nad has been researched along with lysine in 243 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 86 (35.39) | 18.7374 |
| 1990's | 39 (16.05) | 18.2507 |
| 2000's | 48 (19.75) | 29.6817 |
| 2010's | 47 (19.34) | 24.3611 |
| 2020's | 23 (9.47) | 2.80 |
| Authors | Studies |
|---|---|
| Colman, RF | 1 |
| Zanetti, G | 1 |
| Hack, E; Kemp, JD | 1 |
| Beugnier, N; Zanen, J | 1 |
| Re, L; Rossodivita, A; Zappelli, P | 1 |
| Harrison, JH; Wimmer, MJ | 1 |
| Fujioka, M | 1 |
| Chen, SS; Engel, PC | 3 |
| Bevilacqua, R; Boccù, E; Brown, DM; Veronese, FM | 1 |
| Colman, RF; Hayman, S | 1 |
| Fujioka, M; Sugimoto, K | 1 |
| Hoffmann-Ostenhof, O; Pittner, F | 1 |
| Blaner, WS; Churchich, J | 1 |
| Burzio, LO; Koide, SS; Riquelme, PT | 1 |
| Barbeau, A; Ngo, TT | 1 |
| Colman, RF; Shen, WC | 1 |
| Levy, HR; Milhausen, M | 1 |
| Coudert, M; Lemal, J; Vandecasteele, JP | 1 |
| Nakagawa, H; Ogura, N; Sato, T; Sato, Y; Shiraishi, N | 1 |
| Hashimoto, H; Misono, H; Nagasaki, S; Nagata, S | 1 |
| Coghill, JE; Kittler, JM; Strittmatter, P | 1 |
| Chen, Z; Colman, RF; Haeffner-Gormley, L; Zalkin, H | 1 |
| Burnette, WN; Kaslow, HR; Mar, VL; McGinley, MD; Platler, BW; Rohde, MF; Schlotterbeck, JD; Stoney, KS | 1 |
| Folk, JE; Park, MH; Wolff, EC | 1 |
| Chen, KY; Dou, QP | 2 |
| Appleman, R; Blakley, RL; Freisheim, JH; Huang, S; Sheridan, RP; Tan, XH; Thompson, PD; Venkataraghavan, R | 1 |
| Amrhein, N; Laber, B | 1 |
| Carrea, G; Mazzola, G; Pasta, P | 1 |
| Berden, JA; Hartog, AF; Persson, B; Rydström, J | 1 |
| Hackett, CS; Kensil, CR; Novoa, WB; Strittmatter, P | 1 |
| Park, MH; Wolff, EC | 1 |
| Eckel, RE; Simonson, MS | 1 |
| Gilvarg, C; Tamir, H | 1 |
| Fujioka, M; Nakatani, Y | 3 |
| Broquist, HP; Saunders, PP | 1 |
| Polgár, L | 1 |
| Bürgi, W; Colombo, JP; Richterich, R | 1 |
| Aoki, T; Fujioka, M; Higashino, K; Yamamura, T | 1 |
| Mathew, E; Meriwether, BP; Park, JH | 1 |
| Jacobs, RM; Williams, JN | 1 |
| Barker, HA; Dekker, EE | 1 |
| Loverde, A; Strittmatter, P | 1 |
| Dalton, BP; Hochstein, LI | 1 |
| Barker, HA; Rimerman, EA | 1 |
| Hayaishi, O; Nozaki, M | 1 |
| Furuno, I; Matsudaira, H; Otsuka, H | 1 |
| Barker, HA; Winnacker, EL | 1 |
| Schwert, GW; Yang, PC | 2 |
| Davidson, BE | 1 |
| Crane, FL; Ruzicka, FJ | 1 |
| D'Alessio, G; Josse, J | 1 |
| Barnes, EM; Kaback, HR; Konings, WN | 1 |
| Sinha, AK | 1 |
| Frieden, C; Goldin, BR | 2 |
| Bradshaw, RA; Coffee, CJ; Frieden, C; Goldin, BR | 1 |
| McKinley-McKee, JS; Morris, DL | 1 |
| Huc, C; Lefebure, F; Olomucki, A; Van Thoai, N | 1 |
| Fujioka, M; Higashino, K; Nakatani, Y | 1 |
| Baker, JJ; Barker, HA; Jeng, I | 1 |
| Hucho, F; Markau, U; Sund, H | 1 |
| MacLeod, RA; Rogers, HJ; Thurman, P | 1 |
| Jörnvall, H | 1 |
| Holbrook, JJ; Wallis, RB | 1 |
| Sugimura, T; Yamada, M | 1 |
| Fan, CC; Plaut, GW | 1 |
| Cheng, ST; Lauzon, G; Tsai, CS; Tsai, YH | 1 |
| Paulus, H; Sarkar, N | 1 |
| Kaback, HR; Lombardi, FJ; Reeves, JP; Short, SA | 1 |
| Foucault, G; Levilliers, J; Pudles, J; Traore, F | 1 |
| Chernukh, AM; Chernysheva, GV | 1 |
| Degani, Y; Smith, EL; Veronese, FM | 1 |
| Degani, Y; Nyc, JF; Smith, EL; Veronese, FM | 1 |
| Broquist, HP; Jones, EE | 1 |
| Levine, L; Seaman, E; Setlow, P; van Vunakis, H | 1 |
| Henderson, LM; Hiles, RA; Triebwasser, KC | 1 |
| Fujioka, M; Higashino, K; Yamamura, Y | 1 |
| Geroch, ME; Levy, HR; Olive, C | 1 |
| LéJohn, HB | 1 |
| Piszkiewicz, D; Smith, EL | 2 |
| Colman, RF; Schmidt, JA | 1 |
| Bednar, RA; Colman, RF; Saradambal, KV | 1 |
| Misono, H; Nagasaki, S | 1 |
| Engel, PC; Gould, KG | 1 |
| Katiyar, SS; Sheikh, S | 3 |
| Gomi, T; Itagaki, E; Mizuguchi, M; Suzuki, K | 1 |
| Chen, HH; Chen, S; Deng, PS; Forrest, GL; Massey, V; Tedeschi, G | 1 |
| Katiyar, SS; Pandey, A | 1 |
| Böhm, G; Jaenicke, R; Tomschy, A | 1 |
| Faraone-Mennella, MR; Farina, B | 1 |
| Cunningham, SJ; Farrés, J; Takahashi, K; Wang, TT; Wang, X; Weiner, H | 1 |
| Ensor, CM; Tai, HH | 1 |
| Guest, JR; Maeda-Yorita, K; Massey, V; Russell, GC; Williams, CH | 1 |
| Frey, PA; Swanson, BA | 1 |
| Amzel, LM; Bosron, WF; Dunn, MF; Hurley, TD; Stone, CL | 1 |
| Atkinson, T; Gore, MG; Paine, LJ; Perry, N; Popplewell, AG | 1 |
| Fujimoto, Y; Nagai, T; Shirabe, K; Takeshita, M; Yubisui, T | 1 |
| Clonis, YD; Eliopoulos, E; Labrou, NE | 1 |
| Katiyar, S; Pandey, A; Sheikh, S | 1 |
| Aiba, H; Mizuno, T; Ohmiya, R; Yamada, H | 1 |
| Handelman, G; Konishi, T; Mathur, VV; Matsugo, S; Packer, L; Tritschler, HJ | 1 |
| de Murcia, G; Jacobson, MK; Kim, H; Ménissier-de Murcia, J; Reinbolt, J; Rolli, V; Ruf, A; Schulz, G; Simonin, F | 1 |
| Cho, SW; Choi, SY; Kim, SW; Lee, J; Song, MS | 1 |
| Hurley, TD; Ni, L; Sheikh, S; Weiner, H | 1 |
| de La Fuente, JL; Liras, P; Martín, JF; Rumbero, A | 1 |
| Aghajanian, S; Engel, PC; Goyal, A; Hayden, BM; Wang, XG | 1 |
| Hol, WG; Pizza, M; Rappuoli, R; van den Akker, F | 1 |
| Davies, DR; Liao, DI; Park, MH; Wolff, EC | 1 |
| Akiba, S; Konishi, T; Matsugo, S; Packer, L | 1 |
| Hong, YS; Korotchkina, LG; Liu, TC; Patel, MS; Vettakkorumakankav, NN | 1 |
| LeBrun, LA; Plapp, BV | 1 |
| Moynihan, DP; Parikh, S; Tonge, PJ; Xiao, G | 1 |
| Poulsen, LL; Robertus, JD; Suh, JK; Ziegler, DM | 1 |
| Heller, RC; Landry, J; Pillus, L; Stebbins, J; Sternglanz, R; Sutton, A; Tafrov, ST | 1 |
| Asao, E; Fukuda, S; Nakamura, M; Nakamura, Y; Ohnishi, K; Suzuki, K | 1 |
| Cook, PF; Karsten, WE; Liu, D | 1 |
| Weiner, H; Zhou, J | 1 |
| Kudo, T; Park, SY; Shiro, Y; Shoun, H; Takaya, N | 1 |
| Lee, CH; Park, MH | 1 |
| Adams, MJ; Ciccone, T; Cosgrove, MS; Davino, MH; Fairbairn, L; Levy, HR; Lin, Y; Vought, V | 1 |
| Borchardt, RT; Robins, MJ; Wnuk, SF; Yang, X; Yin, D | 1 |
| Sciotti, M; Wermuth, B | 1 |
| Clarke, AR; Holbrook, JJ; Kedzierski, P; Moreton, K | 1 |
| Cleland, WW; Frey, PA; Gerratana, B | 1 |
| Barber, MJ; Desai, SK; Marohnic, CC | 1 |
| Barber, MJ; Bewley, MC; Marohnic, CC | 1 |
| Esposito, C; Francese, S; Marino, G; Orru, S; Ruoppolo, M; Vitagliano, L | 1 |
| Dasgupta, S; Datta, D; Fulzele, K; Kundu, PK; Sewlikar, S | 1 |
| Fujioka, M; Gomi, T; Huang, Y; Komoto, J; Ogawa, H; Takata, Y; Takusagawa, F; Yamada, T | 1 |
| Dauter, M; Hottinger, H; Kochhar, S; Lamzin, VS; Razeto, A; Wilson, KS | 1 |
| Boeke, JD; Celic, I; Cole, RN; Escalante-Semerena, JC; Starai, VJ | 1 |
| Garcia, SN; Kadonaga, JT; Parsons, XH; Pillus, L | 1 |
| Atrian, S; Benach, J; Gonzàlez-Duarte, R; Karshikoff, A; Koumanov, A; Ladenstein, R | 1 |
| Folk, JE; Park, JH; Park, MH; Wolff, EC | 1 |
| Sauve, AA; Schramm, VL | 1 |
| STRASSMAN, M | 1 |
| SHIFRIN, S | 1 |
| NERMUT, MV | 1 |
| Avalos, JL; Boeke, JD; Wolberger, C | 1 |
| Achilli, A; Barbiroli, B; Barboni, P; Baruzzi, A; Bucchi, L; Carelli, V; Dotti, M; Federico, A; Ghelli, A; Lodi, R; Lugaresi, A; Rengo, C; Torroni, A; Valentino, ML | 1 |
| Bouras, T; Fu, M; Gu, W; Hay, RT; Perkins, ND; Pestell, RG; Quong, AA; Sauve, AA; Wang, F | 1 |
| Leitgeb, S; Nidetzky, B; Petschacher, B; Wilson, DK | 1 |
| Christendat, D; Collart, F; Joachimiak, A; Korolev, S; Koroleva, O; Singh, S; Zarembinski, T | 1 |
| Cook, PF; Harris, BG; Karsten, WE; Liu, D; Rao, GS | 1 |
| Gygi, SP; Haas, W; Lerin, C; Puigserver, P; Rodgers, JT; Spiegelman, BM | 1 |
| Ballou, DP; Brinker, DR; Casas, KR; Galloway, LJ; Scannell, SA; Trimmer, EE | 1 |
| Kruger, RG; Liou, GG; Moazed, D; Tanny, JC; Walz, T | 1 |
| Hurley, TD; Larson, HN; Weiner, H | 1 |
| Denu, JM; Garske, AL | 1 |
| Khan, AN; Lewis, PN | 1 |
| Basran, J; Combe, JP; Hothi, P; Leys, D; Munro, AW; Rigby, SE; Scrutton, NS | 1 |
| Cook, PF; West, AH; Xu, H | 1 |
| Denu, JM; Smith, BC | 1 |
| Escalante-Semerena, JC; Gardner, JG; Garrity, J; Hawse, W; Wolberger, C | 1 |
| Reinberg, D; Sternglanz, R; Vaquero, A | 1 |
| Duraisingh, MT; Merrick, CJ | 1 |
| Berghuis, AM; Burk, DL; Dmitrienko, GI; Goodfellow, V; Hwang, J; Kwok, E; Marrone, L | 1 |
| Bastkowski, F; Klärner, FG; Schrader, T; Talbiersky, P | 1 |
| Chen, D; Grimaldi, B; Guarente, LP; Hirayama, J; Kaluzova, M; Nakahata, Y; Sahar, S; Sassone-Corsi, P | 1 |
| Cen, Y; French, JB; Sauve, AA | 1 |
| Du, H; Lin, X; Lin, Y; Zeng, Q; Zhai, Z | 1 |
| Hayashi, YK; Matsuda, C; Minami, N; Mitsuhashi, H; Nishino, I; Noguchi, S; Nonaka, I; Shalaby, S | 1 |
| Buratowski, S; Johnson, A; Li, G; Moazed, D; Sikorski, TW; Woodcock, CL | 1 |
| Lu, Z; Sack, MN; Scott, I; Webster, BR | 1 |
| Chang, YH; Chiu, CC; Chuang, LY; Hwang, CC; Wang, CZ | 1 |
| Fukuda, J; Ohshima, T; Sakuraba, H; Yoneda, K | 1 |
| Sauve, AA | 1 |
| Andi, B; Bobyk, KD; Cook, PF; Ekanayake, DK; West, AH | 1 |
| Cen, Y; Sauve, AA | 1 |
| Brookes, PS; Nadtochiy, SM; Rahman, I; Redman, E | 1 |
| Bobyk, KD; Cook, PF; Kim, SG; Kim, SK; Kumar, VP; West, AH | 1 |
| Cook, PF; Ekanayake, DK; West, AH | 1 |
| Efremov, RG; Sazanov, LA | 1 |
| Brookes, PS; Gu, W; Guarente, L; McBurney, MW; Nadtochiy, SM; Rahman, I; Yao, H | 1 |
| Auwerx, J; Cerione, RA; Chen, W; Choi, BH; Du, J; Hao, Q; He, B; Jiang, H; Khan, S; Kim, J; Kim, JH; Lin, H; Su, X; Woo, J; Yu, JJ; Zhang, S; Zhou, Y | 1 |
| Davis, NY; Horita, DA; Lewis, EM; Wilkinson, AS; Wilkinson, JC | 1 |
| Andi, B; Bobyk, KD; Cook, PF; Kumar, VP; Thomas, LM; West, AH | 1 |
| Deshpande, MV; Joshi, CV; Kapadnis, BP; Pathan, EK; Punekar, NS; Tupe, SG | 1 |
| Hubbard, BP; Sinclair, DA | 1 |
| Lin, H; Su, X; Zhu, A | 1 |
| Kugimiya, A; Takamitsu, E | 1 |
| Boersema, PJ; Braun, HP; Fernie, AR; Finkemeier, I; Hartl, M; Kalitventseva, I; König, AC; Laxa, M; Leister, D; Mann, M; Orwat, A; Pham, PA; Plöchinger, M; Wachter, A | 1 |
| Babot, M; Birch, A; Botting, CH; Fuszard, M; Galkin, A; Heide, H; Kee, S; Labarbuta, P; Wittig, I | 1 |
| Gao, H; Kim, SC; Lee, JK; Singh, RK; Sung, BH; Tiwari, MK | 1 |
| Dölle, C; Skoge, RH; Ziegler, M | 1 |
| Guo, Y; Han, M; Xu, J; Zhang, J; Zhang, W | 1 |
| Asriyantz, RA; Gaillard, C; Haertlé, T; Muronetz, VI; Semenyuk, PI; Stroylova, YY | 1 |
| Chen, Z; Cole, PA; Karukurichi, KR; Kavran, JM; Leahy, DJ; Wang, Y | 1 |
| Bi, L; Chen, C; Chen, Y; Cheng, Z; Deng, J; Ge, F; Gu, J; Mo, R; Wang, X; Wang, Y; Yang, M | 1 |
