n-n-dimethylpradimicin-fa-2 and castanospermine

n-n-dimethylpradimicin-fa-2 has been researched along with castanospermine* in 1 studies

Other Studies

1 other study(ies) available for n-n-dimethylpradimicin-fa-2 and castanospermine

Article	Year
High-mannose type oligosaccharide-dependent apoptosis in U937 cells induced by pradimicin, a mannose-binding antibiotic. The Journal of antibiotics, 1999, Volume: 52, Issue:5 Cell surface oligosaccharides play a role in a variety of biological events such as cell adhesion and signal transduction. We have shown that BMY-28864, a semi-synthetic analog of pradimicin, induced apoptosis of U937 cells which had been incubated with 1-deoxymannojirimycin, an inhibitor of mannosidase I. BMY-28864 was not cytotoxic to the cells which had been cultivated with other glycosidase inhibitors such as castanospermine and swainsonine. We thus propose that BMY-28864 induces apoptosis by acting on a specific mannose-rich oligosaccharide, presumably (Man)9(GlcNAc)2+. Topics: 1-Deoxynojirimycin; Anthracyclines; Antibiotics, Antineoplastic; Antifungal Agents; Apoptosis; Enzyme Inhibitors; Fluorescein-5-isothiocyanate; Glucosidases; Humans; Indolizines; Mannose; Mannosidases; Oligosaccharides; Swainsonine; U937 Cells	1999

Article

Year

High-mannose type oligosaccharide-dependent apoptosis in U937 cells induced by pradimicin, a mannose-binding antibiotic.

The Journal of antibiotics, 1999, Volume: 52, Issue:5

Cell surface oligosaccharides play a role in a variety of biological events such as cell adhesion and signal transduction. We have shown that BMY-28864, a semi-synthetic analog of pradimicin, induced apoptosis of U937 cells which had been incubated with 1-deoxymannojirimycin, an inhibitor of mannosidase I. BMY-28864 was not cytotoxic to the cells which had been cultivated with other glycosidase inhibitors such as castanospermine and swainsonine. We thus propose that BMY-28864 induces apoptosis by acting on a specific mannose-rich oligosaccharide, presumably (Man)9(GlcNAc)2+.

Topics: 1-Deoxynojirimycin; Anthracyclines; Antibiotics, Antineoplastic; Antifungal Agents; Apoptosis; Enzyme Inhibitors; Fluorescein-5-isothiocyanate; Glucosidases; Humans; Indolizines; Mannose; Mannosidases; Oligosaccharides; Swainsonine; U937 Cells

1999