naadp has been researched along with nadp in 403 studies
| Studies (naadp) | Trials (naadp) | Recent Studies (post-2010) (naadp) | Studies (nadp) | Trials (nadp) | Recent Studies (post-2010) (nadp) |
|---|---|---|---|---|---|
| 411 | 0 | 184 | 21,608 | 25 | 3,484 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.25) | 18.7374 |
| 1990's | 29 (7.20) | 18.2507 |
| 2000's | 162 (40.20) | 29.6817 |
| 2010's | 181 (44.91) | 24.3611 |
| 2020's | 30 (7.44) | 2.80 |
| Authors | Studies |
|---|---|
| Bernofsky, C | 1 |
| Beers, KW; Chini, CC; Chini, EN; Dousa, TP | 1 |
| Chini, EN; Dousa, TP | 3 |
| Aarhus, R; Lee, HC | 4 |
| Beers, KW; Chini, EN; Dousa, TP | 2 |
| Chini, EN; Clapham, DE; Dousa, TP; Perez-Terzic, CM; Shen, SS | 1 |
| Aarhus, R; Dickey, DM; Gee, KR; Graeff, RM; Lee, HC; Walseth, TF | 1 |
| Galione, A; Genazzani, AA | 2 |
| Empson, RM; Galione, A; Genazzani, AA | 1 |
| Aarhus, R; Gee, KR; Kestner, T; Lee, HC | 1 |
| Galione, A; Genazzani, AA; Mezna, M; Michelangeli, F; Summerhill, RJ | 1 |
| Coyle, DL; Jacobson, EL; Jacobson, MK; Kim, H; Vu, CQ | 1 |
| Dickey, DM; Galione, A; Genazzani, AA; Mezna, M; Michelangeli, F; Walseth, TF | 1 |
| Lee, HC | 10 |
| De Flora, A; Franco, L; Graeff, RM; Lee, HC | 1 |
| Albrieux, M; Lee, HC; Villaz, M | 1 |
| Biancani, P | 1 |
| Gee, KR; Lee, HC | 1 |
| Dobashi, K; Horie, T; Iizuka, K; Mori, M; Nakazawa, T; Yoshii, A | 1 |
| Chini, EN; Dousa, TP; Liang, M | 1 |
| Dubé, F; Eckberg, WR; Galione, A; Thomas, TW | 1 |
| Cancela, JM; Churchill, GC; Galione, A | 1 |
| Graeff, R; Lee, HC; Munshi, C | 1 |
| Cheng, J; Chini, EN; Dousa, TP; Liang, M | 1 |
| Carafoli, E; De Riso, L; Genazzani, AA; Kyozuka, K; Santella, L | 1 |
| Gylfe, E; Hellman, B; Tengholm, A | 1 |
| Cancela, JM; Gerasimenko, JV; Gerasimenko, OV; Petersen, OH; Tepikin, AV | 1 |
| Bewell, MA; Dickinson, GD; Galione, A; Navazio, L; Sanders, D; Siddiqua, A | 1 |
| Berg, I; Guse, AH; Mayr, GW; Potter, BV | 1 |
| Burdakov, D; Galione, A | 1 |
| Billington, RA; Genazzani, AA | 3 |
| Churchill, GC; Galione, A | 3 |
| Churchill, GC; Galione, A; Patel, S; Sharp, T | 1 |
| Churchill, GC; Galione, A; Patel, S | 3 |
| da Silva, CP; Guse, AH | 1 |
| Cheng, J; Chini, EN; Grande, JP; Thompson, MA; Yusufi, ANK | 1 |
| Cheng, J; Chini, EN; Grande, JP; Thompson, MA; Yusufi, AN | 1 |
| Gallacher, DV; Harmer, AR; Smith, PM | 1 |
| Cancela, JM | 1 |
| Komínková, V; Krizanová, O; Mojzisová, A; Ondrias, K; Záciková, L | 1 |
| Petty, HR | 1 |
| Li, X; Mohanty, MJ; Rossi, NF; Ye, M | 1 |
| Bak, J; Billington, RA; Dutton, AC; Genazzani, AA; Timar, G | 1 |
| Brailoiu, E; Dun, NJ; Miyamoto, MD | 1 |
| Copello, JA; Fleischer, S; Jeyakumar, LH; Ogunbunmi, E; Qi, Y | 1 |
| Carafoli, E; Gragnaniello, G; Kyozuka, K; Lim, D; Santella, L | 1 |
| Grafton, G; Thwaite, L | 1 |
| Baux, G; Chameau, P; Fossier, P; Van de Vrede, Y | 1 |
| Burnett, JC; Cheng, J; Grande, JP; Thompson, MA; Yusufi, AN | 1 |
| Lim, D; Nusco, GA; Sabala, P; Santella, L | 1 |
| Gobel, A; Krause, E; Schulz, I | 1 |
| Chini, CC; Chini, EN; Kato, I; Okamoto, H; Takasawa, S | 1 |
| Cancela, JM; Galione, A; Petersen, OH; Tepikin, AV; Van Coppenolle, F | 1 |
| Berridge, G; Cramer, R; Galione, A; Patel, S | 1 |
| Chini, EN; De Toledo, FG | 1 |
| Chini, EN | 2 |
| Ohno, K; Sahashi, K; Tanaka, M | 1 |
| Guse, AH | 7 |
| Drobny, H; Gscheidlinger, R; Hohenegger, M; Suko, J; Zidar, A | 1 |
| Li, X; Mohanty, MJ | 1 |
| Graeff, R; Lee, HC | 1 |
| Genazzani, AA; Thorn, P | 1 |
| Bak, J; Billington, RA; Genazzani, AA | 1 |
| Berridge, G; Dickinson, G; Galione, A; Parrington, J; Patel, S | 1 |
| Billington, RA; Genazzani, AA; Ho, A | 1 |
| Johnson, JD; Misler, S | 1 |
| Churchill, GC; Galione, A; Genazzani, AA; Okada, Y; Patel, S; Thomas, JM | 1 |
| Boittin, FX; Evans, AM; Galione, A | 1 |
| Lai, FA; Mitchell, KJ; Rutter, GA | 1 |
| Churchill, GC; Galione, A; Genazzani, AA; Masgrau, R; O'Neill, JS; Patel, S; Thomas, JM | 1 |
| Ashcroft, SJ; Churchill, GC; Galione, A; Masgrau, R; Morgan, AJ | 1 |
| Pivovarov, AS; Walker, RJ | 1 |
| Patel, S | 3 |
| Brailoiu, E; Dun, NJ; Patel, S | 1 |
| Graeff, RM; Lee, HC | 2 |
| Cancela, JM; Charpentier, G; Petersen, OH | 1 |
| Dickinson, GD; Patel, S | 1 |
| Ercolano, E; Lim, D; Moccia, F; Nusco, GA; Santella, L | 1 |
| Rutter, GA | 1 |
| Dolman, NJ; Gerasimenko, JV; Gerasimenko, OV; Maruyama, Y; Petersen, OH; Tepikin, AV; Yano, K | 1 |
| Billington, RA; Conway, SJ; Genazzani, AA; Holmes, AB; Packman, L; Thuring, JW | 1 |
| Lee, HC; Li, PL; Meininger, GA; Nelson, MT; Van Breemen, C | 1 |
| Ashcroft, SJ; Churchill, GC; Galione, A; Masgrau, R; Morgan, AJ; Patel, S; Yamasaki, M | 1 |
| Carrey, EA; Churamani, D; Dickinson, GD; Patel, S | 1 |
| Berger, F; Ramírez-Hernández, MH; Ziegler, M | 1 |
| Krause, E; Schulz, I | 1 |
| Buxton, IL | 1 |
| Gerasimenko, J; Gerasimenko, O | 1 |
| Bak, J; Billington, RA; Debidda, M; Genazzani, AA; Martinez-Coscolla, A | 1 |
| Dowden, J; Galione, A; Parrington, J | 1 |
| Guse, AH; Langhorst, MF; Schwarzmann, N | 1 |
| Berridge, G; Brown, RS; Dowden, J; Galione, A; Moreau, C; Potter, BV | 1 |
| Lim, D; Moccia, F; Santella, L | 1 |
| Kyozuka, K; Lim, D; Moccia, F; Santella, L | 1 |
| Brailoiu, E; Brailoiu, GC; Dun, NJ; Dun, SL; Filipeanu, CM; Hoard, JL; Patel, S | 1 |
| Billington, RA; Genazzani, AA; Reichenbach, S; Sorba, G; Tron, GC | 1 |
| Epel, D; Kuo, RC; Patton, C; Preston, CM; Thaler, CD; Yagisawa, H | 1 |
| Churamani, D; Dickinson, GD; Patel, S | 1 |
| Dudzinska, W; Hlynczak, AJ | 1 |
| Dammermann, W; Guse, AH | 1 |
| Santella, L | 1 |
| Galione, A; Petersen, OH | 1 |
| Cancela, JM; Churchill, GC; Galione, A; Garnham, C; Lewis, AM; Patel, S; Thomas, JM; Yamasaki, M | 1 |
| Senior, K | 1 |
| Blanco, EA; Clark, JH; Evans, AM; Kinnear, NP; Wyatt, CN | 1 |
| Heidemann, AC; Kettenmann, H; Schipke, CG | 1 |
| López, JJ; Pariente, JA; Redondo, PC; Rosado, JA; Salido, GM | 1 |
| Goodrich, SP; Kellenberger, E; Kusser, K; LoVerde, PT; Lund, FE; Moutin, MJ; Muller-Steffner, H; Osman, A; Randall, TD; Roberts, A; Schuber, F; Woodland, DL | 1 |
| Churchill, GC; Galione, A; Yamasaki, M | 1 |
| Walseth, TF | 1 |
| Brown, RS; Dowden, J; Galione, A; Moreau, C; Potter, BV | 1 |
| Deitmer, JW; Singaravelu, K | 1 |
| Bak, J; Mándi, M; Timár, G; Tóth, B | 1 |
| Bellomo, EA; Billington, RA; Distasi, C; Erriquez, J; Floriddia, EM; Genazzani, AA | 1 |
| Gerasimenko, JV; Gerasimenko, OV; Petersen, OH; Sherwood, M; Tepikin, AV | 1 |
| Koeberl, MJ; Li, PL; Wallander, E; Zhang, AY; Zhang, F; Zhang, G | 1 |
| Kyozuka, K; Lim, D; Moccia, F; Nusco, GA; Santella, L | 1 |
| Churamani, D; Dickinson, GD; Patel, S; Ziegler, M | 1 |
| Bagley, LA; Beck, A; Fleig, A; Kolisek, M; Penner, R | 1 |
| Brailoiu, E; Brailoiu, GC; Churamani, D; Dun, NJ; Pandey, V; Patel, S; Tuluc, F | 1 |
| Bruhn, S; Gasser, A; Guse, AH | 1 |
| Bruzzone, S; De Flora, A; Melone, L; Moreschi, I; Zocchi, E | 1 |
| Chini, EN; Galione, A; Isbell, A; Lund, FE; Prakash, Y; Soares, S; Thompson, M; White, T; Yamasaki, M | 1 |
| Berridge, G; Churchill, GC; Dowden, J; Galione, A; Moreau, C; Potter, BV; Yamasaki, M | 1 |
| Graeff, R; Hao, Q; Kriksunov, IA; Lee, HC; Liu, Q | 1 |
| Chun, JT; Ercolano, E; Gragnaniello, G; Kyozuka, K; Lim, D; Nusco, GA; Santella, L | 1 |
| Billington, RA; Moccia, F; Santella, L | 1 |
| Palade, P | 1 |
| Burdakov, A; Cancela, JM; Charpentier, G; Menteyne, A; Petersen, OH | 1 |
| Galione, A | 4 |
| Flowerdew, SE; Gerasimenko, JV; Gerasimenko, OV; Petersen, OH; Sukhomlin, TK; Tepikin, AV; Voronina, SG | 1 |
| Galione, A; Morgan, AJ | 4 |
| Corkey, BE; Corkey, RF; Deeney, JT; Heart, E; Liu, L; Luc, E; Schultz, V; Shirihai, O; Smith, PJ; Tornheim, K; Yaney, GC | 1 |
| Fliegert, R; Gasser, A; Guse, AH | 1 |
| Berry, A; Churchill, GC; Dowden, J; Galione, A; Parkesh, R; Vasudevan, SR | 1 |
| Deguchi, R | 1 |
| Churchill, GC; Galione, A; Macgregor, A; Parkesh, R; Rakovic, S; Sanders, L; Terrar, DA; Yamasaki, M | 1 |
| Ohshima, T; Sakuraba, H; Yamaguchi, F | 1 |
| Guse, AH; Kirchberger, T; Steen, M | 1 |
| Li, PL; Zhang, F | 1 |
| Bodrato, N; Bruzzone, S; De Flora, A; Guida, L; Kassack, MU; Moreschi, I; Nicholas, RA; Usai, C; Zocchi, E | 1 |
| Boulware, MJ; Churamani, D; Dale, L; Geach, TJ; Marchant, JS; Martin, AC; Moy, GW; Patel, S; Su, YH; Vacquier, VD | 1 |
| Håkansson, K; Liu, H; Yoo, HJ | 1 |
| Churchill, GC; Galione, A; Garnham, C; James, K; Lewis, AM; Macdonald, A; Masgrau, R; O'Neill, JS; Vasudevan, SR; Yamasaki, M; Ziegler, M | 1 |
| Aley, PK; Arredouani, A; Churchill, GC; Dowden, J; Galione, A; Lewis, AM; Parkesh, R; Rosen, D; Rossi, S; Tavares, R; Vasudevan, SR | 1 |
| Im, MJ; Kim, BJ; Kim, UH; Okamoto, H; Park, KH; Takasawa, S; Yim, CY | 1 |
| Calcraft, PJ; Clark, JH; Evans, AM; Fleischer, S; Jeyakumar, LH; Kinnear, NP; Nixon, GF; Wyatt, CN | 1 |
| Churchill, GC; Galione, A; Vasudevan, SR | 1 |
| Billington, RA; D'Alessio, A; Debidda, M; Filippini, A; Gambara, G; Genazzani, AA; Palombi, F; Ziparo, E | 1 |
| Bellomo, EA; Rutter, GA | 1 |
| Bak, J; Mándi, M | 1 |
| Beck, A; Fleig, A; Lange, I; Penner, R | 1 |
| Baux, G; Bezin, S; Cancela, JM; Charpentier, G; Fossier, P; Lee, HC | 1 |
| Jin, S; Li, PL; Yi, F; Zhang, F | 1 |
| Boulware, MJ; Churamani, D; Dale, L; Geach, TJ; Marchant, JS; Martin, AC; Patel, S; Ramakrishnan, L; Vacquier, VD | 1 |
| Guse, AH; Lee, HC | 1 |
| Brailoiu, E; Brailoiu, GC; Churchill, GC; Dun, NJ; Galione, A; Parkesh, R; Patel, S | 1 |
| Arredouani, A; Churchill, GC; Galione, A; Ganesan, A; Izumi, M; Lewis, AM; Mizote, A; Naylor, E; Parkesh, R; Rosen, D; Thomas, JM; Vasudevan, SR | 1 |
| Arredouani, A; Calcraft, PJ; Cheng, X; Chuang, KT; Evans, AM; Galione, A; Hao, X; Lin, P; Lin, Y; Ma, J; Pan, Z; Parrington, J; Rietdorf, K; Ruas, M; Tang, J; Teboul, L; Wang, C; Wyatt, CN; Xiao, R; Zhu, MX; Zhu, Y | 1 |
| Arendshorst, WJ; Churchill, GC; Thai, TL | 1 |
| Arredouani, A; Cheng, X; Evans, AM; Galione, A; Ma, J; Parrington, J; Zhu, MX | 1 |
| Cordiglieri, C; Dammermann, W; Dornmair, K; Dowden, J; Flügel, A; Guse, AH; Hohenegger, M; Kawakami, N; Kirchberger, T; Nebel, M; Odoardi, F; Potter, BV; Schmid, F; Zhang, B | 1 |
| Aley, PK; Brailoiu, E; Chuang, CC; Churchill, GC; Dun, NJ; Lewis, AM; Pandey, V; Patel, S | 1 |
| Biel, M; Cuny, H; Fenske, S; Griesbeck, O; Gruner, C; Harz, H; Rötzer, K; Schieder, M; Wahl-Schott, C; Zong, X | 1 |
| Boulware, MJ; Brailoiu, E; Brailoiu, GC; Cai, X; Churamani, D; Dun, NJ; Gao, X; Hooper, R; Marchant, JS; Patel, S; Schrlau, MG | 1 |
| Chen, ST; Chen, TJ; Hwang, GS; Wang, SW | 1 |
| Aley, PK; Churchill, GC; Galione, A; Ganesan, A; Izumi, M; Lewis, AM; Mizote, A; Parkesh, R; Rosen, D; Thomas, JM; Vasudevan, SR | 1 |
| Cho, BH; Kim, SY; Kim, UH | 1 |
| Brailoiu, E; Brailoiu, GC; Cai, X; Dun, NJ; Hooper, R; Keebler, MV; Marchant, JS; Patel, S | 1 |
| Calcraft, PJ; Evans, AM; Galione, A; Ma, J; Parrington, J; Zhu, MX | 1 |
| Evans, AM; Galione, A; Ma, J; Parrington, J; Zhu, MX | 1 |
| Li, PL; Xia, M; Zhang, F | 1 |
| Evans, AM | 1 |
| Brailoiu, E; Churchill, GC; Dickinson, GD; Patel, S | 1 |
| Aley, PK; Brailoiu, E; Churchill, GC; Gao, X; Noh, HJ; Tica, AA | 1 |
| Arredouani, A; Cheng, X; Churchill, GC; Davis, LC; Funnell, TM; Galione, A; Koegel, H; Lloyd-Evans, E; Morgan, AJ; Parrington, J; Platt, FM; Rietdorf, K; Ruas, M; Ward, JA; Watanabe, K; Wessel, GM; Zhu, MX | 1 |
| Bosc, C; Dale, L; Moutin, MJ; Muller-Steffner, H; Patel, S; Ramakrishnan, L; Schuber, F; Vacquier, VD | 1 |
| Chan, JW; Churchill, GC; Galione, A; Lewis, AM; Machin, CL; Sinha, D; Vasudevan, SR | 1 |
| Kim, SH; Kim, UH; Mushtaq, M; Nam, TS; Rah, SY | 1 |
| Cai, X; Patel, S | 1 |
| De Souza, W; Docampo, R; Lin, FY; Machado, EA; Miranda, K; Oldfield, E; Pace, DA; Ramos, IB; Verbist, KC; Zhang, Y | 1 |
| Breunig, E; Cordiglieri, C; Dammermann, W; Dornmair, K; Flügel, A; Guse, AH; Kawakami, N; Klinkert, WE; Lodygin, D; Lühder, F; Nebel, M; Odoardi, F; Potter, BV; Schild, D; Ulaganathan, VK; Zhang, B | 1 |
| Brading, A; Chuang, KT; Galione, A; Parrington, J; Ruas, M; Tugba Durlu-Kandilci, N | 1 |
| Brailoiu, E; Marchant, JS; Patel, S | 1 |
| Csanády, L; Tóth, B | 1 |
| Brailoiu, E; Dun, NJ; Friedman, G; Gogotsi, Y; Orynbayeva, Z; Vitol, EA | 1 |
| Churchill, GC; Funnell, TM; Galione, A; Ganesan, A; Gosain, R; Parrington, J; Pitt, SJ; Rietdorf, K; Ruas, M; Sitsapesan, M; Sitsapesan, R; Venturi, E; Zhu, MX | 1 |
| Cancela, JM; Cheviron, N; Cosker, F; Galione, A; Lund, FE; Menteyne, A; Moutin, MJ; Yamasaki, M | 1 |
| Brailoiu, E; Brailoiu, GC; Churamani, D; Hooper, R; Patel, S; Prole, DL; Rahman, T; Taylor, CW | 1 |
| Jain, P; Perez-Haddock, LA; Slama, JT; Walseth, TF | 1 |
| Aviram, M; Rosenblat, M; Volkova, N | 1 |
| Aley, PK; Berger, F; Churchill, GC; Galione, A; Mikolajczyk, AM; Munz, B | 1 |
| Arredouani, A; Davis, LC; Galione, A; Morgan, AJ; Parrington, J; Rietdorf, K; Ruas, M | 1 |
| Lloyd-Evans, E; Peterneva, K; Platt, FM; Waller-Evans, H | 1 |
| Harper, AG; Mason, MJ; Pugh, N; Sage, SO | 1 |
| Brailoiu, E; Churamani, D; Hooper, R; Patel, S; Taylor, CW | 1 |
| Galfré, E; Pitt, S; Sitsapesan, R; Venturi, E | 1 |
| Evans, AM; Ma, J; Ogunbayo, OA; Rossi, D; Sorrentino, V; Zhu, MX; Zhu, Y | 1 |
| Morgan, AJ | 1 |
| Kim, UH; Mushtaq, M; Nam, TS | 1 |
| Churchill, GC; D'Alessio, A; Esposito, B; Filippini, A; Galione, A; Gambara, G; Genazzani, AA; Lewis, AM; Palombi, F; Taylor, LX; Ziparo, E | 1 |
| Peiter, E | 1 |
| Gerasimenko, JV; Gerasimenko, OV; Petersen, OH; Tepikin, AV | 1 |
| Brailoiu, E; Hamdoun, A; Marchant, JS; Patel, S; Rahman, T; Ramakrishnan, L; Taylor, CW | 1 |
| Brailoiu, E; Churamani, D; Dickinson, GD; Jha, A; Li, Q; Muallem, S; Patel, S; Soyombo, AA; Yamaguchi, S | 1 |
| Albarrán, L; Berna-Erro, A; Bobe, R; Dionisio, N; López, JJ; Rosado, JA; Salido, GM | 1 |
| Bincoletto, C; Bloor-Young, D; Churchill, G; do Carmo, LG; Fimia, GM; Han, SW; Hirata, H; Patel, S; Pereira, GJ; Piacentini, M; Smaili, SS; Stilhano, RS; Ureshino, RP | 1 |
| Han, WQ; Li, PL; Xu, M; Zhang, F | 1 |
| Brailoiu, E; Brailoiu, GC; Deliu, E; Motoc, D; Tica, AA | 1 |
| Barceló-Torns, M; Barneda, D; Bloor-Young, D; Churchill, GC; Claro, E; Gubern, A; Lewis, AM; Masgrau, R; Picatoste, F | 1 |
