nad has been researched along with aspartic acid in 250 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 139 (55.60) | 18.7374 |
| 1990's | 33 (13.20) | 18.2507 |
| 2000's | 41 (16.40) | 29.6817 |
| 2010's | 23 (9.20) | 24.3611 |
| 2020's | 14 (5.60) | 2.80 |
| Authors | Studies |
|---|---|
| Colman, RF; Ramachandran, N | 1 |
| Faulkner, A; Jones, CT | 1 |
| Viale, RO; Williamson, JR | 1 |
| Chen, JL; Tritz, GJ | 1 |
| Bremer, J; Davis, EJ | 1 |
| Johnson, RM; Yeh, YY | 1 |
| Cederbaum, AI; Rubin, E | 3 |
| Brody, S; Schmit, JC | 1 |
| Safer, B | 1 |
| Greenhouse, WV; Lehninger, AL | 2 |
| Buniatian, GKh | 2 |
| Clark, JB; Walsh, JM | 1 |
| Chen, J; Tritz, GJ | 1 |
| Dynnik, VV; Ovchinnikov, IA; Sel'kov, EE | 1 |
| Bartoli, GM; Dani, A; Galeotti, T | 1 |
| De Liberali, E; Eboli, ML; Galeotti, T; López-Alarcón, L; Palombini, G | 1 |
| Cronholm, T | 1 |
| Casciaro, A; Chiaretti, B; Eboli, ML; Galeotti, T; Minotti, G | 1 |
| Bookelman, H; Janssen, AJ; Sengers, RC; Stadhouders, AM; Trijbels, JM; Veerkamp, JH | 1 |
| Berdanier, CD; Caton, C; DeVore, V; Ecklund, RE; Tobin, RB | 1 |
| Gibson, J; Ihlenfeldt, MJ | 1 |
| Hindfelt, B | 1 |
| Chandler, JL; Gholson, RK; Griffith, GR | 1 |
| Matsuno, T | 2 |
| Berry, MN; Gregory, RB; Phillips, JW | 1 |
| Berry, MN; Grivell, AR; Phillips, JW | 1 |
| Berry, MN; Gregory, RB; Grivell, AR; Phillips, JW; Wallace, PG | 1 |
| Doré, JF; Goetsch, L; Hamedi-Sangsari, F; Malley, S; Navarro, C; Thomasset, N; Tournaire, R; Vila, J | 1 |
| Bray, T; Grimshaw, CE; Hoch, J; Matthews, DA; Skinner, M; Varughese, KI; Whiteley, JM; Xuong, NH | 1 |
| Chang, SH; Chen, Z; Lee, WR | 1 |
| Bray, T; Hoch, J; Matthews, DA; Schneider, M; Skinner, M; Trach, K; Varughese, KI; Whiteley, JM; Xuong, NH | 1 |
| Korpela, T; Kurkijärvi, K; Vierijoki, T | 1 |
| Aksamit, RR; Backlund, PS; Cantoni, GL; Date, T; Fujioka, M; Gomi, T; Takata, Y | 1 |
| Collier, RJ; Reich, KA; Weinstein, BR; Wilson, BA | 1 |
| Fan, F; Lorenzen, JA; Plapp, BV | 1 |
| Darnay, BG; Rodwell, VW; Wang, Y | 1 |
| Handler, JA; Kizaki, Z; Sugano, T; Thurman, RG; Yoshihara, H | 1 |
| Greenberg, JH; Karp, A; Reivich, M; Uematsu, D | 1 |
| Colman, RF; Huang, YC | 1 |
| Barbieri, JT; Collier, RJ; Tweten, RK | 1 |
| Chagoya de Sánchez, V; Díaz-Muñoz, M; Hernández-Muñoz, R | 1 |
| Berdanier, CD; Deaver, OE; McCusker, RH; Wander, RC | 1 |
| Ivanova, V; Tomova, N | 1 |
| Bloxham, DP; Handford, PA; Ner, SS; Wilton, DC | 1 |
| Kauppinen, RA; Nicholls, DG; Sihra, TS | 1 |
| Tomasiak, M | 1 |
| Eboli, ML; López-Alarcón, L | 1 |
| De Zwaan, A; Putzer, V | 1 |
| Choules, GL; Yarrison, G; Young, DW | 1 |
| Even, HL; Roon, RJ | 1 |
| Hatch, MD; Kagawa, T | 1 |
| Brosnan, JT; Williamson, DH | 1 |
| Cohen, GN; Truffa-Bachi, P; Veron, M | 1 |
| Fritz, PJ | 1 |
| Ahmad, F; Moat, AG | 1 |
| Isquith, AJ; Moat, AG | 1 |
| Katunuma, N; Matsuzawa, T | 1 |
| Gascoyne, T; Krebs, HA; Notton, BM | 1 |
| Din, GA; Lees, H; Suzuki, I | 1 |
| Hoberman, HD; Prosky, L | 1 |
| Katsuki, H; Murai, T; Nagai, J; Takeo, K | 1 |
| Bloch-Frankenthal, L; Melnik, Y | 1 |
| Meyer, E; Wurtz, B | 1 |
| Katz, J; Schmidt, K | 1 |
| Bressler, R; Ruderman, N; Shafrir, E | 1 |
| Meister, A; Tate, SS | 1 |
| Kojima, Y; Wacker, WE | 1 |
| Arnaud, M; Johnson, C; Nordmann, J; Nordmann, R | 1 |
| Nordmann, J; Nordmann, R | 1 |
| LaNoue, K; Nicklas, WJ; Williamson, JR | 1 |
| Davis, EJ; Lumeng, L | 2 |
| Sanwal, BD | 1 |
| Anderson, J; Blank, W; Niklas, W; Williamson, JR | 1 |
| Brosnan, JT; Krebs, HA; Williamson, DH | 1 |
| Chandler, JL; Gholson, RK; Scott, TA | 1 |
| LaNoue, KF; Williamson, JR | 1 |
| Scrutton, MC | 1 |
| Joy, KW; Pahlich, E | 1 |
| Heck, HA; Truffa-Bachi, P | 1 |
| Ellison, JS; Siegel, L | 1 |
| Ballard, FJ | 1 |
| Gutfreund, H | 1 |
| Ziegler, K | 1 |
| Ogur, M; Ulane, R | 1 |
| Cheng, SC | 1 |
| Chandler, JL; Gholson, RK | 2 |
| Häkkinen, HM; Kulonen, E | 1 |
| Garber, AJ; Hanson, RW | 1 |
| Blattmann, P; Rétey, J | 1 |
| Beattie, DS; Cederbaum, AI; Lieber, CS; Rubin, E | 1 |
| MacLeod, RA; Rogers, HJ; Thurman, P | 1 |
| Chandler, JL; Tritz, GJ | 1 |
| Iskushev, VS; Lifshits, RI; Slobodin, VB | 1 |
| Carlson, J; Gholson, RK; Griffith, G; Suzuki, N | 1 |
| Buchanan, JM | 1 |
| Cederbaum, AI; Lieber, CS; Rubin, E | 1 |
| LaNoue, KF; Safer, B; Smith, CM; Walajtys, E; Williamson, JR | 1 |
| Mahadevan, S; Sauer, F | 1 |
| Holmin, T; Siesjö, BK | 1 |
| Dionisi, O; Eboli, ML; Galeotti, T; Longhi, G; Terranova, T | 1 |
| Colman, RF; Siliski, JM | 1 |
| Loy, E; Müllhofer, G | 1 |
| Movsesian, SG | 1 |
| Brand, MD; Chappell, JB | 1 |
| Safer, H; Williamson, JR | 1 |
| Aprison, MH; Graham, LT | 1 |
| Felts, PW; Kreisberg, RA; Williamson, JR | 1 |
| Anson, RW; Ballard, FJ | 1 |
| Deodhar, AD; Mistry, SP | 1 |
| Bryan, JK | 1 |
| Yoshida, A | 1 |
| Hariharan, K; Rao, DR; Vijayalakshmi, KR | 1 |
| Ardouin, B; Baron, P; Doucet, C; Griffaton, G; Lowy, R | 1 |
| Santarius, KA; Stocking, CR | 1 |
| Cohen, GN; Le Bras, G; Stanier, RY | 1 |
| Chamalaun, RA; Tager, JM | 1 |
| Baron, P; Griffaton, G; Lowy, R | 2 |
| Katsuki, H; Murai, T; Nagai, J; Tokushige, M | 2 |
| Langer, BW; Smith, WJ; Theodorides, VJ | 1 |
| Mihara, K; Sato, R; Shimakata, T | 1 |
| Archer, K; Hartmann, HA; Schor, NA | 1 |
| Moat, AG; Thomulka, KW | 1 |
| Elmerich, C | 1 |
| Harris, RL; Veech, EH; Veech, RL; Veloso, D | 1 |
| Berdanier, CD; Shubeck, D | 1 |
| Benavides, J; García, ML; Giménez-Gallego, G; Valdivieso, F | 1 |
| Best, L; Malaisse, WJ; Malaisse-Lagae, F; Sener, A | 1 |
| Arenas-Diaz, G; Martínez-Murillo, R; Martínez-Rodriguez, R | 1 |
| Brdicka, R | 1 |
| Hassinen, IE; Hiltunen, JK; Kauppinen, RA | 1 |
| Heard, JT; Steiner, BM; Tritz, GJ | 1 |
| Ledig, M; M'Paria, JR; Mandel, P | 1 |
| Dawson, AG | 1 |
| Cooney, DA; Han, N; Kensler, TW | 1 |
| Koppenhafer, SL; Scholz, TD | 1 |
| Cui, K; Lu, AY; Ma, Q; Yang, CS | 1 |
| Catelloni, F; Fontaine, E; Keriel, C; Leverve, XM; Rigoulet, M; Sibille, B | 1 |
| Inagaki, Y; Kimura, T; Sawai, T; Yamaguchi, A | 1 |
| Bernard, N; Delcour, J; Holbrook, JJ; Johnsen, K | 1 |
| Böhm, G; Jaenicke, R; Tomschy, A | 1 |
| Alldread, RM; Atkinson, T; Clarke, AR; Halsall, DM; Nicholls, DJ; Scawen, MD; Sundaram, TK | 1 |
| Scaduto, RC | 1 |
| Li, Y; Man, WJ; O'Connor, CD; Wilton, DC | 1 |
| Gerber, NC; Sligar, SG | 1 |
| Deckers-Hebestreit, G; Hase, B; Strotmann, H; Werner-Grüne, S | 1 |
| Hara, A; Kaibe, H; Matsuura, K; Mitsui, Y; Nakanishi, M; Nonaka, T; Tanaka, N | 1 |
| Atlante, A; Gagliardi, S; Passarella, S | 1 |
| Koppenhafer, SL; Scholz, TD; Schutte, BC; tenEyck, CJ | 1 |
| Aoki, M; Ishimori, K; Morishima, I | 1 |
| Chun, YS; Kim, MS; Kwak, SJ; Park, JW; Park, SC; Park, YC | 1 |
| Barron, JT; Gu, L; Parrillo, JE | 1 |
| Brady, RL; Chapman, AD; Clarke, AR; Cortés, A; Dafforn, TR | 1 |
| Badii, R; Basran, J; Casarotto, MG; Roberts, GC; Sze, KH | 1 |
| Rao, NA; Savithri, HS; Talwar, R | 1 |
| Delley, M; Germond, JE; Hottinger, H; Kochhar, S; Lamzin, VS; Razeto, A | 1 |
| Aarhus, R; Graeff, R; Lee, HC; Levitt, D; Munshi, C; Walseth, TF | 1 |
| Jensen, RA; Luengo, JM; Miñambres, B; Olivera, ER | 1 |
| Rupert, BE; Scholz, TD; Schutte, BC; Segar, JL | 1 |
| Cleaves, HJ; Miller, SL | 1 |
| Edwards, JS; McCulloch, A; Palsson, BO; Ramakrishna, R | 1 |
| Gangloff, A; Garneau, A; Huang, YW; Lin, SX; Yang, F | 1 |
| Bragg, PD; Hou, C | 1 |
| Ballou, DP; Ludwig, ML; Matthews, RG; Trimmer, EE | 1 |
| Arai, T; Kamata, S; Sako, T; Takahashi, M | 1 |
| Moyer, RW; Shuman, S; Sriskanda, V | 1 |
| Arai, T; Azakami, D; Ikeda, M; Takahashi, M; Washizu, T | 1 |
| Shuman, S; Sriskanda, V | 1 |
| Fujioka, M; Gomi, T; Huang, Y; Komoto, J; Ogawa, H; Takata, Y; Takusagawa, F; Yamada, T | 1 |
| Miziorko, HM; Runquist, JA | 1 |
| Arnold, P; Baker, ME; Frey, FJ; Odermatt, A; Tam, S; Yan, L | 1 |
| Meijer, AJ | 1 |
| Addlagatta, A; Brandt, S; Duax, WL; Fuller, RR; Norris, W; Thomas, JL | 1 |
| KLITA, S; SZAFRANSKI, P | 1 |
| TAGER, JM | 1 |
| HERMIER, J; SIEGENTHALER, PA | 1 |
| ALLAN, PW; TOMISEK, AJ | 1 |
| COOPER, JR | 1 |
| BURCHALL, JJ; NIEDERMAN, RA; WOLIN, MJ | 1 |
| DURAND, R; GAUDEMER, Y; GAUTHERON, D; PIALOUX, N | 1 |
| ARKY, RA; COHEN, AK; FOSTER, AE; FREINKEL, N | 1 |
| CAMPBELL, JW; PRESCOTT, LM | 1 |
| Begum, L; Horiuchi, M; Iijima, M; Jalil, MA; Kobayashi, K; Li, MX; Moriyama, M; Robinson, BH; Saheki, T; Sinasac, DS; Tsui, LC | 1 |
| Hashimoto, T; Katoh, A | 1 |
| Fushinobu, S; Shoun, H; Su, F; Takaya, N | 1 |
| Shiro, Y; Shoun, H; Su, F; Takaya, N; Umemura, M | 1 |
| Kobayashi, K; Saheki, T | 1 |
| Amorini, AM; Cimatti, M; Delfini, R; Lazzarino, G; Marmarou, A; Signoretti, S; Tavazzi, B; Vagnozzi, R | 1 |
| Cook, PF; Harris, BG; Karsten, WE; Liu, D; Rao, GS | 1 |
| Ballou, DP; Brinker, DR; Casas, KR; Galloway, LJ; Scannell, SA; Trimmer, EE | 1 |
| Banerjee, S; Ray, M; Ray, S; SinhaRoy, S | 1 |
| Cabrera, ME; Saidel, GM; Stanley, WC; Yu, X; Zhou, L | 1 |
| McKenna, MC; Schousboe, A; Sonnewald, U; Waagepetersen, HS | 1 |
| Akita, M; Hashimoto, T; Katoh, A; Uenohara, K | 1 |
| Atlante, A; De Bari, L; Marra, E; Passarella, S; Seccia, TM | 1 |
| Bender, K; Brennan, L; Maechler, P; Newsholme, P | 1 |
| Contreras, L; Gomez-Puertas, P; Iijima, M; Kobayashi, K; Saheki, T; Satrústegui, J | 1 |
| Bzymek, KP; Colman, RF | 1 |
| Katunuma, N; Ohshima, T; Sakuraba, H; Tsuge, H; Yoneda, K | 1 |
| Arold, S; Assairi, L; Labesse, G; Pochet, S; Poncet-Montange, G | 1 |
| Easlon, E; Lin, SJ; Skinner, C; Tsang, F; Wang, C | 1 |
| Bairagya, HR; Mukhopadhyay, BP; Sekar, K | 1 |
| Contreras, L; Satrústegui, J | 1 |
| Lund, TM; Risa, O; Schousboe, A; Sonnewald, U; Waagepetersen, HS | 1 |
| Kawakami, R; Ohshima, T; Oyama, M; Sakuraba, H | 1 |
| Dutcher, SK; Kwan, AL; Lin, H | 1 |
| Doi, K; Mutaguchi, Y; Ohmori, T; Ohshima, T; Sakuraba, H; Yoneda, K | 1 |
| Ashida, H; Ishikawa, T; Kawakami, N; Li, Y; Ogola, HJ; Sawa, Y; Shibata, H | 1 |
| Amorini, AM; Barrios, L; Di Pietro, V; Marmarou, A; Marmarou, CR; Pascual, JM; Prieto, R; Tavazzi, B; Taya, K | 1 |
| Ashida, H; Ishida, M; Ishikawa, T; Li, Y; Sawa, Y; Shibata, H | 1 |
| Li, Y; Ogola, HJ; Sawa, Y | 1 |
| Abbrescia, DI; La Piana, G; Lofrumento, NE | 1 |
| Hertz, L; Li, B; Peng, L | 1 |
| Han, W; Min, W; Wang, D; Zhan, D | 1 |
| Aksentijević, D; Brookes, PS; Chouchani, ET; Costa, ASH; Dare, AJ; Davidson, SM; Duchen, MR; Eaton, S; Eyassu, F; Frezza, C; Gaude, E; Hartley, RC; Hu, CH; James, AM; Krieg, T; Logan, A; Murphy, MP; Nadtochiy, SM; Ord, ENJ; Pell, VR; Robb, EL; Robinson, AJ; Rogatti, S; Saeb-Parsy, K; Shattock, MJ; Shirley, R; Smith, AC; Sundier, SY; Work, LM | 1 |
| Banke, NH; Lewandowski, ED | 1 |
| Guan, KL; Lin, H; Ling, ZQ; Shi, Q; Xiong, Y; Yang, H; Yang, Y; Ye, D; Zhang, M; Zhao, S; Zhao, Y; Zhou, L | 1 |
| Bak, LK; Satrústegui, J | 1 |
| Beal, MF; Clark-Matott, J; Dai, Y; Ma, X; Safdar, A; Saleem, A; Shurubor, Y; Simon, DK; Tarnopolsky, M | 1 |
| Chen, J; Fernandez, J; Fernandez-Bueno, GA; Gusdon, AM; Mathews, CE; Wohlgemuth, S | 1 |
| Couté, Y; Ollagnier de Choudens, S; Reichmann, D | 1 |
| Amoedo, ND; De Grassi, A; Lacombe, D; Obre, E; Pierri, CL; Punzi, G; Rossignol, R | 1 |
| Hong, KM; Jang, H; Kang, JH; Kim, SY; Lee, C; Lee, JS; Lee, SH; Nam, B; Seong, TW; Son, J | 1 |
| Bush, LN; Davidson, SM; Freinkman, E; Gitego, N; Gui, DY; Hosios, AM; Luengo, A; Sullivan, LB; Thomas, CJ; Vander Heiden, MG | 1 |
