Compounds > n-pentanol
Page last updated: 2024-08-17

n-pentanol and benzofurans

n-pentanol has been researched along with benzofurans in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (13.33)29.6817
2010's13 (86.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Asadullah, K; Döcke, WD; Jaroch, S; May, E; Neuhaus, R; Rehwinkel, H; Schäcke, H; Skuballa, W; Zollner, TM; Zügel, U1
Cavet, ME; DeWitt, CA; López, FJ; Pfeffer, BA; Salvador-Silva, M; Ward, KW1
Cavet, ME; López, FJ; Salvador-Silva, M; VanderMeid, KR; Ward, KW; Zhang, JZ1
Cavet, ME; Harrington, KL; Ward, KW; Zhang, JZ1
Bucolo, C; Budzynski, E; López, FJ; Shafiee, A; Ward, KW1
Lowe, ER; Proksch, JW; Ward, KW1
Clark, AR; Ding, Q; Gong, L; Joanny, E; Kong, P; Saklatvala, J1
Baiula, M; Bedini, A; Bucolo, C; Carbonari, G; Govoni, P; Spampinato, S; Spartà, A; Ward, KW; Zhang, JZ1
Stockhausen, A; Vollmer, TR; Zhang, JZ1
Cavet, ME; Harrington, KL; Volhejn, S; Zhang, JZ1
Baiula, M; Baldi, J; Bedini, A; Cavet, ME; Govoni, P; Spampinato, S1
Cavet, ME; Feldon, SE; McMillan, DH; Phipps, RP; Richardson, ME; Spinelli, SL; Woeller, CF; Xi, X; Zhang, JZ1
Baiula, M; Spampinato, S1
Bäumer, W; Rossbach, K; Schmidt, BH1
Grossmann, U; Hoffman-Wecker, M; Nkulikiyinka, R; Shakery, K; Staedtler, G; von Mackensen, YL; Wigger-Alberti, W; Williams, R1

Reviews

1 review(s) available for n-pentanol and benzofurans

ArticleYear
Mapracorat, a novel non-steroidal selective glucocorticoid receptor agonist for the treatment of allergic conjunctivitis.
    Inflammation & allergy drug targets, 2014, Volume: 13, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Clinical Trials, Phase II as Topic; Conjunctivitis, Allergic; Cytokines; Dexamethasone; Eosinophils; Humans; Models, Animal; Pentanols; Quinolines; Receptors, Glucocorticoid; Transcriptional Activation

2014

Trials

1 trial(s) available for n-pentanol and benzofurans

ArticleYear
Comparison of Occlusive and Open Application in a Psoriasis Plaque Test Design, Exemplarily Using Investigations of Mapracorat 0.1% Ointment versus Vehicle and Reference Drugs.
    Skin pharmacology and physiology, 2017, Volume: 30, Issue:2

    Topics: Adult; Aged; Benzofurans; Dermatologic Agents; Double-Blind Method; Drug Design; Female; Humans; Male; Middle Aged; Models, Biological; Ointments; Pentanols; Psoriasis; Quinolines; Research Design; Treatment Outcome

2017

Other Studies

13 other study(ies) available for n-pentanol and benzofurans

ArticleYear
Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases.
    British journal of pharmacology, 2009, Volume: 158, Issue:4

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Benzofurans; Drug Evaluation, Preclinical; Inflammation; Mice; Mice, Inbred Strains; Pentanols; Quinolines; Rats; Rats, Wistar; Receptors, Glucocorticoid; Sensitivity and Specificity; Skin; Skin Diseases

2009
Reduced myocilin expression in cultured monkey trabecular meshwork cells induced by a selective glucocorticoid receptor agonist: comparison with steroids.
    Investigative ophthalmology & visual science, 2010, Volume: 51, Issue:1

    Topics: Animals; Benzofurans; Blotting, Western; Cells, Cultured; Cytoskeletal Proteins; Dexamethasone; Dose-Response Relationship, Drug; Eye Proteins; Gene Expression; Glucocorticoids; Glycoproteins; Hormone Antagonists; Macaca mulatta; Mifepristone; Pentanols; Prednisolone; Quinolines; Receptors, Glucocorticoid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trabecular Meshwork

2010
BOL-303242-X, a novel selective glucocorticoid receptor agonist, with full anti-inflammatory properties in human ocular cells.
    Molecular vision, 2009, Dec-08, Volume: 15

    Topics: Anti-Inflammatory Agents; Astrocytes; Benzofurans; Cell Extracts; Cells, Cultured; Conjunctiva; Dexamethasone; Endothelial Cells; Epithelial Cells; Epithelium, Corneal; Eye; Fibroblasts; Humans; I-kappa B Proteins; Intercellular Adhesion Molecule-1; Interleukin-1beta; Lipopolysaccharides; Mitogen-Activated Protein Kinases; NF-kappa B; Optic Nerve; Pentanols; Phosphorylation; Quinolines; Receptors, Glucocorticoid; Triamcinolone Acetonide

2009
Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cells.
    Molecular vision, 2010, Sep-02, Volume: 16

    Topics: Benzofurans; Cell Line; Cytokines; Dexamethasone; Enzyme Activation; Epithelial Cells; Epithelium, Corneal; Humans; MAP Kinase Signaling System; Mifepristone; Mitogen-Activated Protein Kinases; NF-kappa B; Osmolar Concentration; Pentanols; Phosphorylation; Quinolines; Receptors, Glucocorticoid; Transcription Factor AP-1