| Hirschey, MD; Zhao, Y | 1 |
| Cruz, C; Houseley, J; Hull, RM; Jack, CV; Keller, MA; Ralser, M | 1 |
| Shen, Y; Wei, W; Zhou, DX | 1 |
| Kim, KJ; Sagong, HY | 1 |
| Andersen, C; Anderson, KA; Backos, DS; Chakladar, S; Colaço, AR; Daoud, M; Fristrup, P; Hirschey, MD; Huynh, FK; Laursen, JS; Madsen, AS; Olsen, CA | 1 |
| Abdelwahab, H; Adly, C; El-Sohaimy, S; Robinson, R; Rodriguez, P; Sobrado, P | 1 |
| Tursun, A; Vik, SB; Zhu, S | 1 |
| Carranza, PG; Gargantini, PR; Lujan, HD; Prucca, CG; Saura, A; Svärd, S; Torri, A | 1 |
| Lou, Z; Nowsheen, S; Pei, H; Qin, B; Qin, S; Shan, S; Wang, L; Wu, F; Yu, J; Zayas, J | 1 |
| Goldgur, Y; Shuman, S; Unciuleac, MC | 1 |
| Dudzik, A; Jemioła-Rzemińska, M; Skoczowski, A; Stawoska, I; Strzałka, K; Szaleniec, M; Wasylewski, M | 1 |
| Chen, Q; Cheng, X; Ji, S; Jing, L; Li, GB; Li, WJ; Liu, S; Wang, HL; Wu, Y; Yang, LL; Yu, Y; Yu, ZJ | 1 |
| Atger, F; Cantó, C; Collino, S; Da Silva, L; Dayon, L; Gachon, F; Kussmann, M; Martin, E; Martin, FP; Mauvoisin, D; Montoliu, I; Naef, F; Núñez Galindo, A; Ratajczak, J; Wang, J | 1 |
| Devenish, SRA; Goldstone, DC; Grant Pearce, F; Keown, JR; Richards, E; Watkin, SAJ | 1 |
| Buccella, D; Gautam, R; Klyubka, Y; Rooker, DR; Tomat, E | 1 |
| Cánovas Díaz, M; de Diego Puente, T; Écija Conesa, A; Gallego-Jara, J; Lozano Terol, G | 1 |
| Escalante-Semerena, JC; VanDrisse, CM | 1 |
| Shao, B; Tian, L; Yan, Y; Zhou, W; Zhu, B | 1 |
| Cen, Y; Graham, E; Rymarchyk, S; Wood, M | 1 |
| Kanai, M; Kato, D; Kawashima, SA; Kurumizaka, H; Liu, J; Tanabe, K; Yamatsugu, K | 1 |
| Hong, JY; Lin, H; Zhang, X | 1 |
| Chen, Z; Liu, D; Wu, W; Zhang, Y | 1 |
| Dayon, L; Santo-Domingo, J; Wiederkehr, A | 1 |
| Ahmed, A; Buenrostro, JD; Conde, J; Escalante, GO; Garbern, JC; Krähenbühl, G; Lee, RT; Ma, S; Sarikhani, M; Sereda, R | 1 |
| Chen, M; Gai, Z; Okada, C; Yao, M; Ye, Y; Yu, J | 1 |
| Albecka, A; Douse, CH; Freund, SMV; Lehner, PJ; Modis, Y; Prigozhin, DM; Protasio, AV; Seczynska, M; Tchasovnikarova, IA; Timms, RT; Wagstaff, J; Williamson, JC | 1 |
| Bonneil, É; Brenner, C; Ghugari, R; Schmidt, M; Tsao, S; Verreault, A | 1 |
| Antrobus, R; Ding, S; Fearnley, IM; Houghton, JW; James, AM; Murphy, MP; Robinson, AJ; Smith, AC | 1 |
| Crosby, P; Fribourgh, JL; Greco, CM; Huang, H; Jang, C; Kim, JK; Koronowski, KB; Mathur, L; Partch, CL; Qiao, F; Ren, X; Sassone-Corsi, P; Zhao, Y | 1 |
| Appanna, VD; Legendre, F; MacLean, A; Tharmalingam, S | 1 |
| Benigni, A; Brizi, V; Buttò, S; Conti, S; Corna, D; Imberti, B; Morigi, M; Perico, L; Pezzotta, A; Remuzzi, G; Sangalli, F; Tomasoni, S; Trionfini, P; Xinaris, C; Zanchi, C; Zoja, C | 1 |
| Zheng, W | 1 |
| Han, HZ; Li, XZ; Liu, D; Wang, B; Yu, ND | 1 |
| Brown, H; Gelin, M; Hoxhaj, G; Kesavan, R; Labesse, G; Lemoff, A; Lionne, C; Mary, C; Mathews, TP; Soflaee, MH; Zacharias, G | 1 |
| Ambrus, A; Houten, SM; Jordan, F; Leandro, J; Nagy, B; Nemeria, NS; Sanchez, R; Zhang, X | 1 |
| Cao, Y; Li, D; Li, J; Liu, N; Luo, Y; Niu, K; Qiu, J; Wang, H; You, Y; Zhang, Y; Zhu, Z | 1 |
| Bielska, O; Chen, IP; Cruz, A; Gross, JD; Hayashi, JM; Jerome, KR; Kim, IJ; Krogan, NJ; Lam, VL; Ott, M; Schilling, B; Shah, S; Soveg, FW; Vallejo-Gracia, A; Verdin, E; Walter, M | 1 |
| Asamizu, S; Hoshino, S; Ijichi, S; Itoh, Y; Jo, H; Matsumoto, S; Onaka, H; Takahashi, H | 1 |
| Liu, Y; Shi, G | 1 |
| Meleshin, M; Schutkowski, M; Sippl, W; Zessin, M | 1 |
| Kundu, TK; Senapati, P; Singh, S | 1 |
| Li, L; Li, N; Yu, S; Zhou, J | 1 |
| Chen, S; Cheng, K; Debnath, B; Han, H; Liang, B; Liu, Y; Lombard, DB; Neamati, N; Shu, K; Wang, Q; Wu, M; Yao, J; Yin, Y; Zheng, Y | 1 |
| Auwerx, J; Baek, S; Fang, S; Jeon, J; Jeon, JH; Jung, HY; Kim, B; Kim, KT; Kim, MJ; Lee, D; Lee, IK; Lim, CW; Oh, CJ; Park, BY; Park, O; Ryu, D | 1 |
| Wang, J; Wang, Y; Wu, Q; Zhang, Y | 1 |
10 review(s) available for nad and lysine
| Article | Year |
|---|---|
Evaluation of the chemiosmotic interpretation of active transport in bacterial membrane vesicles.
Topics: Benzenesulfonates; Biological Transport, Active; Carbon Radioisotopes; Cell Membrane; Cytochromes; Dinitrophenols; Escherichia coli; Kinetics; Lactose; Lysine; Mercury; NAD; Organoids; Organometallic Compounds; Oxygen Consumption; Potassium; Proline; Rubidium; Serine; Succinates; Tyrosine; Valinomycin | 1974 |
NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs.
Topics: Acetylation; Aging; Diabetes Mellitus; Histone Deacetylases; Histones; Humans; Lysine; NAD; Neoplasms; Sirtuins | 2007 |
The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology.
Topics: Acetylation; Acetyltransferases; Animals; Apoptosis; Cardiovascular Diseases; Cardiovascular System; Cell Nucleus; Cytoplasm; Energy Metabolism; Humans; Lysine; Mitochondria; Mitochondria, Heart; Mitochondrial Proteins; NAD; Oxidation-Reduction; Oxidative Stress; Protein Processing, Post-Translational; Signal Transduction; Sirtuins | 2009 |
Sirtuin chemical mechanisms.
Topics: Acetylation; Adenosine Diphosphate Ribose; Animals; Benzimidazoles; Humans; Imidoesters; Lysine; Models, Biological; Molecular Structure; NAD; Niacinamide; Plasmodium falciparum; Saccharomyces cerevisiae; Sirtuins; Trypanosoma brucei brucei | 2010 |
Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation.
Topics: Acylation; Animals; Gene Expression Regulation; Humans; Intracellular Space; Lysine; NAD; Protein Processing, Post-Translational; Proteins; Sirtuins | 2015 |
Histone Acetylation Enzymes Coordinate Metabolism and Gene Expression.
Topics: Acetyl Coenzyme A; Acetylation; Epigenesis, Genetic; Histone Acetyltransferases; Histone Deacetylases; Histones; Lysine; NAD; Plants | 2015 |
Protein Lysine Acetylation: Grease or Sand in the Gears of β-Cell Mitochondria?
Topics: Acetylation; Animals; Diabetes Mellitus, Type 2; Insulin-Secreting Cells; Lysine; Mitochondria; Mitochondrial Proteins; NAD; Oxidative Phosphorylation; Oxidative Stress; Protein Processing, Post-Translational; Sirtuin 3 | 2020 |
The Zinc-dependent HDACs: Non-histone Substrates and Catalytic Deacylation Beyond Deacetylation.
Topics: Animals; Catalysis; Histones; Lysine; Mammals; NAD; Sirtuin 1; Sirtuins; Zinc | 2022 |
Roles of sirtuins in asthma.
Topics: Asthma; Humans; Inflammation; Lysine; NAD; Sirtuins | 2022 |
Metabolic Regulation of Lysine Acetylation: Implications in Cancer.
Topics: Acetyl Coenzyme A; Acetylation; Humans; Lysine; NAD; Neoplasms; Protein Processing, Post-Translational | 2022 |
233 other study(ies) available for nad and lysine
| Article | Year |
|---|---|
Mechanisms for the oxidative decarboxylation of isocitrate: implications for control.
Topics: Carboxylic Acids; Decarboxylation; Hydrogen-Ion Concentration; Isocitrate Dehydrogenase; Isocitrates; Kinetics; Lysine; Methionine; Models, Chemical; NAD; NADP; Sulfhydryl Compounds | 1975 |
A lysyl residue at the NADP binding site of ferredoxin-NADP reductase.
Topics: Adenosine Monophosphate; Binding Sites; Dansyl Compounds; Ferredoxin-NADP Reductase; Ferredoxins; Flavin-Adenine Dinucleotide; Lysine; NAD; NADH, NADPH Oxidoreductases; NADP; Protein Binding; Protein Conformation; Spectrophotometry | 1976 |
Comparison of octopine, histopine, lysopine, and octopinic acid synthesizing activities in sunflower crown gall tissues.
Topics: Amino Acids; Arginine; Histidine; Lysine; NAD; NADP; Ornithine; Plant Diseases; Pyruvates; Rhizobium | 1977 |
Diphtheria toxin: the effect of nitration and reductive methylation on enzymatic activity and toxicity.
Topics: Binding Sites; Borohydrides; Chemical Phenomena; Chemistry; Diphtheria Toxin; Epitopes; Formaldehyde; HeLa Cells; Lysine; NAD; Oxidation-Reduction; Peptide Elongation Factors; Structure-Activity Relationship; Tetranitromethane; Tyrosine | 1977 |
Synthesis of coenzymically active soluble and insoluble macromolecularized NAD+ derivatives.
Topics: Alanine; Alcohol Oxidoreductases; Amino Acid Oxidoreductases; Animals; Bacillus subtilis; Chromatography, Gas; Chromatography, Gel; Chromatography, Thin Layer; Electrophoresis, Paper; L-Lactate Dehydrogenase; Lysine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methods; Muscles; NAD; Optical Rotation; Peptides; Polymers; Rabbits; Saccharomyces cerevisiae; Solubility; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1975 |
Identification of an essential lysine in porcine heart mitochondrial malate dehydrogenase.
Topics: Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Lysine; Malate Dehydrogenase; Mitochondria, Muscle; Myocardium; NAD; Peptide Fragments; Protein Binding; Pyridoxal Phosphate; Swine; Trypsin | 1975 |
Saccharopine dehydrogenase. Substrate inhibition studies.
Topics: Ketoglutaric Acids; Kinetics; Lysine; Mathematics; NAD; Oxidoreductases Acting on CH-NH Group Donors; Saccharomyces cerevisiae; Saccharopine Dehydrogenases | 1975 |
Ox liver glutamate dehydrogenase. The role of lysine-126 reappraised in the light of studies of inhibition and inactivation by pyridoxal 5'-phosphate.
Topics: Animals; Binding Sites; Binding, Competitive; Cattle; Glutamate Dehydrogenase; Ketoglutaric Acids; Kinetics; Liver; Lysine; NAD; Pyridoxal Phosphate | 1975 |
Horse liver alcohol dehydrogenase. A study of the essential lysine residue.
Topics: Alcohol Oxidoreductases; Animals; Horses; In Vitro Techniques; Kinetics; Liver; Lysine; Models, Chemical; NAD; Pyridoxal Phosphate; Time Factors | 1975 |
Dogfish M4 lactate dehydrogenase: reversible inactivation by pyridoxal 5'-phosphate and complete protection in complexes that mimic the active ternary complex.
Topics: Animals; Dogfish; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Lysine; NAD; Oxalates; Oxamic Acid; Pyridoxal Phosphate | 1975 |
Purification, characteristics and sequence of a peptide containing an essential lysine residue.
Topics: Amino Acids; Animals; Glutamate Dehydrogenase; Kinetics; Liver; Lysine; Molecular Weight; NAD; Peptide Fragments; Pyridoxal Phosphate; Tuna | 1976 |
Reaction of essential lysyl residues of pig heart diphosphyridine nucleotide dependent isocitrate dehydrogenase with 2,4-pentanedione.