| Hong, D; Hong, KM; Kang, JH; Kim, SY; Lee, JS; Lee, SH; Son, J; Song, J | 1 |
| Beyrath, J; Iannetti, EF; Koopman, WJH; Smeitink, JAM; Willems, PHGM | 1 |
| Agius, L; Alshawi, A | 1 |
| Altinok, O; Bowne, WB; Orynbayeva, Z; Poggio, JL; Shieh, AC; Snyder, NW; Stein, DE | 1 |
| Appanna, VD; Appanna, VP; Bley, AM; MacLean, A | 1 |
| Chen, C; Chen, GQ; Chen, X; Gu, H; Hao, X; He, X; Huang, D; Lai, X; Lin, SH; Liu, L; Loscalzo, J; Su, N; Xie, L; Yang, Y; Yu, Z; Zhang, X; Zhang, Y; Zhao, Y; Zheng, D; Zheng, J; Zou, Y | 1 |
| Gao, J; Zhang, YW; Zhou, Q | 1 |
| But, SY; Khmelenina, VN; Mustakhimov, II; Reshetnikov, AS; Rozova, ON | 1 |
| Guo, M; Jiang, X; Tang, W; Xu, H | 1 |
| Bharti, S; Bhujwalla, Z; Gabrielson, E; Tully, E; Woo, J | 1 |
| Kawai-Yamada, M; Konishi, M; Miyagi, A; Saito, M; Sakuraba, Y; Yanagisawa, S | 1 |
| Fowle-Grider, R; Patti, GJ; Schwaiger-Haber, M; Shriver, LP; Stancliffe, E; Wang, C; Wang, R; Wang, Y | 1 |
| Luo, J; Mu, X; Wang, Z; Yang, Q; Zhao, Y | 1 |
| Bernitzky, CCM; Greetham, GM; Higuchi, Y; Horch, M; Hunt, NT; Ishii, M; Karafoulidi-Retsou, C; Kulka-Peschke, CJ; Lauterbach, L; Lenz, O; Lorent, C; Matsuura, H; Preissler, J; Procacci, B; Rippers, Y; Schulz, AC; Schulz, C; Teutloff, C; Wahlefeld, S; Wiemann, C; Wrathall, SLD; Zebger, I | 1 |
| Chen, GB; Francisco, JC; Li, S; Singh, BK; Thimmukonda, NK; Yau, WW; Yen, PM; Zhou, J | 1 |
| Carlisle, SM; Davidsen, K; Engstrom, IA; Hart, ML; Hoellerbauer, P; Newsom, OJ; Quon, E; Sullivan, LB; Vigil, ABG | 1 |
| Ben-Sahra, I; Bost, F; Contenti, J; Guo, Y; Irondelle, M; Lago, C; Leva, G; Mazure, NM; Mazzu, A; Rouleau, M; Tiberi, L | 1 |
17 review(s) available for nad and aspartic acid
| Article | Year |
|---|---|
The Metabolic Significance of the Malate-Aspartate Cycle in Heart.
Topics: Animals; Anions; Aspartic Acid; Citric Acid Cycle; Cytosol; Glycolysis; Humans; Malates; Myocardium; NAD; Oxidation-Reduction | 1975 |
[Role of adenine mono- and dinucleotides in ammonia formation in brain tissue].
Topics: Adenine Nucleotides; Adenosine Monophosphate; Adenosine Triphosphate; Ammonia; AMP Deaminase; Animals; Aspartic Acid; Brain; Cyclic AMP; Deamination; Enzyme Activation; Glycolysis; Hexokinase; Inosine Nucleotides; Insulin; Isoenzymes; Liver; Mitochondria; Muscles; NAD; Rats | 1975 |
Metabolic adaptations of intertidal invertebrates to environmental hypoxia (a comparison of environmental anoxia to exercise anoxia).
Topics: Adaptation, Physiological; Adenosine Triphosphate; Alanine; Anaerobiosis; Animals; Annelida; Aspartic Acid; Crustacea; Glycogen; Mollusca; NAD; Nematoda; Oxygen; Pyruvate Oxidase; Pyruvates; Seawater | 1985 |
Structure, function, and possible origin of a bifunctional allosteric enzyme, Escherichia coli aspartokinase I-homoserine dehydrogenase I.
Topics: Adenosine Triphosphate; Alcohol Oxidoreductases; Allosteric Regulation; Amino Acids; Antigen-Antibody Reactions; Aspartic Acid; Binding Sites; Electrophoresis, Disc; Escherichia coli; Homoserine; Kinetics; Mercaptopurine; Molecular Weight; Multienzyme Complexes; NAD; NADP; Peptide Fragments; Phosphotransferases; Protein Binding; Protein Conformation; Ribonucleotides; Serine; Spectrophotometry; Sulfhydryl Compounds; Threonine | 1974 |
[Mechanisms of ammonia formation in the brain].
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Amino Acid Oxidoreductases; Amino Acids; Ammonia; Animals; Aspartic Acid; Brain; Brain Chemistry; Deamination; Dogs; Flavin-Adenine Dinucleotide; Fumarates; Glutamate Dehydrogenase; Glutaminase; Glutamine; Guanosine Triphosphate; Inosine Nucleotides; Mitochondria; Monoamine Oxidase; NAD; NADP; Nerve Tissue Proteins; Niacinamide; Oxidation-Reduction; Oxygen Consumption; Rats | 1973 |
Transients and relaxation kinetics of enzyme reactions.
Topics: Alcohol Oxidoreductases; Animals; Aspartic Acid; Catalase; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Computers; Endopeptidases; Enzymes; Escherichia coli; Flavoproteins; Glutamate Dehydrogenase; Glyceraldehyde-3-Phosphate Dehydrogenases; Hemoglobins; Homoserine; Horses; Hot Temperature; Kinetics; L-Lactate Dehydrogenase; Liver; Macromolecular Substances; Mathematics; Models, Biological; Muramidase; Myoglobin; NAD; Pancreas; Papain; Peroxidases; Phosphoric Monoester Hydrolases; Phosphotransferases; Protein Binding; Protein Conformation; Ribonucleases; Spectrophotometry; Temperature | 1971 |
Phosphoenolpyruvate carboxykinase. I. Its role in gluconeogenesis.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Carboxy-Lyases; Cytosol; Fasting; Feeding Behavior; Gluconeogenesis; Guanosine Triphosphate; Guinea Pigs; Humans; Ligases; Liver; Malates; Mitochondria, Liver; NAD; Oxaloacetates; Phosphoenolpyruvate; Pyruvates; Rabbits; Rats; Species Specificity | 1972 |
The amidotransferases.
Topics: Anthranilate Synthase; Asparagine; Aspartic Acid; Binding Sites; Carbamates; Cytosine Nucleotides; Fructosephosphates; Glutamine; Ligases; Liver; Macromolecular Substances; NAD; Organophosphorus Compounds; Protein Conformation; Pyrimidine Nucleotides; Ribose; RNA, Transfer; Transaminases; Xanthines | 1973 |
Mitochondrial-cytosolic interactions in cardiac tissue: role of the malate-aspartate cycle in the removal of glycolytic NADH from the cytosol.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Carbon Radioisotopes; Cytosol; Flavoproteins; Fluorometry; Glucose; Glutamates; Glycolysis; Heart; Hydrogen-Ion Concentration; In Vitro Techniques; Insulin; Ketone Oxidoreductases; Lactates; Malates; Mitochondria, Muscle; Myocardium; NAD; Oligomycins; Oxidation-Reduction; Oxygen Consumption; Perfusion; Phosphates; Rats; Tritium | 1973 |
Amino acids as regulators and components of nonproteinogenic pathways.
Topics: Amino Acids; Animals; Aspartic Acid; Cell Size; Glutamic Acid; Humans; Insulin; Islets of Langerhans; Metabolism; NAD; Oxidation-Reduction; Signal Transduction; Urea | 2003 |
Molecular biology of pyridine nucleotide and nicotine biosynthesis.
Topics: Animals; Aspartic Acid; Bacteria; Gene Expression; Kynurenine; Mammals; Models, Chemical; NAD; Nicotiana; Nicotine; Plants; Yeasts | 2004 |
[Molecular basis of citrin deficiency].
Topics: Aspartic Acid; Calcium; Calcium-Binding Proteins; Cholestasis, Intrahepatic; Chromosome Mapping; Citrullinemia; Gene Frequency; Homozygote; Humans; Infant, Newborn; Maleates; Membrane Transport Proteins; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Mutation; NAD; Organic Anion Transporters | 2004 |
Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools.
Topics: Animals; Aspartic Acid; Astrocytes; Biological Transport; Cytosol; Glycerophosphates; Malates; Mitochondria; Models, Biological; NAD; Neurons; Oxidation-Reduction | 2006 |
L-aspartate dehydrogenase: features and applications.
Topics: Amino Acid Oxidoreductases; Aspartic Acid; Biotechnology; NAD; Oxidation-Reduction | 2012 |
Fluctuations in Cytosolic Calcium Regulate the Neuronal Malate-Aspartate NADH Shuttle: Implications for Neuronal Energy Metabolism.
Topics: Animals; Aspartic Acid; Calcium Signaling; Cytosol; Energy Metabolism; Humans; Lactic Acid; Malates; Mitochondria; NAD; Neurons | 2015 |
AGC1/2, the mitochondrial aspartate-glutamate carriers.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Biological Transport, Active; Calcium-Binding Proteins; Cattle; Consensus Sequence; Glutamic Acid; Humans; Malates; Mice; Mitochondria; Mitochondrial Membrane Transport Proteins; Models, Molecular; NAD; Neoplasm Proteins; Organ Specificity; Organic Anion Transporters; Oxidation-Reduction; Protein Conformation; Sequence Alignment; Sequence Homology, Amino Acid | 2016 |
Metabolic manipulation by
Topics: Adenosine Triphosphate; Aspartic Acid; Homeostasis; Metabolic Networks and Pathways; Metals; NAD; NADP; Oxalates; Oxidation-Reduction; Oxidative Stress; Pseudomonas fluorescens; Reactive Oxygen Species; Stress, Physiological | 2020 |
233 other study(ies) available for nad and aspartic acid
| Article | Year |
|---|---|
Evidence for a critical glutamyl and an aspartyl residue in the function of pig heart diphosphopyridine nucleotide dependent isocitrate dehydrogenase.
Topics: Animals; Aspartic Acid; Binding Sites; Glutamates; Hydrogen-Ion Concentration; Isocitrate Dehydrogenase; Isocitrates; Kinetics; Myocardium; NAD; Protein Binding; Swine; Temperature | 1977 |
Some effects of glucose concentration and anoxia on glycolysis and metabolite concentrations in the perfused liver of fetal guinea pig.
Topics: Adenine Nucleotides; Animals; Aspartic Acid; Citric Acid Cycle; Female; Fructosediphosphates; Gestational Age; Glucose; Glutamates; Glycogen; Glycolysis; Guinea Pigs; Hypoxia; Liver; Male; NAD; NADP; Pentosephosphates; Perfusion; Pregnancy | 1978 |
Methodology for transport studies: graphical and computer curve fitting methods for glutamate and aspartate efflux kinetics.
Topics: Animals; Aspartic Acid; Biological Transport; Computers; Glutamates; Kinetics; Mathematics; Mitochondria; Mitochondria, Liver; Mitochondrial Swelling; NAD; NADP; Oxidation-Reduction; Oxygen Consumption; Rats | 1979 |
Isolation of a metabolite capable of differentially supporting the growth of nicotinamide adenine dinucleotide auxotrophs of Escherichia coli.
Topics: Aspartic Acid; Escherichia coli; Mutation; NAD; Niacinamide; Nicotinic Acids; Quinolinic Acids | 1975 |
Studies on the active transfer of reducing equivalents into mitochondria via the malate-aspartate shuttle.
Topics: Adenosine Triphosphate; Animals; Arsenic; Aspartic Acid; Biological Transport, Active; Carnitine; Dinitrophenols; Electron Transport; Glutamates; Hydroxybutyrates; Malates; Mitochondria, Liver; NAD; Oligomycins; Oxidation-Reduction; Palmitic Acids; Rats; Rotenone | 1975 |
Vitamin E deficiency in the rat. Cytoplasmic factors required for suppression of mitochondrial respiratory decline.
Topics: Animals; Aspartic Acid; Cell Fractionation; Cytoplasm; Dialysis; Hydroxybutyrates; Ketoglutaric Acids; Liver; Microsomes, Liver; Mitochondria, Liver; NAD; Oxaloacetates; Oxidation-Reduction; Oxygen Consumption; Rats; Subcellular Fractions; Vitamin E Deficiency | 1975 |
Molecular injury to mitochondria produced by ethanol and acetaldehyde.
Topics: Acetaldehyde; Adenosine Triphosphatases; Alcohol Oxidoreductases; Alcoholism; Animals; Aspartic Acid; Biological Transport; Calcium; Cytosol; Ethanol; Fatty Acids; Glycerolphosphate Dehydrogenase; Glycerophosphates; Humans; Liver; Malates; Male; Mitochondria, Liver; NAD; Oxidative Phosphorylation; Oxygen Consumption; Rats | 1975 |
Neurospora crassa conidial germination: role of endogenous amino acid pools.
Topics: Amino Acids; Aminobutyrates; Aspartic Acid; Chromatography; Cycloheximide; Flavin-Adenine Dinucleotide; Glutamates; NAD; Neurospora; Neurospora crassa; Spores, Fungal; Water | 1975 |
Occurrence of the malate-aspartate shuttle in various tumor types.
Topics: Aminooxyacetic Acid; Animals; Antimycin A; Aspartic Acid; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Krebs 2; Cell Line; Cyanides; Kinetics; Lactates; Leukemia L1210; Liver Neoplasms; Malates; Malonates; Mitochondria; NAD; Neoplasms, Experimental; Oxidation-Reduction; Pyruvates; Rotenone; Tricarboxylic Acids | 1976 |
Studies on the control of 4-aminobutyrate metabolism in 'synaptosomal' and free rat brain mitochondria.