| Lloyd-Evans, E; Platt, FM | 1 |
| Funnell, T; Galione, A; Parrington, J | 1 |
| Dale, P; Taylor, CW | 1 |
| Funnell, TM; Galione, A; Heinemann, J; Parrington, J; Rietdorf, K; Ruas, M | 1 |
| Bayliss, R; Churchill, GC; Collins, TP; Galione, A; Terrar, DA | 1 |
| Keebler, MV; Konieczny, V; Taylor, CW | 1 |
| Campbell, RD; Churchill, GC; Coxon, CH; Dundas, KA; Gibbins, JM; Lewis, AM; Sadler, AJ; Taylor, L; Thomas, A; Tucker, KL; Vasudevan, SR | 1 |
| Brailoiu, E; Churamani, D; Hooper, R; Patel, S | 1 |
| Bloor-Young, D; Churamani, D; Churchill, GC; Gómez-Suaga, P; Hilfiker, S; Luzón-Toro, B; Patel, S; Woodman, PG; Zhang, L | 1 |
| Bruhn, S; Guse, AH; Mittrücker, HW; Schmid, F; Weber, K | 1 |
| Brailoiu, E; Churamani, D; Davidson, SM; Hooper, R; Lin-Moshier, Y; Marchant, JS; Patel, S; Slama, JT; Walseth, TF | 1 |
| Galione, A; Jain, P; Lin-Moshier, Y; Marchant, JS; Parrington, J; Ruas, M; Slama, JT; Walseth, TF | 1 |
| Lee, AK; Tse, A; Yeung-Yam-Wah, V | 1 |
| Brailoiu, E; Patel, S | 2 |
| Gómez-Suaga, P; Hilfiker, S | 1 |
| Chuang, KT; Galione, A | 1 |
| Hooper, R; Patel, S | 1 |
| Ahuja, M; Churamani, D; Coblentz, J; Kiselyov, K; Muallem, S; Patel, S; Rybalchenko, V | 1 |
| Graeff, R; Lee, HC; Zhao, Y | 1 |
| Bauche, A; Fliegert, R; Guse, AH; Schmid, F; Westphal, T | 1 |
| Chun, JT; Santella, L; Vasilev, F | 1 |
| Churchill, GC; Gómez-Suaga, P; Hilfiker, S; Patel, S | 1 |
| Aley, PK; Bloor-Young, D; Churchill, GC; Galione, A; Garnham, C; Lewis, AM; Masgrau, R; Paramore, C; Roomi, A; Sanders, LE; Shipman, K; Terrar, DA; Thomas, JM | 1 |
| Cheng, X; Clapham, DE; Dong, XP; Goschka, A; Harlow, J; Li, X; Ren, D; Samie, M; Shen, D; Wang, X; Xu, H; Zhang, X; Zhou, Y; Zhu, MX | 1 |
| Galione, A; Morgan, AJ; Parrington, J | 1 |
| Bloor-Young, D; Cerundolo, V; Chen, JL; Churchill, GC; Conway, SJ; Davis, LC; Galione, A; Morgan, AJ; Parrington, J; Shenderov, E; Snead, CM; Stanton-Humphreys, MN | 1 |
| Han, MK; Kang, HS; Kim, HK; Kim, JS; Kim, UH; Kim, YR; Lee, YR; Park, HM; Song, EK; Yeom, JH; Yoo, CH | 1 |
| Mao, XW; Pan, CS; Shao, SY | 1 |
| Ramos, I; Wessel, GM | 1 |
| Barski, OA; Bhatnagar, A; Kilfoil, PJ; Tipparaju, SM | 1 |
| Jiang, YL; Lee, S; Lin, AH; Paudel, O; Ran, P; Sham, JS; Sun, H; Xia, Y; Yang, XR | 1 |
| Aley, PK; Brailoiu, E; Brailoiu, GC; Churchill, GC; Singh, N | 1 |
| Churchill, GC; Davis, LC; Galione, A; Lewis, AM; Morgan, AJ; Parrington, J; Wagner, SK | 1 |
| Wu, H | 1 |
| Bruhn, S; Carrier, L; Ehmke, H; Eschenhagen, T; Fliegert, R; Geisler, A; Guse, AH; Herich, L; Hohenegger, M; Limbrock, AC; Nebel, M; Potter, BV; Schlegel, S; Schwoerer, AP; Siebrands, CC; Swarbrick, JM; Warszta, D; Weber, K | 1 |
| Djerada, Z; Dukic, S; Millart, H; Peyret, H | 1 |
| Brailoiu, E; Churamani, D; Hooper, R; Patel, S; Rahman, T | 1 |
| Djerada, Z; Millart, H | 1 |
| Lu, YY; Yue, J; Zhang, ZH | 1 |
| Graeff, R; Hao, BX; Lu, Y; Wong, CW; Wu, WT; Yue, J | 1 |
| Gulbins, E; Li, PL; Li, XX; Xia, M; Xiong, J; Xu, M; Zhang, Y | 1 |
| Han, MK; Kim, BJ; Kim, UH; Lee, HC; Park, KH; Shawl, AI | 1 |
| Ernst, IM; Fliegert, R; Guse, AH | 1 |
| Abais, JM; Boini, KM; Li, G; Li, PL; Riebling, CR; Ritter, JK; Xia, M; Xiong, J; Xu, M; Zhang, Y | 1 |
| Churchill, GC; Nishigaki, T; Sánchez-Tusie, AA; Treviño, CL; Vasudevan, SR | 1 |
| Ali, RA; Giovannucci, DR; Slama, JT; Trabbic, CJ; Wall, KA; Walseth, TF; Zhelay, T | 1 |
| Brunco, A; Massarotti, A; Sorba, G; Tron, GC | 1 |
| Arlt, E; Arndt, L; Biel, M; Boekhoff, I; Borth, H; Breit, A; Castonguay, J; Gudermann, T; Hassan, S; Klugbauer, N; Meyer, D; Wahl-Schott, C; Wennemuth, G; Zierler, S | 1 |
| Ahuja, M; Brailoiu, E; Jha, A; Muallem, S; Patel, S | 1 |
| Parrington, J; Tunn, R | 1 |
| Han, JM; Kilpatrick, BS; Patel, S; Penny, CJ; Sneyd, J | 1 |
| Brailoiu, E; Jha, A; Muallem, S | 1 |
| Iwata, H; Kanoh, Y; Ohshima, T; Sakuraba, H; Uehara, S; Yoneda, K | 1 |
| Galione, A; Lam, AK; Pitt, SJ; Rietdorf, K; Sitsapesan, R | 1 |
| Bincoletto, C; Churchill, G; do Carmo, LG; Han, SW; Hirata, H; Medaglia, NC; Patel, S; Pereira, GJ; Smaili, SS; Stilhano, RS; Ureshino, RP | 1 |
| Jiang, Y; Lee, S; Paudel, O; Sham, JS; Yang, XR | 1 |
| Abood, ME; Boulware, MJ; Brailoiu, E; Churamani, D; Hooper, R; Keebler, MV; Lin-Moshier, Y; Liu, X; Marchant, JS; Patel, S; Walseth, TF | 1 |
| Gallegos-Gomez, ML; Guerrero-Hernandez, A; Lopez-Mendez, MC; Sanchez-Vazquez, VH | 1 |
| Chuang, KT; Churchill, GC; Davis, LC; Funnell, TM; Galione, A; Morgan, AJ; Parrington, J; Ruas, M | 5 |
| D'Alessio, A; Del Bufalo, D; Desideri, M; Esposito, B; Favia, A; Filippini, A; Galione, A; Gambara, G; Palombi, F; Parrington, J; Ruas, M; Ziparo, E | 1 |
| López Sanjurjo, CI; Taylor, CW; Tovey, SC | 1 |
| Ramos, I; Reich, A; Wessel, GM | 1 |
| Abood, ME; Brailoiu, E; Brailoiu, GC; Cai, X; Patel, S; Rahman, T | 1 |
| Brailoiu, E; Brailoiu, GC; Eden, ER; Futter, CE; Hockey, LN; Kilpatrick, BS; Lin-Moshier, Y; Marchant, JS; Patel, S; Schapira, AH | 1 |
| Athanasou, NA; Cheng, X; Galione, A; Hookway, ES; Kashima, T; Oppermann, U | 1 |
| Lee, HC; Wang, XW; Zhang, LH; Zhao, YJ; Zhu, WJ | 1 |
| Agbani, E; Evans, AM; Li, J; Ma, J; Ogunbayo, OA; Shen, B; Zhu, MX; Zhu, Y | 1 |
| Denti, F; Gagliano, G; Genazzani, AA; Guerra, G; Lim, D; Mapelli, L; Moccia, F; Pinton, P; Potenza, DM; Ronco, V; Tognolina, M; Vullo, S | 1 |
| Jang, KY; Kim, KN; Kim, UH; Park, DR; Park, KH | 1 |
| Bauta, WE; Biel, M; Chen, CC; Davey, RA; Grimm, C; Klugbauer, N; Kolokoltsov, AA; Sakurai, Y; Tidwell, MW; Wahl-Schott, C | 1 |
| Slama, JT; Trabbic, CJ; Walseth, TF; Zhang, F | 1 |
| Molinari, G | 1 |
| Biel, M; Chen, CC; Chuang, KT; Davis, LC; Galione, A; Garnham, C; Grimm, C; Morgan, AJ; Parrington, J; Platt, FM; Platt, N; Powell, T; Ruas, M; Wahl-Schott, C; Walseth, TF | 1 |
| Csanády, L; Iordanov, I; Tóth, B | 1 |
| Davis, LC; Galione, A; Morgan, AJ; Ruas, M | 1 |
| Mills, SJ; Potter, BV; Riley, AM; Swarbrick, JM | 1 |
| Marchant, JS; Patel, S | 1 |
| Charlesworth, RM; Ferdek, PE; Gerasimenko, JV; Gerasimenko, OV; Mikoshiba, K; Parrington, J; Petersen, OH; Sherwood, MW | 1 |
| Arredouani, A; Bellomo, EA; Braun, M; Chuang, KT; Churchill, GC; Clough, F; Collins, SC; Coltart, G; Gadea, J; Galione, A; Heister, PM; Johnson, P; Lewis, AM; Morgan, AJ; Parkesh, R; Parrington, J; Pillinger, T; Rietdorf, K; Rorsman, P; Royle, A; Ruas, M; Rutter, GA; Shimomura, K; Sones, W; Teboul, L; Tunn, R; Tynan, PW; Zhang, Q | 1 |
| Ha, TG; Kim, SY; Kim, UH; Park, DR; Park, KH; Shawl, AI | 1 |
| Davidson, SM; Duchen, MR; Foote, K; Ganesan, A; Gosain, R; Graeff, R; Kunuthur, S; Patel, S; Tan, N; Tyser, R; Yellon, DM; Zhao, YJ | 1 |
| Aston, D; Bloor-Young, D; Bolton, EL; Burton, RA; Capel, RA; Churchill, GC; Galione, A; Lei, M; Lin, WK; Liu, W; Parrington, J; Ruas, M; Shade, KT; Terrar, DA; Wang, X; Wang, Y | 1 |
| Czarniak, F; Diercks, BP; Fliegert, R; Flügel, A; Gattkowski, E; Guse, AH; Kempski, J; Lodygin, D; Mittrücker, HW; Schetelig, D; Schumacher, V; von Osten, M; Werner, R; Wolf, IM | 1 |
| Hachem, A; Lear, P; Parrington, J | 1 |
| Ali, RA; Bhattacharya, S; Camick, C; Giovannucci, DR; Slama, JT; Wall, KA; Walseth, TF; Wiles, K | 1 |
| Del Bufalo, D; Desideri, M; Favia, A; Filippini, A; Montesano, C; Nicoletti, C; Orlandi, A; Padula, F; Pafumi, I; Palombi, F; Passeri, D; Sergi, M; Ziparo, E | 1 |
| Cao, Y; Chang, G; Gu, X; Nie, A; Yang, R; Zhang, H | 1 |
| Guse, AH; Wolf, IM | 1 |
| Dewey, WL; Li, N; Li, PL; Xu, X; Yuan, X; Zhang, F | 1 |
| Cheng, CW; Cheung, KH; Hung, HC; Lee, CS; Tong, BC | 1 |
| Pitt, SJ; Reilly-O'Donnell, B; Sitsapesan, R | 1 |
| Gul, R; Im, SY; Jang, KY; Kim, D; Kim, UH; Ko, JK; Lee, SH; Nam, TS; Park, DR; Shawl, AI | 1 |
| Patel, S; Penny, CJ; Rahman, T | 1 |
| Brailoiu, E; Brailoiu, GC | 1 |
| Babiker, F; Khalaf, A | 1 |
| Churchill, GC; Fdez, E; Fernández, B; Ferrer, I; Gil, F; Gómez-Suaga, P; Hilfiker, S; Molina-Villalba, I; Patel, S | 1 |
| Cheong, JH; Hwang, GS; Hwang, TH; Kee, HJ; Lee, J; Min, S; Park, KC; Park, S; Ryu, DH | 1 |
| Feijóo-Bandín, S; García-Rúa, V; García-Vence, M; González-Juanatey, JR; Lago, F; Portolés, M; Rivera, M; Roselló-Lletí, E | 1 |
| Bhattacharya, S; Giovannucci, DR; Goswamee, P; Imbery, JF; Iqbal, AK; Khuder, S; Weiss, A | 1 |
| Brieke, C; Edelmann, D; Meinhart, A; Rocker, A; Schessner, J; Schuebel, F | 1 |
| Kyozuka, K; Takahashi, I | 1 |
| Chini, CCS; Chini, EN; Tarragó, MG | 1 |
| Antonioli, M; Bincoletto, C; Fimia, GM; Hirata, H; Nascimento, AR; Pereira, GJ; Piacentini, M; Smaili, SS; Ureshino, RP; Vescovo, T | 1 |
| Aston, D; Burton, RA; Capel, RA; Christian, HC; Ford, KL; Galione, A; Kohl, P; Mirams, GR; Rog-Zielinska, EA; Terrar, DA | 1 |
| Atzberger, C; Bartel, K; Biel, M; Chao, YK; Grimm, C; Mayr, D; Nguyen, ON; Schneider, LS; Ulrich, M; Vollmar, AM; Wahl-Schott, C; Watermann, A | 1 |
| Akther, S; Al Mahmuda, N; Fakhrul, A; Gerasimenko, M; Higashida, H; Ishihara, K; Kasai, S; Kim, UH; Liang, M; Lopatina, O; Nam, TS; Nishimura, T; Salmina, A; Stanislav, C; Tsuji, C; Tsuji, T; Yokoyama, S; Yoshihara, T; Zhong, J | 1 |
| Ambrosone, L; De Luca, A; Di Nezza, F; Guerra, G; Moccia, F; Poletto, V; Rosti, V; Zuccolo, E | 1 |
| Carpaneto, A; Cornara, L; Favia, A; Festa, M; Filippini, A; Gambale, F; Giunta, C; Gutla, V; Lagostena, L; Pafumi, I; Palombi, F; Papacci, F | 1 |
| Alano, P; Favia, A; Filippini, A; Gambara, G; Palombi, F; Suárez-Cortés, P | 1 |
| Brailoiu, E; Churamani, D; Patel, S | 1 |
| Chen, YJ; Deng, QW; Fang, C; Hou, YN; Lee, HC; Li, T; Li, Y; Xu, GJ; Zhao, YJ | 1 |
| Duan, J; Evans, AM; Feng, X; Ma, J; Ogunbayo, OA; Wang, Q; Xiong, J; Zhu, MX | 1 |
| Glitsch, MD | 1 |
| Gunaratne, GS; Li, F; Marchant, JS; Walseth, TF; Yang, Y | 1 |
| Gunaratne, GS; Hintz, HM; Johns, ME; Marchant, JS; Walseth, TF | 1 |
| Baldan, B; Barbulova, A; Chiurazzi, M; Cortese, E; Lorito, M; Mariani, P; Moscatiello, R; Navazio, L; Nigris, S; Ruocco, M; Sello, S | 1 |
| Emptage, NJ; Foster, WJ; Galione, A; Jeans, AF; Padamsey, Z; Taylor, HBC | 1 |
| Gunaratne, GS; Marchant, JS; Slama, JT; Su, P; Walseth, TF | 1 |
| Desai, T; Giovannucci, DR; Imbery, JF; Iqbal, AK | 1 |
| Gunaratne, GS; Marchant, JS; Patel, S; Yuan, Y | 1 |
| Asfaha, TY; Gunaratne, GS; Johns, ME; Marchant, JS; Slama, JT; Walseth, TF | 1 |
| Lee, HC; Zhao, YJ | 1 |
| Biel, M; Bracher, F; Burgstaller, S; Chao, YK; Chen, CC; Gerndt, S; Grimm, C; Gudermann, T; Jacob, K; Keller, M; Krogsaeter, E; Malli, R; Miller, MT; Nguyen, ONP; Patel, S; Schaefer, M; Schredelseker, J; Scotto Rosato, A; Urban, N; Vollmar, AM; Wahl-Schott, C; Yuan, Y; Zierler, S | 1 |
| Davis, LC; Galione, A; Morgan, AJ | 1 |
| Ambrosone, L; De Luca, A; Di Nezza, F; Faris, PS; Guerra, G; Laforenza, U; Moccia, F; Negri, S; Pellavio, G; Rosti, V; Zuccolo, E | 1 |
| Brenner, C; Chung, HT; Kim, UH; Nam, TS; Park, DR; Rah, SY; Woo, TG | 1 |
| Freeman, SA; Grinstein, S; Westman, J | 1 |
| Ju, HQ; Lin, JF; Tian, T; Xie, D; Xu, RH | 1 |
| Gao, W; Huang, C; Huber, PE; Li, C; Shen, G; Xie, N; Zhang, L; Zhou, X; Zou, B | 1 |
| Bretz, JD; Gunaratne, GS; Marchant, JS; Slama, JT; Su, P; Walseth, TF | 1 |
| Gregori, M; Patel, S; Yuan, Y | 1 |
| Brailoiu, E; Gunaratne, GS; He, S; Marchant, JS; Patel, S; Slama, JT; Unterwald, EM; Walseth, TF | 1 |
| Becker, SM; Honwad, HH; Irazoqui, JE; Moreau, JA; Najibi, M | 1 |
| Galione, A; Heister, PM; Powell, T | 1 |
| Ganesan, S; Heijjer, CN; Hwang, IY; Karlsson, MCI; Kehrl, JH; Nabar, NR; Shi, CS | 1 |
| Guan, X; Shah, K; Yan, J; Zhang, J | 1 |
| Biggin, PC; Gunaratne, GS; Marchant, JS; Patel, S; Rahman, T | 1 |
| Alpers, R; Bauche, A; Bowie, AG; Carty, M; Diercks, BP; Flügel, A; Grasberger, H; Gu, F; Guse, AH; Heeren, J; Hernandez C, LC; Huber, S; Jaquet, V; Kao, JY; Krause, KH; Krüger, A; Lodygin, D; Meier, C; Mittrücker, HW; Möckl, F; Roggenkamp, HG; Rosche, A; Schetelig, D; Schröder, K; Werner, R; Winterberg, K | 1 |
| Cai, X; Gunaratne, GS; Marchant, JS; Patel, S; Slama, JT | 1 |
| Bedke, T; Diercks, BP; Gagliani, N; Guse, AH; Huber, S; Lory, N; Meier, C; Mittrücker, HW; Nawrocki, M; Stumme, F | 1 |
| Gunaratne, GS; Marchant, JS; Patel, S; Rahman, T; Yuan, Y | 1 |
| Kim, UH | 1 |
| Guan, X; Shah, KR; Yan, J | 1 |
| Chen, L; He, X; Kang, Y | 1 |
| Wang, Q; Zhu, MX | 1 |
| Ferro, IF; Grimm, C; Jaślan, D; Kudrina, V; Patel, S; Yuan, Y | 1 |
| Antonioli, M; Bincoletto, C; Erustes, AG; Fimia, GM; Medaglia, NC; Pereira, CAS; Pereira, GJDS; Piacentini, M; Smaili, SS; Ureshino, RP | 1 |
| Anjum, I; Denizalti, M; Durlu-Kandilci, NT; Sahin-Erdemli, I | 1 |
| Heßling, LD; Troost-Kind, B; Weiß, M | 1 |
| Brailoiu, E; Gunaratne, GS; Kumar, S; Marchant, JS; Patel, S; Slama, JT; Walseth, TF; Yuan, Y | 1 |
94 review(s) available for naadp and nadp
| Article | Year |
|---|---|
Adenine nucleotide diphosphates: emerging second messengers acting via intracellular Ca2+ release.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Calcium Channels; Cell Compartmentation; Cyclic ADP-Ribose; Homeostasis; Muscle Proteins; NADP; Ryanodine Receptor Calcium Release Channel; Sea Urchins; Second Messenger Systems; Signal Transduction; Tretinoin | 1996 |
A Ca2+ release mechanism gated by the novel pyridine nucleotide, NAADP.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Calcium; Dose-Response Relationship, Drug; Ion Channel Gating; Membrane Glycoproteins; N-Glycosyl Hydrolases; NADP; Oocytes; Phosphatidylinositols; Rats; Sea Urchins; Signal Transduction; Tissue Distribution; Xenopus laevis | 1997 |
Mechanisms of calcium signaling by cyclic ADP-ribose and NAADP.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Amino Acid Sequence; Animals; Antigens, CD; Antigens, Differentiation; Calcium; Calmodulin; Cyclic ADP-Ribose; HL-60 Cells; Humans; Membrane Glycoproteins; Molecular Sequence Data; NAD+ Nucleosidase; NADP; Nitric Oxide; PC12 Cells; Rats; Sea Urchins; Signal Transduction; Tretinoin | 1997 |
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Antigens, CD; Antigens, Differentiation; Calcium; Catalysis; Dose-Response Relationship, Drug; Models, Chemical; Models, Genetic; Models, Molecular; NAD+ Nucleosidase; NADP; Sequence Homology, Amino Acid; Structure-Activity Relationship; Time Factors | 1999 |
NAADP: An emerging calcium signaling molecule.
