Page last updated: 2024-08-17

nad and mycophenolic acid

nad has been researched along with mycophenolic acid in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.70)18.7374
1990's7 (30.43)18.2507
2000's10 (43.48)29.6817
2010's4 (17.39)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hedstrom, L; Wang, CC1
Azzolina, BA; Behrens, ND; Hupe, DJ1
Scrimgeour, KG; Wu, TW1
Anderson, WK; Kajtár-Peredy, M; Keserû, GM; Makara, GM1
Bruzzese, FJ; Chambers, SP; Connelly, PR; Fleming, MA; Fox, T; Fulghum, JR; Hoe, ST; Livingston, DJ; Nimmesgern, E; Sintchak, MD; Stuver, CM; Thomson, JA; Wilson, KP1
Hoyt, JC; Parry, RJ1
Goldstein, BM; Lesiak, K; Majumdar, A; Pankiewicz, KW; Powell, J; Seidman, M; Vanderveen, K; Watanabe, KA1
Digits, JA; Hedstrom, L2
Lesiak-Watanabe, K; Malinowski, K; Pankiewicz, KW; Watanabe, KA1
Nimmesgern, E; Sintchak, MD1
Daxecker, H; Müller, MM; Raab, M1
Luecke, H; Prosise, GL1
Clark, JL; Lostia, S; Otto, MJ; Pankiewicz, KW; Patterson, SE; Stuyver, LJ; Watanabe, KA1
Black, PL; Goldstein, BM; Jayaram, HN; Pankiewicz, KW; Patterson, SE; Risal, D; Schinazi, RF; Stuyver, LJ1
Anderson, WK; Bernacki, RJ; El-Araby, ME; Makara, GM; Pera, PJ1
Berg, A; Boitz, JM; Dobie, F; Jardim, A1
Bennett, EM; Bonnac, L; Chen, L; Felczak, K; Gao, G; Hedstrom, L; Jayaram, HN; Pankiewicz, KW; Patterson, SE; Wilson, D1
Brandhorst, G; Coffing, MJ; Domke, I; Liebisch, G; Luthe, H; Marquet, P; Oellerich, M; Schmitz, G; Shaw, LM; Streit, F1
Anderson, WF; Binkowski, TA; Gollapalli, DR; Gornicki, P; Hedstrom, L; Jedrzejczak, R; Joachimiak, A; Kim, Y; Kuhn, ML; Mack, JC; Makowska-Grzyska, M; Maltseva, N; Mulligan, R; Wang, XK; Wilton, R; Wu, R; Zhang, R1
Luvisi, A; Panattoni, A; Rinaldelli, E; Triolo, E1
Bessho, T; Djikeng, A; Duszenko, M; Inui, T; Kubata, KB; Kusumoto, T; Martin, SK; Morii, S; Nishimura, S; Noda, M; Shinohara, T; Shuto, S; Uchiyama, S1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1

Reviews

2 review(s) available for nad and mycophenolic acid

ArticleYear
The structure of inosine 5'-monophosphate dehydrogenase and the design of novel inhibitors.
    Immunopharmacology, 2000, Volume: 47, Issue:2-3

    Topics: Animals; Autoimmune Diseases; Drug Design; Enzyme Inhibitors; Guanine Nucleotides; Humans; Immunosuppressive Agents; IMP Dehydrogenase; Mycophenolic Acid; NAD

2000
Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target.
    Current medicinal chemistry, 2004, Volume: 11, Issue:7

    Topics: Catalysis; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Molecular Mimicry; Molecular Structure; Mycophenolic Acid; NAD; Ribavirin; Ribonucleosides

2004

Other Studies

21 other study(ies) available for nad and mycophenolic acid

ArticleYear
Mycophenolic acid and thiazole adenine dinucleotide inhibition of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: implications on enzyme mechanism.
    Biochemistry, 1990, Jan-30, Volume: 29, Issue:4

    Topics: Adenine Nucleotides; Animals; Binding Sites; Binding, Competitive; IMP Dehydrogenase; Isomerism; Ketone Oxidoreductases; Kinetics; Mycophenolic Acid; NAD; Ribonucleotides; Tritrichomonas; Xanthine

1990
IMP dehydrogenase from the intracellular parasitic protozoan Eimeria tenella and its inhibition by mycophenolic acid.
    The Journal of biological chemistry, 1986, Jun-25, Volume: 261, Issue:18

    Topics: Animals; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Eimeria; Humans; Hypoxanthine Phosphoribosyltransferase; IMP Dehydrogenase; Ketone Oxidoreductases; Kinetics; Liver; Lymphoma; Models, Chemical; Mycophenolic Acid; NAD; Placenta; Rats; Sarcoma 180