Topics: 4-Aminobutyrate Transaminase; Aldehyde Oxidoreductases; Aminobutyrates; Animals; Aspartic Acid; Biological Transport; Brain; gamma-Aminobutyric Acid; Glutamates; Ketoglutaric Acids; Male; Mitochondria; NAD; Potassium; Rats; Rotenone; Synaptosomes | 1976 |
Detection of precursors of quinolinic acid in Escherichia coli.
Topics: Adenosine Triphosphate; Aspartic Acid; Cell-Free System; Chemical Phenomena; Chemistry; Dihydroxyacetone Phosphate; Escherichia coli; Flavin-Adenine Dinucleotide; Fructosephosphates; Ligases; NAD; Nicotinic Acids; Pyridines; Quinolinic Acids | 1976 |
Magnitude of malate-aspartate reduced nicotinamide adenine dinucleotide shuttle activity in intact respiring tumor cells.
Topics: Animals; Aspartic Acid; Carcinoma, Ehrlich Tumor; Citric Acid Cycle; Cytosol; Electron Transport; Glucose; Glycolysis; In Vitro Techniques; Lactates; Malates; Mice; Mitochondria; NAD; Neoplasms, Experimental; Oxygen Consumption; Pyruvates | 1977 |
[Effect of NAD recirculation on the mechanism of ATP stabilization in cytoplasm. Mathematical models].
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Aspartic Acid; Cytoplasm; Glycerophosphates; Glycolysis; Malates; Mathematics; Mitochondria; Models, Biological; NAD; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Phosphotransferases | 1977 |
The operation of the malate-aspartate shuttle in the reoxidation of glycolytic NADH in slices of fetal rat liver.
Topics: Adenosine Triphosphate; Aerobiosis; Aminooxyacetic Acid; Animals; Aspartic Acid; Cytosol; Fetus; Glycolysis; In Vitro Techniques; Lactates; Liver; Malates; NAD; Oxidation-Reduction; Rats | 1977 |
Evidence for the oxidation of glycolytic NADH by the malate-aspartate shuttle in Ehrlich ascites tumor cells.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Carcinoma, Ehrlich Tumor; Dihydroxyacetone Phosphate; Fructosediphosphates; Glucose; Glycolysis; Kinetics; Malates; Mice; NAD; Oxidation-Reduction | 1979 |
Incorporation of the hydrogen atoms of ethanol into amino acids in rat liver in vivo.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Chemical Phenomena; Chemistry; Deuterium; Ethanol; Female; Glutamates; Hydrogen; Liver; NAD; Proline; Rats | 1979 |
Quantitative evaluation of the activity of the malate-aspartate shuttle in Ehrlich ascites tumor cells.
Topics: Aminooxyacetic Acid; Animals; Arsenic; Aspartic Acid; Carcinoma, Ehrlich Tumor; Glucose; Glycolysis; L-Lactate Dehydrogenase; Malates; Mice; NAD; Oxamic Acid; Oxidation-Reduction; Oxygen Consumption | 1979 |
Reconstitution of malate-aspartate and alpha-glycerophosphate shuttle activity in rat skeletal muscle mitochondria.
Topics: Animals; Aspartic Acid; Electron Transport; Glycerophosphates; Malates; Male; Mitochondria, Muscle; NAD; Rats; Rotenone; Uncoupling Agents | 1979 |
Mitochondrial shuttle activities in hyperthyroid and normal rats and guinea pigs.
Topics: Adenosine Diphosphate; Animals; Aspartic Acid; Cyanides; Glycerophosphates; Guinea Pigs; Hyperthyroidism; Ketone Bodies; Kidney; Lactates; Malates; Mitochondria; Mitochondria, Liver; NAD; Oxygen Consumption; Pyruvates; Rats; Rotenone | 1979 |
CO2 fixation and its regulation in Anacystis nidulans (Synechococcus).
Topics: Adenosine Monophosphate; Amino Acids; Aspartic Acid; Carbon Dioxide; Carbon Radioisotopes; Carbonic Acid; Culture Media; Cyanobacteria; Glyceraldehyde-3-Phosphate Dehydrogenases; Light; NAD; NADP; Pentosephosphates; Phosphates; Phosphorus Radioisotopes; Species Specificity; Sugar Phosphates | 1975 |
On mechanisms in hyperammonemic coma--with particular reference to hepatic encephalopathy.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Ammonia; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Energy Metabolism; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Hepatic Encephalopathy; Humans; Ketoglutaric Acids; Mitochondria, Liver; NAD; Oxidation-Reduction; Time Factors | 1975 |
Studies on the de novo biosynthesis of NAD in Escherichia coli. The separation of the nadB gene product from the nadA gene product and its purification.
Topics: Aspartic Acid; Chromatography; Chromatography, Gel; Chromatography, Ion Exchange; Escherichia coli; Genetic Complementation Test; Genetics, Microbial; Hydroxyapatites; Macromolecular Substances; Multienzyme Complexes; Mutation; NAD; NADP; Organophosphorus Compounds; Protein Biosynthesis; Trioses | 1975 |
Oxidation of cytosolic NADH by the malate-aspartate shuttle in HuH13 human hepatoma cells.
Topics: Aspartic Acid; Carcinoma, Hepatocellular; Cytosol; Humans; Kinetics; Liver Neoplasms; Malates; NAD; Oxidation-Reduction; Tumor Cells, Cultured | 1992 |
Reducing-equivalent transfer to the mitochondria during gluconeogenesis and ureogenesis in hepatocytes from rats of different thyroid status.
Topics: Alanine; Animals; Aspartic Acid; Biological Transport; Cells, Cultured; Cytoplasm; Gluconeogenesis; Glutamates; Glutamic Acid; Hydrogen; Hyperthyroidism; Hypothyroidism; Male; Malonates; Mitochondria, Liver; NAD; Pyruvates; Pyruvic Acid; Rats; Rats, Wistar; Thyroid Gland; Urea | 1992 |
Interactions between mitochondria and cytoplasm in isolated hepatocytes.
Topics: Animals; Aspartic Acid; Biological Transport; Cytoplasm; Energy Metabolism; Enzymes; Glucose; Glycolysis; Liver; Malates; Male; Mitochondria, Liver; Multienzyme Complexes; NAD; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1992 |
Operation and energy dependence of the reducing-equivalent shuttles during lactate metabolism by isolated hepatocytes.
Topics: Ammonia; Animals; Aspartic Acid; Cytoplasm; Energy Metabolism; Gluconeogenesis; Lactates; Lactic Acid; Liver; Malates; Male; Mitochondria, Liver; NAD; Oxidation-Reduction; Palmitates; Rats; Rats, Inbred Strains; Valinomycin | 1992 |
Inhibition of malate-aspartate shuttle by the antitumor drug L-glutamic acid gamma-monohydroxamate in L1210 leukemia cells.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Glutamates; Hydroxamic Acids; Hydroxylamine; Hydroxylamines; Leukemia L1210; Malates; NAD | 1992 |
Characterization and nucleotide binding properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine replacement.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Dihydropteridine Reductase; Escherichia coli; Isoleucine; Kinetics; Liver; Mutagenesis, Site-Directed; NAD; NADP; Protein Conformation; Rats; Recombinant Proteins | 1992 |
Role of aspartic acid 38 in the cofactor specificity of Drosophila alcohol dehydrogenase.
Topics: Alcohol Dehydrogenase; Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Blotting, Western; Drosophila; Electrophoresis, Polyacrylamide Gel; Horses; Hot Temperature; Humans; Hydrogen-Ion Concentration; Kinetics; Liver; Models, Molecular; Molecular Sequence Data; Mutation; NAD; NADP; Protein Denaturation; Sequence Homology, Nucleic Acid | 1991 |
Role of aspartate-37 in determining cofactor specificity and binding in rat liver dihydropteridine reductase.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; Binding Sites; Blotting, Western; Dihydropteridine Reductase; Escherichia coli; Gene Expression; Kinetics; Liver; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Peptide Fragments; Plasmids; Rats; Recombinant Proteins; Transformation, Genetic | 1991 |
Flow-injection analysis of amino acids and their metabolites by immobilized vitamin B6-dependent enzymes. Sensitive determination of L-aspartate, L-glutamate, 2-oxoglutarate, and oxaloacetate.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Cattle; Enzymes, Immobilized; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Ketoglutaric Acids; Luminescent Measurements; Malate Dehydrogenase; NAD; Oxaloacetates; Pyridoxine | 1990 |
Site-directed mutagenesis of rat liver S-adenosylhomocysteinase. Effect of conversion of aspartic acid 244 to glutamic acid on coenzyme binding.
Topics: Adenosylhomocysteinase; Apoenzymes; Aspartic Acid; Base Sequence; Binding Sites; Cloning, Molecular; Escherichia coli; Glutamates; Glutamic Acid; Hydrolases; Kinetics; Liver; Molecular Sequence Data; Molecular Weight; Mutation; NAD; Oligonucleotide Probes; Recombinant Proteins | 1990 |
Active-site mutations of diphtheria toxin: effects of replacing glutamic acid-148 with aspartic acid, glutamine, or serine.
Topics: Adenosine Diphosphate Ribose; Affinity Labels; Aspartic Acid; Base Sequence; Binding Sites; Diphtheria Toxin; Glutamates; Glutamic Acid; Glutamine; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Peptide Elongation Factor 2; Peptide Elongation Factors; Serine; Substrate Specificity | 1990 |
An aspartate residue in yeast alcohol dehydrogenase I determines the specificity for coenzyme.
Topics: Alcohol Dehydrogenase; Amino Acid Sequence; Aspartic Acid; Base Sequence; Flavin-Adenine Dinucleotide; Kinetics; Models, Molecular; Molecular Sequence Data; NAD; Oligonucleotide Probes; Protein Conformation; Saccharomyces cerevisiae; Substrate Specificity | 1991 |
Identification of the principal catalytically important acidic residue of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Catalysis; Chromatography, Affinity; Cloning, Molecular; Coenzyme A; DNA Mutational Analysis; Glutamates; Glutaral; Hydroxymethylglutaryl CoA Reductases; Kinetics; Mevalonic Acid; Molecular Sequence Data; NAD; Oligonucleotides; Pseudomonas; Structure-Activity Relationship | 1990 |
Acute and chronic ethanol treatment in vivo increases malate-aspartate shuttle capacity in perfused rat liver.
Topics: Alanine; Aminooxyacetic Acid; Animals; Aspartic Acid; Biological Transport; Cytoplasm; Ethanol; Female; Glucose; Lactates; Liver; Malates; Mitochondria, Liver; NAD; Oxygen Consumption; Rats; Rats, Inbred Strains; Sorbitol; Time Factors | 1990 |
Cytosolic free calcium and NAD/NADH redox state in the cat cortex during in vivo activation of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cats; Cerebral Cortex; Cytosol; Fluorescent Dyes; In Vitro Techniques; Male; N-Methylaspartate; NAD; Oxidation-Reduction; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1989 |
Aspartyl peptide labeled by 2-(4-bromo-2,3-dioxobutylthio)adenosine 5'-diphosphate in the allosteric ADP site of pig heart NAD+-dependent isocitrate dehydrogenase.
Topics: Adenosine Diphosphate; Affinity Labels; Allosteric Site; Amino Acid Sequence; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Iodoacetates; Iodoacetic Acid; Isocitrate Dehydrogenase; Macromolecular Substances; Molecular Sequence Data; Myocardium; NAD; Peptide Fragments; Swine; Thionucleotides; Trypsin | 1989 |
Oxidation of cytosolic NADH by the malate-aspartate shuttle in MC29 hepatoma cells.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Chickens; Cytosol; Glutamine; Lactates; Lactic Acid; Liver Neoplasms, Experimental; Malates; Mitochondria; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid | 1989 |
Diphtheria toxin. Effect of substituting aspartic acid for glutamic acid 148 on ADP-ribosyltransferase activity.
Topics: Aspartic Acid; Base Sequence; Binding Sites; Cloning, Molecular; Corynebacterium diphtheriae; Diphtheria Toxin; Escherichia coli; Genes; Genes, Bacterial; Glutamates; Glutamic Acid; Mutation; NAD; Nucleotidyltransferases; Poly(ADP-ribose) Polymerases; Protein Binding | 1985 |
In vivo and in vitro adenosine stimulation of ethanol oxidation by hepatocytes, and the role of the malate-aspartate shuttle.
Topics: Adenosine; Animals; Aspartic Acid; Ethanol; Glutamates; Glutamic Acid; In Vitro Techniques; Liver; Malates; Male; Mitochondria, Liver; NAD; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1987 |
Diet effects on membrane phospholipid fatty acids and mitochondrial function in BHE rats.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Animals; Aspartic Acid; Coconut Oil; Corn Oil; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Fatty Acids; Glycerophosphates; Malates; Male; Membrane Lipids; Mitochondria, Liver; NAD; Oils; Phospholipids; Plant Oils; Rats; Rats, Mutant Strains | 1986 |
Significance of Cys-153 for the phosphatase activity of glyceraldehyde-3-phosphate dehydrogenase.
Topics: Acid Anhydride Hydrolases; Acylphosphatase; Animals; Aspartic Acid; Cystine; Edetic Acid; Enzyme Activation; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycine; Ligands; NAD; Phenanthrolines; Phosphoric Monoester Hydrolases; Swine | 1985 |
Site-directed mutagenesis of citrate synthase; the role of the active-site aspartate in the binding of acetyl-CoA but not oxaloacetate.
Topics: Acetyl Coenzyme A; Aspartic Acid; Bacteriophages; Base Sequence; Binding Sites; Citrate (si)-Synthase; Cloning, Molecular; DNA, Recombinant; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Immunoassay; Mutation; NAD; Oxaloacetates; Oxo-Acid-Lyases; Plasmids; Structure-Activity Relationship; Transformation, Bacterial | 1988 |
Aminooxyacetic acid inhibits the malate-aspartate shuttle in isolated nerve terminals and prevents the mitochondria from utilizing glycolytic substrates.
Topics: Acetates; Aminooxyacetic Acid; Animals; Aspartic Acid; Glycolysis; Guinea Pigs; In Vitro Techniques; Malates; Membrane Potentials; Mitochondria; NAD; Onium Compounds; Organophosphorus Compounds; Oxygen Consumption; Synaptosomes | 1987 |
Importance of the malate-aspartate shuttle for the reoxidation of glycolytically produced NADH and for cell aggregation in porcine blood platelets.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Blood Platelets; Cytosol; Glycolysis; Malate Dehydrogenase; Malates; Mitochondria; NAD; Oxidation-Reduction; Oxygen Consumption; Platelet Aggregation; Swine; Uncoupling Agents | 1987 |
Oxidation of reduced cytosolic nicotinamide adenine dinucleotide by the malate-aspartate shuttle in the K-562 human leukemia cell line.
Topics: Aminooxyacetic Acid; Arsenic; Arsenites; Aspartate Aminotransferases; Aspartic Acid; Cells, Cultured; Electron Transport; Humans; Lactates; Leukemia, Experimental; Malates; Mitochondria; NAD; Oxidation-Reduction; Pyruvates | 1986 |
Glutamate dehydrogenase from Mycoplasma laidlawii.
Topics: Acholeplasma laidlawii; Ammonium Sulfate; Aspartic Acid; Cell-Free System; Chemical Precipitation; Chromatography, Gel; Chromatography, Ion Exchange; Coenzymes; Electrophoresis, Disc; Glutamate Dehydrogenase; Hot Temperature; Hydrogen-Ion Concentration; Ketoglutaric Acids; Molecular Weight; Mycoplasma; NAD; NADP; Purine Nucleotides; Pyruvates; Staining and Labeling | 1972 |
Regulation of the nicotinamide adenine dinucleotide- and nicotinamide adenine dinucleotide phosphate-dependent glutamate dehydrogenases of Saccharomyces cerevisiae.
Topics: Amino Acids; Ammonia; Asparaginase; Aspartic Acid; Carbon; Cell-Free System; Culture Media; Glutamate Dehydrogenase; Glutamates; Methylamines; NAD; NADP; Nitrogen; Saccharomyces cerevisiae; Spectrophotometry | 1973 |
NAD malic enzyme in leaves with C-pathway photosynthesis and its role in C4 acid decarboxylation.
