2012 |
Mitochondrial inhibitor models of Huntington's disease and Parkinson's disease induce zinc accumulation and are attenuated by inhibition of zinc neurotoxicity in vitro or in vivo.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Carrier Proteins; Cation Transport Proteins; Cell Death; Cells, Cultured; Cerebral Cortex; Dihydroxyacetone Phosphate; Disease Models, Animal; Drug Interactions; Embryo, Mammalian; Fructose-Bisphosphatase; Humans; Huntington Disease; Male; Matrix Metalloproteinase 16; Membrane Proteins; Membrane Transport Proteins; Mental Disorders; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mice, Transgenic; NAD; Neurons; Niacinamide; Nitro Compounds; Oxidopamine; Parkinson Disease; Propionates; Pyruvic Acid; Rats; Rats, Long-Evans; Tyrosine 3-Monooxygenase; Zinc | 2013 |
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.
Topics: Acetylation; Adipose Tissue, Brown; Animals; Brain; Diet, High-Fat; Dietary Supplements; Electron Transport Complex I; Energy Metabolism; HEK293 Cells; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria; Muscle, Skeletal; NAD; Niacinamide; Obesity; Organ Specificity; Oxidation-Reduction; Oxygen Consumption; Protein Processing, Post-Translational; Pyridinium Compounds; Receptors, G-Protein-Coupled; Receptors, Nicotinic; Sirtuin 1; Sirtuin 3; Superoxide Dismutase; Weight Gain | 2012 |
Comparison of the formation of nicotinic acid conjugates in leaves of different plant species.
Topics: Alkaloids; Carbon Radioisotopes; Embryophyta; Glucosides; NAD; Niacin; Niacinamide; Nicotinamide Mononucleotide; Plant Leaves; Species Specificity; Time Factors | 2012 |
Suppression of electron transfer to dioxygen by charge transfer and electron transfer complexes in the FAD-dependent reductase component of toluene dioxygenase.
Topics: Bacterial Proteins; Crystallography, X-Ray; Electron Transport; Ferredoxins; Flavin-Adenine Dinucleotide; Flavins; Kinetics; Models, Molecular; Multiprotein Complexes; NAD; Niacinamide; Oxidation-Reduction; Oxidoreductases; Oxygen; Oxygenases; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Pseudomonas putida; Static Electricity | 2012 |
Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.
Topics: Acetylation; Amino Acid Sequence; Animals; Humans; Mass Spectrometry; Methionine; Models, Molecular; Molecular Sequence Data; NAD; Niacinamide; Sirtuin 2; Sirtuins; Staining and Labeling; Zebrafish | 2012 |
Enhancement of tacrolimus productivity in Streptomyces tsukubaensis by the use of novel precursors for biosynthesis.
Topics: Biotechnology; Culture Media; Fermentation; Kinetics; NAD; NADP; Niacin; Niacinamide; Picolinic Acids; Streptomyces; Tacrolimus | 2012 |
Structural diversity of new C13-polyketides produced by Chaetomium mollipilium cultivated in the presence of a NAD(+)-dependent histone deacetylase inhibitor.
Topics: Antineoplastic Agents, Phytogenic; Chaetomium; Crystallography, X-Ray; Group III Histone Deacetylases; HCT116 Cells; Histone Deacetylase Inhibitors; Humans; Molecular Structure; NAD; Niacinamide; Nuclear Magnetic Resonance, Biomolecular; Polyketides | 2012 |
Establishment of true niacin deficiency in quinolinic acid phosphoribosyltransferase knockout mice.
Topics: Animals; Body Weight; Disease Models, Animal; Eating; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD; Niacin; Niacinamide; Pentosyltransferases; Quinolinic Acid | 2012 |
Mimicking nature: synthetic nicotinamide cofactors for C═C bioreduction using enoate reductases.
Topics: Catalysis; Combinatorial Chemistry Techniques; Molecular Mimicry; Molecular Structure; NAD; Niacinamide; Oxidoreductases Acting on CH-CH Group Donors | 2013 |
NAD(+) maintenance attenuates light induced photoreceptor degeneration.
Topics: Animals; Antioxidants; Cell Death; Cells, Cultured; Circadian Rhythm; Cytoprotection; Disease Models, Animal; Feeding Behavior; Hydrogen Peroxide; Light; Mice; Mice, Inbred C57BL; Mice, Transgenic; NAD; Niacinamide; Nicotinamide-Nucleotide Adenylyltransferase; Oxidants; Oxidative Stress; Photoreceptor Cells, Vertebrate; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Retinal Degeneration; Time Factors; Zinc | 2013 |
Catalytic contribution of threonine 244 in human ALDH2.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Amino Acid Substitution; Catalysis; Catalytic Domain; Coenzymes; Humans; Kinetics; NAD; Niacinamide; Protein Binding; Protein Structure, Secondary; Threonine | 2013 |
NAD+ salvage pathway proteins suppress proteotoxicity in yeast models of neurodegeneration by promoting the clearance of misfolded/oligomerized proteins.
Topics: alpha-Synuclein; Gene Expression; Histone Deacetylases; Mitochondria; NAD; Niacinamide; Nicotinamide-Nucleotide Adenylyltransferase; Oxidative Phosphorylation; Peptides; Protein Folding; Saccharomyces cerevisiae; Wallerian Degeneration | 2013 |
NAD+ and nicotinamide: sex differences in cerebral ischemia.
Topics: Analysis of Variance; Animals; Brain Ischemia; Caspase 3; Disease Models, Animal; Female; Male; Mice; Mice, Knockout; NAD; Niacinamide; Ovariectomy; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Sex Characteristics; Spectrin; Subcellular Fractions | 2013 |
The influence of B-complex vitamins upon the prolongation of prothrombin time by acetaldehyde.
Topics: Acetaldehyde; Alcoholism; Amines; Anticoagulants; Ethanol; Humans; NAD; Niacinamide; Prothrombin Time; Schiff Bases; Vitamin B Complex; Vitamin B Deficiency | 2013 |
Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression.
Topics: Acrylamides; Animals; Autophagy; Autophagy-Related Protein 5; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytokines; Disease Progression; Electron Transport Complex I; Female; Gene Knockdown Techniques; Humans; Lung Neoplasms; Mammary Neoplasms, Experimental; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred BALB C; Mice, SCID; Microtubule-Associated Proteins; Mitochondria; Multiprotein Complexes; NAD; Neoplasm Transplantation; Niacin; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Protein Transport; Proteins; Recombinant Proteins; Saccharomyces cerevisiae Proteins; TOR Serine-Threonine Kinases | 2013 |
NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity.
Topics: Acrylamides; Animals; Bone and Bones; Cell Differentiation; Coculture Techniques; Cytokines; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Mice; Mice, SCID; Multiple Myeloma; NAD; Neoplasm Proteins; NF-kappa B; Niacinamide; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Osteoclasts; Osteolysis; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Rabbits; Sirtuin 1; Tumor Cells, Cultured; Up-Regulation | 2013 |
NAD(+) influx through connexin hemichannels prevents poly(ADP-ribose) polymerase-mediated astrocyte death.
Topics: Adenosine; Animals; Astrocytes; Biological Transport; Cell Death; Cell Survival; Cells, Cultured; Connexins; Methylnitronitrosoguanidine; Mice; NAD; Niacinamide; Poly(ADP-ribose) Polymerases; Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7 | 2013 |
Nicotinamide overcomes pluripotency deficits and reprogramming barriers.
Topics: Apoptosis; Cell Line; Cell Proliferation; Cellular Reprogramming; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulation; Humans; Induced Pluripotent Stem Cells; Kinetics; Membrane Potential, Mitochondrial; NAD; Neoplasm Proteins; Niacin; Niacinamide; Oxidative Stress; Pluripotent Stem Cells; Reactive Oxygen Species; Tumor Suppressor Protein p53 | 2013 |
Protective effect of nicotinamide on high glucose/palmitate-induced glucolipotoxicity to INS-1 beta cells is attributed to its inhibitory activity to sirtuins.
Topics: Acetylcysteine; Animals; Antioxidants; Cell Death; Cell Line, Tumor; Cell Survival; Ephrin-B2; Gene Knockdown Techniques; Glucose; Glutathione; Insulin-Secreting Cells; MAP Kinase Kinase 4; NAD; Niacinamide; Palmitates; Phosphorylation; Poly Adenosine Diphosphate Ribose; Proto-Oncogene Proteins c-akt; Rats; Sirtuin 3; Sirtuins; Transcription Factor CHOP | 2013 |
Benzophenones from an endophytic fungus, Graphiopsis chlorocephala, from Paeonia lactiflora cultivated in the presence of an NAD+-dependent HDAC inhibitor.
Topics: Ascomycota; Benzophenones; Crystallography, X-Ray; Histone Deacetylase Inhibitors; Molecular Conformation; NAD; Niacinamide; Nuclear Magnetic Resonance, Biomolecular; Paeonia; Plant Leaves; X-Ray Diffraction | 2013 |
Cycling assay for determining intracellular cyclic adp-ribose levels.
Topics: ADP-ribosyl Cyclase; Alcohol Dehydrogenase; Cyclic ADP-Ribose; Cytoplasm; Ethanol; NAD; NADH Dehydrogenase; Niacinamide; Oxazines; Xanthenes | 2013 |
Practical application of cellular bioenergetics to the care of aged skin.
Topics: Adult; Cells, Cultured; Collagen Type I; Energy Metabolism; Female; Fibroblasts; Humans; Infant, Newborn; Male; Middle Aged; NAD; Niacinamide; Oligopeptides; Olive Oil; Plant Extracts; Plant Oils; RNA, Messenger; Skin; Skin Aging | 2013 |
Mitigation of gamma-radiation induced abasic sites in genomic DNA by dietary nicotinamide supplementation: metabolic up-regulation of NAD(+) biosynthesis.
Topics: Animals; Base Sequence; Cell Transformation, Neoplastic; Dietary Supplements; Gamma Rays; Genome; Male; Mice; Mutagenesis; NAD; Niacinamide; Radiation Dosage; Sequence Deletion; Up-Regulation | 2013 |
Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 induce different age-related metabolic profiles revealed by 1H-NMR spectroscopy in urine and feces of mice.