Topics: Animals; Binding Sites; Isocitrate Dehydrogenase; Ketones; Kinetics; Lysine; Myocardium; NAD; Pentanones; Protein Binding; Swine | 1977 |
The reaction of pyruvate with saccharopine dehydrogenase.
Topics: Kinetics; Lysine; Mathematics; NAD; Oxidoreductases Acting on CH-NH Group Donors; Pyruvates; Saccharomyces cerevisiae; Saccharopine Dehydrogenases | 1978 |
Studies on the biosynthesis of cyclitols, XXXVII. On mechanism and function of Schiff's base formation as an intermediary reaction step of myo-inositol-1-phosphate synthase from rat testicles.
Topics: Animals; Binding Sites; Carbohydrate Epimerases; Glucosephosphates; Kinetics; Lysine; Male; Myo-Inositol-1-Phosphate Synthase; NAD; Rats; Schiff Bases; Sugar Alcohols; Testis | 1978 |
Succinic semialdehyde dehydrogenase. Reactivity of lysyl residues.
Topics: Aldehyde Oxidoreductases; Animals; Brain; Kinetics; Lysine; Molecular Weight; NAD; o-Phthalaldehyde; Pyridoxal Phosphate; Succinates; Swine | 1979 |
ADP ribosylation of rat liver lysine-rich histone in vitro.
Topics: Adenosine Diphosphate Sugars; Amino Acids; Animals; Cell Nucleus; Chymotrypsin; Histones; Kinetics; Liver; Lysine; NAD; Nucleoside Diphosphate Sugars; Peptide Fragments; Rats | 1979 |
Reversible inactivation of rat brain pyruvate dehydrogenase multienzyme complex by pyridoxal 5'-phosphate.
Topics: Animals; Brain; Coenzyme A; Enzyme Reactivators; Kinetics; Lysine; Male; NAD; Pyridoxal Phosphate; Pyruvate Dehydrogenase Complex; Rats | 1979 |
Cyanate modification of essential lysyl residues of the diphosphopyridine nucleotide-specific isocitrate dehydrogenase of pig heart.
Topics: Adenosine Diphosphate; Animals; Binding Sites; Cyanates; Edetic Acid; Hydrogen-Ion Concentration; Isocitrate Dehydrogenase; Isocitrates; Kinetics; Lysine; Mathematics; Myocardium; NAD; Oxidation-Reduction; Protein Binding; Swine; Time Factors | 1975 |
Evidence for an essential lysine in glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides.
Topics: Binding Sites; Dinitrophenols; Glucosephosphate Dehydrogenase; Kinetics; Leuconostoc; Lysine; Mathematics; NAD; NADP; Protein Binding; Pyridoxal Phosphate; Spectrophotometry, Ultraviolet; Time Factors | 1975 |
Pathways and regulation of glutamate synthesis in a Corynebacterium sp. overproducing glutamate.
Topics: Ammonium Sulfate; Cell-Free System; Corynebacterium; Glutamate Dehydrogenase; Glutamate Synthase; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Ketoglutaric Acids; Lysine; NAD; NADP; Nitrates; Soil Microbiology | 1975 |
Arginine and lysine residues as NADH-binding sites in NADH-nitrate reductase from spinach.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Diacetyl; Humans; Lysine; Molecular Sequence Data; NAD; NADH, NADPH Oxidoreductases; Nitrate Reductase (NADH); Nitrate Reductases; Phenylglyoxal; Plants; Pyridoxal Phosphate; Sequence Homology, Nucleic Acid | 1992 |
Selective determination of L-lysine with L-lysine epsilon-dehydrogenase.
Topics: Amino Acid Oxidoreductases; Animals; Colorimetry; Indicators and Reagents; Kinetics; Lysine; NAD; Rabbits; Spectrophotometry, Ultraviolet | 1990 |
Characterization of the role of lysine 110 of NADH-cytochrome b5 reductase in the binding and oxidation of NADH by site-directed mutagenesis.
Topics: Adenosine Diphosphate Ribose; Amino Acid Sequence; Animals; Base Sequence; Cattle; Cytochrome Reductases; Cytochrome-B(5) Reductase; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Kinetics; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Oligonucleotides; Oxidation-Reduction; Protein Binding; Sequence Homology, Amino Acid | 1992 |
Importance of lysine-286 at the NADP site of glutamate dehydrogenase from Salmonella typhimurium.
Topics: Binding Sites; Escherichia coli; Glutamate Dehydrogenase; Hydrogen-Ion Concentration; Kinetics; Lysine; Mutagenesis, Site-Directed; NAD; NADP; Salmonella typhimurium; Structure-Activity Relationship | 1992 |
Site-specific mutagenesis of the catalytic subunit of cholera toxin: substituting lysine for arginine 7 causes loss of activity.
Topics: Arginine; Cholera Toxin; Cloning, Molecular; DNA Mutational Analysis; Lysine; NAD; Poly(ADP-ribose) Polymerases; Recombinant Proteins; Structure-Activity Relationship | 1991 |
Cleavage of spermidine as the first step in deoxyhypusine synthesis. The role of NAD.
Topics: Animals; Chromatography, Gel; Chromatography, Ion Exchange; Eukaryotic Translation Initiation Factor 5A; Kinetics; Lysine; Male; NAD; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Precursors; Rats; RNA-Binding Proteins; Spermidine; Testis | 1990 |
Characterization and reconstitution of a cell free system for NAD(+)-dependent deoxyhypusine formation on the 18 kDa eIF-4D precursor.
Topics: Animals; Cell Line; Cell-Free System; Eukaryotic Translation Initiation Factor 5A; Lysine; Mice; Molecular Weight; NAD; Neuroblastoma; Peptide Initiation Factors; Protein Precursors; RNA-Binding Proteins | 1990 |
Role of lysine-54 in determining cofactor specificity and binding in human dihydrofolate reductase.
Topics: Amino Acid Sequence; Base Sequence; Humans; Hydrogen-Ion Concentration; Kinetics; Lysine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; NADP; Oligonucleotide Probes; Recombinant Fusion Proteins; Tetrahydrofolate Dehydrogenase | 1990 |
A spectrophotometric assay for meso-diaminopimelate decarboxylase and L-alpha-amino-epsilon-caprolactam hydrolase.
Topics: Azepines; Bacterial Proteins; Caprolactam; Carbon Dioxide; Carboxy-Lyases; Lysine; NAD; Ninhydrin; Oxidation-Reduction; Saccharopine Dehydrogenases; Spectrophotometry, Ultraviolet | 1989 |
Chemical modification of 3 alpha,20 beta-hydroxysteroid dehydrogenase with diethyl pyrocarbonate. Evidence for an essential, highly reactive, lysyl residue.
Topics: Binding Sites; Binding, Competitive; Chemical Phenomena; Chemistry; Diethyl Pyrocarbonate; Formates; Histidine; Hydrogen-Ion Concentration; Hydroxylamines; Hydroxysteroid Dehydrogenases; Lysine; NAD; Progesterone; Protein Conformation; Streptomyces | 1987 |
NAD+ stimulated the spermidine-dependent hypusine formation on the 18 kDa protein in cytosolic lysates derived from NB-15 mouse neuroblastoma cells.
Topics: Animals; Cell Line; Cytosol; Lysine; Mice; Molecular Weight; NAD; Nerve Tissue Proteins; Neuroblastoma; Putrescine; Spermidine; Tritium | 1988 |
NBD-Cl modification of essential residues in mitochondrial nicotinamide nucleotide transhydrogenase from bovine heart.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Cattle; Chemical Phenomena; Chemistry; Cysteine; Kinetics; Lysine; Mitochondria, Heart; NAD; NADH, NADPH Oxidoreductases; NADP; NADP Transhydrogenases; Oxadiazoles; Photochemistry; Spectrometry, Fluorescence; Spectrophotometry; Sulfhydryl Compounds | 1988 |
NADH binding to cytochrome b5 reductase blocks the acetylation of lysine 110.
Topics: Acetylation; Amino Acids; Animals; Binding Sites; Cattle; Chromatography, High Pressure Liquid; Cytochrome b Group; Cytochromes b5; Lysine; NAD; Peptide Mapping | 1988 |
Cell-free synthesis of deoxyhypusine. Separation of protein substrate and enzyme and identification of 1,3-diaminopropane as a product of spermidine cleavage.
Topics: Animals; Cell Line; Cell-Free System; Chromatography, Ion Exchange; Cricetinae; Diamines; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Lysine; NAD; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine | 1988 |
Enzymatic measurement of saccharopine with saccharopine dehydrogenase.
Topics: Animals; Electrophoresis, Paper; Liver; Lysine; Male; NAD; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Inbred Strains; Saccharopine Dehydrogenases | 1985 |
Dihydrodipicolinic acid reductase.
Topics: Amino Acids, Diamino; Binding, Competitive; Chromatography, DEAE-Cellulose; Chromatography, Gel; Escherichia coli; Flavins; Hydrogen-Ion Concentration; Kinetics; Lysine; NAD; NADP; Oxidoreductases; Phthalic Acids; Picolinic Acids; Pimelic Acids; Structure-Activity Relationship; Tritium | 1974 |
Saccharopine dehydrogenase. A kinetic study of coenzyme binding.
Topics: Adenine Nucleotides; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Binding Sites; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Electrophoresis, Paper; Glyceric Acids; Guanine; Hypoxanthines; Kinetics; Lysine; Mathematics; NAD; NADP; Nucleoside Diphosphate Sugars; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Protein Binding; Ribonucleotides; Ribose; Saccharomyces cerevisiae; Ultrafiltration | 1974 |
Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. IV. Saccharopine dehydrogenase.
Topics: Benzoates; Dipeptides; Enzymes; Ketoglutaric Acids; Lysine; NAD; Oxidoreductases; Saccharomyces; Ultracentrifugation | 1966 |
S to N acetyl migration in yeast glyceraldehyde-3-phosphate dehydrogenase.
Topics: Acetates; Adenine Nucleotides; Chemical Phenomena; Chemistry; Glyceraldehyde-3-Phosphate Dehydrogenases; In Vitro Techniques; Lysine; Muscles; NAD; Yeasts | 1966 |
L-Lysine dehydrogenase deficiency in a patient with congenital lysine intolerance.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acid Oxidoreductases; Cysteine; Humans; In Vitro Techniques; Liver; Lysine; NAD | 1966 |
Metabolism of lysine in rat liver.
Topics: Adipates; Animals; Carbon Isotopes; Centrifugation; Chromatography; Dipeptides; Liver; Lysine; Male; Mitochondria; NAD; Rats; Saccharomyces; Sound | 1967 |
The enzymatic significance of S-acetylation and N-acetylation of 3-phosphoglyceraldehyde dehydrogenase.
Topics: Acetates; Animals; Arsenicals; Autoradiography; Carbon Isotopes; Catalysis; Chemical Phenomena; Chemistry; Cyanides; Cysteine; Glyceraldehyde-3-Phosphate Dehydrogenases; Hydrogen-Ion Concentration; Lysine; Muscles; NAD; Nitrophenols; Phenylacetates; Rabbits | 1967 |
Reversible reaction of epsilon-amino groups of cytochrome c with salicylaldehyde to produce cytochrome c polymers.
Topics: Acids; Aldehydes; Alkalies; Animals; Chromatography, Gel; Cytochromes; Dialysis; Ion Exchange; Kinetics; Lysine; Molecular Weight; NAD; Oxidoreductases; Polymers; Rats; Salicylates; Spectrophotometry | 1968 |
Identification and cobamide coenzyme-dependent formation of 3,5-diaminohexanoic acid, an intermediate in lysine fermentation.
Topics: Adenosine Triphosphate; Amino Acids; Caproates; Carbon Isotopes; Cell-Free System; Chloramines; Clostridium; Coenzyme A; Fermentation; Hydrogen-Ion Concentration; Intrinsic Factor; Iontophoresis; Iron; Ketoglutaric Acids; Light; Lysine; NAD; Periodic Acid; Vitamin B 12 | 1968 |
The role of lysyl residues in the structure and reactivity of cytochrome B5 reductase.
Topics: Acetates; Amides; Anhydrides; Animals; Binding Sites; Cattle; Chemical Phenomena; Chemistry; Cytochromes; Drug Stability; Electron Transport; Fluorescence; Kinetics; Liver; Lysine; Microsomes; NAD; Nitrobenzenes; Oxidoreductases; Protein Denaturation; Spectrophotometry; Succinates; Sulfonic Acids; Tryptophan | 1968 |
Factors affecting the cation requirement of a halophilic NADH dehydrogenase.
Topics: Bacteria; Halogens; Lysine; Magnesium; NAD; Oxidoreductases; Peptides; Sodium Chloride; Spermine | 1968 |
Formation and identification of 3-keto-5-aminohexanoic acid, a probable intermediate in lysine fermentation.
Topics: Amino Acids; Autoradiography; Boron; Butyrates; Caproates; Carbon Isotopes; Clostridium; Coenzyme A; Fermentation; Hot Temperature; Iontophoresis; Keto Acids; Ketoglutaric Acids; Ketones; L-Lactate Dehydrogenase; Lysine; NAD; Pyruvates | 1968 |
Nature and mechanisms of oxygenases.
Topics: Amino Acids; Bacteria; Biotransformation; Catalysis; Catechol Oxidase; Chemical Phenomena; Chemistry; Cholesterol; Collagen; Dihydroxyphenylalanine; Flavin-Adenine Dinucleotide; Hydroxyproline; Lysine; NAD; Oxygen; Oxygenases; Phenylalanine; Plants; Prostaglandins; Squalene; Tryptophan Oxygenase; Tyrosine | 1969 |
Possible requirement of adenosine triphosphate for the rejoining of x-ray-induced breaks in the DNA of Ehrlich ascites-tumour cells.
Topics: Adenosine Triphosphate; Animals; Carcinoma, Ehrlich Tumor; Culture Media; Culture Techniques; DNA, Neoplasm; Female; Glucose; Lysine; Mice; NAD; Nitrogen; Oxygen; Radiation Effects; RNA, Neoplasm; Thymidine; Tritium; Uridine | 1970 |
Purification and properties of a NAD-dependent glutamate dehydrogenase from Clostridium SB4.
Topics: Amino Acids; Ammonia; Chromatography, Gel; Clostridium; Crystallization; Drug Stability; Electrophoresis; Glutamate Dehydrogenase; Hydrogen-Ion Concentration; Keto Acids; Ketoglutaric Acids; Kinetics; Liver; Lysine; Molecular Weight; NAD; Ultracentrifugation | 1970 |
A kinetic study of saccharopine dehydrogenase reaction.
Topics: Chemical Phenomena; Chemistry; Ketoglutaric Acids; Kinetics; Lysine; NAD; Oxidoreductases; Saccharomyces | 1970 |
Lactate dehydrogenase. XI. Effects of guanidination upon the properties of the enzyme.
