nad has been researched along with kynurenine in 87 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (42.53) | 18.7374 |
| 1990's | 5 (5.75) | 18.2507 |
| 2000's | 12 (13.79) | 29.6817 |
| 2010's | 13 (14.94) | 24.3611 |
| 2020's | 20 (22.99) | 2.80 |
| Authors | Studies |
|---|---|
| Badawy, AA; Evans, M | 2 |
| Badawy, AA | 2 |
| Verjee, ZH | 1 |
| Shibata, Y | 1 |
| Casida, JE; Engel, JL; Moscioni, AD | 1 |
| Gaertner, FH; Shetty, AS | 2 |
| Beaudoin, AR | 1 |
| Pewnim, T; Seifert, J | 1 |
| Kido, R; Okuno, E | 1 |
| Bender, DA; Danielian, PS; Njagi, EN | 1 |
| Nichols, JS; Wiseman, JS | 1 |
| Bender, DA | 1 |
| Ibrahim, M; Lohmann, C; Lohmann, W | 1 |
| Palmieri, F; Quagliariello, E | 1 |
| Berry, LJ | 1 |
| Diehl, H; Mayer, G; Schmeling, U; Staudinger, H; Ullrich, V | 1 |
| Hayaishi, O; Higuchi, K | 1 |
| Iversen, LL; Jarrott, B | 1 |
| Nicolis, FB; Tenconi, LT | 1 |
| Brown, AT; Wagner, C | 1 |
| Mayer, G; Schmeling, U; Staudinger, H; Ullrich, V | 1 |
| Braidman, IP; Rose, DP | 1 |
| Brown, RR; Wolf, H | 1 |
| Cole, KW; Gaertner, FH; Welch, GR | 1 |
| Capaldi, RA; Hayashi, H | 1 |
| Brown, RR; Hankes, LV; Jansen, CR; Leklem, J; Mekel, RC | 1 |
| Scholz, G; Streffer, C | 1 |
| Streffer, C | 1 |
| Hayaishi, O; Okamoto, H | 2 |
| Hayaishi, O; Okada, F; Okamoto, H | 1 |
| Christoffersen, T; Jervell, KF; Morland, J; Osnes, JB; Seglen, PO | 1 |
| Brody, S | 1 |
| Okamoto, H | 1 |
| Bender, DA; McCreanor, GM | 1 |
| Arend, RA; Brown, RR; Walter, S; Wolf, H | 1 |
| Arend, RA; Brown, RR; Wolf, H | 1 |
| Blinder, KL; Moffett, JR; Namboodiri, MA; Venkateshan, CN | 1 |
| Avanzi, N; Breton, J; Covini, N; Cozzi, L; Isacchi, A; Magagnin, S; Magistrelli, G | 1 |
| Brown, OR; Dale, WE; Dang, Y | 1 |
| Andrew Aquilina, J; Jamie, JF; Taylor, LM; Truscott, RJ | 1 |
| Baran, H; Draxler, M; Kepplinger, B; Nohl, H; Staniek, K; Stur, J | 1 |
| Chiarugi, A; Dello Sbarba, P; Moroni, F; Rovida, E | 1 |
| Moffett, JR; Namboodiri, MA | 1 |
| Grant, R; Kapoor, V | 1 |
| GHOLSON, RK; HAYAISHI, O; ICHIYAMA, A; NISHIZUKA, Y | 1 |
| HAYAISHI, O; ICHIYAMA, A; IKEDA, M; NAKAMURA, S; NISHIZUKA, Y; TSUJI, H | 1 |
| Hashimoto, T; Katoh, A | 1 |
| Forouhar, F; Khan, JA; Tao, X; Tong, L | 1 |
| Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW; Stoy, N | 1 |
| Kujundzić, RN; Lowenthal, JW | 1 |
| Miller, CL | 1 |
| Domanska, G; Fusch, G; Gruendling, M; Haas, JP; Holtfreter, B; Reinke, P; Schefold, JC; Schuett, C; Westerholt, A; Zeden, JP | 1 |
| Chiarugi, A; Cialdai, F; Faraco, G; Formentini, L; Lapucci, A; Moneti, G; Moroni, F; Pittelli, M; Rapizzi, E; Romano, G | 1 |
| Bellac, CL; Christen, S; Coimbra, RS; Leib, SL | 1 |
| Acuña-Castroviejo, D; Camacho, E; Carrión, MD; Doerrier, C; Escames, G; Espinosa, A; López, LC; Mora, F; Tapias, V | 1 |
| Braidy, N; Grant, R; Guillemin, GJ; Massudi, H | 1 |
| Kawai, S; Murata, K; Ohashi, K | 1 |
| Oxenkrug, G | 1 |
| Braidy, N; Bustamante, S; Grant, R; Guillemin, GJ; Lovejoy, D; Sheipouri, D | 1 |
| Badawy, AA; Moffett, JR; Namboodiri, AM | 1 |
| Davis, I; Ha, U; Liu, A; Shin, I; Wang, Y; Yang, Y | 1 |
| Andreasson, KI; Bernstein, D; Contrepois, K; Coronado, M; Dove, C; Joshi, AU; Lee, BA; Liu, L; Majeti, R; Mhatre, S; Migaud, M; Minhas, PS; Mochly-Rosen, D; Moon, PK; Rabinowitz, JD; Snyder, MP; Wang, Q | 1 |
