Page last updated: 2024-09-03

n,n-dimethylarginine and omega-n-methylarginine

n,n-dimethylarginine has been researched along with omega-n-methylarginine in 73 studies

Compound Research Comparison

Studies (n,n-dimethylarginine)	Trials (n,n-dimethylarginine)	Recent Studies (post-2010) (n,n-dimethylarginine)	Studies (omega-n-methylarginine)	Trials (omega-n-methylarginine)	Recent Studies (post-2010) (omega-n-methylarginine)
2,216	228	1,221	4,411	344	336

Protein Interaction Comparison

Protein	Taxonomy	omega-n-methylarginine (IC50)
Neutrophil elastase	Homo sapiens (human)	0.3
Proteinase-activated receptor 1	Homo sapiens (human)	0.0018
Nitric oxide synthase, endothelial	Bos taurus (cattle)	7
Nitric oxide synthase, endothelial	Homo sapiens (human)	2.9489
Nitric oxide synthase, brain	Homo sapiens (human)	3.3983
Nitric oxide synthase, brain	Rattus norvegicus (Norway rat)	7.5
Nitric oxide synthase, inducible	Mus musculus (house mouse)	2.3
Nitric oxide synthase, inducible	Homo sapiens (human)	2.9252
Collagenase 3	Homo sapiens (human)	0.3
Nitric oxide synthase, brain	Mus musculus (house mouse)	4.3

Research

Studies (73)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	19 (26.03)	18.2507
2000's	25 (34.25)	29.6817
2010's	24 (32.88)	24.3611
2020's	5 (6.85)	2.80

