Compounds > n-succinimidyl-4-fluorobenzoate

n-succinimidyl-4-fluorobenzoate and epsilon-(gamma-glutamyl)-lysine

n-succinimidyl-4-fluorobenzoate has been researched along with epsilon-(gamma-glutamyl)-lysine* in 1 studies

Other Studies

1 other study(ies) available for n-succinimidyl-4-fluorobenzoate and epsilon-(gamma-glutamyl)-lysine

Article	Year
Radiolabelling of isopeptide N epsilon-(gamma-glutamyl)-L-lysine by conjugation with N-succinimidyl-4-[18F]fluorobenzoate. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2003, Volume: 59, Issue:1 The isopeptide N(epsilon)-(gamma-glutamyl)-L-lysine 4 was labelled with 18F via N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB). A modified approach for the convenient synthesis of [18F]SFB was used, and [18F]SFB could be obtained in decay-corrected radiochemical yields of 44-53% (n = 20) and radiochemical purity >95% within 40 min after EOB. For labelling N(epsilon)-(gamma-glutamyl)-L-lysine with [18F]SFB the effects of isopeptide concentration, temperature, and pH were studied to determine the optimum reaction conditions. The coupling reaction was shown to be temperature and pH independent while being strongly affected by the isopeptide concentration. Using the optimized labelling conditions, in a typical experiment 1.3GBq of [18F]SFB could be converted into 447MBq (46%, decay-corrected) of [18F]fluorobenzoylated isopeptide within 45 min, including HPLC purification. Topics: Benzoates; Biomarkers; Dipeptides; Fluorine Radioisotopes; Hydrogen-Ion Concentration; Isotope Labeling; Radioactivity; Radiochemistry; Stereoisomerism; Succinimides; Temperature	2003

Article

Year

Radiolabelling of isopeptide N epsilon-(gamma-glutamyl)-L-lysine by conjugation with N-succinimidyl-4-[18F]fluorobenzoate.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2003, Volume: 59, Issue:1

The isopeptide N(epsilon)-(gamma-glutamyl)-L-lysine 4 was labelled with 18F via N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB). A modified approach for the convenient synthesis of [18F]SFB was used, and [18F]SFB could be obtained in decay-corrected radiochemical yields of 44-53% (n = 20) and radiochemical purity >95% within 40 min after EOB. For labelling N(epsilon)-(gamma-glutamyl)-L-lysine with [18F]SFB the effects of isopeptide concentration, temperature, and pH were studied to determine the optimum reaction conditions. The coupling reaction was shown to be temperature and pH independent while being strongly affected by the isopeptide concentration. Using the optimized labelling conditions, in a typical experiment 1.3GBq of [18F]SFB could be converted into 447MBq (46%, decay-corrected) of [18F]fluorobenzoylated isopeptide within 45 min, including HPLC purification.

Topics: Benzoates; Biomarkers; Dipeptides; Fluorine Radioisotopes; Hydrogen-Ion Concentration; Isotope Labeling; Radioactivity; Radiochemistry; Stereoisomerism; Succinimides; Temperature

2003