Topics: Age Factors; Aging; Animals; Bifidobacterium; Feces; Homocysteine; Intestines; Lactobacillus acidophilus; Magnetic Resonance Spectroscopy; Male; Metabolic Networks and Pathways; Metabolome; Mice; Mice, Inbred BALB C; NAD; Niacin; Niacinamide; Pentanoic Acids; Phenylacetates; Probiotics; Sarcosine; Xylose | 2013 |
Dual-energy precursor and nuclear erythroid-related factor 2 activator treatment additively improve redox glutathione levels and neuron survival in aging and Alzheimer mouse neurons upstream of reactive oxygen species.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Cells, Cultured; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Glutamate-Cysteine Ligase; Glutathione; Glycyrrhetinic Acid; Mice, Inbred C57BL; Mice, Transgenic; Molecular Targeted Therapy; NAD; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Niacinamide; Oxidation-Reduction; Reactive Oxygen Species | 2014 |
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Topics: Amides; Animals; Binding Sites; Carboxylic Acids; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Cytokines; Enzyme Inhibitors; Female; Half-Life; Haplorhini; Humans; Mice; Mice, Nude; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Protein Structure, Tertiary; Pyrazoles; Pyridines; Rats; Retina; Structure-Activity Relationship; Sulfones; Transplantation, Heterologous | 2013 |
Enzymes that control the conversion of L-tryptophan-nicotinamide and the urinary excretion ratio (N(1)-methyl-2-pyridone-5-carboxamide + N(1)-methyl-4-pyridone-3-carboxamide)/N(1)-methylnicotinamide in mice.
Topics: Animals; Body Weight; Eating; Enzymes; Male; Mice; NAD; Niacinamide; Pyridones; Quinolinic Acid; Tryptophan | 2013 |
Sirtuins: Longevity focuses on NAD+.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Forkhead Transcription Factors; Longevity; Mitochondria; NAD; Niacinamide; Signal Transduction; Sirtuins; Unfolded Protein Response | 2013 |
Nicotinamide pre-treatment ameliorates NAD(H) hyperoxidation and improves neuronal function after severe hypoxia.
Topics: Adenosine Triphosphate; Animals; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Male; Mitochondria; NAD; Neurons; Neuroprotective Agents; Niacinamide; Rats; Rats, Inbred F344 | 2014 |
Hepatectomy-related hypophosphatemia: a novel phosphaturic factor in the liver-kidney axis.
Topics: Acrylamides; Animals; Hepatectomy; Hypophosphatemia; Kidney; Male; Mice; Mice, Inbred C57BL; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Parathyroidectomy; Piperidines; Rats; Rats, Wistar; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type IIa | 2014 |
Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; DNA, Mitochondrial; Energy Metabolism; Glucose; Glucose Tolerance Test; Insulin Resistance; Liver; Male; Mitochondrial Turnover; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Obesity; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Inbred OLETF; Signal Transduction; Sirtuin 1; Sirtuins; Transcription Factors | 2014 |
Discovery of a novel nicotinamide phosphoribosyl transferase (NAMPT) inhibitor via in silico screening.
Topics: Animals; Antineoplastic Agents; Apoptosis; Computer Simulation; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; K562 Cells; Leukemia; Mice; NAD; Niacinamide; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase | 2014 |
Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vivo efficacy in NAPRT1-deficient tumor models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cytokines; Drug Synergism; Female; Gene Expression; Heterocyclic Compounds, 2-Ring; Humans; Mice; Mice, Nude; NAD; Niacin; Niacinamide; Nicotinamide Phosphoribosyltransferase; Pentosyltransferases; Sulfones; Xenograft Model Antitumor Assays | 2013 |
Effects of cavities at the nicotinamide binding site of liver alcohol dehydrogenase on structure, dynamics and catalysis.
Topics: Alcohol Dehydrogenase; Amino Acid Substitution; Animals; Benzaldehydes; Benzyl Alcohol; Benzyl Alcohols; Binding Sites; Catalysis; Crystallography, X-Ray; Horses; Kinetics; Liver; Models, Molecular; Mutagenesis, Site-Directed; NAD; Niacinamide; Protein Binding; Protein Conformation; Trifluoroethanol; Valine | 2014 |
New function for Escherichia coli xanthosine phophorylase (xapA): genetic and biochemical evidences on its participation in NAD(+) salvage from nicotinamide.
Topics: Culture Media; Escherichia coli; Escherichia coli Proteins; Gene Knockout Techniques; NAD; Niacinamide; Pentosyltransferases; Purine-Nucleoside Phosphorylase | 2014 |
Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3.
Topics: Adipose Tissue, Brown; Animals; Energy Metabolism; Forkhead Box Protein O1; Forkhead Transcription Factors; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondrial Myopathies; Muscle, Skeletal; NAD; Niacinamide; Pyridinium Compounds; Sirtuin 1; Unfolded Protein Response; Vitamin B Complex | 2014 |
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Topics: Acetyltransferases; Adipocytes; Adipose Tissue; Adipose Tissue, White; Animals; Diabetes Mellitus, Type 2; Diet; Energy Metabolism; Fatty Liver; Gene Knockdown Techniques; Glucose Intolerance; Glucose Transporter Type 4; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; NAD; Niacinamide; Nicotinamide N-Methyltransferase; Obesity; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; S-Adenosylmethionine; Sirtuin 1; Spermine; Thinness | 2014 |
YCL047C/POF1 is a novel nicotinamide mononucleotide adenylyltransferase (NMNAT) in Saccharomyces cerevisiae.
Topics: Amino Acid Sequence; Homeostasis; Molecular Sequence Data; NAD; Niacinamide; Nicotinamide-Nucleotide Adenylyltransferase; Pyridinium Compounds; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2014 |
Formation of [nicotinamide-²H₃]NAD⁺ from [²H₄]nicotinamide and [²H₄]nicotinic acid in human HepG2N cells and involvement of ²H/¹H exchange at the redox site of NAD⁺/NADH.
Topics: Carbon; Chromatography, Liquid; Coenzymes; Hep G2 Cells; Humans; Hydrogen; NAD; Niacinamide; Nicotinic Acids; Oxidation-Reduction; Tandem Mass Spectrometry | 2014 |
NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease.
Topics: Animals; Dietary Supplements; Disease Models, Animal; Electron Transport Complex IV; Energy Metabolism; Enzyme Activation; Gene Expression; Mice; Mice, Knockout; Mitochondria; Mitochondrial Diseases; Molecular Chaperones; NAD; Niacinamide; Oxidative Phosphorylation; Phenanthrenes; Phenotype; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Pyridinium Compounds; Sirtuin 1 | 2014 |
Spinal SIRT1 activation attenuates neuropathic pain in mice.
Topics: Animals; Down-Regulation; Hyperalgesia; Male; Mice; Mice, Inbred Strains; NAD; Neuralgia; Niacinamide; Resveratrol; Sirtuin 1; Spinal Cord; Stilbenes | 2014 |
Strategies for regeneration of nicotinamide coenzymes emphasizing self-sufficient closed-loop recycling systems.
Topics: 2-Propanol; Alcohol Dehydrogenase; Biocatalysis; Coenzymes; Formate Dehydrogenases; Glucose 1-Dehydrogenase; NAD; NADP; Niacinamide; Oxidation-Reduction | 2014 |
Up-regulation of nicotinamide phosphoribosyltransferase and increase of NAD+ levels by glucose restriction extend replicative lifespan of human fibroblast Hs68 cells.
Topics: Acrylamides; Benzamides; Cell Line; Cell Proliferation; Cell Survival; Cells, Cultured; Cellular Senescence; Cytokines; Dose-Response Relationship, Drug; Fibroblasts; Glucose; Humans; NAD; Naphthols; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Sirtuin 1; Up-Regulation | 2015 |
Quantification of protein copy number in yeast: the NAD+ metabolome.
Topics: Metabolome; NAD; Niacin; Niacinamide; Nicotinamidase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2 | 2014 |
Mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studies.
Topics: Humans; Kinetics; Ligands; Mitochondria; NAD; Niacinamide; Protein Binding; Sirtuin 3 | 2014 |
Alteration in substrate specificity of horse liver alcohol dehydrogenase by an acyclic nicotinamide analog of NAD(+).
Topics: 2-Propanol; Alcohol Dehydrogenase; Alcohols; Animals; Catalytic Domain; Chemistry Techniques, Synthetic; Deuterium; Enzyme Inhibitors; Horses; NAD; Niacinamide; Oligopeptides; Spectrophotometry, Ultraviolet; Substrate Specificity | 2014 |
Boosting NAD to spare hearing.
Topics: Animals; Female; Hearing Loss, Noise-Induced; Male; NAD; Niacinamide; Sirtuin 3 | 2014 |
Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss.
Topics: Animals; Female; Hearing Loss, Noise-Induced; Male; Mice; NAD; Niacinamide; Pyridinium Compounds; Sirtuin 3 | 2014 |
Reversing neurodegenerative hearing loss.
Topics: Animals; Disease Models, Animal; Hearing Loss; Humans; Mice; Mice, Knockout; NAD; Neurodegenerative Diseases; Niacinamide; Pyridinium Compounds; Sirtuin 3 | 2015 |
Abroma augusta L. (Malvaceae) leaf extract attenuates diabetes induced nephropathy and cardiomyopathy via inhibition of oxidative stress and inflammatory response.
Topics: Adenosine Triphosphate; Animals; Biomarkers; Blood Glucose; Body Weight; Cardiomyopathies; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; DNA Fragmentation; Glucose Tolerance Test; Inflammation; Kidney; Male; Malvaceae; Myocardium; NAD; Niacinamide; Organ Size; Oxidative Stress; Phytochemicals; Plant Extracts; Plant Leaves; Rats, Wistar | 2015 |
Pharmacological NAD-Boosting Strategies Improve Mitochondrial Homeostasis in Human Complex I-Mutant Fibroblasts.
Topics: Energy Metabolism; Fibroblasts; Homeostasis; Humans; Infant; Leukoencephalopathies; Membrane Potential, Mitochondrial; Mitochondria; Mutation; NAD; NADH Dehydrogenase; Niacinamide; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Pyridinium Compounds; Signal Transduction | 2015 |
Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation.
Topics: Acylation; Catalysis; Humans; Kinetics; NAD; Niacinamide; Protein Binding; Sirtuin 1; Sirtuin 2; Sirtuin 3; Sirtuins | 2015 |
APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells.
Topics: Acrylamides; Adenosine Triphosphate; Aged; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cell Survival; Chromosome Aberrations; Cyclosporine; Drug Resistance, Neoplasm; Drug Synergism; Endoplasmic Reticulum Stress; Female; Gene Expression; Humans; Immunoglobulin Heavy Chains; Leukemia; Male; Membrane Potential, Mitochondrial; Middle Aged; Mitochondria; Mutation; NAD; Neoplasm Staging; Niacin; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Primary Cell Culture; Prognosis; Tumor Cells, Cultured; Unfolded Protein Response | 2015 |
PARPs and ADP-Ribosylation: 50 Years … and Counting.
Topics: Adenosine Diphosphate Ribose; Biomedical Research; Biosynthetic Pathways; Forecasting; Humans; Interviews as Topic; Molecular Structure; NAD; Niacinamide; Nicotinamide Mononucleotide; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Protein Processing, Post-Translational; Time Factors | 2015 |
SnapShot: ADP-Ribosylation Signaling.
Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; Biosynthetic Pathways; Humans; Models, Chemical; Molecular Structure; NAD; Niacinamide; Poly (ADP-Ribose) Polymerase-1; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Signal Transduction | 2015 |
Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p.
Topics: Acetyl Coenzyme A; Acetylation; Biotin; Cell Respiration; Energy Metabolism; Histone Deacetylases; Homeostasis; Mass Spectrometry; Microscopy, Fluorescence; Mitochondria; Mitochondrial Proteins; NAD; Niacinamide; Organisms, Genetically Modified; Oxygen Consumption; Reactive Oxygen Species; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Starvation | 2015 |
A Nampt inhibitor FK866 mimics vitamin B3 deficiency by causing senescence of human fibroblastic Hs68 cells via attenuation of NAD(+)-SIRT1 signaling.
Topics: Acrylamides; AMP-Activated Protein Kinases; Cell Line; Cell Proliferation; Cellular Senescence; Cytokines; Enzyme Inhibitors; Fibroblasts; Glutathione; Humans; NAD; NADP; Niacin; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Signal Transduction; Sirtuin 1; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2015 |
Nicotinamide: a vitamin able to shift macrophage differentiation toward macrophages with restricted inflammatory features.
Topics: Cell Differentiation; Cells, Cultured; Eicosanoids; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inflammation; Macrophage Colony-Stimulating Factor; Macrophages; Monocytes; NAD; NF-kappa B; Niacinamide; Signal Transduction; Vitamin B Complex | 2015 |
Generation, Release, and Uptake of the NAD Precursor Nicotinic Acid Riboside by Human Cells.
Topics: 5'-Nucleotidase; Cytokines; HEK293 Cells; Hep G2 Cells; Humans; Kinetics; Magnetic Resonance Spectroscopy; Metabolic Networks and Pathways; NAD; Niacin; Niacinamide; Nicotinamide Phosphoribosyltransferase; Pentosyltransferases; Phosphorylation; Pyridinium Compounds; Recombinant Proteins; Ribonucleosides; Signal Transduction; Substrate Specificity | 2015 |
Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice.
Topics: Analysis of Variance; Animals; Area Under Curve; Biopsy, Needle; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Immunohistochemistry; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mitochondria; NAD; Niacinamide; Pyridinium Compounds; Random Allocation; Sensitivity and Specificity; Treatment Outcome; Unfolded Protein Response | 2016 |
Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model.
Topics: 5'-Nucleotidase; Acrylamides; Adenosine Triphosphate; Animals; Cell Line, Tumor; Cytokines; Female; GPI-Linked Proteins; Humans; Mice; Mice, Nude; NAD; Niacinamide; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Ovarian Neoplasms; Piperidines; Pyridinium Compounds; RNA Interference; RNA, Small Interfering | 2016 |
Therapeutic potential of nicotinamide adenine dinucleotide for nonalcoholic fatty liver disease.
Topics: Animals; Fatty Liver; Male; NAD; Niacinamide; Unfolded Protein Response | 2016 |
NO-Mediated [Ca2+]cyt Increases Depend on ADP-Ribosyl Cyclase Activity in Arabidopsis.
Topics: ADP-ribosyl Cyclase; Arabidopsis; Arabidopsis Proteins; Calcium; Cytosol; Guanine Nucleotides; NAD; Niacinamide; Nitric Oxide; Signal Transduction | 2016 |
PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection.
Topics: 3-Hydroxybutyric Acid; Acute Kidney Injury; Adipose Tissue; Amino Acids; Animals; Cytokines; Dinoprostone; Humans; Ischemia; Kidney; Male; Mice; Mice, Inbred C57BL; Mitochondria; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Signal Transduction; Stress, Physiological; Transcription Factors | 2016 |
Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson's disease.
Topics: Animals; Blotting, Western; Brain; Dietary Supplements; Disease Models, Animal; Dopaminergic Neurons; Drosophila; Drosophila Proteins; Genotype; Longevity; Male; Membrane Potential, Mitochondrial; Mitochondria; Mutagenesis; NAD; Niacinamide; Parkinson Disease; Poly(ADP-ribose) Polymerases; Ubiquitin-Protein Ligases | 2016 |
Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk.
Topics: Animals; Cattle; Commerce; Female; Food Microbiology; Food, Organic; Magnetic Resonance Spectroscopy; Milk; Milk Proteins; NAD; Niacin; Niacinamide; Provitamins; Pyridinium Compounds; Staphylococcus aureus; Tandem Mass Spectrometry; Vitamin B Complex | 2016 |
NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice.
Topics: Animals; Cellular Reprogramming; Cellular Senescence; Disease Models, Animal; Longevity; Melanocytes; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Mitochondria; Muscular Dystrophies; Myoblasts, Skeletal; NAD; Neural Stem Cells; Niacinamide; Oxidative Stress; Prohibitins; Pyridinium Compounds; Repressor Proteins; Unfolded Protein Response | 2016 |
Depletion of NAD pool contributes to impairment of endothelial progenitor cell mobilization in diabetes.
Topics: Animals; Chemokine CXCL12; Diabetes Mellitus, Type 2; Endothelial Progenitor Cells; Female; Hindlimb; Humans; Ischemia; Male; Mice; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Nitric Oxide Synthase Type III; Wound Healing | 2016 |
Nicotinamide cofactor ratios in engineered strains of Clostridium thermocellum and Thermoanaerobacterium saccharolyticum.
Topics: Biofuels; Biomass; Clostridium thermocellum; Ethanol; Fermentation; Metabolic Engineering; Metabolic Networks and Pathways; NAD; NADP; Niacinamide; Oxidation-Reduction; Thermoanaerobacterium | 2016 |
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism.
Topics: ADP-ribosyl Cyclase 1; Aging; Animals; Diet, High-Fat; Mammals; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NAD; NAD+ Nucleosidase; Niacinamide; Organ Specificity; Pyridinium Compounds; RNA, Messenger; Sirtuin 3 | 2016 |
Auxotrophic Actinobacillus pleurpneumoniae grows in multispecies biofilms without the need for nicotinamide-adenine dinucleotide (NAD) supplementation.
Topics: Acetylglucosamine; Actinobacillus Infections; Actinobacillus pleuropneumoniae; Animals; Biofilms; Bordetella bronchiseptica; Culture Media; Deoxyribonuclease I; Endopeptidase K; Escherichia coli; In Situ Hybridization, Fluorescence; Microscopy, Confocal; NAD; Niacinamide; Nicotinamide Mononucleotide; Pasteurella multocida; Pyridines; Pyridinium Compounds; Species Specificity; Staphylococcus aureus; Stem Cells; Streptococcus suis; Swine; Swine Diseases | 2016 |
Nicotinamide mononucleotide inhibits post-ischemic NAD(+) degradation and dramatically ameliorates brain damage following global cerebral ischemia.
Topics: Animals; Brain Injuries; Brain Ischemia; Cell Death; Disease Models, Animal; Hippocampus; Male; Mice, Inbred C57BL; NAD; Niacinamide; Nicotinamide Mononucleotide | 2016 |
The NAD(+) precursor nicotinamide riboside decreases exercise performance in rats.
Topics: Animals; Dietary Supplements; Male; Muscle, Skeletal; NAD; Niacinamide; Oxidation-Reduction; Phosphorylation; Physical Conditioning, Animal; Pyridinium Compounds; Rats; Rats, Wistar | 2016 |
Human serine racemase is allosterically modulated by NADH and reduced nicotinamide derivatives.
Topics: Adenosine Triphosphate; Allosteric Site; Binding Sites; Humans; Inhibitory Concentration 50; Kinetics; NAD; NADP; Niacinamide; Protein Binding; Protein Structure, Tertiary; Racemases and Epimerases; Receptors, N-Methyl-D-Aspartate; Serine | 2016 |
Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle.
Topics: Administration, Oral; Aging; Animals; Biological Availability; Energy Metabolism; Glucose; Homeostasis; Inflammation; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Muscle Strength; Muscle, Skeletal; NAD; Necrosis; Niacinamide; Nicotinamide Phosphoribosyltransferase; Organ Size; Physical Conditioning, Animal; Pyridinium Compounds; Transcription, Genetic | 2016 |
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans.
Topics: Administration, Oral; Animals; Biological Availability; Biomarkers; Humans; Leukocytes, Mononuclear; Liver; Male; Metabolome; Mice, Inbred C57BL; Middle Aged; NAD; Niacinamide; Pyridinium Compounds; Vitamins | 2016 |
β-Nicotinamide Mononucleotide, an Anti-Aging Candidate Compound, Is Retained in the Body for Longer than Nicotinamide in Rats.
Topics: Aging; Animals; Injections, Intraperitoneal; Longevity; Male; NAD; Niacinamide; Nicotinamide Mononucleotide; Rats; Rats, Wistar | 2016 |
NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells.
Topics: Animals; Hep G2 Cells; Hepatocytes; Humans; Injections, Intraperitoneal; Mammals; Mice, Knockout; NAD; Niacinamide; Nicotinamide Mononucleotide; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds | 2016 |
Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration.
Topics: Animals; Disease Models, Animal; Fluorescent Antibody Technique; Hepatectomy; Immunoblotting; Immunohistochemistry; Liver; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NAD; Niacinamide; Pyridinium Compounds; Random Allocation; Sensitivity and Specificity | 2017 |
Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism.
Topics: Cell Cycle; Cell Proliferation; Cells, Cultured; Cellular Senescence; Cluster Analysis; Fibroblasts; Homeostasis; Humans; Intracellular Space; Metabolome; Metabolomics; Models, Biological; NAD; Niacinamide; Oxidation-Reduction; Principal Component Analysis; Tryptophan | 2016 |
Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light.
Topics: Alcohol Oxidoreductases; Biocatalysis; Coenzymes; Halogenation; Hydrogen; Lactones; Light; NAD; NADP; Niacinamide; Oxidation-Reduction; Photons; Substrate Specificity | 2016 |
Simultaneous quantitation of nicotinamide riboside, nicotinamide mononucleotide and nicotinamide adenine dinucleotide in milk by a novel enzyme-coupled assay.
Topics: Animals; Cattle; Enzyme Assays; Equidae; Fluorometry; Food Analysis; Food Handling; Humans; Milk; Milk, Human; NAD; Niacinamide; Nicotinamide Mononucleotide; Pasteurization; Pyridinium Compounds | 2017 |
Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Eosinophils; Escape Reaction; Female; Hyperalgesia; Leukocyte Count; Locomotion; NAD; Neutrophils; Niacinamide; Nociception; Paclitaxel; Pain Measurement; Peripheral Nervous System Diseases; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Time Factors | 2017 |
NAD
Topics: Animals; Atrophy; Cell Line; Chick Embryo; Dioxins; Fatty Liver; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Receptors, Aryl Hydrocarbon; Sirtuins; Thymus Gland | 2017 |
Nicking Glaucoma with Nicotinamide?