| Adams, S; Castellano-Gonzalez, G; Cole, NJ; Don, E; Guillemin, GJ; Jacobs, KR; Lim, CK; Lovejoy, DB | 1 |
| Adanyeguh, I; Collins, B; Durr, A; Evans, RM; Fan, W; Ichou, F; Kinoshita, C; La Spada, AR; Mochel, F; Morrison, RS; Muotri, AR; Niu, C; Sopher, BL; Stoyas, CA; Switonski, PM; Wall, CE; Ward, JM | 1 |
| Savitz, J | 1 |
| Berge, RK; Bjørndal, B; Lindquist, C; Lund, A; Nygård, O; Skorve, J; Slettom, G; Svardal, A | 1 |
| Castro-Portuguez, R; Sutphin, GL | 1 |
| Arun, P; Badawy, AA; Ives, JA; Moffett, JR; Namboodiri, AM; Puthillathu, N; Vengilote, R | 1 |
| Chakraborty, A; Chatterjee, SK; Dasgupta, AK | 1 |
| Altman, RA; Borel, T; Davis, I; de Azambuja, F; Johnson, D; Liu, A; Sorrentino, JP; Udokwu, C; Yang, Y | 1 |
| Chatton, JY; Gallart-Ayala, H; Ivanisevic, J; Maillard, V; Rosenberg, N; Teav, T; van der Velpen, V | 1 |
| Feun, LG; Nguyen, DJM; Savaraj, N; Spector, SA; Theodoropoulos, G; Wangpaichitr, M; Wu, C | 1 |
| An, SY; Bohney, S; Bommi, PV; Calcutt, MW; Chandel, NS; Gao, P; Gibbs, B; Huang, S; Kapitsinou, PP; Kavanaugh, MA; Kerr, EW; Leonardi, R; Rajendran, G; Schonfeld, M; Tiwari, R; Torosyan, R; Truax, AD | 1 |
| Annesley, SJ; Dehhaghi, M; Fisher, PR; Guillemin, GJ; Heng, B; Kavyani, B; Lidbury, BA; Missailidis, D; Schloeffel, R | 1 |
| Ejtemaei-Mehr, S; Ghahremani, MH; Ghanbari, A; Ghazi-Khansari, M; Guillemin, GJ; Jand, Y | 1 |
| Fathi, M; Hajibeygi, R; Jazi, K; Klegeris, A; McElhinney, A; Sayehmiri, F; Shool, S; Sodeifian, F; Tavasol, A; Tavirani, MR; Vakili, K; Yaghoobpoor, S | 1 |
| Gao, C; Li, S; Mi, P; Qu, H; Shen, J; Tang, X; Wang, S; Xu, B; Yuan, D; Zhang, C; Zhang, P; Zheng, Y | 1 |
| Li, C; Li, T; Liu, D; Liu, Y; Miao, Y; Shen, Q; Zhu, H | 1 |
| Bolaños-Jiménez, F; Croyal, M; García Santillán, JA; Gourdel, M; Mezo-González, CE; Reyes-Castro, LA | 1 |
| Aggarwal, S; Bedi, O; Maiwall, R; Maras, JS; Pamecha, V; Ramakrishna, G; Rastogi, A; Trehanpati, N; Yadav, V | 1 |
| Arslan, AA; Behndig, AF; Brennan, P; Cai, Q; Chen, C; Chen, Y; Fanidi, A; Freedman, ND; Gaziano, JM; Giles, GG; Huang, WY; Johansson, M; Koh, WP; Langhammer, A; Le Marchand, L; Manjer, J; Meyer, K; Midttun, Ø; Prentice, R; Robbins, HA; Sandsveden, M; Sesso, HD; Shu, XO; Stevens, VL; Sørgjerd, EP; Ueland, PM; Ulvik, A; Visvanathan, K; Wang, Y; Weinstein, SJ; Yuan, JM; Zahed, H; Zhang, X; Zheng, W | 1 |
| Landay, AL; MacCann, R; Mallon, PWG | 1 |
| Montua, N; Sewald, N | 1 |
17 review(s) available for nad and kynurenine
| Article | Year |
|---|---|
The functions and regulation of tryptophan pyrrolase.
Topics: Allosteric Regulation; Aminolevulinic Acid; Animals; Dactinomycin; Feedback; Gluconeogenesis; Heme; Kinetics; Kynurenine; Liver; NAD; NADP; Rats; Tryptophan; Tryptophan Oxygenase | 1977 |
Comparison of tryptophan metabolism in vivo and in isolated hepatocytes from vitamin B6 deficient mice.
Topics: Adrenalectomy; Adult; Animals; Cells, Cultured; Child; Female; Humans; Hydrolases; Kinetics; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Male; Mice; Middle Aged; Mixed Function Oxygenases; NAD; Ovariectomy; Oxidation-Reduction; Rats; Tryptophan; Tryptophan Oxygenase; Vitamin B 6 Deficiency | 1991 |
Excretion of tryptophan metabolites as affected by pregnancy, contraceptive steroids, and steroid hormones.