Authors

Authors	Studies
Fast, W; Hong, L	1
Fast, W; Hu, S; Monzingo, AF; Robertus, JD; Schaller, TH; Wang, Y	1
Lazarides, E; Lin, JM; Wang, C	1
Calver, A; Collier, J; Leone, A; Moncada, S; Vallance, P	1
Kakimoto, Y; Kondoh, K; Kotani, K; Sano, A; Ueno, S	1
Kakimoto, Y; Kotani, K; Sano, A; Ueno, S	1
MacAllister, RJ; Vallance, P; Whitley, GS	1
Fickling, SA; MacAllister, RJ; Vallance, P; Whitley, GS	1
Bennett, T; Gardiner, SM; Kemp, PA; Moncada, S; Palmer, RM	1
Hecker, M; Meyer, J; Richter, N	1
Azuma, H; Hamasaki, H; Isotani, E; Masuda, H; Obayashi, S; Sato, J; Tamaoki, S; Udagawa, T	1
Azuma, H; Masuda, H; Niwa, K; Sato, J; Tokoro, T	1
Dillon, MJ; Frend, A; Goonasekera, CD; Rees, DD; Shah, V; Woolard, P	1
Anderstam, B; Bergström, J; Katzarski, K	1
Bremer, V; Kimoto, M; Kimura, K; Ogawa, T; Omata, M; Tojo, A; Vallance, P; Welch, WJ; Wilcox, CS	1
Barnes, PJ; Cole, PJ; Dowling, RB; Newton, R; Robichaud, A; Wilson, R	1
Azuma, H; Goto, M; Masuda, H; Tamaoki, S	1
Cartwright, JE; Holden, DP; Whitley, GS	1
Aldasoro, M; Ballester, RM; Lluch, P; Lluch, S; Medina, P; Pelligrino, DA; Segarra, G; Vila, JM	1
Azuma, H	1
Leiper, J; Vallance, P	2
Bode-Böger, SM; Böger, RH; Frölich, JC; Sandmann, J; Tsikas, D	1
Aswad, DW; Bunick, GJ; Chen, D; Hanson, BL; Harp, JM; Henschen-Edman, A; Koh, SS; Mackay, DR; Schurter, BT; Stallcup, MR	1
Aso, T; Azuma, H; Beppu, M; Goto, M; Obayashi, S	1
Azuma, H; Masuda, H	1
Azuma, H; Goto, M; Kihara, K; Masuda, H; Okuno, T; Tsujii, T	1
Cardounel, AJ; Zweier, JL	1
Azuma, H; Kihara, K; Kurosaki, E; Masuda, H; Sakai, Y; Yamauchi, Y	1
Hayashida, Y; Morishita, T; Nakashima, Y; Nakata, S; Sasaguri, Y; Suda, O; Tasaki, H; Toyohira, Y; Tsujimoto, T; Tsutsui, M; Ueno, S; Ueta, Y; Yanagihara, N	1
Augustyniak, RA; Thomas, GD; Victor, RG; Zhang, W	1
Adegoke, OA; Chevalier, S; Gougeon, R; Lamarche, M; Marliss, EB; Morais, JA; Wu, G	1
Anthony, S; Leiper, J; Vallance, P	1
Schwedhelm, E	1
Dweik, RA	1
Berka, V; Cardounel, AJ; Cui, H; Johnson, W; Kearns, P; Samouilov, A; Tsai, AL; Zweier, JL	1
Barbara, JA; Hewitson, CL; Mangoni, AA; McAteer-Carr, B; Whiting, MJ; Woodman, RJ	1
Cardounel, AJ; Chen, CA; Druhan, LJ; Forbes, SP; Pope, AJ; Zweier, JL	1
Carru, C; Deiana, L; Scanu, B; Sotgia, S; Zinellu, A	1
Azuma, H; Hirata, Y; Imamura, M; Sakurada, M; Shichiri, M	1
Bralley, JA; Chirinos, JA; Chirinos-Pacheco, J; Corrales-Medina, F; Cuba-Bustinza, C; David, R; Medina-Lezama, J; Muñoz-Atahualpa, E; Zea-Díaz, H	1
Lianos, EA; McCarthy, ET; Miura, H; Papapetropoulos, A; Savin, VJ; Sharma, M; Sharma, R; Zhou, Z	1
Blackwelder, WC; Hazen, SL; Kato, GJ; Machado, RF; Taylor, JG; Wang, Z	1
Brennan, DM; Cho, L; Hazen, SL; Tang, WH; Wang, Z	1
Al-Zobaidy, MJ; Craig, J; Martin, W	1
Jung, CS	1
Atzler, D; Bache, RJ; Böger, RH; Chen, Y; Fassett, J; Guo, H; Hu, X; Lu, Z; Schwedhelm, E; Xu, X; Zhang, P	1
Cooke, JP; Ghebremariam, YT	1
Al-Zobaidy, MJ; Brown, K; Craig, J; Martin, W; Pettifor, G	1
Barbosa, JB; Brunini, TM; Mann, GE; Matsuura, C; Mendes-Ribeiro, AC; Moraes, TL; Moss, MB; Neto, ML; Siqueira, MA	1
Caplin, B; Leiper, J	1
Linz, TH; Lunte, SM	1
Bode-Böger, SM; Bódis, J; Hantosi, E; Kovács, GL; Martens-Lobenhoffer, J; Molnár, G; Sulyok, E; Tamás, P	1
Chen, B; Chicoine, LG; Cui, H; Jin, Y; Nelin, LD; Strauch, K	1
Akiyama, K; Fujii, K; Furuchi, T; Homma, H; Katane, M; Nonaka, S; Ozeki, Y; Saitoh, Y; Sekine, M; Shimoda, K; Tsunoda, M	1
Al-Zobaidy, MJ; Martin, W	1
Appelbaum, S; Atzler, D; Bauer, C; Blankenberg, S; Böger, RH; Hoffmann, B; Lackner, KJ; Münzel, T; Ojeda, FM; Ramuschkat, M; Schnabel, RB; Schwedhelm, E; Sinning, CR; Wild, PS; Zeller, T	1
Cherkanova, MS; Gilinsky, MA; Sukhovershin, RA	1
Bazer, FW; Che, D; Hou, Y; Hu, S; Jia, S; Nawaratna, G; Wang, F; Wu, G	1
Chen, A; Chen, Y; Fassett, JT; Hou, L; Liu, X; Xu, D; Xu, Y; Yang, L; Zhuang, Y	1
Akiyama, K; Fujii, K; Homma, H; Katane, M; Miyamoto, T; Nonaka-Hashida, S; Ozeki, Y; Saitoh, Y; Sekine, M; Shimoda, K; Tsunoda, M	1
Bailey, FJ; Lundgren, BR; Moley, G; Nomura, CT	1
Arós, F; Clish, CB; Corella, D; Estruch, R; Fitó, M; Gómez-Gracia, E; Guasch-Ferré, M; Hruby, A; Hu, FB; Lapetra, J; Liang, L; Martínez-González, MA; Romaguera, D; Ros, E; Ruiz-Canela, M; Salas-Salvadó, J; Serra-Majem, L; Toledo, E; Wang, DD; Yu, E	1
Jiao, PL; Li, JK; Liu, B; Sun, JC; Tan, X; Wang, WZ; Wang, YK; Wu, ZT	1
Bode-Böger, SM; Emrich, IE; Fliser, D; Heine, GH; Martens-Lobenhoffer, J; Wagenpfeil, S; Zawada, AM	1
Chen, Y; Liu, X; Shang, R; Xu, X	1
Arós, F; Bullo, M; Clish, C; Cofán, M; Corella, D; Dennis, C; Estruch, R; Fitó, M; Guasch-Ferré, M; Gutiérrez-Bedmar, M; Hu, FB; Lapetra, J; Liang, L; Martínez-González, MA; Papandreou, C; Razquin, C; Romaguera, D; Ros, E; Ruiz-Canela, M; Salas-Salvadó, J; Serra-Majem, L; Sorlí, JV; Toledo, E; Wang, DD; Yu, E	1
Abusoglu, G; Abusoglu, S; Avci, A; Demir, K; Eryavuz, D; Hosaf, M; Unlu, A	1
Driver, T; Edelson-Averbukh, M; Katsanovskaja, K; Pipkorn, R	1
Gao, Y; Huang, H; Huang, M; Lv, W; Tang, H; Xiao, H	1
Berent, TE; Dorschner, JM; Jatoi, A; Kumar, R; Kunz, HE; Lanza, IR; Meyer, T; Wang, X	1
Alptekin, H; Karaman, S; Onmaz, DE; Sivrikaya, A	1
Doğan, Ö; Haşimi, A; Serdar, CC; Serdar, MA	1