Topics: Administration, Oral; Animals; Disease Models, Animal; Gene Expression; Genetic Therapy; Glaucoma; Humans; Intraocular Pressure; Mice; Mitochondria; NAD; Niacinamide; Retina; Vitamin B Complex | 2017 |
Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Caenorhabditis elegans; Disease Models, Animal; Homeostasis; Humans; Male; Memory; Mice; Mice, Transgenic; Mitochondria; Mitophagy; NAD; Niacinamide; Oxidative Phosphorylation; Protein Aggregation, Pathological; Protein Biosynthesis; Proteostasis; Pyridinium Compounds; Unfolded Protein Response | 2017 |
Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy.
Topics: Acrylamides; AMP-Activated Protein Kinases; Animals; Cardiomyopathy, Dilated; Citric Acid; Cytokines; Dietary Supplements; Disease Models, Animal; Gene Expression Profiling; Heart Failure; Metabolome; Mice; Mice, Transgenic; Myocytes, Cardiac; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Phosphotransferases (Alcohol Group Acceptor); Piperidines; PPAR alpha; Pyridinium Compounds; Rats; Serum Response Factor | 2018 |
Characterization of CobB kinetics and inhibition by nicotinamide.
Topics: Acetates; Acetyl Coenzyme A; Acetylation; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Histones; Kinetics; Lysine; NAD; Niacinamide; Phenotype; Plasmids; Protein Folding; Sirtuins; Substrate Specificity | 2017 |
Synthesis of β-Nicotinamide Riboside Using an Efficient Two-Step Methodology.
Topics: Animals; Chromatography, High Pressure Liquid; NAD; Niacinamide; Nicotinic Acids; Proton Magnetic Resonance Spectroscopy; Pyridinium Compounds; Stereoisomerism | 2017 |
Identification of the Nicotinamide Salvage Pathway as a New Toxification Route for Antimetabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Glycolysis; Humans; Melanoma; Mice, Nude; Models, Molecular; NAD; Neuroblastoma; Niacinamide; Nicotinamide Phosphoribosyltransferase; Phenylurea Compounds | 2018 |
Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.
Topics: Animals; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Fatty Liver; Healthy Aging; Inflammation; Liver; Longevity; Mice, Inbred C57BL; NAD; Niacinamide; Oxidative Stress; Sirtuin 1 | 2018 |
Hyperthermophilic Archaeon Thermococcus kodakarensis Utilizes a Four-Step Pathway for NAD
Topics: Deamination; Hot Temperature; NAD; Niacinamide; Nicotinamidase; Nicotinamide Mononucleotide; Nicotinic Acids; Nucleotidyltransferases; Pentosyltransferases; Recombinant Proteins; Substrate Specificity; Thermococcus | 2018 |
Overexpression of NRK1 ameliorates diet- and age-induced hepatic steatosis and insulin resistance.
Topics: Aging; Animals; Diet, High-Fat; Fatty Liver; HEK293 Cells; Humans; Insulin Resistance; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; NAD; Niacinamide; NIH 3T3 Cells; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds; Triglycerides | 2018 |
Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway.
Topics: Animals; Chemical and Drug Induced Liver Injury; Ethanol; Gene Expression Regulation; Hep G2 Cells; Humans; Lipid Metabolism; Mice; Mitochondria; NAD; Niacinamide; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pyridinium Compounds; RNA, Long Noncoding | 2018 |
Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.
Topics: Animals; Female; HCT116 Cells; Hep G2 Cells; Humans; Intestine, Small; Liver; Mice; Mice, Inbred C57BL; Muscle, Skeletal; NAD; Niacinamide; Poly(ADP-ribose) Polymerases; Sirtuins; Spleen; Tryptophan | 2018 |
Raising NAD in Heart Failure: Time to Translate?
Topics: Animals; Cardiomyopathy, Dilated; Heart Failure; Mice; NAD; Niacinamide; Pyridinium Compounds | 2018 |
NNMT activation can contribute to the development of fatty liver disease by modulating the NAD
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Fatty Acids; Fatty Liver; Lipoproteins, VLDL; Liver; Liver Cirrhosis; Methionine; Mice, Inbred C57BL; Mice, Transgenic; NAD; Niacinamide; Nicotinamide N-Methyltransferase | 2018 |
The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease.
Topics: Animals; Autophagy; Disease Models, Animal; Dopaminergic Neurons; Drosophila melanogaster; Endoplasmic Reticulum Stress; Glucosylceramidase; Humans; Induced Pluripotent Stem Cells; Mitochondria; Mitochondrial Dynamics; Motor Activity; NAD; Neurons; Niacinamide; Parkinson Disease; Pyridinium Compounds; Unfolded Protein Response | 2018 |
Nicotinamide adenine dinucleotide is transported into mammalian mitochondria.
Topics: Animals; Biological Transport; Cell Line; HEK293 Cells; HL-60 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Mitochondria, Muscle; Myoblasts; NAD; Niacinamide; Nicotinamide Mononucleotide; Pyridinium Compounds | 2018 |
NAD
Topics: Animals; Apoptosis; Bacterial Toxins; Biocatalysis; Cytoprotection; Humans; Jurkat Cells; Macrophages; Mice, Inbred C57BL; Mitochondria; Models, Biological; Mycobacterium tuberculosis; NAD; NAD+ Nucleosidase; Necrosis; Niacinamide; Protein Kinases; Receptor-Interacting Protein Serine-Threonine Kinases; THP-1 Cells; Tumor Necrosis Factor-alpha | 2018 |
Nicotinamide riboside supplementation dysregulates redox and energy metabolism in rats: Implications for exercise performance.
Topics: Animals; Catalase; Energy Metabolism; Erythrocytes; Glutathione Peroxidase; Glutathione Reductase; Male; NAD; Niacinamide; Oxidation-Reduction; Physical Conditioning, Animal; Pyridinium Compounds; Rats; Rats, Wistar | 2018 |
Rescue of biosynthesis of nicotinamide adenine dinucleotide protects the heart in cardiomyopathy caused by lamin A/C gene mutation.
Topics: Animals; Cardiomyopathies; Disease Models, Animal; Heart; Heart Failure; Heart Ventricles; Humans; Lamin Type A; Mice; Mutation; NAD; Niacinamide; Poly (ADP-Ribose) Polymerase-1; Poly ADP Ribosylation; Ventricular Dysfunction, Left | 2018 |
Kinetic Mechanism of Nicotinamide N-Methyltransferase.
Topics: Humans; Kinetics; Methylation; NAD; Niacinamide; Nicotinamide N-Methyltransferase; S-Adenosylmethionine | 2018 |
Pharmacological bypass of NAD
Topics: Acrylamides; Animals; Antineoplastic Agents, Phytogenic; Drug Combinations; Francisella tularensis; Ganglia, Spinal; NAD; Nerve Degeneration; Neurons; Niacinamide; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Piperidines; Pyridinium Compounds; Vincristine | 2018 |
Nicotinamide-Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs.
Topics: Adenine; Molecular Conformation; NAD; Niacinamide; RNA Caps | 2018 |
Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells.
Topics: Actomyosin; Casein Kinase I; Cell Differentiation; Cell Survival; Human Embryonic Stem Cells; Humans; NAD; Niacinamide; Pluripotent Stem Cells; Protein Kinase Inhibitors; rho-Associated Kinases | 2018 |
NAD Metabolome Analysis in Human Cells Using ¹H NMR Spectroscopy.
Topics: Blood Platelets; Cell Culture Techniques; Erythrocytes; HEK293 Cells; Humans; Metabolic Networks and Pathways; Metabolomics; NAD; NADP; Niacin; Niacinamide; Proton Magnetic Resonance Spectroscopy | 2018 |
Metabolism of 4-pyridone-3-carboxamide-1β-d-ribonucleoside (4PYR) in primary murine brain microvascular endothelial cells (mBMECs).
Topics: Adenine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Brain; Chromatography, High Pressure Liquid; Endothelial Cells; Energy Metabolism; Humans; Male; Microvessels; NAD; Niacinamide; Nucleosides; Pyridones | 2018 |
Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring.
Topics: Animals; Female; Lactation; Liver; Maternal Exposure; Mice; NAD; Neurogenesis; Niacinamide; Postpartum Period; Pregnancy; Prenatal Exposure Delayed Effects; Pyridinium Compounds; Weight Loss | 2019 |
Nicotinamide as a chemopreventive therapy of skin cancers. Too much of good thing?
Topics: Chemoprevention; Humans; NAD; Niacinamide; Signal Transduction; Skin Neoplasms | 2019 |
Nicotinamide Metabolism Modulates the Proliferation/Differentiation Balance and Senescence of Human Primary Keratinocytes.
Topics: 3T3 Cells; Acrylamides; Adult; Animals; Cell Differentiation; Cell Proliferation; Cellular Senescence; Cytokines; Female; Healthy Volunteers; Humans; Keratinocytes; Mice; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Primary Cell Culture; Skin; Skin Aging; Stem Cells | 2019 |
NR Supplementation During Lactation: Benefiting Mother and Child.
Topics: Adolescent; Adult Children; Child; Dietary Supplements; Female; Humans; Lactation; Mothers; NAD; Neurogenesis; Niacinamide; Postpartum Period; Pyridinium Compounds; Weight Loss | 2019 |
Quercetin based derivatives as sirtuin inhibitors.
Topics: Binding Sites; Humans; Molecular Docking Simulation; NAD; Niacinamide; Polyphenols; Quercetin; Sirtuins | 2019 |
The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance.
Topics: Animals; Cells, Cultured; Hematopoiesis; Hematopoietic Stem Cells; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NAD; Niacinamide; Pyridinium Compounds | 2019 |
DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD
Topics: Animals; Atrial Fibrillation; Benzimidazoles; Cells, Cultured; DNA Damage; Drosophila melanogaster; Enzyme Activation; Heart Atria; Humans; Larva; Mice; Models, Cardiovascular; Myocardial Contraction; Myocytes, Cardiac; NAD; Niacinamide; Oxidative Stress; Pacemaker, Artificial; Phthalazines; Piperazines; Poly (ADP-Ribose) Polymerase-1; Pupa; Rats; Rats, Wistar | 2019 |
NAD
Topics: Adult Stem Cells; Aging; Animals; Carbazoles; Cell Proliferation; Cells, Cultured; Dextran Sulfate; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; NAD; Niacinamide; Pyridinium Compounds; Rejuvenation; Sirolimus | 2019 |
Escherichia coli Strain Designed for Characterizing in Vivo Functions of Nicotinamide Adenine Dinucleotide Analogues.