Topics: Acetyl Coenzyme A; Aspartate Aminotransferases; Aspartic Acid; Catalase; Centrifugation, Density Gradient; Chlorophyll; Fumarate Hydratase; Magnesium; Malate Dehydrogenase; Malates; Manganese; NAD; NADP; Photosynthesis; Plants; Species Specificity; Spectrophotometry, Ultraviolet; Sulfates | 1974 |
Mechanisms for the formation of alanine and aspartate on rat liver in vivo after administration of ammonium chloride.
Topics: Alanine; Alanine Transaminase; Ammonia; Ammonium Chloride; Animals; Arginine; Aspartic Acid; Centrifugation; Cycloserine; Ketoglutaric Acids; Liver; Male; NAD; NADP; Rats; Time Factors; Urea | 1974 |
Rabbit muscle lactate dehydrogenase 5; a regulatory enzyme.
Topics: Aconitum; Animals; Aspartic Acid; Citrates; Glutamates; In Vitro Techniques; Ketoglutaric Acids; Kinetics; L-Lactate Dehydrogenase; Lactates; Malates; Muscles; Myocardium; NAD; Oxaloacetates; Pyruvates; Rabbits; Succinates | 1965 |
Nicotinic acid biosynthesis in prototrophs and tryptophan auxotrophs of Saccharomyces cerevisiae.
Topics: Amidohydrolases; Aspartic Acid; Glutamates; In Vitro Techniques; Molecular Biology; Mutation; NAD; Nicotinic Acids; Oxidoreductases; Pyridines; Saccharomyces; Tryptophan | 1966 |
Biosynthesis of NAD and nicotinic acid by Clostridium butylicum.
Topics: Alanine; Aspartic Acid; Clostridium; Coenzyme A; Glycerol; In Vitro Techniques; NAD; Nicotinic Acids; Phosphates; Pyridines; Pyruvates; Succinates | 1966 |
Colorimetric assays for serum alanine transaminase and lactic dehydrogenase using diazonium zinc salt.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Aspartic Acid; Colorimetry; Glutamates; Glutarates; Indicators and Reagents; L-Lactate Dehydrogenase; Malate Dehydrogenase; Malates; NAD; Oxaloacetates; Pyridoxal Phosphate; Pyruvates | 1966 |
Generation of extramitochondrial reducing power in gluconeogenesis.
Topics: Alcohol Oxidoreductases; Animals; Aspartic Acid; Cytoplasm; Ethanol; Gluconeogenesis; In Vitro Techniques; Kidney; Lactates; Liver; Mice; NAD; Oxaloacetates; Pyruvates; Rats; Serine | 1967 |
Carbon dioxide fixation and phosphoenolpyruvate carboxylase in Ferrobacillus ferrooxidans.
Topics: Adenosine Triphosphate; Aspartic Acid; Bacteria; Carbon Dioxide; Carbon Isotopes; Carboxy-Lyases; Cell-Free System; Citrates; Coenzyme A; Glutamates; Hydrogen-Ion Concentration; Ketoglutaric Acids; Lyases; Magnesium; Malate Dehydrogenase; Malates; Manganese; NAD; Phosphates; Pyruvates; Spectrophotometry; Succinates; Threonine | 1967 |
Evidence of reduction of fumarate to succinate in perfused rat liver under conditions of reduced O2 tension.
Topics: Animals; Aspartic Acid; Citrates; Electron Transport; Fumarates; Glutamates; Glycerophosphates; In Vitro Techniques; Lactates; Liver; Malates; Male; Malonates; NAD; Oxygen; Pressure; Rats; Rotenone; Succinates; Tritium | 1967 |
Allosteric activation of DPN-linked malic enzyme from Escherichia coli by aspartate.
Topics: Aspartic Acid; Cellulose; Chemical Phenomena; Chemistry, Physical; Chromatography, Ion Exchange; Escherichia coli; Hot Temperature; Kinetics; Malate Dehydrogenase; Malates; Models, Biological; NAD; Spectrophotometry; Stimulation, Chemical | 1967 |
Further studies on the oxidation of extramitochondrial reduced nicotineamide-adenine dinucleotide in Landschuetz ascites tumor cells.
Topics: Aspartic Acid; Carbon Dioxide; Carbon Isotopes; Cell-Free System; Culture Techniques; Cytoplasm; Ketoglutaric Acids; Lactates; Manometry; NAD; Neoplasms, Experimental; Oxaloacetates; Oxidation-Reduction | 1968 |
[Research on the mechanism of oxidations in Pseudomonas fluorescens. IV. Role of dihydroorotate dehydrogenase].
Topics: Aspartic Acid; Cytochromes; NAD; Orotic Acid; Oxidoreductases; Peroxides; Pseudomonas | 1967 |
Metabolism of pyruvate and L-lactate by rat adipose tissue.
Topics: Acetoacetates; Adipose Tissue; Animals; Aspartic Acid; Butyrates; Carbon Dioxide; Carbon Isotopes; Cytoplasm; Deficiency Diseases; Diet; Dietary Fats; Epididymis; Epinephrine; Fasting; Fatty Acids; Glucose; Glutamates; Glycerol; Hydroxybutyrates; Keto Acids; Ketoglutaric Acids; Lactates; Lipids; Malates; Male; Mitochondria; NAD; Oxaloacetates; Propionates; Pyruvates; Rats; Stimulation, Chemical | 1969 |
Relation of fatty acid oxidation tgluconeogenesis: effect of pentenoic acid.
Topics: Acetoacetates; Alanine; Animals; Aspartic Acid; Ethanol; Fatty Acids; Gluconeogenesis; Hydroxybutyrates; Hypoglycemic Agents; In Vitro Techniques; Linoleic Acids; Liver; NAD; Oxidation-Reduction; Perfusion; Rats; Valerates | 1968 |
Regulation of the activity of L-aspartate beta-decarboxylase by a novel allosteric mechanism.
Topics: Alanine; Alcaligenes; Aspartic Acid; Binding Sites; Carbon Isotopes; Carboxy-Lyases; Chemical Phenomena; Chemistry; Chromatography, Gel; Ketoglutaric Acids; Kinetics; L-Lactate Dehydrogenase; Malate Dehydrogenase; Models, Biological; NAD; Pyruvates; Spectrum Analysis | 1969 |
An enzymatic method for the measurement of asparagine and a new assay of asparaginase activity.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Chemical Phenomena; Chemistry; Escherichia coli; Humans; Indicators and Reagents; Ketoglutaric Acids; Malate Dehydrogenase; Methods; NAD | 1969 |
[Research on the regulation of carbohydrate metabolism in vivo. I. Action of ethionine].
Topics: Acetoacetates; Adenine Nucleotides; Animals; Aspartic Acid; Carbohydrate Metabolism; Citrates; Citric Acid Cycle; Ethionine; Female; Glycogen; Glycolysis; Hydroxybutyrates; Lactates; Liver; Malates; Mitochondria, Liver; NAD; Pyruvates; Rats | 1969 |
[Regulation of carbohydrate metabolism in vivo. II. Action of ethanol].
Topics: Acetoacetates; Animals; Aspartic Acid; Carbohydrate Metabolism; Citrates; Ethanol; Female; Glutamates; Hydroxybutyrates; Keto Acids; Ketoglutaric Acids; Lactates; Liver; Liver Glycogen; Malates; Mitochondria, Liver; NAD; Pyruvates; Rats | 1969 |
Control of citric acid cycle activity in rat heart mitochondria.
Topics: Acetoacetates; Adenine Nucleotides; Animals; Aspartic Acid; Carbon Isotopes; Chromatography, Ion Exchange; Citrates; Citric Acid Cycle; Fumarates; Hydroxybutyrates; Ketoglutaric Acids; Kinetics; Malates; Mitochondria, Muscle; Myocardium; NAD; Oxygen Consumption; Pyruvates; Rats; Succinates | 1970 |
Demonstration in vitro of competition between added NADH and glutamate for oxidation by liver mitochondria.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Depression, Chemical; Glutamates; In Vitro Techniques; Malate Dehydrogenase; Mitochondria, Liver; NAD; Oxygen Consumption; Pyruvates; Rabbits; Stimulation, Chemical | 1970 |
Regulatory characteristics of the diphosphopyridine nucleotide-specific malic enzyme of Escherichia coli.
Topics: Adenosine Triphosphate; Aspartic Acid; Binding Sites; Calcium Phosphates; Chemical Precipitation; Chromatography, DEAE-Cellulose; Coenzyme A; Enzyme Activation; Escherichia coli; Ethanol; Hydrogen-Ion Concentration; Kinetics; Malate Dehydrogenase; Methods; NAD; Nucleotides; Quaternary Ammonium Compounds; Sulfates | 1970 |
Transfer of carbon and hydrogen across the mitochondrial membrane in the control of gluconeogenesis.
Topics: Animals; Aspartic Acid; Biological Transport; Carbon Isotopes; Gluconeogenesis; Glyceraldehyde-3-Phosphate Dehydrogenases; Lactates; Malates; Mitochondria, Liver; NAD; Pyruvates; Rats | 1970 |
Effects of ischaemia on metabolite concentrations in rat liver.
Topics: Acetoacetates; Adenine Nucleotides; Alanine; Ammonia; Animals; Aspartic Acid; Cycloserine; Freezing; Glutamate Dehydrogenase; Glutamates; Glutamine; Glutarates; Hydroxybutyrate Dehydrogenase; Hydroxybutyrates; Ischemia; Kinetics; Lactates; Liver; Liver Circulation; Malates; Male; Mitochondria, Liver; NAD; Pyruvates; Rats | 1970 |
Studies on the de novo biosynthesis of NAD in Escherichia coli. I. Labelling patterns from precursors.
Topics: Aspartic Acid; Carbon Isotopes; Escherichia coli; Glucose; Glycerol; NAD; Pyridines | 1970 |
Interrelationships between malate-aspartate shuttle and citric acid cycle in rat heart mitochondria.
Topics: Adenine Nucleotides; Animals; Aspartic Acid; Carnitine; Citric Acid Cycle; Coenzyme A; Fluorometry; Glutamates; In Vitro Techniques; Ketoglutaric Acids; Lactates; Malates; Mitochondria; Myocardium; NAD; Oligomycins; Oxaloacetates; Oxidation-Reduction; Oxygen Consumption; Polarography; Rats | 1971 |
Possible regulatory factors for pyruvate carboxylase with particular reference to enzyme from chicken liver.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Binding Sites; Calcium; Carbon Dioxide; Chemical Phenomena; Chemistry; Chickens; Coenzyme A; Gluconeogenesis; Glycerol; Hydrogen-Ion Concentration; Kinetics; Ligases; Liver; Magnesium; NAD; Oxaloacetates; Oxidation-Reduction; Potassium; Pyruvates; Quaternary Ammonium Compounds; Species Specificity; Sulfates; Temperature | 1971 |
Glutamate dehydrogenase from pea roots: purification and properties of the enzyme.
Topics: Alanine; Amination; Amino Acid Oxidoreductases; Aspartic Acid; Chemical Phenomena; Chemistry; Chromatography, Gel; Deamination; Dialysis; Dioxins; Edetic Acid; Electrophoresis; Enzyme Activation; Glutamate Dehydrogenase; Glutamates; Hydrogen-Ion Concentration; Ketoglutaric Acids; Kinetics; Molecular Weight; NAD; Plants; Quaternary Ammonium Compounds | 1971 |
Threonine-sensitive aspartokinase-homoserine dehydrogenase of Escherichia coli K 12. Reaction with 6-mercapto-9- -D-ribofuranosylpurine 5'-triphosphate.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Alcohol Oxidoreductases; Aminobutyrates; Aspartic Acid; Benzoates; Binding Sites; Catalysis; Chromatography, Gel; Circular Dichroism; Electrophoresis; Escherichia coli; Hydrogen-Ion Concentration; Hydroxybutyrates; Kinetics; Mathematics; Mercaptoethanol; Molecular Weight; NAD; Paper; Phosphotransferases; Spectrophotometry; Sulfhydryl Compounds; Sulfhydryl Reagents; Threonine; Tritium; Tromethamine; Ultraviolet Rays | 1971 |
Role of tyrosine in the substrate binding site of mitochondrial L-malate dehydrogenase from bovine heart muscle.
Topics: Acetates; Acylation; Animals; Aspartic Acid; Binding Sites; Carbon Isotopes; Carboxylic Acids; Catalysis; Cattle; Chemical Phenomena; Chemistry; Chlorides; Cysteine; Dicarboxylic Acids; Enzyme Activation; Fumarates; Glutamates; Hydrogen-Ion Concentration; Hydroxylamines; Imidazoles; Kinetics; Malate Dehydrogenase; Malates; Mercuribenzoates; Methane; Mitochondria, Muscle; Myocardium; NAD; Spectrophotometry; Sulfates; Sulfonic Acids; Tyrosine | 1971 |
Regulation of gluconeogenesis during exposure of young rats to hypoxic conditions.
Topics: Acetoacetates; Adenine Nucleotides; Adenosine Triphosphate; Animals; Aspartic Acid; Gluconeogenesis; Glucose; Glycogen; Hydroxybutyrates; Hypoxia; Lactates; Liver; Mitochondria, Liver; NAD; Pyruvates; Rats; Serine; Time Factors | 1971 |
[Current views on the therapy of hepatic coma].
Topics: Acute Kidney Injury; Adolescent; Amino Acids; Ammonia; Anti-Bacterial Agents; Arginine; Aspartic Acid; Coenzyme A; Diet Therapy; Exchange Transfusion, Whole Blood; Glutamates; Hepatic Encephalopathy; Humans; Malates; Male; NAD; Ornithine; Prednisone; Prognosis; Renal Dialysis; Thiamine Pyrophosphate; Thioctic Acid; Vasopressins | 1970 |
Genetic and physiological control of serine and glycine biosynthesis in Saccharomyces.
Topics: Acetates; Alanine; Ammonium Sulfate; Aspartic Acid; Carbon Isotopes; Cell-Free System; Chemical Precipitation; Chromatography, Paper; Culture Media; Fluorides; Genetics, Microbial; Glucose; Glutamates; Glycerolphosphate Dehydrogenase; Glycerophosphates; Glycine; Glycolysis; Glyoxylates; Isocitrates; Lyases; Mutation; NAD; Oxidative Phosphorylation; Saccharomyces; Serine; Spectrophotometry; Transferases | 1972 |
Pyruvate metabolism in the lobster nerve as affected by the partial pressure of carbon dioxide: observations on the synthesis of acetylcholine and on metabolic compartmentation.
Topics: Acetylcholine; Alanine; Animals; Aspartic Acid; Carbon Dioxide; Carbon Isotopes; Citrates; Glutamates; Isocitrate Dehydrogenase; Malates; NAD; Nephropidae; Peripheral Nerves; Pyruvates | 1972 |
Studies on the biosynthesis of NAD in Escherichia coli. 3. Precursors of quinolinic acid in vitro.
Topics: Acetates; Aspartic Acid; Carbon Isotopes; Drug Stability; Escherichia coli; Formates; Fructosephosphates; Genetics, Microbial; Glyceric Acids; Glycerol; Glycerophosphates; Hot Temperature; Hydrogen-Ion Concentration; Ligases; Mutation; NAD; Organophosphorus Compounds; Pyridines; Pyridoxal Phosphate; Pyridoxamine; Succinates; Tritium | 1972 |
Ethanol and the metabolic interrelations of carbohydrates and amino acids in brain preparations.
Topics: Adenosine Triphosphate; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Carbohydrate Metabolism; Carbon Isotopes; Ethanol; Glucose; Glucosephosphates; Glutamine; Hexokinase; In Vitro Techniques; Lactates; NAD; Pyruvates; Rats; Rats, Inbred Strains | 1972 |
Stereospecificity of the dihydroorotate-dehydrogenase reaction.
Topics: Asparagine; Aspartic Acid; Bacteria; Benzyl Compounds; Binding Sites; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chromatography, Thin Layer; Deuterium; Esters; Ethanol; Hydrogen; Kinetics; Magnetic Resonance Spectroscopy; NAD; Orotic Acid; Oxidation-Reduction; Oxidoreductases; Structure-Activity Relationship | 1972 |
Effect of chronic ethanol ingestion on mitochondrial permeability and the transport of reducing equivalents.