Reviews

10 review(s) available for n,n-dimethylarginine and omega-n-methylarginine

Article	Year
Biological significance of endogenous methylarginines that inhibit nitric oxide synthases. Cardiovascular research, 1999, Aug-15, Volume: 43, Issue:3 Topics: Amidohydrolases; Animals; Arginine; Cytosol; Enzyme Inhibitors; Humans; Hydrolases; Isoenzymes; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Protein-Arginine N-Methyltransferases	1999
[Biological and pathophysiological roles of endogenous methylarginines as inhibitors of nitric oxide synthase]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2002, Volume: 119, Issue:1 Topics: Animals; Arginine; Nitric Oxide Synthase; omega-N-Methylarginine	2002
Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway. Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:6 Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Cardiovascular Physiological Phenomena; Diabetes Mellitus; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Mice; Models, Biological; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Pre-Eclampsia; Pregnancy; Protein-Arginine N-Methyltransferases; Renal Insufficiency	2004
Nitric oxide pathway as new drug targets for refractory hypertension. Current pharmaceutical design, 2005, Volume: 11, Issue:25 Topics: Animals; Antihypertensive Agents; Arginine; Blood Pressure; Endothelium, Vascular; Humans; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Signal Transduction; Superoxides	2005
Endogenous production of nitric oxide synthase inhibitors. Vascular medicine (London, England), 2005, Volume: 10 Suppl 1 Topics: Arginine; Enzyme Inhibitors; Humans; Isoenzymes; Nitric Oxide Synthase; omega-N-Methylarginine; Protein-Arginine N-Methyltransferases; Renal Insufficiency	2005
Quantification of ADMA: analytical approaches. Vascular medicine (London, England), 2005, Volume: 10 Suppl 1 Topics: Arginine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Enzyme-Linked Immunosorbent Assay; Gas Chromatography-Mass Spectrometry; Humans; omega-N-Methylarginine; Reproducibility of Results	2005
The lung in the balance: arginine, methylated arginines, and nitric oxide. American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 292, Issue:1 Topics: Animals; Arginine; Humans; Lung; Methylation; Models, Biological; Nitric Oxide; omega-N-Methylarginine; Protein-Arginine N-Methyltransferases	2007
Endogenous nitric oxide synthase inhibitors in the biology of disease: markers, mediators, and regulators? Arteriosclerosis, thrombosis, and vascular biology, 2012, Volume: 32, Issue:6 Topics: Amidohydrolases; Animals; Arginine; Binding Sites; Binding, Competitive; Biomarkers; Cardiovascular Agents; Cardiovascular Diseases; Catalytic Domain; Enzyme Inhibitors; Humans; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine	2012
Effect of asymmetric dimethylarginine (ADMA) on heart failure development. Nitric oxide : biology and chemistry, 2016, Apr-01, Volume: 54 Topics: Amidohydrolases; Animals; Arginine; Heart Failure; Humans; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Peroxynitrous Acid; Signal Transduction; Superoxides	2016
Asymmetric dimethylarginine (ADMA) as an important risk factor for the increased cardiovascular diseases and heart failure in chronic kidney disease. Nitric oxide : biology and chemistry, 2018, 08-01, Volume: 78 Topics: Amidohydrolases; Animals; Arginine; Endothelium, Vascular; Heart Failure; Humans; Nitric Oxide Synthase; omega-N-Methylarginine; Renal Insufficiency, Chronic; Risk Factors; Signal Transduction	2018

Trials

1 trial(s) available for n,n-dimethylarginine and omega-n-methylarginine

Article	Year
Effects of some guanidino compounds on human cerebral arteries. Stroke, 1999, Volume: 30, Issue:10 Topics: Adult; Aged; Arginine; Enzyme Inhibitors; Female; Guanidines; Humans; Male; Methylguanidine; Middle Aged; Middle Cerebral Artery; Nitric Oxide Synthase; omega-N-Methylarginine; Vasoconstrictor Agents; Vasodilator Agents	1999

Other Studies

62 other study(ies) available for n,n-dimethylarginine and omega-n-methylarginine