1986
Properties of inosinic acid dehydrogenase from Bacillus subtilis. II. Kinetic properties.
    Canadian journal of biochemistry, 1973, Volume: 51, Issue:10

    Topics: Adenosine Monophosphate; Bacillus subtilis; Binding Sites; Binding, Competitive; Catalysis; Cations, Monovalent; Enzyme Activation; Feedback; Guanine Nucleotides; Hot Temperature; Hydrogen-Ion Concentration; Inosine Nucleotides; Ketone Oxidoreductases; Kinetics; Mycophenolic Acid; NAD; Osmolar Concentration; Potassium

1973
Nuclear magnetic resonance and molecular modeling study on mycophenolic acid: implications for binding to inosine monophosphate dehydrogenase.
    Journal of medicinal chemistry, 1996, Mar-15, Volume: 39, Issue:6

    Topics: Enzyme Inhibitors; IMP Dehydrogenase; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Mycophenolic Acid; NAD

1996
Inhibition of IMPDH by mycophenolic acid: dissection of forward and reverse pathways using capillary electrophoresis.
    Biochemistry, 1996, Jun-04, Volume: 35, Issue:22

    Topics: Animals; Base Sequence; Cricetinae; Crystallization; DNA Primers; Electrophoresis, Capillary; Enzyme Inhibitors; Escherichia coli; IMP Dehydrogenase; Inosine Monophosphate; Kinetics; Models, Chemical; Molecular Sequence Data; Mycophenolic Acid; NAD; Protein Binding; Recombinant Proteins

1996
Purification and preliminary characterization of (E)-3-(2,4-dioxo-6-methyl-5-pyrimidinyl)acrylic acid synthase, an enzyme involved in biosynthesis of the antitumor agent sparsomycin.
    Journal of bacteriology, 1997, Volume: 179, Issue:4

    Topics: Acrylates; Amino Acids; Antibiotics, Antineoplastic; Cations; Diethyl Pyrocarbonate; Hypoxanthines; Isoelectric Point; Kinetics; Molecular Weight; Mycophenolic Acid; NAD; Oxygenases; Purines; Pyrimidinones; Sparsomycin; Streptomyces; Substrate Specificity; Sulfhydryl Reagents

1997
Synthesis of a methylenebis(phosphonate) analogue of mycophenolic adenine dinucleotide: a glucuronidation-resistant MAD analogue of NAD.
    Journal of medicinal chemistry, 1998, Feb-12, Volume: 41, Issue:4

    Topics: Adenine Nucleotides; Antineoplastic Agents; Biotransformation; Cell Division; Glucuronates; Glucuronosyltransferase; Humans; IMP Dehydrogenase; Indicators and Reagents; Molecular Structure; Mycophenolic Acid; NAD; Structure-Activity Relationship; Tumor Cells, Cultured

1998
Kinetic mechanism of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase.
    Biochemistry, 1999, Feb-23, Volume: 38, Issue:8

    Topics: Amino Acid Substitution; Animals; Binding Sites; Cysteine; Deuterium; Humans; IMP Dehydrogenase; Kinetics; Ligands; Models, Chemical; Mutagenesis, Site-Directed; Mycophenolic Acid; NAD; Protein Binding; Serine; Spectrometry, Fluorescence; Thermodynamics; Tritrichomonas foetus

1999
Novel mycophenolic adenine bis(phosphonate)s as potential immunosuppressants.
    Current medicinal chemistry, 1999, Volume: 6, Issue:7

    Topics: Dose-Response Relationship, Drug; HT29 Cells; Humans; Immunosuppressive Agents; IMP Dehydrogenase; K562 Cells; Kinetics; Mycophenolic Acid; NAD

1999
Drug selectivity is determined by coupling across the NAD+ site of IMP dehydrogenase.
    Biochemistry, 2000, Feb-22, Volume: 39, Issue:7

    Topics: Adenosine Diphosphate; Animals; Cricetinae; Cricetulus; Drug Resistance; Drug Synergism; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Mutagenesis, Site-Directed; Mycophenolic Acid; NAD; Ribavirin; Spectrometry, Fluorescence; Tritrichomonas foetus; Tryptophan

2000
Influence of mycophenolic acid on inosine 5'-monophosphate dehydrogenase activity in human peripheral blood mononuclear cells.
    Clinica chimica acta; international journal of clinical chemistry, 2002, Volume: 318, Issue:1-2

    Topics: Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Indicators and Reagents; Kinetics; Monocytes; Mycophenolic Acid; NAD; Spectrophotometry, Ultraviolet