Topics: Animals; Calcium; Invertebrates; Mammals; NADP; Signal Transduction | 2000 |
Enzymatic functions and structures of CD38 and homologs.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Amino Acid Sequence; Animals; Antigens, CD; Antigens, Differentiation; Calcium; Catalysis; Cyclic ADP-Ribose; Dimerization; Humans; Membrane Glycoproteins; Molecular Sequence Data; Multienzyme Complexes; NAD+ Nucleosidase; NADP; Protein Structure, Secondary | 2000 |
NAADP-induced calcium release in sea urchin eggs.
Topics: Animals; Calcium; Calcium Signaling; Fertilization; NADP; Ovum; Sea Urchins | 2000 |
Intracellular Ca(2+) release mechanisms: multiple pathways having multiple functions within the same cell type?
Topics: Adenosine Diphosphate Ribose; Animals; Biological Evolution; Calcium; Cell Line; Cyclic ADP-Ribose; Humans; Inositol 1,4,5-Trisphosphate; NADP; Second Messenger Systems; Signal Transduction | 2000 |
Specific Ca2+ signaling evoked by cholecystokinin and acetylcholine: the roles of NAADP, cADPR, and IP3.
Topics: Acetylcholine; Adenosine Diphosphate Ribose; Animals; Calcium Signaling; Cholecystokinin; Cyclic ADP-Ribose; Humans; Inositol 1,4,5-Trisphosphate; NADP | 2001 |
Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Calcium Signaling; Humans; NADP | 2001 |
Neutrophil oscillations: temporal and spatiotemporal aspects of cell behavior.
Topics: Biological Clocks; Calcium; Humans; Hydrogen-Ion Concentration; NADP; Neutrophils; Signal Transduction | 2001 |
Coordination of Ca2+ signalling by NAADP.
Topics: Calcium Signaling; NADP | 2001 |
Calcium channels in lymphocytes.
Topics: Calcium Channels; Humans; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Lymphocyte Subsets; NADP; Receptors, Cytoplasmic and Nuclear; Receptors, Immunologic; Ryanodine Receptor Calcium Release Channel | 2001 |
Multiple calcium stores: separate but interacting.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Calcium Signaling; Cyclic ADP-Ribose; Humans; Inositol Phosphates; NADP | 2000 |
NAADP: an atypical Ca2+-release messenger?
Topics: Animals; Calcium; Calcium Signaling; Humans; NADP; Ryanodine Receptor Calcium Release Channel; Second Messenger Systems | 2002 |
Nicotinic acid adenine dinucleotide phosphate: a new intracellular second messenger?
Topics: Animals; Calcium; Humans; Intracellular Fluid; NADP; Ovum; Plants; Sea Urchins; Second Messenger Systems | 2002 |
[Electron transfer flavoprotein in mitochondria].
Topics: Animals; Electron Transport; Electron-Transferring Flavoproteins; Fatty Acids; Flavins; Flavoproteins; Glutarates; Humans; Mitochondria; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Protein Conformation | 2002 |
Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP): novel regulators of Ca2+-signaling and cell function.
Topics: Animals; Calcium; Calcium Signaling; Cell Nucleus; Cyclic ADP-Ribose; Humans; Islets of Langerhans; Muscle, Smooth; Myocytes, Cardiac; NADP; Neurons; T-Lymphocytes | 2002 |
Co-ordination of Ca(2+) signalling in mammalian cells by the new Ca(2+)-releasing messenger NAADP.
Topics: Animals; Calcium; Calcium Signaling; Cell Physiological Phenomena; NADP; Second Messenger Systems | 2003 |
Calcium signalling: NAADP comes out of the shadows.
Topics: Animals; B-Lymphocytes; Calcium Signaling; Humans; Lymphocyte Activation; NADP; Second Messenger Systems; T-Lymphocytes | 2003 |
The new life of a centenarian: signalling functions of NAD(P).
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Eukaryotic Cells; Humans; Life Expectancy; Models, Biological; Molecular Structure; NAD; NADP; Signal Transduction | 2004 |
NAADP-induced Ca2+ release -- a new signalling pathway.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Humans; NADP; Receptor Cross-Talk | 2004 |
Multiplicity of Ca2+ messengers and Ca2+ stores: a perspective from cyclic ADP-ribose and NAADP.
Topics: Animals; Calcium; Catalysis; Cyclic ADP-Ribose; Humans; NADP | 2004 |
Inositol 1,4,5-trisphosphate and its co-players in the concert of Ca2+ signalling--new faces in the line up.
Topics: Calcium Signaling; Cyclic ADP-Ribose; Inositol 1,4,5-Trisphosphate; NADP | 2004 |
Regulation of uterine function: a biochemical conundrum in the regulation of smooth muscle relaxation.
Topics: Calcium; Cyclic GMP; Female; Humans; Muscle, Smooth; Myometrium; NADP; Nitric Oxide; Potassium Channels; Tocolytic Agents | 2004 |
New aspects of nuclear calcium signalling.
Topics: Animals; Calcium; Cell Nucleus; Cyclic ADP-Ribose; Endoplasmic Reticulum; Humans; Inositol 1,4,5-Trisphosphate; Lysosomes; Models, Biological; NADP; Pancreas; Ryanodine Receptor Calcium Release Channel; Signal Transduction; Thapsigargin | 2004 |
The NAADP receptor: commentary on Billington et al.
Topics: Animals; Humans; NADP; Receptors, Cell Surface; Structure-Activity Relationship | 2004 |
Calcium and fertilization: the beginning of life.
Topics: Animals; Calcium; Calcium Signaling; Fertilization; Humans; Inositol 1,4,5-Trisphosphate; NADP | 2004 |
NAADP: a new second messenger comes of age.
Topics: Animals; Calcium; Humans; Hydrogen-Ion Concentration; NADP; Oocytes; Oscillometry; Second Messenger Systems; Signal Transduction; Starfish; Time Factors | 2005 |
The NAADP receptor: new receptors or new regulation?
Topics: Animals; Calcium; Calcium Signaling; Cyclic AMP; Cyclic GMP; Gene Expression Regulation; Humans; Inositol Phosphates; Models, Biological; NADP; Niacin; Receptors, Nicotinic; Ryanodine Receptor Calcium Release Channel; Sea Urchins; Signal Transduction | 2005 |
Pyridine nucleotides and calcium signalling in arterial smooth muscle: from cell physiology to pharmacology.
Topics: Calcium Signaling; Cyclic ADP-Ribose; Humans; Muscle, Smooth, Vascular; NADP; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Vasoconstriction; Vasodilation | 2005 |
Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling.
Topics: Animals; Calcium; Calcium Signaling; NADP; Sea Urchins | 2005 |
Calcium signalling by nicotinic acid adenine dinucleotide phosphate (NAADP).
Topics: Animals; Calcium; Calcium Signaling; Cyclic ADP-Ribose; Humans; Inositol 1,4,5-Trisphosphate; NADP; Second Messenger Systems | 2005 |
The hunt for an alternate way to generate NAADP. Focus on "NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells".
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Female; Humans; Myometrium; NADP; Second Messenger Systems | 2007 |
Regulation of calcium signalling by adenine-based second messengers.
Topics: Adenine; Animals; Calcium; Calcium Signaling; Cyclic ADP-Ribose; Humans; Models, Biological; Models, Chemical; NADP; Receptors, Purinergic P2; Second Messenger Systems; Signal Transduction; TRPM Cation Channels | 2007 |
Ca2+ signalling: a new route to NAADP.
Topics: Animals; Calcium Signaling; Humans; Metabolic Networks and Pathways; NADP; Second Messenger Systems | 2008 |
Nicotinic acid adenine dinucleotide phosphate (NAADP) and Ca2+ mobilization.
Topics: Animals; Calcium Signaling; Humans; NADP; Oxidation-Reduction; Receptors, Cell Surface | 2008 |
Investigating cADPR and NAADP in intact and broken cell preparations.
Topics: Animals; Calcium; Cyclic ADP-Ribose; Hydrogen-Ion Concentration; NADP; Organelles; Ovum; Permeability; Sea Urchins; Second Messenger Systems | 2008 |
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
Topics: Animals; Calcium Channels; Calcium Signaling; Endosomes; Humans; Ion Channel Gating; Lysosomes; Models, Molecular; NADP; Phylogeny | 2009 |
Calcium signaling via two-pore channels: local or global, that is the question.
Topics: Animals; Binding Sites; Calcium; Calcium Channels; Calcium Signaling; Endoplasmic Reticulum; Endosomes; Humans; Ion Channel Gating; Kinetics; Lysosomes; NADP; Sarcoplasmic Reticulum | 2010 |
TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP.
Topics: Animals; Calcium; Calcium Channels; Humans; NADP; Organelles; Plants; Protein Transport | 2010 |
The role of intracellular ion channels in regulating cytoplasmic calciumin pulmonary arterial mmooth muscle: which store and where?
Topics: ADP-ribosyl Cyclase; Animals; Calcium; Calcium Signaling; Cytoplasm; Hypoxia; Indoles; Ion Channels; Lysosomes; Muscle, Smooth, Vascular; NADP; Pulmonary Artery; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Vasoconstriction; Vasodilation | 2010 |
Two-pore channels: Regulation by NAADP and customized roles in triggering calcium signals.
Topics: Animals; Calcium; Calcium Signaling; Endoplasmic Reticulum; Humans; Ion Channels; NADP; Ryanodine Receptor Calcium Release Channel | 2010 |
NAADP receptors.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Endoplasmic Reticulum; Lysosomes; Models, Biological; NADP; Ovum; Sea Urchins | 2011 |
Endolysosomal calcium regulation and disease.
Topics: Calcium; Calcium Channels; Endosomes; Homeostasis; Humans; Lysosomal Storage Diseases; Lysosomes; NADP | 2010 |
From eggs to hearts: what is the link between cyclic ADP-ribose and ryanodine receptors?
Topics: Animals; Calcium Signaling; Cyclic ADP-Ribose; Fertilization; Heart; Humans; NADP; Ovum; Protein Binding; Ryanodine Receptor Calcium Release Channel; Sea Urchins; Tacrolimus Binding Proteins | 2012 |
Sea urchin eggs in the acid reign.
Topics: Acids; Animals; Antiporters; Calcium; Calcium Channels; Calcium Signaling; Calcium-Transporting ATPases; Cation Transport Proteins; Cyclic ADP-Ribose; Cytoplasmic Vesicles; Fertilization; Hydrogen-Ion Concentration; NADP; Ovum; Sea Urchins | 2011 |
The plant vacuole: emitter and receiver of calcium signals.
Topics: Arabidopsis; Arabidopsis Proteins; Calcium Channels; Calcium Signaling; Calmodulin; Carrier Proteins; Cell Membrane Permeability; Cytosol; Inositol Phosphates; Intracellular Membranes; NADP; Phosphorylation; Plant Cells; Plant Stomata; Vacuoles | 2011 |
Aberrant Ca(2+) signalling through acidic calcium stores in pancreatic acinar cells.
Topics: Acids; Acinar Cells; Bile Acids and Salts; Calcium; Calcium Signaling; Cholecystokinin; Cyclic ADP-Ribose; Endoplasmic Reticulum; Fatty Acids, Monounsaturated; Humans; Inositol 1,4,5-Trisphosphate Receptors; NADP; Pancreas, Exocrine; Pancreatitis; Secretory Vesicles; Vacuolar Proton-Translocating ATPases | 2011 |
The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels.
Topics: Acids; Animals; Calcium; Calcium Channels; Cell Membrane; Endosomes; Humans; Ion Channel Gating; Lysosomes; NADP; Potassium Channels, Voltage-Gated; Sodium Channels; Sodium-Calcium Exchanger | 2011 |
Lysosomal Ca(2+) homeostasis: role in pathogenesis of lysosomal storage diseases.
Topics: Calcium Signaling; Chediak-Higashi Syndrome; Endocytosis; Endosomes; Homeostasis; Humans; Intracellular Membranes; Lysosomal Storage Diseases; Lysosomes; Mucolipidoses; NADP; Niemann-Pick Disease, Type C; Sphingosine; Transient Receptor Potential Channels; TRPM Cation Channels | 2011 |
Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling.
Topics: ADP-ribosyl Cyclase 1; Animals; Calcium; Calcium Signaling; Cyclic ADP-Ribose; Endoplasmic Reticulum; Humans; Inositol 1,4,5-Trisphosphate; Lysosomes; Models, Molecular; Molecular Structure; NADP; Protein Conformation; Ryanodine Receptor Calcium Release Channel | 2011 |
Physiological roles of NAADP-mediated Ca2+ signaling.
Topics: Animals; Calcium; Calcium Signaling; Cell Membrane; Endosomes; Humans; Ion Channel Gating; Ion Channels; Lysosomes; NADP | 2011 |
Intracellular Ca(2+) channels - a growing community.
Topics: Animals; Calcium; Calcium Signaling; Cell Membrane; Endoplasmic Reticulum; Humans; Inositol 1,4,5-Trisphosphate Receptors; Ion Transport; NADP; Ryanodine Receptor Calcium Release Channel | 2012 |
Spatial organization of intracellular Ca2+ signals.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Cell Communication; Cytosol; Diffusion; Humans; Lysosomes; NADP; Protein Binding; Protein Interaction Maps; Protein Transport | 2012 |
Pyridine nucleotide metabolites and calcium release from intracellular stores.
Topics: Animals; Calcium; Calcium Signaling; Cyclic ADP-Ribose; Humans; NADP | 2012 |
NAADP on target.
Topics: Animals; Calcium Channels; Calcium Signaling; Humans; NADP; Sea Urchins; Structure-Activity Relationship | 2012 |
Linking NAADP to ion channel activity: a unifying hypothesis.
Topics: Animals; Calcium; Gene Knockdown Techniques; Humans; Lysosomes; NADP; Second Messenger Systems; Transient Receptor Potential Channels | 2012 |
Roles of cADPR and NAADP in pancreatic cells.
Topics: ADP-ribosyl Cyclase 1; Animals; Calcium; Cyclic ADP-Ribose; Endoplasmic Reticulum; Humans; Lysosomes; Models, Biological; NADP; Pancreas; Second Messenger Systems | 2012 |
Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization.
Topics: ADP-ribosyl Cyclase 1; Animals; Calcium; Calcium Signaling; Catalysis; Catalytic Domain; Crystallography, X-Ray; Cyclic ADP-Ribose; Humans; Hydrogen-Ion Concentration; Lysosomes; Molecular Conformation; NADP; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Signal Transduction | 2012 |
Fertilization in echinoderms.
Topics: Acrosome Reaction; Actins; Animals; Calcium; Calcium Signaling; Cyclic ADP-Ribose; Cytoskeleton; Exocytosis; Male; Meiosis; NADP; Ovum; Sea Urchins; Spermatozoa; Starfish | 2012 |
A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling.
Topics: Autophagy; Calcium Signaling; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Lysosomes; Mutation; NADP; Parkinson Disease; Protein Serine-Threonine Kinases | 2012 |
[Nicotinic acid adenine dinucleotide phosphate--the regulatory substance for Ca2+ releasing].
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Humans; NADP | 2012 |
Calcium pathway machinery at fertilization in echinoderms.
Topics: Animals; Calcium Channels; Calcium Signaling; Cyclic ADP-Ribose; Echinodermata; Fertilization; NADP | 2013 |
Regulation of ion channels by pyridine nucleotides.
Topics: Animals; Binding Sites; Calcium Signaling; Carrier Proteins; Cations; Cyclic ADP-Ribose; Eukaryotic Cells; Homeostasis; Humans; Ion Channel Gating; Ion Channels; Ion Transport; Mammals; NAD; NADP; Phosphorylation; Potassium; Prokaryotic Cells; Sodium | 2013 |
[Calcium signaling in platelet activation].
Topics: Calcium; Calcium Channels; Calcium Signaling; Humans; Inositol 1,4,5-Trisphosphate; Membrane Proteins; NADP; Neoplasm Proteins; ORAI1 Protein; Platelet Activation; Stromal Interaction Molecule 1 | 2012 |
NAADP signaling revisited.
Topics: Animals; Calcium; Humans; NADP; Signal Transduction | 2013 |
Ca(2+) signals, NAADP and two-pore channels: role in cellular differentiation.
Topics: Animals; Calcium Channels; Calcium Signaling; Cell Differentiation; Humans; NADP | 2014 |
Acidic intracellular Ca(2+) stores and caveolae in Ca(2+) signaling and diabetes.
Topics: Acids; Calcium; Calcium Channels; Calcium Signaling; Caveolae; Cytoplasm; Diabetes Mellitus; Humans; Lysosomes; NADP | 2014 |
A primer of NAADP-mediated Ca(2+) signalling: From sea urchin eggs to mammalian cells.
Topics: Animals; Calcium Channels; Calcium Signaling; Endosomes; Lysosomes; NADP; Ovum; Sea Urchins | 2015 |
Calcium mobilizing second messengers derived from NAD.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Cyclic ADP-Ribose; Humans; NAD; NADP; Second Messenger Systems | 2015 |
TPC: the NAADP discovery channel?
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Endosomes; Lipid Metabolism; Lysosomes; Membrane Potentials; NADP | 2015 |
Designer small molecules to target calcium signalling.
Topics: Adenosine; Adenosine Diphosphate Ribose; Arrhythmias, Cardiac; Calcium; Calcium Channel Blockers; Calcium Signaling; Humans; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; NADP; Ryanodine Receptor Calcium Release Channel; Small Molecule Libraries; Structure-Activity Relationship | 2015 |
Two-pore channels at the intersection of endolysosomal membrane traffic.
Topics: Calcium; Calcium Channels; Calcium Signaling; Endosomes; Humans; Lysosomes; NADP; Protein Transport; rab GTP-Binding Proteins | 2015 |
Function and dysfunction of two-pore channels.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Endosomes; Humans; Lysosomes; Models, Biological; NADP | 2015 |
Calcium signals regulated by NAADP and two-pore channels--their role in development, differentiation and cancer.
Topics: Animals; Calcium; Calcium Signaling; Cell Differentiation; Endoplasmic Reticulum; Humans; NADP; Neoplasms; Ryanodine Receptor Calcium Release Channel | 2015 |
Ca(2+) microdomains, NAADP and type 1 ryanodine receptor in cell activation.
Topics: Animals; Calcium; Calcium Signaling; Humans; Lymphocyte Activation; Membrane Microdomains; Models, Biological; NADP; Ryanodine Receptor Calcium Release Channel; T-Lymphocytes | 2016 |
Exploring the biophysical evidence that mammalian two-pore channels are NAADP-activated calcium-permeable channels.
Topics: Animals; Calcium; Calcium Channels; Humans; Lysosomes; NADP | 2016 |
Modulation of Calcium Entry by the Endo-lysosomal System.
Topics: Animals; Calcium; Endosomes; Humans; Lysosomes; NADP; TRPC Cation Channels | 2016 |
Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions.
Topics: Animals; Humans; Ion Channels; NADP; Phosphatidylinositol Phosphates | 2017 |
NAD and the aging process: Role in life, death and everything in between.
Topics: ADP-ribosyl Cyclase 1; Aging; Animals; Armadillo Domain Proteins; Caloric Restriction; Cyclic ADP-Ribose; Cytoskeletal Proteins; Humans; Membrane Glycoproteins; Mitochondria; NAD; NADP; Oxidation-Reduction; Poly(ADP-ribose) Polymerases; Protein Processing, Post-Translational; Signal Transduction; Sirtuins | 2017 |
Thinking through acidic Ca
Topics: Calcium; Calcium Signaling; Hippocampus; Long-Term Potentiation; NADP; Receptors, Metabotropic Glutamate | 2018 |
Probing Ca
Topics: Animals; Calcium; Calcium Signaling; Cell-Free System; Cyclic ADP-Ribose; Kinetics; NADP; Ovum; Proteins; Sea Urchins | 2019 |
NAADP Receptors.