Article	Year
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia. The Journal of biological chemistry, 2007, Nov-30, Volume: 282, Issue:48 Topics: Amidohydrolases; Amino Acid Sequence; Animals; Binding Sites; Cloning, Molecular; Cysteine; Dose-Response Relationship, Drug; Drug Design; Homocysteine; Humans; Hydrogen Peroxide; Hyperhomocysteinemia; Kinetics; Molecular Sequence Data; Oxidation-Reduction; Sequence Homology, Amino Acid; Substrate Specificity	2007
Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide. Biochemistry, 2009, Sep-15, Volume: 48, Issue:36 Topics: Amidines; Amidohydrolases; Crystallography, X-Ray; Drug Delivery Systems; Enzyme Inhibitors; Humans; Nitric Oxide; Nitric Oxide Synthase Type I; Ornithine; Recombinant Proteins; Substrate Specificity; Thiourea	2009
Methylations of 70,000-Da heat shock proteins in 3T3 cells: alterations by arsenite treatment, by different stages of growth and by virus transformation. Archives of biochemistry and biophysics, 1992, Aug-15, Volume: 297, Issue:1 Topics: 3T3 Cells; Animals; Arginine; Arsenic; Arsenites; Avian Sarcoma Viruses; Cell Division; Cell Transformation, Viral; Chromatography, Ion Exchange; Electrophoresis, Gel, Two-Dimensional; Heat-Shock Proteins; Lysine; Methionine; Methylation; Mice; Molecular Weight; omega-N-Methylarginine	1992
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet (London, England), 1992, Mar-07, Volume: 339, Issue:8793 Topics: Adult; Animals; Aorta; Arginine; Blood Pressure; Cells, Cultured; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Forearm; Guinea Pigs; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; omega-N-Methylarginine; Rats; Reference Values; Regional Blood Flow	1992
Distribution of free methylarginines in rat tissues and in the bovine brain. Journal of neurochemistry, 1992, Volume: 59, Issue:6 Topics: Animals; Arginine; Brain Chemistry; Cattle; Intestines; Male; Myocardium; omega-N-Methylarginine; Rats; Rats, Wistar; Spleen; Testis; Tissue Distribution	1992
Isolation and identification of methylarginines from bovine brain. Journal of neurochemistry, 1992, Volume: 58, Issue:3 Topics: Animals; Arginine; Brain; Cattle; Chromatography, High Pressure Liquid; Electrophoresis, Paper; omega-N-Methylarginine	1992
Effects of guanidino and uremic compounds on nitric oxide pathways. Kidney international, 1994, Volume: 45, Issue:3 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Guanidines; Humans; Macrophages; Mice; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Saphenous Vein	1994
Metabolism of methylarginines by human vasculature; implications for the regulation of nitric oxide synthesis. British journal of pharmacology, 1994, Volume: 112, Issue:1 Topics: Amino Acid Oxidoreductases; Arginase; Arginine; Cells, Cultured; Chromatography, High Pressure Liquid; Citrulline; Cytosol; Endothelium, Vascular; Humans; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Saphenous Vein; Umbilical Veins	1994
Regional and cardiac haemodynamic effects of NG, NG,dimethyl-L-arginine and their reversibility by vasodilators in conscious rats. British journal of pharmacology, 1993, Volume: 110, Issue:4 Topics: Animals; Arginine; Glutathione; Hemodynamics; Hydralazine; Male; Nitroprusside; Nitroso Compounds; omega-N-Methylarginine; Penicillamine; Rats; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Vasodilator Agents	1993
High-performance liquid chromatographic determination of nitric oxide synthase-related arginine derivatives in vitro and in vivo. Analytical biochemistry, 1997, Apr-05, Volume: 247, Issue:1 Topics: Animals; Arginine; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Female; Humans; In Vitro Techniques; Macrophages, Alveolar; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Reference Values; Reproducibility of Results; Sensitivity and Specificity	1997
Effect of nicotine on the intimal hyperplasia after endothelial removal of the rabbit carotid artery. General pharmacology, 1997, Volume: 28, Issue:5 Topics: Animals; Arginine; Body Weight; Carotid Arteries; Endothelin-1; Endothelium, Vascular; Hyperplasia; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nicotine; Nitric Oxide Synthase; omega-N-Methylarginine; Rabbits; Tunica Intima	1997
A possible role of endogenous inhibitor for nitric oxide synthesis in the bovine ciliary muscle. Experimental eye research, 1997, Volume: 64, Issue:5 Topics: Animals; Arginine; Calcimycin; Cattle; Ciliary Body; Ionophores; Muscle Relaxation; Nitric Oxide; Nitroprusside; omega-N-Methylarginine	1997
Nitric oxide synthase inhibitors and hypertension in children and adolescents. Journal of hypertension, 1997, Volume: 15, Issue:8 Topics: Adolescent; Animals; Arginine; Child; Endothelium, Vascular; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Humans; Hypertension; Hypertension, Renal; Hypertension, Renovascular; In Vitro Techniques; Male; Mice; Muscle Contraction; Nitric Oxide Synthase; omega-N-Methylarginine; Phenylephrine; Renin; Vasoconstrictor Agents	1997
