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n,n,n'-trimethyl-n'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine and acetazolamide

n,n,n'-trimethyl-n'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine has been researched along with acetazolamide in 2 studies

*Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337) [MeSH]

*Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337) [MeSH]

Compound Research Comparison

Studies
(n,n,n'-trimethyl-n'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine)
Trials
(n,n,n'-trimethyl-n'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine)
Recent Studies (post-2010)
(n,n,n'-trimethyl-n'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine)
Studies
(acetazolamide)
Trials
(acetazolamide)
Recent Studies (post-2010) (acetazolamide)
80217,6044951,521

Protein Interaction Comparison

ProteinTaxonomyn,n,n'-trimethyl-n'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine (IC50)acetazolamide (IC50)
Chain A, Class Iii Chitinase Chia1Aspergillus fumigatus A1163164
Carbonic anhydrase 12Homo sapiens (human)0.3178
ReninHomo sapiens (human)8.2
Carbonic anhydrase 1Homo sapiens (human)2.3173
Carbonic anhydrase 2Homo sapiens (human)1.2619
Carbonic anhydrase 2Bos taurus (cattle)0.7
Carbonic anhydrase 3Homo sapiens (human)1.95
Cathepsin BBos taurus (cattle)0.02
Steryl-sulfataseHomo sapiens (human)0.025
Carbonic anhydrase 4Homo sapiens (human)0.1216
Carbonic anhydrase 6Homo sapiens (human)0.2925
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)0.1763
Carbonic anhydrase 7Homo sapiens (human)1.1737
Carbonic anhydrase 9Homo sapiens (human)0.464
ReninMacaca mulatta (Rhesus monkey)8.2
Carbonic anhydrase 13Homo sapiens (human)0.23
Carbonic anhydrase 4Bos taurus (cattle)0.07
Carbonic anhydrase 13Mus musculus (house mouse)0.77
Carbonic anhydrase 14Homo sapiens (human)0.183
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)0.23

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19901 (50.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Devous, MD; Lowe, JL; Payne, JK1
Burt, RW; Mock, BM; Reddy, RV; Schauwecker, DS; Wellman, HN; Witt, R1

Other Studies

2 other study(ies) available for n,n,n'-trimethyl-n'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine and acetazolamide

ArticleYear
Dual-isotope brain SPECT imaging with technetium-99m and iodine-123: clinical validation using xenon-133 SPECT.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1992, Volume: 33, Issue:11

    Topics: Acetazolamide; Adult; Brain; Cerebrovascular Circulation; Cerebrovascular Disorders; Female; Humans; Iodine Radioisotopes; Iodobenzenes; Male; Middle Aged; Organotechnetium Compounds; Oximes; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon; Vasodilation; Xenon Radioisotopes

1992
Acetazolamide enhancement of HIPDM brain flow distribution imaging.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1986, Volume: 27, Issue:10

    Topics: Acetazolamide; Cerebrovascular Circulation; Cerebrovascular Disorders; Humans; Iodobenzenes; Tomography, Emission-Computed; Xenon Radioisotopes

1986