Topics: Animals; Binding Sites; Cattle; Chemical Phenomena; Chemistry; Fluorometry; Guanidines; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Lysine; Mathematics; Methods; NAD; Oxalates; Protein Binding; Urea | 1970 |
The identification of a reactive lysine residue in lobster glyceraldehyde-3-phosphate dehydrogenase.
Topics: Acetates; Amino Acid Sequence; Animals; Carbon Isotopes; Chromatography, Gel; Crustacea; Electrophoresis; Glyceraldehyde-3-Phosphate Dehydrogenases; Hydrogen-Ion Concentration; Lysine; NAD; Swine; Trypsin | 1970 |
Quinone interaction with the respiratory chain-linked NADH dehydrogenase of beef heart mitochondria. II. Duroquinone reductase activity.
Topics: Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Antimycin A; Bile Acids and Salts; Cattle; Chloromercuribenzoates; Chloroquine; Cytochromes; Electron Transport; In Vitro Techniques; Lysine; Mitochondria, Muscle; Myocardium; NAD; Nitriles; Oligomycins; Oxidoreductases; Peptides; Phenanthrolines; Phenylhydrazines; Phospholipases; Pyridines; Quinones; Surface-Active Agents; Ubiquinone | 1971 |
Glyceraldehyde phosphate dehydrogenase of Escherichia coli. Structural and catalytic properties.
Topics: Acetylesterase; Adenine Nucleotides; Amino Acids; Animals; Arginine; Benzoates; Charcoal; Crystallization; Cysteine; Escherichia coli; Formates; Glyceraldehyde-3-Phosphate Dehydrogenases; Guanidines; Hydrogen-Ion Concentration; Iodoacetates; Lysine; Mercaptoethanol; Molecular Weight; Muscles; NAD; Oxidation-Reduction; Peptides; Protein Denaturation; Rabbits; Spectrophotometry; Sulfhydryl Compounds; Sulfides; Trypsin; Tryptophan; Ultracentrifugation; Ultraviolet Rays | 1971 |
Mechanisms of active transport in isolated membrane vesicles. 2. The coupling of reduced phenazine methosulfate to the concentrative uptake of beta-galactosides and amino acids.
Topics: Amino Acids; Amobarbital; Ascorbic Acid; Bacillus megaterium; Bacillus subtilis; Biological Transport, Active; Cell Membrane; Chloromercuribenzoates; Cyanides; Cyclic N-Oxides; Electron Transport; Escherichia coli; Glutamine; Lactose; Lysine; NAD; Oxygen; Phenazines; Proline; Proteus; Pseudomonas; Quinolines; Salmonella typhimurium; Stimulation, Chemical; Sulfuric Acids | 1971 |
Enzymic synthesis of saccharopine- 14 C.
Topics: Adipates; Aldehydes; Amines; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Paper; Crystallization; Glutarates; Ketoglutaric Acids; Lysine; Methods; NAD; Oxidoreductases; Saccharomyces cerevisiae | 1971 |
The effect of pyridoxal phosphate modification on the catalytic and regulatory properties of bovine liver glutamate dehydrogenase.
Topics: Amino Acid Sequence; Animals; Catalysis; Cattle; Enzyme Activation; Glutamate Dehydrogenase; Guanosine Triphosphate; Kinetics; Liver; Lysine; Macromolecular Substances; NAD; Nitrobenzenes; Peptides; Protein Conformation; Pyridoxal Phosphate; Spectrophotometry; Sulfonic Acids | 1972 |
Identification of the sites of modification of bovine liver glutamate dehydrogenase reacted with trinitrobenzenesulfonate.
Topics: Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Cattle; Chemical Phenomena; Chemistry; Chromatography, Gas; Chromatography, Gel; Chromatography, Ion Exchange; Dansyl Compounds; Glutamate Dehydrogenase; Guanosine Triphosphate; Hydantoins; Iodoacetates; Kinetics; Liver; Lysine; NAD; Nitrobenzenes; Peptides; Spectrophotometry; Sulfhydryl Compounds; Sulfides; Sulfonic Acids; Trypsin | 1971 |
Inactivation of lactate dehydrogenase by butanedione.
Topics: Amino Acids; Animals; Arginine; Butanones; Carbon Isotopes; Cattle; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Enzyme Activation; Glyoxylates; Guanidines; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Lysine; NAD; Oxalates; Peptides; Protein Binding; Pyruvates; Spectrometry, Fluorescence; Trypsin; Ultracentrifugation | 1972 |
Saccharopine dehydrogenase. Interaction with substrate analogues.
Topics: Allosteric Regulation; Amino Acids; Binding Sites; Keto Acids; Ketoglutaric Acids; Kinetics; Lysine; NAD; Oxidoreductases; Saccharomyces cerevisiae | 1972 |
The lysines in liver alcohol dehydrogenase. Chemical modification with pyridoxal 5'-phosphate and methyl picolinimidate.
Topics: Adenosine Monophosphate; Alcohol Oxidoreductases; Animals; Binding Sites; Borohydrides; Chemical Phenomena; Chemistry; Horses; Hydrogen-Ion Concentration; Imides; Imidoesters; Kinetics; Liver; Lysine; NAD; Osmolar Concentration; Oxidation-Reduction; Picolinic Acids; Pyridoxal Phosphate; Zinc | 1972 |
Octopine dehydrogenase. Evidence for a single-chain structure.
Topics: Amino Acids; Animals; Binding Sites; Carboxypeptidases; Cyanates; Dansyl Compounds; Dicarboxylic Acids; Electrophoresis, Polyacrylamide Gel; Guanidines; Lysine; Molecular Weight; Muscles; NAD; Ostreidae; Oxidoreductases; Peptides; Protein Conformation; Sodium Dodecyl Sulfate; Sulfhydryl Reagents; Trypsin; Ultracentrifugation | 1972 |
Enzymic determination of L-lysine in biological materials.
Topics: Animals; Heart; Ketoglutaric Acids; Kidney; Liver; Lung; Lysine; Male; NAD; Oxidoreductases; Rats; Saccharomyces cerevisiae; Spectrophotometry | 1972 |
Purification and properties of L-erythro-3,5-diaminohexanoate dehydrogenase from a lysine-fermenting Clostridium.
Topics: Amino Acid Oxidoreductases; Aminocaproates; Ammonium Sulfate; Carbon Isotopes; Chromatography; Chromatography, DEAE-Cellulose; Chromatography, Gel; Clostridium; Deamination; Drug Stability; Electrophoresis, Paper; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Hydrogen-Ion Concentration; Keto Acids; Lysine; Macromolecular Substances; Molecular Weight; NAD; Osmolar Concentration; Oxidation-Reduction; Polyamines; Sodium Dodecyl Sulfate; Species Specificity; Stereoisomerism | 1972 |
Studies of glutamate dehydrogenase. Characterization of histidine residues involved in the activity and association. Photoactivated labelling with pyridoxal 5'-phosphate.
Topics: Adenosine Diphosphate; Amino Acids; Binding Sites; Carbonates; Diphosphates; Enzyme Activation; Glutamate Dehydrogenase; Guanosine Triphosphate; Histidine; Imidazoles; Light; Lysine; NAD; Photochemistry; Protein Binding; Protein Conformation; Pyridoxal Phosphate; Schiff Bases; Spectrophotometry, Ultraviolet; Tritium | 1973 |
Comparative transport activity of intact cells, membrane vesicles, and mesosomes of Bacillus licheniformis.
Topics: Alanine; Amino Acids; Aspartic Acid; Bacillus; Biological Transport, Active; Carbon Isotopes; Cell Fractionation; Cell Membrane; Cell Membrane Permeability; Centrifugation, Density Gradient; Chromatography, Paper; Culture Media; Glutamates; Histidine; Inclusion Bodies; Light; Lysine; NAD; Sodium; Stereoisomerism; Succinates; Vitamin K | 1973 |
Reactive lysine residues in horse liver alcohol dehydrogenase.
Topics: Alcohol Oxidoreductases; Animals; Autoradiography; Binding Sites; Carbon Isotopes; Chromatography; Horses; Liver; Lysine; NAD; Protein Binding | 1973 |
The effect of modifying lysine-126 on the physical, catalytic and regulatory properties of bovine liver glutamate dehydrogenase.
Topics: Adenosine Diphosphate; Amides; Animals; Binding Sites; Carbon Isotopes; Cattle; Chromatography, Gel; Glutamate Dehydrogenase; Guanosine Triphosphate; Hydrogen-Ion Concentration; Iodoacetates; Ketoglutaric Acids; Kinetics; Liver; Lysine; NAD; Protein Binding; Protein Conformation; Pyridoxal Phosphate; Salicylates; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Sulfites; Time Factors; Ultracentrifugation | 1973 |
Effects of deoxyribonucleic acid and histone on the number and length of chains of poly(adenosine diphosphate-ribose).
Topics: Adenosine Diphosphate; Animals; Cattle; Cell Nucleus; Chromatography; Dextrans; DNA; Histones; Liver; Lysine; NAD; Nucleoside Diphosphate Sugars; Nucleotidyltransferases; Oligonucleotides; Phosphoric Diester Hydrolases; Polynucleotides; Rats; Ribose; Structure-Activity Relationship; Sulfuric Acids; Thymus Gland; Tritium | 1973 |
Functional groups of diphosphopyridine nucleotide linked isocitrate dehydrogenase from bovine heart. I. Studies of an active amino group by amidination, arylation, acetylation, and carbamylation.
Topics: Acetates; Acetylation; Amidines; Amines; Animals; Benzenesulfonates; Benzyl Compounds; Binding Sites; Carbamates; Carbon Radioisotopes; Cattle; Chemical Phenomena; Chemistry; Cyanates; Drug Stability; Hydrogen-Ion Concentration; Isocitrate Dehydrogenase; Kinetics; Lysine; Mitochondria, Muscle; Myocardium; NAD; Nitrobenzenes; Potassium; Structure-Activity Relationship | 1974 |
Structure and activity of methylated horse liver alcohol dehydrogenase.
Topics: Alcohol Oxidoreductases; Amino Acids; Animals; Borohydrides; Chemical Phenomena; Chemistry; Chromatography, Gel; Drug Stability; Electrophoresis, Polyacrylamide Gel; Formaldehyde; Horses; Hot Temperature; Liver; Lysine; Methylation; NAD; Optical Rotatory Dispersion; Protein Conformation; Sodium; Sodium Dodecyl Sulfate; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Sulfhydryl Reagents; Ultracentrifugation | 1974 |
Control of transcription in Bacillus brevis by small molecules.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Bacillus; Carbon Radioisotopes; Cyclic AMP; Cyclic GMP; Depression, Chemical; DNA-Directed RNA Polymerases; Glycerol; Lysine; NAD; RNA, Bacterial; Stimulation, Chemical; Transcription, Genetic; Tyrothricin; Uracil; Uracil Nucleotides | 1974 |
Structure-function relationship in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase. Trinitrophenylation of the lysine residues.
Topics: Animals; Apoproteins; Arsenic; Benzenesulfonates; Binding Sites; Chemical Phenomena; Chemistry; Chymotrypsin; Esters; Fluorobenzenes; Glyceraldehyde; Glyceraldehyde-3-Phosphate Dehydrogenases; Hot Temperature; Hydrogen; Kinetics; Lysine; Muscles; NAD; Nitrobenzenes; Organophosphorus Compounds; Phosphoric Acids; Polymers; Protein Conformation; Rabbits; Spectrometry, Fluorescence; Structure-Activity Relationship | 1974 |
Some peculiarities of metabolism of the myocardium under conditions of experimental disturbance of the microcirculation.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Bradycardia; Dextrans; Electrocardiography; Energy Metabolism; Flavin-Adenine Dinucleotide; Glycogen; Lysine; Microcirculation; Mitochondria, Muscle; Molecular Weight; Myocardium; NAD; Oxidative Phosphorylation; Oxygen Consumption; Phosphorus; Phosphorylases; Rabbits; Stimulation, Chemical; Succinates; Vasopressins | 1974 |
Nicotinamide adenine dinucleotide-specific glutamate dehydrogenase of Neurospora. II. Selective chemical reactivity of amino and sulfhydryl groups.
Topics: Amino Acids; Benzoates; Binding Sites; Disulfides; Dithiothreitol; Ethylmaleimide; Glutamate Dehydrogenase; Hydrogen-Ion Concentration; Hydroxymercuribenzoates; Iodoacetates; Iodobenzoates; Kinetics; Lysine; Molecular Weight; NAD; Neurospora; Neurospora crassa; Nitro Compounds; Osmolar Concentration; Protein Binding; Pyridoxal; Spectrophotometry, Ultraviolet; Sulfhydryl Compounds; Thiocyanates; Time Factors | 1974 |
Nicotinamide adenine dinucleotide-specific glutamate dehydrogenase of Neurospora. III. Isolation and sequences of peptides containing selectively labeled lysine and cysteine residues.
Topics: Amino Acid Sequence; Amino Acids; Aminopeptidases; Binding Sites; Borohydrides; Carbon Radioisotopes; Carboxypeptidases; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Chymotrypsin; Cysteine; Electrophoresis, Paper; Ethylmaleimide; Glutamate Dehydrogenase; Leucyl Aminopeptidase; Lysine; NAD; Neurospora; Neurospora crassa; Oxidation-Reduction; Papain; Peptide Fragments; Protein Binding; Pyridoxal Phosphate; Thermolysin; Trypsin | 1974 |
Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. 3. Aminoadipic semialdehyde-glutamate reductase.
Topics: Adipates; Amino Acid Oxidoreductases; Dipeptides; Glutamates; Lysine; NAD; NADP; Saccharomyces | 1966 |
Production of antibodies with specificity toward adenosine, uridine, and ribose 5-phosphates.
Topics: Adenine Nucleotides; Animals; Antibody Formation; Antigen-Antibody Reactions; Binding Sites; Coenzymes; Complement Fixation Tests; Flavin-Adenine Dinucleotide; Glutamates; Guanine Nucleotides; Immunochemistry; Lysine; NAD; NADP; Oxidation-Reduction; Pentosephosphates; Polymers; Rabbits; Ribose; Uracil Nucleotides | 1968 |
The degradation of hydroxy-L-lysine in liver via its phosphate ester.
Topics: Adenosine Triphosphate; Adipates; Aldehydes; Amino Acids; Animals; Esters; Guanine Nucleotides; Liver; Lysine; Male; NAD; NADP; Phosphoric Acids; Pyridoxal Phosphate; Rats; Stereoisomerism | 1970 |
The conversion of L-lysine to saccharopine and alpha-aminoadipate in mouse.
Topics: Adipates; Aldehydes; Amines; Amino Acids; Animals; Carbon Isotopes; Chromatography, Ion Exchange; Dipeptides; In Vitro Techniques; Ketoglutaric Acids; Liver; Lysine; Male; Mice; NAD; NADP; Oxidation-Reduction; Pipecolic Acids; Transaminases | 1971 |
Glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides. Kinetic studies.