Serum levels of NG, NG-dimethyl-L-arginine, a potential endogenous nitric oxide inhibitor in dialysis patients. Journal of the American Society of Nephrology : JASN, 1997, Volume: 8, Issue:9 Topics: Arginine; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Humans; Nitric Oxide; omega-N-Methylarginine; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis	1997
Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney. Kidney international, 1997, Volume: 52, Issue:6 Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Enzyme Inhibitors; Hydrolases; Kidney Glomerulus; Loop of Henle; Male; Methylation; Microscopy, Immunoelectron; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Tritium	1997
Effect of inhibition of nitric oxide synthase on Pseudomonas aeruginosa infection of respiratory mucosa in vitro. American journal of respiratory cell and molecular biology, 1998, Volume: 19, Issue:6 Topics: Arginine; Bacterial Adhesion; Enzyme Inhibitors; Gene Expression; Humans; Microscopy, Electron, Scanning; Mucous Membrane; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; omega-N-Methylarginine; Organ Culture Techniques; Pseudomonas aeruginosa; Respiratory System; RNA, Messenger	1998
Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia. British journal of pharmacology, 1999, Volume: 126, Issue:1 Topics: Alloxan; Animals; Arginine; Blood Glucose; Body Weight; Carotid Arteries; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Hyperglycemia; Hyperplasia; In Vitro Techniques; Male; Nitric Oxide; omega-N-Methylarginine; Rabbits; Tunica Intima; Tunica Media; Weight Gain	1999
Hepatocyte growth factor regulates human trophoblast motility and invasion: a role for nitric oxide. British journal of pharmacology, 1999, Volume: 128, Issue:1 Topics: Arginine; Cell Division; Cell Line; Cell Movement; Cell Size; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Induction; Female; Fibrin; Hepatocyte Growth Factor; Humans; Integrins; Interleukin-1; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; RNA, Messenger; Transfection; Trophoblasts; Tumor Necrosis Factor-alpha	1999
[Role of L-arginine--endogenous NOS inhibitors--endothelin-1 pathway for the vascular remodelling]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1999, Volume: 114 Suppl 1 Topics: Animals; Arginine; Carotid Arteries; Cell Division; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Male; Muscle, Smooth, Vascular; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rabbits; Regeneration	1999
Endogenous nitric oxide synthase inhibitors are responsible for the L-arginine paradox. FEBS letters, 2000, Jul-28, Volume: 478, Issue:1-2 Topics: Animals; Arginine; Binding, Competitive; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Meta-Analysis as Topic; Models, Biological; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Thermodynamics	2000
Methylation of histone H3 by coactivator-associated arginine methyltransferase 1. Biochemistry, 2001, May-15, Volume: 40, Issue:19 Topics: Amino Acid Sequence; Amino Acids; Animals; Arginine; Catalysis; Cattle; Chickens; Chromatography, High Pressure Liquid; Enzyme Activation; Histones; Kinetics; Methylation; Molecular Sequence Data; Oligopeptides; omega-N-Methylarginine; Protein-Arginine N-Methyltransferases; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity	2001
Endogenous nitric oxide synthase inhibitors in endothelial cells, endothelin-1 within the vessel wall, and intimal hyperplasia in perimenopausal human uterine arteries. Journal of cardiovascular pharmacology, 2002, Volume: 39, Issue:2 Topics: Adult; Arginine; Arteries; Chromatography, High Pressure Liquid; Climacteric; Cyclic GMP; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hyperplasia; In Vitro Techniques; Middle Aged; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Tunica Intima; Tunica Media; Uterus	2002
Accumulated endogenous NOS inhibitors, decreased NOS activity, and impaired cavernosal relaxation with ischemia. American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:6 Topics: Animals; Arginine; Calcium; Carbachol; Cholinergic Agonists; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Endothelium, Vascular; Enzyme Inhibitors; Iliac Artery; Impotence, Vasculogenic; In Vitro Techniques; Ischemia; Male; Nitric Oxide Synthase; omega-N-Methylarginine; Penis; Rabbits; Vasoconstrictor Agents; Vasodilator Agents	2002
Endogenous methylarginines regulate neuronal nitric-oxide synthase and prevent excitotoxic injury. The Journal of biological chemistry, 2002, Sep-13, Volume: 277, Issue:37 Topics: Animals; Arginine; Cell Survival; Cells, Cultured; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; omega-N-Methylarginine; Rats	2002
Involvement of increased arginase activity in impaired cavernous relaxation with aging in the rabbit. The Journal of urology, 2004, Volume: 172, Issue:1 Topics: Aging; Animals; Arginase; Arginine; Carbachol; Cholinergic Agonists; Endothelium, Vascular; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; omega-N-Methylarginine; Penis; Rabbits	2004
Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice: involvement of renin-angiotensin system and oxidative stress. Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:9 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Coronary Disease; Enzyme Induction; Homocysteine; Imidazoles; Infusion Pumps, Implantable; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcirculation; Myocardium; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Olmesartan Medoxomil; omega-N-Methylarginine; Oxidative Stress; Peptidyl-Dipeptidase A; Renin-Angiotensin System; Superoxides; Tetrazoles; Thiazepines	2004
Elevations of plasma methylarginines in obesity and ageing are related to insulin sensitivity and rates of protein turnover. Diabetologia, 2006, Volume: 49, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aging; Arginine; Blood Glucose; Body Composition; Female; Glucose; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Lipids; Male; Metabolic Syndrome; Middle Aged; Obesity; omega-N-Methylarginine; Proteins; Regression Analysis; Sex Characteristics	2006
Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function. The Journal of biological chemistry, 2007, Jan-12, Volume: 282, Issue:2 Topics: Animals; Aorta; Arginine; Carotid Artery Injuries; Catheterization; Cattle; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Kinetics; Male; Methylation; Nitric Oxide; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Rats; Rats, Wistar; Vasodilation	2007
Symmetric dimethylarginine is an independent predictor of intradialytic hypotension. American journal of hypertension, 2008, Volume: 21, Issue:8 Topics: Aged; Arginine; Biomarkers; Blood Pressure; Female; Humans; Hypotension; Kidney Failure, Chronic; Male; Middle Aged; omega-N-Methylarginine; Predictive Value of Tests; Renal Dialysis	2008
Regulation of eNOS-derived superoxide by endogenous methylarginines. Biochemistry, 2008, Jul-08, Volume: 47, Issue:27 Topics: Arginine; Biopterins; Electron Spin Resonance Spectroscopy; Heme; Humans; NADP; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Superoxides	2008
Determination of protein-incorporated methylated arginine reference values in healthy subjects whole blood and evaluation of factors affecting protein methylation. Clinical biochemistry, 2008, Volume: 41, Issue:14-15 Topics: Adult; Aged; Aged, 80 and over; Arginine; Female; Health; Humans; Male; Methylation; Middle Aged; omega-N-Methylarginine; Proteins; Reference Values; Regression Analysis	2008
Nitric oxide upregulates dimethylarginine dimethylaminohydrolase-2 via cyclic GMP induction in endothelial cells. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 52, Issue:5 Topics: Amidohydrolases; Animals; Arginine; Carbazoles; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Male; Natriuretic Peptide, C-Type; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitro Compounds; omega-N-Methylarginine; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Up-Regulation	2008
Endogenous nitric oxide synthase inhibitors, arterial hemodynamics, and subclinical vascular disease: the PREVENCION Study. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 52, Issue:6 Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Blood Flow Velocity; Blood Pressure; Carotid Artery Diseases; Female; Humans; Hypertension; Male; Middle Aged; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Predictive Value of Tests; Prognosis; Pulsatile Flow; Regression Analysis; Risk Factors	2008
ADMA injures the glomerular filtration barrier: role of nitric oxide and superoxide. American journal of physiology. Renal physiology, 2009, Volume: 296, Issue:6 Topics: Albumins; Animals; Anthracenes; Arginine; Free Radical Scavengers; Glomerular Basement Membrane; Guanylate Cyclase; Male; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidation-Reduction; Permeability; Propane; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Superoxides	2009
Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death. British journal of haematology, 2009, Volume: 145, Issue:4 Topics: Anemia, Sickle Cell; Arginine; Case-Control Studies; Citrulline; Follow-Up Studies; Hemolysis; Humans; Hypertension, Pulmonary; Kidney Diseases; Linear Models; Nitric Oxide Synthase; omega-N-Methylarginine; Oxygen; Proportional Hazards Models; Risk; Survival Rate	2009
Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: potential mechanisms beyond nitric oxide synthase inhibition. Arteriosclerosis, thrombosis, and vascular biology, 2009, Volume: 29, Issue:9 Topics: Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Citrulline; Coronary Artery Disease; Creatinine; Female; Humans; Lysine; Male; Metabolomics; Methylation; Middle Aged; Nitric Oxide Synthase; Odds Ratio; omega-N-Methylarginine; Ornithine; Prognosis; Prospective Studies; Protein Processing, Post-Translational; Risk Assessment; Risk Factors; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Time Factors	2009
