naamidine-a and 2-aminoimidazole

naamidine-a has been researched along with 2-aminoimidazole* in 1 studies

Other Studies

1 other study(ies) available for naamidine-a and 2-aminoimidazole

Article	Year
Synthesis of Naamidine A and Selective Access to N(2)-Acyl-2-aminoimidazole Analogues. The Journal of organic chemistry, 2015, Oct-16, Volume: 80, Issue:20 A short and scalable synthesis of naamidine A, a marine alkaloid with a selective ability to inhibit epidermal growth factor receptor (EGFR)-dependent cellular proliferation, has been achieved. A key achievement in this synthesis was the development of a regioselective hydroamination of a monoprotected propargylguanidine to deliver N(3)-protected cyclic ene-guanidines. This permits the extension of this methodology to prepare N(2)-acyl analogues in a fashion that obviates the troublesome acylation of the free 2-aminoimidazoles, which typically yields mixtures of N(2)- and N(2),N(2)-diacylated products. Topics: Acylation; Alkaloids; Amination; Animals; ErbB Receptors; Guanidines; Imidazoles	2015

Article

Year

Synthesis of Naamidine A and Selective Access to N(2)-Acyl-2-aminoimidazole Analogues.

The Journal of organic chemistry, 2015, Oct-16, Volume: 80, Issue:20

A short and scalable synthesis of naamidine A, a marine alkaloid with a selective ability to inhibit epidermal growth factor receptor (EGFR)-dependent cellular proliferation, has been achieved. A key achievement in this synthesis was the development of a regioselective hydroamination of a monoprotected propargylguanidine to deliver N(3)-protected cyclic ene-guanidines. This permits the extension of this methodology to prepare N(2)-acyl analogues in a fashion that obviates the troublesome acylation of the free 2-aminoimidazoles, which typically yields mixtures of N(2)- and N(2),N(2)-diacylated products.

Topics: Acylation; Alkaloids; Amination; Animals; ErbB Receptors; Guanidines; Imidazoles

2015