Topics: Animals; Calcium; Calcium Signaling; Humans; NADP; Organelles; Receptors, Cell Surface | 2019 |
Resolving the topological enigma in Ca
Topics: ADP-ribosyl Cyclase 1; Animals; Calcium Signaling; Calcium-Binding Proteins; Cyclic ADP-Ribose; Cytoskeletal Proteins; Humans; Molecular Chaperones; NADP; RNA, Guide, Kinetoplastida | 2019 |
25 Years of Collaboration with A Genius: Deciphering Adenine Nucleotide Ca
Topics: Adenine Nucleotides; Calcium; Calcium Signaling; Endoplasmic Reticulum; Humans; NADP; Second Messenger Systems; Structure-Activity Relationship; T-Lymphocytes | 2020 |
NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications.
Topics: Animals; Antioxidants; Cellular Reprogramming; Homeostasis; Humans; NADP; Neoplasms; Oxidative Stress | 2020 |
NAD
Topics: Aging; Cyclic ADP-Ribose; Humans; Metabolic Diseases; NAD; NADP; Neoplasms; Neurodegenerative Diseases; Oxidation-Reduction | 2020 |
Teaming with NAADP.
Topics: Calcium Signaling; NADP | 2021 |
NAADP-binding proteins find their identity.
Topics: Calcium; Calcium Channels; Calcium Signaling; Carrier Proteins; Lysosomes; NADP | 2022 |
Activation of endo-lysosomal two-pore channels by NAADP and PI(3,5)P
Topics: Calcium; Calcium Channels; Endosomes; Lysosomes; NADP | 2022 |
Roles of cADPR and NAADP in pancreatic beta cell signaling.
Topics: Calcium; Calcium Signaling; Cyclic ADP-Ribose; Insulin-Secreting Cells; NADP | 2022 |
Diversity of two-pore channels and the accessory NAADP receptors in intracellular Ca
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Lysosomes; Mammals; NADP | 2022 |
NAADP-binding proteins - Linking NAADP signaling to cancer and immunity.
Topics: Carrier Proteins; Humans; NADP; Neoplasms; Second Messenger Systems; Signal Transduction | 2023 |
309 other study(ies) available for naadp and nadp
| Article | Year |
|---|---|
Nicotinic acid adenine dinucleotide phosphate (NAADP+).
Topics: Animals; Cattle; Chromatography, Ion Exchange; Methods; NAD+ Nucleosidase; NADP; Spleen | 1980 |
Specific modulation of cyclic ADP-ribose-induced Ca2+ release by polyamines.
Topics: Adenosine Diphosphate Ribose; Animals; Caffeine; Calcium; Cyclic ADP-Ribose; Inositol 1,4,5-Trisphosphate; NADP; Ovum; Polyamines; Ryanodine; Sea Urchins; Spermine | 1995 |
Enzymatic synthesis and degradation of nicotinate adenine dinucleotide phosphate (NAADP), a Ca(2+)-releasing agonist, in rat tissues.
Topics: Animals; Biological Transport; Brain; Calcium; Heart; Kidney Cortex; Liver; Male; Myocardium; N-Glycosyl Hydrolases; NAD+ Nucleosidase; NADP; Niacin; Rats; Rats, Sprague-Dawley; Sea Urchins; Spleen | 1995 |
A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Cyclic ADP-Ribose; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Magnetic Resonance Spectroscopy; Microsomes; NADP; Ovum; Sea Urchins | 1995 |
Nicotinate adenine dinucleotide phosphate (NAADP) triggers a specific calcium release system in sea urchin eggs.
Topics: Animals; Calcium; Female; Fertilization; Kinetics; Mass Spectrometry; NADP; Ovum; Sea Urchins; Structure-Activity Relationship | 1995 |
Ca2+ release triggered by nicotinate adenine dinucleotide phosphate in intact sea urchin eggs.
Topics: Animals; Calcium; Female; Fertilization; Heparin; Inositol 1,4,5-Trisphosphate; Microinjections; Microscopy, Confocal; NADP; Ovum; Sea Urchins | 1995 |
Activation and inactivation of Ca2+ release by NAADP+.
Topics: Animals; Calcium; Cell Compartmentation; Microsomes; NADP; Ovum; Sea Urchins | 1996 |
Nicotinic acid-adenine dinucleotide phosphate mobilizes Ca2+ from a thapsigargin-insensitive pool.
Topics: Adenosine Diphosphate Ribose; Adenosine Triphosphate; Animals; Calcium; Calcium-Transporting ATPases; Cyclic ADP-Ribose; Drug Resistance; Enzyme Inhibitors; Female; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Ion Transport; NADP; Organelles; Ovum; Sea Urchins; Terpenes; Thapsigargin | 1996 |
Unique inactivation properties of NAADP-sensitive Ca2+ release.
Topics: Animals; Calcium; Female; NADP; Ovum; Sea Urchins | 1996 |
Nicotinate-adenine dinucleotide phosphate-induced Ca(2+)-release does not behave as a Ca(2+)-induced Ca(2+)-release system.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Cyclic ADP-Ribose; Egtazic Acid; Enzyme Inhibitors; Female; Gallic Acid; Kinetics; NADP; Ovum; Sea Urchins; Terpenes; Thapsigargin | 1996 |
Caged nicotinic acid adenine dinucleotide phosphate. Synthesis and use.
Topics: Animals; Calcium; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Microsomes; NADP; Ovum; Sea Urchins | 1997 |
Kinetic properties of nicotinic acid adenine dinucleotide phosphate-induced Ca2+ release.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Female; Kinetics; NADP; Ovum; Sea Urchins | 1997 |
Preparation of cyclic ADP-ribose, 2'-phospho-cyclic ADP-ribose, and nicotinate adenine dinucleotide phosphate: possible second messengers of calcium signaling.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Aplysia; Calcium; Cyclic ADP-Ribose; Cyclic AMP; Enzymes, Immobilized; Lyases; N-Glycosyl Hydrolases; NAD; NADP; Nucleotides, Cyclic; Second Messenger Systems | 1997 |
Structural determinants of nicotinic acid adenine dinucleotide phosphate important for its calcium-mobilizing activity.
Topics: Animals; Calcium; NADP; Niacin; Sea Urchins; Structure-Activity Relationship | 1997 |
Pharmacological properties of the Ca2+-release mechanism sensitive to NAADP in the sea urchin egg.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Calcium Channel Blockers; Cyclic ADP-Ribose; Female; Hydrogen-Ion Concentration; NADP; Ovum; Sea Urchins | 1997 |
Cyclic GMP-dependent and -independent effects on the synthesis of the calcium messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate.
Topics: Adenosine Diphosphate Ribose; Adenosine Triphosphate; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Calcium; Cyclic ADP-Ribose; Cyclic GMP; Kinetics; NAD+ Nucleosidase; NADP; Ovum; Sea Urchins | 1998 |
Calcium signaling by cyclic ADP-ribose, NAADP, and inositol trisphosphate are involved in distinct functions in ascidian oocytes.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Calcium; Chelating Agents; Cyclic ADP-Ribose; Electrophysiology; Fertilization; Inositol 1,4,5-Trisphosphate; NAD; NAD+ Nucleosidase; NADP; Oocytes; Patch-Clamp Techniques; Ryanodine; Signal Transduction; Urochordata | 1998 |
Diversity of Ca(2+)-mobilizing mechanisms focus on "cGMP-mediated Ca2+ release from IP3-insensitive Ca2+ stores in smooth muscle".
Topics: Adenosine Diphosphate Ribose; Animals; Biological Transport; Calcium; Cyclic ADP-Ribose; Cyclic GMP; Inositol 1,4,5-Trisphosphate; Muscle, Smooth; NADP | 1998 |
Characterization and application of photogeneration of calcium mobilizers cADP-ribose and nicotinic acid adenine dinucleotide phosphate from caged analogs.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Cyclic ADP-Ribose; Female; Ion Transport; Molecular Probes; NADP; Ovum; Photochemistry; Photolysis; Sea Urchins | 1998 |
InsP3, but not novel Ca2+ releasers, contributes to agonist-initiated contraction in rabbit airway smooth muscle.
Topics: Adenosine Diphosphate Ribose; Administration, Topical; Anesthetics, Local; Animals; Anti-Inflammatory Agents; Anticoagulants; Bronchi; Caffeine; Calcium; Carbachol; Central Nervous System Stimulants; Dimethyl Sulfoxide; Guanosine Triphosphate; Guinea Pigs; Heparin; Humans; Ileum; Immunosuppressive Agents; Inositol 1,4,5-Trisphosphate; Muscle Contraction; Muscle, Smooth; NADP; Parasympathomimetics; Procaine; Rabbits; Ryanodine; Species Specificity; Tacrolimus; Trachea; Type C Phospholipases | 1998 |
Differential effect of pH upon cyclic-ADP-ribose and nicotinate-adenine dinucleotide phosphate-induced Ca2+ release systems.
Topics: Adenosine Diphosphate Ribose; Animals; Caffeine; Calcium; Cyclic ADP-Ribose; Female; Hydrogen-Ion Concentration; Kinetics; NADP; Oocytes; Sea Urchins; Thimerosal; Tritium | 1998 |
Fluorescent analogs of NAADP with calcium mobilizing activity.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Calcium; Female; Fluorescent Dyes; In Vitro Techniques; Ion Transport; Magnetic Resonance Spectroscopy; NAD+ Nucleosidase; NADP; Ovum; Sea Urchins; Spectrometry, Fluorescence | 1998 |
Mechanisms of calcium release and sequestration in eggs of Chaetopterus pergamentaceus.
Topics: Adenosine Diphosphate Ribose; Animals; Caffeine; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cell Extracts; Cyclic ADP-Ribose; Female; Heparin; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Male; NADP; Ovum; Polychaeta; Receptors, Cytoplasmic and Nuclear; Ryanodine; Spermatozoa; Thapsigargin; Thimerosal | 1998 |
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Calcium Signaling; Cyclic ADP-Ribose; Heparin; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Mice; NADP; Pancreas; Sea Urchins | 1999 |
Differential effect of glycolytic intermediaries upon cyclic ADP-ribose-, inositol 1',4',5'-trisphosphate-, and nicotinate adenine dinucleotide phosphate-induced Ca(2+) release systems.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium Signaling; Cyclic ADP-Ribose; Female; Fructosediphosphates; Glycolysis; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; NADP; Oocytes; Ryanodine Receptor Calcium Release Channel; Sea Urchins | 1999 |
Synthesis of NAADP and cADPR in mitochondria.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Cell Compartmentation; Cell Membrane; Cyclic ADP-Ribose; Dithiothreitol; Glycosylphosphatidylinositols; Guanine Nucleotides; Isoenzymes; Membrane Glycoproteins; Mitochondria, Liver; Multienzyme Complexes; NAD; NAD+ Nucleosidase; NADP; Niacinamide; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Rats; Rats, Sprague-Dawley; Type C Phospholipases | 1999 |
Nicotinic acid adenine dinucleotide phosphate-induced Ca(2+) release. Interactions among distinct Ca(2+) mobilizing mechanisms in starfish oocytes.
Topics: Adenine; Age Factors; Animals; Calcium Channel Blockers; Calcium Signaling; NADP; Oocytes; Starfish | 2000 |
Mobilization of Ca2+ stores in individual pancreatic beta-cells permeabilized or not with digitonin or alpha-toxin.
Topics: Adenosine Diphosphate Ribose; Adenosine Triphosphate; Animals; Bacterial Toxins; Caffeine; Calcimycin; Calcium; Calcium-Transporting ATPases; Cell Compartmentation; Cell Membrane Permeability; Cyclic ADP-Ribose; Cytoplasm; Digitonin; Enzyme Inhibitors; Hemolysin Proteins; Inositol 1,4,5-Trisphosphate; Ionophores; Islets of Langerhans; Mice; Mice, Obese; NADP; Organelles; Ryanodine; Ryanodine Receptor Calcium Release Channel; Thapsigargin | 2000 |
Two different but converging messenger pathways to intracellular Ca(2+) release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate.
Topics: Acetylcholine; Adenosine Diphosphate Ribose; Animals; Caffeine; Calcium; Calcium Channels; Calcium Signaling; Cell Line; Cholecystokinin; Cyclic ADP-Ribose; Drug Synergism; Endoplasmic Reticulum; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Intracellular Fluid; Ion Transport; Mice; NADP; Pancreas; Patch-Clamp Techniques; Receptors, Cell Surface; Receptors, Cholecystokinin; Receptors, Cytoplasmic and Nuclear; Ryanodine Receptor Calcium Release Channel | 2000 |
Calcium release from the endoplasmic reticulum of higher plants elicited by the NADP metabolite nicotinic acid adenine dinucleotide phosphate.
Topics: Brassica; Calcium; Chenopodiaceae; Endoplasmic Reticulum, Rough; Intracellular Membranes; Microsomes; NADP; Plant Roots | 2000 |
Nicotinic acid adenine dinucleotide phosphate (NAADP(+)) is an essential regulator of T-lymphocyte Ca(2+)-signaling.
Topics: Adenosine Diphosphate Ribose; Calcium Signaling; CD3 Complex; Cyclic ADP-Ribose; Dose-Response Relationship, Drug; Humans; Image Processing, Computer-Assisted; Inositol 1,4,5-Trisphosphate; Jurkat Cells; Lymphocyte Activation; Microinjections; NADP; Receptors, Antigen, T-Cell; Ryanodine Receptor Calcium Release Channel; T-Lymphocytes | 2000 |
Two neuropeptides recruit different messenger pathways to evoke Ca2+ signals in the same cell.
Topics: Animals; Bombesin; Caffeine; Calcium; Calcium Channels; Calcium Signaling; Cholecystokinin; Inositol 1,4,5-Trisphosphate Receptors; Mice; NADP; Pancreas; Receptors, Cytoplasmic and Nuclear | 2000 |
Characterization of NAADP(+) binding in sea urchin eggs.
Topics: Animals; Calcium Channels; Inositol 1,4,5-Trisphosphate Receptors; NADP; Ovum; Protein Binding; Radioligand Assay; Receptors, Cytoplasmic and Nuclear; Ryanodine Receptor Calcium Release Channel; Sea Urchins | 2000 |
Spatial control of Ca2+ signaling by nicotinic acid adenine dinucleotide phosphate diffusion and gradients.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Calcium Signaling; Cyclic ADP-Ribose; Diffusion; Female; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; NADP; Oocytes; Sea Urchins | 2000 |
Widespread distribution of binding sites for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate, in the brain.
Topics: Animals; Binding Sites; Calcium; Cells, Cultured; Male; NADP; Rats; Rats, Sprague-Dawley; Sea Urchins; Signal Transduction | 2000 |
Functional visualization of the separate but interacting calcium stores sensitive to NAADP and cyclic ADP-ribose.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Calcium Signaling; Calcium-Transporting ATPases; Cyclic ADP-Ribose; NADP; Sea Urchins | 2000 |
Unique kinetics of nicotinic acid-adenine dinucleotide phosphate (NAADP) binding enhance the sensitivity of NAADP receptors for their ligand.
Topics: Adenosine Diphosphate Ribose; Animals; Binding Sites; Calcium; Calcium Signaling; Cell Extracts; Cyclic ADP-Ribose; Hydrogen-Ion Concentration; Inositol 1,4,5-Trisphosphate; Kinetics; Ligands; NADP; Ovum; Protein Binding; Sea Urchins; Sodium Chloride | 2000 |
Nicotinic acid adenine dinucleotide phosphate: a new Ca2+ releasing agent in kidney.
Topics: Animals; Calcium Signaling; Glomerular Mesangium; In Vitro Techniques; Kidney; Male; Microsomes; NADP; Rats; Rats, Sprague-Dawley | 2001 |
Prolonged inactivation of nicotinic acid adenine dinucleotide phosphate-induced Ca2+ release mediates a spatiotemporal Ca2+ memory.
Topics: Animals; Calcium; Ion Transport; NADP; Sea Urchins; Signal Transduction | 2001 |
Nicotinic acid-adenine dinucleotide phosphate (NAADP) elicits specific microsomal Ca2+ release from mammalian cells.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Cells, Cultured; Cyclic ADP-Ribose; Glomerular Mesangium; Hydrogen-Ion Concentration; Inositol 1,4,5-Trisphosphate; Microsomes; NADP; Radioligand Assay; Rats; Rats, Sprague-Dawley; Ryanodine | 2001 |
Role of Ins(1,4,5)P3, cADP-ribose and nicotinic acid-adenine dinucleotide phosphate in Ca2+ signalling in mouse submandibular acinar cells.
Topics: Acetylcholine; Adenosine Diphosphate Ribose; Animals; Calcium Signaling; Cyclic ADP-Ribose; Inositol 1,4,5-Trisphosphate; Male; Mice; NADP; Submandibular Gland | 2001 |
Effect of nicotinic acid adenine dinucleotide phosphate on ryanodine calcium release channel in heart.
Topics: Animals; Calcium; Calcium Radioisotopes; Dogs; Dose-Response Relationship, Drug; In Vitro Techniques; Membrane Potentials; Microsomes; Myocardium; NADP; Rats; Ryanodine Receptor Calcium Release Channel | 2001 |
NAADP induces Ca2+ oscillations via a two-pool mechanism by priming IP3- and cADPR-sensitive Ca2+ stores.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Calcium Channels; Calcium Signaling; Cyclic ADP-Ribose; Female; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Kinetics; Models, Biological; NADP; Oocytes; Oscillometry; Receptors, Cytoplasmic and Nuclear; Ryanodine Receptor Calcium Release Channel; Sea Urchins; Thapsigargin | 2001 |
Hypotonic swelling-induced Ca(2+) release by an IP(3)-insensitive Ca(2+) store.
Topics: Animals; Calcium; Cell Line; Enzyme Inhibitors; Hypotonic Solutions; Inositol 1,4,5-Trisphosphate; Intracellular Membranes; Muscle, Smooth, Vascular; NADP; Osmolar Concentration; Ryanodine; Thapsigargin | 2001 |
NAADP receptors are present and functional in the heart.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Calcium Channel Blockers; Cyclic ADP-Ribose; Diltiazem; Indicators and Reagents; Kinetics; Microsomes; Myocardium; NADP; Protein Binding; Radioligand Assay; Receptors, Cell Surface; Ruthenium Red; Ryanodine; Verapamil | 2001 |
Nicotinic acid adenine dinucleotide phosphate enhances quantal neurosecretion at the frog neuromuscular junction: possible action on synaptic vesicles in the releasable pool.
Topics: Adenosine Diphosphate Ribose; Animals; Calcimycin; Cyclic ADP-Ribose; Drug Interactions; Enzyme Inhibitors; Inositol 1,4,5-Trisphosphate; NADP; Neuromuscular Junction; Neurosecretion; Rana pipiens; Synaptic Vesicles; Thapsigargin | 2001 |
Lack of effect of cADP-ribose and NAADP on the activity of skeletal muscle and heart ryanodine receptors.
Topics: Adenosine Diphosphate Ribose; Animals; Binding Sites; Calcium; Calmodulin; Cyclic ADP-Ribose; Dogs; Lipid Bilayers; Muscle, Skeletal; Myocardium; NADP; Rabbits; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Tacrolimus Binding Proteins | 2001 |
NAADP+ initiates the Ca2+ response during fertilization of starfish oocytes.
Topics: Animals; Calcium Signaling; Cell Nucleus; Cells, Cultured; Exocytosis; Fertilization; Inositol 1,4,5-Trisphosphate; Kinetics; Male; Maturation-Promoting Factor; Microscopy, Confocal; NADP; Oocytes; Spermatozoa; Starfish | 2001 |
Ryanodine-, IP3- and NAADP-dependent calcium stores control acetylcholine release.
Topics: Acetylcholine; Animals; Aplysia; Biological Transport; Calcium; Cheek; Ganglia; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Intracellular Membranes; NADP; Ryanodine; Ryanodine Receptor Calcium Release Channel; Synaptic Transmission | 2001 |
Differential mechanisms of Ca(2+) release from vascular smooth muscle cell microsomes.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Cells, Cultured; Cyclic ADP-Ribose; Inositol 1,4,5-Trisphosphate; Male; Microsomes; Muscle, Smooth, Vascular; NADP; Rats; Rats, Sprague-Dawley; Signal Transduction | 2002 |
Ca(2+) response to cADPr during maturation and fertilization of starfish oocytes.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium Channel Blockers; Calcium Signaling; Cyclic ADP-Ribose; Fertilization; Kinetics; Meiosis; Microinjections; NADP; Nifedipine; Oocytes; Photochemistry; Starfish | 2002 |
Cell side-specific sensitivities of intracellular Ca2+ stores for inositol 1,4,5-trisphosphate, cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate in permeabilized pancreatic acinar cells from mouse.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Cell Membrane; Cyclic ADP-Ribose; Cytoplasm; Dose-Response Relationship, Drug; Fluorescent Dyes; Fura-2; Heparin; Inositol 1,4,5-Trisphosphate; Mice; Microscopy, Confocal; Models, Biological; NADP; Pancreas; Protein Binding | 2002 |
CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Calcium Signaling; Cyclic ADP-Ribose; Male; Membrane Glycoproteins; Mice; Mice, Knockout; NAD+ Nucleosidase; NADP; Rats; Rats, Sprague-Dawley | 2002 |
Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers.