Topics: Androsterone; Animals; Contraceptives, Oral; Enzyme Induction; Estradiol; Female; Humans; Hydrocortisone; Kynurenine; Liver; Male; Megestrol; NAD; Niacinamide; ortho-Aminobenzoates; Pregnancy; Pyridoxine; Rats; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1971 |
Regulation of proinsulin synthesis in pancreatic islets and a new aspect to insulin-dependent diabetes.
Topics: Animals; Base Sequence; Cell Separation; Cell-Free System; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; DNA; DNA, Recombinant; Glucose; Insulin; Islets of Langerhans; Kynurenine; Molecular Weight; NAD; Nucleic Acid Hybridization; Poly(ADP-ribose) Polymerases; Proinsulin; Protein Biosynthesis; RNA; RNA, Messenger; Transcription, Genetic | 1981 |
Tryptophan and the immune response.
Topics: Animals; Dendritic Cells; Dioxygenases; Humans; Immune System; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; NAD; Oxygenases; Poly(ADP-ribose) Polymerases; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 2003 |
Molecular biology of pyridine nucleotide and nicotine biosynthesis.
Topics: Animals; Aspartic Acid; Bacteria; Gene Expression; Kynurenine; Mammals; Models, Chemical; NAD; Nicotiana; Nicotine; Plants; Yeasts | 2004 |
Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery.
Topics: Acrylamides; Adenosine Diphosphate Ribose; Aging; Animals; Antineoplastic Agents; Autoimmune Diseases; Clinical Trials, Phase II as Topic; Cyclic ADP-Ribose; DNA Damage; Drug Design; Enzyme Inhibitors; Humans; Kynurenine; Mice; NAD; Neoplasms; Neurodegenerative Diseases; Neuroprotective Agents; Piperidines; Poly Adenosine Diphosphate Ribose; Signal Transduction; Sirtuins; Tryptophan | 2007 |
Tryptophan, adenosine, neurodegeneration and neuroprotection.
Topics: Adenosine; Animals; Hepatic Encephalopathy; Humans; Kynurenine; NAD; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Tryptophan | 2007 |
NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns.
Topics: Aging; Animals; Cell Death; Cell Membrane; DNA Repair; Energy Metabolism; Enzyme Activation; Humans; Kynurenine; Mammals; NAD; Neurodegenerative Diseases; Oxidative Stress; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Sirtuins | 2012 |
Insulin resistance and dysregulation of tryptophan-kynurenine and kynurenine-nicotinamide adenine dinucleotide metabolic pathways.
Topics: Biomarkers; Humans; Insulin Resistance; Kynurenine; Metabolic Networks and Pathways; NAD; Tryptophan | 2013 |
The end of the road for the tryptophan depletion concept in pregnancy and infection.
Topics: Antigen-Presenting Cells; Communicable Diseases; Female; Fetus; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; NAD; Oxidative Stress; Pregnancy; Pregnancy Complications; Protein Binding; T-Lymphocytes; Tryptophan; Tryptophan Oxygenase | 2016 |
The kynurenine pathway: a finger in every pie.
Topics: Aging; Animals; Energy Metabolism; Humans; Kynurenine; Mental Disorders; NAD; Neurodegenerative Diseases; Signal Transduction; Tryptophan | 2020 |
Kynurenine pathway, NAD
Topics: Aging; Animals; Brain; Humans; Kynurenine; Longevity; Metabolic Networks and Pathways; Mice; Mitochondria; Mitophagy; NAD; Neurodegenerative Diseases; Oxidation-Reduction; Oxidative Stress; Tryptophan | 2020 |
Cisplatin Resistance and Redox-Metabolic Vulnerability: A Second Alteration.
Topics: Cisplatin; Drug Resistance, Neoplasm; Energy Metabolism; Glycolysis; Humans; Kynurenine; Mitochondria; NAD; Neoplasms; Oxidation-Reduction; Poly (ADP-Ribose) Polymerase-1; Reactive Oxygen Species; Sirtuins; Tumor Microenvironment | 2021 |
Could the kynurenine pathway be the key missing piece of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) complex puzzle?
Topics: Fatigue Syndrome, Chronic; Humans; Kynurenine; NAD | 2022 |
Dynamic changes in metabolites of the kynurenine pathway in Alzheimer's disease, Parkinson's disease, and Huntington's disease: A systematic Review and meta-analysis.
Topics: 3-Hydroxyanthranilic Acid; Adenosine; Alzheimer Disease; Humans; Huntington Disease; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; NAD; Niacinamide; Parkinson Disease; Tryptophan | 2022 |
HIV and comorbidities - the importance of gut inflammation and the kynurenine pathway.
Topics: Gastrointestinal Microbiome; HIV Infections; Humans; Inflammation; Kynurenine; NAD | 2023 |
70 other study(ies) available for nad and kynurenine
| Article | Year |
|---|---|
The regulation of rat liver tryptophan pyrrolase activity by reduced nicotinamide-adenine dinucleotide (phosphate). Experiments with glucose and nicotinamide.
Topics: Animals; Diet; Fructose; Glucose; Kynurenine; Liver; Male; Methylphenazonium Methosulfate; NAD; NADP; Niacinamide; Rats; Sucrose; Time Factors; Tryptophan Oxygenase | 1976 |
Tryptophan metabolism in baboons: effect of riboflavin and pyridoxine deficiency.