Topics: Acetone; Animals; Aspartate Aminotransferases; Aspartic Acid; Biological Transport; Diet; Ethanol; Fatty Acids, Nonesterified; Glycerolphosphate Dehydrogenase; Ketoglutaric Acids; Malate Dehydrogenase; Male; Mitochondria, Liver; Mitochondrial Swelling; NAD; Organophosphorus Compounds; Permeability; Quaternary Ammonium Compounds; Rats; Trioses | 1972 |
Comparative transport activity of intact cells, membrane vesicles, and mesosomes of Bacillus licheniformis.
Topics: Alanine; Amino Acids; Aspartic Acid; Bacillus; Biological Transport, Active; Carbon Isotopes; Cell Fractionation; Cell Membrane; Cell Membrane Permeability; Centrifugation, Density Gradient; Chromatography, Paper; Culture Media; Glutamates; Histidine; Inclusion Bodies; Light; Lysine; NAD; Sodium; Stereoisomerism; Succinates; Vitamin K | 1973 |
Recognition of a gene involved in the regulation of nicotinamide adenine dinucleotide biosynthesis.
Topics: Alleles; Aspartic Acid; Carbon Isotopes; Chromosome Mapping; Culture Media; Escherichia coli; Genes, Regulator; Genetic Complementation Test; Genotype; Mutation; NAD; Pyridines; Recombination, Genetic; Transduction, Genetic; Trioses | 1973 |
[The effect of L-aspartic acid in isoproterenol necrosis of cardiac muscle].
Topics: Alanine Transaminase; Amino Acids; Animals; Aspartate Aminotransferases; Aspartic Acid; Heart Diseases; Isoenzymes; Isoproterenol; L-Lactate Dehydrogenase; Liver; Malate Dehydrogenase; Mitochondria, Muscle; Myocardium; NAD; Necrosis; Oxidative Phosphorylation; Oxygen Consumption; Phosphates; Rabbits | 1972 |
Studies on the de novo biosynthesis of NAD in Escherichia coli. V. Properties of the quinolinic acid synthetase system.
Topics: Aspartic Acid; Carbon Isotopes; Chromatography, Gel; Drug Stability; Escherichia coli; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Molecular Weight; Multienzyme Complexes; Mutation; NAD; Organophosphorus Compounds; Pyridines; Trioses | 1973 |
The oxidation of acetate by liver mitochondria.
Topics: Acetates; Acetoacetates; Adenine Nucleotides; Animals; Arsenic; Aspartic Acid; Carbon Isotopes; Glutamates; Hydroxybutyrates; Ketoglutaric Acids; Malates; Mitochondria, Liver; NAD; Oxygen Consumption; Rats; Succinates | 1973 |
Effect of acetaldehyde on activity of shuttles for the transport of reducing equivalents into the mitochondria.
Topics: Acetaldehyde; Alcohol Oxidoreductases; Animals; Aspartic Acid; Biological Transport; Ethanol; Fatty Acids; Glycerophosphates; Malates; Mitochondria, Liver; NAD; Oxidation-Reduction; Rats | 1973 |
Metabolite synthesis by rat liver cells and rat liver mitochondria.
Topics: Acetates; Animals; Aspartic Acid; Carbon Radioisotopes; Cell Membrane; Citrates; Cytological Techniques; Cytoplasm; Evaluation Studies as Topic; Fatty Acids; Glutamates; Hydroxybutyrates; Ketoglutaric Acids; Liver; Malates; Microbial Collagenase; Mitochondria, Liver; NAD; Oxidation-Reduction; Rats | 1973 |
De novo biosynthesis of nicotinamide adenine dinucleotide in Escherichia coli: excretion of quinolinic acid by mutants lacking quinolinate phosphoribosyl transferase.
Topics: Amino Acids; Aspartic Acid; Culture Media; Dicarboxylic Acids; Enzyme Repression; Escherichia coli; Feedback; Glycerol; Hydrogen-Ion Concentration; Mutation; NAD; Nicotinic Acids; Pentosyltransferases; Pyridines; Ribose | 1972 |
Effects of pyrazole, 4-bromopyrazole and 4-methylpyrazole on mitochondrial function.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Ascorbic Acid; Aspartic Acid; Citrates; Electron Transport; Electron Transport Complex IV; Fatty Acids; Glutamates; Glycerophosphates; Ketoglutaric Acids; Malates; Mitochondria, Liver; Mitochondrial Swelling; NAD; Oxidative Phosphorylation; Oxygen Consumption; Phosphates; Phosphorus Radioisotopes; Pyrazoles; Rats; Succinate Dehydrogenase; Succinates | 1974 |
The effect of porta-caval anastomosis upon the energy state and upon acid-base parameters of the rat brain.
Topics: Acid-Base Equilibrium; Ammonia; Animals; Aspartic Acid; Brain; Brain Stem; Carbon Dioxide; Cerebellum; Frontal Lobe; Glucose; Glucosephosphates; Glutamates; Hydrogen-Ion Concentration; Ketoglutaric Acids; L-Lactate Dehydrogenase; Malate Dehydrogenase; Male; Microelectrodes; NAD; Organ Specificity; Oxidation-Reduction; Oxygen; Phosphates; Portacaval Shunt, Surgical; Rats; Time Factors | 1974 |
Oxidation of reduced nicotinamide-adenine dinucleotide by the malate-aspartate shuttle in Ehrlich ascites tumour cells.
Topics: Acetates; Animals; Antimycin A; Aspartate Aminotransferases; Aspartic Acid; Benzimidazoles; Carcinoma, Ehrlich Tumor; Electron Transport; Energy Transfer; Hydroxylamines; Kinetics; Lactates; Malates; Mice; Mitochondria; NAD; Nitrogen; Oligomycins; Oxidation-Reduction; Rotenone; Time Factors | 1974 |
Recommended methods for the determination of four enzymes in blood.
Topics: Alanine; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Aspartic Acid; Buffers; Catalysis; Edetic Acid; Ethanolamines; Humans; Hydrochloric Acid; Indicators and Reagents; Ketoglutaric Acids; L-Lactate Dehydrogenase; Magnesium Oxide; Malate Dehydrogenase; Methods; NAD; Phosphoric Acids; Pyridoxal; Pyruvates; Scandinavian and Nordic Countries; Swine; Temperature; Tromethamine | 1974 |
Effects of clofibrate on mitochondrial function.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Ascorbic Acid; Aspartic Acid; Calcium; Clofibrate; Energy Metabolism; Ethanol; Glycerophosphates; In Vitro Techniques; Ketoglutaric Acids; Malates; Membranes; Mitochondria, Liver; NAD; Oxidative Phosphorylation; Oxygen Consumption; Permeability; Phosphorus Radioisotopes; Rats; Succinates | 1974 |
The kinetics of NAD-linked isocitrate dehydrogenase from calf heart.
Topics: Adenosine Diphosphate; Animals; Aspartic Acid; Binding Sites; Calorimetry; Cattle; Glutamates; Hydrogen-Ion Concentration; Isocitrate Dehydrogenase; Isocitrates; Kinetics; Manganese; Mathematics; Myocardium; NAD; Protein Binding; Spectrophotometry, Ultraviolet; Temperature; Thermodynamics | 1974 |
A possible role of the glycerol phosphate cycle in cyclic AMP-stimulated gluconeogenesis from lactate in perfused rat livers.
Topics: Animals; Aspartic Acid; Bucladesine; Carbon Radioisotopes; Cytosol; Fasting; Gluconeogenesis; Glucose; Glutamates; Glycerolphosphate Dehydrogenase; Glycerophosphates; Glycogen; In Vitro Techniques; Ketone Bodies; Lactates; Liver; Malates; Male; NAD; Perfusion; Pyruvates; Rats; Stimulation, Chemical; Thyroxine; Time Factors; Triiodothyronine; Tritium | 1974 |
[Participation of nicotinamide-hypoxanthine-dinucleotide (deamino-NAD) in nitrogen and energy metabolism].
Topics: Adenosine Monophosphate; Alcohol Oxidoreductases; Ammonia; Animals; Antimycin A; Aspartic Acid; Brain; Brain Chemistry; Cell Nucleus; Deamination; Energy Metabolism; Glutamates; Glycolysis; Ketoglutaric Acids; Microsomes; Mitochondria; Mitochondria, Liver; NAD; Niacinamide; Nitrogen; Nitrogen Isotopes; Nucleotides; Oxidative Phosphorylation; Rabbits; Rats; Rotenone; Subcellular Fractions; Succinates; Time Factors; Transaminases; Yeasts | 1973 |
Glutamate and aspartate transport in rat brain mitochondria.
Topics: Animals; Aspartic Acid; Biological Transport; Brain; Glutamates; Glutaminase; Glutamine; In Vitro Techniques; Kidney; Malates; Mitochondria; Mitochondria, Liver; NAD; Osmosis; Potassium; Quaternary Ammonium Compounds; Rats; Swine; Valinomycin | 1974 |
Functional significance of the malate-aspartate shuttle for the oxidation of cytoplasmic reducing equivalents in rat heart.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Biological Transport, Active; Cytoplasm; Electron Transport; Flavoproteins; Hydrogen-Ion Concentration; Lactates; Malates; Male; Mitochondria, Muscle; Models, Biological; Myocardium; NAD; Organophosphorus Compounds; Pyruvates; Rats | 1972 |
Fluorometric determination of aspartate, glutamate, and gamma-aminobutyrate in nerve tissue using enzymic methods.
Topics: Aminobutyrates; Animals; Aspartic Acid; Cats; Fluorometry; Glutamates; In Vitro Techniques; Microchemistry; NAD; NADP; Nerve Tissue; Spinal Cord | 1966 |
Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver.
Topics: Animals; Aspartic Acid; Citrates; Citric Acid Cycle; Coenzyme A; Gluconeogenesis; Glutamates; In Vitro Techniques; Ketoglutaric Acids; Ketone Bodies; Liver; Malates; NAD; NADP; Oleic Acids; Oxaloacetates; Perfusion; Rats | 1966 |
The metabolic fate of the products of citrate cleavage. Adenosine triphosphate-citrate lyase and nicotinamide-adenine dinucleotide phosphate-linked malate dehydrogenase in foetal and adult liver from ruminants and non-ruminants.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Carbon Dioxide; Carbon Isotopes; Cattle; Citrates; Fatty Acids; Female; Fetus; Glucose; Glutamates; In Vitro Techniques; Lipids; Liver; Lyases; Malate Dehydrogenase; Male; NAD; NADP; Pregnancy; Rats | 1968 |
Control of gluconeogenesis in biotin-deficient rat liver.
Topics: Alanine; Animals; Aspartic Acid; Avitaminosis; Bicarbonates; Biotin; Blood Glucose; Carbon Isotopes; Fatty Acids, Nonesterified; Gluconeogenesis; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycerol; Lactates; Ligases; Liver; Liver Glycogen; Male; NAD; NADP; Pyruvates; Rats; Succinates; Time Factors | 1969 |
Studies on the catalytic and regulatory properties of homoserine dehydrogenase of Zea mays roots.
Topics: Alcohol Oxidoreductases; Aminobutyrates; Aspartic Acid; Binding Sites; Cysteine; Hydroxybutyrates; Kinetics; NAD; NADP; Plants; Serine; Zea mays | 1969 |
Human glucose 6-phosphate dehydrogenase: purification and characterization of Negro type variant (A+) and comparison with normal enzyme (B+).
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Black People; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis; Erythrocytes; Glucosephosphate Dehydrogenase; Guanidines; Humans; Hydrogen-Ion Concentration; Immune Sera; Immunodiffusion; Isoenzymes; Kinetics; Magnesium; Male; Molecular Weight; NAD; NADP; Rabbits; Ultracentrifugation | 1967 |
A study of the metabolism of L-alpha gamma-diaminobutyric acid in a Xanthomonas species.
Topics: Aminobutyrates; Aspartate-Semialdehyde Dehydrogenase; Aspartic Acid; Hydrogen-Ion Concentration; NAD; Oxaloacetates; Transaminases; Xanthomonas | 1969 |
[Determination of substrate concentrations and cofactors in rat liver].
Topics: Acetoacetates; Alanine; Animals; Aspartic Acid; Citrates; Citric Acid Cycle; Glutamates; Glycerophosphates; Hydroxybutyrates; Ketoglutaric Acids; Lactates; Liver; Malates; NAD; NADP; Oxaloacetates; Pyruvates; Rats; Trioses | 1969 |
Intracellular localization of enzymes in leaves and chloroplast membrane permeability to compounds involved in amino acid syntheses.
Topics: Alanine; Alcohol Oxidoreductases; Amino Acid Oxidoreductases; Amino Acids; Aspartate Aminotransferases; Aspartic Acid; Carbon Dioxide; Chloroplasts; Glutamate Dehydrogenase; Glutamates; Glutathione Reductase; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycine; Isocitrate Dehydrogenase; Malate Dehydrogenase; NAD; NADP; Nicotiana; Oxidoreductases; Plants; Plants, Edible; Plants, Toxic; Pyruvate Kinase; Serine | 1969 |
Regulation of the biosynthesis of amino acids of the aspartate family in Coliform bacteria and Pseudomonads.
Topics: Aeromonas; Alcohol Oxidoreductases; Aspartic Acid; Enterobacteriaceae; NAD; NADP; Phosphotransferases; Pseudomonas | 1969 |
Nitrogen metabolism in the perfused rat liver.
Topics: Alanine; Ammonia; Ammonium Chloride; Animals; Aspartic Acid; Glutamate Dehydrogenase; Glutamates; Glutamine; Hydroxybutyrate Dehydrogenase; Liver; NAD; NADP; Nitrogen; Perfusion; Rats; Stimulation, Chemical; Urea | 1970 |
[Metabolic disorders induced by an acute dose of ethanol in the liver of the adrenalectomized rat].
Topics: Adrenal Glands; Adrenalectomy; Animals; Aspartic Acid; Ethanol; Glutamates; Glycerophosphates; Hydrocortisone; Hydroxybutyrates; Injections, Intramuscular; Injections, Intraperitoneal; Liver; Malates; Male; NAD; NADP; Phosphates; Rats; Time Factors | 1970 |
[Effects of an intraperitoneal injection of fructose on the hepatic metabolism of the rat].
Topics: Alanine; Animals; Aspartic Acid; Citrates; Citric Acid Cycle; Fasting; Fructose; Glutamates; Glycolysis; Injections, Intraperitoneal; Ketoglutaric Acids; Lipids; Liver; Malates; Male; NAD; NADP; Oxaloacetates; Rats; Stimulation, Chemical; Time Factors; Transaminases | 1970 |
Physiological functions of NAD- and NADP-linked malic enzymes in Escherichia coli.
Topics: Acetates; Aspartic Acid; Binding Sites; Carbon Isotopes; Cell-Free System; Centrifugation; Coenzyme A; Culture Media; Depression, Chemical; Enzyme Induction; Enzyme Repression; Escherichia coli; Fatty Acids; Glucose; Glutamates; Glycerol; Glycolysis; Lactates; Malate Dehydrogenase; Malates; Models, Biological; Models, Chemical; NAD; NADP; Pyruvates; Spectrophotometry; Stimulation, Chemical; Succinates; Vibration | 1971 |
Conversion of the alpha-hydroxy and alpha-keto analogues of methionine to methionine by cell-free extracts of adult female Ascaris suum.
Topics: Ascaris; Asparagine; Aspartic Acid; Butyrates; Cell-Free System; Female; Glutamates; Glutamine; Methionine; NAD; NADP; Oxidation-Reduction; Proteins | 1971 |
Lack of correlation between cyanide-binding spectrum and fatty acid desaturase activity in liver microsomes.
Topics: Adipose Tissue; Animals; Aspartic Acid; Carbon Isotopes; Coenzyme A; Cyanides; Cytochromes; Dietary Carbohydrates; Epididymis; Fasting; Fatty Acids; Kinetics; Male; Microsomes; Microsomes, Liver; NAD; NADP; Oxidoreductases; Oxygen; Potassium; Protein Binding; Rats; Spectrophotometry; Stearic Acids; Threonine; Time Factors | 1971 |
Enzyme activities in the anterior horn of spinal cord after , -iminodipropionitrile.