Topics: Acetylcholine; Adenosine Diphosphate Ribose; Animals; Caffeine; Calcium Channels; Calcium Signaling; Cell Polarity; Cholecystokinin; Cyclic ADP-Ribose; Exocytosis; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Mice; NADP; Pancreas; Patch-Clamp Techniques; Receptors, Cell Surface; Receptors, Cholecystokinin; Receptors, Cholinergic; Receptors, Cytoplasmic and Nuclear; Second Messenger Systems; Sincalide | 2002 |
Metabolism of the novel Ca2+-mobilizing messenger nicotinic acid-adenine dinucleotide phosphate via a 2'-specific Ca2+-dependent phosphatase.
Topics: Adenosine Monophosphate; Animals; Brain; Calcium Signaling; In Vitro Techniques; Male; Membranes; Mice; NAD; NADP; Phosphoric Monoester Hydrolases; Phosphorylation | 2002 |
Interactions between intracellular Ca2+ stores: Ca2+ released from the NAADP pool potentiates cADPR-induced Ca2+ release.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Cyclic ADP-Ribose; Inositol 1,4,5-Trisphosphate; NADP; Ovum; Sea Urchins | 2002 |
Nicotinic acid-adenine dinucleotide phosphate activates the skeletal muscle ryanodine receptor.
Topics: ADP-ribosyl Cyclase; Animals; Calcium; Cyclic ADP-Ribose; Muscle, Skeletal; NADP; Rabbits; Ruthenium Red; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum | 2002 |
Stretch-induced Ca(2+) release via an IP(3)-insensitive Ca(2+) channel.
Topics: Actins; Animals; Calcium; Calcium Channels; Cell Line; Cytochalasin D; Drug Resistance; Gadolinium; Heparin; Inositol 1,4,5-Trisphosphate; Intracellular Membranes; Ion Channels; Lanthanum; Microtubules; NADP; Nocodazole; Ryanodine; Stress, Mechanical | 2002 |
A novel cycling assay for nicotinic acid-adenine dinucleotide phosphate with nanomolar sensitivity.
Topics: Alcohol Dehydrogenase; Alkaline Phosphatase; Biochemistry; Calcium; Dose-Response Relationship, Drug; Fungal Proteins; Models, Chemical; NAD; NADP; Niacin; Phosphorylation; Signal Transduction; Time Factors | 2002 |
Calcium signalling: calcium goes global.
Topics: Adenosine Diphosphate Ribose; Calcium Signaling; Cyclic ADP-Ribose; NADP; Pancreas | 2002 |
Effect of luminal and extravesicular Ca2+ on NAADP binding and release properties.
Topics: Animals; Calcium; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Ionomycin; Kinetics; NADP; Protein Binding; Sea Urchins; Time Factors | 2002 |
Solubilization of receptors for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate.
Topics: Animals; Calcium; Centrifugation, Density Gradient; Chromatography, Gel; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Inositol 1,4,5-Trisphosphate; Ligands; NADP; Octoxynol; Protein Binding; Ryanodine Receptor Calcium Release Channel; Sea Urchins; Sucrose; Time Factors | 2002 |
Nicotinic acid adenine dinucleotide phosphate (NAADP) is present at micromolar concentrations in sea urchin spermatozoa.
Topics: Animals; Cell Extracts; Male; NADP; Osmolar Concentration; RNA, Messenger; Sea Urchins; Seawater; Spermatozoa | 2002 |
Nicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human beta cells.
Topics: Caffeine; Calcium Channels; Calcium Signaling; Calcium-Transporting ATPases; Cells, Cultured; Electrophysiology; Humans; Hydroquinones; Inositol 1,4,5-Trisphosphate Receptors; Insulin; Intracellular Fluid; Islets of Langerhans; Macrocyclic Compounds; NADP; Oxazoles; Receptors, Cytoplasmic and Nuclear; Thapsigargin | 2002 |
NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs.
Topics: Animals; Calcium; Calcium Signaling; Cytoplasmic Granules; Female; Lysosomes; Models, Biological; NADP; Organelles; Ovum; Proton Pumps; Sea Urchins | 2002 |
Nicotinic acid adenine dinucleotide phosphate mediates Ca2+ signals and contraction in arterial smooth muscle via a two-pool mechanism.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Cell Compartmentation; Cell Separation; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Male; Microdialysis; Muscle, Smooth, Vascular; NADP; Oxazoles; Patch-Clamp Techniques; Pulmonary Artery; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Ryanodine; Sarcoplasmic Reticulum; Second Messenger Systems; Vasoconstriction | 2002 |
Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6).
Topics: Animals; Base Sequence; Calcium; DNA Primers; Insulin; Islets of Langerhans; Mice; NADP; Rats; Receptors, Cell Surface; RNA, Messenger; Ryanodine Receptor Calcium Release Channel; Tumor Cells, Cultured | 2003 |
Sperm deliver a new second messenger: NAADP.
Topics: Animals; Calcium Channels, L-Type; Calcium Signaling; Female; In Vitro Techniques; Male; NADP; Sea Urchins; Second Messenger Systems; Sperm-Ovum Interactions; Spermatozoa | 2003 |
NAADP: a new second messenger for glucose-induced Ca2+ responses in clonal pancreatic beta cells.
Topics: Animals; Calcium; Cell Line; Glucose; Insulin; Islets of Langerhans; Mice; NADP; Radioligand Assay; Second Messenger Systems | 2003 |
EPYLRFamide-mediated reduction of acetylcholine-induced inward currents in Helix lucorum-identified neurones: role of NAADP-dependent and IP3-dependent Ca2+ release from internal stores, calmodulin and Ca2+/calmodulin-dependent protein kinase II.
Topics: Acetylcholine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Electrophysiology; Enzyme Inhibitors; Helix, Snails; Heparin; Inositol 1,4,5-Trisphosphate; NADP; Neurons; Neuropeptides; Patch-Clamp Techniques; Receptors, Cholinergic; Receptors, Thrombin | 2003 |
Calcium signaling: NAADP ascends as a new messenger.
Topics: Animals; Calcium; Calcium Signaling; NADP; Ovum; Sea Urchins | 2003 |
NAADP on the up in pancreatic beta cells-a sweet message?
Topics: Calcium; Humans; Insulin; Islets of Langerhans; Models, Biological; NADP; Signal Transduction | 2003 |
Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP).
Topics: Animals; Calcium; Calcium Signaling; Cyclic ADP-Ribose; Electrophysiology; Enzyme Inhibitors; Inositol 1,4,5-Trisphosphate; Lysophospholipids; Muscles; NADP; Neuromuscular Junction; Neurotransmitter Agents; Phosphorylcholine; Rana pipiens; Sphingosine; Thapsigargin; Wound Healing | 2003 |
High throughput fluorescence-based assays for cyclic ADP-ribose, NAADP, and their metabolic enzymes.
Topics: ADP-ribosyl Cyclase; Antigens, CD; Calcium Signaling; Cyclic ADP-Ribose; Cyclization; Fluorometry; Glycoside Hydrolases; HL-60 Cells; Humans; N-Glycosyl Hydrolases; NAD; NADP | 2003 |
Modulation of NAADP (nicotinic acid-adenine dinucleotide phosphate) receptors by K+ ions: evidence for multiple NAADP receptor conformations.
Topics: Animals; Binding, Competitive; Calcium; Dose-Response Relationship, Drug; Female; Models, Biological; NADP; Ovum; Phosphorus Radioisotopes; Potassium; Protein Conformation; Radioligand Assay; Receptors, Cytoplasmic and Nuclear; Sea Urchins | 2003 |
NAADP activates a Ca2+ current that is dependent on F-actin cytoskeleton.
Topics: Actin Cytoskeleton; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channels; Calcium Signaling; Cell Membrane; Depsipeptides; Electric Conductivity; Models, Biological; NADP; Oocytes; Patch-Clamp Techniques; Peptides, Cyclic; Starfish; Thiazoles; Thiazolidines | 2003 |
NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors.
Topics: Animals; Calcium; Cyclic ADP-Ribose; Fluorescent Dyes; Inositol 1,4,5-Trisphosphate; Mice; Mice, Inbred Strains; Models, Biological; NADP; Nuclear Envelope; Pancreas; Ryanodine; Ryanodine Receptor Calcium Release Channel; Thapsigargin | 2003 |
Production and characterization of reduced NAADP (nicotinic acid-adenine dinucleotide phosphate).
Topics: Animals; Calcium; Carrier Proteins; Glucosephosphate Dehydrogenase; NADP; Ovum; Oxidation-Reduction; Sea Urchins | 2004 |
Novel Ca2+ signalling mechanisms in vascular myocytes: symposium overview.
Topics: Arterioles; Biological Transport; Calcium; Calcium Signaling; Cyclic ADP-Ribose; Humans; Integrins; Mitochondria; Muscle, Smooth, Vascular; NADP; Potassium Channels | 2003 |
Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.
Topics: Acetylcholine; Animals; Bombesin; Calcium; Cell Line; Endoplasmic Reticulum; Enzyme Inhibitors; Islets of Langerhans; Lysosomes; Macrolides; Male; Mice; Models, Biological; NADP; Organelles; Pancreas; Signal Transduction; Thapsigargin; Time Factors; Ultraviolet Rays | 2004 |
Determination of cellular nicotinic acid-adenine dinucleotide phosphate (NAADP) levels.
Topics: Animals; Cell Extracts; Cell Line; Erythrocytes; Escherichia coli; Hepatocytes; Humans; NADP; Ovum; Radioligand Assay; Rats; Rats, Sprague-Dawley; Sea Urchins; Sensitivity and Specificity | 2004 |
Triazine dyes are agonists of the NAADP receptor.
Topics: Animals; Coloring Agents; Dose-Response Relationship, Drug; Female; Lytechinus; NADP; Protein Binding; Receptors, Cytoplasmic and Nuclear; Second Messenger Systems; Triazines | 2004 |
Ca2+ release via ryanodine receptors and Ca2+ entry: major mechanisms in NAADP-mediated Ca2+ signaling in T-lymphocytes.
Topics: Calcium; Calcium Channel Blockers; Calcium Signaling; Down-Regulation; Gadolinium; Heparin; Humans; Inositol 1,4,5-Trisphosphate; Jurkat Cells; Lymphocyte Activation; NADP; RNA, Antisense; Ruthenium Red; Ryanodine Receptor Calcium Release Channel; Signal Transduction; T-Lymphocytes; Transfection | 2004 |
Chemical synthesis of the second messenger nicotinic acid adenine dinucleotide phosphate by total synthesis of nicotinamide adenine dinucleotide phosphate.
Topics: Animals; Calcium; Ions; Molecular Structure; NADP; Ovum; Sea Urchins; Second Messenger Systems | 2004 |
NAADP triggers the fertilization potential in starfish oocytes.
Topics: Action Potentials; Animals; Calcium Signaling; Female; Fertilization; Male; NADP; Oocytes; Spermatozoa; Starfish | 2004 |
Nicotinic acid adenine dinucleotide phosphate potentiates neurite outgrowth.
Topics: Animals; Calcium; Cell Enlargement; Cell Shape; Cells, Cultured; Inositol Phosphates; Liposomes; Macrocyclic Compounds; Macrolides; NADP; Neurites; Oxazoles; Rats; Ryanodine; Ryanodine Receptor Calcium Release Channel; Thapsigargin | 2005 |
Role of the nicotinic acid group in NAADP receptor selectivity.
Topics: Animals; Binding Sites; Binding, Competitive; Female; NADP; Niacin; Ovum; Protein Binding; Protein Structure, Tertiary; Pyridines; Radioligand Assay; Receptors, Cell Surface; Sea Urchins; Subcellular Fractions | 2005 |
Phosphoinositide metabolism at fertilization of sea urchin eggs measured with a GFP-probe.
Topics: Animals; Base Sequence; Calcium; Cyclic ADP-Ribose; DNA Primers; Green Fluorescent Proteins; Inositol 1,4,5-Trisphosphate; Lytechinus; Molecular Probes; NADP; Ovum; Phosphatidylinositols; Type C Phospholipases | 2004 |
NAADP binding to its target protein in sea urchin eggs requires phospholipids.
Topics: Animals; Cattle; Cell Extracts; Chromatography, Gel; Detergents; Egg Proteins; Ligands; NADP; Octoxynol; Ovum; Phospholipids; Protein Binding; Radioligand Assay; Sea Urchins; Solubility; Substrate Specificity | 2005 |
Purine nucleotides and their metabolites in erythrocytes of streptozotocin diabetic rats.
Topics: Adenine Nucleotides; Adenosine Triphosphatases; Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Erythrocytes; Guanine Nucleotides; Inosine Monophosphate; Male; NAD; NADP; Purine Nucleotides; Rats; Rats, Wistar | 2004 |
To be or not to be ... nicotinic acid adenine dinucleotide phosphate (NAADP): a new intracellular second messenger?
Topics: Animals; Calcium; Calcium Signaling; Humans; Intracellular Fluid; NADP; Second Messenger Systems | 2004 |
Functional ryanodine receptor expression is required for NAADP-mediated local Ca2+ signaling in T-lymphocytes.
Topics: Calcium; Calcium Channel Blockers; Cyclic ADP-Ribose; Humans; Imidazoles; Jurkat Cells; Lymphocyte Activation; Microscopy, Confocal; Microscopy, Fluorescence; NADP; Ruthenium Red; Ryanodine Receptor Calcium Release Channel; Signal Transduction; T-Lymphocytes; Time Factors | 2005 |
Role of NAADP and cADPR in the induction and maintenance of agonist-evoked Ca2+ spiking in mouse pancreatic acinar cells.
Topics: Acetylcholine; Animals; Calcium Signaling; Cholecystokinin; Cyclic ADP-Ribose; Fluorescence; Male; Mice; NADP; Pancreas; Radioligand Assay; Time Factors | 2005 |
Novel second messenger offers drug development opportunities.
Topics: Animals; Cholecystokinin; Diabetes Mellitus, Type 1; Drug Design; Female; Humans; NADP; Second Messenger Systems; Uterine Contraction | 2005 |
Extracellular application of nicotinic acid adenine dinucleotide phosphate induces Ca2+ signaling in astrocytes in situ.
Topics: Adenosine; ADP-ribosyl Cyclase 1; Animals; Astrocytes; Calcium; Cell Line, Tumor; Central Nervous System; Cerebellum; Connexins; Immunohistochemistry; Inositol 1,4,5-Trisphosphate; Lysosomes; Mice; Models, Biological; NADP; Neurons; Oligodendroglia; Signal Transduction; Time Factors | 2005 |
Two distinct Ca2+ compartments show differential sensitivity to thrombin, ADP and vasopressin in human platelets.
Topics: Adenosine Diphosphate; Blood Platelets; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Cell Compartmentation; Estrenes; Humans; Hydroquinones; Inositol 1,4,5-Trisphosphate; Isoenzymes; NADP; Nimodipine; Pyrrolidinones; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thapsigargin; Thrombin; Type C Phospholipases; Vasopressins | 2006 |
Production of calcium-mobilizing metabolites by a novel member of the ADP-ribosyl cyclase family expressed in Schistosoma mansoni.
Topics: ADP-ribosyl Cyclase; Animals; Aplysia; Base Sequence; Calcium; Calcium Signaling; Cloning, Molecular; Cyclic ADP-Ribose; Gene Expression; Molecular Sequence Data; NAD; NAD+ Nucleosidase; NADP; Phylogeny; Schistosoma mansoni | 2005 |
A multifunctional enzyme adds to its repertoire.
Topics: Adenine; ADP-ribosyl Cyclase; Animals; Calcium; Cyclic ADP-Ribose; Molecular Structure; NADP | 2005 |
Chemical synthesis of the novel Ca2+ messenger NAADP.
Topics: Animals; Aplysia; Calcium; Calcium Signaling; Chemistry, Pharmaceutical; Magnetic Resonance Spectroscopy; Models, Chemical; NADP; Second Messenger Systems; Temperature | 2005 |
Calcium mobilization by nicotinic acid adenine dinucleotide phosphate (NAADP) in rat astrocytes.
Topics: Animals; Astrocytes; Calcium Signaling; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Dipeptides; Fluorescent Dyes; In Vitro Techniques; Indoles; Inositol Phosphates; Ionomycin; Macrolides; NADP; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2; Type C Phospholipases | 2006 |
Ca2+ release triggered by NAADP in hepatocyte microsomes.
Topics: Animals; Calcium; Calcium Signaling; Dose-Response Relationship, Drug; Hepatocytes; Hydrogen-Ion Concentration; Liver; Macrolides; Microsomes, Liver; NADP; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Thapsigargin; Time Factors | 2006 |
A transport mechanism for NAADP in a rat basophilic cell line.
Topics: Animals; Autocrine Communication; Basophils; Biological Transport; Calcium; Calcium Signaling; Cell Line, Tumor; Dipyridamole; Leukemia, Basophilic, Acute; NADP; Neuroblastoma; Paracrine Communication; Rats; Second Messenger Systems; Sodium | 2006 |
NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area.
Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Cyclic ADP-Ribose; Endoplasmic Reticulum; Enzyme Inhibitors; Fluorescent Dyes; Hydrogen-Ion Concentration; Inositol 1,4,5-Trisphosphate; Ionophores; Macrolides; Mice; NADP; Nigericin; Pancreas; Secretory Vesicles; Thapsigargin | 2006 |
Production of NAADP and its role in Ca2+ mobilization associated with lysosomes in coronary arterial myocytes.
Topics: Animals; Calcium; Calcium Signaling; Cattle; Cells, Cultured; Coronary Vessels; Dose-Response Relationship, Drug; Endothelin-1; Lysosomes; Myocytes, Cardiac; NADP | 2006 |
NAADP and InsP3 play distinct roles at fertilization in starfish oocytes.
Topics: Animals; Calcium; Calcium Signaling; Electrophysiology; Female; Fertilization; Membrane Potentials; NADP; Oocytes; Phosphotransferases (Alcohol Group Acceptor); Sodium; Starfish | 2006 |
Time sensing by NAADP receptors.
Topics: Animals; Calcium; Calcium Signaling; Cytosol; Ligands; NADP; Oocytes; Protein Binding; Receptors, Cell Surface; Sea Urchins; Temperature; Time Factors | 2006 |
Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes.
Topics: Cyclic ADP-Ribose; Electrophysiology; Humans; Jurkat Cells; NADP; T-Lymphocytes; TRPM Cation Channels | 2006 |
Messenger-specific role for nicotinic acid adenine dinucleotide phosphate in neuronal differentiation.
Topics: Animals; Calcium; Cell Differentiation; Cytosol; NADP; Neurons; PC12 Cells; Rats | 2006 |
Second messenger function of nicotinic acid adenine dinucleotide phosphate revealed by an improved enzymatic cycling assay.
Topics: Biochemistry; Calcium; CD3 Complex; Chromatography, Ion Exchange; Dose-Response Relationship, Drug; Humans; Jurkat Cells; Kinetics; Models, Biological; NAD+ Nucleosidase; NADP; Second Messenger Systems; Signal Transduction; T-Lymphocytes | 2006 |
NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Cell Differentiation; Cells, Cultured; Cyclic ADP-Ribose; Cyclization; HL-60 Cells; Humans; Hydrolysis; Kinetics; NADP; Niacin; Tretinoin | 2006 |
NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Calcium; Cells, Cultured; Female; Histamine; Humans; Inositol 1,4,5-Trisphosphate; Intracellular Membranes; Lysosomes; Mice; Mice, Inbred C57BL; Mice, Knockout; Myometrium; NADP; Ryanodine Receptor Calcium Release Channel; Second Messenger Systems; Signal Transduction | 2007 |
Cell-permeant small-molecule modulators of NAADP-mediated Ca2+ release.
Topics: Animals; Calcium; Cations, Divalent; Cell Membrane Permeability; Cholecystokinin; Molecular Structure; NADP; Ovum; Pyridines; Sea Urchins | 2006 |
Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Binding Sites; Crystallography, X-Ray; Glutamic Acid; Humans; Hydrolysis; Kinetics; Models, Molecular; Mutation; NADP; Pichia; Protein Structure, Tertiary | 2006 |
Modulation of calcium signalling by the actin-binding protein cofilin.
Topics: Actin Depolymerizing Factors; Actins; Animals; Calcium Signaling; Cyclic ADP-Ribose; Inositol Phosphates; NADP; Oocytes; Starfish | 2006 |
Pharmacological characterization of NAADP-induced Ca2+ signals in starfish oocytes.
Topics: Animals; Asterina; Calcium; Calcium Signaling; Membrane Potentials; NADP; Oocytes; Ryanodine Receptor Calcium Release Channel | 2006 |
Generation of specific Ca(2+) signals from Ca(2+) stores and endocytosis by differential coupling to messengers.
Topics: Acetylcholine; Animals; Calcium; Calcium Signaling; Cells, Cultured; Cholecystokinin; Cyclic ADP-Ribose; Endocytosis; Endoplasmic Reticulum; Inositol 1,4,5-Trisphosphate; Lysosomes; NADP; Secretory Vesicles | 2006 |
NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores.
Topics: Animals; Calcium; Cell Membrane; Hydrogen-Ion Concentration; Mammals; Models, Biological; NADP; Second Messenger Systems; Signal Transduction | 2006 |
Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors.