Topics: 11-Hydroxycorticosteroids; Animals; Erythrocytes; Haplorhini; Kynurenine; Male; NAD; NADP; Papio; Riboflavin Deficiency; Tryptophan; Vitamin B 6 Deficiency | 1975 |
On the regulation of tryptophan metabolism "via" kynurenine.
Topics: Animals; Hydrogen-Ion Concentration; Hydroxyindoleacetic Acid; Hydroxylation; Kynurenine; Mixed Function Oxygenases; NAD; NADP; Nicotinic Acids; ortho-Aminobenzoates; Phenylalanine; Rats; Serotonin; Solubility; Tryptophan; Xanthurenates | 1978 |
Kynurenine formamidase inhibition as a possible mechanism for certain teratogenic effects of organophosphorus and methylcarbamate insecticides in chicken embryos.
Topics: Amidohydrolases; Animals; Arylformamidase; Carbamates; Chick Embryo; Chickens; In Vitro Techniques; Insecticides; Kynurenine; Liver; Male; Mice; NAD; Organophosphorus Compounds; Structure-Activity Relationship; Teratogens; Tryptophan; Tryptophan Oxygenase | 1977 |
Kynureninase-Type enzymes of Penicillum roqueforti, Aspergillus niger, Rhizopus stolonifer, and Pseudomonas fluorescens: further evidence for distinct kynureninase and hydroxykynureninase activities.
Topics: Ammonium Sulfate; Aspergillus; Cell Fractionation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Enzyme Induction; Hydrolases; Hydroxylation; Kynurenine; NAD; ortho-Aminobenzoates; Penicillium; Protamines; Pseudomonas fluorescens; Rhizopus; Species Specificity; Tryptophan | 1975 |
NAD precursors as antiteratogens against aminothiadiazole.
Topics: Animals; Dose-Response Relationship, Drug; Female; Fetal Resorption; Gestational Age; Kynurenine; Male; NAD; Niacinamide; Nicotinic Acids; Pregnancy; Quinolinic Acids; Rats; Teratogens; Thiadiazoles; Tryptophan | 1976 |
Kynureninase-type enzymes and the evolution of the aerobic tryptophan-to-nicotinamide adenine dinucleotide pathway.
Topics: Animals; Anura; Biological Evolution; Chickens; Fungi; Hydrolases; Kynurenine; Liver; Mice; NAD; Pseudomonas fluorescens; Species Specificity; Trout; Tryptophan; Turtles; Xanthomonas | 1977 |
Alteration of mice L-tryptophan metabolism by the organophosphorous acid triester diazinon.
Topics: Animals; Arylformamidase; Diazinon; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Models, Biological; NAD; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1992 |
Kynureninase and kynurenine 3-hydroxylase in mammalian tissues.
Topics: Animals; Eulipotyphla; Humans; Hydrolases; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mitochondria; Mixed Function Oxygenases; NAD; Organ Specificity; Rats; Rats, Inbred Strains; Species Specificity; Tryptophan; Tryptophan Oxygenase | 1991 |
A radiometric kynurenine monooxygenase assay.
Topics: Animals; Chromatography; Kinetics; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; NAD; NADP; Radiometry; Rats; Rats, Inbred Strains; Regression Analysis; Tritium | 1990 |
Effects of a dietary excess of leucine and of the addition of leucine and 2-oxo-isocaproate on the metabolism of tryptophan and niacin in isolated rat liver cells.
Topics: Animals; Caproates; In Vitro Techniques; Keto Acids; Kynurenine; Leucine; Liver; Male; NAD; Niacin; Niacinamide; Rats; Rats, Inbred Strains; Tryptophan; Xanthurenates | 1989 |
Fluorescence spectra of NADH/NAD, kynurenine, tryptophan, and tyrosine.
Topics: Kynurenine; NAD; Oxidation-Reduction; Oxidoreductases; Spectrometry, Fluorescence; Tryptophan; Tyrosine | 1988 |
Effects of tryptophan metabolites on enzymes of oxidative phosphorylation.
Topics: Acetoacetates; Adenine Nucleotides; Amino Acids; Animals; Antimycin A; Cyanides; Cytochromes; Depression, Chemical; Dicumarol; Hydroxybutyrates; In Vitro Techniques; Ketoglutaric Acids; Kynurenic Acid; Kynurenine; Liver; Manometry; Mitochondria, Liver; Mitochondria, Muscle; Myocardium; NAD; Nitriles; ortho-Aminobenzoates; Oxidative Phosphorylation; Oxygen Consumption; Phenylbutyrates; Phenylhydrazines; Polarography; Rats; Rotenone; Spectrophotometry; Stimulation, Chemical; Temperature; Tryptophan; Uncoupling Agents; Xanthurenates | 1971 |
The effects of chronic phenobarbitone administration and subsequent withdrawal on the activity of rat liver tryptohan pyrrolase and their resemblance to those of ethanol.
Topics: Animals; Depression, Chemical; Ethanol; Humans; Hydrocortisone; Injections, Intraperitoneal; Kynurenine; Liver; NAD; NADP; Phenobarbital; Rats; Sodium Chloride; Sodium Salicylate; Substance Withdrawal Syndrome; Time Factors; Tryptophan; Tryptophan Oxygenase | 1973 |
Effect of endotoxin on metabolic regulation in mice.
