n6022 and propionic-acid

n6022 has been researched along with propionic-acid* in 1 studies

Other Studies

1 other study(ies) available for n6022 and propionic-acid

ArticleYear
Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement.
    Bioorganic & medicinal chemistry letters, 2011, Jun-15, Volume: 21, Issue:12

    S-Nitrosoglutathione reductase (GSNOR) is a member of the alcohol dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO). GSNO and SNOs are implicated in the pathogenesis of many diseases including those in respiratory, cardiovascular, and gastrointestinal systems. The pyrrole based N6022 was recently identified as a potent, selective, reversible, and efficacious GSNOR inhibitor which is currently undergoing clinical development. We describe here the synthesis and structure-activity relationships (SAR) of novel pyrrole based analogues of N6022 focusing on scaffold modification and propionic acid replacement. We identified equally potent and novel GSNOR inhibitors having pyrrole regioisomers as scaffolds using a structure based approach.

    Topics: Aldehyde Oxidoreductases; Benzamides; Enzyme Activation; Enzyme Inhibitors; Inhibitory Concentration 50; Molecular Structure; Propionates; Pyrroles; Stereoisomerism; Structure-Activity Relationship

2011