Topics: Animals; Caffeine; Calcium; Endoplasmic Reticulum; Hydrogen-Ion Concentration; Inositol 1,4,5-Trisphosphate Receptors; Intracellular Fluid; Male; Mice; NADP; Pancreas, Exocrine; Ryanodine Receptor Calcium Release Channel; Secretory Vesicles; Signal Transduction; Taurolithocholic Acid | 2006 |
PPADS is a reversible competitive antagonist of the NAADP receptor.
Topics: Animals; Binding, Competitive; Calcium; Calcium Channels; Calcium Signaling; Female; Fluorometry; NADP; Ovum; Pyridines; Pyridoxal Phosphate; Radioligand Assay; Receptors, Purinergic P2; Sea Urchins; Sulfonic Acids | 2007 |
NAADP induces pH changes in the lumen of acidic Ca2+ stores.
Topics: Acids; Animals; Calcium; Cell Membrane; Cytosol; Endoplasmic Reticulum; Hydrogen-Ion Concentration; Ion Transport; NADP; Ovum; Sea Urchins; Vacuolar Proton-Translocating ATPases; Valinomycin | 2007 |
Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose.
Topics: Animals; Calcium; Cell Culture Techniques; Glucose; Insulin-Secreting Cells; Membrane Potentials; Mice; Mice, Inbred Strains; Mitochondria; NADP; Rats; Rats, Sprague-Dawley; Succinates | 2007 |
Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP+).
Topics: ADP-ribosyl Cyclase; Animals; Calcium; Catalysis; Chromatography, High Pressure Liquid; Fertilization; Mass Spectrometry; NADP; Ovum; Photochemistry; Sea Urchins; Structure-Activity Relationship | 2007 |
Fertilization causes a single Ca2+ increase that fully depends on Ca2+ influx in oocytes of limpets (Phylum Mollusca, Class Gastropoda).
Topics: Animals; Caffeine; Calcium; Calcium Signaling; Cyclic ADP-Ribose; Female; Fertilization; Gastropoda; Inositol 1,4,5-Trisphosphate; Male; Meiosis; NADP; Oocytes | 2007 |
NAADP controls cross-talk between distinct Ca2+ stores in the heart.
Topics: Action Potentials; Animals; Calcium; Calcium Channels; Enzyme Inhibitors; Guinea Pigs; Heart Ventricles; Ion Channel Gating; Macrolides; Myocytes, Cardiac; NADP; Proton-Translocating ATPases; Receptors, Adrenergic, beta; Ryanodine; Sarcolemma; Thapsigargin | 2007 |
An enzymatic cycling assay for nicotinic acid adenine dinucleotide phosphate using NAD synthetase.
Topics: Alkaline Phosphatase; Amide Synthases; Animals; Automation; Biological Assay; Evaluation Studies as Topic; Glucose 1-Dehydrogenase; Humans; Hydrogen-Ion Concentration; Models, Chemical; NAD(P)H Dehydrogenase (Quinone); NAD+ Nucleosidase; NADP; Sensitivity and Specificity; Time Factors | 2007 |
NAADP mobilizes calcium from the endoplasmic reticular Ca(2+) store in T-lymphocytes.
Topics: Calcium; Calcium Signaling; Endoplasmic Reticulum; Enzyme Inhibitors; Humans; Jurkat Cells; Lysosomes; Macrolides; NADP; T-Lymphocytes; Thapsigargin | 2007 |
Reconstitution and characterization of a nicotinic acid adenine dinucleotide phosphate (NAADP)-sensitive Ca2+ release channel from liver lysosomes of rats.
Topics: Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydrogen-Ion Concentration; Liver; Lysosomes; Macrolides; Male; Membrane Microdomains; NADP; Proton-Translocating ATPases; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum | 2007 |
NAADP+ is an agonist of the human P2Y11 purinergic receptor.
Topics: Animals; Calcium; Cell Line; Chemotaxis; Cyclic ADP-Ribose; Cyclic AMP; Granulocytes; Humans; Inositol 1,4,5-Trisphosphate; NADP; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2; Signal Transduction | 2008 |
Molecular characterization of a novel intracellular ADP-ribosyl cyclase.
Topics: ADP-ribosyl Cyclase; Amino Acid Sequence; Animals; Calcium Signaling; Cloning, Molecular; Cyclic ADP-Ribose; Cytosol; Endoplasmic Reticulum; Molecular Sequence Data; NADP; Protein Isoforms; Sea Urchins; Sequence Alignment | 2007 |
Infrared multiphoton dissociation and electron-induced dissociation as alternative MS/MS strategies for metabolite identification.
Topics: Adenosine Diphosphate Ribose; Adenosine Triphosphate; Carbohydrates; Electrons; Fourier Analysis; Glucose-6-Phosphate; Glycolysis; Molecular Structure; NAD; NADP; Phosphorylation; Photons; Tandem Mass Spectrometry | 2007 |
Refinement of a radioreceptor binding assay for nicotinic acid adenine dinucleotide phosphate.
Topics: Animals; Calcium; Calcium Signaling; Cell Extracts; Chelating Agents; Chromatography, High Pressure Liquid; Egtazic Acid; Embryo, Nonmammalian; Hydrogen-Ion Concentration; Male; Mice; Mice, Inbred Strains; Microinjections; Models, Biological; NADP; Oocytes; Oxidants; Pancreas, Exocrine; Perchlorates; Phosphorus Radioisotopes; Protein Binding; Radioligand Assay; Sea Urchins; Second Messenger Systems; Spermatozoa; Time Factors; Titrimetry | 2007 |
Cell-permeant NAADP: a novel chemical tool enabling the study of Ca2+ signalling in intact cells.
Topics: Aniline Compounds; Animals; Biochemistry; Calcium; Calcium Signaling; Cell Membrane Permeability; Cells, Cultured; Drug Stability; Fluorescent Dyes; Guinea Pigs; Male; Molecular Biology; Molecular Structure; NADP; Neurons; Pharmacology; Rats; Rats, Wistar; Sea Urchins; Second Messenger Systems; Staining and Labeling; Xanthenes | 2008 |
Fertilization and nicotinic acid adenine dinucleotide phosphate induce pH changes in acidic Ca(2+) stores in sea urchin eggs.
Topics: Animals; Calcium; Calcium Signaling; Cytosol; Exocytosis; Female; Fertilization; Hydrogen-Ion Concentration; Male; NADP; Sea Urchins; Signal Transduction; Sodium; Sperm-Ovum Interactions; Spermatozoa | 2007 |
Generation of nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose by glucagon-like peptide-1 evokes Ca2+ signal that is essential for insulin secretion in mouse pancreatic islets.
Topics: Acetylcysteine; ADP-ribosyl Cyclase 1; Animals; Calcium; Cyclic ADP-Ribose; Endoplasmic Reticulum; Erythromycin; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred ICR; Mice, Knockout; NADP; Signal Transduction | 2008 |
Lysosomes co-localize with ryanodine receptor subtype 3 to form a trigger zone for calcium signalling by NAADP in rat pulmonary arterial smooth muscle.
Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Fluorescence; Heart; Lung; Lysosomes; Male; Muscle, Smooth, Vascular; NADP; Protein Isoforms; Pulmonary Artery; Rats; Rats, Wistar; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum | 2008 |
Sperm express a Ca2+-regulated NAADP synthase.
Topics: ADP-ribosyl Cyclase; Animals; Calcium; Male; NADP; Nucleotidyltransferases; Sea Urchins; Spermatozoa; Substrate Specificity | 2008 |
NAADP-induced Ca(2+ signaling in response to endothelin is via the receptor subtype B and requires the integrity of lipid rafts/caveolae.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; beta-Cyclodextrins; Calcium; Calcium Signaling; Caveolae; Caveolin 1; Cells, Cultured; Endothelin-1; Endothelins; Enzyme Inhibitors; Male; Membrane Glycoproteins; Membrane Microdomains; Myocytes, Smooth Muscle; NADP; Peptide Fragments; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Seminiferous Tubules; Signal Transduction | 2008 |
Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils.
Topics: Adenine Nucleotides; Animals; Calcium; Cells, Cultured; Cyclic ADP-Ribose; Humans; Hydrogen Peroxide; Intracellular Space; Ion Channel Gating; Mice; NADP; Neutrophils; Patch-Clamp Techniques; TRPM Cation Channels | 2008 |
Regulation of nuclear Ca2+ signaling by translocation of the Ca2+ messenger synthesizing enzyme ADP-ribosyl cyclase during neuronal depolarization.
Topics: Active Transport, Cell Nucleus; ADP-ribosyl Cyclase; Animals; Aplysia; Calcium; Calcium Channels, L-Type; Calcium Signaling; Cell Nucleus; Cyclic ADP-Ribose; Cytosol; Inositol 1,4,5-Trisphosphate; NADP; Neurons; Ryanodine Receptor Calcium Release Channel | 2008 |
TRP-ML1 functions as a lysosomal NAADP-sensitive Ca2+ release channel in coronary arterial myocytes.
Topics: Animals; Calcium; Calcium Channels; Cattle; Coronary Vessels; Fluorescence Resonance Energy Transfer; Gene Expression Regulation; Lysosomes; Microscopy, Fluorescence; Muscle Cells; NADP; RNA Interference; Signal Transduction; Transient Receptor Potential Channels; TRPM Cation Channels | 2009 |
Molecular characterization of a novel cell surface ADP-ribosyl cyclase from the sea urchin.
Topics: ADP-ribosyl Cyclase; Animals; Base Sequence; Cells, Cultured; Cyclic ADP-Ribose; Humans; Microscopy, Fluorescence; NADP; Oocytes; Sea Urchins; Transfection; Type C Phospholipases; Xenopus laevis | 2008 |
NAADP: a universal Ca2+ trigger.
Topics: ADP-ribosyl Cyclase 1; Animals; Calcium; Calcium Signaling; Humans; NADP | 2008 |
NAADP-mediated channel 'chatter' in neurons of the rat medulla oblongata.
Topics: Animals; Calcium; Cells, Cultured; Electrophysiology; Ion Channels; Medulla Oblongata; NADP; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley | 2009 |
Identification of a chemical probe for NAADP by virtual screening.
Topics: Animals; Carbolines; Cyclic ADP-Ribose; Inositol 1,4,5-Trisphosphate; Insulin-Secreting Cells; Mice; Models, Molecular; Molecular Structure; NADP; Ovum; Piperazines; Sea Urchins; Small Molecule Libraries | 2009 |
NAADP mobilizes calcium from acidic organelles through two-pore channels.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Cell Line; Chickens; Humans; Hydrogen-Ion Concentration; Insulin-Secreting Cells; Mice; Mice, Knockout; Molecular Sequence Data; NADP; Organelles; Protein Binding | 2009 |
NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arterioles.
Topics: ADP-ribosyl Cyclase; Animals; Arterioles; Calcium Signaling; Carbolines; Cytoplasmic Vesicles; Endothelin-1; Enzyme Inhibitors; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney; Macrolides; Microscopy, Fluorescence; Muscle, Smooth, Vascular; NADP; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Time Factors; Vacuolar Proton-Translocating ATPases | 2009 |
NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist.
Topics: Active Transport, Cell Nucleus; Animals; Binding, Competitive; Calcium; Calcium Signaling; Cell Nucleus; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Jurkat Cells; NADP; NFATC Transcription Factors; Niacin; Nicotinic Acids; Rats; Ryanodine; Ryanodine Receptor Calcium Release Channel; T-Lymphocytes; Tritium; Vitamin B Complex | 2009 |
Recruitment of NAADP-sensitive acidic Ca2+ stores by glutamate.
Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Female; Glutamic Acid; Hippocampus; In Vitro Techniques; Lysosomes; NADP; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2009 |
The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores.
Topics: Amino Acid Sequence; Animal Structures; Animals; Calcium; Calcium Channels; Calcium Signaling; Cell Line; Chlorocebus aethiops; Cloning, Molecular; COS Cells; Endoplasmic Reticulum; Enzyme Inhibitors; Glycosylation; Humans; Ion Channel Gating; Lysosomal-Associated Membrane Protein 1; Lysosomes; Mice; Mice, Inbred Strains; Molecular Sequence Data; NADP; Sequence Homology, Amino Acid; Thapsigargin; Transfection; Vacuolar Proton-Translocating ATPases | 2009 |
Second messenger signaling: multiple receptors for NAADP.
Topics: Calcium Channels; Cell Line; Humans; NADP; Receptors, Cell Surface; Ryanodine Receptor Calcium Release Channel; Second Messenger Systems | 2009 |
Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling.
Topics: Amino Acid Sequence; Animals; Calcium Channels; Calcium Signaling; Cells, Cultured; Endosomes; Humans; Lysosomes; Molecular Sequence Data; Mutation; NADP; Phylogeny; Sequence Alignment | 2009 |
Effects of hypoxia on testosterone release in rat Leydig cells.
Topics: 17-Hydroxysteroid Dehydrogenases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Hypoxia; Cell Separation; Cholesterol Side-Chain Cleavage Enzyme; Chorionic Gonadotropin; Colforsin; Cyclic AMP; Gonadotropins; Leydig Cells; Male; NADP; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Testosterone | 2009 |
Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor.
Topics: Animals; Binding Sites; Biological Assay; Calcium; Carbolines; Molecular Structure; NADP; Oocytes; Piperazines; Radioligand Assay; Receptors, Cell Surface; Sea Urchins | 2009 |
CD38-mediated Ca2+ signaling contributes to angiotensin II-induced activation of hepatic stellate cells: attenuation of hepatic fibrosis by CD38 ablation.
Topics: ADP-ribosyl Cyclase 1; Angiotensin II; Animals; Calcium; Calcium Signaling; Cell Proliferation; Collagen Type I; Cyclic ADP-Ribose; Extracellular Matrix Proteins; Gene Deletion; Hepatic Stellate Cells; Inositol 1,4,5-Trisphosphate; Intracellular Space; Liver Cirrhosis; Mice; Models, Biological; NADP | 2010 |
An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles.
Topics: Amino Acid Sequence; Animals; Calcium; Cloning, Molecular; Humans; Microscopy, Fluorescence; Molecular Sequence Data; NADP; Plasmids; Protein Isoforms; Pseudogenes; Sea Urchins; Sequence Homology, Amino Acid | 2010 |
Lysosome-dependent Ca(2+) release response to Fas activation in coronary arterial myocytes through NAADP: evidence from CD38 gene knockouts.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; ADP-ribosyl Cyclase 1; Animals; Calcium; Coronary Vessels; Fas Ligand Protein; fas Receptor; Female; Gene Expression Regulation; Lysosomes; Male; Membrane Glycoproteins; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADP; Vasoconstrictor Agents | 2010 |
Deviant nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated Ca2+ signaling upon lysosome proliferation.
Topics: Aging; Animals; Calcium; Calcium Signaling; Cathepsins; Glutamic Acid; Hippocampus; Lysosomes; NADP; Neurodegenerative Diseases; Neurons; PC12 Cells; Protease Inhibitors; Rats; Rats, Sprague-Dawley | 2010 |
A functional role for nicotinic acid adenine dinucleotide phosphate in oxytocin-mediated contraction of uterine smooth muscle from rat.
Topics: Animals; Calcium; Carbolines; Cells, Cultured; Female; In Vitro Techniques; Muscle, Smooth; Myocytes, Smooth Muscle; NADP; Organelles; Oxytocin; Piperazines; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum; Signal Transduction; Uterine Contraction | 2010 |
Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Endosomes; HEK293 Cells; Humans; Lysosomes; NADP; Protein Isoforms; Strongylocentrotus purpuratus | 2010 |
A single residue in a novel ADP-ribosyl cyclase controls production of the calcium-mobilizing messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate.
Topics: ADP-ribosyl Cyclase; Amino Acid Sequence; Animals; Blastomeres; Blotting, Western; Cell Line; Cloning, Molecular; Cyclic ADP-Ribose; Humans; Kinetics; Microinjections; Microscopy, Confocal; Molecular Sequence Data; Mutation; NADP; Sequence Homology, Amino Acid; Strongylocentrotus purpuratus; Transfection; Tyrosine; Xenopus laevis | 2010 |
The calcium-mobilizing messenger nicotinic acid adenine dinucleotide phosphate participates in sperm activation by mediating the acrosome reaction.
Topics: Acrosome; Acrosome Reaction; Animals; Calcium; Cations; Exocytosis; Female; Fura-2; Male; Manganese; NADP; Protein Binding; Sea Urchins; Signal Transduction; Spermatozoa | 2010 |
Generation of cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate by CD38 for Ca2+ signaling in interleukin-8-treated lymphokine-activated killer cells.
Topics: ADP-ribosyl Cyclase 1; Animals; Calcium; Calcium Signaling; Cell Movement; Cyclic ADP-Ribose; Humans; Interleukin-8; Killer Cells, Lymphokine-Activated; Mice; Mice, Transgenic; NADP; rap1 GTP-Binding Proteins; RNA, Small Interfering; Signal Transduction | 2010 |
Degeneration of an intracellular ion channel in the primate lineage by relaxation of selective constraints.
Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium Channels; Calcium Signaling; Codon, Nonsense; Computational Biology; Conserved Sequence; Evolution, Molecular; Gene Components; Gene Rearrangement; Humans; Likelihood Functions; Models, Genetic; Molecular Sequence Data; NADP; Phylogeny; Primates; Pseudogenes; Selection, Genetic | 2010 |
Calcium- and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADP.
Topics: Acids; Animals; Calcium; Cytoplasmic Granules; Magnetic Resonance Spectroscopy; Microscopy, Electron, Transmission; Microscopy, Fluorescence; NADP; Ovum; Polyphosphates; Sea Urchins | 2010 |
Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system.
Topics: Animals; Calcium Signaling; Cells, Cultured; Encephalomyelitis, Autoimmune, Experimental; NADP; Nicotinic Acids; Rats; Rats, Inbred Lew; T-Lymphocyte Subsets | 2010 |
TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle.
Topics: Animals; Calcium; Calcium Channels; Carbachol; Cell Membrane; Dose-Response Relationship, Drug; Gene Expression Profiling; Guinea Pigs; Inositol 1,4,5-Trisphosphate; Lysosomes; Male; Mice; Muscle Contraction; Muscle, Smooth; NADP | 2010 |
Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Cyclic ADP-Ribose; Humans; Hydrogen Peroxide; NAD; NADP; Oxidants; Oxidative Stress; TRPM Cation Channels; Xenopus laevis | 2010 |
Surface-enhanced Raman spectroscopy as a tool for detecting Ca2+ mobilizing second messengers in cell extracts.
Topics: Calcium; Calcium Signaling; Cell Line, Tumor; Cyclic ADP-Ribose; Gold; Humans; Inositol 1,4,5-Trisphosphate; Metal Nanoparticles; NADP; Second Messenger Systems; Spectrum Analysis, Raman | 2010 |
TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+.
Topics: Calcium; Calcium Channels; Carbolines; Cell Line; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion Concentration; Ion Channel Gating; Lysosomes; NADP; Piperazines; Protein Isoforms; Signal Transduction | 2010 |
The ecto-enzyme CD38 is a nicotinic acid adenine dinucleotide phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Calcium; Calcium Signaling; Cell Line; Cholagogues and Choleretics; Cholecystokinin; Lysosomes; Membrane Glycoproteins; Mice; Mice, Knockout; NADP; Nucleotidyltransferases; Pancreas, Exocrine; Rats | 2010 |
An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals.
Topics: Calcium; Calcium Channels; Calcium Signaling; Cell Line, Tumor; Cell Membrane; HEK293 Cells; Humans; Ion Channel Gating; Lysosomes; Mutation; NADP; Ryanodine Receptor Calcium Release Channel | 2010 |
Nicotinic acid adenine dinucleotide phosphate analogues containing substituted nicotinic acid: effect of modification on Ca(2+) release.
Topics: ADP-ribosyl Cyclase; Animals; Aplysia; Binding, Competitive; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; In Vitro Techniques; NAD+ Nucleosidase; NADP; Niacin; Radioligand Assay; Sea Urchins; Structure-Activity Relationship | 2010 |
Macrophage endoplasmic reticulum (ER) proteins and reducing elements stabilize paraoxonase 2 (PON2).
Topics: Animals; Aryldialkylphosphatase; Atherosclerosis; Cell Line; Dithiothreitol; Endoplasmic Reticulum; Enzyme Stability; Macrophages; Mice; NADP; Oxidation-Reduction; Recombinant Proteins; Subcellular Fractions | 2010 |
Nicotinic acid adenine dinucleotide phosphate regulates skeletal muscle differentiation via action at two-pore channels.
Topics: Acids; Animals; Calcium; Calcium Channels; Cell Differentiation; Cells, Cultured; Down-Regulation; Endoplasmic Reticulum; Inositol 1,4,5-Trisphosphate; Mice; Muscle, Skeletal; NADP; Ryanodine; Second Messenger Systems; Signal Transduction | 2010 |
NAADP as an intracellular messenger regulating lysosomal calcium-release channels.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Endosomes; Lysosomes; NADP | 2010 |
Monitoring the intracellular store Ca2+ concentration in agonist-stimulated, intact human platelets by using Fluo-5N.
Topics: Blood Platelets; Calcium; Calcium Signaling; Fluorescent Dyes; Fura-2; Humans; Hydroquinones; In Vitro Techniques; Inositol 1,4,5-Trisphosphate Receptors; Intracellular Fluid; Ionomycin; Microscopy, Confocal; NADP; Nigericin; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thapsigargin; Thrombin | 2011 |
Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation.