Topics: Age Factors; Animals; Aspartate Aminotransferases; Aspartic Acid; Axons; Gluconates; Glucosephosphate Dehydrogenase; Glucosephosphates; Isocitrate Dehydrogenase; Isocitrates; Male; Motor Neurons; Movement Disorders; NAD; NADP; Neurons, Afferent; Nitriles; Phosphogluconate Dehydrogenase; Rats; Spinal Cord | 1971 |
Inorganic nitrogen assimilation in yeasts: alteration in enzyme activities associated with changes in cultural conditions and growth phase.
Topics: Alanine; Alanine Transaminase; Amino Acid Oxidoreductases; Amino Acids; Ammonium Sulfate; Aspartate Aminotransferases; Aspartic Acid; Cell-Free System; Culture Media; Electrophoresis, Disc; Genetics, Microbial; Glucose; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Hydro-Lyases; Hydrogen-Ion Concentration; Lyases; Mutation; NAD; NADP; Nitrogen; Saccharomyces; Saccharomyces cerevisiae; Spectrophotometry; Threonine; Transaminases | 1972 |
[Glutamate cycle, first step of nitrogen metabolism in Bacillus megaterium].
Topics: Alanine; Allosteric Regulation; Amino Acid Oxidoreductases; Ammonia; Aspartic Acid; Bacillus megaterium; Enzyme Repression; Glucose; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Ketoglutaric Acids; Lyases; Mutation; NAD; NADP; Nitrogen; Oxaloacetates; Oxidoreductases; Pyruvates; Transaminases | 1972 |
Studies on regulatory functions of malic enzymes. I. Metabolic functions of NAD- and NADP-linked malic enzymes in Escherichia coli.
Topics: Acetates; Aspartic Acid; Carbon Isotopes; Cell-Free System; Coenzyme A; Escherichia coli; Fatty Acids; Glucose; Glutamates; Glycerol; Lactates; Malate Dehydrogenase; Malates; NAD; NADP; Pyruvates; Succinates | 1972 |
Freeze-blowing: a new technique for the study of brain in vivo.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Aspartic Acid; Brain; Brain Chemistry; Equipment and Supplies; Freezing; Glucose; Iron; Lactates; Malates; Male; Methods; Microwaves; NAD; NADP; Oxidation-Reduction; Phosphates; Phosphocreatine; Pressure; Pyruvates; Rats | 1973 |
Effects of thyroid hormone on mitochondrial activity in lipemic BHE rats.
Topics: Animals; Aspartic Acid; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Glycerophosphates; Malates; Male; Mitochondria, Liver; NAD; Oxygen Consumption; Rats; Rats, Inbred Strains; Thyroxine | 1981 |
Coupling between reduced nicotinamide adenine dinucleotide oxidation and metabolite transport in renal brush border membrane vesicles.
Topics: Animals; Aspartic Acid; Biological Transport, Active; Cell Membrane; In Vitro Techniques; Kidney Tubules, Proximal; Microvilli; NAD; Oxidation-Reduction; Potassium; Protons; Rats; Sodium | 1980 |
The stimulus-secretion coupling of amino acid-induced insulin release: metabolism of L-asparagine in pancreatic islets.
Topics: Acetyl Coenzyme A; Animals; Asparaginase; Asparagine; Aspartic Acid; Cytosol; Fatty Acids; Islets of Langerhans; Kinetics; Mitochondria; NAD; NADP; Oxaloacetates; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rats | 1984 |
Action of L-aspartic, methyl aspartic and acetyl aspartic acids on GABA transaminase histochemical activity in nervous tissue.
Topics: 4-Aminobutyrate Transaminase; Animals; Aspartic Acid; Brain; N-Methylaspartate; NAD; NADP; Rats; Rats, Inbred Strains | 1984 |
Present status in searching for biochemical markers among laboratory inbred rat strains (Rattus norvegicus).
Topics: Acid Phosphatase; Adenylyl Cyclases; Alanine; Alanine Transaminase; Alleles; Animals; Aspartate Aminotransferases; Aspartic Acid; Dihydrolipoamide Dehydrogenase; Erythrocytes; Esterases; Glucose-6-Phosphate Isomerase; Glucosephosphates; NAD; Peptide Hydrolases; Phosphoglucomutase; Phosphogluconate Dehydrogenase; Proteins; Rats; Rats, Inbred Strains; Uridine Kinase; Uridine Monophosphate | 1980 |
Mitochondrial membrane potential, transmembrane difference in the NAD+ redox potential and the equilibrium of the glutamate-aspartate translocase in the isolated perfused rat heart.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport, Active; Glutamates; Intracellular Membranes; Male; Membrane Potentials; Mitochondria, Heart; Myocardium; NAD; Oxidation-Reduction; Rats | 1983 |
Modification of aspartate before its condensation with dihydroxyacetone phosphate during quinolinic acid formation in Escherichia coli.
Topics: Aspartic Acid; Cell-Free System; Dihydroxyacetone Phosphate; Escherichia coli; Fructosediphosphates; Histidine; Mutation; NAD; Proline; Pyridines; Quinolinic Acids; Trioses | 1980 |
Free amino acids in the brain of ethanol treated rats.
Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport; Brain Chemistry; Ethanol; gamma-Aminobutyric Acid; Glutamates; Glutamine; Male; NAD; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1982 |
Rapid oxidation of NADPH via the reconstituted malate-aspartate shuttle in systems containing mitochondrial and soluble fractions of rat liver: implications for ethanol metabolism.
Topics: Animals; Aspartic Acid; Ethanol; Female; In Vitro Techniques; Liver; Malates; Mitochondria, Liver; NAD; Oxidation-Reduction; Oxygen Consumption; Proteins; Rats; Rats, Inbred Strains | 1982 |
A straightforward method for the simultaneous preparation of radiolabeled L-dihydroörotic and N-carbamyl-L-aspartic acids.
Topics: Aspartic Acid; Carbon Radioisotopes; Chromatography, Ion Exchange; Electrophoresis; Isotope Labeling; NAD; Orotic Acid | 1981 |
Reducing equivalent shuttles in developing porcine myocardium: enhanced capacity in the newborn heart.
Topics: Adenosine Triphosphate; Aerobiosis; Animals; Animals, Newborn; Aspartic Acid; Biological Transport; Glycerophosphates; Heart; Malates; Mitochondria, Heart; Myocardial Contraction; NAD; Oxidation-Reduction; Swine | 1995 |
Roles of histidine-194, aspartate-163, and a glycine-rich sequence of NAD(P)H:quinone oxidoreductase in the interaction with nicotinamide coenzymes.
Topics: Animals; Aspartic Acid; Base Sequence; Binding Sites; Consensus Sequence; DNA Primers; Histidine; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; NAD(P)H Dehydrogenase (Quinone); NADP; Oxidation-Reduction; Rats; Structure-Activity Relationship; Vitamin K | 1995 |
Octanoate affects 2,4-dinitrophenol uncoupling in intact isolated rat hepatocytes.
Topics: 2,4-Dinitrophenol; Adenine Nucleotides; Animals; Aspartic Acid; Caprylates; Cell Separation; Dihydroxyacetone; Dinitrophenols; Electron Transport; Fatty Acids; Glucose; Lactates; Lactic Acid; Liver; Malates; Male; NAD; Oxidation-Reduction; Oxygen Consumption; Pyruvates; Pyruvic Acid; Rats; Rats, Wistar | 1995 |
Substrate-induced acceleration of N-ethylmaleimide reaction with the Cys-65 mutant of the transposon Tn10-encoded metal-tetracycline/H+ antiporter depends on the interaction of Asp-66 with the substrate.
Topics: Amino Acid Sequence; Antiporters; Aspartic Acid; Bacterial Proteins; Base Sequence; Cell Membrane; Cysteine; DNA Transposable Elements; Escherichia coli; Ethylmaleimide; Magnesium; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Protein Conformation; Tetracycline | 1995 |
D175 discriminates between NADH and NADPH in the coenzyme binding site of Lactobacillus delbrueckii subsp. bulgaricus D-lactate dehydrogenase.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Bacteria; Base Sequence; Binding Sites; Consensus Sequence; Kinetics; L-Lactate Dehydrogenase; Lactobacillus; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; NADP; Oligodeoxyribonucleotides; Point Mutation; Recombinant Proteins; Sequence Homology, Amino Acid; Substrate Specificity | 1995 |
The effect of ion pairs on the thermal stability of D-glyceraldehyde 3-phosphate dehydrogenase from the hyperthermophilic bacterium Thermotoga maritima.
Topics: Amino Acid Sequence; Arginine; Aspartic Acid; Base Sequence; Enzyme Stability; Glutamic Acid; Glyceraldehyde-3-Phosphate Dehydrogenases; Gram-Negative Anaerobic Bacteria; Hot Temperature; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Sequence Alignment | 1994 |
Catalytic-rate improvement of a thermostable malate dehydrogenase by a subtle alteration in cofactor binding.
Topics: Aspartic Acid; Base Sequence; Catalysis; Enzyme Stability; Glutamic Acid; Hot Temperature; Malate Dehydrogenase; Models, Chemical; Molecular Sequence Data; Mutagenesis; Mutation; NAD; Oxaloacetates; Oxidation-Reduction; Protein Conformation; Recombinant Proteins; Solvents; Structure-Activity Relationship; Thermus; Viscosity | 1995 |
Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria.
Topics: Animals; Aspartic Acid; Calcium; Dinitrophenols; Enzyme Activation; Glutamates; Glutamic Acid; Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Malates; Membrane Potentials; Mitochondria, Heart; Models, Biological; NAD; Pyruvates; Pyruvic Acid; Rats | 1994 |
The effect of replacing the conserved active-site residues His-264, Asp-312 and Arg-314 on the binding and catalytic properties of Escherichia coli citrate synthase.
Topics: Anilino Naphthalenesulfonates; Arginine; Aspartic Acid; Base Sequence; Binding Sites; Catalysis; Citrate (si)-Synthase; Dithionitrobenzoic Acid; Escherichia coli; Histidine; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Protein Conformation; Structure-Activity Relationship | 1994 |
A role for Asp-251 in cytochrome P-450cam oxygen activation.
Topics: Aspartic Acid; Camphor 5-Monooxygenase; Catalysis; Cytochrome P-450 Enzyme System; Hydrogen-Ion Concentration; Mixed Function Oxygenases; Mutagenesis, Site-Directed; NAD; Oxidation-Reduction; Oxygen; Pseudomonas putida; Spectrophotometry, Ultraviolet; Spectrum Analysis; Structure-Activity Relationship | 1994 |
Site-directed mutagenesis of two conserved charged amino acids in the N-terminal region of alpha subunit of E. coli-F(0)F(1).
Topics: Adenosine Triphosphate; Amino Acid Sequence; Arginine; Aspartic Acid; Base Sequence; Cell Membrane; Conserved Sequence; Dicyclohexylcarbodiimide; Escherichia coli; Hydrolysis; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Oxidation-Reduction; Proton Pumps; Proton-Translocating ATPases | 1996 |
Switch of coenzyme specificity of mouse lung carbonyl reductase by substitution of threonine 38 with aspartic acid.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductases; Animals; Aspartic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Lung; Mice; Mutagenesis, Site-Directed; NAD; NADP; Protein Denaturation; Structure-Activity Relationship; Threonine | 1997 |
Fumarate permeation in normal and acidotic rat kidney mitochondria: fumarate/malate and fumarate/aspartate translocators.
Topics: Acidosis; Adenylosuccinate Lyase; Animals; Aspartic Acid; Biological Transport; Carrier Proteins; Fumarates; Kidney; Malates; Male; Mitochondria; NAD; NADP; Oxaloacetates; Rats; Rats, Wistar | 1998 |
Ontogeny of malate-aspartate shuttle capacity and gene expression in cardiac mitochondria.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Base Sequence; Biological Transport; DNA, Complementary; Down-Regulation; Gene Expression; Malate Dehydrogenase; Malates; Mitochondria, Heart; Molecular Sequence Data; NAD; RNA, Messenger; Swine | 1998 |
Roles of negatively charged surface residues of putidaredoxin in interactions with redox partners in p450cam monooxygenase system.
Topics: Aspartic Acid; Binding Sites; Camphor 5-Monooxygenase; Electricity; Electron Transport; Ferredoxins; Glutamic Acid; Models, Molecular; Mutagenesis, Site-Directed; NAD; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Potentiometry; Protein Binding; Protein Structure, Secondary; Spectrophotometry | 1998 |
Metabolic modulation of cellular redox potential can improve cardiac recovery from ischemia-reperfusion injury.
Topics: Animals; Aspartic Acid; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; NAD; Oxidation-Reduction; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Xanthines | 1998 |
Malate-aspartate shuttle, cytoplasmic NADH redox potential, and energetics in vascular smooth muscle.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Biological Transport; Cytoplasm; Energy Metabolism; Glucose; Malates; Mitochondria, Muscle; Muscle Contraction; Muscle, Smooth, Vascular; NAD; Oxidation-Reduction; Oxygen Consumption; Phosphates; Swine | 1998 |
Structural basis of substrate specificity in malate dehydrogenases: crystal structure of a ternary complex of porcine cytoplasmic malate dehydrogenase, alpha-ketomalonate and tetrahydoNAD.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Crystallography, X-Ray; Cytoplasm; Histidine; Malate Dehydrogenase; Malonates; Molecular Sequence Data; NAD; Protein Conformation; Protein Structure, Secondary; Substrate Specificity; Swine | 1999 |
Direct measurement of the pKa of aspartic acid 26 in Lactobacillus casei dihydrofolate reductase: implications for the catalytic mechanism.
Topics: Apoenzymes; Aspartic Acid; Catalysis; Folic Acid; Hydrogen-Ion Concentration; Lacticaseibacillus casei; Macromolecular Substances; NAD; Tetrahydrofolate Dehydrogenase | 1999 |
A change in reaction specificity of sheep liver serine hydroxymethyltransferase. Induction of NADH oxidation upon mutation of His230 to Tyr.
Topics: Amino Acid Substitution; Animals; Aspartate Aminotransferases; Aspartic Acid; Electrons; Free Radical Scavengers; Glycine Hydroxymethyltransferase; Kinetics; Liver; Mannitol; Mutation; NAD; Nitroblue Tetrazolium; Oxidation-Reduction; Recombinant Proteins; Sheep; Spectrophotometry, Ultraviolet; Substrate Specificity; Superoxide Dismutase | 2000 |
Roles of his205, his296, his303 and Asp259 in catalysis by NAD+-specific D-lactate dehydrogenase.
Topics: Amino Acid Substitution; Aspartic Acid; Bacterial Proteins; Binding Sites; Catalysis; Histidine; Hydrogen-Ion Concentration; Kinetics; L-Lactate Dehydrogenase; Lactate Dehydrogenases; Lactobacillus; Models, Molecular; Mutagenesis, Site-Directed; NAD; Point Mutation; Recombinant Fusion Proteins; Structure-Activity Relationship | 2000 |
Identification of the enzymatic active site of CD38 by site-directed mutagenesis.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Affinity Labels; Amino Acid Substitution; Animals; Antigens, CD; Antigens, Differentiation; Aplysia; Aspartic Acid; Azides; Binding Sites; Circular Dichroism; Cloning, Molecular; Crystallography, X-Ray; Humans; Kinetics; Membrane Glycoproteins; Models, Molecular; Mutagenesis, Site-Directed; NAD; NAD+ Nucleosidase; Pichia; Protein Structure, Secondary; Recombinant Proteins | 2000 |
A new class of glutamate dehydrogenases (GDH). Biochemical and genetic characterization of the first member, the AMP-requiring NAD-specific GDH of Streptomyces clavuligerus.
Topics: Adenosine Monophosphate; Allosteric Site; Amino Acid Sequence; Ammonia; Asparagine; Aspartic Acid; Base Sequence; Carbon; Catalysis; Cell Division; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Evolution, Molecular; Glutamate Dehydrogenase; Glycerol; Hydrogen-Ion Concentration; Ketoglutaric Acids; Kinetics; Molecular Sequence Data; Molecular Weight; NAD; Nitrogen; Phylogeny; Polymerase Chain Reaction; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Streptomyces; Temperature; Time Factors; Tricarboxylic Acids | 2000 |
Metabolic adaptation of the hypertrophied heart: role of the malate/aspartate and alpha-glycerophosphate shuttles.