Differential sensitivity of basal and acetylcholine-induced activity of nitric oxide to blockade by asymmetric dimethylarginine in the rat aorta. British journal of pharmacology, 2010, Volume: 160, Issue:6 Topics: Acetylcholine; Animals; Aorta; Arginine; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Nitric Oxide; omega-N-Methylarginine; Phenylephrine; Rats; Rats, Wistar	2010
Nitric oxide synthase inhibitors and cerebral vasospasm. Acta neurochirurgica. Supplement, 2011, Volume: 110, Issue:Pt 1 Topics: Animals; Arginine; Citrulline; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; S-Adenosylmethionine; Vasospasm, Intracranial	2011
Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:7 Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Cardiovascular Diseases; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Female; Genotype; Hypertension; Infusion Pumps, Implantable; Male; Mice; Mice, 129 Strain; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phenotype; Risk Factors; RNA Interference; Substrate Specificity; Time Factors; Transfection	2011
DDAH says NO to ADMA. Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:7 Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Endothelial Cells; Humans; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Risk Factors; Substrate Specificity	2011
Stimulus-specific blockade of nitric oxide-mediated dilatation by asymmetric dimethylarginine (ADMA) and monomethylarginine (L-NMMA) in rat aorta and carotid artery. European journal of pharmacology, 2011, Dec-30, Volume: 673, Issue:1-3 Topics: Animals; Aorta; Arginine; Carotid Arteries; Female; Male; Naphthyridines; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Phenylephrine; Pyrimidines; Rats; Rats, Wistar; Superoxide Dismutase; Vasodilation	2011
Nitric oxide activity in platelets of dengue haemorrhagic fever patients: the apparent paradoxical role of ADMA and l-NMMA. Transactions of the Royal Society of Tropical Medicine and Hygiene, 2012, Volume: 106, Issue:3 Topics: Adult; Arginine; Blood Platelets; Brazil; Enzyme Inhibitors; Female; Humans; Male; Nitric Oxide Synthase; omega-N-Methylarginine; Platelet Aggregation; Severe Dengue; Thrombocytopenia	2012
Heat-assisted extraction for the determination of methylarginines in serum by CE. Electrophoresis, 2013, Volume: 34, Issue:11 Topics: Arginine; Cardiovascular Diseases; Electrophoresis, Capillary; Hot Temperature; Humans; omega-N-Methylarginine; Solid Phase Extraction	2013
L-arginine metabolism in early-onset and late-onset pre-eclamptic pregnancies. Scandinavian journal of clinical and laboratory investigation, 2013, Volume: 73, Issue:5 Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Female; Fetal Blood; Humans; omega-N-Methylarginine; Ornithine; Pre-Eclampsia; Pregnancy; Young Adult	2013
Asymmetric dimethylarginine does not inhibit arginase activity and is pro-proliferative in pulmonary endothelial cells. Clinical and experimental pharmacology & physiology, 2014, Volume: 41, Issue:7 Topics: Animals; Arginase; Arginine; Cattle; Cell Proliferation; Endothelial Cells; Lung; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Substrate Specificity; Urea	2014
Simultaneous determination of N(G)-monomethyl-L-arginine, N(G),N(G)-dimethyl-L-arginine, N(G),N(G')-dimethyl-L-arginine, and L-arginine using monolithic silica disk-packed spin columns and a monolithic silica column. Journal of separation science, 2014, Volume: 37, Issue:16 Topics: Arginine; Calibration; Chromatography, High Pressure Liquid; Fluorescent Dyes; Healthy Volunteers; Humans; Linear Models; omega-N-Methylarginine; Reproducibility of Results; Silicon Dioxide; Solid Phase Extraction	2014
The ability of asymmetric dimethylarginine (ADMA) or monomethylarginine (L-NMMA) to block endothelium-dependent, nitric oxide-mediated relaxation in rat aorta is inversely related to the efficacy of the relaxant stimulus. European journal of pharmacology, 2014, Oct-15, Volume: 741 Topics: Animals; Aorta; Arginine; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Wistar; Vasodilation	2014
ADMA, subclinical changes and atrial fibrillation in the general population. International journal of cardiology, 2016, Jan-15, Volume: 203 Topics: Adult; Aged; Arginine; Atrial Fibrillation; Biomarkers; Chromatography, Liquid; Echocardiography; Electrocardiography; Female; Germany; Humans; Male; Middle Aged; Morbidity; omega-N-Methylarginine; Oxidative Stress; Population Surveillance; Tandem Mass Spectrometry	2016
Methylarginines in Mice with Experimental Atherosclerosis. Bulletin of experimental biology and medicine, 2015, Volume: 160, Issue:1 Topics: Animals; Arginine; Atherosclerosis; Cholesterol; Endothelium, Vascular; Male; Mice; Mice, Inbred CBA; Nitric Oxide Synthase; omega-N-Methylarginine; Poloxamer; Triglycerides	2015