Topics: Calcium Signaling; Cell Line, Tumor; Female; Glycosylation; HEK293 Cells; Humans; Ion Channel Gating; Mutation; NADP; Protein Modification, Translational; Protein Structure, Secondary; Protein Structure, Tertiary; TRPC Cation Channels | 2011 |
Cyclic adenosine diphosphate ribose activates ryanodine receptors, whereas NAADP activates two-pore domain channels.
Topics: Calcium; Calcium Channels; Calcium Signaling; Cyclic ADP-Ribose; Endoplasmic Reticulum; HEK293 Cells; Humans; NADP | 2011 |
Critical role for CD38-mediated Ca2+ signaling in thrombin-induced procoagulant activity of mouse platelets and hemostasis.
Topics: ADP-ribosyl Cyclase 1; Animals; Blood Platelets; Calcium; Calcium Signaling; Cyclic ADP-Ribose; Enzyme Inhibitors; Hemostasis; Hemostatics; Inositol 1,4,5-Trisphosphate; Macrolides; Membrane Glycoproteins; Mice; Mice, Knockout; NADP; Phosphatidylserines; Protein Kinase C; Thrombin | 2011 |
NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endothelial cells.
Topics: Base Sequence; Calcium Channels; Calcium Signaling; Carbolines; Cell Line; Endothelial Cells; Gene Knockdown Techniques; Heptanoic Acids; Histamine; Humans; NADP; Nicotinic Antagonists; Piperazines; Piperidines; Receptors, Histamine H1; RNA, Small Interfering; Second Messenger Systems; von Willebrand Factor | 2011 |
Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels.
Topics: Amino Acid Substitution; Calcium; Calcium Channels; Endosomes; HEK293 Cells; HeLa Cells; Humans; Lysosomes; Mutation, Missense; NADP; Pancreas, Exocrine; Transient Receptor Potential Channels; TRPM Cation Channels | 2011 |
Acidic NAADP-releasable Ca(2+) compartments in the megakaryoblastic cell line MEG01.
Topics: Base Sequence; Calcium Channels; Calcium Signaling; Cell Compartmentation; Cell Line; Endoplasmic Reticulum; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Hydroquinones; Ionophores; Lysosomes; Macrolides; Megakaryocyte Progenitor Cells; NADP; Nigericin; RNA, Small Interfering; Vacuolar Proton-Translocating ATPases | 2011 |
Nicotinic acid adenine dinucleotide phosphate (NAADP) regulates autophagy in cultured astrocytes.
Topics: Animals; Apoptosis Regulatory Proteins; Astrocytes; Autophagy; Beclin-1; Calcium; Calcium Channels; Calcium Signaling; Cells, Cultured; Humans; NADP; Rats | 2011 |
Reconstitution of lysosomal NAADP-TRP-ML1 signaling pathway and its function in TRP-ML1(-/-) cells.
Topics: Calcium Signaling; Cell Line; Ceramides; Endocytosis; Endosomes; Fibroblasts; Humans; Lysosomes; Membrane Potentials; Microscopy, Confocal; Microscopy, Fluorescence; NADP; Recombinant Fusion Proteins; Time Factors; Transfection; Transient Receptor Potential Channels; TRPM Cation Channels | 2011 |
Intracellular angiotensin II activates rat myometrium.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Arsenicals; Autophagy; Brefeldin A; Calcium Signaling; Carbolines; Cells, Cultured; Egtazic Acid; Endocytosis; Endoplasmic Reticulum; Endosomes; Enzyme Inhibitors; Estrenes; Female; Heparin; Imidazoles; Inositol 1,4,5-Trisphosphate Receptors; Losartan; Lysosomes; Macrocyclic Compounds; Macrolides; Models, Biological; Myometrium; NADP; Oxazoles; Piperazines; Pyridines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Ryanodine; Saralasin; Signal Transduction; Sirolimus; Type C Phospholipases; Uterus | 2011 |
NAADP mediates ATP-induced Ca2+ signals in astrocytes.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Bradykinin; Calcium; Calcium Signaling; Cells, Cultured; Chelating Agents; Egtazic Acid; Endothelin-1; NADP; Rats; Rats, Sprague-Dawley | 2011 |
Two-pore channels form homo- and heterodimers.
Topics: Calcium; Calcium Channels; Endosomes; HEK293 Cells; Humans; NADP; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Tertiary | 2011 |
NAADP influences excitation-contraction coupling by releasing calcium from lysosomes in atrial myocytes.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Calcium; Cardiac Electrophysiology; Excitation Contraction Coupling; Guinea Pigs; Heart Atria; Lysosomes; Male; Myocardial Contraction; Myocytes, Cardiac; NADP; Sarcoplasmic Reticulum; Stimulation, Chemical | 2011 |
NAADP regulates human platelet function.
Topics: Blood Platelets; Calcium; Calcium Signaling; Carbolines; Carrier Proteins; Humans; NADP; Peptides; Piperazines; Platelet Activation; Receptor Protein-Tyrosine Kinases; Receptors, G-Protein-Coupled; Thrombin | 2012 |
Domain assembly of NAADP-gated two-pore channels.
Topics: Amino Acid Sequence; Cation Transport Proteins; Cell Membrane; Gene Expression Regulation; HEK293 Cells; Humans; Ion Channels; NADP; Protein Conformation; Protein Structure, Tertiary | 2012 |
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Endoplasmic Reticulum; HEK293 Cells; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Lysosomes; NADP; PC12 Cells; Proteasome Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Rats | 2012 |
CD38: a NAADP degrading enzyme.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase 1; Animals; Calcium; Gene Silencing; Humans; Jurkat Cells; Membrane Glycoproteins; Mice; Mice, Knockout; NADP; Spleen; Thymus Gland | 2011 |
Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells.
Topics: Animals; Binding Sites; Calcium Channels; Calcium Signaling; Cell Line, Tumor; HEK293 Cells; Humans; Ion Channel Gating; Mice; Mice, Knockout; NADP; Pancreas; Photoaffinity Labels | 2012 |
Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg.
Topics: Animals; Binding Sites; Calcium Channels; NADP; Ovum; Photoaffinity Labels; Protein Binding; Strongylocentrotus purpuratus | 2012 |
Arachidonic acid mobilizes Ca2+ from the endoplasmic reticulum and an acidic store in rat pancreatic β cells.
Topics: Adenosine; Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Calcium Channel Agonists; Calcium Signaling; Cells, Cultured; Endoplasmic Reticulum; Enzyme Inhibitors; Inositol 1,4,5-Trisphosphate Receptors; Insulin-Secreting Cells; Macrolides; Male; NADP; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Secretory Vesicles; Thapsigargin; TRPM Cation Channels | 2012 |
Triggering of Ca2+ signals by NAADP-gated two-pore channels: a role for membrane contact sites?
Topics: Animals; Calcium Channels; Calcium Signaling; Humans; Inositol 1,4,5-Trisphosphate Receptors; Intracellular Membranes; NADP; Ryanodine Receptor Calcium Release Channel | 2012 |
LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagy.
Topics: Animals; Autophagy; Calcium; Calcium Channels; Cell Survival; Drosophila melanogaster; Homeostasis; Lysosomes; Models, Biological; NADP; Phagosomes; Protein Serine-Threonine Kinases; Signal Transduction | 2012 |
Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1.
Topics: Biological Clocks; Calcium; Calcium Channels; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Lipid Bilayers; Membrane Potentials; NADP | 2012 |
Nicotinic acid adenine dinucleotide phosphate (NAADP) degradation by alkaline phosphatase.
Topics: ADP-ribosyl Cyclase 1; Alkaline Phosphatase; Cell Membrane; Gene Expression Regulation, Enzymologic; HEK293 Cells; HeLa Cells; Humans; Hydrogen-Ion Concentration; Isoenzymes; Jurkat Cells; Membrane Glycoproteins; NADP | 2012 |
β-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart.
Topics: Adrenergic beta-Agonists; Animals; Cyclic ADP-Ribose; Guinea Pigs; Heart; In Vitro Techniques; Myocardium; NADP; Receptors, Adrenergic, beta; Signal Transduction | 2012 |
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.
Topics: Animals; Calcium; Calcium Channels; Cell Line; Glucose; Insulin-Secreting Cells; Islets of Langerhans; Lysosomes; Mice; Mice, Knockout; NADP; Phosphatidylinositol Phosphates; Sodium Channels | 2012 |
The luminal Ca(2+) chelator, TPEN, inhibits NAADP-induced Ca(2+) release.
Topics: Animals; Calcium; Calcium Signaling; Chelating Agents; Ethylenediamines; Hydrogen-Ion Concentration; Inositol 1,4,5-Trisphosphate Receptors; NADP; Ovum; Sea Urchins | 2012 |
NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing.
Topics: Animals; Cytoplasmic Granules; Exocytosis; Humans; Inositol 1,4,5-Trisphosphate; Lymphocyte Activation; NADP; T-Lymphocytes, Cytotoxic | 2012 |
NAADP mediates insulin-stimulated glucose uptake and insulin sensitization by PPARγ in adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; ADP-ribosyl Cyclase 1; Animals; Glucose; Glucose Intolerance; Glucose Transporter Type 1; Glucose Transporter Type 4; Insulin; Membrane Glycoproteins; Mice; Mice, Inbred NOD; Mice, Knockout; NADP; Signal Transduction | 2012 |
Nicotinic acid adenine dinucleotide phosphate (NAADP) activates global and heterogeneous local Ca2+ signals from NAADP- and ryanodine receptor-gated Ca2+ stores in pulmonary arterial myocytes.
Topics: Animals; Calcium; Calcium Signaling; Carbolines; Endothelin-1; Gene Expression Regulation; Macrocyclic Compounds; Male; Myocytes, Smooth Muscle; NADP; Oxazoles; Piperazines; Pulmonary Artery; Rats; Rats, Wistar; Ryanodine; Ryanodine Receptor Calcium Release Channel | 2013 |
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger in muscarinic receptor-induced contraction of guinea pig trachea.
Topics: Animals; Calcium; Carbolines; Guinea Pigs; Muscle Contraction; Muscle, Smooth; NADP; Piperazines; Second Messenger Systems; Trachea | 2013 |
Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organelles.
Topics: Animals; Calcium; Calcium Signaling; Chelating Agents; Egtazic Acid; Endoplasmic Reticulum; Endosomes; Lysosomes; Lytechinus; NADP | 2013 |
Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation.
Topics: Adrenergic beta-Agonists; Animals; Arrhythmias, Cardiac; Calcium Signaling; Cells, Cultured; Isoproterenol; Mice; Myocardium; Myocytes, Cardiac; NADP; Nicotinic Acids; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum | 2013 |
Extracellular NAADP affords cardioprotection against ischemia and reperfusion injury and involves the P2Y11-like receptor.
Topics: Animals; Arrhythmias, Cardiac; Blotting, Western; Cardiotonic Agents; Cyclic AMP; Enzyme Activation; Inositol Phosphates; Myocardial Reperfusion Injury; NADP; Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2 | 2013 |
The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP.
Topics: Calcium Channels; Calcium Signaling; Endoplasmic Reticulum; Humans; NADP; Peptide Fragments | 2013 |
Determination of ADP-ribosyl cyclase activity, cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate in tissue extracts.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Chromatography, High Pressure Liquid; Cyclic ADP-Ribose; Fluorescence; Guanine Nucleotides; Humans; NAD; NAD+ Nucleosidase; NADP; Substrate Cycling; Tissue Extracts | 2013 |
Intracellular NAADP increase induced by extracellular NAADP via the P2Y11-like receptor.
Topics: ADP-ribosyl Cyclase; Animals; Animals, Newborn; Cells, Cultured; Cyclic ADP-Ribose; Cyclic AMP; Diphosphonates; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocytes, Cardiac; NADP; Naphthalenesulfonates; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Purinergic P2Y; Signal Transduction; Suramin; Time Factors | 2013 |
N-terminal tagging of two-pore channels interferes with NAADP action.
Topics: Calcium Channels; Calcium Signaling; Endoplasmic Reticulum; Humans; NADP | 2013 |
Two pore channel 2 differentially modulates neural differentiation of mouse embryonic stem cells.
Topics: Analysis of Variance; Animals; Blotting, Western; Calcium; Calcium Channels; Cell Differentiation; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; In Situ Nick-End Labeling; Mice; Microscopy, Fluorescence; NADP; Neurogenesis; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2013 |
Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH.
Topics: Alkalies; Animals; Autophagy; Calcium; Calcium Channels; Cell Differentiation; Embryonic Stem Cells; Endosomes; HeLa Cells; Humans; Hydrogen-Ion Concentration; Lysosomes; Membrane Fusion; Mice; NADP; Neurons; Phagosomes; Protein Binding; rab GTP-Binding Proteins; rab7 GTP-Binding Proteins; Signal Transduction; TOR Serine-Threonine Kinases | 2013 |
Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Autophagy; Calcium; Coronary Vessels; Dynactin Complex; Dyneins; Heat-Shock Proteins; Ketocholesterols; Lysosomes; Membrane Fusion; Mice; Microscopy, Confocal; Microtubule-Associated Proteins; Muscle Cells; NADP; Phagosomes; Sequestosome-1 Protein | 2013 |
Autocrine/paracrine function of nicotinic acid adenine dinucleotide phosphate (NAADP) for glucose homeostasis in pancreatic β-cells and adipocytes.
Topics: Adipocytes; Animals; Autocrine Communication; Biological Transport, Active; Calcium Signaling; Diabetes Mellitus, Type 2; Glucose; Homeostasis; Insulin; Insulin-Secreting Cells; Kinetics; Male; Mice; NADP; Paracrine Communication; Second Messenger Systems | 2013 |
Autophagy maturation associated with CD38-mediated regulation of lysosome function in mouse glomerular podocytes.
Topics: Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase 1; Animals; Autophagy; Calcium Signaling; Gene Silencing; Kidney Glomerulus; Lysosomes; Membrane Fusion; Mice; NADP; Phagosomes; Podocytes; Protein Transport; Proteolysis; Sirolimus; Transcription Factor TFIIH; Transcription Factors; Ubiquitinated Proteins | 2013 |
Two-pore channels (TPCs): current controversies.
Topics: Animals; Calcium; Calcium Channels; Humans; Lysosomes; NADP | 2014 |
Characterization of NAADP-mediated calcium signaling in human spermatozoa.
Topics: Calcium; Calcium Signaling; Cells, Cultured; Humans; Male; NADP; Spermatozoa | 2014 |
Activity of nicotinic acid substituted nicotinic acid adenine dinucleotide phosphate (NAADP) analogs in a human cell line: difference in specificity between human and sea urchin NAADP receptors.
Topics: Animals; Calcium; Calcium Signaling; Cell Line, Tumor; Fluorometry; Humans; NADP; Niacin; Nicotinic Acids; Ovum; Photolysis; Sea Urchins; Structure-Activity Relationship; Ultraviolet Rays | 2014 |
ZINClick: a database of 16 million novel, patentable, and readily synthesizable 1,4-disubstituted triazoles.
Topics: Alkynes; Azides; Click Chemistry; Databases, Pharmaceutical; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Models, Molecular; Molecular Conformation; NADP; Patents as Topic; Protein Kinase Inhibitors; Small Molecule Libraries; Triazoles | 2014 |
NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa.
Topics: Acrosome; Acrosome Reaction; Animals; Calcimycin; Calcium; Calcium Channels; Carbolines; Dose-Response Relationship, Drug; Female; Fertility; Gene Deletion; Gene Expression; Genotype; Heterozygote; Homozygote; Male; Mice; Mice, Knockout; NADP; Piperazines; Reproduction; Signal Transduction; Sperm Count | 2014 |
Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases.
Topics: Calcium; Calcium Channels; Cations, Divalent; Gene Expression Regulation, Enzymologic; Homeostasis; Magnesium; MAP Kinase Kinase 4; NADP; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositols | 2014 |
A computational model of lysosome-ER Ca2+ microdomains.
Topics: Calcium; Calcium Channels; Calcium Signaling; Endoplasmic Reticulum; Female; Humans; Lysosomes; Membrane Microdomains; Modems; NADP | 2014 |
How does NAADP release lysosomal Ca2+?
Topics: Animals; Biological Transport; Calcium; Humans; Lysosomes; NADP | 2014 |
Structural insight into glucose dehydrogenase from the thermoacidophilic archaeon Thermoplasma volcanium.
Topics: Base Sequence; Binding Sites; Crystallography, X-Ray; Glucose; Glucose 1-Dehydrogenase; Models, Molecular; Molecular Sequence Data; Mutation; NADP; Protein Conformation; Substrate Specificity; Sulfolobus solfataricus; Thermoplasma | 2014 |
Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+.
Topics: Calcium; Calcium Channels; Endosomes; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Ion Transport; Lysosomes; NADP; Permeability; Phosphatidylinositol Phosphates; Protons | 2014 |
NAADP-sensitive two-pore channels are present and functional in gastric smooth muscle cells.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Cell Line; Endoplasmic Reticulum; Endosomes; Lysosomes; Myocytes, Smooth Muscle; NADP; Rats; Recombinant Proteins; Stomach | 2014 |
CD38 mediates angiotensin II-induced intracellular Ca(2+) release in rat pulmonary arterial smooth muscle cells.
Topics: ADP-ribosyl Cyclase 1; Angiotensin II; Animals; Calcium; Calcium Channels; Male; Membrane Glycoproteins; Myocytes, Smooth Muscle; NADP; NADPH Oxidase 2; NADPH Oxidases; Protein Kinase C; Pulmonary Artery; Rats; Rats, Wistar; Reactive Oxygen Species; Ryanodine Receptor Calcium Release Channel; Vacuolar Proton-Translocating ATPases | 2015 |
The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation.
Topics: Animals; Calcium Channels; Calcium Signaling; Cell Proliferation; Chromatography, Affinity; Endosomes; HEK293 Cells; Humans; Lysosomes; NADP; Pigmentation; Protein Binding; Protein Isoforms; rab GTP-Binding Proteins; Reproducibility of Results; Xenopus | 2014 |
Preparation and use of sea urchin egg homogenates for studying NAADP-mediated Ca²⁺ release.
Topics: Adenosine Triphosphate; Aniline Compounds; Animals; Calcium; Calcium Signaling; Cell Fractionation; Female; Inositol 1,4,5-Trisphosphate; Male; NADP; Ovum; Sea Urchins; Xanthenes | 2014 |
Synthesis of [³²P]NAADP for the radioreceptor binding assay.
Topics: Binding Sites; Calcium; Carbon Isotopes; NADP; Radioligand Assay | 2014 |
Synthesis of NAADP-AM as a membrane-permeant NAADP analog.
Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Humans; NADP; Permeability | 2014 |
Measurement of luminal pH of acidic stores as a readout for NAADP action.
Topics: Acids; Animals; Hydrogen-Ion Concentration; Male; NADP; Organelles; Sea Urchins; Signal Transduction; Spermatozoa; Weights and Measures | 2014 |
Synthesis of caged NAADP.
Topics: Animals; Calcium; Calcium Signaling; NADP; Photochemistry; Photolysis | 2014 |
VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling.
Topics: Animals; Calcium Channels; Calcium Signaling; Carbolines; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Knockout; NADP; Neovascularization, Physiologic; Piperazines; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2014 |
Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes.
Topics: Calcium; Calcium Signaling; Carbachol; Cell Line; Humans; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Lysosomes; NADP | 2014 |
Two-pore channels function in calcium regulation in sea star oocytes and embryos.
Topics: ADP-ribosyl Cyclase; Animals; Calcium; Calcium Channels; Embryo, Nonmammalian; Fertilization; Immunoblotting; Immunohistochemistry; Immunoprecipitation; In Situ Hybridization; Mass Spectrometry; Microscopy, Electron, Transmission; Morpholinos; NADP; Oocytes; Starfish | 2014 |
Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.
Topics: Animals; Asparagine; Base Sequence; Calcium Channels; Calcium Channels, N-Type; Cations; Evolution, Molecular; Gene Duplication; Likelihood Functions; Models, Genetic; Molecular Docking Simulation; Molecular Sequence Data; NADP; Phylogeny; Sea Urchins; Sequence Analysis, DNA; Sequence Homology; Voltage-Gated Sodium Channels | 2014 |
Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition.
Topics: Calcium; Calcium Channels; Calcium Signaling; Fibroblasts; HEK293 Cells; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Lysosomes; NADP; Parkinson Disease; Primary Cell Culture; Protein Serine-Threonine Kinases | 2015 |
The role of calcium and nicotinic acid adenine dinucleotide phosphate (NAADP) in human osteoclast formation and resorption.
Topics: Bone Resorption; Calcium; Cell Differentiation; Humans; Macrophage Colony-Stimulating Factor; Monocytes; NADP; Osteoclasts; RANK Ligand | 2015 |
Determinants of the membrane orientation of a calcium signaling enzyme CD38.
Topics: ADP-ribosyl Cyclase 1; Calcium Signaling; Cell Membrane; HEK293 Cells; Humans; Membrane Glycoproteins; NADP; Phosphorylation; Protein Structure, Tertiary | 2015 |
Organelle-specific subunit interactions of the vertebrate two-pore channel family.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Chickens; Endoplasmic Reticulum; Endosomes; Gene Expression Regulation; HEK293 Cells; Humans; Lysosomes; Macrolides; NADP; Rabbits; Thapsigargin | 2015 |
A novel Ca²⁺-mediated cross-talk between endoplasmic reticulum and acidic organelles: implications for NAADP-dependent Ca²⁺ signalling.