Topics: Adenosine Triphosphate; Animals; Aorta; Aspartic Acid; Atrial Natriuretic Factor; Blotting, Northern; Cardiomegaly; Fatty Acids; Glucose; Glycerophosphates; Immunoblotting; Lactic Acid; Malate Dehydrogenase; Malates; Male; Mitochondria; Models, Biological; Myocardium; NAD; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 2000 |
The nicotinamide biosynthetic pathway is a by-product of the RNA world.
Topics: Aspartic Acid; Dihydroxyacetone; Dihydroxyacetone Phosphate; Glyceraldehyde; Glyceraldehyde 3-Phosphate; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Molecular Structure; NAD; Niacin; Quinolinic Acid; RNA | 2001 |
Flux-balance analysis of mitochondrial energy metabolism: consequences of systemic stoichiometric constraints.
Topics: Adenosine Triphosphate; Aspartic Acid; Citric Acid Cycle; Energy Metabolism; Fatty Acids, Nonesterified; Flavin-Adenine Dinucleotide; Fumarate Hydratase; Gene Deletion; Glucose; Glycerophosphates; Glycolysis; Humans; Lactic Acid; Malates; Mitochondria; Models, Biological; Mutation; NAD; Oxygen Consumption; Palmitic Acid; Phosphofructokinase-1; Pyruvate Dehydrogenase Complex | 2001 |
Human oestrogenic 17beta-hydroxysteroid dehydrogenase specificity: enzyme regulation through an NADPH-dependent substrate inhibition towards the highly specific oestrone reduction.
Topics: 17-Hydroxysteroid Dehydrogenases; Aspartic Acid; Blood Proteins; Dehydroepiandrosterone; Dihydrotestosterone; Estrogens; Estrone; Female; Humans; Isoenzymes; Leucine; Membrane Proteins; Models, Chemical; NAD; NADP; Oxidation-Reduction; Placenta; Pregnancy | 2001 |
Characterization of mutants of beta histidine91, beta aspartate213, and beta asparagine222, possible components of the energy transduction pathway of the proton-translocating pyridine nucleotide transhydrogenase of Escherichia coli.
Topics: Amino Acid Sequence; Amino Acid Substitution; Asparagine; Aspartic Acid; Binding Sites; Energy Metabolism; Escherichia coli; Histidine; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; NADP; NADP Transhydrogenases; Oxidation-Reduction; Protein Conformation | 2001 |
Folate activation and catalysis in methylenetetrahydrofolate reductase from Escherichia coli: roles for aspartate 120 and glutamate 28.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Catalysis; Enzyme Activation; Escherichia coli; Folic Acid; Glutamic Acid; Glutamine; Kinetics; Methylenetetrahydrofolate Dehydrogenase (NAD+); Methylenetetrahydrofolate Reductase (NADPH2); Mutagenesis, Site-Directed; NAD; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Oxidoreductases; Oxidoreductases Acting on CH-NH Group Donors; Spectrophotometry; Vitamin K | 2001 |
Changes in activities of enzymes related to malate-aspartate shuttle in leukocytes from dogs given a herb supplement.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Blood Glucose; Dietary Supplements; Dogs; Drugs, Chinese Herbal; Fatty Acids, Nonesterified; Female; Glutamate Dehydrogenase; Insulin; L-Lactate Dehydrogenase; Leukocytes; Malate Dehydrogenase; Malates; Male; NAD; Triglycerides | 2001 |
NAD+-dependent DNA ligase encoded by a eukaryotic virus.
Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Aspartic Acid; Base Sequence; Catalysis; Cysteine; DNA Ligases; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Evolution, Molecular; Gene Deletion; Genetic Vectors; Models, Biological; Molecular Sequence Data; Mutation; NAD; Phylogeny; Poxviridae; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Substrate Specificity; Time Factors; Tyrosine; Zinc; Zinc Fingers | 2001 |
Activities of enzymes in the malate-aspartate shuttle in the peripheral leukocytes of dogs and cats.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Blood Glucose; Cats; Cytosol; Dogs; Fatty Acids, Nonesterified; Female; Gene Expression; Glutamate Dehydrogenase; Insulin; L-Lactate Dehydrogenase; Leukocytes; Malate Dehydrogenase; Malates; Male; Mitochondria; NAD; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triglycerides | 2001 |
Conserved residues in domain Ia are required for the reaction of Escherichia coli DNA ligase with NAD+.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; DNA Ligases; Dose-Response Relationship, Drug; Escherichia coli; Gene Deletion; Histidine; Kinetics; Ligands; Models, Biological; Molecular Sequence Data; Mutation; NAD; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Structure-Activity Relationship; Time Factors; Tyrosine | 2002 |
Catalytic mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.
Topics: Adenosylhomocysteinase; Animals; Apoenzymes; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Cattle; Circular Dichroism; Crystallography, X-Ray; DNA, Complementary; Escherichia coli; Holoenzymes; Hydrolases; Hydrolysis; Kinetics; Liver; Lysine; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; NAD; NADP; Protein Binding; Rats; Time Factors; Ultraviolet Rays | 2002 |
Anionic substitutes for catalytic aspartic acids in phosphoribulokinase.
Topics: Adenosine Triphosphate; Amino Acid Substitution; Anions; Aspartic Acid; Catalytic Domain; Cysteine; Fluorescent Dyes; Kinetics; Models, Molecular; Mutagenesis; NAD; Phosphotransferases (Alcohol Group Acceptor); Protein Conformation; Recombinant Proteins | 2002 |
Glutamate-115 renders specificity of human 11beta-hydroxysteroid dehydrogenase type 2 for the cofactor NAD+.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Amino Acid Sequence; Aspartic Acid; Binding Sites; Catalytic Domain; Computer Simulation; Glutamates; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; NADP; Phenylalanine; Protein Conformation; Sequence Homology, Amino Acid | 2003 |
Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase.
Topics: Amino Acid Sequence; Amino Acid Substitution; Arginine; Aspartic Acid; Coenzymes; Female; Humans; Kinetics; Male; Models, Molecular; Molecular Sequence Data; Multienzyme Complexes; Mutagenesis, Site-Directed; NAD; Placenta; Pregnancy; Progesterone Reductase; Protein Conformation; Recombinant Proteins; Steroid Isomerases; Substrate Specificity; Tumor Cells, Cultured | 2003 |
SPECIFICITY OF THE SOLUBLE RNA IN THE CODING OF THE AMINO ACIDS.
Topics: Amino Acids; Animals; Aspartic Acid; Citric Acid Cycle; Guinea Pigs; Liver; Malate Dehydrogenase; NAD; Proteins; Research; RNA | 1963 |
SYNTHESIS OF GLUTAMATE FROM ALPHA-OXOGLUTARATE AND AMMONIA IN RAT-LIVER MITOCHONDRIA. III. MALATE AS HYDROGEN DONOR.
Topics: Adenosine Triphosphate; Ammonia; Amobarbital; Anti-Bacterial Agents; Aspartic Acid; Dinitrophenols; Enzyme Inhibitors; Glutamates; Glutamic Acid; Hydrogen; Ketoglutaric Acids; Liver; Malates; Mitochondria; Mitochondria, Liver; NAD; Oligomycins; Pharmacology; Rats; Research | 1963 |
[NATURE OF THE ENZYME SYSTEMS RESPONSIBLE FOR NITROGEN-SOURCE AMINO ACID UTILIZATION IN BACILLUS SUBTILIS].
Topics: Alanine; Amidohydrolases; Amino Acid Oxidoreductases; Amino Acids; Aspartic Acid; Bacillus subtilis; Caproates; Glutamates; Isoleucine; Ketoglutaric Acids; Leucine; NAD; Nitrogen; Oxidoreductases; Proteins; Pyruvates; Research; Transaminases; Valerian; Valine | 1964 |
WATER CONTENT OF PAPER AS A VARIABLE IN PAPER CHROMATOGRAPHY.
Topics: Adenine; Adenine Nucleotides; Adenosine Triphosphate; Aspartic Acid; Autoradiography; Carbon Isotopes; Chromatography; Chromatography, Paper; Escherichia coli; Formates; Fumarates; Glutamates; Glutamine; Guanine Nucleotides; Humidity; Hypoxanthines; Lactates; Malates; NAD; Nucleosides; Nucleotides; Research; Water; Xanthines | 1964 |
THE FLUOROMETRIC DETERMINATION OF ACETYLCHOLINE.
Topics: Acetates; Acetone; Acetylcholine; Alcohol Oxidoreductases; Amino Acids; Aspartic Acid; Borates; Choline; Coenzyme A; Fluorescence; Fluorometry; Metabolism; NAD; Research; Spectrophotometry | 1964 |
AMINO GROUP FORMATION AND GLUTAMATE SYNTHESIS IN STREPTOCOCCUS BOVIS.
Topics: Amino Acids; Asparagine; Aspartic Acid; Carbon; Caseins; Culture Media; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Glyceraldehyde-3-Phosphate Dehydrogenases; Isocitrate Dehydrogenase; Metabolism; NAD; NADP; Nitrogen; Nucleotides; Research; Streptococcus; Streptococcus bovis | 1964 |
[ROLE OF GLUTAMIC DEHYDROGENASE AND ASPARTIC/GLUTAMIC TRANSAMINASE IN THE OXIDATION OF GLUTAMATE BY SARCOSOMES FROM PIG HEART AND UTERUS].
Topics: Amino Acids; Animals; Antimetabolites; Arsenicals; Aspartate Aminotransferases; Aspartic Acid; Chromatography; Cytoplasmic Granules; Female; Formates; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Humans; Malonates; Manometry; Metabolism; Mitochondria, Muscle; Muscle, Smooth; Myocardium; NAD; Pharmacology; Research; Swine; Uterus | 1964 |
ALCOHOL HYPOGLYCEMIA. II. A POSTULATED MECHANISM OF ACTION BASED ON EXPERIMENTS WITH RAT LIVER SLICES.
Topics: Alanine; Amino Acids; Aspartic Acid; Autoradiography; Carbohydrate Metabolism; Carbon Dioxide; Carbon Isotopes; Chromatography; Citric Acid Cycle; Ethanol; Fructose; Glucose; Glycerophosphates; Hypoglycemia; Lactates; Liver; Mitochondria; NAD; Oxidoreductases; Pyruvates; Rats; Research; Sorbitol | 1965 |
PHOSPHOENOLPYRUVATE CARBOXYLASE ACTIVITY AND GLYCOGENESIS IN THE FLATWORM, HYMENOLEPIS DIMINUTA.
Topics: Adenosine Triphosphate; Alanine; Alcohol Oxidoreductases; Animals; Aspartic Acid; Carbohydrate Metabolism; Carbon Dioxide; Carboxy-Lyases; Cestoda; Citric Acid Cycle; Dialysis; Fumarates; Glutamates; Glycogen; Glycolysis; Hymenolepis diminuta; Keto Acids; Lactates; Malates; NAD; NADP; Oxaloacetates; Phosphoenolpyruvate Carboxylase; Platyhelminths; Pyruvates; Renal Dialysis; Research; Succinates | 1965 |
Slc25a13-knockout mice harbor metabolic deficits but fail to display hallmarks of adult-onset type II citrullinemia.
Topics: Amino Acids; Ammonia; Animals; Argininosuccinate Synthase; Aspartic Acid; Base Sequence; Citrullinemia; Disease Models, Animal; DNA; Female; Gluconeogenesis; Humans; Liver; Male; Membrane Transport Proteins; Mice; Mice, Knockout; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Mutation; NAD; Phenotype; RNA, Messenger; Urea | 2004 |
Involvement of a Glu71-Arg64 couple in the access channel for NADH in cytochrome p450nor.
Topics: Amino Acid Substitution; Arginine; Aspartic Acid; Cytochrome P-450 Enzyme System; Fusarium; Glutamic Acid; Heme; Molecular Structure; NAD; Oxidoreductases; Point Mutation | 2004 |
D88A mutant of cytochrome P450nor provides kinetic evidence for direct complex formation with electron donor NADH.
Topics: Animals; Aspartic Acid; Bacterial Proteins; Binding Sites; Chlorides; Cytochrome P-450 Enzyme System; Macromolecular Substances; Models, Molecular; Mutagenesis, Site-Directed; NAD; Oxidoreductases; Point Mutation; Protein Structure, Tertiary | 2004 |
Cerebral oxidative stress and depression of energy metabolism correlate with severity of diffuse brain injury in rats.
Topics: Animals; Ascorbic Acid; Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Brain Injuries; Chromatography, High Pressure Liquid; Energy Metabolism; Head Injuries, Closed; Hypotension; Hypoxia; Male; Malondialdehyde; NAD; NADP; Nucleosides; Oxidative Stress; Phosphates; Purines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2005 |
A catalytic triad is responsible for acid-base chemistry in the Ascaris suum NAD-malic enzyme.
Topics: Animals; Arginine; Ascaris suum; Aspartic Acid; Catalytic Domain; Deuterium Exchange Measurement; Hydrogen-Ion Concentration; Kinetics; Lysine; Malate Dehydrogenase; Models, Chemical; NAD; Phenylalanine; Spectrophotometry; Substrate Specificity; Tyrosine | 2005 |
Aspartate 120 of Escherichia coli methylenetetrahydrofolate reductase: evidence for major roles in folate binding and catalysis and a minor role in flavin reactivity.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Alanine; Asparagine; Aspartic Acid; Catalysis; Cold Temperature; Escherichia coli Proteins; Flavin-Adenine Dinucleotide; Folic Acid; Imines; Kinetics; Lysine; Mutagenesis, Site-Directed; NAD; Oxidation-Reduction; Potentiometry; Spectrophotometry; Substrate Specificity; Thermodynamics | 2005 |
Possible involvement of glutamic and/or aspartic acid residue(s) and requirement of mitochondrial integrity for the protective effect of creatine against inhibition of cardiac mitochondrial respiration by methylglyoxal.
Topics: Alamethicin; Animals; Aspartic Acid; Binding Sites; Cell Respiration; Creatine; Electron Transport Complex I; Glutamic Acid; Goats; Intracellular Membranes; Isoxazoles; Mitochondria, Heart; NAD; NADH Dehydrogenase; Oxygen Consumption; Permeability; Protective Agents; Pyruvaldehyde; Submitochondrial Particles | 2005 |
Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: insights from in silico studies.
Topics: Animals; Aspartic Acid; Computer Simulation; Cytosol; Energy Metabolism; Glycolysis; Humans; Ischemia; Kinetics; Lactic Acid; Malates; Mitochondria; Models, Biological; Myocardial Ischemia; Myocardium; NAD; Oxidation-Reduction; Oxygen Consumption | 2005 |
Early steps in the biosynthesis of NAD in Arabidopsis start with aspartate and occur in the plastid.
Topics: Amino Acid Oxidoreductases; Arabidopsis; Aspartic Acid; Escherichia coli; Escherichia coli Proteins; Multienzyme Complexes; NAD; Pentosyltransferases; Plastids; Quinolinic Acid | 2006 |
Mitochondria from the left heart ventricles of both normotensive and spontaneously hypertensive rats oxidize externally added NADH mostly via a novel malate/oxaloacetate shuttle as reconstructed in vitro.
Topics: Animals; Aspartic Acid; Blood Pressure; Glycerophosphates; Heart Ventricles; Kinetics; Malate Dehydrogenase; Malates; Male; Mitochondria, Heart; Models, Biological; Models, Chemical; NAD; NADP; Oxaloacetic Acid; Oxidation-Reduction; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Statistics as Topic | 2006 |
The importance of redox shuttles to pancreatic beta-cell energy metabolism and function.
Topics: Animals; Aspartic Acid; Cytosol; Energy Metabolism; Flavin-Adenine Dinucleotide; Glucose; Glycerophosphates; Insulin; Insulin Secretion; Insulin-Secreting Cells; Malates; Mitochondria; Models, Biological; NAD; Oxidation-Reduction | 2006 |
Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttle.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Brain; Calcium; Glutamic Acid; Kinetics; Malates; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mitochondria, Heart; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Molecular Sequence Data; Muscle, Skeletal; NAD | 2007 |
Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase.
Topics: Adenosine Diphosphate; Asparagine; Aspartic Acid; Catalytic Domain; Humans; Isocitrate Dehydrogenase; Mutagenesis, Site-Directed; NAD; Protein Subunits; Structure-Activity Relationship; Substrate Specificity | 2007 |
Crystal structure of archaeal highly thermostable L-aspartate dehydrogenase/NAD/citrate ternary complex.