Topics: Aldehydes; Chemical Phenomena; Chemistry; Glucosephosphate Dehydrogenase; Hexosephosphates; Hydrogen-Ion Concentration; Isomerism; Kinetics; Leuconostoc; Lysine; NAD; NADP; Picolines; Protein Binding; Pyridoxal Phosphate | 1971 |
Enzyme regulation, lysine pathways and cell wall structures as indicators of major lines of evolution in fungi.
Topics: Ascomycota; Basidiomycota; Biological Evolution; Calcium; Cell Wall; Fungi; Glutamate Dehydrogenase; Isocitrate Dehydrogenase; L-Lactate Dehydrogenase; Lysine; Magnesium; Myxomycetes; NAD; NADP; Pimelic Acids | 1971 |
Bovine liver glutamate dehydrogenase. Equilibria and kinetics of inactivation by pyridoxal.
Topics: Aldehydes; Animals; Cattle; Chemical Phenomena; Chemistry; Glutamate Dehydrogenase; Hydrogen-Ion Concentration; Imines; Kinetics; Liver; Lysine; Mathematics; Models, Biological; Models, Structural; NAD; NADP; Picolines; Protein Binding; Pyridoxal; Pyridoxine; Spectrophotometry | 1971 |
Bovine liver glutamate dehydrogenase. Equilibria and kinetics of imine formation by lysine-97 with pyridoxal 5'-phosphate.
Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Glutamate Dehydrogenase; Hydrogen-Ion Concentration; Imines; Kinetics; Liver; Lysine; Mathematics; Models, Biological; Models, Structural; NAD; NADP; Protein Binding; Pyridoxal Phosphate | 1971 |
Effect of trinitrophenylation of specific lysyl residues on the catalytic, regulatory, and molecular properties of bovine liver glutamate dehydrogenase.
Topics: Adenosine Diphosphate; Allosteric Regulation; Animals; Catalysis; Cattle; Chromatography, Gel; Enzyme Activation; Glutamate Dehydrogenase; Guanosine Triphosphate; Ketoglutaric Acids; Kinetics; Liver; Lysine; Macromolecular Substances; NAD; NADP; Nitrobenzenes; Rats; Spectrophotometry; Sulfonic Acids; Ultracentrifugation | 1971 |
Identification of the lysine and tyrosine peptides labeled by 5'-p-fluorosulfonylbenzoyladenosine in the NADH inhibitory site of glutamate dehydrogenase.
Topics: Adenosine; Affinity Labels; Amino Acids; Animals; Cattle; Glutamate Dehydrogenase; Kinetics; Liver; Lysine; NAD; Oxidation-Reduction; Tyrosine | 1984 |
Lysine and tyrosine in the NADH inhibitory site of bovine liver glutamate dehydrogenase.
Topics: Adenosine; Amino Acids; Animals; Binding Sites; Cattle; Glutamate Dehydrogenase; Kinetics; Liver; Lysine; NAD; Oxidation-Reduction; Protein Binding; Tyrosine | 1981 |
Occurrence of L-lysine epsilon-dehydrogenase in Agrobacterium tumefaciens.
Topics: Amino Acid Oxidoreductases; Hydrogen-Ion Concentration; Lysine; NAD; Rhizobium; Substrate Specificity | 1982 |
The reactions of pyridoxal 5'-phosphate with the M4 and H4 isoenzymes of pig lactate dehydrogenase.
Topics: Animals; Dose-Response Relationship, Drug; Isoenzymes; L-Lactate Dehydrogenase; Lysine; Myocardium; NAD; Pyridoxal Phosphate; Pyruvates; Pyruvic Acid; Spectrophotometry; Sulfhydryl Compounds; Swine | 1982 |
Investigation of the nature of o-phthalaldehyde reaction with octopine dehydrogenase.
Topics: 4-Chloromercuribenzenesulfonate; Amino Acid Oxidoreductases; Arginine; Binding Sites; Cysteine; Dithiothreitol; Enzyme Activation; Kinetics; Lysine; Mercaptoethanol; NAD; o-Phthalaldehyde; Protein Conformation; Pyruvates; Spectrometry, Fluorescence; Spectrophotometry; Substrate Specificity; Valine | 1994 |
Identification of a lysine residue in the NADH-binding site of salicylate hydroxylase from Pseudomonas putida S-1.
Topics: Amino Acid Sequence; Binding Sites; Chymotrypsin; Lysine; Mixed Function Oxygenases; Molecular Sequence Data; NAD; Pseudomonas putida; Pyridoxal Phosphate; Trinitrobenzenesulfonic Acid | 1995 |
A site-directed mutagenesis study at Lys-113 of NAD(P)H:quinone-acceptor oxidoreductase: an involvement of Lys-113 in the binding of the flavin adenine dinucleotide prosthetic group.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Cloning, Molecular; DNA Primers; Escherichia coli; Flavin-Adenine Dinucleotide; Kinetics; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; NAD(P)H Dehydrogenase (Quinone); NADP; Point Mutation; Recombinant Proteins; Vitamin K | 1995 |
Essential lysine residue in glutathione reductase: chemical modification by pyridoxal 5'-phosphate.
Topics: Adenosine Monophosphate; Binding Sites; Borohydrides; Glutathione; Glutathione Reductase; Lysine; NAD; NADP; Pyridoxal Phosphate; Schiff Bases; Spectrometry, Fluorescence; Yeasts | 1995 |
The effect of ion pairs on the thermal stability of D-glyceraldehyde 3-phosphate dehydrogenase from the hyperthermophilic bacterium Thermotoga maritima.
Topics: Amino Acid Sequence; Arginine; Aspartic Acid; Base Sequence; Enzyme Stability; Glutamic Acid; Glyceraldehyde-3-Phosphate Dehydrogenases; Gram-Negative Anaerobic Bacteria; Hot Temperature; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Sequence Alignment | 1994 |
In the thermophilic archaeon Sulfolobus solfataricus a DNA-binding protein is in vitro (Adpribosyl)ated.
Topics: Adenosine Diphosphate Ribose; Amino Acid Sequence; Amino Acids; Animals; Cattle; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; DNA-Binding Proteins; DNA, Bacterial; Glutamic Acid; Histones; Hot Temperature; Lysine; Molecular Sequence Data; Molecular Weight; NAD; Nucleic Acid Denaturation; Peptide Fragments; Sulfolobus | 1995 |
Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase. A model to study human (Oriental type) class 2 aldehyde dehydrogenase.
Topics: Aldehyde Dehydrogenase; Amino Acid Sequence; Animals; Asian People; Base Sequence; Binding Sites; Catalysis; DNA Primers; Glutamates; Glutamic Acid; Humans; Kinetics; Lysine; Mitochondria, Liver; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Oligodeoxyribonucleotides; Rats; Recombinant Proteins; Sequence Homology, Amino Acid | 1994 |
Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.
Topics: Amino Acid Sequence; Base Sequence; Escherichia coli; Female; Gene Expression; Humans; Hydroxyprostaglandin Dehydrogenases; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Placenta; Prostaglandins; Recombinant Proteins; Sequence Homology; Structure-Activity Relationship; Substrate Specificity; Tyrosine | 1994 |
Modulation of the oxidation-reduction potential of the flavin in lipoamide dehydrogenase from Escherichia coli by alteration of a nearby charged residue, K53R.
Topics: Circular Dichroism; Dihydrolipoamide Dehydrogenase; Electrochemistry; Escherichia coli; Flavin-Adenine Dinucleotide; Kinetics; Lysine; NAD; Oxidation-Reduction; Photochemistry; Spectrometry, Fluorescence; Spectrophotometry; Thioctic Acid | 1994 |
Identification of lysine 153 as a functionally important residue in UDP-galactose 4-epimerase from Escherichia coli.
Topics: Binding Sites; Escherichia coli; Kinetics; Lysine; Models, Molecular; Mutagenesis, Site-Directed; NAD; Recombinant Proteins; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; UDPglucose 4-Epimerase; Uridine Monophosphate | 1993 |
Involvement of different cysteines in the inactivation of octopine dehydrogenase by p-chloromercuricphenyl sulfonic acid and o-phthalaldehyde.
Topics: 4-Chloromercuribenzenesulfonate; Amino Acid Oxidoreductases; Binding Sites; Cysteine; Dithiothreitol; Indoles; Lysine; NAD; o-Phthalaldehyde; Spectrometry, Fluorescence | 1993 |
Kinetics of a glycine for Arg-47 human alcohol dehydrogenase mutant can be explained by Lys-228 recruitment into the pyrophosphate binding site.
Topics: Alcohol Dehydrogenase; Arginine; Binding Sites; Diphosphates; Glycine; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Liver; Lysine; Mutagenesis, Site-Directed; NAD | 1993 |
The identification of a lysine residue reactive to pyridoxal-5-phosphate in the glycerol dehydrogenase from the thermophile Bacillus stearothermophilus.
Topics: Amino Acid Sequence; Dose-Response Relationship, Drug; Enzyme Activation; Geobacillus stearothermophilus; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Peptide Fragments; Pyridoxal Phosphate; Sugar Alcohol Dehydrogenases; Trypsin | 1993 |
Role of Lys-110 of human NADH-cytochrome b5 reductase in NADH binding as probed by site-directed mutagenesis.
Topics: Base Sequence; Cytochrome Reductases; Cytochrome-B(5) Reductase; DNA, Single-Stranded; Humans; Kinetics; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD | 1993 |
Dye-affinity labelling of bovine heart mitochondrial malate dehydrogenase and study of the NADH-binding site.
Topics: Affinity Labels; Animals; Anthraquinones; Binding Sites; Cattle; Coloring Agents; In Vitro Techniques; Kinetics; Lysine; Malate Dehydrogenase; Mitochondria, Heart; Models, Molecular; Molecular Structure; NAD; Protein Conformation; Triazines | 1996 |
Identification of cysteine and lysine residues present at the active site of beef liver glutamate dehydrogenase by o-phthalaldehyde.
Topics: 4-Chloromercuribenzenesulfonate; Animals; Binding Sites; Cattle; Cysteine; Enzyme Inhibitors; Glutamate Dehydrogenase; Indoles; Ketoglutaric Acids; Kinetics; Liver; Lysine; Mercaptoethanol; Models, Chemical; NAD; o-Phthalaldehyde; Spectrometry, Fluorescence | 1996 |
Construction and characterization of a deletion mutant of gpd2 that encodes an isozyme of NADH-dependent glycerol-3-phosphate dehydrogenase in fission yeast.
Topics: DNA, Fungal; Gene Expression Regulation, Enzymologic; Glycerol; Glycerolphosphate Dehydrogenase; Histidine; Isoenzymes; Lysine; Mutation; NAD; Osmolar Concentration; Phenotype; Schizosaccharomyces | 1996 |
Amplified determination of lipoyl groups by lipoamide dehydrogenase in the presence of oxidized glutathione.
Topics: Dihydrolipoamide Dehydrogenase; Disulfides; Glutathione; Glutathione Disulfide; Kinetics; Lysine; NAD; Oxidation-Reduction; Substrate Specificity; Thioctic Acid | 1996 |
Reactivity of essential cysteine and lysine residues present at the catalytic domain of pig heart mitochondrial malate dehydrogenase.
Topics: Animals; Binding Sites; Cysteine; Dithionitrobenzoic Acid; Enzyme Inhibitors; Hydrogen-Ion Concentration; Kinetics; Lysine; Malate Dehydrogenase; Mitochondria, Heart; NAD; o-Phthalaldehyde; Pyridoxal Phosphate; Swine | 1995 |
Photoaffinity labelling of human poly(ADP-ribose) polymerase catalytic domain.
Topics: Affinity Labels; Amino Acid Sequence; Azides; Binding Sites; DNA Mutational Analysis; Humans; Light; Lysine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Peptide Fragments; Photochemistry; Poly(ADP-ribose) Polymerases; Recombinant Proteins; Sequence Analysis; Tryptophan | 1997 |
Essential active-site lysine of brain glutamate dehydrogenase isoproteins.
Topics: Animals; Binding Sites; Brain; Brain Chemistry; Cattle; Chromatography, High Pressure Liquid; Enzyme Activation; Glutamate Dehydrogenase; Humans; Isoenzymes; Ketoglutaric Acids; Lysine; NAD; Peptides; Protein Processing, Post-Translational; Pyridoxal Phosphate | 1997 |
The potential roles of the conserved amino acids in human liver mitochondrial aldehyde dehydrogenase.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Amino Acid Sequence; Amino Acids; Animals; Cattle; Conserved Sequence; Glutamine; Humans; Kinetics; Lysine; Mitochondria, Liver; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Sequence Alignment | 1997 |
Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes.
Topics: 2-Aminoadipic Acid; Bacterial Proteins; Cephamycins; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Kinetics; L-Lysine 6-Transaminase; Lysine; Molecular Weight; NAD; Oxidoreductases Acting on CH-NH Group Donors; Picolinic Acids; Pipecolic Acids; Piperidines; Pyrroles; Quaternary Ammonium Compounds; Streptomyces; Substrate Specificity; Transaminases | 1997 |
Intersubunit communication in hybrid hexamers of K89L/A163G/S380A and C320S mutants of glutamate dehydrogenase from Clostridium symbiosum.
Topics: Alanine; Allosteric Regulation; Clostridium; Dithionitrobenzoic Acid; Glutamate Dehydrogenase; Glutamic Acid; Lysine; NAD; Protein Conformation; Protein Denaturation; Protein Folding; Recombinant Proteins; Serine | 1997 |
Crystal structure of a non-toxic mutant of heat-labile enterotoxin, which is a potent mucosal adjuvant.
Topics: Adjuvants, Immunologic; Bacterial Toxins; Bacterial Vaccines; Binding Sites; Crystallization; Crystallography, X-Ray; Enterotoxins; Escherichia coli Proteins; Lysine; Models, Molecular; Molecular Structure; Mucous Membrane; Mutagenesis; NAD; Protein Conformation; Protein Engineering; Serine; Structure-Activity Relationship | 1997 |
Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site.
Topics: Binding Sites; Crystallography, X-Ray; Humans; Hydrogen Bonding; Lysine; Models, Molecular; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Conformation; Protein Processing, Post-Translational; Protein Structure, Secondary; Recombinant Proteins; Spermidine | 1998 |
Assay of protein-bound lipoic acid in tissues by a new enzymatic method.
Topics: Animals; Cattle; Dihydrolipoamide Dehydrogenase; Glutathione Disulfide; Lysine; NAD; Oxidation-Reduction; Protein Binding; Proteins; Rabbits; Rats; Thioctic Acid | 1998 |
Site-directed mutagenesis of human dihydrolipoamide dehydrogenase: role of lysine-54 and glutamate-192 in stabilizing the thiolate-FAD intermediate.
Topics: Base Sequence; Circular Dichroism; Dihydrolipoamide Dehydrogenase; DNA Primers; Electron Transport; Enzyme Stability; Escherichia coli; Flavin-Adenine Dinucleotide; Genetic Vectors; Glutamic Acid; Humans; In Vitro Techniques; Kinetics; Lysine; Models, Molecular; Mutagenesis, Site-Directed; NAD; Protein Conformation; Recombinant Proteins; Spectrometry, Fluorescence | 1999 |
Control of coenzyme binding to horse liver alcohol dehydrogenase.