Whole-body synthesis of L-homoarginine in pigs and rats supplemented with L-arginine. Amino acids, 2016, Volume: 48, Issue:4 Topics: Animal Feed; Animals; Arginine; Body Weight; Creatinine; Dietary Supplements; Female; Glycine max; Homoarginine; Male; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Swine; Zea mays	2016
Plasma concentrations of three methylated arginines, endogenous nitric oxide synthase inhibitors, in schizophrenic patients undergoing antipsychotic drug treatment. Psychiatry research, 2016, Apr-30, Volume: 238 Topics: Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Arginine; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; omega-N-Methylarginine; Schizophrenia; Treatment Outcome; Young Adult	2016
DdaR (PA1196) Regulates Expression of Dimethylarginine Dimethylaminohydrolase for the Metabolism of Methylarginines in Pseudomonas aeruginosa PAO1. Journal of bacteriology, 2017, 04-15, Volume: 199, Issue:8 Topics: Amidohydrolases; Arginine; Bacterial Proteins; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; omega-N-Methylarginine; Pseudomonas aeruginosa; RNA Polymerase Sigma 54	2017
Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study. The Journal of clinical endocrinology and metabolism, 2017, 06-01, Volume: 102, Issue:6 Topics: Aged; Arginine; Cardiovascular Diseases; Case-Control Studies; Chromatography, Liquid; Citrulline; Cohort Studies; Female; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; omega-N-Methylarginine; Ornithine; Proportional Hazards Models; Prospective Studies; Risk Factors; Stroke; Tandem Mass Spectrometry	2017
The asymmetric dimethylarginine-mediated inhibition of nitric oxide in the rostral ventrolateral medulla contributes to regulation of blood pressure in hypertensive rats. Nitric oxide : biology and chemistry, 2017, Jul-01, Volume: 67 Topics: Amidohydrolases; Angiotensin II; Animals; Arginine; Blood Pressure; Heart Rate; Kidney; Losartan; Male; Medulla Oblongata; Nitric Oxide; omega-N-Methylarginine; Protein-Arginine N-Methyltransferases; Rats, Inbred WKY; Rats, Sprague-Dawley; Sympathetic Nervous System	2017
Symmetric dimethylarginine (SDMA) outperforms asymmetric dimethylarginine (ADMA) and other methylarginines as predictor of renal and cardiovascular outcome in non-dialysis chronic kidney disease. Clinical research in cardiology : official journal of the German Cardiac Society, 2018, Volume: 107, Issue:3 Topics: Aged; Arginine; Biomarkers; Cardiovascular Diseases; Chromatography, Liquid; Disease Progression; Female; Germany; Humans; Incidence; Male; Middle Aged; omega-N-Methylarginine; Prognosis; Renal Dialysis; Renal Insufficiency, Chronic; Risk Assessment; Risk Factors	2018
Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial. Diabetes, obesity & metabolism, 2019, Volume: 21, Issue:2 Topics: Aged; Aged, 80 and over; Arginine; Case-Control Studies; Citrulline; Cohort Studies; Diabetes Mellitus, Type 2; Diet, Fat-Restricted; Diet, Mediterranean; Female; Humans; Incidence; Insulin Resistance; Male; Middle Aged; omega-N-Methylarginine; Ornithine; Risk Factors	2019
Total methylated arginine load as a risk parameter in subjects with masked hypertension. Clinical and experimental hypertension (New York, N.Y. : 1993), 2020, Volume: 42, Issue:2 Topics: Arginine; Biomarkers; Blood Pressure Determination; Female; Humans; Hypertension; Male; Masked Hypertension; Middle Aged; Nitric Oxide; omega-N-Methylarginine; Risk Factors	2020
Negative Ion Mode Collision-Induced Dissociation for Analysis of Protein Arginine Methylation. Journal of the American Society for Mass Spectrometry, 2019, Volume: 30, Issue:7 Topics: Amino Acid Sequence; Arginine; omega-N-Methylarginine; Peptides; Protein Processing, Post-Translational; Proteins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2019
The Role of Reactive Oxygen Species and Nitric Oxide in the Inhibition of Oxidative medicine and cellular longevity, 2020, Volume: 2020 Topics: Arginine; Catecholamines; Cell Line; Enzyme Inhibitors; Humans; Imidazolines; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Peptide Hydrolases; Reactive Oxygen Species; Trichophyton	2020
Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting. The Journal of biological chemistry, 2020, 12-18, Volume: 295, Issue:51 Topics: Animals; Arginine; Cachexia; Female; Heterografts; Humans; Male; Mice; Mice, Inbred C57BL; Mitochondria, Muscle; Muscle Proteins; Neoplasms; omega-N-Methylarginine	2020
Altered methylarginine levels after surgery in subjects with multinodular goiter. Hormone molecular biology and clinical investigation, 2021, Feb-22, Volume: 42, Issue:3 Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Goiter, Nodular; Humans; Male; Middle Aged; omega-N-Methylarginine; Postoperative Period; Sensitivity and Specificity	2021
Association of serum ADMA, SDMA and L-NMMA concentrations with disease progression in COVID-19 patients. Biochemia medica, 2023, Feb-15, Volume: 33, Issue:1 Topics: Arginine; COVID-19; Disease Progression; Humans; omega-N-Methylarginine	2023