Topics: Coenzymes; Cytosine; Escherichia coli; Escherichia coli Proteins; Hypoxanthines; Molecular Structure; Mutation; NAD; Niacinamide; Phosphoric Diester Hydrolases; Pyrophosphatases | 2019 |
NAD metabolites interfere with proliferation and functional properties of THP-1 cells.
Topics: Antigens, Differentiation; Cell Cycle; Cell Proliferation; Chemokines; Humans; Lipopolysaccharides; Monocytes; NAD; Niacinamide; Poly (ADP-Ribose) Polymerase-1; Pyridinium Compounds; Reactive Oxygen Species; Sirtuin 1; THP-1 Cells; Tumor Necrosis Factor-alpha | 2019 |
Nicotinamide riboside, an NAD+ precursor, attenuates the development of liver fibrosis in a diet-induced mouse model of liver fibrosis.
Topics: Animals; Body Weight; Collagen; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Energy Metabolism; Hepatic Stellate Cells; Humans; Liver; Mice; Mice, Inbred C57BL; Muscle, Skeletal; NAD; Niacinamide; Non-alcoholic Fatty Liver Disease; Pyridinium Compounds | 2019 |
Quartz Crystal Microbalance Detection of Poly(ADP-ribose) Polymerase-1 Based on Gold Nanorods Signal Amplification.
Topics: Adenosine Diphosphate Ribose; Biomarkers, Tumor; Cell Line, Tumor; Cetrimonium; Female; Gold; Humans; Limit of Detection; NAD; Nanotubes; Neoplasm Proteins; Niacinamide; Ovarian Neoplasms; Poly (ADP-Ribose) Polymerase-1; Poly Adenosine Diphosphate Ribose; Quartz Crystal Microbalance Techniques; Static Electricity | 2019 |
Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity.
Topics: Animals; Antioxidants; Autophagy; Cardiotoxicity; Cells, Cultured; Cytoprotection; Disease Models, Animal; Doxorubicin; Heart Diseases; Hydrogen-Ion Concentration; Lysosomes; Male; Mice, Inbred C57BL; Mice, Transgenic; Myocytes, Cardiac; NAD; Niacinamide; Oxidative Stress; Pyridinium Compounds; Sirtuin 1 | 2019 |
NAD
Topics: Aerobiosis; Animals; Cell Respiration; Male; Mice; Mice, Inbred C57BL; Mitochondria; Muscle, Skeletal; NAD; Niacinamide; Pyridinium Compounds | 2020 |
Genetic evidence for
Topics: Culture Media; Fungal Proteins; Host-Pathogen Interactions; Magnaporthe; Mutation; NAD; Niacin; Niacinamide; Oryza; Pentosyltransferases; Plant Diseases; Plant Leaves | 2019 |
Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage.
Topics: Animals; Blood Glucose; Diet, High-Fat; Disease Models, Animal; DNA Damage; Gene Knockout Techniques; Genetic Predisposition to Disease; Glucose Intolerance; Hepatocytes; Insulin Resistance; Lipid Metabolism; Liver; Liver Diseases; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD; Niacinamide; Phosphotransferases (Alcohol Group Acceptor); Protective Agents; Pyridinium Compounds | 2019 |
The senotherapeutic nicotinamide riboside raises platelet nicotinamide adenine dinucleotide levels but cannot prevent storage lesion.
Topics: Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Blood Platelets; Blood Preservation; Caspase 3; Cytochromes c; Humans; NAD; Niacinamide; Platelet Aggregation; Pyridinium Compounds | 2020 |
Increased fatty acid oxidation and mitochondrial proliferation in liver are associated with increased plasma kynurenine metabolites and nicotinamide levels in normolipidemic and carnitine-depleted rats.
Topics: Animals; Carnitine; Cell Proliferation; Kynurenine; Lipid Metabolism; Liver; Male; Metabolic Networks and Pathways; Methylhydrazines; Mitochondria; NAD; Niacinamide; Oxidation-Reduction; Peroxisomes; Rats; Tryptophan | 2020 |
Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Calcium Chloride; Cells, Cultured; Dilatation, Pathologic; Disease Models, Animal; Male; Mice, Inbred C57BL; Mice, Knockout; NAD; Niacin; Niacinamide; Receptors, G-Protein-Coupled; Receptors, LDL; Signal Transduction; Sirtuin 1 | 2020 |
A reduced form of nicotinamide riboside defines a new path for NAD
Topics: Animals; Cell Line; Male; Mice; NAD; Niacinamide; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds; Rats | 2019 |
Design, Synthesis and Molecular Modeling Study of Conjugates of ADP and Morpholino Nucleosides as A Novel Class of Inhibitors of PARP-1, PARP-2 and PARP-3.
Topics: Adenosine Diphosphate; Binding Sites; Humans; Morpholinos; NAD; Niacinamide; Nucleosides; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases | 2019 |
Targeting NAD
Topics: Acrylamides; Adenosine; Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase 1; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cytokines; Drug Synergism; Humans; Membrane Glycoproteins; Multiple Myeloma; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Regulatory; Tumor Escape; Warburg Effect, Oncologic | 2020 |
Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway.
Topics: Administration, Oral; Amides; Animals; Biosynthetic Pathways; Cell Line, Tumor; Cytokines; Energy Metabolism; Female; Gastrointestinal Microbiome; Humans; Male; Mammals; Metabolome; Mice, Inbred C57BL; Mycoplasma; NAD; Niacinamide; Nicotinamidase; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Pyridinium Compounds | 2020 |
A Noninvasive Urine Metabolome Panel as Potential Biomarkers for Diagnosis of T Cell-Mediated Renal Transplant Rejection.
Topics: Acute Disease; Adenosine Diphosphate; Adult; Biomarkers; Cholesterol Esters; Cross-Sectional Studies; Female; gamma-Aminobutyric Acid; Graft Rejection; Graft Survival; Hippurates; Humans; Kidney Transplantation; Male; Metabolome; Middle Aged; NAD; Niacin; Niacinamide; Proline; Renal Insufficiency, Chronic; ROC Curve; Spermidine; T-Lymphocytes | 2020 |
Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration.
Topics: Animals; Apoptosis; Cerebral Cortex; DNA Damage; DNA Topoisomerases, Type I; Genomic Instability; Hippocampus; Inflammation; Mice; Mice, Knockout; Mortality, Premature; Motor Activity; Mutation; NAD; Neurodegenerative Diseases; Neurons; Niacinamide; Poly (ADP-Ribose) Polymerase-1; Pyridinium Compounds | 2020 |
Targeting sirtuin activity with nicotinamide riboside reduces neuroinflammation in a GWI mouse model.
Topics: Aged; Animals; Anti-Inflammatory Agents; Astrocytes; Behavior, Animal; Brain; Case-Control Studies; Disease Models, Animal; Energy Metabolism; Fatigue; Female; Gulf War; Humans; Male; Mice, Inbred C57BL; Middle Aged; Mitochondria; NAD; Niacinamide; Organelle Biogenesis; Oxidative Stress; Persian Gulf Syndrome; Pilot Projects; Pyridinium Compounds; Sirtuin 1; Veterans Health | 2020 |
Biomimetic asymmetric reduction of benzoxazinones and quinoxalinones using ureas as transfer catalysts.
Topics: Benzoxazines; Biomimetic Materials; Catalysis; Cell Cycle Proteins; Coordination Complexes; Hydrogen Bonding; Models, Chemical; Molecular Conformation; NAD; Niacinamide; Oxidation-Reduction; Quinoxalines; Ruthenium; Substrate Specificity; Transcription Factors; Urea | 2020 |
Increasing ovarian NAD
Topics: Aging; Animals; Energy Metabolism; Female; Mice; Mitochondria; NAD; Niacinamide; Reactive Oxygen Species | 2020 |
NRH salvage and conversion to NAD
Topics: Adenosine Kinase; Animals; Cells, Cultured; Mice; NAD; Niacinamide; Phosphorylation | 2020 |
A decrease in NAMPT activity impairs basal PARP-1 activity in cytidine deaminase deficient-cells, independently of NAD
Topics: Cytidine Deaminase; Cytokines; HeLa Cells; Humans; Mutation; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Poly (ADP-Ribose) Polymerase-1 | 2020 |
Identification of the first noncompetitive SARM1 inhibitors.
Topics: Amino Acid Motifs; Amino Acid Sequence; Armadillo Domain Proteins; Axons; Berberine; Binding Sites; Catalysis; Chlorides; Cytoskeletal Proteins; Gene Knockdown Techniques; High-Throughput Screening Assays; Humans; Hydrolases; Mutagenesis; NAD; Niacinamide; Protein Binding; Wallerian Degeneration; Zinc Compounds | 2020 |
Systemic Treatment With Nicotinamide Riboside Is Protective in a Mouse Model of Light-Induced Retinal Degeneration.
Topics: Animals; Disease Models, Animal; Electroretinography; Fluorescent Antibody Technique; Injections, Intraperitoneal; Light; Male; Mice; Mice, Inbred BALB C; NAD; Niacinamide; Photoreceptor Cells, Vertebrate; Pyridinium Compounds; Retina; Retinal Degeneration; Tomography, Optical Coherence | 2020 |
Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1-FOXO1/3-PINK1-Parkin-mediated mitophagy.
Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Peptides; Brain-Derived Neurotrophic Factor; Disease Progression; Exercise; Forkhead Box Protein O1; Humans; Mitochondria; Mitochondrial Diseases; Mitophagy; NAD; Niacinamide; Nicotinamide Mononucleotide; Protein Kinases; Pyridinium Compounds; Reactive Oxygen Species; Sirtuin 1; Ubiquitin-Protein Ligases | 2021 |
Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.
Topics: ADP-ribosyl Cyclase 1; Animals; Brain; Cell Line; Cellular Senescence; Dyskeratosis Congenita; Female; Fibroblasts; Homeostasis; Humans; Membrane Glycoproteins; Mice; Mice, Knockout; Mitochondria; NAD; Niacinamide; Phenotype; Poly (ADP-Ribose) Polymerase-1; Pyridinium Compounds; Telomerase; Telomere | 2020 |
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity.