2002
Crystal structures of Tritrichomonasfoetus inosine monophosphate dehydrogenase in complex with substrate, cofactor and analogs: a structural basis for the random-in ordered-out kinetic mechanism.
    Journal of molecular biology, 2003, Feb-14, Volume: 326, Issue:2

    Topics: Animals; Binding Sites; Catalysis; Crystallization; Crystallography, X-Ray; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Inosine Monophosphate; Kinetics; Models, Molecular; Mycophenolic Acid; NAD; Protein Conformation; Ribavirin; Ribonucleotides; Tritrichomonas foetus; Xanthine

2003
Inhibitors of the IMPDH enzyme as potential anti-bovine viral diarrhoea virus agents.
    Antiviral chemistry & chemotherapy, 2002, Volume: 13, Issue:6

    Topics: Animals; Cattle; Cell Line; Computer Systems; Culture Media, Conditioned; Diarrhea Viruses, Bovine Viral; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Guanosine Triphosphate; IMP Dehydrogenase; Kidney; Molecular Structure; Mycophenolic Acid; NAD; Nucleosides; Reverse Transcriptase Polymerase Chain Reaction; Ribavirin; Ribonucleosides; Viral Plaque Assay; Virus Replication

2002
Synthesis, molecular modeling, and evaluation of nonphenolic indole analogs of mycophenolic acid.
    Bioorganic & medicinal chemistry, 2004, Jun-01, Volume: 12, Issue:11

    Topics: Animals; Binding Sites; Cell Line, Tumor; Cricetinae; Humans; IMP Dehydrogenase; Indoles; Models, Molecular; Mycophenolic Acid; NAD; Structure-Activity Relationship

2004
Kinetic characterization of inosine monophosphate dehydrogenase of Leishmania donovani.
    Molecular and biochemical parasitology, 2007, Volume: 152, Issue:1

    Topics: Amino Acid Sequence; Animals; Enzyme Inhibitors; Escherichia coli; Guanosine Monophosphate; Inosine Monophosphate; Leishmania donovani; Microbodies; Microscopy, Confocal; Mycophenolic Acid; NAD; Peroxisome-Targeting Signal 1 Receptor; Phylogeny; Protein Binding; Protozoan Proteins; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Ribonucleotides; Sequence Alignment; Subcellular Fractions; Substrate Specificity; Xanthine

2007
Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues.
    Journal of medicinal chemistry, 2007, Nov-15, Volume: 50, Issue:23

    Topics: Adenosine Monophosphate; Antineoplastic Agents; Diphosphonates; Drug Screening Assays, Antitumor; Humans; IMP Dehydrogenase; Isoenzymes; K562 Cells; Models, Molecular; Mycophenolic Acid; NAD; Protein Binding; Ribavirin

2007
Multicenter evaluation of a new inosine monophosphate dehydrogenase inhibition assay for quantification of total mycophenolic acid in plasma.
    Therapeutic drug monitoring, 2008, Volume: 30, Issue:4

    Topics: Antibody Specificity; Chromatography, High Pressure Liquid; Cross Reactions; Drug Monitoring; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Inosine Monophosphate; Mass Spectrometry; Mycophenolic Acid; NAD; Reproducibility of Results

2008
Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes.
    Biochemistry, 2012, Aug-07, Volume: 51, Issue:31

    Topics: Amino Acid Sequence; Apoenzymes; Bacillus anthracis; Benzimidazoles; Catalytic Domain; Enzyme Inhibitors; IMP Dehydrogenase; Inosine Monophosphate; Models, Molecular; Molecular Sequence Data; Mycophenolic Acid; NAD; Protein Binding; Ribonucleotides; Triazoles; Xanthine

2012
Effect of mycophenolic acid on trans-plasma membrane electron transport and electric potential in virus-infected plant tissue.
    Plant physiology and biochemistry : PPB, 2012, Volume: 60

    Topics: Analysis of Variance; Antiviral Agents; Cell Membrane; Cucumovirus; Electron Transport; Enzyme Inhibitors; Membrane Potentials; Mycophenolic Acid; NAD; Nicotiana; Plant Diseases; Plant Leaves

2012
Characterization of the novel Trypanosoma brucei inosine 5'-monophosphate dehydrogenase.
    Parasitology, 2013, Volume: 140, Issue:6

    Topics: Amino Acid Sequence; Animals; Binding Sites; Escherichia coli; Humans; Hydrogen-Ion Concentration; IMP Dehydrogenase; Inosine Monophosphate; Kinetics; Mycophenolic Acid; NAD; Nucleotides; Protein Multimerization; Recombinant Proteins; Ribonucleosides; Sequence Alignment; Trypanosoma brucei brucei

2013
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010