2010
In vivo ocular efficacy profile of mapracorat, a novel selective glucocorticoid receptor agonist, in rabbit models of ocular disease.
    Investigative ophthalmology & visual science, 2011, Mar-14, Volume: 52, Issue:3

    Topics: Administration, Topical; Animals; Aqueous Humor; Benzofurans; Body Weight; Dexamethasone; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Dry Eye Syndromes; Female; Glucocorticoids; Intraocular Pressure; Pentanols; Quinolines; Rabbits; Receptors, Glucocorticoid; Tears; Treatment Outcome

2011
Ocular pharmacokinetics of mapracorat, a novel, selective glucocorticoid receptor agonist, in rabbits and monkeys.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7

    Topics: Animals; Benzofurans; Chromatography, Liquid; Dexamethasone; Dose-Response Relationship, Drug; Eye; Female; Macaca fascicularis; Male; Pentanols; Prednisolone; Quinolines; Rabbits; Receptors, Glucocorticoid; Tandem Mass Spectrometry

2011
Anti-inflammatory effects of selective glucocorticoid receptor modulators are partially dependent on up-regulation of dual specificity phosphatase 1.
    British journal of pharmacology, 2012, Volume: 165, Issue:4b

    Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Benzoxazines; Bone Marrow Cells; Cell Line; Cell Line, Tumor; Cyclooxygenase 2; Cytokines; Dexamethasone; Dual Specificity Phosphatase 1; Glucocorticoids; HeLa Cells; Humans; Macrophages; Mice; Mice, Knockout; NF-kappa B; Pentanols; Quinolines; Receptors, Glucocorticoid; RNA, Messenger

2012
Eosinophil as a cellular target of the ocular anti-allergic action of mapracorat, a novel selective glucocorticoid receptor agonist.
    Molecular vision, 2011, Volume: 17

    Topics: Administration, Ophthalmic; Animals; Annexin A1; Anti-Allergic Agents; Apoptosis; Benzofurans; Blotting, Western; Caspase 3; Cells, Cultured; Conjunctiva; Conjunctivitis, Allergic; Cytokines; Dexamethasone; Eosinophils; Flow Cytometry; Guinea Pigs; Humans; Male; Mifepristone; Ophthalmic Solutions; Ovalbumin; Pentanols; Quinolines; Receptors, Glucocorticoid

2011
Anti-inflammatory effects of mapracorat, a novel selective glucocorticoid receptor agonist, is partially mediated by MAP kinase phosphatase-1 (MKP-1).
    The Journal of biological chemistry, 2012, Oct-12, Volume: 287, Issue:42

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Benzofurans; Cell Line; Dexamethasone; Diterpenes; Dose-Response Relationship, Drug; Dual Specificity Phosphatase 1; Epoxy Compounds; Gene Expression Regulation, Enzymologic; Granulocyte-Macrophage Colony-Stimulating Factor; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Macrophages; Mice; p38 Mitogen-Activated Protein Kinases; Pentanols; Phenanthrenes; Protein Serine-Threonine Kinases; Quinolines; Receptors, Glucocorticoid; Tumor Necrosis Factor-alpha

2012
Anti-allergic effects of mapracorat, a novel selective glucocorticoid receptor agonist, in human conjunctival fibroblasts and epithelial cells.
    Molecular vision, 2013, Volume: 19

    Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Benzofurans; Cattle; Conjunctiva; Epithelial Cells; Fibroblasts; Gene Silencing; Humans; Hypersensitivity; Intercellular Adhesion Molecule-1; Interleukin-13; Interleukin-4; Pentanols; Quinolines; Receptors, Glucocorticoid; Tumor Necrosis Factor-alpha

2013
Mapracorat, a selective glucocorticoid receptor agonist, causes apoptosis of eosinophils infiltrating the conjunctiva in late-phase experimental ocular allergy.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Animals; Apoptosis; Benzofurans; Conjunctiva; Conjunctivitis, Allergic; Eosinophils; Guinea Pigs; Humans; Male; Molecular Conformation; Pentanols; Quinolines; Receptors, Glucocorticoid; Structure-Activity Relationship

2014
Mapracorat, a selective glucocorticoid receptor agonist, upregulates RelB, an anti-inflammatory nuclear factor-kappaB protein, in human ocular cells.
    Experimental eye research, 2014, Volume: 127

    Topics: Anti-Inflammatory Agents; Benzofurans; Blotting, Western; Cells, Cultured; Corneal Keratocytes; Cytokines; Dexamethasone; Enzyme-Linked Immunosorbent Assay; Glucocorticoids; Humans; NF-kappa B; Pentanols; Quinolines; Receptors, Glucocorticoid; Transcription Factor RelA; Transcription Factor RelB; Up-Regulation

2014
The selective glucocorticoid receptor agonist mapracorat displays a favourable safety-efficacy ratio for the topical treatment of inflammatory skin diseases in dogs.
    Veterinary dermatology, 2017, Volume: 28, Issue:1

    Topics: Administration, Topical; Animals; Benzofurans; Dermatitis; Dermatologic Agents; Dog Diseases; Dogs; Female; Male; Pentanols; Quinolines; Receptors, Glucocorticoid; Treatment Outcome; Triamcinolone Acetonide; Tumor Necrosis Factor-alpha

2017