Topics: Alcohol Dehydrogenase; Animals; Arginine; Coenzymes; Computer Simulation; Glutamine; Histidine; Horses; Hydrogen-Ion Concentration; Kinetics; Liver; Lysine; Mutagenesis, Site-Directed; NAD; Protein Binding | 1999 |
Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis.
Topics: Amino Acid Substitution; Bacterial Proteins; Binding Sites; Catalysis; Circular Dichroism; Deuterium; Histidine; Kinetics; Lysine; Mutagenesis, Site-Directed; Mycobacterium tuberculosis; NAD; Oxidoreductases; Peptide Fragments; Recombinant Proteins; Solvents; Tyrosine | 1999 |
Lysine 219 participates in NADPH specificity in a flavin-containing monooxygenase from Saccharomyces cerevisiae.
Topics: Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Cysteine; Escherichia coli; Flavin-Adenine Dinucleotide; Kinetics; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; NADP; Oxidation-Reduction; Oxygenases; Phosphates; Recombinant Proteins; Saccharomyces cerevisiae; Sequence Alignment; Substrate Specificity | 1999 |
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.
Topics: Acetylation; Adenosine Diphosphate Ribose; Animals; Chickens; Fungal Proteins; Gene Silencing; Histone Deacetylases; Histones; Lysine; Multigene Family; NAD; Niacinamide; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Trans-Activators | 2000 |
Overexpression of salicylate hydroxylase and the crucial role of lys(163) as its NADH binding site.
Topics: Amino Acid Substitution; Apoenzymes; Binding Sites; Cell-Free System; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Hydrogen-Ion Concentration; Inclusion Bodies; Kinetics; Lysine; Mixed Function Oxygenases; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Pseudomonas putida | 2000 |
Lysine 199 is the general acid in the NAD-malic enzyme reaction.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Ascaris suum; Catalysis; Conserved Sequence; Hydrogen-Ion Concentration; Kinetics; Lysine; Malate Dehydrogenase; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Oxaloacetic Acid; Pyruvic Acid; Solvents; Tritium | 2000 |
Basis for half-of-the-site reactivity and the dominance of the K487 oriental subunit over the E487 subunit in heterotetrameric human liver mitochondrial aldehyde dehydrogenase.
Topics: Aldehyde Dehydrogenase; Amino Acid Substitution; Asian People; Binding Sites; Dimerization; Enzyme Activation; Glutamic Acid; Humans; Kinetics; Lysine; Mitochondria, Liver; Mutagenesis, Site-Directed; NAD; Peptide Fragments | 2000 |
A positively charged cluster formed in the heme-distal pocket of cytochrome P450nor is essential for interaction with NADH.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Bromides; Camphor 5-Monooxygenase; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Heme; Kinetics; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Nitric Oxide; Oxidoreductases; Phosphates; Protein Structure, Secondary; Sequence Homology, Amino Acid; Spectrophotometry | 2001 |
Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates.
Topics: Binding Sites; Eukaryotic Initiation Factor-5; Humans; Hydrogen-Ion Concentration; Lysine; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Binding; Protein Precursors; Spermidine; Substrate Specificity; Time Factors | 2000 |
Delineation of the roles of amino acids involved in the catalytic functions of Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase.
Topics: Arginine; Binding Sites; Catalysis; Conserved Sequence; Dimerization; Glucose-6-Phosphate; Glucosephosphate Dehydrogenase; Glutamine; Kinetics; Leuconostoc; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Mutation; NAD; NADP; Proline; Thermodynamics | 2000 |
Mechanisms of inactivation of human S-adenosylhomocysteine hydrolase by 5',5',6',6'-tetradehydro-6'-deoxy-6'-halohomoadenosines.
Topics: Adenine; Adenosylhomocysteinase; Chlorides; Deoxyadenosines; Enzyme Inhibitors; Halogens; Humans; Hydrolases; Lysine; Models, Molecular; NAD; Peptide Mapping; S-Adenosylhomocysteine; Spectrometry, Mass, Fast Atom Bombardment | 2000 |
Coenzyme specificity of human monomeric carbonyl reductase: contribution of Lys-15, Ala-37 and Arg-38.
Topics: Alanine; Alcohol Oxidoreductases; Arginine; Binding Sites; Coenzymes; Escherichia coli; Humans; In Vitro Techniques; Kinetics; Lysine; Mutagenesis, Site-Directed; NAD; NADP; Recombinant Proteins | 2001 |
The A245K mutation exposes another stage of the bacterial L-lactate dehydrogenase reaction mechanism.
Topics: Alanine; Binding Sites; Catalysis; Computer Simulation; Electron Transport; Geobacillus stearothermophilus; Kinetics; L-Lactate Dehydrogenase; Lysine; Models, Chemical; Mutagenesis, Site-Directed; NAD; Protein Conformation; Solvents; Substrate Specificity; Viscosity | 2001 |
Mechanistic roles of Thr134, Tyr160, and Lys 164 in the reaction catalyzed by dTDP-glucose 4,6-dehydratase.
Topics: Catalytic Domain; Circular Dichroism; Escherichia coli; Glucose; Hydro-Lyases; Hydrogen-Ion Concentration; Kinetics; Lysine; Mutagenesis, Site-Directed; NAD; Phosphotransferases (Phosphomutases); Threonine; Thymine Nucleotides; Tyrosine; UDPglucose 4-Epimerase; Xylose | 2001 |
Assimilatory nitrate reductase: lysine 741 participates in pyridine nucleotide binding via charge complementarity.
Topics: Amino Acid Sequence; Amino Acid Substitution; Circular Dichroism; Flavin-Adenine Dinucleotide; Hydrogen-Ion Concentration; Kinetics; Lysine; Molecular Sequence Data; Mutation; NAD; NADH, NADPH Oxidoreductases; Nitrate Reductase; Nitrate Reductases; Protein Structure, Tertiary; Pyridines; Sequence Alignment; Spectrometry, Fluorescence; Spectrum Analysis; Spinacia oleracea; Static Electricity | 2001 |
The structure and biochemistry of NADH-dependent cytochrome b5 reductase are now consistent.
Topics: Amino Acid Sequence; Animals; Crystallization; Crystallography, X-Ray; Cytochrome Reductases; Cytochrome-B(5) Reductase; Humans; Lysine; Methemoglobinemia; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Protein Conformation; Rats; Sequence Homology, Amino Acid; Swine | 2001 |
Identification of tissue transglutaminase-reactive lysine residues in glyceraldehyde-3-phosphate dehydrogenase.
Topics: Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Glutamine; Glyceraldehyde-3-Phosphate Dehydrogenases; Lysine; Mass Spectrometry; Microscopy, Fluorescence; Models, Molecular; NAD; Peptides; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Rabbits; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Swine; Time Factors; Transglutaminases | 2002 |
Effect of addition of proton carriers in culture medium on growth and secretion of hybridoma cell line OKT3.
Topics: Algorithms; Animals; Cell Division; Cell Line; Chromatography, High Pressure Liquid; Culture Media; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Hybridomas; Lysine; Mice; Muromonab-CD3; NAD; Protons; Spectrophotometry, Ultraviolet; Stimulation, Chemical | 2001 |
Catalytic mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.
Topics: Adenosylhomocysteinase; Animals; Apoenzymes; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Cattle; Circular Dichroism; Crystallography, X-Ray; DNA, Complementary; Escherichia coli; Holoenzymes; Hydrolases; Hydrolysis; Kinetics; Liver; Lysine; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; NAD; NADP; Protein Binding; Rats; Time Factors; Ultraviolet Rays | 2002 |
Domain closure, substrate specificity and catalysis of D-lactate dehydrogenase from Lactobacillus bulgaricus.
Topics: Binding Sites; Catalysis; Dimerization; Enzyme Activation; Escherichia coli; Kinetics; L-Lactate Dehydrogenase; Lactate Dehydrogenases; Lactobacillus; Lysine; Models, Molecular; Mutation; NAD; Protein Conformation; Protons; Pyruvates; Recombinant Proteins; Rotation; Sensitivity and Specificity; Solutions; Substrate Specificity; Sulfates | 2002 |
Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine.
Topics: Acetate-CoA Ligase; Acetylation; Acyl Coenzyme A; Adenosine Monophosphate; Amino Acid Motifs; Amino Acid Sequence; Bacterial Proteins; Binding Sites; Coenzyme A; Conserved Sequence; Enzyme Activation; Gene Expression Regulation, Bacterial; Immunoblotting; Lysine; Mass Spectrometry; NAD; Peptide Mapping; Salmonella enterica; Sirtuins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2002 |
Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex.
Topics: Acetylation; Animals; Catalysis; Drosophila; Histones; Lysine; Molecular Sequence Data; NAD; Nucleoproteins; Recombinant Proteins; Sirtuins; Transcription, Genetic | 2003 |
The catalytic mechanism of Drosophila alcohol dehydrogenase: evidence for a proton relay modulated by the coupled ionization of the active site Lysine/Tyrosine pair and a NAD+ ribose OH switch.
Topics: Alcohol Dehydrogenase; Animals; Binding Sites; Catalysis; Computer Simulation; Drosophila; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydroxides; Lysine; Models, Chemical; Models, Molecular; NAD; Oxidation-Reduction; Protein Binding; Protons; Substrate Specificity; Tyrosine; Water | 2003 |
Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase.
Topics: Eukaryotic Translation Initiation Factor 5A; Humans; Hydrogen-Ion Concentration; Kinetics; Lysine; Models, Chemical; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Putrescine; RNA-Binding Proteins; Spermidine; Time Factors; Trichloroacetic Acid | 2003 |
Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry.
Topics: Acetylation; Adenosine Diphosphate Ribose; Animals; Archaeoglobus fulgidus; Base Pairing; Gene Expression Regulation, Fungal; Histone Deacetylases; Lysine; Mice; Models, Biological; NAD; Niacinamide; Oxygen; Peptide Fragments; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 1; Sirtuin 2; Sirtuins; Species Specificity | 2003 |
A GENERALIZED PATHWAY FOR LEUCINE AND LYSINE BIOSYNTHESIS.
Topics: Adenosine Triphosphate; Carbon Isotopes; Coenzyme A; Leucine; Lysine; NAD; Proteins; Research; Saccharomyces | 1964 |
NONCOVALENT INTERACTIONS BETWEEN AMINO ACID SIDE CHAINS AND A COENZYME MODEL.
Topics: Amino Acids; Coenzymes; Fluorescence; Fluorometry; Histidine; Imidazoles; Indoles; Lysine; Methionine; NAD; Phenols; Phenylalanine; Pyridines; Research; Spectrum Analysis; Tyramine; Tyrosine | 1964 |
AMINO ACIDS AS SUBSTRATE FOR THE REDUCTION OF TELLURITE BY CELLS OF PROTEUS VULGARIS.
Topics: Amino Acids; Cyanides; Enzyme Inhibitors; Flavin-Adenine Dinucleotide; Glutamates; Glycine; Hydrogen-Ion Concentration; Leucine; Lysine; Methionine; NAD; Nitrogen; Ornithine; Oxidation-Reduction; Oxidoreductases; Pharmacology; Proteus; Proteus vulgaris; Research; Tellurium | 1965 |
Structural basis for the mechanism and regulation of Sir2 enzymes.
Topics: Adenosine Diphosphate Ribose; Amino Acid Sequence; Archaea; Archaeal Proteins; Catalytic Domain; Lysine; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; NAD; Protein Binding; Sequence Homology, Amino Acid; Sirtuins; Structure-Activity Relationship | 2004 |
The ND1 gene of complex I is a mutational hot spot for Leber's hereditary optic neuropathy.
Topics: Adult; Aged; DNA Mutational Analysis; DNA, Mitochondrial; Family Health; Female; Ferricyanides; Glutamic Acid; Haplotypes; Humans; Inhibitory Concentration 50; Lysine; Magnetic Resonance Spectroscopy; Male; Microscopy, Electron, Transmission; Middle Aged; Mitochondria, Muscle; Models, Molecular; Muscle, Skeletal; Mutation; NAD; NADH Dehydrogenase; Occipital Lobe; Optic Atrophy, Hereditary, Leber; Pedigree; Polymorphism, Restriction Fragment Length; Radionuclide Imaging; Rotenone; Sequence Analysis, Protein; Succinate Dehydrogenase; Visual Acuity; Visual Fields | 2004 |
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Blotting, Western; Cell Differentiation; Cell Line; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Liquid; E1A-Associated p300 Protein; Fibroblasts; Genes, Reporter; Genetic Vectors; Histone Deacetylases; Humans; Immunoprecipitation; Luciferases; Lysine; Mass Spectrometry; Mice; Molecular Sequence Data; NAD; NF-kappa B; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Oligonucleotides; Peptides; Protein Binding; Protein Structure, Tertiary; Retroviridae; RNA; Serine Endopeptidases; Sirtuin 1; Sirtuins; Time Factors; Trans-Activators; Transcriptional Activation; Tumor Suppressor Protein p53; Ubiquitin | 2005 |
Fine tuning of coenzyme specificity in family 2 aldo-keto reductases revealed by crystal structures of the Lys-274-->Arg mutant of Candida tenuis xylose reductase (AKR2B5) bound to NAD+ and NADP+.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Arginine; Candida; Coenzymes; Crystallography, X-Ray; Kinetics; Lysine; NAD; NADP; Protein Conformation | 2005 |
Crystal structure of a novel shikimate dehydrogenase from Haemophilus influenzae.
Topics: Alcohol Oxidoreductases; Asparagine; Bayes Theorem; Catalysis; Circular Dichroism; Cloning, Molecular; Crystallography, X-Ray; Haemophilus influenzae; Herbicides; Hydrogen-Ion Concentration; Ions; Kinetics; Lysine; Models, Molecular; Mutagenesis; Mutagenesis, Site-Directed; NAD; NADP; Oxygen; Phylogeny; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Substrate Specificity; Temperature | 2005 |
A catalytic triad is responsible for acid-base chemistry in the Ascaris suum NAD-malic enzyme.
Topics: Animals; Arginine; Ascaris suum; Aspartic Acid; Catalytic Domain; Deuterium Exchange Measurement; Hydrogen-Ion Concentration; Kinetics; Lysine; Malate Dehydrogenase; Models, Chemical; NAD; Phenylalanine; Spectrophotometry; Substrate Specificity; Tyrosine | 2005 |
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
Topics: Acetylation; Animals; Caloric Restriction; Cyclic AMP; Fasting; Gene Expression Regulation; Gluconeogenesis; Glucose; Glycolysis; Hepatocytes; Homeostasis; Insulin; Lactic Acid; Liver; Longevity; Lysine; Mice; NAD; Nutritional Status; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Protein Binding; Pyruvic Acid; Rats; RNA, Messenger; Sirtuin 1; Sirtuins; Trans-Activators; Transcription Factors | 2005 |
Aspartate 120 of Escherichia coli methylenetetrahydrofolate reductase: evidence for major roles in folate binding and catalysis and a minor role in flavin reactivity.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Alanine; Asparagine; Aspartic Acid; Catalysis; Cold Temperature; Escherichia coli Proteins; Flavin-Adenine Dinucleotide; Folic Acid; Imines; Kinetics; Lysine; Mutagenesis, Site-Directed; NAD; Oxidation-Reduction; Potentiometry; Spectrophotometry; Substrate Specificity; Thermodynamics | 2005 |
Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-dependent histone deacetylation.