Topics: A549 Cells; Adenosine Diphosphate Ribose; ADP-Ribosylation; Adult; Animals; Cell Line, Tumor; COVID-19; Female; Ferrets; Humans; Immunity, Innate; Male; Metabolome; Mice; Mice, Inbred C57BL; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Pyridinium Compounds; SARS-CoV-2 | 2020 |
A second riboswitch class for the enzyme cofactor NAD
Topics: Bacterial Proteins; Base Sequence; Binding Sites; Carrier Proteins; Coenzymes; Computational Biology; Corynebacterium glutamicum; Haemophilus influenzae; Lactobacillus acidophilus; NAD; Niacinamide; Nucleic Acid Conformation; Protein Binding; Pyridinium Compounds; Riboswitch; Shewanella; Streptococcus | 2021 |
Complementary NAD
Topics: ADP-ribosyl Cyclase 1; Animals; Dystrophin; Enzyme Inhibitors; Male; Membrane Glycoproteins; Metabolome; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle Contraction; Muscle, Skeletal; Muscular Dystrophy, Duchenne; NAD; Niacinamide; Pyridinium Compounds | 2020 |
The Auxiliary NADH Dehydrogenase Plays a Crucial Role in Redox Homeostasis of Nicotinamide Cofactors in the Absence of the Periplasmic Oxidation System in Gluconobacter oxydans NBRC3293.
Topics: Gluconobacter oxydans; Homeostasis; NAD; NADH Dehydrogenase; NADP; Niacinamide; Oxidation-Reduction; Periplasm | 2021 |
Mechanisms to reduce the cytotoxicity of pharmacological nicotinamide concentrations in the pathogenic fungus Candida albicans.
Topics: Candida albicans; Candidiasis; Cell Proliferation; Cell Survival; Fungal Proteins; Histone Deacetylases; Histones; Humans; Lysine; NAD; Niacinamide; Saccharomyces cerevisiae Proteins; Sirtuins | 2021 |
Nicotinamide Riboside and Pterostilbene Cooperatively Delay Motor Neuron Failure in ALS SOD1
Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Apoptosis; Cytokines; Female; Male; Metabolome; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Motor Activity; Motor Neurons; Mutation; NAD; Nerve Degeneration; NF-E2-Related Factor 2; Niacinamide; Oxidation-Reduction; Pyridinium Compounds; Reactive Oxygen Species; Sirtuin 1; Sirtuin 3; Spinal Cord; Stilbenes; Superoxide Dismutase-1; Survival Analysis | 2021 |
A vitaminic boost to rock the aortic wall.
Topics: Aorta; Aortic Aneurysm, Abdominal; Humans; NAD; Niacin; Niacinamide | 2020 |
Metabolic design for selective production of nicotinamide mononucleotide from glucose and nicotinamide.
Topics: Biosynthetic Pathways; Escherichia coli; Glucose; NAD; Niacinamide; Nicotinamide Mononucleotide | 2021 |
Bacteria boost host NAD metabolism.
Topics: Bacteria; Dietary Supplements; NAD; Niacinamide | 2020 |
Nicotinamide Attenuates the Progression of Renal Failure in a Mouse Model of Adenine-Induced Chronic Kidney Disease.
Topics: Adenine; Animals; Citric Acid Cycle; Disease Models, Animal; Disease Progression; Energy Metabolism; Glycolysis; Kidney; Male; Metabolic Networks and Pathways; Metabolome; Mice; Mice, Inbred C57BL; NAD; Niacinamide; Renal Insufficiency; Renal Insufficiency, Chronic | 2021 |
Nicotinamide riboside supplementation does not alter whole-body or skeletal muscle metabolic responses to a single bout of endurance exercise.
Topics: Dietary Supplements; Exercise; Male; Muscle, Skeletal; NAD; Niacinamide; Pyridinium Compounds | 2021 |
The Biochemical Pathways of Nicotinamide-Derived Pyridones.
Topics: Autophagy; Cell Line, Tumor; HEK293 Cells; Humans; NAD; Neoplasms; Niacinamide; Pyridones | 2021 |
Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells.
Topics: Aging; Cytosol; Equilibrative Nucleoside Transport Proteins; HEK293 Cells; Humans; Magnetic Resonance Spectroscopy; Membrane Transport Proteins; Metabolomics; NAD; Niacinamide; Nicotinamide Mononucleotide; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds; Recombinant Proteins; Ribonucleosides | 2021 |
Imeglimin amplifies glucose-stimulated insulin release from diabetic islets via a distinct mechanism of action.
Topics: Adenosine Triphosphate; Animals; Calcium; Cyclic ADP-Ribose; Cytokines; Diabetes Mellitus, Type 2; Glucose; Insulin Secretion; Islets of Langerhans; Male; Models, Biological; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Rats, Wistar; Ryanodine Receptor Calcium Release Channel; Sulfonylurea Compounds; Triazines | 2021 |
NAD
Topics: Animals; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Case-Control Studies; Cell Line, Tumor; Dietary Supplements; Disease Models, Animal; Female; Fibroblasts; Humans; Male; Membrane Proteins; Mice; Mice, Knockout; Mitochondria; Mitophagy; NAD; Neurons; Niacinamide; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Senescence-Associated Secretory Phenotype; Signal Transduction; Transfection; Treatment Outcome | 2021 |
NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and Required for Cardiac Function and NAD Levels during Aging.
Topics: Aging; Animals; Cardiomegaly; Cardiomyopathy, Dilated; Cytosol; Disease Models, Animal; Electrocardiography; Gene Expression Regulation; Humans; Intracellular Signaling Peptides and Proteins; Laminin; Mice, Inbred C57BL; Mice, Knockout; NAD; Niacinamide; Phosphotransferases (Alcohol Group Acceptor); Up-Regulation; Ventricular Remodeling | 2021 |
Design of artificial metalloenzymes for the reduction of nicotinamide cofactors.
Topics: Alcohol Dehydrogenase; Bacterial Proteins; Catalytic Domain; Coordination Complexes; Molecular Docking Simulation; Mutation; NAD; NADP; Niacinamide; Oxidation-Reduction; Protein Binding; Rhodium; Thermoanaerobacter | 2021 |
Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD
Topics: ADP-ribosyl Cyclase 1; Animals; Apigenin; Astrocytes; Chemokines; Cytokines; Gene Deletion; Hippocampus; Inflammation; Injections, Intraventricular; Lipopolysaccharides; Macrophage Activation; Male; Membrane Glycoproteins; Mice; Mice, Inbred ICR; Mice, Knockout; Microglia; NAD; Nerve Degeneration; NF-kappa B; Niacinamide; Pyridinium Compounds | 2021 |
NAD
Topics: Acetylation; Acyl-CoA Dehydrogenase; Animals; Disease Models, Animal; Down-Regulation; Fatty Acids; Heart Failure, Diastolic; Humans; Ketone Oxidoreductases; Male; Mice; Mice, Inbred C57BL; Mitochondria, Heart; Mitochondrial Myopathies; NAD; Niacinamide; Oxidation-Reduction; Oxygen Consumption; Pyridinium Compounds; Sirtuin 3 | 2021 |
Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells.
Topics: Age Factors; Aging; Animals; Bone Marrow Cells; Cells, Cultured; Gene Expression Profiling; Gene Expression Regulation; Hematopoietic Stem Cells; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Models, Biological; NAD; Niacinamide; Oxidative Phosphorylation; Pyridinium Compounds | 2021 |
Effect of NAD+ boosting on kidney ischemia-reperfusion injury.
Topics: Acute Kidney Injury; Animals; Autophagy; Disease Progression; Fibrosis; Glucuronidase; Kidney; Klotho Proteins; Male; Mitochondria; NAD; Niacinamide; Protective Agents; Pyridinium Compounds; Random Allocation; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Reperfusion Injury; Signal Transduction; Sirtuin 1; Treatment Outcome | 2021 |
Parp mutations protect from mitochondrial toxicity in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Behavior, Animal; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Humans; Metabolome; Metabolomics; Mitochondria; Motor Activity; Mutation; NAD; Nerve Degeneration; Neurons; Niacinamide; Poly (ADP-Ribose) Polymerase-1; Polymorphism, Single Nucleotide | 2021 |
Acidic pH irreversibly activates the signaling enzyme SARM1.
Topics: Acids; Armadillo Domain Proteins; Biocatalysis; Cytoskeletal Proteins; Disulfiram; Enzyme Activation; Enzyme Inhibitors; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mutation; NAD; Niacinamide; Protein Domains | 2021 |
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the nicotinamide adenine dinucleotide (NAD) salvage pathway, to target glioma heterogeneity through mitochondrial oxidative stress.
Topics: Animals; Cell Line, Tumor; Cytokines; Glioma; Humans; Mice; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Oxidative Stress | 2022 |
Metabolic engineering of Escherichia coli for biosynthesis of β-nicotinamide mononucleotide from nicotinamide.
Topics: Escherichia coli; Metabolic Engineering; NAD; Niacinamide; Nicotinamide Mononucleotide | 2021 |
NAD+ metabolism and cardiometabolic health: the human evidence.
Topics: Cardiovascular Diseases; Humans; NAD; Niacinamide | 2021 |
The female mouse is resistant to mild vitamin B
Topics: Adipose Tissue, White; Animals; Female; Liver; Male; Mice; Mice, Inbred C57BL; NAD; Niacinamide; Sex Factors; Vitamin B Deficiency; Vitamins | 2022 |
Instability in NAD
Topics: Animals; DNA Damage; DNA Repair; DNA, Mitochondrial; Heart; Heart Diseases; HeLa Cells; Humans; Mice; Mitochondria; Myocardium; NAD; Niacinamide; Pyridinium Compounds; Sirtuins | 2021 |
Enzymatic and Chemical Syntheses of Vacor Analogs of Nicotinamide Riboside, NMN and NAD.
Topics: ADP-ribosyl Cyclase; Animals; Antineoplastic Agents; Aplysia; Cell Proliferation; HEK293 Cells; Humans; NAD; Niacinamide; Phenylurea Compounds; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds | 2021 |
NAD
Topics: Aging; Animals; Caloric Restriction; Mice; NAD; Niacinamide | 2021 |
Biosynthesis of a Therapeutically Important Nicotinamide Mononucleotide through a Phosphoribosyl Pyrophosphate Synthetase 1 and 2 Engineered Strain of
Topics: Biosynthetic Pathways; Escherichia coli; Glucose; Metabolic Engineering; NAD; Niacinamide; Nicotinamide Mononucleotide; Nucleotides; Ribose-Phosphate Pyrophosphokinase | 2021 |
β-NAD as a building block in natural product biosynthesis.
Topics: Biological Products; Catalysis; NAD; Niacinamide; Signal Transduction | 2021 |
Targeting nicotinamide adenosine dinucleotide (NAD) in diffuse gliomas.
Topics: Adenosine; Glioma; Humans; NAD; Niacinamide | 2022 |
Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes.
Topics: Clinical Studies as Topic; Humans; Inosine; Interferon-beta; Lipopolysaccharides; Lupus Erythematosus, Systemic; Monocytes; NAD; Niacinamide; Toll-Like Receptor 4 | 2022 |
Engineering Formaldehyde Dehydrogenase from Pseudomonas putida to Favor Nicotinamide Cytosine Dinucleotide.