Topics: Animals; Carbon Radioisotopes; Cortisone; Cyproheptadine; Drug Antagonism; Endotoxins; Energy Metabolism; Enzyme Induction; Injections, Intraperitoneal; Injections, Intravenous; Kynurenine; Lethal Dose 50; Leucine; Liver; Mice; NAD; NADP; Orotic Acid; Protein Biosynthesis; RNA; Tryptophan; Tryptophan Oxygenase; Tyrosine Transaminase | 1973 |
[Studies on the kinetics of L-kynurenine-3-hydroxylase and cytochrome b5 in rat liver mitochondria].
Topics: Animals; Ascorbic Acid; Cytochromes; Depression, Chemical; Dicumarol; Kinetics; Kynurenine; Mitochondria, Liver; Mixed Function Oxygenases; NAD; NADP; Rats | 1969 |
Enzymic formation of D-kynurenine from D-tryptophan.
Topics: Adenine Nucleotides; Animals; Hydrogen Peroxide; Ileum; In Vitro Techniques; Intestine, Small; Kynurenine; Methylene Blue; NAD; Nucleosides; Oxygen Consumption; Oxygenases; Rabbits; Tryptophan; Tryptophan Oxygenase | 1967 |
Subcellular distribution of monoamine oxidase activity in rat liver and vas deferens.
Topics: Animals; Centrifugation, Density Gradient; Kynurenine; Liver; Male; Microsomes; Mitochondria, Liver; Mixed Function Oxygenases; Monoamine Oxidase; NAD; Norepinephrine; Oxidoreductases; Proteins; Rats; Succinate Dehydrogenase; Vas Deferens | 1968 |
[Apropos of the effect of roentgen irradiation on tryptophan pyrrolase and NAD].
Topics: Animals; Kynurenine; Liver; Mice; NAD; Radiation Effects; Rats; Species Specificity; Tryptophan Oxygenase | 1969 |
Regulation of enzymes involved in the conversion of tryptophan to nicotinamide adenine dinucleotide in a colorless strain of Xanthomonas pruni.
Topics: Amidohydrolases; Enzyme Induction; Hydrolases; Kynurenine; Mutation; NAD; ortho-Aminobenzoates; Oxygenases; Tryptophan; Tryptophan Oxygenase; Xanthomonas | 1970 |
Possible involvement of cytochrome b5 in L-kynurenine 3-hydroxylase.
Topics: Animals; Cytochromes; Kinetics; Kynurenine; Mitochondria, Liver; Mixed Function Oxygenases; NAD; Rats | 1968 |
Studies on tryptophan metabolism in male subjects treated with hydrocortisone.
Topics: Chromatography, Ion Exchange; Humans; Hydrocortisone; Kynurenic Acid; Kynurenine; Male; NAD; Pyridoxine; Statistics as Topic; Tryptophan | 1971 |
Evidence for distinct kynureninase and hydroxykynureninase activities in Neurospora crassa.
Topics: Cell-Free System; Chromatography, DEAE-Cellulose; Culture Media; Enzyme Induction; Fluorometry; Hydrolases; Kynurenine; Magnesium Sulfate; Models, Chemical; NAD; Neurospora; ortho-Aminobenzoates; Pyridoxal Phosphate; Tryptophan | 1971 |
The proteins of the outer membrane of beef heart mitochondria.
Topics: Animals; Cattle; Centrifugation, Density Gradient; Cytochrome c Group; Cytochromes; Electrophoresis, Polyacrylamide Gel; Flavins; Glucose-6-Phosphatase; Hypotonic Solutions; Kynurenine; Membranes; Microscopy, Electron; Mitochondria, Muscle; Mixed Function Oxygenases; Molecular Weight; Monoamine Oxidase; Muscle Proteins; Myocardium; NAD; Oxidoreductases; Peptides; Rotenone | 1972 |
Abnormal tryptophan metabolism in patients with scurvy-type skin.
Topics: Acetates; Adult; Aminohippuric Acids; Black or African American; Black People; Ethnicity; Glucuronates; Hemosiderosis; Humans; Indoles; Kynurenic Acid; Kynurenine; Male; NAD; Niacinamide; Nicotinic Acids; ortho-Aminobenzoates; Pyridines; Scurvy; South Africa; Sulfuric Acids; Tryptophan; Xanthurenates | 1973 |
Metabolism of pyridine nucleotides and its relation to DNA synthesis in regenerating mouse liver.
Topics: Adenine Nucleotides; Animals; DNA; Female; Hepatectomy; Hydrolases; Kynurenine; Liver; Liver Regeneration; Mice; Mice, Inbred Strains; NAD; Niacinamide; Nicotinamide Mononucleotide; Nucleotidyltransferases; ortho-Aminobenzoates; Pentosyltransferases; Transaminases; Tryptophan | 1972 |
[Proceedings: NAD biosynthesis from tryptophan in mouse liver].
Topics: Animals; DNA; Hydrolases; Kynurenine; Liver; Liver Regeneration; Mice; NAD; Niacinamide; Nicotinic Acids; Thymidine; Tryptophan | 1972 |
Solubilization and partial purification of kynurenine hydroxylase from mitochondrial outer membrane and its electron donors.
