n,n-dimethylarginine has been researched along with simvastatin in 11 studies
| Studies (n,n-dimethylarginine) | Trials (n,n-dimethylarginine) | Recent Studies (post-2010) (n,n-dimethylarginine) | Studies (simvastatin) | Trials (simvastatin) | Recent Studies (post-2010) (simvastatin) |
|---|---|---|---|---|---|
| 2,216 | 228 | 1,221 | 8,442 | 1,730 | 3,630 |
| Protein | Taxonomy | n,n-dimethylarginine (IC50) | simvastatin (IC50) |
|---|---|---|---|
| photoreceptor-specific nuclear receptor | Homo sapiens (human) | 1.164 | |
| transactivating tegument protein VP16 [Human herpesvirus 1] | Human alphaherpesvirus 1 (Herpes simplex virus type 1) | 4.426 | |
| Bile salt export pump | Homo sapiens (human) | 10 | |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) | 0.7843 | |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 9.5 | |
| Insulin receptor | Rattus norvegicus (Norway rat) | 0.0034 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 0.0034 | |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Rattus norvegicus (Norway rat) | 0.0111 | |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | 0.049 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 6.7 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abdalla, DS; Bersch, D; Bertolami, MC; Faludi, AA; Pereira, EC; Salem, M | 1 |
| Isomustajärvi, M; Laakso, J; Laaksonen, R; Lakka, TA; Lehtimäki, T; Päivä, H; Ruokonen, I; Salonen, JT; Valkonen, VP | 1 |
| Deng, HW; Jiang, DJ; Jiang, JL; Li, NS; Li, YJ; Tang, YH | 1 |
| Deng, HW; Jiang, JL; Li, NS; Li, YJ; Wang, S; Zhang, XH | 1 |
| Benndorf, RA; Bierend, A; Böger, GI; Böger, RH; Dumbadze, E; Maas, R; Rudolph, TK; Schwedhelm, E | 1 |
| Ao, Z; Bradley, BT; Ivashchenko, CY; Johns, DG; Leiper, J; Vallance, P | 1 |
| Deneva, TI; Marinov, B; Vladimirova-Kitova, LG | 1 |
| Agrawal, A; Ahmad, T; Aich, J; Ghosh, B; Mabalirajan, U; Makhija, L; Sharma, A | 1 |
| Deneva, TI; Vladimirova-Kitova, LG | 1 |
| Guo, BC; Hsu, CP; Lee, TS; Lin, SJ; Lu, TM; Shyue, SK; Zhao, JF | 1 |
| Carru, C; Ena, S; Mangoni, AA; Satta, AE; Sotgia, S; Sotgiu, E; Zinellu, A | 1 |
6 trial(s) available for n,n-dimethylarginine and simvastatin
| Article | Year |
|---|---|
Effects of simvastatin and L-arginine on vasodilation, nitric oxide metabolites and endogenous NOS inhibitors in hypercholesterolemic subjects.
Topics: Anticholesteremic Agents; Arginine; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Free Radicals; Humans; Hypercholesterolemia; Lipids; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; S-Nitrosothiols; Simvastatin; Time Factors; Vasodilation | 2003 |
Asymmetrical dimethylarginine (ADMA) and risk of acute coronary events. Does statin treatment influence plasma ADMA levels?
Topics: Acute Disease; Adult; Aged; Arginine; Atorvastatin; Biomarkers; Blood Glucose; Case-Control Studies; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Double-Blind Method; Endothelium, Vascular; Enzyme Inhibitors; Female; Finland; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Male; Middle Aged; Prospective Studies; Pyrroles; Risk Factors; Simvastatin; Statistics as Topic; Triglycerides | 2003 |
Asymmetric dimethylarginine determines the improvement of endothelium-dependent vasodilation by simvastatin: Effect of combination with oral L-arginine.
Topics: Aged; Aged, 80 and over; Arginine; C-Reactive Protein; Drug Therapy, Combination; Endothelium, Vascular; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins; Male; Middle Aged; Nitric Oxide Synthase Type III; Simvastatin; Vasodilation | 2007 |
Effect of moderate and high-dose simvastatin on asymmetric dimethylarginine-homocysteine metabolic pathways in patients with newly detected severe hypercholesterolemia.
Topics: Adult; Arginine; Biomarkers; Bulgaria; Cholesterol, LDL; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Prospective Studies; Severity of Illness Index; Simvastatin; Time Factors; Treatment Outcome | 2011 |
Simvastatin and asymmetric dimethylarginine-homocysteine metabolic pathways in patients with newly detected severe hypercholesterolemia.
Topics: Adult; Anticholesteremic Agents; Arginine; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Homocysteine; Humans; Hypercholesterolemia; Lipids; Male; Simvastatin; Treatment Outcome | 2010 |
Asymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase.
Topics: Aged; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Activation; Female; Humans; Male; Mice; Nitric Oxide; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Signal Transduction; Simvastatin | 2016 |
5 other study(ies) available for n,n-dimethylarginine and simvastatin
| Article | Year |
|---|---|
Effect of simvastatin on endothelium-dependent vaso-relaxation and endogenous nitric oxide synthase inhibitor.
Topics: Animals; Arginine; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Humans; Lipoproteins, LDL; Male; Monocytes; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Simvastatin; Tumor Necrosis Factor-alpha; Umbilical Cord; Vasodilation | 2004 |
The inhibitory effect of simvastatin on the ADMA-induced inflammatory reaction is mediated by MAPK pathways in endothelial cells.
Topics: Arginine; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intercellular Adhesion Molecule-1; MAP Kinase Signaling System; NF-kappa B; Nitric Oxide Synthase; Phosphorylation; Protein Kinase Inhibitors; Signal Transduction; Simvastatin; Tumor Necrosis Factor-alpha | 2007 |
Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2.
Topics: Amidohydrolases; Arginine; Blotting, Western; Cells, Cultured; Chromatin; Chromatography, High Pressure Liquid; DNA Primers; Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoprecipitation; Lentivirus; Nitrites; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2; Transfection | 2010 |
Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma.
Topics: Airway Remodeling; Animals; Arginine; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Chronic Disease; Disease Models, Animal; Epithelial Cells; Epithelium; Lung; Male; Mice; Mice, Inbred BALB C; Mucus; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrosation; Pneumonia; Simvastatin; Stress, Physiological | 2011 |
Effect of cholesterol lowering treatment on plasma markers of endothelial dysfunction in chronic kidney disease.
Topics: Allantoin; Anticholesteremic Agents; Arginine; Biomarkers; Cholesterol; Endothelium; Ezetimibe; Female; Humans; Inflammation; Kynurenine; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Renal Insufficiency, Chronic; Simvastatin; Uric Acid | 2016 |