Topics: Binding Sites; Histone Deacetylases; Histones; Lysine; Macromolecular Substances; NAD; O-Acetyl-ADP-Ribose; Phosphoglycerate Dehydrogenase; Protein Binding; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins | 2005 |
Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant.
Topics: Aldehyde Dehydrogenase; Arginine; Binding Sites; Crystallography, X-Ray; Dimerization; DNA, Complementary; Glutamic Acid; Humans; Hydrogen Bonding; Kinetics; Lysine; Mitochondria; Models, Molecular; NAD; Protein Binding; Protein Conformation; Protein Structure, Tertiary | 2005 |
SIRT1 top 40 hits: use of one-bead, one-compound acetyl-peptide libraries and quantum dots to probe deacetylase specificity.
Topics: Acetylation; Amino Acids; Biotin; Catalysis; Histone Deacetylases; Humans; Lysine; Mass Spectrometry; NAD; Peptide Library; Quantum Dots; Reproducibility of Results; Sensitivity and Specificity; Sirtuin 1; Sirtuins; Spectrometry, Fluorescence; Streptavidin; Substrate Specificity | 2006 |
Use of substrate analogs and mutagenesis to study substrate binding and catalysis in the Sir2 family of NAD-dependent protein deacetylases.
Topics: Acetylation; Amino Acid Sequence; Binding Sites; Catalysis; Histone Deacetylases; Kinetics; Lysine; Molecular Sequence Data; Mutagenesis; NAD; O-Acetyl-ADP-Ribose; Point Mutation; Protein Binding; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Substrate Specificity | 2006 |
Lys-D48 is required for charge stabilization, rapid flavin reduction, and internal electron transfer in the catalytic cycle of dihydroorotate dehydrogenase B of Lactococcus lactis.
Topics: Catalysis; Dihydroorotate Dehydrogenase; Dimerization; Electrochemistry; Electron Transport; Flavin Mononucleotide; Flavins; Lactococcus lactis; Lysine; Mutagenesis, Site-Directed; NAD; Orotic Acid; Oxidation-Reduction; Oxidoreductases Acting on CH-CH Group Donors; Protein Structure, Tertiary; Tyrosine | 2006 |
Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.
Topics: Binding Sites; Enzyme Inhibitors; Hydrogen-Ion Concentration; Kinetics; Lysine; NAD; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Saccharopine Dehydrogenases | 2006 |
Sir2 deacetylases exhibit nucleophilic participation of acetyl-lysine in NAD+ cleavage.
Topics: Hydrolysis; Kinetics; Lysine; NAD; Sirtuins | 2007 |
N-lysine propionylation controls the activity of propionyl-CoA synthetase.
Topics: Binding Sites; Coenzyme A Ligases; Humans; Lysine; Mitochondrial Proteins; Molecular Conformation; NAD; Nicotinamidase; Peptides; Salmonella enterica; Sirtuin 1; Sirtuin 2; Sirtuin 3; Sirtuins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors | 2007 |
Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity.
Topics: ADP Ribose Transferases; Amino Acid Sequence; Animals; Genetic Complementation Test; Histone Deacetylases; Lysine; Models, Biological; Molecular Sequence Data; Mutation; NAD; Niacinamide; Plasmodium falciparum; Protozoan Proteins; Recombinant Proteins; Schizosaccharomyces pombe Proteins; Sequence Alignment; Sirtuins | 2007 |
Structural studies of the final enzyme in the alpha-aminoadipate pathway-saccharopine dehydrogenase from Saccharomyces cerevisiae.
Topics: Alanine Dehydrogenase; Amino Acid Sequence; Binding Sites; Catalysis; Crystallography, X-Ray; Lysine; Models, Molecular; Molecular Sequence Data; NAD; Protein Conformation; Saccharomyces cerevisiae; Saccharopine Dehydrogenases; Sequence Homology, Amino Acid | 2007 |
Molecular clip and tweezer introduce new mechanisms of enzyme inhibition.
Topics: Alcohol Dehydrogenase; Circular Dichroism; Enzyme Inhibitors; Kinetics; Lysine; Molecular Conformation; NAD; Organophosphates; Polycyclic Aromatic Hydrocarbons | 2008 |
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control.
Topics: Acetylation; Animals; ARNTL Transcription Factors; Basic Helix-Loop-Helix Transcription Factors; Chromatin Assembly and Disassembly; Circadian Rhythm; CLOCK Proteins; DNA-Binding Proteins; Embryo, Mammalian; Gene Expression; Histones; Liver; Lysine; Mice; Mice, Inbred BALB C; NAD; Promoter Regions, Genetic; Sirtuin 1; Sirtuins; Trans-Activators; Transcription Factors | 2008 |
Plasmodium falciparum Sir2 is an NAD+-dependent deacetylase and an acetyllysine-dependent and acetyllysine-independent NAD+ glycohydrolase.
Topics: Acetylation; Animals; Histones; Hydrolysis; Lysine; NAD; NAD+ Nucleosidase; Peptides; Plasmodium falciparum; Protozoan Proteins; Sirtuins | 2008 |
[Mutational research on the role of lysine 21 in the Pichia stipitis xylose reductase].
Topics: Aldehyde Reductase; Amino Acid Substitution; Coenzymes; Escherichia coli; Ethanol; Lysine; Mutagenesis, Site-Directed; NAD; NADP; Pichia; Recombinant Proteins; Recombination, Genetic; Xylose | 2008 |
Defective myotilin homodimerization caused by a novel mutation in MYOT exon 9 in the first Japanese limb girdle muscular dystrophy 1A patient.
Topics: Actinin; Animals; Arginine; Chlorocebus aethiops; Connectin; COS Cells; Cytoskeletal Proteins; DNA Mutational Analysis; Exons; Female; Humans; Immunoprecipitation; Japan; Lysine; Male; Microfilament Proteins; Middle Aged; Molecular Sequence Data; Muscle Proteins; Muscular Dystrophies, Limb-Girdle; Mutation, Missense; NAD; Protein Structure, Tertiary; Serine; Transfection; Two-Hybrid System Techniques | 2009 |
Reconstitution of heterochromatin-dependent transcriptional gene silencing.
Topics: Acetylation; Adenosine Triphosphatases; Cell Cycle Proteins; Chromatin Assembly and Disassembly; DNA Restriction Enzymes; DNA-Binding Proteins; Gene Expression Regulation, Fungal; Gene Silencing; Heterochromatin; Histone Deacetylases; Histones; Lysine; Multiprotein Complexes; Mutation; NAD; Nuclear Proteins; Nucleosome Assembly Protein 1; Protein Binding; RNA Polymerase II; RNA Polymerase III; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Transcription, Genetic | 2009 |
Contributions of active site residues to cofactor binding and catalysis of 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase.
Topics: Androsterone; Asparagine; Catalysis; Catalytic Domain; Fluorescence Polarization; Hydroxysteroid Dehydrogenases; Kinetics; Lysine; Mutation; NAD; Protein Binding; Tyrosine | 2010 |
First crystal structure of L-lysine 6-dehydrogenase as an NAD-dependent amine dehydrogenase.
Topics: Amino Acid Sequence; Catalysis; Catalytic Domain; Coenzymes; Crystallography, X-Ray; Hot Temperature; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Oxidoreductases; Protein Structure, Quaternary; Protein Structure, Secondary; Pyrococcus horikoshii; Recombinant Proteins; Saccharopine Dehydrogenases | 2010 |
Glutamates 78 and 122 in the active site of saccharopine dehydrogenase contribute to reactant binding and modulate the basicity of the acid-base catalysts.
Topics: Acid-Base Equilibrium; Alanine; Amino Acid Substitution; Binding, Competitive; Catalysis; Catalytic Domain; Glutamic Acid; Glutamine; Kinetics; Lysine; Models, Molecular; Mutagenesis, Site-Directed; NAD; Recombinant Proteins; Saccharomyces cerevisiae; Saccharopine Dehydrogenases | 2010 |
Transition state of ADP-ribosylation of acetyllysine catalyzed by Archaeoglobus fulgidus Sir2 determined by kinetic isotope effects and computational approaches.
Topics: Acetylation; Adenosine Diphosphate Ribose; Archaeoglobus fulgidus; Biocatalysis; Computer Simulation; Kinetics; Lysine; NAD; Sirtuin 2 | 2010 |
Lysine deacetylation in ischaemic preconditioning: the role of SIRT1.
Topics: Acetylation; Animals; Disease Models, Animal; Ischemic Preconditioning, Myocardial; Lysine; Male; Mice; Mice, Inbred C57BL; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; NAD; Sirtuin 1 | 2011 |
The oxidation state of active site thiols determines activity of saccharopine dehydrogenase at low pH.
Topics: Amino Acid Substitution; Apoenzymes; Base Sequence; Catalytic Domain; Cysteine; Deuterium Exchange Measurement; DNA, Fungal; Hydrogen-Ion Concentration; Kinetics; Lysine; Models, Molecular; Mutagenesis, Site-Directed; NAD; Oxidation-Reduction; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Saccharopine Dehydrogenases; Sulfhydryl Compounds | 2011 |
Contribution of K99 and D319 to substrate binding and catalysis in the saccharopine dehydrogenase reaction.
Topics: Imines; Ketoglutaric Acids; Lysine; Models, Molecular; NAD; Point Mutation; Protein Binding; Saccharomyces cerevisiae; Saccharopine Dehydrogenases; Substrate Specificity | 2011 |
Structure of the membrane domain of respiratory complex I.
Topics: Antiporters; Cell Membrane; Crystallography, X-Ray; Electron Transport Complex I; Escherichia coli; Escherichia coli Proteins; Ion Transport; Lysine; Models, Molecular; NAD; NADH Dehydrogenase; Protein Binding; Protein Folding; Protein Structure, Tertiary; Protein Subunits; Protons; Ubiquinone | 2011 |
SIRT1-mediated acute cardioprotection.
Topics: Acetylation; Animals; Animals, Genetically Modified; Blotting, Western; Cytosol; Forkhead Box Protein O1; Forkhead Transcription Factors; Heart; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Lysine; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Reperfusion Injury; NAD; Signal Transduction; Sirtuin 1; Superoxide Dismutase | 2011 |
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
Topics: Acetylation; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Cattle; Crystallography, X-Ray; Histones; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Kinetics; Lysine; Male; Mice; Mice, Knockout; Mitochondria, Liver; NAD; Peptides; Protein Processing, Post-Translational; Sirtuins; Succinic Acid | 2011 |
Nondegradative ubiquitination of apoptosis inducing factor (AIF) by X-linked inhibitor of apoptosis at a residue critical for AIF-mediated chromatin degradation.
Topics: Amino Acid Substitution; Apoptosis Inducing Factor; Binding Sites; Cell Nucleus; Cell Survival; Chromatin; DNA-Binding Proteins; HEK293 Cells; HeLa Cells; Humans; Lysine; Mutant Proteins; NAD; Oxidation-Reduction; Peptide Fragments; Recombinant Proteins; RING Finger Domains; Ubiquitin-Protein Ligases; Ubiquitination; X-Linked Inhibitor of Apoptosis Protein | 2011 |
Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae.
Topics: Amino Acid Substitution; Biocatalysis; Catalytic Domain; Crystallography, X-Ray; Deuterium; Enzyme Stability; Histidine; Hydrogen-Ion Concentration; Kinetics; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; NAD; Protein Conformation; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Saccharopine Dehydrogenases; Viscosity | 2012 |
A biochemical correlate of dimorphism in a zygomycete Benjaminiella poitrasii: characterization of purified NAD-dependent glutamate dehydrogenase, a target for antifungal agents.
Topics: Ammonium Chloride; Antifungal Agents; Candida albicans; Catalysis; Chromatography, Agarose; Drug Evaluation, Preclinical; Fungal Proteins; Glutamate Dehydrogenase; Glutamic Acid; Histidine; Hyphae; Isoelectric Point; Ketoglutaric Acids; Lysine; Molecular Targeted Therapy; Molecular Weight; Mucorales; NAD; Phosphorylation; Protein Processing, Post-Translational; Substrate Specificity; Triazoles; Yarrowia | 2013 |
Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay.
Topics: Acetylation; Fluorometry; Humans; Kinetics; Lysine; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; NAD; Nucleotide Transport Proteins; Peptide Fragments; Sirtuin 1; Substrate Specificity | 2013 |
Detecting sirtuin-catalyzed deacylation reactions using ³²P-labeled NAD and thin-layer chromatography.
Topics: Acetylation; Chromatography, Thin Layer; Glutamate Dehydrogenase; Humans; Kinetics; Lysine; NAD; Peptide Fragments; Phosphates; Protein Processing, Post-Translational; Sirtuins; Substrate Specificity | 2013 |
Spectrophotometric detection of histidine and lysine using combined enzymatic reactions.
Topics: Amino Acyl-tRNA Synthetases; Histidine; Histidine-tRNA Ligase; Hydrogen-Ion Concentration; Lysine; Lysine-tRNA Ligase; NAD; Spectrophotometry | 2013 |
The Arabidopsis class II sirtuin is a lysine deacetylase and interacts with mitochondrial energy metabolism.
Topics: Acetylation; Adenosine Diphosphate; Adenosine Triphosphate; Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Carbon Isotopes; Cell Respiration; Energy Metabolism; Gene Knockout Techniques; Histone Deacetylases; Lysine; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Molecular Sequence Data; NAD; Nonsense Mediated mRNA Decay; Phenotype; Protein Binding; Protein Transport; RNA Splicing; RNA, Messenger; Sirtuins; Substrate Specificity | 2014 |
ND3, ND1 and 39kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I.
Topics: Amino Acid Sequence; Animals; Cattle; Cysteine; Electron Transport Complex I; Electrophoresis, Polyacrylamide Gel; Fluorescence; Lysine; Mass Spectrometry; Molecular Sequence Data; NAD; Oxidation-Reduction | 2014 |
Role of surface residue 184 in the catalytic activity of NADH oxidase from Streptococcus pyogenes.
Topics: Amino Acid Substitution; Enzyme Stability; Flavoproteins; Lysine; Multienzyme Complexes; Mutagenesis, Site-Directed; Mutant Proteins; Mutation, Missense; NAD; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Oxygen; Point Mutation; Streptococcus pyogenes; Temperature; Water | 2014 |
Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels.
Topics: Acetylation; Acrylamides; Enzyme Inhibitors; HEK293 Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lysine; NAD; Phenanthrenes; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Sirtuin 2; Tubulin | 2014 |
Metabolic engineering Corynebacterium glutamicum for the L-lysine production by increasing the flux into L-lysine biosynthetic pathway.