Topics: Animals; Antimycin A; Cyanides; Cytochromes; Electron Transport; Kynurenine; Membranes; Mitochondria, Liver; Mixed Function Oxygenases; NAD; NADP; Oxidoreductases; Rats; Rotenone; Spectrum Analysis | 1969 |
Localization and some properties of kynurenine-3-hydroxylase and kynurenine aminotransferase.
Topics: Animals; Antimycin A; Cyanides; Cytochromes; Depression, Chemical; Electron Transport; Flavin-Adenine Dinucleotide; Hydrolases; Kynurenine; Liver; Membranes; Mitochondria, Liver; Mixed Function Oxygenases; NAD; NADP; Oxidoreductases; Rats; Rotenone; Transaminases | 1971 |
Kynurenine metabolism in hyperthyroidism. A biochemical basis for the low NAD(P) level in hyperthyroid rat liver.
Topics: Animals; Cycloheximide; Enzyme Induction; Ethionine; Hydrolases; Hyperthyroidism; Kynurenine; Liver; Male; Membranes; Mitochondria, Liver; Mixed Function Oxygenases; NAD; NADP; Rats; Thyroxine; Transaminases | 1971 |
An effect of ethanol administration on tryptophan oxygenase in the perfused rat liver. Decreased enzyme synthesis dependent on low perfusate pH.
Topics: Acetates; Animals; Bile; Cycloheximide; Ethanol; Glucose; Hydrochloric Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Kynurenine; Lactates; Liver; Male; NAD; Perfusion; Pyrazoles; Rats; Time Factors; Tryptophan Oxygenase; Tyrosine Transaminase | 1972 |
Regulation of pyridine nucleotide levels and ratios in Neurospora crassa.
Topics: Culture Media; Genetics, Microbial; Glucosephosphate Dehydrogenase; Kynurenine; Mixed Function Oxygenases; Mutation; NAD; NADP; Neurospora; Neurospora crassa; Nicotinic Acids; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Tryptophan | 1972 |
The preferred route of kynurenine metabolism in the rat.
Topics: Animals; Hydrolases; Kinetics; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Myocardium; NAD; NADP; Rats; Rats, Inbred Strains | 1982 |
Effect of natural oestrogens on tryptophan metabolism: evidence for interference of oestrogens with kynureninase.
Topics: Aged; Estradiol; Estriol; Estrogens; Female; Humans; Hydrolases; Kynurenine; Menopause; Middle Aged; NAD; Pyridoxal Phosphate; Pyridoxic Acid; Pyridoxine; Tryptophan | 1980 |
The kynurenine load test, an adjunct to the tryptophan load test.
Topics: 3-Hydroxyanthranilic Acid; Aged; Female; Humans; Kynurenine; Menopause; Middle Aged; NAD; Pyridoxine; Tryptophan | 1980 |
Differential effects of kynurenine and tryptophan treatment on quinolinate immunoreactivity in rat lymphoid and non-lymphoid organs.
Topics: Animals; Immunohistochemistry; Injections, Intraperitoneal; Kynurenine; Lymphoid Tissue; Male; NAD; Organ Specificity; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan | 1998 |
Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase.
Topics: Animals; Chlorides; COS Cells; Flavin-Adenine Dinucleotide; Humans; Hydrogen-Ion Concentration; Ions; Kinetics; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Molecular Weight; NAD; NADP; NADPH Oxidases; Oxidation-Reduction; Peroxides; Pyridoxal Phosphate; Recombinant Fusion Proteins; Substrate Specificity; Thermodynamics; Transfection | 2000 |
Tryptophan metabolism through the kynurenine pathway in rat brain and liver slices.
Topics: Aerobiosis; Animals; Brain; In Vitro Techniques; Kynurenine; Liver; Male; NAD; Organ Specificity; Oxygen; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan | 2000 |
Glutathione and NADH, but not ascorbate, protect lens proteins from modification by UV filters.
Topics: Animals; Ascorbic Acid; Cattle; Crystallins; Glutathione; Hydrogen-Ion Concentration; Kynurenine; Lens, Crystalline; NAD; Ultraviolet Rays | 2002 |
Kynurenines and the respiratory parameters on rat heart mitochondria.
Topics: 3-Hydroxyanthranilic Acid; Animals; Free Radical Scavengers; In Vitro Techniques; Kinetics; Kynurenine; Male; Mitochondria, Heart; Mitochondrial Proteins; NAD; ortho-Aminobenzoates; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Succinates; Tryptophan | 2003 |
Tryptophan availability selectively limits NO-synthase induction in macrophages.
Topics: Animals; Arginine; Cell Line; Enzyme Induction; Interferon-gamma; Kynurenine; Macrophages; Mice; NAD; Nitric Oxide; Nitric Oxide Synthase; Tryptophan; Tryptophan Oxygenase; Tumor Necrosis Factor-alpha | 2003 |
Inhibition of indoleamine 2,3-dioxygenase activity in IFN-gamma stimulated astroglioma cells decreases intracellular NAD levels.
