Compounds > nad
Page last updated: 2024-08-17

nad and fk 866

nad has been researched along with fk 866 in 91 studies

Research

Studies (91)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's16 (17.58)29.6817
2010's67 (73.63)24.3611
2020's8 (8.79)2.80

Authors

AuthorsStudies
Hasmann, M; Schemainda, I1
Alfieri, AA; Chen, Y; Hasmann, M; Koutcher, JA; Matei, C; Muruganandham, M; Saltz, LB; Schemainda, I; Sukenick, G1
Azzam, K; Hasmann, M; Nüssler, V; Pelka-Fleischer, R; Pogrebniak, A; Schemainda, I1
Forouhar, F; Khan, JA; Tao, X; Tong, L1
Burk, K; Hanauske, AR; Holen, K; Hollywood, E; Saltz, LB1
Billington, RA; Canonico, PL; Condorelli, F; Ercolano, E; Galli, U; Genazzani, AA; Grolla, AA; Roman, CB; Travelli, C1
Björkling, F; Christensen, MK; Jäättelä, M; Jensen, PB; Nielsen, SJ; Olesen, UH; Sehested, M1
Billington, RA; Condorelli, F; Genazzani, AA; Travelli, C1
Billington, RA; Blasi Roman, CR; Canonico, PL; Carraro, L; Ercolano, E; Galli, U; Genazzani, AA; Sorba, G; Tron, GC1
Burgos, ES; Schramm, VL1
Attinger, A; Aubry, D; Dawson, KM; Duchosal, MA; Dupuis, M; Greaney, P; Ireson, C; Nahimana, A; Thougaard, AV; Tjørnelund, J1
Astarita, G; Kaluzova, M; Nakahata, Y; Sahar, S; Sassone-Corsi, P1
Abrassart, D; Bass, J; Brace, CS; Buhr, ED; Chong, JL; Hong, HK; Imai, S; Kobayashi, Y; Lee, C; Marcheva, B; Ramsey, KM; Takahashi, JS; Yoshino, J1
Wijnen, H1
Chiarugi, A; Formentini, L; Moroni, F1
Berglund, A; Larsson, R; Nygren, P; von Heideman, A1
Ballestrero, A; Benvenuto, F; Bruzzone, S; Cea, M; D'Urso, A; Ferrando, T; Fruscione, F; Garuti, A; Moran, E; Morando, S; Mostoslavsky, R; Nencioni, A; Patrone, F; Poggi, A; Selmo, M; Soncini, D; Sordat, B; Uccelli, A; Zoppoli, G1
Jensen, PB; Olesen, UH; Sehested, M; Thougaard, AV1
Bi, TQ; Che, XM1
Ballestrero, A; Bedognetti, D; Belka, C; Bruzzone, S; Caffa, I; Cea, M; Ferrando, F; Fruscione, F; Ghio, R; Moran, E; Motta, G; Nencioni, A; Parodi, S; Patrone, F; Rudner, J; Soncini, D; Zoppoli, G1
Chiarugi, A; Cialdai, F; Faraco, G; Formentini, L; Lapucci, A; Moneti, G; Moroni, F; Pittelli, M; Rapizzi, E; Romano, G1
Brown, AR; Goellner, EM; Grimme, B; Lin, YC; Mitchell, L; Sobol, RW; Sugrue, KF; Tang, JB; Trivedi, RN; Wang, XH1
Ansaldi, F; Ballestrero, A; Bergamaschi, M; Bruzzone, S; Caffa, I; Cagnetta, A; Casciaro, S; Cea, M; Damonte, G; Emionite, L; Fruscione, F; Garuti, A; Gobbi, M; Magnone, M; Moran, E; Nencioni, A; Patrone, F; Pierri, I; Pistoia, V; Raffaghello, L; Reverberi, D; Salis, A; Soncini, D; Zoppoli, G1
Ceglarek, U; Hauschildt, S; Klein, C; Raulien, N; Schilling, E; Wehrhahn, J1
Bi, J; Ding, S; Li, H; Ye, SQ1
Fang, SH; Hu, H; Ling, KN; Liu, LY; Lu, YB; Qie, LL; Wang, F; Wei, EQ; Xu, LH; Zhang, LY; Zhang, WP1
Chandra, P; Dittrich, T; Lippka, Y; Skokowa, J; Thakur, BK; Welte, K1
Akhmedov, A; Bauer, I; Bertolotto, M; Braunersreuther, V; Bruzzone, S; Dallegri, F; Galan, K; Garuti, A; Gayet-Ageron, A; Lenglet, S; Lerch, R; Lüscher, TF; Mach, F; Mage, J; Mannino, E; Montecucco, F; Montessuit, C; Mostoslavsky, R; Nencioni, A; Patrone, F; Pelli, G; Pellieux, C; Poggi, A; Sebastian, C; Speer, T; Vuilleumier, N1
Bauer, I; Brini, M; Bruzzone, S; De Flora, A; Magnone, M; Mannino, E; Nencioni, A; Poggi, A; Sturla, L; Zocchi, E1
Camacho-Pereira, J; Chini, CC; Chini, EN; Escande, C; Giri, S; Lou, Z; Matalonga, J; Nin, V1
Becker, A; Chandra, P; Dittrich, T; Klusmann, JH; Kuehnau, W; Reinhardt, D; Thakur, BK; Welte, K1
Anderson, KC; Cagnetta, A; Calimeri, T; Cea, M; Chauhan, D; Cottini, F; Fulciniti, M; Gobbi, M; Hideshima, T; Jakubikova, J; Kong, SY; Munshi, N; Nencioni, A; Patrone, F; Richardson, P; Roccaro, A; Sacco, A; Tai, YT1
Huang, P; Liu, LY; Lu, YB; Wang, F; Wei, EQ; Zhang, WP; Zhang, XY1
Anderson, KC; Cagnetta, A; Cea, M; Gobbi, M; Nencioni, A; Patrone, F1
Burkholder, TP; Geeganage, S; Gillig, J; Huss, K; Kuo, MS; Lu, ZH; Meier, TI; Parthasarathy, S; Roth, K; Shepard, RL; Smith, MC; Tan, B; Wang, T; Young, DA; Zhai, Y; Zhao, G1
Felding-Habermann, B; Gay, LJ; LeBoeuf, SE; Matsuno-Yagi, A; Ritland, M; Santidrian, AF; Seo, BB; Yagi, T1
Bam, R; Barlogie, B; Epstein, J; Khan, S; Li, X; Ling, W; Usmani, S; van Rhee, F; Venkateshaiah, SU; Yaccoby, S1
Acharya, C; Anderson, KC; Cagnetta, A; Calimeri, T; Cea, M; Chauhan, D; Fulciniti, M; Gobbi, M; Hideshima, T; Munshi, N; Nencioni, A; Patrone, F; Richardson, P; Tai, YT; Zhong, MY1
Bruzzone, S; Caffa, I; De Flora, A; Grozio, A; Nencioni, A; Raffaelli, N; Salis, A; Sociali, G; Soncini, D; Sturla, L1
Barbosa, MT; Camacho-Pereira, J; Chini, CC; Chini, EN; Escande, C; Guerrico, AM; Nin, V1
Cantley, LC; Lyssiotis, CA1
Fukuwatari, T; Ito, M; Kaneko, I; Kido, S; Miyagawa, A; Miyamoto, K; Nomura, K; Sano, M; Sasaki, S; Segawa, H; Shibata, K; Shiozaki, Y; Tatsumi, S1
Amedei, A; Cavone, L; Chiarugi, A; Felici, R; Lapucci, A; Niccolai, E; Oteri, C; Pittelli, M1
Aubry, D; Breton, CS; Duchosal, MA; Majjigapu, SR; Nahimana, A; Sordat, B; Vogel, P1
Benito-Martin, A; Carrasco, S; Egido, J; Izquierdo, MC; Lorenzo, O; Ortiz, A; Picatoste, B; Ruiz-Ortega, M; Santamaria, B; Ucero, AC1