Topics: Amino Acid Oxidoreductases; Amino Acid Sequence; Archaeal Proteins; Archaeoglobus fulgidus; Aspartic Acid; Binding Sites; Citric Acid; Crystallography, X-Ray; Enzyme Stability; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; NAD; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Substrate Specificity; Thermodynamics | 2007 |
NAD kinases use substrate-assisted catalysis for specific recognition of NAD.
Topics: Amino Acid Motifs; Amino Acid Substitution; Aspartic Acid; Bacterial Proteins; Catalysis; Crystallography, X-Ray; Diacylglycerol Kinase; Listeria monocytogenes; Magnesium; Mutation, Missense; NAD; Phosphofructokinase-1; Phosphotransferases (Alcohol Group Acceptor); Structure-Activity Relationship; Substrate Specificity | 2007 |
The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast.
Topics: Aspartate Aminotransferases; Aspartic Acid; Biological Transport; Blotting, Western; Cell Nucleus; Cytoplasm; Electron Transport; Energy Metabolism; Fungal Proteins; Glycerolphosphate Dehydrogenase; Malate Dehydrogenase; Malates; Mitochondria; Mutation; NAD; Saccharomyces cerevisiae; Signal Transduction; Time Factors; Yeasts | 2008 |
Conserved water mediated H-bonding dynamics of inhibitor, cofactor, Asp 364 and Asn 303 in human IMPDH II.
Topics: Asparagine; Aspartic Acid; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Enzyme Stability; Humans; Hydrogen Bonding; IMP Dehydrogenase; Inosine Monophosphate; Ligands; NAD; Thermodynamics; Water | 2009 |
Calcium signaling in brain mitochondria: interplay of malate aspartate NADH shuttle and calcium uniporter/mitochondrial dehydrogenase pathways.
Topics: Animals; Aspartic Acid; Brain; Calcium; Calcium Channels; Calcium Signaling; Cytosol; Ketoglutaric Acids; Malates; Mice; Mitochondria, Heart; Mitochondrial Proteins; NAD; Organic Anion Transporters | 2009 |
Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured neurons.
Topics: 3-Hydroxybutyric Acid; Animals; Aspartic Acid; Brain Chemistry; Cells, Cultured; Cerebellum; Cytosol; Energy Metabolism; Glucose; Glutamic Acid; Ketone Bodies; Malate Dehydrogenase; Mice; NAD; Neurons; Neurotransmitter Agents; Subcellular Fractions; Synaptic Transmission | 2009 |
The unique kinetic behavior of the very large NAD-dependent glutamate dehydrogenase from Janthinobacterium lividum.
Topics: Aspartic Acid; Catalysis; Chromobacterium; Glutamate Dehydrogenase; Glutamic Acid; Ketoglutaric Acids; Kinetics; NAD; Oxalobacteraceae | 2010 |
Synthesizing and salvaging NAD: lessons learned from Chlamydomonas reinhardtii.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; Biological Evolution; Biosynthetic Pathways; Chlamydomonas reinhardtii; Gene Expression Regulation; Gene Expression Regulation, Plant; Genes, Plant; Mammals; Molecular Sequence Data; Mutagenesis, Insertional; Mutation; NAD; Niacinamide; Nicotinamide-Nucleotide Adenylyltransferase; Phenotype; Plant Proteins; Pyridines; Time Factors; Transcription, Genetic | 2010 |
Visible wavelength spectrophotometric assays of L-aspartate and D-aspartate using hyperthermophilic enzyme systems.
Topics: Acetic Acid; Amino Acid Isomerases; Amino Acid Oxidoreductases; Animals; Aspartic Acid; D-Aspartic Acid; Escherichia coli Proteins; Isomerism; Liver; Methylphenazonium Methosulfate; Mice; NAD; Oxidation-Reduction; Spectrophotometry; Swine | 2011 |
A novel L-aspartate dehydrogenase from the mesophilic bacterium Pseudomonas aeruginosa PAO1: molecular characterization and application for L-aspartate production.
Topics: Amino Acid Oxidoreductases; Aspartic Acid; Cloning, Molecular; Coenzymes; Enzyme Stability; Escherichia coli; Kinetics; Molecular Weight; NAD; NADP; Oxaloacetic Acid; Protein Multimerization; Pseudomonas aeruginosa; Recombinant Proteins; Substrate Specificity; Temperature | 2011 |
Brain energy depletion in a rodent model of diffuse traumatic brain injury is not prevented with administration of sodium lactate.
Topics: Adenosine Triphosphate; Animals; Ascorbic Acid; Aspartic Acid; Blood Gas Analysis; Blood Pressure; Brain Chemistry; Brain Injuries; Cerebral Cortex; Chromatography, High Pressure Liquid; Disease Models, Animal; Energy Metabolism; Glutathione; Male; Models, Biological; NAD; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sodium Lactate | 2011 |
A non-NadB type L-aspartate dehydrogenase from Ralstonia eutropha strain JMP134: molecular characterization and physiological functions.
Topics: Amino Acid Oxidoreductases; Aspartate Aminotransferases; Aspartic Acid; Bacterial Proteins; Cloning, Molecular; Cupriavidus necator; Dimerization; Escherichia coli; Gene Deletion; Gene Expression; Hydroxybutyrates; Kinetics; Mass Spectrometry; NAD; NADP; Polyesters; Real-Time Polymerase Chain Reaction; Recombinant Proteins; Transformation, Bacterial | 2011 |
Malate-aspartate shuttle and exogenous NADH/cytochrome c electron transport pathway as two independent cytosolic reducing equivalent transfer systems.
Topics: Animals; Apoptosis; Aspartic Acid; Biological Transport, Active; Cytochromes c; Electron Transport; Glutamate Dehydrogenase; Ketoglutaric Acids; Malates; Mitochondria, Liver; Mitochondrial Proteins; NAD; Oxidation-Reduction; Rats | 2012 |
Aralar mRNA and protein levels in neurons and astrocytes freshly isolated from young and adult mouse brain and in maturing cultured astrocytes.
Topics: Aging; Animals; Aspartic Acid; Astrocytes; Brain; Cell Separation; Cells, Cultured; Cellular Senescence; Cytoplasm; Energy Metabolism; Female; Glutamic Acid; Lactic Acid; Male; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Membrane Transport Proteins; NAD; Nerve Tissue Proteins; Neurons; Oxidation-Reduction; Primary Cell Culture; Pyruvic Acid; Real-Time Polymerase Chain Reaction; RNA, Messenger | 2012 |
Exploring the molecular basis for selective binding of homoserine dehydrogenase from Mycobacterium leprae TN toward inhibitors: a virtual screening study.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Catalytic Domain; Enzyme Inhibitors; Homoserine Dehydrogenase; Humans; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Sequence Data; Mycobacterium leprae; NAD; Protein Conformation; Reproducibility of Results; ROC Curve; Sequence Alignment; Substrate Specificity | 2014 |
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Topics: Adenosine Monophosphate; Animals; Aspartic Acid; Citric Acid Cycle; Disease Models, Animal; Electron Transport; Electron Transport Complex I; Fumarates; Ischemia; Malates; Male; Metabolomics; Mice; Mitochondria; Myocardial Infarction; Myocardium; Myocytes, Cardiac; NAD; Reactive Oxygen Species; Reperfusion Injury; Stroke; Succinate Dehydrogenase; Succinic Acid | 2014 |
Impaired cytosolic NADH shuttling and elevated UCP3 contribute to inefficient citric acid cycle flux support of postischemic cardiac work in diabetic hearts.
Topics: Animals; Aspartic Acid; Carbon-13 Magnetic Resonance Spectroscopy; Carrier Proteins; Citric Acid Cycle; Cytosol; Diabetes Mellitus, Experimental; Hemodynamics; Ion Channels; Malates; Male; Mice, Inbred C57BL; Mitochondrial Proteins; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; NAD; Oxidation-Reduction; Perfusion; PPAR alpha; Uncoupling Protein 2; Uncoupling Protein 3 | 2015 |
SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth.
Topics: Acetylation; Animals; Aspartate Aminotransferase, Mitochondrial; Aspartic Acid; Biological Transport; Carcinoma, Pancreatic Ductal; Cell Proliferation; Cells, Cultured; HEK293 Cells; Humans; Malates; Male; Mice; Mice, Inbred C57BL; Mice, Nude; NAD; Oxidation-Reduction; Pancreatic Neoplasms; Protein Processing, Post-Translational; Sirtuin 3 | 2015 |
Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain.
Topics: Acetylcholine; Aging; Animals; Antioxidants; Aspartic Acid; Brain; Carnitine; DNA Damage; DNA Polymerase gamma; DNA-Directed DNA Polymerase; DNA, Mitochondrial; Female; Glutamates; Male; Metabolomics; Mice; Mutation; NAD; Neurotransmitter Agents; Physical Conditioning, Animal; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases | 2015 |
Respiration and substrate transport rates as well as reactive oxygen species production distinguish mitochondria from brain and liver.
Topics: Animals; Aspartic Acid; Biological Transport; Brain; Cell Respiration; Dicarboxylic Acid Transporters; Electron Transport Chain Complex Proteins; Enzyme Inhibitors; Gene Expression Regulation; Glutamic Acid; Kinetics; Liver; Malates; Membrane Potential, Mitochondrial; Mice; Mitochondria, Liver; NAD; Organ Specificity; Reactive Oxygen Species; Succinic Acid | 2015 |
Dual activity of quinolinate synthase: triose phosphate isomerase and dehydration activities play together to form quinolinate.
Topics: Aspartic Acid; Bacterial Proteins; Dihydroxyacetone Phosphate; Metabolic Networks and Pathways; Models, Chemical; Multienzyme Complexes; NAD; Quinolinic Acid; Thermotoga maritima; Triose-Phosphate Isomerase | 2015 |
Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion.
Topics: Action Potentials; Adenosine Triphosphate; Aldehyde Dehydrogenase; Animals; Aspartic Acid; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cytosol; Female; Gossypol; Humans; Lung Neoplasms; Malates; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; NAD; NADP; Neoplasm Transplantation; Oxidative Phosphorylation; Oxidoreductases Acting on CH-NH Group Donors; Phenformin; RNA, Small Interfering | 2016 |
Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.
Topics: Animals; Aspartic Acid; Cell Line, Tumor; Cell Proliferation; Electron Transport Complex I; Homeostasis; Humans; Metformin; Mice, Nude; Mitochondria; NAD; Neoplasms; Pyruvic Acid; Tumor Microenvironment | 2016 |
Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC.
Topics: A549 Cells; Adenosine Triphosphate; Animals; Aspartic Acid; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Death; Cell Proliferation; Cell Survival; Cytosol; Drug Synergism; Fluorouracil; Gene Knockdown Techniques; Glutamic Acid; Glutaminase; Glutamine; Lung Neoplasms; Malates; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy; NAD; Oxidation-Reduction; Sulfides; Thiadiazoles; Thymidylate Synthase; Xenograft Model Antitumor Assays | 2016 |
Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD
Topics: Adenosine Triphosphate; Aspartic Acid; Cell Death; Culture Media; Electron Transport Complex I; Fibroblasts; Galactose; Gene Expression; Glycolysis; Humans; Ketoglutaric Acids; Leigh Disease; Malates; Mitochondria; Mitochondrial Diseases; Mutation; NAD; NADH Dehydrogenase; Oxaloacetic Acid; Primary Cell Culture; Pyruvic Acid; Skin | 2018 |
Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism.
Topics: Animals; Aspartic Acid; Cells, Cultured; Fructose-Bisphosphatase; Gluconeogenesis; Glucose; Glycolysis; Hepatocytes; Hypoglycemic Agents; Lactic Acid; Malates; Male; Metformin; Mice; Mice, Inbred C57BL; Mitochondria, Liver; NAD; Oxidation-Reduction; Phosphofructokinase-1; Rats; Rats, Wistar | 2019 |
Malate-aspartate shuttle promotes l-lactate oxidation in mitochondria.
Topics: Aspartic Acid; Colonic Neoplasms; HCT116 Cells; Homeostasis; Humans; Lactic Acid; Malates; Mitochondria; NAD; Oxidation-Reduction; Oxidative Phosphorylation; Warburg Effect, Oncologic | 2020 |
MDH1-mediated malate-aspartate NADH shuttle maintains the activity levels of fetal liver hematopoietic stem cells.
Topics: Animals; Aspartic Acid; Fetus; Hematopoietic Stem Cells; Liver; Malates; Metabolomics; Mice; Mice, Transgenic; NAD; Optical Imaging | 2020 |
Optimal pH shift of the NADH oxidase from Lactobacillus rhamnosus with a single mutation.
Topics: Amino Acid Substitution; Arginine; Aspartic Acid; Bacterial Proteins; Binding Sites; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Lacticaseibacillus rhamnosus; Models, Molecular; Molecular Docking Simulation; Multienzyme Complexes; Mutagenesis, Site-Directed; NAD; NADH, NADPH Oxidoreductases; Protein Conformation; Protein Engineering; Substrate Specificity | 2021 |
Alteration of cofactor specificity of the acrylyl-CoA reductase from Escherichia coli.
Topics: Amino Acid Substitution; Arginine; Aspartic Acid; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Mutagenesis, Site-Directed; NAD; NADP; Protein Engineering; Quinone Reductases; Serine; Substrate Specificity | 2021 |
Expression, purification, and biochemical characterization of an NAD
Topics: Amino Acid Sequence; Aspartic Acid; Bacterial Proteins; Burkholderiaceae; Chromatography, Gel; Cloning, Molecular; Escherichia coli; Euplotes; Gene Expression; Genetic Vectors; Homoserine; Homoserine Dehydrogenase; Kinetics; Molecular Weight; NAD; NADP; Protein Multimerization; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Small Ubiquitin-Related Modifier Proteins; Symbiosis | 2021 |
Biguanide drugs enhance cytotoxic effects of cisplatin by depleting aspartate and NAD+ in sensitive cancer cells.
Topics: Antineoplastic Agents; Aspartic Acid; Cisplatin; Metformin; NAD; Neoplasms; Pharmaceutical Preparations | 2021 |
Arabidopsis nitrate-induced aspartate oxidase gene expression is necessary to maintain metabolic balance under nitrogen nutrient fluctuation.
Topics: Arabidopsis; Aspartic Acid; Gene Expression; Gene Expression Regulation, Plant; NAD; Nitrates; Nitrogen; Nutrients | 2022 |
Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells.
Topics: Aspartic Acid; Glucose; Glycolysis; Lactic Acid; Malates; NAD | 2022 |
Hypoxia-responsive nanocarriers for chemotherapy sensitization via dual-mode inhibition of hypoxia-inducible factor-1 alpha.
Topics: Antineoplastic Agents; Aspartic Acid; Caspase 3; Cell Hypoxia; Cell Line, Tumor; Cytochromes c; Dicumarol; Female; Glutathione; Humans; Hypoxia; Micelles; NAD; NADP; Nitroimidazoles; Oxygen; Phosphates; Polyethylene Glycols; Polymers; Quinones; Sorafenib; Thioredoxins | 2022 |
Reversible Glutamate Coordination to High-Valent Nickel Protects the Active Site of a [NiFe] Hydrogenase from Oxygen.
Topics: Alanine; Aspartic Acid; Catalytic Domain; Glutamic Acid; Glutamine; Hydrogenase; Hydrogenophilaceae; Iron; Ligands; NAD; Nickel; Oxidation-Reduction; Oxygen | 2022 |
Nicotinamide riboside rescues dysregulated glycolysis and fatty acid β-oxidation in a human hepatic cell model of citrin deficiency.
Topics: Aspartic Acid; Citrullinemia; Fatty Acids; Glycolysis; Hepatocytes; Humans; Hyperammonemia; Malates; Mitochondrial Membrane Transport Proteins; NAD; Urea | 2023 |
Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells.
Topics: Aspartic Acid; Citric Acid Cycle; Humans; NAD; Oxidation-Reduction; Succinate Dehydrogenase | 2023 |
The mitochondrial NADH shuttle system is a targetable vulnerability for Group 3 medulloblastoma in a hypoxic microenvironment.
Topics: Aspartic Acid; Cerebellar Neoplasms; Child; Humans; Hypoxia; Malates; Medulloblastoma; NAD; Oxygen; Tumor Microenvironment | 2023 |