Topics: Corynebacterium glutamicum; Lysine; Metabolic Engineering; NAD | 2014 |
Creation of catalytically active particles from enzymes crosslinked with a natural bifunctional agent--homocysteine thiolactone.
Topics: Animals; Calorimetry, Differential Scanning; Catalysis; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Homocysteine; Hydrodynamics; L-Lactate Dehydrogenase; Lysine; Microscopy, Electron, Transmission; Models, Molecular; NAD; Rabbits | 2014 |
Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation.
Topics: Acetylation; Adenosylhomocysteinase; Amino Acid Sequence; Catalysis; Crystallography, X-Ray; Humans; Hydrogen Bonding; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Plasmids; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Structure-Activity Relationship | 2014 |
Succinylome analysis reveals the involvement of lysine succinylation in metabolism in pathogenic Mycobacterium tuberculosis.
Topics: Acetate-CoA Ligase; Amino Acid Motifs; Amino Acid Sequence; Bacterial Proteins; Blotting, Western; Carbon; Conserved Sequence; Humans; Immunoblotting; Immunoprecipitation; Lysine; Metabolome; Metabolomics; Molecular Dynamics Simulation; Molecular Sequence Annotation; Molecular Sequence Data; Mycobacterium tuberculosis; NAD; Protein Interaction Maps; Protein Transport; Reproducibility of Results; Succinates | 2015 |
Regulation of ribosomal DNA amplification by the TOR pathway.
Topics: Acetylation; DNA, Ribosomal; Environment; Gene Amplification; Histone Deacetylases; Histones; Homologous Recombination; Lysine; Models, Biological; NAD; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Sirolimus | 2015 |
Structural Insight into Dihydrodipicolinate Reductase from Corybebacterium glutamicum for Lysine Biosynthesis.
Topics: Amino Acid Sequence; Binding Sites; Biocatalysis; Corynebacterium glutamicum; Crystallography, X-Ray; Dihydrodipicolinate Reductase; Kinetics; Lysine; Models, Molecular; Mycobacterium tuberculosis; NAD; NADP; Oxidoreductases; Protein Conformation; Protein Structure, Tertiary; Substrate Specificity | 2016 |
Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH.
Topics: Acylation; Biological Assay; Chromatography, High Pressure Liquid; Coumarins; Fluorescent Dyes; Histone Deacetylases; Humans; Hydrolysis; Isoenzymes; Kinetics; Lysine; Mass Spectrometry; Molecular Dynamics Simulation; NAD; Oligopeptides; Protein Processing, Post-Translational; Recombinant Proteins; Sirtuins; Solutions | 2016 |
Identification of structural determinants of NAD(P)H selectivity and lysine binding in lysine N(6)-monooxygenase.
Topics: Amino Acids; Bacterial Proteins; Catalysis; Flavins; Hydrogen Peroxide; Hydroxylation; Kinetics; Lysine; Mixed Function Oxygenases; Molecular Conformation; Mutation; NAD; NADP; Nocardia; Oxygen; Protein Binding | 2016 |
Probing the proton channels in subunit N of Complex I from Escherichia coli through intra-subunit cross-linking.
Topics: Cross-Linking Reagents; Cysteine; Databases, Protein; Electron Transport Complex I; Escherichia coli; Escherichia coli Proteins; Lysine; Maleimides; Models, Molecular; Mutagenesis, Site-Directed; Mutation; NAD; NADH Dehydrogenase; Oxidation-Reduction; Oxidative Phosphorylation; Periplasm; Polyethylene Glycols; Protein Conformation, alpha-Helical; Protein Structure, Tertiary; Protein Subunits; Protons; Structure-Activity Relationship; Ubiquitin | 2016 |
Specific histone modifications play critical roles in the control of encystation and antigenic variation in the early-branching eukaryote Giardia lamblia.
Topics: Acetylation; Antigenic Variation; Euchromatin; Giardia lamblia; Heterochromatin; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Lysine; NAD; Protein Processing, Post-Translational | 2016 |
Regulation of Serine-Threonine Kinase Akt Activation by NAD
Topics: Acetylation; Cell Line; Cell Line, Tumor; Cell Survival; DNA Damage; HEK293 Cells; Humans; Lysine; MCF-7 Cells; NAD; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Sirtuins; Tacrolimus Binding Proteins | 2017 |
Two-metal versus one-metal mechanisms of lysine adenylylation by ATP-dependent and NAD
Topics: Adenosine Triphosphate; Catalytic Domain; Crystallography, X-Ray; DNA Ligases; Escherichia coli; Escherichia coli Proteins; Lysine; Metals; Multiprotein Complexes; NAD; Protein Conformation; RNA Ligase (ATP); Viral Proteins | 2017 |
DFT-based prediction of reactivity of short-chain alcohol dehydrogenase.
Topics: Alcohols; Catalysis; Cluster Analysis; Hydrogen-Ion Concentration; Ketones; Kinetics; Lysine; Molecular Docking Simulation; NAD; Oxidation-Reduction; Oxidoreductases; Quantum Theory; Rhodocyclaceae; Stereoisomerism; Tyrosine | 2017 |
Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors.
Topics: Acrylamides; Binding Sites; Binding, Competitive; Drug Design; Humans; Inhibitory Concentration 50; Lysine; Molecular Docking Simulation; NAD; Protein Isoforms; Protein Structure, Tertiary; Recombinant Proteins; Sirtuins; Structure-Activity Relationship; Substrate Specificity | 2018 |
Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome.
Topics: Acetylation; Animals; ARNTL Transcription Factors; Circadian Clocks; Circadian Rhythm; Cryptochromes; Eating; Liver; Lysine; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Proteins; NAD; Photoperiod; Protein Processing, Post-Translational; Proteome; Sirtuin 3 | 2017 |
Plant DHDPR forms a dimer with unique secondary structure features that preclude higher-order assembly.
Topics: Amino Acid Motifs; Arabidopsis; Bacterial Proteins; Binding Sites; Coenzymes; Crystallography, X-Ray; Dihydrodipicolinate Reductase; Gene Expression; Kinetics; Lysine; Models, Molecular; NAD; NADP; Neisseria meningitidis; Picolinic Acids; Plant Proteins; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Multimerization; Recombinant Proteins; Selaginellaceae; Species Specificity; Substrate Specificity; Vitis | 2018 |
Peptide-Based Fluorescent Probes for Deacetylase and Decrotonylase Activity: Toward a General Platform for Real-Time Detection of Lysine Deacylation.
Topics: Acylation; Benzamides; Enzyme Assays; Fluorescent Dyes; Histone Deacetylases; Humans; Lysine; NAD; Naphthols; Peptides; Sirtuins; Spectrometry, Fluorescence | 2018 |
Characterization of CobB kinetics and inhibition by nicotinamide.
Topics: Acetates; Acetyl Coenzyme A; Acetylation; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Histones; Kinetics; Lysine; NAD; Niacinamide; Phenotype; Plasmids; Protein Folding; Sirtuins; Substrate Specificity | 2017 |
In Streptomyces lividans, acetyl-CoA synthetase activity is controlled by O-serine and N
Topics: Acetate-CoA Ligase; Acetyl Coenzyme A; Acetylation; Acetyltransferases; Aminoacyltransferases; Bacterial Proteins; Cysteine Endopeptidases; DNA, Bacterial; Gene Deletion; Group III Histone Deacetylases; Lysine; NAD; Serine; Streptomyces lividans | 2018 |
Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer.
Topics: Aged; Asian People; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; Down-Regulation; Ethnicity; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Lysine; Male; Middle Aged; NAD; Neoplasm Metastasis; Prognosis; RNA, Messenger; Sirtuins; Survival Analysis | 2018 |
Development of Activity-Based Chemical Probes for Human Sirtuins.
Topics: Animals; Catalytic Domain; Fluorescence; Humans; Lysine; Molecular Probes; NAD; Sirtuins | 2018 |
LC-MS/MS-based quantitative study of the acyl group- and site-selectivity of human sirtuins to acylated nucleosomes.
Topics: Acetylation; Acylation; Acyltransferases; Catalysis; Chromatin; Chromatography, Liquid; Histones; Humans; Hydrophobic and Hydrophilic Interactions; Lysine; Mitochondrial Proteins; NAD; Nucleosomes; Protein Processing, Post-Translational; Sirtuins; Tandem Mass Spectrometry | 2018 |
HPLC-Based Enzyme Assays for Sirtuins.
Topics: Chromatography, High Pressure Liquid; Enzyme Assays; Humans; Kinetics; Lysine; NAD; Peptides; Sirtuin 2; Sirtuins | 2018 |
Efficient mining of natural NADH-utilizing dehydrogenases enables systematic cofactor engineering of lysine synthesis pathway of Corynebacterium glutamicum.
Topics: Corynebacterium glutamicum; Culture Media; Lysine; Metabolic Engineering; Metabolic Networks and Pathways; Models, Molecular; Mutation; NAD; NADH Dehydrogenase; NADPH Dehydrogenase; Pentose Phosphate Pathway; Plasmids | 2019 |
Sustained Activation of AMPK Enhances Differentiation of Human iPSC-Derived Cardiomyocytes via Sirtuin Activation.
Topics: Acetylation; AMP-Activated Protein Kinases; Cell Differentiation; Chromatin; Enzyme Activation; Gene Expression Regulation; Humans; Induced Pluripotent Stem Cells; Lysine; Models, Biological; Myocytes, Cardiac; NAD; Phosphorylation; Sirtuins | 2020 |
Flexible NAD
Topics: Binding Sites; Crystallography, X-Ray; Eukaryota; Lysine; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Conformation; Protein Processing, Post-Translational; Pyrococcus horikoshii; Spermidine | 2020 |
TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.
Topics: Amino Acid Sequence; Antigens, Neoplasm; Binding Sites; DNA Transposable Elements; Epigenesis, Genetic; Exons; Genome; HEK293 Cells; HeLa Cells; Histones; Humans; Lysine; Magnetic Resonance Spectroscopy; Methylation; Multiprotein Complexes; NAD; Nuclear Proteins; Phosphoproteins; Poly(ADP-ribose) Polymerases; Protein Binding; Protein Domains; RNA; RNA Processing, Post-Transcriptional; Transcription, Genetic | 2020 |
Mechanisms to reduce the cytotoxicity of pharmacological nicotinamide concentrations in the pathogenic fungus Candida albicans.
Topics: Candida albicans; Candidiasis; Cell Proliferation; Cell Survival; Fungal Proteins; Histone Deacetylases; Histones; Humans; Lysine; NAD; Niacinamide; Saccharomyces cerevisiae Proteins; Sirtuins | 2021 |
Nucleotide-binding sites can enhance N-acylation of nearby protein lysine residues.
Topics: Acetylation; Acylation; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Binding Sites; Flavin-Adenine Dinucleotide; Lysine; NAD; Nucleotides | 2020 |
Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation.
Topics: 3-Hydroxybutyric Acid; Adenosylhomocysteinase; Amino Acid Sequence; Animals; Cell Line; Humans; Ketone Bodies; Liver; Lysine; Male; Mice, Inbred C57BL; Models, Molecular; NAD; Proteomics | 2021 |
Phosphate stress triggers the conversion of glycerol into l-carnitine in Pseudomonas fluorescens.
Topics: Carnitine; Culture Media; Glycerol; Lysine; NAD; Phosphates; Proteomics; Pseudomonas fluorescens; Stress, Physiological | 2021 |
Post-translational modifications by SIRT3 de-2-hydroxyisobutyrylase activity regulate glycolysis and enable nephrogenesis.
Topics: Animals; Cell Differentiation; Cell Nucleus; Chromatin; Epigenesis, Genetic; Glycolysis; Kidney; Kidney Diseases; Lysine; Mice; Mice, Inbred C57BL; NAD; Nephrons; Organogenesis; Phosphofructokinases; Protein Processing, Post-Translational; Sirtuin 3 | 2021 |
A Novel Mechanism for SIRT1 Activators That Does Not Rely on the Chemical Moiety Immediately C-Terminal to the Acetyl-Lysine of the Substrate.
Topics: Carbon; Lysine; NAD; Ribose; Sirtuin 1; Sirtuin 2; Sirtuin 3; Sirtuins | 2022 |
Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation.
Topics: Acetylation; Catalytic Domain; Humans; Lysine; Mitochondrial Proteins; NAD; NADP; Phosphotransferases (Alcohol Group Acceptor); Proline | 2022 |
Functional Versatility of the Human 2-Oxoadipate Dehydrogenase in the L-Lysine Degradation Pathway toward Its Non-Cognate Substrate 2-Oxopimelic Acid.
Topics: Amino Acid Metabolism, Inborn Errors; Humans; Ketoglutarate Dehydrogenase Complex; Lysine; NAD; Oxidation-Reduction | 2022 |
Quantitative Acetylomics Reveals Dynamics of Protein Lysine Acetylation in Mouse Livers During Aging and Upon the Treatment of Nicotinamide Mononucleotide.
Topics: Acetylation; Animals; Liver; Lysine; Mammals; Mice; NAD; Nicotinamide Mononucleotide; Sirtuins | 2022 |
SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.
Topics: Antiviral Agents; COVID-19; Exoribonucleases; Humans; Lysine; Methyltransferases; NAD; Proviruses; RNA, Viral; SARS-CoV-2; Sirtuins; Viral Nonstructural Proteins | 2022 |
Stable Isotope-Guided Metabolomics Reveals Polar-Functionalized Fatty-Acylated RiPPs from
Topics: Antitubercular Agents; Arginine; Biological Products; Flavin-Adenine Dinucleotide; Isotopes; Lysine; Metabolomics; NAD; Peptides; Pharmaceutical Preparations; Phosphates; Streptomyces; Sulfides; Sulfoxides | 2022 |
Continuous Histone Deacylase Activity Assays.
Topics: Anhydrides; Histone Deacetylases; Histones; Lysine; NAD; Phosphoric Acids; Sirtuins | 2023 |
Dual-channel glycolysis balances cofactor supply for l-homoserine biosynthesis in Corynebacterium glutamicum.
Topics: Corynebacterium glutamicum; Glycolysis; Homoserine; Lysine; Metabolic Engineering; NAD; NADP | 2023 |
Pyrazolone derivatives as potent and selective small-molecule SIRT5 inhibitors.
Topics: Humans; Lysine; NAD; Neoplasms; Pyrazolones; Sirtuins | 2023 |
CycloZ Improves Hyperglycemia and Lipid Metabolism by Modulating Lysine Acetylation in KK-Ay Mice.
Topics: Acetylation; Animals; Diabetes Mellitus, Type 2; Hyperglycemia; Lipid Metabolism; Lysine; Mice; NAD; Sirtuin 1 | 2023 |
Multidimensional engineering of Escherichia coli for efficient biosynthesis of cis-3-hydroxypipecolic acid.
Topics: Escherichia coli; Fermentation; Ketoglutaric Acids; Lysine; Metabolic Engineering; NAD | 2023 |