Floot, B; van Triest, B; Vens, C; Verheij, M; Zerp, SF1
Aubry, D; Breton, C; Bruzzone, S; Cloux, AJ; Duchosal, MA; Ginet, V; Majjigapu, SR; Nahimana, A; Nencioni, A; Puyal, J; Rummel, C; Sordat, B; Vogel, P1
Camp, SM; Deaton, R; Gann, PH; Garcia, JG; Letsiou, E; Ma, W; Machado, RF; Messana, J; Moreno-Vinasco, L; Quijada, H; Saadat, L; Sammani, S; Siegler, J; Wang, T; Zaidi, RS1
Dölle, C; Skoge, RH; Ziegler, M1
Fransen, JA; Oerlemans, FT; Venter, G; Wieringa, B; Wijers, M; Willemse, M1
Andrabi, SA; Chang, C; Dawson, TM; Dawson, VL; Gagné, JP; Karuppagounder, SS; Poirier, GG; Stevens, DA; Umanah, GK1
Chang, YZ; Chen, MY; Hu, ML; Song, TY; Yang, NC1
Ai, Y; Jia, SH; Marshall, JC; Parodo, J; Peng, Q1
Jiang, WX; Lu, JT; Lu, YB; Tang, C; Wei, EQ; Wu, M; Zhang, WP; Zhang, XQ1
Chessler, SD; Chi, NW; Hao, J; Mahata, SK; Pourtabatabaei, N; Shao, J; Yeh, TY; Zhong, L1
Dong, S; Geeganage, S; Kays, L; Kuo, MS; Roth, KD; Shepard, RL; Tan, B; Zhao, G1
Acharya, C; Acharya, P; Adamia, S; Ballestrero, A; Bergamaschi, M; Bruzzone, S; Caffa, I; Cagnetta, A; Cea, M; Damonte, G; Fraternali, G; Garuti, A; Gobbi, M; Mastracci, L; Montecucco, F; Nencioni, A; Patrone, F; Pierri, I; Provenzani, A; Salis, A; Soncini, D; Zucal, C1
Lavandero, S; López-Crisosto, C; Oyarzún, AP; Parra, V; Pedrozo, Z; Pennanen, C; Sánchez, G; Sotomayor-Flores, C; Troncoso, R; Westermeier, F1
Chen, MY; Hu, ML; Song, TY; Yang, NC; Yeh, SL1
Ballestrero, A; Caffa, I; Casini, A; Cea, M; D'Agostino, VG; Indraccolo, S; Mantelli, B; Nencioni, A; Provenzani, A; Quattrone, A; Soncini, D; Thongon, N; Zucal, C1
Choi, KY; Hong, SM; Im, SH; Kim, KT; Kim, SW; Nam, YJ; Park, CW; Shin, JH; Sung, YC; Yu, JH; Yun, CH1
Chen, D; Di Cresce, C; Ferguson, PJ; Figueredo, R; Koropatnick, J; Maleki Vareki, S; Min, W; Pampillo, M; Rytelewski, M; Vincent, M; Zheng, X1
Lu, YB; Shi, QJ; Wei, EQ; Wu, M; Yang, P; Zhang, L; Zhang, WP1
Bianchi, G; Bruzzone, S; Emionite, L; Magnone, M; Nahimana, A; Nencioni, A; Raffaelli, N; Raffaghello, L; Sociali, G; Sturla, L; Vigliarolo, T; Zamporlini, F1
Chiao, PJ; Fan, XQ; Ju, HQ; Li, H; Lu, YX; Mo, HY; Sheng, H; Tian, T; Xu, RH; Zhou, HJ; Zhuang, ZN1
Alonso, J; Aryee, DNT; Ban, J; Banerji, V; Bouchard, EDJ; Garten, A; Hatch, GM; Katschnig, AM; Kauer, MO; Kovar, H; Mejia, EM; Mutz, CN; Schwentner, R1
Deng, KY; Guan, XH; Hu, L; Huang, CC; Qian, YS; Wang, LF; Wang, XN; Xiao, YF; Xin, HB1
Batchelor, TT; Cahill, DP; Chi, AS; Fisher, DE; Higuchi, F; Iafrate, AJ; Koerner, MVA; Lelic, N; Miller, JJ; Shankar, GM; Tanaka, S; Tateishi, K; Wakimoto, H1
Li, D; Li, L; Lv, C; Xu, R; Yang, L; Yuan, Z1
Alaee, M; Behrouzfar, K; Gholinejad, Z; Golestani, A; Nourbakhsh, M1
Adolph, TE; Arnhard, K; Baier, G; Gerner, RR; Grander, C; Hermann-Kleiter, N; Klepsch, V; Macheiner, S; Moschen, AR; Moser, P; Oberacher, H; Pfister, A; Tilg, H; Wieser, V1
Garten, A; Gebhardt, R; Gorski, T; Kiess, W; Penke, M; Schuster, S1
Baczkó, I; Blanc, J; Brenner, C; Breton, M; Decaux, JF; Deloux, R; Diguet, N; Garnier, A; Gouge, A; Gressette, M; Lavery, GG; Li, Z; Manoury, B; Mericskay, M; Mougenot, N; Piquereau, J; Tannous, C; Trammell, SAJ; Zoll, J1
Deng, H; Hu, Y; Wang, Q; Wang, W; Wang, X1
Beg, MS; Hosein, AN1
Bartoli, M; Fuller, J; Jadeja, RN; Jones, MA; Joseph, E; Martin, PM; Powell, FL; Thounaojam, MC1
Deng, H; Hu, Y; Wang, W; Wang, X; Yang, C; Zhang, Z; Zhu, S1
Bowlby, SC; Chmielewski, JP; Cramer, SD; D'Agostino, RB; Davis, AL; Howard, TD; Kridel, SJ; Miller, LD; Shi, L; Sirintrapun, SJ; Sui, G; Wheeler, FB1
Brenner, C; Cambronne, XA; Cohen, MS; Goodman, RH; Liu, HW; Migaud, ME; Schmidt, MS; Smith, CB1
Bellanger, S; Chin, T; Oblong, JE; Quek, LS; Rovito, HA; Tan, CL; Tan, CYR1
Buescher, JM; Cameron, AM; Castoldi, A; Field, CS; Flachsmann, LJ; Hässler, F; Kelly, B; Kyle, RL; Patterson, AE; Pearce, EJ; Pearce, EL; Puleston, DJ; Sanin, DE1
Haluzik, M; Kizek, R; Knejzlik, Z; Krizova, E; Krizova, I; Rayova, D; Rimpelova, S; Rumlova, M; Sestakova, S; Skop, V; Svoboda, P; Sykora, D; Vapenkova, K; Volfova, N; Zidek, V; Zidkova, J1
Chen, C; Hu, Y; Huang, X; Shen, D; Xing, S1
Ito, K; Ito, S; Kawai, M; Kudo, K; Morita, M; Nomura, M; Sakamoto, Y; Shima, H; Tanuma, N; Yaegashi, N; Yamada, H; Yamashita, Y1
Elnenaei, MO; Gujar, SA; Kennedy, BE; Reiman, A; Sadek, M1
Effenberger, M; Gerner, RR; Grabherr, F; Kircher, B; Macheiner, S; Mayr, L; Moschen, AR; Moser, P; Nachbaur, D; Oberacher, H; Reider, S; Schwaighofer, H; Siegmund, K; Texler, B; Tilg, H; Zeiser, R1
Chen, J; Guo, C; Li, X; Qi, L; Wang, J; Ye, C; Yu, J; Zheng, S; Zhou, B1
Alhumaydhi, FA; Aljohani, ASM; Bordin, DL; Charlier, CF; de O Lopes, D; Elliott, RM; Henriques, JAP; Lloyd, CB; McNicholas, MD; Meira, LB; Milano, L; Plant, KE; Villela, I1
Cahill, DP; Kirtane, AR; Kiyokawa, J; Lee, CK; Li, M; Lopes, A; Nagashima, H; Tirmizi, ZA; Traverso, G; Wakimoto, H1
Bovée, JVMG; Bruijn, IB; Cleton-Jansen, AM; Franceschini, N; Kruisselbrink, AB; Niessen, B; Oosting, J; Palubeckaitė, I; Tamsma, M; van den Akker, B1
Dong, G; Guo, M; Sheng, C; Wang, W; Xu, D; Zhang, P; Zhou, L1