Topics: Aldehyde Oxidoreductases; Cytosine; Formaldehyde; Molecular Docking Simulation; NAD; Niacinamide; Pseudomonas putida | 2022 |
Nicotinamide Adenine Dinucleotide in the Development and Treatment of Cardiac Remodeling and Aging.
Topics: Aging; Animals; Antioxidants; Heart; Humans; Mice; NAD; Niacinamide; Ventricular Remodeling | 2022 |
Dihydronicotinamide Riboside Is a Potent NAD
Topics: Cytokines; Glycosides; Macrophages; NAD; Niacinamide; Phenotype | 2022 |
Gut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia.
Topics: Cell Line, Tumor; Cytokines; Gastrointestinal Microbiome; Humans; Leukemia; NAD; Neoplasms; Niacinamide; Nicotinamide Phosphoribosyltransferase | 2022 |
Nicotinamide riboside relieves the severity of experimental necrotizing enterocolitis by regulating endothelial function via eNOS deacetylation.
Topics: Animals; Disease Models, Animal; Endothelial Cells; Enterocolitis, Necrotizing; Mice; Microcirculation; NAD; Niacinamide; Nitric Oxide Synthase Type III; Pyridinium Compounds; Sirtuin 1; Tumor Necrosis Factor-alpha | 2022 |
The significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease.
Topics: Animals; Female; Fibrosis; Humans; Male; Methionine; Mice; NAD; Niacinamide; Nicotinamide N-Methyltransferase; Renal Insufficiency, Chronic; Ureteral Obstruction | 2022 |
Engineering Isopropanol Dehydrogenase for Efficient Regeneration of Nicotinamide Cofactors.
Topics: 2-Propanol; Formate Dehydrogenases; NAD; NADP; Niacinamide; Regeneration | 2022 |
Constructing a multienzyme cascade redox-neutral system for the synthesis of halogenated indoles.
Topics: Alcohol Dehydrogenase; Flavins; Indoles; NAD; Niacinamide; Oxidation-Reduction | 2022 |
Outpacing conventional nicotinamide hydrogenation catalysis by a strongly communicating heterodinuclear photocatalyst.
Topics: Catalysis; Hydrogenation; Ligands; NAD; Niacinamide; Oxidation-Reduction | 2022 |
Acute Treatment with Nicotinamide Riboside Chloride Reduces Hippocampal Damage and Preserves the Cognitive Function of Mice with Ischemic Injury.
Topics: Animals; Chlorides; Cognition; Hippocampus; Infarction, Middle Cerebral Artery; Mice; NAD; Niacinamide; Pyridinium Compounds | 2022 |
NAD-catabolizing ectoenzymes of Schistosoma mansoni.
Topics: Adenosine Diphosphate Ribose; Adenosine Monophosphate; Animals; NAD; Niacinamide; Schistosoma mansoni | 2022 |
Nicotinamide reprograms adipose cellular metabolism and increases mitochondrial biogenesis to ameliorate obesity.
Topics: Adipose Tissue; Animals; Glucose; Mice; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Obesity; Organelle Biogenesis; Proteomics | 2022 |
The 3D-structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP
Topics: Anti-Bacterial Agents; Escherichia coli; Escherichia coli Proteins; Hydroquinones; Hydroxylamines; Kinetics; NAD; NADP; Niacinamide; Nitroreductases; Phosphates; Prodrugs; Quinones | 2022 |
A reduced form of nicotinamide riboside protects the cochlea against aminoglycoside-induced ototoxicity by SIRT1 activation.
Topics: 14-3-3 Proteins; Aminoglycosides; Animals; Anti-Bacterial Agents; Cochlea; Hearing Loss; Kanamycin; Mice; NAD; Niacinamide; Ototoxicity; Pyridinium Compounds; Reactive Oxygen Species; Resveratrol; Sirtuin 1 | 2022 |
Nicotinamide Riboside Supplementation to Suckling Male Mice Improves Lipid and Energy Metabolism in Skeletal Muscle and Liver in Adulthood.
Topics: Animals; Diet, High-Fat; Dietary Supplements; Energy Metabolism; Lipid Metabolism; Lipids; Liver; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; NAD; Niacinamide; Pyridinium Compounds; Triglycerides | 2022 |
Functional and ligand binding studies of NAD(P)H hydrate dehydratase enzyme from vancomycin-resistant Staphylococcus aureus by NMR spectroscopic approach, including saturation transfer difference (STD-NMR) spectroscopy.
Topics: Adenosine Triphosphate; Biological Products; Dehydration; Humans; Hydro-Lyases; Ligands; Magnetic Resonance Spectroscopy; Methicillin-Resistant Staphylococcus aureus; NAD; NADP; Niacinamide; Thiamine; Vancomycin-Resistant Staphylococcus aureus | 2022 |
Nicotinamide riboside and caffeine partially restore diminished NAD availability but not altered energy metabolism in Alzheimer's disease.
Topics: Alzheimer Disease; Caffeine; Energy Metabolism; Humans; NAD; Niacinamide; Pyridinium Compounds | 2022 |
A Versatile Chemoenzymatic Nanoreactor that Mimics NAD(P)H Oxidase for the In Situ Regeneration of Cofactors.
Topics: Biocatalysis; Coenzymes; Glucose; Glucose Oxidase; Hemin; NAD; NADPH Oxidases; Nanotechnology; Niacinamide; Oxidoreductases; Polymers; Regeneration; Solvents | 2022 |
Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase Intracellular NAD
Topics: Animals; Mammals; Mice; NAD; Niacinamide; Pyridinium Compounds | 2022 |
A phosphite-based screening platform for identification of enzymes favoring nonnatural cofactors.
Topics: Enzymes; Escherichia coli; Ligases; NAD; Niacinamide; Oxidation-Reduction; Phosphites | 2022 |
A conserved sequence motif in the Escherichia coli soluble FAD-containing pyridine nucleotide transhydrogenase is important for reaction efficiency.
Topics: Amino Acid Motifs; Amino Acid Sequence; Conserved Sequence; Cysteine; Escherichia coli Proteins; Flavoproteins; Hydrogen Peroxide; NAD; NADP; NADP Transhydrogenase, B-Specific; Niacinamide; Oxygen; Superoxides; Threonine | 2022 |
Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice.
Topics: Adenine Nucleotide Translocator 1; Animals; Mice; Mitochondrial Myopathies; Muscle Weakness; NAD; Niacinamide; Physical Conditioning, Animal; Protein Isoforms; Pyridinium Compounds | 2022 |
Topics: Aged; Animals; Antipsychotic Agents; Arabinose; Cell Wall; Cohort Studies; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Dimyristoylphosphatidylcholine; Electron Transport; Escherichia coli; Female; Ferroptosis; Fibroblasts; Flour; Humans; Indicators and Reagents; Inulin; Ligands; Lipid Bilayers; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Medicare; Membrane Proteins; Mice; NAD; NADPH-Ferrihemoprotein Reductase; Nanostructures; Niacinamide; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Nursing Homes; Pain; Palladium; Phospholipids; Pressure Ulcer; Spectroscopy, Fourier Transform Infrared; Sulfhydryl Compounds; Triticum; United States; Water; Xylans; Xylose | 2021 |
Nicotinamide mitigates radiation injury in submandibular gland by protecting mitochondrial structure and functions.
Topics: Adenosine Triphosphate; Animals; DNA Nucleotidylexotransferase; Humans; Mitochondria; NAD; Niacinamide; Pilocarpine; Prospective Studies; Radiation Injuries; Rats; Rats, Wistar; Submandibular Gland | 2022 |
Topics: Antimalarials; Humans; NAD; Niacin; Niacinamide; Nicotinamidase; Plasmodium falciparum | 2022 |
Lipopolysaccharide affects energy metabolism and elevates nicotinamide N-methyltransferase level in human aortic endothelial cells (HAEC).
Topics: Chromatin; Endothelial Cells; Endothelium; Energy Metabolism; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; NAD; Niacinamide; Nicotinamide N-Methyltransferase; S-Adenosylmethionine | 2022 |
A hydrogen-driven biocatalytic approach to recycling synthetic analogues of NAD(P)H.
Topics: Ethylmaleimide; Hydrogen; Hydrogenase; NAD; Niacinamide; Oxidation-Reduction; Oxidoreductases; Succinimides | 2022 |
An artificial multi-enzyme cascade biocatalysis for biomanufacturing of nicotinamide mononucleotide from starch and nicotinamide in one-pot.
Topics: Biocatalysis; NAD; Niacinamide; Nicotinamide Mononucleotide; Prospective Studies; Starch | 2023 |
Metabolome-wide association study of the relationship between chlorpyrifos exposure and first trimester serum metabolite levels in pregnant Thai farmworkers.
Topics: Biomarkers; Child; Chlorpyrifos; Creatinine; Cystine; Cytochromes; Farmers; Fatty Acids; Female; Glutathione; Humans; Insecticides; Metabolome; NAD; Niacinamide; Organophosphorus Compounds; Pesticides; Pregnancy; Pregnancy Trimester, First; Reactive Oxygen Species; Thailand; Tryptophan | 2022 |
Metabolomic transition trajectory and potential mechanisms of N-nitrosomethylbenzylamine induced esophageal squamous cell carcinoma in rats.
Topics: Animals; Carcinogens; Carcinogens, Environmental; Cell Transformation, Neoplastic; Dimethylnitrosamine; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Metabolome; NAD; Niacin; Niacinamide; Nitrogen; Nitrosamines; Rats; Sphingolipids; Tryptophan; Tumor Microenvironment | 2022 |
Nicotinamide reverses deficits in puberty-born neurons and cognitive function after maternal separation.
Topics: Animals; Bromodeoxyuridine; Cognition; Hippocampus; Interleukin-6; Maternal Deprivation; NAD; Neurons; Niacinamide; Rats; Rats, Wistar; Sexual Maturation; Sirtuin 3; Tumor Necrosis Factor-alpha | 2022 |
Nicotinamide riboside kinase 1 protects against diet and age-induced pancreatic β-cell failure.
Topics: Aging; Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Glucose; Insulin-Secreting Cells; Mice; Mice, Knockout; NAD; Niacinamide; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds | 2022 |
Transcriptional regulation of
Topics: Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinases; Histones; NAD; Niacinamide; Sirtuins | 2022 |
AMPK phosphorylates NAMPT to regulate NAD
Topics: AMP-Activated Protein Kinases; Cytokines; Homeostasis; Humans; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Phosphoribosyl Pyrophosphate; Radiation, Ionizing | 2022 |
Boosting artificial nicotinamide cofactor systems.