Topics: Calcium; Calcium Signaling; Dipeptides; Endoplasmic Reticulum; Endosomes; HeLa Cells; Humans; Lysosomes; Macrolides; Membrane Potentials; NADP; Nigericin; Patch-Clamp Techniques; Thapsigargin; TRPM Cation Channels | 2015 |
Role of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) in Keratinocyte Differentiation.
Topics: Animals; Biological Transport; Calcium; Cell Differentiation; Cell Line; Cell Movement; Cell Proliferation; Gene Expression Regulation; Humans; Keratinocytes; Lysosomes; Macrolides; Mice; Microscopy, Video; NADP; Osmosis; Wound Healing | 2015 |
Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment.
Topics: Animals; Antiviral Agents; BALB 3T3 Cells; Benzylisoquinolines; Calcium Channel Blockers; Calcium Channels; Ebolavirus; Female; Gene Knockout Techniques; HeLa Cells; Hemorrhagic Fever, Ebola; Humans; Macrophages; Mice; Molecular Targeted Therapy; NADP; RNA Interference; Signal Transduction; Verapamil; Virus Internalization | 2015 |
Nicotinic Acid Adenine Dinucleotide Phosphate Analogues Substituted on the Nicotinic Acid and Adenine Ribosides. Effects on ReceptorMediated Ca²⁺ Release.
Topics: Animals; Calcium; Molecular Probes; NADP; Protein Binding; Proteins; Sea Urchins | 2015 |
Is hydrogen ion (H(+)) the real second messenger in calcium signalling?
Topics: Adenosine Triphosphate; Calcium Signaling; Cyclic AMP; Cytosol; Humans; Hydrogen-Ion Concentration; Inositol 1,4,5-Trisphosphate; Lysophospholipids; NADP; Second Messenger Systems; Sphingosine | 2015 |
Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Cells, Cultured; Evoked Potentials; Gene Expression; Hydrogen-Ion Concentration; Lysosomes; Mice; Mice, Knockout; NADP; Protein Isoforms; Signal Transduction | 2015 |
Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2'-phosphate.
Topics: Adenosine Diphosphate Ribose; Animals; Humans; Ion Channel Gating; NAD; NADP; Protein Binding; Pyrophosphatases; TRPM Cation Channels; Xenopus | 2015 |
Both RyRs and TPCs are required for NAADP-induced intracellular Ca²⁺ release.
Topics: Acinar Cells; Animals; Calcium; Calcium Channels; Calcium Signaling; Endoplasmic Reticulum; Endosomes; Lysosomes; Mice; Mice, Knockout; NADP; Pancreas, Exocrine; Ryanodine Receptor Calcium Release Channel | 2015 |
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.
Topics: Animals; Calcium; Calcium Channels; Cells, Cultured; Endosomes; Glucose; Insulin; Insulin-Secreting Cells; Male; Membrane Potentials; Mice; Mice, Knockout; NADP | 2015 |
Arginine Thiazolidine Carboxylate Stimulates Insulin Secretion through Production of Ca2+-Mobilizing Second Messengers NAADP and cADPR in Pancreatic Islets.
Topics: Animals; Arginine; Calcium; Calcium Signaling; Cyclic ADP-Ribose; Cyclic AMP; Cyclic GMP; Gene Expression; Glutathione; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred ICR; Mice, Knockout; NADP; Nitric Oxide; Nitric Oxide Synthase Type I; Prodrugs; Thiazolidines; Tissue Culture Techniques | 2015 |
Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore.
Topics: Animals; Calcium Channels; Calcium Signaling; Carbolines; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; NADP; Piperazines; Rats, Sprague-Dawley; Time Factors | 2015 |
Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart.
Topics: Animals; Calcium Channels; Guinea Pigs; Lysosomes; Male; Mice; Mice, Knockout; Myocardium; NADP; Receptors, Adrenergic, beta; Sarcoplasmic Reticulum; Signal Transduction | 2015 |
Frontrunners of T cell activation: Initial, localized Ca2+ signals mediated by NAADP and the type 1 ryanodine receptor.
Topics: Aniline Compounds; Animals; Benzofurans; Calcium; Calcium Signaling; Cells, Cultured; Fluorometry; Humans; Imidazoles; Jurkat Cells; Lymphocyte Activation; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; Muromonab-CD3; NADP; Ryanodine Receptor Calcium Release Channel; T-Lymphocytes; Time Factors; TRPM Cation Channels; Xanthenes | 2015 |
Nicotinic Acid Adenine Dinucleotide Phosphate Plays a Critical Role in Naive and Effector Murine T Cells but Not Natural Regulatory T Cells.
Topics: Absorption, Physicochemical; Animals; Antimetabolites; Calcium Signaling; Carbolines; Cell Proliferation; Cells, Cultured; Cytokines; Female; Immunity, Cellular; Immunity, Innate; Lymphocyte Activation; Mice, Inbred C57BL; Mice, Transgenic; NADP; Piperazines; Specific Pathogen-Free Organisms; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory | 2016 |
NAADP-Dependent Ca(2+) Signaling Controls Melanoma Progression, Metastatic Dissemination and Neoangiogenesis.
Topics: Animals; Calcium Signaling; Carbolines; Cell Adhesion; Cell Movement; Cell Proliferation; Cell Survival; Disease Models, Animal; Disease Progression; Gene Expression; Male; Melanoma; Melanoma, Experimental; Mice; NADP; Neoplasm Metastasis; Neovascularization, Pathologic; Piperazines; Tumor Burden; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2016 |
SIDT2 is involved in the NAADP-mediated release of calcium from insulin secretory granules.
Topics: ADP-ribosyl Cyclase 1; Animals; Calcium; Calcium Signaling; Gene Expression; Gene Expression Profiling; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Lysosomes; Membrane Proteins; Mice; Mice, Knockout; NADP; Nucleotide Transport Proteins; Protein Transport; Secretory Vesicles | 2016 |
Lysosomal cholesterol accumulation in macrophages leading to coronary atherosclerosis in CD38(-/-) mice.
Topics: Acids; ADP-ribosyl Cyclase 1; Animals; Atherosclerosis; Bone Marrow Cells; Cell Aggregation; Cholesterol; Coronary Vessels; Genotype; Lipid Metabolism; Lipoproteins, LDL; Lysosomes; Macrophages; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; NADP; Reproducibility of Results; Signal Transduction; Sterol Esterase | 2016 |
Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Cell Line; Chickens; Cyclic AMP-Dependent Protein Kinases; Electrophysiological Phenomena; Endoplasmic Reticulum; Gene Expression Regulation; HEK293 Cells; Humans; Lysosomes; Models, Biological; NADP; Nuclear Envelope; Patch-Clamp Techniques; Phosphorylation | 2016 |
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca2+ Signaling in Cardiac Hypertrophy Induced by β-Adrenergic Stimulation.
Topics: ADP-ribosyl Cyclase 1; Animals; Calcium Signaling; Cardiomegaly; Cyclic ADP-Ribose; Isoproterenol; Male; Mice, Knockout; Models, Biological; Myocytes, Cardiac; NADP; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Ultrasonography | 2016 |
Two-pore Channels Enter the Atomic Era: Structure of Plant TPC Revealed.
Topics: Arabidopsis; Arabidopsis Proteins; Binding Sites; Calcium; Calcium Channels; Calcium Signaling; Crystallography, X-Ray; Endosomes; Gene Expression; Ion Channel Gating; Lysosomes; NADP; Protein Binding; Protein Conformation, alpha-Helical; Protein Interaction Domains and Motifs; Vacuoles | 2016 |
Discrepancy in calcium release from the sarcoplasmic reticulum and intracellular acidic stores for the protection of the heart against ischemia/reperfusion injury.
Topics: Animals; Biomarkers; Calcium Signaling; Carbolines; Cardiac Pacing, Artificial; Coronary Vessels; Cyclic ADP-Ribose; Dantrolene; Heart; In Vitro Techniques; Ischemic Postconditioning; Lysosomes; Male; Muscle Relaxants, Central; Myocardial Reperfusion Injury; Myocardium; NADP; Piperazines; Rats, Wistar; Sarcoplasmic Reticulum | 2016 |
Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A.
Topics: Animals; Apoptosis; Autophagy; Calcium; Calcium Channels; Calcium Signaling; Cell Line, Tumor; Cell Survival; Cytosol; DNA; Endosomes; Green Fluorescent Proteins; HEK293 Cells; HeLa Cells; Humans; Iron; Iron Overload; Lysosomes; NADP; Neurodegenerative Diseases; Oxidative Stress; PC12 Cells; rab GTP-Binding Proteins; rab7 GTP-Binding Proteins; Rats | 2016 |
Integrated omics-analysis reveals Wnt-mediated NAD+ metabolic reprogramming in cancer stem-like cells.
Topics: ADP-ribosyl Cyclase 1; Alkaline Phosphatase; Calcium; Cell Line, Tumor; Cellular Reprogramming; Cytosol; Flow Cytometry; Gene Expression Profiling; Humans; In Situ Nick-End Labeling; Magnetic Resonance Spectroscopy; Mass Spectrometry; Membrane Glycoproteins; Metabolomics; NAD; NADP; Neoplastic Stem Cells; Spheroids, Cellular; Transcription Factor 4; Transfection; Wnt Signaling Pathway | 2016 |
cAMP-dependent recruitment of acidic organelles for Ca2+ signaling in the salivary gland.
Topics: Acids; Acinar Cells; Animals; Calcium; Calcium Channels; Calcium Signaling; Cyclic AMP; Endoplasmic Reticulum; Male; Mice; Mice, Inbred C57BL; NADP; Parotid Gland; Salivary Glands; Secretory Vesicles | 2016 |
3'-NADP and 3'-NAADP, Two Metabolites Formed by the Bacterial Type III Effector AvrRxo1.
Topics: Bacterial Proteins; NADP; Xanthomonas | 2016 |
Development of Ca2+-release mechanisms during oocyte maturation of the starfish Asterina pectinifera.
Topics: Adenine; Animals; Asterina; Calcium; Calcium Ionophores; Cytosol; Female; Fertilization in Vitro; Heparin; In Vitro Oocyte Maturation Techniques; Inositol 1,4,5-Trisphosphate; Ionomycin; Male; NADP; Oocytes; Sperm-Ovum Interactions | 2016 |
Glutamate induces autophagy via the two-pore channels in neural cells.
Topics: Astrocytes; Autophagy; Blotting, Western; Calcium Channels; Calcium Signaling; Cells, Cultured; Gene Knockdown Techniques; Glutamic Acid; Humans; Microscopy, Confocal; NADP; Neurons; Real-Time Polymerase Chain Reaction | 2017 |
High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart.
Topics: Animals; Biomarkers; Calcium; Calcium Channels; Calcium Signaling; Heart Ventricles; Lysosomal-Associated Membrane Protein 2; Lysosomes; Male; Myocytes, Cardiac; NADP; Organelles; Rabbits; Sarcoplasmic Reticulum | 2017 |
Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells.
Topics: Animals; Apoptosis; Benzylisoquinolines; Calcium; Calcium Channels; Carbolines; Cell Adhesion; Cell Movement; Cell Proliferation; Endosomes; Female; Lung Neoplasms; Lysosomes; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB C; NADP; Neoplasm Invasiveness; Piperazines; Tumor Cells, Cultured | 2017 |
An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Animals, Newborn; Antigens, CD; Avoidance Learning; Brain; Cyclic ADP-Ribose; GPI-Linked Proteins; HEK293 Cells; Humans; Immunohistochemistry; Male; Membrane Glycoproteins; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Models, Animal; NADP; Nestin; RNA, Messenger; Social Behavior | 2017 |
Liposomes as a Putative Tool to Investigate NAADP Signaling in Vasculogenesis.
Topics: Adult; Calcium Signaling; Carbolines; Cell Proliferation; Egtazic Acid; Endothelial Cells; Female; Humans; Liposomes; Male; NADP; Neovascularization, Physiologic; Piperazines | 2017 |
Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis.
Topics: Animals; Arabidopsis; Calcium Channels; Calcium Signaling; Flavanones; Human Umbilical Vein Endothelial Cells; Humans; Mice; NADP; Neovascularization, Physiologic; Vascular Endothelial Growth Factor A | 2017 |
Ned-19 inhibition of parasite growth and multiplication suggests a role for NAADP mediated signalling in the asexual development of Plasmodium falciparum.
Topics: Antimalarials; Carbolines; Erythrocytes; Humans; NADP; Piperazines; Plasmodium falciparum; Schizonts; Signal Transduction | 2017 |
NAADP-evoked Ca
Topics: Amino Acid Sequence; Arginine; Calcium Channels; Calcium Signaling; Cell Line; Humans; Mutation; NADP; Structure-Activity Relationship | 2017 |
CD38 produces nicotinic acid adenosine dinucleotide phosphate in the lysosome.
Topics: ADP-ribosyl Cyclase 1; Calcium; Calcium Signaling; Endocytosis; HEK293 Cells; HeLa Cells; Humans; Lysosomes; Membrane Glycoproteins; NADP; Niacin; Single-Domain Antibodies; Vasodilator Agents | 2018 |
mTORC1 controls lysosomal Ca
Topics: Animals; Calcium; Calcium Channels; Cells, Cultured; HEK293 Cells; Humans; Lysosomes; Male; Mechanistic Target of Rapamycin Complex 1; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Smooth Muscle; NADP; Pulmonary Artery; Rats, Wistar; Signal Transduction; Sirolimus | 2018 |
Gordon Research Conference on Ca
Topics: Calcium; Calcium Signaling; NADP | 2018 |
NAADP-dependent Ca
Topics: Benzylisoquinolines; Calcium Signaling; Cell Line; Endosomes; Furin; Gene Knockdown Techniques; Humans; Ion Channels; Lysosomes; Middle East Respiratory Syndrome Coronavirus; NADP; Reproducibility of Results; Spike Glycoprotein, Coronavirus; Voltage-Gated Sodium Channels | 2018 |
A screening campaign in sea urchin egg homogenate as a platform for discovering modulators of NAADP-dependent Ca
Topics: Animals; Calcium; Calcium Signaling; Cell Line; Drug Evaluation, Preclinical; Humans; Lysosomes; NADP; Ovum; Reproducibility of Results; Sea Urchins | 2018 |
The Hydrophobin HYTLO1 Secreted by the Biocontrol Fungus
Topics: Aequorin; Biological Control Agents; Calcium; Calcium Signaling; Cloning, Molecular; Fungal Proteins; Genes, Reporter; Host Microbial Interactions; Lotus; Mitogen-Activated Protein Kinase Kinases; NADP; Plant Proteins; Plants, Genetically Modified; Trichoderma | 2018 |
Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Cells, Cultured; Hippocampus; Long-Term Potentiation; Male; Mice; Mice, Knockout; NADP; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 2018 |
5-Azido-8-ethynyl-NAADP: A bifunctional, clickable photoaffinity probe for the identification of NAADP receptors.
Topics: Animals; Calcium Signaling; Cell Line, Tumor; Fluorescent Dyes; Humans; NADP; Sea Urchins; Staining and Labeling; Ultraviolet Rays | 2019 |
Role of NAADP for calcium signaling in the salivary gland.
Topics: Acinar Cells; Animals; Calcium Signaling; Cells, Cultured; Humans; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Molecular Targeted Therapy; NADP; Pancreas; Patch-Clamp Techniques; Salivary Glands; Xerostomia | 2019 |
The synthesis and characterization of a clickable-photoactive NAADP analog active in human cells.
Topics: Animals; Benzoic Acid; Binding Sites; Calcium; Calcium Signaling; Cell Line, Tumor; Click Chemistry; Humans; NADP; Photoaffinity Labels; Protein Binding; Sea Urchins | 2019 |
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function.
Topics: Animals; Benzylisoquinolines; Calcium; Calcium Channel Agonists; Calcium Channels; Fluphenazine; Gene Expression Regulation; HEK293 Cells; HeLa Cells; Humans; Ionomycin; Macrophages; Mice; NADP; Phosphatidylinositol Phosphates; Raloxifene Hydrochloride; Single Molecule Imaging; Sodium | 2020 |
NAADP-regulated two-pore channels drive phagocytosis through endo-lysosomal Ca
Topics: Animals; Calcineurin; Dynamin II; Endosomes; Lysosomes; Macrophages; Mice; Mice, Knockout; NADP; Phagocytosis | 2020 |
Nicotinic acid adenine dinucleotide phosphate activates two-pore channel TPC1 to mediate lysosomal Ca
Topics: Calcium; Calcium Channels; Calcium Signaling; Cell Line; Endoplasmic Reticulum; Endothelial Cells; Humans; Lysosomes; NADP; Vascular Endothelial Growth Factor A | 2021 |
Interleukin-8 drives CD38 to form NAADP from NADP
Topics: ADP-ribosyl Cyclase 1; Animals; Calcium Signaling; Cell Movement; Cells, Cultured; Interleukin-8; Killer Cells, Lymphokine-Activated; Lysosomes; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; NADP | 2020 |
Unconventional role of lysosomes in phagocytosis.
Topics: Animals; Calcineurin; Calcium; Humans; Lysosomes; NADP; Phagocytosis; Phagosomes | 2020 |
Chemo-enzymatic synthesis of adenine substituted nicotinic acid adenine dinucleotide phosphate (NAADP) analogs.
Topics: Adenine; Animals; Calcium; Dose-Response Relationship, Drug; Humans; Molecular Structure; NADP; Phosphotransferases (Alcohol Group Acceptor); Sea Urchins; Structure-Activity Relationship | 2021 |
Essential requirement for JPT2 in NAADP-evoked Ca
Topics: Affinity Labels; Animals; Calcium Channels; Calcium Signaling; Carrier Proteins; Click Chemistry; COVID-19; Gene Knockdown Techniques; HEK293 Cells; Humans; Microtubule-Associated Proteins; NADP; Recombinant Proteins; SARS-CoV-2; Second Messenger Systems; Transcriptome; Virus Internalization | 2021 |
A NOVEL NOX/PHOX-CD38-NAADP-TFEB AXIS IMPORTANT FOR MACROPHAGE ACTIVATION DURING BACTERIAL PHAGOCYTOSIS.
Topics: Autophagy; Bacteria; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Macrophage Activation; NADP; Phagocytosis; Reactive Oxygen Species | 2022 |
Glucose and NAADP trigger elementary intracellular β-cell Ca
Topics: Animals; Calcium; Calcium Signaling; Glucose; Insulin-Secreting Cells; Male; Mice; NADP | 2021 |
LRRK2 is required for CD38-mediated NAADP-Ca
Topics: Adenosine Diphosphate Ribose; Antibodies, Monoclonal; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Calcium; Humans; Leucine; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Lipopolysaccharides; Lysosomes; NADP; Parkinson Disease; Transcription Factors | 2022 |
Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles.
Topics: Animals; Calcium; Calcium Channels; Cell Line; Circadian Rhythm Signaling Peptides and Proteins; Endosomes; Fibroblasts; HEK293 Cells; Humans; Lysosomes; Mice; Mutation; NADP; Porins; Proteomics | 2021 |
NAADP receptors: A one-two.
Topics: Calcium; Calcium Channels; Calcium Signaling; NADP | 2021 |
Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca
Topics: Animals; Calcium Signaling; Dual Oxidases; HEK293 Cells; Humans; Jurkat Cells; Lymphocyte Activation; Mice, Knockout; NADP; NADPH Oxidases; T-Lymphocytes | 2021 |
Trans-Ned 19-Mediated Antagonism of Nicotinic Acid Adenine Nucleotide-Mediated Calcium Signaling Regulates Th17 Cell Plasticity in Mice.
Topics: Animals; Calcium; Calcium Signaling; Carbolines; CD3 Complex; Cell Differentiation; Cell Plasticity; Cell Proliferation; Disease Models, Animal; Forkhead Transcription Factors; Inflammation; Interleukin-10; Intestines; Lymphocyte Activation; Mice, Inbred C57BL; Mice, Transgenic; NADP; Piperazines; Receptors, Antigen, T-Cell; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells; Up-Regulation | 2021 |
NAADP Signaling: New Kids on the Block.
Topics: Calcium; Calcium Signaling; Carrier Proteins; NADP; Second Messenger Systems | 2022 |
Identification of ASPDH as a novel NAADP-binding protein.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Carboxy-Lyases; Carrier Proteins; Mice; NADP; Swine | 2022 |
NAADP-Dependent TPC Current.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Humans; Lysosomes; Mammals; NADP; Signal Transduction | 2023 |
PI(3,5)P
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Lysosomes; Mammals; NADP | 2023 |
NAADP-Evoked Ca
Topics: Animals; Astrocytes; Autophagy; Calcium; Calcium Channels; Huntingtin Protein; Lysosomes; Mice; NADP; Neurodegenerative Diseases | 2023 |
Determination of the roles of cADPR and NAADP as intracellular calcium mobilizing messengers in S1P-induced contractions in rat bladders having IC/PBS.
Topics: Animals; Calcium; Calcium, Dietary; Cyclic ADP-Ribose; Cystitis; Cystitis, Interstitial; Muscle Contraction; NADP; Rats | 2023 |
Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12.
Topics: Carrier Proteins; Coronavirus Infections; Endosomes; Humans; NADP | 2023 |