Topics: Astrocytes; Astrocytoma; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; NAD; Tryptophan; Tryptophan Oxygenase; Tumor Cells, Cultured | 2003 |
STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN MAMMALIAN TISSUES. I. ENZYMIC FORMATION OF GLUTARIC ACID FROM 3-HYDROXYANTHRANILIC ACID.
Topics: 3-Hydroxyanthranilic Acid; Amino Acids; Animals; Benzene; Carbon Dioxide; Carbon Isotopes; Cats; Chromatography; Coenzyme A; Electrophoresis; Glutarates; Keto Acids; Kynurenine; Liver; Metabolism; NAD; ortho-Aminobenzoates; Pseudomonas; Pyridines; Research; Tryptophan | 1965 |
STUDIES ON THE BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE. II. A ROLE OF PICOLINIC CARBOXYLASE IN THE BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE FROM TRYPTOPHAN IN MAMMALS.
Topics: Animals; Carbon Isotopes; Cats; Diabetes Mellitus, Experimental; Glutarates; Kidney; Kynurenine; Ligases; Liver; Mammals; Metabolism; NAD; Nucleotides; Phosphotransferases; Radiometry; Rats; Research; Transferases; Tryptophan | 1965 |
The role of tryptophan metabolism in iNOS transcription and nitric oxide production by chicken macrophage cells upon treatment with interferon gamma.
Topics: Animals; Cell Line, Tumor; Chickens; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Macrophages; NAD; Nitric Oxide; Nitric Oxide Synthase Type II; Poly(ADP-ribose) Polymerases; Transcription, Genetic; Tryptophan | 2008 |
The evolution of schizophrenia: a model for selection by infection, with a focus on NAD.
Topics: Biological Evolution; Humans; Kynurenine; Models, Biological; NAD; Schizophrenia; Selection, Genetic; Tuberculosis | 2009 |
Excessive tryptophan catabolism along the kynurenine pathway precedes ongoing sepsis in critically ill patients.
Topics: Adult; Critical Illness; Female; Humans; Kynurenine; Male; Middle Aged; NAD; Renal Insufficiency; Sepsis; Tryptophan | 2010 |
Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool.
Topics: Acrylamides; Adenosine Triphosphate; Animals; Enzyme Inhibitors; Fibroblasts; HeLa Cells; Humans; Kynurenine; Male; Mice; Mitochondria; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Poly(ADP-ribose) Polymerases | 2010 |
Inhibition of the kynurenine-NAD+ pathway leads to energy failure and exacerbates apoptosis in pneumococcal meningitis.
Topics: Animals; Animals, Newborn; Apoptosis; Chromatography, High Pressure Liquid; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Energy Metabolism; Hippocampus; Kynurenine; Meningitis, Pneumococcal; Myelin Basic Protein; NAD; Rats; Rats, Wistar; Signal Transduction; Sulfonamides; Thiazoles | 2010 |
Protective effects of synthetic kynurenines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Cytosol; Disease Models, Animal; Drug Administration Schedule; Kynurenine; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Mitochondria; MPTP Poisoning; NAD; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitrites; Oxidation-Reduction; Substantia Nigra | 2011 |
Secretion of quinolinic acid, an intermediate in the kynurenine pathway, for utilization in NAD+ biosynthesis in the yeast Saccharomyces cerevisiae.
Topics: Biosynthetic Pathways; Culture Media, Conditioned; Gene Expression; Gene Knockout Techniques; Genes, Fungal; Kynurenine; Membrane Transport Proteins; Microbial Viability; NAD; Pentosyltransferases; Quinolinic Acid; Saccharomyces cerevisiae; Transcription, Genetic | 2013 |
Characterisation of the kynurenine pathway in skin-derived fibroblasts and keratinocytes.
Topics: Cells, Cultured; Chromatography, Gas; Chromatography, High Pressure Liquid; Fibroblasts; Humans; Immunohistochemistry; Interferon-gamma; Keratinocytes; Kynurenine; L-Lactate Dehydrogenase; NAD; Skin; Tryptophan; Ultraviolet Rays | 2015 |
A Pitcher-and-Catcher Mechanism Drives Endogenous Substrate Isomerization by a Dehydrogenase in Kynurenine Metabolism.
Topics: Amino Acid Substitution; Bacterial Proteins; Kynurenine; Mutation, Missense; NAD; Oxidoreductases; Pseudomonas fluorescens | 2016 |
Macrophage de novo NAD
Topics: Aging; Animals; Cells, Cultured; Homeostasis; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NAD; Oxidative Phosphorylation; Pentosyltransferases; Phagocytosis; Signal Transduction; Tryptophan | 2019 |
Kynurenine 3-Monooxygenase Activity in Human Primary Neurons and Effect on Cellular Bioenergetics Identifies New Neurotoxic Mechanisms.
Topics: Adenosine Triphosphate; Brain; Cell Survival; HEK293 Cells; Humans; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Diseases; NAD; Neurons; Oxidative Stress; Primary Cell Culture; Quinolinic Acid; Reactive Oxygen Species | 2019 |
Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease.
Topics: Adipose Tissue; Animals; Ataxin-7; Blood Glucose; Energy Metabolism; Humans; Kynurenine; Metabolomics; Mice; Mitochondria; Mitochondrial Diseases; NAD; Neural Stem Cells; Organelles; Peptides; Phenotype; Purkinje Cells; Reproducibility of Results; Spinocerebellar Ataxias; Trinucleotide Repeat Expansion; Tryptophan | 2019 |
Increased fatty acid oxidation and mitochondrial proliferation in liver are associated with increased plasma kynurenine metabolites and nicotinamide levels in normolipidemic and carnitine-depleted rats.
Topics: Animals; Carnitine; Cell Proliferation; Kynurenine; Lipid Metabolism; Liver; Male; Metabolic Networks and Pathways; Methylhydrazines; Mitochondria; NAD; Niacinamide; Oxidation-Reduction; Peroxisomes; Rats; Tryptophan | 2020 |
Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NAD
Topics: Animals; Biomarkers; Cell Movement; Gerbillinae; Hippocampus; HSP90 Heat-Shock Proteins; Immunity; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; NAD; Pokeweed Mitogens; Poly(ADP-ribose) Polymerases; Quinolinic Acid; Rats; Spleen; Tryptophan | 2020 |
Label-free detection of thalassemia and other ROS impairing diseases.
Topics: Algorithms; Arthritis, Rheumatoid; Humans; Kynurenine; NAD; Oxidative Stress; Principal Component Analysis; Reactive Oxygen Species; ROC Curve; Spectrometry, Fluorescence; Spectrum Analysis, Raman; Thalassemia; Tryptophan | 2020 |
Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan-Kynurenine Pathway.
Topics: Bacterial Proteins; Binding Sites; Biosynthetic Pathways; Carboxy-Lyases; Catalytic Domain; Crystallography, X-Ray; Diflunisal; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kynurenine; Molecular Docking Simulation; NAD; Pseudomonas fluorescens; Structure-Activity Relationship; Tryptophan | 2021 |
Sex-specific alterations in NAD+ metabolism in 3xTg Alzheimer's disease mouse brain assessed by quantitative targeted LC-MS.
Topics: Alzheimer Disease; Animals; Chromatography, High Pressure Liquid; Encephalitis; Female; Humans; Kynurenic Acid; Kynurenine; Male; Metabolome; Mice; Mice, Transgenic; NAD; Neuroprotection; Nicotinamide Mononucleotide; Sex Characteristics; Tandem Mass Spectrometry | 2021 |
Hypoxic preconditioning protects against ischemic kidney injury through the IDO1/kynurenine pathway.
Topics: Animals; Hypoxia; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Ischemia; Kidney; Kynurenine; Metabolome; Mice, Inbred C57BL; Mice, Knockout; NAD; Procollagen-Proline Dioxygenase; Protective Agents; Tryptophan | 2021 |
Melatonin ameliorates disease severity in a mouse model of multiple sclerosis by modulating the kynurenine pathway.
Topics: Animals; Biological Factors; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Melatonin; Mice; Mice, Inbred C57BL; Multiple Sclerosis; NAD; Nicotinamide N-Methyltransferase; Receptors, Aryl Hydrocarbon; RNA, Messenger; Severity of Illness Index; Tryptophan | 2022 |
Metabolic Rewiring of Kynurenine Pathway during Hepatic Ischemia-Reperfusion Injury Exacerbates Liver Damage by Impairing NAD Homeostasis.
Topics: Animals; Homeostasis; Kynurenine; Liver; Mice; NAD; Reperfusion Injury | 2022 |
Intracellular kynurenine promotes acetaldehyde accumulation, further inducing the apoptosis in soil beneficial fungi Trichoderma guizhouense NJAU4742 under acid stress.
Topics: Acetaldehyde; Apoptosis; Hypocreales; Kynurenine; NAD; Protons; Soil; Trichoderma | 2023 |
Obesity-Induced Memory Deficits in Female Rats Are Oestrous Cycle Dependent and Linked to Impaired Brain Kynurenine Pathway Metabolism.
Topics: Animals; Brain; Female; Kynurenic Acid; Kynurenine; Memory Disorders; NAD; Obesity; Rats; Tryptophan | 2023 |
Metabolomic analysis shows dysregulation in amino acid and NAD+ metabolism in palmitate treated hepatocytes and plasma of non-alcoholic fatty liver disease spectrum.
Topics: Amino Acids; Hepatocytes; Humans; Kynurenine; Liver; Liver Cirrhosis; NAD; Non-alcoholic Fatty Liver Disease; Palmitates; Palmitic Acid; Tryptophan | 2023 |
A cross-sectional study of inflammatory markers as determinants of circulating kynurenines in the Lung Cancer Cohort Consortium.
Topics: Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Humans; Inflammation; Interferon-gamma; Kynurenine; Lung Neoplasms; NAD; Neopterin; Tryptophan | 2023 |
The kynurenine pathway of tryptophan metabolism: a neglected therapeutic target of COVID-19 pathophysiology and immunotherapy.
Topics: COVID-19; Humans; Immunotherapy; Kynurenine; NAD; Poly(ADP-ribose) Polymerase Inhibitors; SARS-CoV-2; Tryptophan | 2023 |
Extended Biocatalytic Halogenation Cascades Involving a Single-Polypeptide Regeneration System for Diffusible FADH
Topics: Flavins; Halogenation; Kynurenine; NAD; Oxidoreductases; Peptides; Regeneration | 2023 |