Reviews

3 review(s) available for nad and fk 866

ArticleYear
Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery.
    Expert opinion on therapeutic targets, 2007, Volume: 11, Issue:5

    Topics: Acrylamides; Adenosine Diphosphate Ribose; Aging; Animals; Antineoplastic Agents; Autoimmune Diseases; Clinical Trials, Phase II as Topic; Cyclic ADP-Ribose; DNA Damage; Drug Design; Enzyme Inhibitors; Humans; Kynurenine; Mice; NAD; Neoplasms; Neurodegenerative Diseases; Neuroprotective Agents; Piperidines; Poly Adenosine Diphosphate Ribose; Signal Transduction; Sirtuins; Tryptophan

2007
Nampt/PBEF/visfatin and cancer.
    Cancer biology & therapy, 2010, Jul-15, Volume: 10, Issue:2

    Topics: Acrylamides; Cytokines; Disease Progression; Humans; NAD; Neoplasms; Nicotinamide Phosphoribosyltransferase; Piperidines; Signal Transduction

2010
Pancreatic Cancer Metabolism: Molecular Mechanisms and Clinical Applications.
    Current oncology reports, 2018, 05-11, Volume: 20, Issue:7

    Topics: Acrylamides; Adenocarcinoma; Antineoplastic Agents; Citric Acid Cycle; Glutaminase; Glutamine; Humans; Mitochondria; Molecular Targeted Therapy; NAD; NAD(P)H Dehydrogenase (Quinone); Pancreatic Neoplasms; Piperidines

2018

Trials

2 trial(s) available for nad and fk 866

ArticleYear
The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor.
    Investigational new drugs, 2008, Volume: 26, Issue:1

    Topics: Acrylamides; Adult; Aged; Area Under Curve; Dose-Response Relationship, Drug; Fatigue; Female; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; NAD; Nausea; Neoplasms; Neutropenia; Nicotinamide Phosphoribosyltransferase; Piperidines; Thrombocytopenia; Vascular Endothelial Growth Factor A; Vomiting

2008
Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data.
    Cancer chemotherapy and pharmacology, 2010, Volume: 65, Issue:6

    Topics: Acrylamides; Aged; Clinical Trials, Phase I as Topic; Cyanides; Dose-Response Relationship, Drug; Drug Administration Schedule; Fatigue; Female; Guanidines; Humans; Male; Meta-Analysis as Topic; Middle Aged; NAD; Nausea; Neoplasms; Nicotinamide Phosphoribosyltransferase; Piperidines; Thrombocytopenia; Treatment Outcome; Vomiting

2010

Other Studies

86 other study(ies) available for nad and fk 866

ArticleYear
FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis.
    Cancer research, 2003, Nov-01, Volume: 63, Issue:21

    Topics: Acrylamides; Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Enzyme Inhibitors; Humans; K562 Cells; Kinetics; Liver Neoplasms; Mitochondria, Liver; NAD; Niacin; Niacinamide; Nicotinamide Phosphoribosyltransferase; Oxygen Consumption; Pentosyltransferases; Piperidines

2003
Metabolic signatures associated with a NAD synthesis inhibitor-induced tumor apoptosis identified by 1H-decoupled-31P magnetic resonance spectroscopy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, May-01, Volume: 11, Issue:9

    Topics: Acrylamides; Animals; Annexin A5; Apoptosis; Cell Cycle; Glycolysis; Guanine Nucleotides; Hydrogen-Ion Concentration; Intracellular Membranes; Magnetic Resonance Spectroscopy; Male; Mammary Neoplasms, Experimental; Membrane Potentials; Mice; Mice, Inbred C3H; Mitochondria; Mitosis; NAD; NADP; Neoplasm Transplantation; Nicotinamide Phosphoribosyltransferase; Pentosyltransferases; Phospholipids; Piperidines; Protein Binding; Time Factors

2005
Chemopotentiating effects of a novel NAD biosynthesis inhibitor, FK866, in combination with antineoplastic agents.
    European journal of medical research, 2006, Aug-30, Volume: 11, Issue:8

    Topics: Acrylamides; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Cell Death; Cell Line, Tumor; Cell Survival; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Drug Combinations; Humans; K562 Cells; Leukemia, Myeloid, Acute; Melphalan; Methylnitronitrosoguanidine; Monocytes; NAD; Piperidines

2006
Characterization of NAD uptake in mammalian cells.
    The Journal of biological chemistry, 2008, Mar-07, Volume: 283, Issue:10

    Topics: Acrylamides; Animals; Biological Transport; Cell Death; Dose-Response Relationship, Drug; HeLa Cells; Homeostasis; Humans; K562 Cells; Mice; NAD; NADP; NIH 3T3 Cells; Piperidines; Signal Transduction

2008
Anticancer agent CHS-828 inhibits cellular synthesis of NAD.
    Biochemical and biophysical research communications, 2008, Mar-21, Volume: 367, Issue:4

    Topics: Acrylamides; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cyanides; Dose-Response Relationship, Drug; Guanidines; Humans; Lung Neoplasms; NAD; Piperidines; Signal Transduction

2008
NAD depletion by FK866 induces autophagy.
    Autophagy, 2008, Volume: 4, Issue:3

    Topics: Acrylamides; Antineoplastic Agents; Apoptosis Inducing Factor; Autophagy; Caspase 3; Cell Death; Cell Line, Tumor; Cell Membrane; Cytochromes c; Enzyme Activation; Humans; Lysosomes; Microtubule-Associated Proteins; NAD; Piperidines

2008
Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage.
    ChemMedChem, 2008, Volume: 3, Issue:5

    Topics: Acrylamides; Antineoplastic Agents; Catalysis; Cell Line, Tumor; Cell Survival; Copper; Humans; NAD; Piperidines; Triazoles

2008
Weak coupling of ATP hydrolysis to the chemical equilibrium of human nicotinamide phosphoribosyltransferase.
    Biochemistry, 2008, Oct-21, Volume: 47, Issue:42

    Topics: Acrylamides; Adenosine Triphosphate; Cytokines; Enzyme Inhibitors; Enzyme Stability; Humans; Hydrolysis; In Vitro Techniques; Kinetics; Models, Biological; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Phosphorylation; Piperidines; Recombinant Proteins; Thermodynamics

2008
The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies.
    Blood, 2009, Apr-02, Volume: 113, Issue:14

    Topics: Acrylamides; Animals; Antineoplastic Agents; Cell Death; Cytokines; Dose-Response Relationship, Drug; Hematologic Neoplasms; HL-60 Cells; Humans; Jurkat Cells; K562 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Tumor Cells, Cultured; U937 Cells; Xenograft Model Antitumor Assays

2009
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1.
    Science (New York, N.Y.), 2009, May-01, Volume: 324, Issue:5927

    Topics: Acrylamides; Animals; ARNTL Transcription Factors; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Cell Line; Chromatin Assembly and Disassembly; Circadian Rhythm; CLOCK Proteins; Cytokines; Enzyme Inhibitors; Feedback, Physiological; Gene Expression Regulation; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Promoter Regions, Genetic; Sirtuin 1; Sirtuins; Trans-Activators; Transcription, Genetic

2009
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis.
    Science (New York, N.Y.), 2009, May-01, Volume: 324, Issue:5927

    Topics: Acrylamides; Adipose Tissue, White; Animals; ARNTL Transcription Factors; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Circadian Rhythm; CLOCK Proteins; Cytokines; Enzyme Inhibitors; Feedback, Physiological; Gene Expression Regulation; Hepatocytes; Humans; Liver; Mice; NAD; Nicotinamide Phosphoribosyltransferase; Nuclear Proteins; Period Circadian Proteins; Piperidines; Protein Binding; Sirtuin 1; Sirtuins; Trans-Activators; Transcription Factors; Transcription, Genetic

2009
Circadian rhythms. A circadian loop asSIRTs itself.
    Science (New York, N.Y.), 2009, May-01, Volume: 324, Issue:5927

    Topics: Acetylation; Acrylamides; Animals; ARNTL Transcription Factors; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Circadian Rhythm; CLOCK Proteins; Cytokines; Feedback, Physiological; Gene Expression Regulation; Mice; Mutation; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Sirtuin 1; Sirtuins; Trans-Activators; Transcription Factors; Transcription, Genetic

2009
Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo.
    Biochemical pharmacology, 2009, May-15, Volume: 77, Issue:10

    Topics: Acetophenones; Acrylamides; Animals; Cell Survival; Chromatography, High Pressure Liquid; Cytokines; Enzyme Inhibitors; Formates; HeLa Cells; Humans; Male; Mice; NAD; Niacinamide; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Organ Specificity; Piperidines; U937 Cells

2009
Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.
    PloS one, 2009, Nov-19, Volume: 4, Issue:11

    Topics: Acrylamides; Adenosine Triphosphate; Animals; Autophagy; Cell Proliferation; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Interferon-gamma; Jurkat Cells; Lymphocyte Activation; Membrane Potentials; Mice; Mice, Inbred C57BL; Myelin Sheath; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Poly(ADP-ribose) Polymerases; T-Lymphocytes; Tumor Necrosis Factor-alpha

2009
A preclinical study on the rescue of normal tissue by nicotinic acid in high-dose treatment with APO866, a specific nicotinamide phosphoribosyltransferase inhibitor.
    Molecular cancer therapeutics, 2010, Volume: 9, Issue:6

    Topics: Acrylamides; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cell Death; Cell Line, Tumor; Cytoprotection; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Humans; Maximum Tolerated Dose; Mice; NAD; Niacin; Nicotinamide Phosphoribosyltransferase; Organ Specificity; Piperidines; RNA, Messenger; Substrate Specificity; Xenograft Model Antitumor Assays

2010
Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells.
    Experimental hematology, 2010, Volume: 38, Issue:11

    Topics: Acrylamides; Adenosine Triphosphate; Aged; Apoptosis; Autophagy; Caspase 3; Cell Line, Tumor; Cells, Cultured; Cytokines; Drug Synergism; Female; Humans; Immunoblotting; Jurkat Cells; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Male; Membrane Potential, Mitochondrial; Middle Aged; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand; Tubulin

2010
Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool.
    The Journal of biological chemistry, 2010, Oct-29, Volume: 285, Issue:44

    Topics: Acrylamides; Adenosine Triphosphate; Animals; Enzyme Inhibitors; Fibroblasts; HeLa Cells; Humans; Kynurenine; Male; Mice; Mitochondria; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Poly(ADP-ribose) Polymerases

2010
Overcoming temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repair.
    Cancer research, 2011, Mar-15, Volume: 71, Issue:6

    Topics: Acrylamides; Adenosine Triphosphate; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Survival; Dacarbazine; DNA Glycosylases; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Glioblastoma; Humans; Hydroxylamines; Immunoblotting; Methyl Methanesulfonate; NAD; Piperidines; Poly(ADP-ribose) Polymerases; RNA Interference; Temozolomide

2011
Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells.
    PloS one, 2011, Volume: 6, Issue:7

    Topics: Acrylamides; Antigens, CD34; bcl-2-Associated X Protein; Cell Death; Cell Line, Tumor; Drug Screening Assays, Antitumor; Drug Synergism; Gene Silencing; Histone Deacetylase Inhibitors; Humans; Leukemia; NAD; Piperidines; Sirtuins; Up-Regulation

2011
Inhibition of nicotinamide phosphoribosyltransferase modifies LPS-induced inflammatory responses of human monocytes.
    Innate immunity, 2012, Volume: 18, Issue:3

    Topics: Acrylamides; ADP-ribosyl Cyclase 1; Apoptosis; Cells, Cultured; Eicosanoids; Humans; Inflammation; Inflammation Mediators; Lipopolysaccharides; Monocytes; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Protein Processing, Post-Translational; Reactive Oxygen Species; Tumor Necrosis Factor-alpha; Up-Regulation

2012
Pre-B-cell colony-enhancing factor exerts a neuronal protection through its enzymatic activity and the reduction of mitochondrial dysfunction in in vitro ischemic models.
    Journal of neurochemistry, 2012, Volume: 120, Issue:2

    Topics: Acrylamides; Animals; Brain; Cell Death; Cells, Cultured; DNA, Mitochondrial; Embryo, Mammalian; Female; Glucose; Glutamic Acid; Hypoxia; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; Mutation; NAD; Neurons; Neuroprotective Agents; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Pregnancy

2012
Anti-proliferation effect of APO866 on C6 glioblastoma cells by inhibiting nicotinamide phosphoribosyltransferase.
    European journal of pharmacology, 2012, Jan-15, Volume: 674, Issue:2-3

    Topics: Acrylamides; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Intracellular Space; M Phase Cell Cycle Checkpoints; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Rats

2012
NAMPT pathway is involved in the FOXO3a-mediated regulation of GADD45A expression.
    Biochemical and biophysical research communications, 2012, Apr-20, Volume: 420, Issue:4

    Topics: Acetylation; Acrylamides; Apoptosis; Cell Cycle Proteins; Cytokines; Forkhead Box Protein O3; Forkhead Transcription Factors; HEK293 Cells; Humans; NAD; Nicotinamide Phosphoribosyltransferase; Nuclear Proteins; Piperidines; RNA, Messenger; Sirtuin 1

2012
Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction.
    Antioxidants & redox signaling, 2013, Feb-20, Volume: 18, Issue:6

    Topics: Acrylamides; Animals; Chemokine CXCL2; Humans; Male; Mice; Myocardial Infarction; Myocardial Reperfusion Injury; NAD; Neutrophil Infiltration; Nicotinamide Phosphoribosyltransferase; Oxidative Stress; Piperidines; Reactive Oxygen Species; Signal Transduction

2013
NAD+ levels control Ca2+ store replenishment and mitogen-induced increase of cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes.
    The Journal of biological chemistry, 2012, Jun-15, Volume: 287, Issue:25

    Topics: Acrylamides; Calcium; Calcium Signaling; Cell Proliferation; Cyclic ADP-Ribose; Cytokines; Enzyme Inhibitors; Humans; Interleukin-2; Ion Channel Gating; Jurkat Cells; Mitogens; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; T-Lymphocytes; Thapsigargin; TRPM Cation Channels

2012
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
    The Journal of biological chemistry, 2012, Jul-06, Volume: 287, Issue:28

    Topics: Acrylamides; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; AMP-Activated Protein Kinases; Animals; Blotting, Western; Carbazoles; Cell Line, Tumor; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; HEK293 Cells; Hep G2 Cells; Humans; Mice; Mice, Knockout; Models, Biological; Mutation; NAD; Niacinamide; Phosphorylation; Piperidines; Resveratrol; RNA Interference; Signal Transduction; Sirtuin 1; Stilbenes

2012
Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells.
    International journal of cancer, 2013, Feb-15, Volume: 132, Issue:4

    Topics: Acetylation; Acrylamides; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cytokines; Gene Knockout Techniques; Humans; Leukemia, Myeloid; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Sirtuins; Tumor Suppressor Protein p53; Up-Regulation

2013
Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.
    Blood, 2012, Oct-25, Volume: 120, Issue:17

    Topics: Acrylamides; Animals; Antineoplastic Agents; Autophagy; Cell Line, Tumor; Cell Survival; Cytokines; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Mechanistic Target of Rapamycin Complex 1; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Targeted Therapy; Multiple Myeloma; Multiprotein Complexes; NAD; Nicotinamide Phosphoribosyltransferase; Organ Specificity; Piperidines; Proteins; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays

2012
Nicotinamide phosphoribosyltransferase may be involved in age-related brain diseases.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Acrylamides; Aging; Animals; Brain Diseases; Cerebellum; Corpus Striatum; Female; Hippocampus; Mice; NAD; Neurons; Nicotinamide Phosphoribosyltransferase; Piperidines; Rats

2012
Intracellular NAD(+) depletion induces autophagic death in multiple myeloma cells.
    Autophagy, 2013, Volume: 9, Issue:3

    Topics: Acrylamides; Apoptosis; Autophagy; Cell Death; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Gene Transfer Techniques; Humans; Lentivirus; Multiple Myeloma; NAD; Piperidines; Transcription, Genetic

2013
Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications.
    The Journal of biological chemistry, 2013, Feb-01, Volume: 288, Issue:5

    Topics: Acrylamides; Adenosine Triphosphate; Animals; Carbon Isotopes; Cell Death; Cell Line, Tumor; Citric Acid Cycle; Enzyme Inhibitors; Female; Glycolysis; Humans; Isotope Labeling; Mice; Mice, SCID; NAD; Neoplasms; Nicotinamide Phosphoribosyltransferase; Pentose Phosphate Pathway; Piperidines; Serine; Xenograft Model Antitumor Assays

2013
Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression.
    The Journal of clinical investigation, 2013, Volume: 123, Issue:3

    Topics: Acrylamides; Animals; Autophagy; Autophagy-Related Protein 5; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytokines; Disease Progression; Electron Transport Complex I; Female; Gene Knockdown Techniques; Humans; Lung Neoplasms; Mammary Neoplasms, Experimental; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred BALB C; Mice, SCID; Microtubule-Associated Proteins; Mitochondria; Multiprotein Complexes; NAD; Neoplasm Transplantation; Niacin; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Protein Transport; Proteins; Recombinant Proteins; Saccharomyces cerevisiae Proteins; TOR Serine-Threonine Kinases

2013
NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity.
    Experimental hematology, 2013, Volume: 41, Issue:6

    Topics: Acrylamides; Animals; Bone and Bones; Cell Differentiation; Coculture Techniques; Cytokines; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Mice; Mice, SCID; Multiple Myeloma; NAD; Neoplasm Proteins; NF-kappa B; Niacinamide; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Osteoclasts; Osteolysis; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Rabbits; Sirtuin 1; Tumor Cells, Cultured; Up-Regulation

2013
Intracellular NAD⁺ depletion enhances bortezomib-induced anti-myeloma activity.
    Blood, 2013, Aug-15, Volume: 122, Issue:7

    Topics: Acrylamides; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Biomarkers, Tumor; Blotting, Western; Boronic Acids; Bortezomib; Case-Control Studies; Caspases; Cell Proliferation; Drug Synergism; Female; Fluorescent Antibody Technique; Gene Expression Profiling; Humans; Male; Mice; Mice, SCID; Multiple Myeloma; NAD; Neoplasm Recurrence, Local; NF-kappa B; Nicotinamide Phosphoribosyltransferase; Oligonucleotide Array Sequence Analysis; Piperidines; Poly(ADP-ribose) Polymerases; Prognosis; Pyrazines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2013
CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells.
    The Journal of biological chemistry, 2013, Sep-06, Volume: 288, Issue:36

    Topics: 5'-Nucleotidase; Acrylamides; ADP-ribosyl Cyclase 1; Cell Death; Cell Line, Tumor; Cytokines; Down-Regulation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Silencing; GPI-Linked Proteins; Humans; Membrane Glycoproteins; NAD; Neoplasm Proteins; Neoplasms; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Piperidines

2013
Targeting of NAD metabolism in pancreatic cancer cells: potential novel therapy for pancreatic tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Jan-01, Volume: 20, Issue:1

    Topics: Acrylamides; ADP-ribosyl Cyclase 1; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytokines; Female; Humans; Membrane Glycoproteins; Mice; Mice, Nude; Molecular Targeted Therapy; NAD; Nicotinamide Phosphoribosyltransferase; Pancreatic Neoplasms; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Sirtuin 1; Tumor Burden; Xenograft Model Antitumor Assays

2014
Targeting metabolic scavenging in pancreatic cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Jan-01, Volume: 20, Issue:1

    Topics: Acrylamides; Animals; Antineoplastic Agents; Female; Humans; NAD; Pancreatic Neoplasms; Piperidines

2014
Hepatectomy-related hypophosphatemia: a novel phosphaturic factor in the liver-kidney axis.
    Journal of the American Society of Nephrology : JASN, 2014, Volume: 25, Issue:4

    Topics: Acrylamides; Animals; Hepatectomy; Hypophosphatemia; Kidney; Male; Mice; Mice, Inbred C57BL; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Parathyroidectomy; Piperidines; Rats; Rats, Wistar; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type IIa

2014
Nicotinamide phosphoribosyltransferase (NAMPT) activity is essential for survival of resting lymphocytes.
    Immunology and cell biology, 2014, Volume: 92, Issue:2

    Topics: Acrylamides; Animals; Apoptosis; Cell Survival; Cytokines; Humans; Male; Mice; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases

2014
The anti-lymphoma activity of APO866, an inhibitor of nicotinamide adenine dinucleotide biosynthesis, is potentialized when used in combination with anti-CD20 antibody.
    Leukemia & lymphoma, 2014, Volume: 55, Issue:9

    Topics: Acrylamides; Animals; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Apoptosis; Biosynthetic Pathways; Caspase 3; Cell Line, Tumor; Disease Models, Animal; Drug Synergism; Humans; Lymphoma; Membrane Potential, Mitochondrial; Mice; Mice, SCID; NAD; Piperidines; Reactive Oxygen Species; Rituximab; Xenograft Model Antitumor Assays

2014
Endogenous NAMPT dampens chemokine expression and apoptotic responses in stressed tubular cells.
    Biochimica et biophysica acta, 2014, Volume: 1842, Issue:2

    Topics: Acrylamides; Animals; Apoptosis; Blotting, Western; Cell Line; Chemokine CCL2; Chemokine CCL5; Chemokines; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Epithelial Cells; Gene Expression; Humans; Immunohistochemistry; Interleukin-6; Kidney; Kidney Tubules, Proximal; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Rats; Rats, Inbred WKY; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tumor Necrosis Factor-alpha

2014
NAD⁺ depletion by APO866 in combination with radiation in a prostate cancer model, results from an in vitro and in vivo study.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2014, Volume: 110, Issue:2

    Topics: Acrylamides; Animals; Cell Growth Processes; Cell Line, Tumor; Cell Survival; Chemoradiotherapy; Female; Humans; Male; Mice; Mice, Inbred BALB C; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Prostatic Neoplasms; Radiation-Sensitizing Agents; Xenograft Model Antitumor Assays

2014
A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis.
    Autophagy, 2014, Volume: 10, Issue:4

    Topics: Acrylamides; Apoptosis; Autophagy; Caspase 3; Cell Line, Tumor; Humans; Leukemia; Lymphoma; NAD; Piperidines; Reactive Oxygen Species

2014
Nicotinamide phosphoribosyltransferase inhibitor is a novel therapeutic candidate in murine models of inflammatory lung injury.
    American journal of respiratory cell and molecular biology, 2014, Volume: 51, Issue:2

    Topics: Acrylamides; Animals; Anti-Inflammatory Agents; Apoptosis; Bronchoalveolar Lavage Fluid; Caspase 3; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Inflammation Mediators; Lung; Mice; Mice, Inbred C57BL; NAD; Neutrophils; Nicotinamide Phosphoribosyltransferase; Piperidines; Pneumonia; Respiratory Distress Syndrome; Ventilator-Induced Lung Injury

2014
Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels.
    DNA repair, 2014, Volume: 23

    Topics: Acetylation; Acrylamides; Enzyme Inhibitors; HEK293 Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lysine; NAD; Phenanthrenes; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Sirtuin 2; Tubulin

2014
NAMPT-mediated salvage synthesis of NAD+ controls morphofunctional changes of macrophages.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Acrylamides; Actin Cytoskeleton; Adenosine Triphosphate; Blotting, Western; Cell Line; Cytokines; DNA Primers; Fluorescence; Humans; Macrophages; Microscopy, Electron, Scanning; NAD; Nicotinamide Phosphoribosyltransferase; Oxidation-Reduction; Oxygen Consumption; Phagocytosis; Piperidines; Transfection

2014
Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Jul-15, Volume: 111, Issue:28

    Topics: Acrylamides; Animals; Cells, Cultured; Cerebral Cortex; Enzyme Activation; Glucose; Glucose-6-Phosphate; Glycolysis; Hexokinase; Methylnitronitrosoguanidine; Mice; Mitochondria; NAD; Nerve Tissue Proteins; Neurons; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases

2014
Up-regulation of nicotinamide phosphoribosyltransferase and increase of NAD+ levels by glucose restriction extend replicative lifespan of human fibroblast Hs68 cells.
    Biogerontology, 2015, Volume: 16, Issue:1

    Topics: Acrylamides; Benzamides; Cell Line; Cell Proliferation; Cell Survival; Cells, Cultured; Cellular Senescence; Cytokines; Dose-Response Relationship, Drug; Fibroblasts; Glucose; Humans; NAD; Naphthols; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Sirtuin 1; Up-Regulation

2015
Pre-B cell colony enhancing factor induces Nampt-dependent translocation of the insulin receptor out of lipid microdomains in A549 lung epithelial cells.
    American journal of physiology. Endocrinology and metabolism, 2015, Feb-15, Volume: 308, Issue:4

    Topics: Acrylamides; Antigens, CD; Caveolin 1; Cell Line; Cytokines; Enzyme Inhibitors; Humans; Insulin; Insulin Resistance; Lung; Membrane Microdomains; NAD; Nicotinamide Phosphoribosyltransferase; Phosphorylation; Piperidines; Protein Processing, Post-Translational; Protein Transport; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Recombinant Proteins; Respiratory Mucosa; Signal Transduction

2015
NAMPT inhibitor and metabolite protect mouse brain from cryoinjury through distinct mechanisms.
    Neuroscience, 2015, Apr-16, Volume: 291

    Topics: Acrylamides; Acute Disease; Animals; Astrocytes; Brain; Brain Injuries; Calcium-Binding Proteins; Cell Count; Chronic Disease; Cold Temperature; Cytokines; Disease Models, Animal; Macrophages; Male; Mice, Inbred BALB C; Microfilament Proteins; Microglia; NAD; Neurons; Neuroprotective Agents; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Piperidines

2015
Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: 3T3 Cells; Acrylamides; Adenosine Triphosphate; Animals; Catalysis; Energy Metabolism; Glucose; HEK293 Cells; Humans; Insulinoma; Mice; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Rats; Tankyrases; Ubiquitin

2015
Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, Leads to Altered Carbohydrate Metabolism in Cancer Cells.
    The Journal of biological chemistry, 2015, Jun-19, Volume: 290, Issue:25

    Topics: Acrylamides; Carbohydrate Metabolism; Cytokines; Enzyme Inhibitors; Humans; Mass Spectrometry; NAD; Neoplasm Proteins; Neoplasms; Nicotinamide Phosphoribosyltransferase; Piperidines; Sugar Phosphates

2015
APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Sep-01, Volume: 21, Issue:17

    Topics: Acrylamides; Adenosine Triphosphate; Aged; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cell Survival; Chromosome Aberrations; Cyclosporine; Drug Resistance, Neoplasm; Drug Synergism; Endoplasmic Reticulum Stress; Female; Gene Expression; Humans; Immunoglobulin Heavy Chains; Leukemia; Male; Membrane Potential, Mitochondrial; Middle Aged; Mitochondria; Mutation; NAD; Neoplasm Staging; Niacin; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Primary Cell Culture; Prognosis; Tumor Cells, Cultured; Unfolded Protein Response

2015
FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes.
    Biochemical pharmacology, 2015, Nov-01, Volume: 98, Issue:1

    Topics: Acrylamides; Animals; Cells, Cultured; Cytokines; Gene Expression Regulation; Hydrogen Peroxide; Insulin; Mitochondria; Myocytes, Cardiac; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Norepinephrine; Piperidines; Rats; Stress, Physiological

2015
A Nampt inhibitor FK866 mimics vitamin B3 deficiency by causing senescence of human fibroblastic Hs68 cells via attenuation of NAD(+)-SIRT1 signaling.
    Biogerontology, 2015, Volume: 16, Issue:6

    Topics: Acrylamides; AMP-Activated Protein Kinases; Cell Line; Cell Proliferation; Cellular Senescence; Cytokines; Enzyme Inhibitors; Fibroblasts; Glutathione; Humans; NAD; NADP; Niacin; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Signal Transduction; Sirtuin 1; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53

2015
EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition.
    BMC cancer, 2015, Nov-05, Volume: 15

    Topics: Acrylamides; Adenosine Triphosphate; AMP-Activated Protein Kinases; Apoptosis; Caspases; Cell Line, Tumor; Cell Survival; Cytokines; Drug Resistance, Neoplasm; Eukaryotic Initiation Factor-2; Eukaryotic Initiation Factor-4E; Humans; Jurkat Cells; Leukemia; NAD; Nicotinamide Phosphoribosyltransferase; Phosphorylation; Piperidines; Protein Biosynthesis; Signal Transduction; Stress, Physiological; TOR Serine-Threonine Kinases; Transcription, Genetic

2015
NAMPT suppresses glucose deprivation-induced oxidative stress by increasing NADPH levels in breast cancer.
    Oncogene, 2016, 07-07, Volume: 35, Issue:27

    Topics: Acrylamides; Animals; Blotting, Western; Breast Neoplasms; Cell Hypoxia; Cell Line; Cell Line, Tumor; Cytokines; Female; Glucose; HCT116 Cells; Humans; Mice, Inbred BALB C; Mice, Nude; NAD; NADP; Nicotinamide Phosphoribosyltransferase; Oxidative Stress; Piperidines; Reactive Oxygen Species; RNA Interference; Xenograft Model Antitumor Assays

2016
IDO Downregulation Induces Sensitivity to Pemetrexed, Gemcitabine, FK866, and Methoxyamine in Human Cancer Cells.
    PloS one, 2015, Volume: 10, Issue:11

    Topics: Acrylamides; Animals; BRCA2 Protein; Cell Line, Tumor; Clone Cells; Deoxycytidine; DNA Repair; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Induction; Floxuridine; Gemcitabine; Gene Knockdown Techniques; Humans; Hydroxylamines; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice, SCID; NAD; Pemetrexed; Piperidines; RNA, Small Interfering; Thymidylate Synthase; Xenograft Model Antitumor Assays

2015
Nicotinamide phosphoribosyltransferase inhibitor APO866 induces C6 glioblastoma cell death via autophagy.
    Die Pharmazie, 2015, Volume: 70, Issue:10

    Topics: Acrylamides; Animals; Autophagy; Cell Death; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Glioblastoma; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Rats; Vacuoles

2015
Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model.
    Oncotarget, 2016, Jan-19, Volume: 7, Issue:3

    Topics: 5'-Nucleotidase; Acrylamides; Adenosine Triphosphate; Animals; Cell Line, Tumor; Cytokines; Female; GPI-Linked Proteins; Humans; Mice; Mice, Nude; NAD; Niacinamide; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Ovarian Neoplasms; Piperidines; Pyridinium Compounds; RNA Interference; RNA, Small Interfering

2016
Regulation of the Nampt-mediated NAD salvage pathway and its therapeutic implications in pancreatic cancer.
    Cancer letters, 2016, 08-28, Volume: 379, Issue:1

    Topics: 3' Untranslated Regions; Acrylamides; Animals; Antimetabolites, Antineoplastic; Binding Sites; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cytokines; Deoxycytidine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Gemcitabine; Glycolysis; Humans; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; MicroRNAs; NAD; Nicotinamide Phosphoribosyltransferase; Pancreatic Neoplasms; Piperidines; RNA Interference; Time Factors; Transfection; Tumor Burden; Xenograft Model Antitumor Assays

2016
EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells.
    Oncotarget, 2017, Apr-11, Volume: 8, Issue:15

    Topics: Acrylamides; Bone Neoplasms; Cell Line, Tumor; Cytokines; Drug Resistance, Neoplasm; Enzyme Inhibitors; HeLa Cells; Humans; NAD; Nicotinamide Phosphoribosyltransferase; Oncogene Proteins, Fusion; Piperidines; Proto-Oncogene Protein c-fli-1; RNA-Binding Protein EWS; Sarcoma, Ewing

2017
Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway.
    Lipids in health and disease, 2017, Apr-27, Volume: 16, Issue:1

    Topics: Acrylamides; AMP-Activated Protein Kinases; Animals; Carbazoles; Cell Line; Cytokines; Diet, High-Fat; Enzyme Inhibitors; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Liver; Male; Mice; Mice, Inbred C57BL; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Non-alcoholic Fatty Liver Disease; Oleic Acid; Piperidines; Resveratrol; Signal Transduction; Sirtuin 1; Sterol Regulatory Element Binding Protein 1; Stilbenes

2017
The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in
    Cancer research, 2017, 08-01, Volume: 77, Issue:15

    Topics: Acrylamides; Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Dacarbazine; Enzyme Inhibitors; Female; Glioma; Humans; Isocitrate Dehydrogenase; Mice; Mice, SCID; Mutation; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Random Allocation; Stress, Physiological; Temozolomide; Xenograft Model Antitumor Assays

2017
Inhibition of NAMPT decreases cell growth and enhances susceptibility to oxidative stress.
    Oncology reports, 2017, Volume: 38, Issue:3

    Topics: A549 Cells; Acrylamides; Antioxidants; Catalase; Cell Line; Cell Line, Tumor; Cell Proliferation; Cytokines; DNA Repair; Down-Regulation; Glutaredoxins; HEK293 Cells; Humans; NAD; Nicotinamide Phosphoribosyltransferase; Oxidative Stress; Piperidines; Poly (ADP-Ribose) Polymerase-1; Proliferating Cell Nuclear Antigen; Ribosomal Proteins

2017
Extracellular NAMPT/visfatin causes p53 deacetylation via NAD production and SIRT1 activation in breast cancer cells.
    Cell biochemistry and function, 2017, Volume: 35, Issue:6

    Topics: Acrylamides; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Humans; MCF-7 Cells; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Recombinant Proteins; Sirtuin 1; Tumor Suppressor Protein p53; Up-Regulation

2017
NAD metabolism fuels human and mouse intestinal inflammation.
    Gut, 2018, Volume: 67, Issue:10

    Topics: Acrylamides; Animals; Cell Differentiation; Colitis, Ulcerative; Colonic Neoplasms; Dexamethasone; Energy Metabolism; Gastrointestinal Agents; Humans; Infliximab; Intestinal Mucosa; Macrophages; Mice; Monocytes; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines

2018
Oleate ameliorates palmitate-induced reduction of NAMPT activity and NAD levels in primary human hepatocytes and hepatocarcinoma cells.
    Lipids in health and disease, 2017, Oct-03, Volume: 16, Issue:1

    Topics: Acrylamides; Apoptosis; Cell Survival; Cytokines; Enzyme Inhibitors; Gene Expression; Hep G2 Cells; Hepatocytes; Humans; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Oleic Acid; Palmitic Acid; Piperidines; Primary Cell Culture; RNA, Messenger

2017
Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy.
    Circulation, 2018, 05-22, Volume: 137, Issue:21

    Topics: Acrylamides; AMP-Activated Protein Kinases; Animals; Cardiomyopathy, Dilated; Citric Acid; Cytokines; Dietary Supplements; Disease Models, Animal; Gene Expression Profiling; Heart Failure; Metabolome; Mice; Mice, Transgenic; Myocytes, Cardiac; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Phosphotransferases (Alcohol Group Acceptor); Piperidines; PPAR alpha; Pyridinium Compounds; Rats; Serum Response Factor

2018
ROS-Mediated 15-Hydroxyprostaglandin Dehydrogenase Degradation via Cysteine Oxidation Promotes NAD
    Cell chemical biology, 2018, 03-15, Volume: 25, Issue:3

    Topics: Acrylamides; ADP-ribosyl Cyclase 1; Autophagy; Cell Line, Tumor; Cell Movement; Cysteine; Dinoprostone; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Hydroxyprostaglandin Dehydrogenases; Membrane Glycoproteins; Mutagenesis, Site-Directed; NAD; Niacin; Oxidation-Reduction; Piperidines; Proteasome Endopeptidase Complex; Protein Stability; Reactive Oxygen Species; Sulfonic Acids

2018
Loss of NAMPT in aging retinal pigment epithelium reduces NAD
    Aging, 2018, Jun-12, Volume: 10, Issue:6

    Topics: Acrylamides; Aging; Animals; Cells, Cultured; Cytokines; Epithelial Cells; Gene Expression Regulation; Humans; Male; Mice; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Piperidines; Retinal Pigment Epithelium; Reverse Transcriptase Polymerase Chain Reaction

2018
Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition.
    Molecular & cellular proteomics : MCP, 2018, Volume: 17, Issue:10

    Topics: Acrylamides; ADP-ribosyl Cyclase 1; Animals; Cell Line; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; Humans; Integrins; Mice, Nude; NAD; Oxidative Stress; Piperidines; Proteome; Proteomics; Reactive Oxygen Species; Signal Transduction; STAT3 Transcription Factor

2018
CD38 Inhibits Prostate Cancer Metabolism and Proliferation by Reducing Cellular NAD
    Molecular cancer research : MCR, 2018, Volume: 16, Issue:11

    Topics: Acrylamides; ADP-ribosyl Cyclase 1; AMP-Activated Protein Kinase Kinases; Cell Line, Tumor; Cell Proliferation; Cellular Reprogramming; Cytokines; Fatty Acids; Gene Expression; Humans; Lipids; Male; Membrane Glycoproteins; Mitochondria; NAD; Nicotinamide Phosphoribosyltransferase; PC-3 Cells; Piperidines; Prostatic Neoplasms; Protein Kinases; Transcriptome; Transfection; Tretinoin

2018
Pharmacological bypass of NAD
    Proceedings of the National Academy of Sciences of the United States of America, 2018, 10-16, Volume: 115, Issue:42

    Topics: Acrylamides; Animals; Antineoplastic Agents, Phytogenic; Drug Combinations; Francisella tularensis; Ganglia, Spinal; NAD; Nerve Degeneration; Neurons; Niacinamide; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Piperidines; Pyridinium Compounds; Vincristine

2018
Nicotinamide Metabolism Modulates the Proliferation/Differentiation Balance and Senescence of Human Primary Keratinocytes.
    The Journal of investigative dermatology, 2019, Volume: 139, Issue:8

    Topics: 3T3 Cells; Acrylamides; Adult; Animals; Cell Differentiation; Cell Proliferation; Cellular Senescence; Cytokines; Female; Healthy Volunteers; Humans; Keratinocytes; Mice; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; Primary Cell Culture; Skin; Skin Aging; Stem Cells

2019
Inflammatory macrophage dependence on NAD
    Nature immunology, 2019, Volume: 20, Issue:4

    Topics: Acrylamides; Animals; Cells, Cultured; Cytokines; DNA Damage; Electron Transport Complex III; HEK293 Cells; Humans; Inflammation; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Mitochondria; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Reactive Oxygen Species

2019
Nuclear transport of nicotinamide phosphoribosyltransferase is cell cycle-dependent in mammalian cells, and its inhibition slows cell growth.
    The Journal of biological chemistry, 2019, 05-31, Volume: 294, Issue:22

    Topics: 3T3-L1 Cells; Acrylamides; Active Transport, Cell Nucleus; Animals; Cell Cycle Checkpoints; Cell Nucleus; Cell Proliferation; Cell Survival; Cytoplasm; Hep G2 Cells; Histones; Humans; Mice; Mutagenesis, Site-Directed; NAD; Nicotinamide Phosphoribosyltransferase; Oxidative Stress; Piperidines; Poly(ADP-ribose) Polymerases; Recombinant Fusion Proteins; Sirtuins

2019
Nicotinamide phosphoribosyltransferase‑related signaling pathway in early Alzheimer's disease mouse models.
    Molecular medicine reports, 2019, Volume: 20, Issue:6

    Topics: Acrylamides; Alzheimer Disease; Amyloid; Animals; Behavior, Animal; Cytokines; Disease Models, Animal; Hippocampus; Learning; Male; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Signal Transduction; Sirtuin 1

2019
Divergent metabolic responses dictate vulnerability to NAMPT inhibition in ovarian cancer.
    FEBS letters, 2020, Volume: 594, Issue:9

    Topics: Acrylamides; Cell Line, Tumor; Cytokines; Female; Glycolysis; Humans; Lactic Acid; NAD; Niacin; Nicotinamide Phosphoribosyltransferase; Ovarian Neoplasms; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors

2020
Targeting NAD
    Trends in cancer, 2020, Volume: 6, Issue:1

    Topics: Acrylamides; Adenosine; Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase 1; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cytokines; Drug Synergism; Humans; Membrane Glycoproteins; Multiple Myeloma; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Piperidines; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Regulatory; Tumor Escape; Warburg Effect, Oncologic

2020
Targeting NAD immunometabolism limits severe graft-versus-host disease and has potent antileukemic activity.
    Leukemia, 2020, Volume: 34, Issue:7

    Topics: Acrylamides; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Cytokines; Energy Metabolism; Female; Graft vs Host Disease; Humans; Immunologic Memory; Leukemia; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; T-Lymphocytes, Regulatory; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2020
Targeting the NAD
    Cell communication and signaling : CCS, 2020, 01-31, Volume: 18, Issue:1

    Topics: Acrylamides; Adenomatous Polyposis Coli Protein; Animals; Axin Protein; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Cytokines; Female; Gene Knockdown Techniques; Humans; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Mutation; NAD; Neoplasm Invasiveness; Nicotinamide Phosphoribosyltransferase; Piperidines; Prognosis; Wnt Signaling Pathway

2020
Alkyladenine DNA glycosylase deficiency uncouples alkylation-induced strand break generation from PARP-1 activation and glycolysis inhibition.
    Scientific reports, 2020, 02-10, Volume: 10, Issue:1

    Topics: Acrylamides; Alkylation; Animals; Cells, Cultured; Cytokines; DNA Breaks; DNA Glycosylases; DNA Repair; Fibroblasts; Glycolysis; Methyl Methanesulfonate; Mice; Mice, Knockout; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Poly (ADP-Ribose) Polymerase-1; Primary Cell Culture

2020
Local Targeting of NAD
    Cancer research, 2020, 11-15, Volume: 80, Issue:22

    Topics: Acrylamides; Animals; Autophagy; B7-H1 Antigen; Brain Neoplasms; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Movement; Cyanides; Cytokines; Delayed-Action Preparations; Drug Carriers; Glioblastoma; Guanidines; Humans; Injections, Intralesional; Macrophages; Membrane Proteins; Mice; NAD; Nicotinamide Phosphoribosyltransferase; Piperidines; Polymers; RNA, Messenger; Signal Transduction; Tumor Microenvironment; Up-Regulation

2020
Targeting the NAD Salvage Synthesis Pathway as a Novel Therapeutic Strategy for Osteosarcomas with Low NAPRT Expression.
    International journal of molecular sciences, 2021, Jun-10, Volume: 22, Issue:12

    Topics: Acrylamides; Apoptosis; Bone Neoplasms; Cell Proliferation; Gene Expression Regulation, Enzymologic; Glioma; Humans; NAD; Osteosarcoma; Pentosyltransferases; Piperidines; Tumor Cells, Cultured

2021
Discovery of potent NAMPT-Targeting PROTACs using FK866 as the warhead.
    Bioorganic & medicinal chemistry letters, 2023, 08-15, Volume: 92

    Topics: Cell Line, Tumor; Cytokines; Female; Humans; NAD; Nicotinamide Phosphoribosyltransferase; Ovarian Neoplasms; Proteolysis; Proteolysis Targeting Chimera

2023