Topics: Glucose 1-Dehydrogenase; NAD; NADP; Niacinamide; Oxidation-Reduction; Sugars | 2022 |
Enhancing the biosynthesis of nicotinamide mononucleotide in Lactococcus lactis by heterologous expression of FtnadE.
Topics: Lactococcus lactis; NAD; Niacinamide; Nicotinamide Mononucleotide | 2023 |
PARP-inhibition reprograms macrophages toward an anti-tumor phenotype.
Topics: Adenosine Diphosphate; CD47 Antigen; Cell Line, Tumor; Macrophages; NAD; Niacinamide; Phenotype; Phthalazines; Poly(ADP-ribose) Polymerase Inhibitors; Reactive Oxygen Species | 2022 |
Swim Training Affects on Muscle Lactate Metabolism, Nicotinamide Adenine Dinucleotides Concentration, and the Activity of NADH Shuttle Enzymes in a Mouse Model of Amyotrophic Lateral Sclerosis.
Topics: Adenine; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Lactic Acid; Malate Dehydrogenase; Mice; Monocarboxylic Acid Transporters; Muscle, Skeletal; NAD; Niacinamide | 2022 |
Conformational Preferences of Pyridone Adenine Dinucleotides from Molecular Dynamics Simulations.
Topics: Adenine; Amides; Dapsone; Molecular Dynamics Simulation; NAD; Niacinamide; Pyridones; Ribose | 2022 |
Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells.
Topics: Animals; Humans; Mammals; Mice; NAD; Niacinamide; Purine-Nucleoside Phosphorylase; Pyridinium Compounds | 2022 |
Intravenous Nicotinamide Riboside Administration Has a Cardioprotective Effect in Chronic Doxorubicin-Induced Cardiomyopathy.
Topics: Animals; Cardiomyopathies; Doxorubicin; Male; NAD; Niacinamide; Pyridinium Compounds; Rats; Rats, Wistar | 2022 |
A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD
Topics: Animals; Biosensing Techniques; Humans; NAD; Niacinamide; Pyridinium Compounds; Triple Negative Breast Neoplasms | 2023 |
Maternal heterozygosity of Slc6a19 causes metabolic perturbation and congenital NAD deficiency disorder in mice.
Topics: Amino Acid Transport Systems, Neutral; Animals; Congenital Abnormalities; Female; Heterozygote; Kidney; Mice; NAD; Niacinamide; Pregnancy; Tryptophan | 2023 |
NAPRT, but Not NAMPT, Provides Additional Support for NAD Synthesis in Esophageal Precancerous Lesions.
Topics: Case-Control Studies; Esophageal Neoplasms; Humans; NAD; Niacin; Niacinamide; Nicotinamide Phosphoribosyltransferase; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Precancerous Conditions | 2022 |
Conformational transitions induced by NADH binding promote reduction half-reaction in 2-hydroxybiphenyl-3-monooxygenase catalytic cycle.
Topics: Binding Sites; Catalytic Domain; Flavin-Adenine Dinucleotide; Kinetics; Mixed Function Oxygenases; Models, Molecular; NAD; Niacinamide; Oxidation-Reduction | 2023 |
NAD precursors cycle between host tissues and the gut microbiome.
Topics: Animals; Mammals; Mice; NAD; Niacin; Niacinamide | 2022 |
Sharing the load in NAD metabolism.
Topics: NAD; Niacin; Niacinamide | 2022 |
Topics: Amides; Fluorescence; Methanol; NAD; Niacinamide; Water | 2022 |
NAD Supplement Alleviates Intestinal Barrier Injury Induced by Ethanol Via Protecting Epithelial Mitochondrial Function.
Topics: Animals; Caco-2 Cells; Dietary Supplements; Ethanol; Humans; Intestinal Mucosa; Mice; Mitochondria; NAD; Niacinamide; Sirtuin 1 | 2022 |
Adult patient diagnosed with NADSYN1 associated congenital NAD deficiency and analysis of NAD levels to be published in: European Journal of Medical Genetics.
Topics: Adult; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor; Child; Genetics, Medical; Humans; Limb Deformities, Congenital; Male; Musculoskeletal Abnormalities; NAD; Niacinamide | 2023 |
NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve.
Topics: Animals; Glaucoma; Humans; NAD; Niacinamide; Optic Nerve; Retina; Retinal Ganglion Cells | 2023 |
Photocatalytic Regeneration of a Nicotinamide Adenine Nucleotide Mimic with Water-Soluble Iridium(III) Complexes.
Topics: Iridium; NAD; Niacinamide; Regeneration; Rhodium; Water | 2023 |
Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD
Topics: Allosteric Site; Cytokines; Humans; Longevity; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase | 2023 |
NAD(P)H binding configurations revealed by time-resolved fluorescence and two-photon absorption.
Topics: Catalysis; Fluorescence; NAD; NADP; Niacinamide | 2023 |
Crystal structures of the NAD+-II riboswitch reveal two distinct ligand-binding pockets.
Topics: Ligands; NAD; Niacinamide; Riboswitch; RNA | 2023 |
Nicotinamide mononucleotides alleviated neurological impairment via anti-neuroinflammation in traumatic brain injury.
Topics: Animals; Brain Injuries, Traumatic; NAD; Niacinamide; Nicotinamide Mononucleotide; Rats; Toll-Like Receptor 2 | 2023 |
Source of nicotinamide governs its metabolic fate in cultured cells, mice, and humans.
Topics: Aging; Animals; Cells, Cultured; Cytokines; Humans; Mice; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase | 2023 |
Systematic engineering of Escherichia coli for efficient production of nicotinamide riboside from nicotinamide and 3-cyanopyridine.
Topics: Escherichia coli; NAD; Niacinamide; Pyridinium Compounds | 2023 |
Nicotinamide Adenine Dinucleotide Precursor Suppresses Hepatocellular Cancer Progression in Mice.
Topics: Animals; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Nude; NAD; Niacinamide; Transforming Growth Factor beta | 2023 |
Novel carbon skeletons activate human NicotinAMide Phosphoribosyl Transferase (NAMPT) enzyme in biochemical assay.
Topics: Cytokines; Humans; NAD; Neoplasms; Niacinamide; Nicotinamide Phosphoribosyltransferase; Sirtuins | 2023 |
NAD
Topics: Animals; Cachexia; Humans; Mice; Muscle, Skeletal; NAD; Neoplasms; Niacin; Niacinamide | 2023 |
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency.
Topics: Autophagy; Humans; Mitochondria; NAD; Neurons; Niacinamide; Nicotinamide Mononucleotide | 2023 |
Preclinical Characterization of Pharmacologic NAD
Topics: Arthritis, Rheumatoid; Humans; Leukocytes, Mononuclear; NAD; Niacinamide; Poly(ADP-ribose) Polymerases; Tumor Necrosis Factor Inhibitors | 2023 |
Nicotinamide N-methyltransferase upregulation contributes to palmitate-elicited peroxisome proliferator-activated receptor transactivation in hepatocytes.
Topics: Animals; Fatty Acids; Fatty Liver; Hepatocytes; Humans; Mice; NAD; Niacinamide; Nicotinamide N-Methyltransferase; Palmitates; PPAR gamma; Transcriptional Activation; Up-Regulation | 2023 |
Nicotinamide Antagonizes Lipopolysaccharide-Induced Hypoxic Cell Signals in Human Macrophages.
Topics: Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Lipopolysaccharides; Macrophages; NAD; Niacinamide | 2023 |
Effect of postharvest nicotinamide treatment on NAD
Topics: Catalase; Crop Production; Electron Transport Complex II; Food Storage; Fragaria; Fruit; Gene Expression Regulation, Plant; NAD; NADP; Niacinamide; Oxidation-Reduction; Oxidative Stress; Poly (ADP-Ribose) Polymerase-1; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Ultraviolet Rays | 2023 |
Incubation of protonated NADH or NADPH with ortho-aminobenzaldehyde generates a novel fluorescent nicotinamide dihydroquinazoline condensate.
Topics: Coloring Agents; NAD; NADH, NADPH Oxidoreductases; NADP; Niacinamide; Oxidation-Reduction | 2023 |
A riboside hydrolase that salvages both nucleobases and nicotinamide in the auxotrophic parasite Trichomonas vaginalis.
Topics: Animals; Crystallography, X-Ray; Hydrolases; Models, Molecular; NAD; Niacinamide; Parasites; Protein Binding; Protein Structure, Tertiary; Substrate Specificity; Trichomonas vaginalis | 2023 |
Identification of structural determinants of nicotinamide phosphoribosyl transferase (NAMPT) activity and substrate selectivity.
Topics: Animals; Kinetics; Mammals; NAD; Niacinamide; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Phosphorylation | 2023 |
Impact of sodium pyruvate on the electrochemical reduction of NAD
Topics: Biomimetics; Electrolytes; NAD; Niacinamide; Oxidation-Reduction; Pyruvic Acid; Sodium | 2023 |
Nicotinamide Prevents Diabetic Brain Inflammation via NAD+-Dependent Deacetylation Mechanisms.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Encephalitis; Male; Mice; Mice, Inbred C57BL; NAD; Niacinamide | 2023 |
NAD(H) homeostasis underlies host protection mediated by glycolytic myeloid cells in tuberculosis.
Topics: Animals; Glycolysis; Homeostasis; Lactate Dehydrogenase 5; Mice; Myeloid Cells; NAD; Niacinamide; Tuberculosis | 2023 |
Nicotinamide restores tissue NAD+ and improves survival in rodent models of cardiac arrest.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Heart Arrest; Lactic Acid; Mice; Myocytes, Cardiac; NAD; Niacinamide; Rats; Rodentia | 2023 |
A holistic approach for process intensification of nicotinamide mononucleotide production via high cell density cultivation under exponential feeding strategy.
Topics: Batch Cell Culture Techniques; Bioreactors; Glucose; NAD; Niacinamide; Nicotinamide Mononucleotide | 2023 |
NAD+ Precursors: A Physiological Reboot?
Topics: NAD; Niacin; Niacinamide | 2023 |
Novel Calcium-Binding Motif Stabilizes and Increases the Activity of
Topics: Aspergillus fumigatus; Calcium; Humans; NAD; NAD+ Nucleosidase; Niacinamide | 2023 |
Changing the Electron Acceptor Specificity of
Topics: Carbon Dioxide; Electrons; Formate Dehydrogenases; Kinetics; NAD; NADP; Niacinamide; Oxidants; Oxidation-Reduction; Rhodobacter capsulatus | 2023 |
Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods.
Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Binding Sites; Biophysical Phenomena; Biophysics; Calorimetry; Escherichia coli; Ligands; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Nucleotides; Protein Binding; Structure-Activity Relationship; Thermodynamics | 2006 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |