Compounds > n,n-dimethylarginine
Page last updated: 2024-09-03

n,n-dimethylarginine and ng-nitroarginine methyl ester

n,n-dimethylarginine has been researched along with ng-nitroarginine methyl ester in 39 studies

Compound Research Comparison

Studies
(n,n-dimethylarginine)		Trials
(n,n-dimethylarginine)		Recent Studies (post-2010)
(n,n-dimethylarginine)		Studies
(ng-nitroarginine methyl ester)		Trials
(ng-nitroarginine methyl ester)		Recent Studies (post-2010) (ng-nitroarginine methyl ester)
2,2162281,22112,6401172,342

Protein Interaction Comparison

ProteinTaxonomyn,n-dimethylarginine (IC50)ng-nitroarginine methyl ester (IC50)
Neutrophil elastaseHomo sapiens (human)2.7
Nitric oxide synthase, endothelialHomo sapiens (human)2.1
Nitric oxide synthase, brainHomo sapiens (human)1.1167
Nitric oxide synthase, inducibleMus musculus (house mouse)2.6
Nitric oxide synthase, inducibleHomo sapiens (human)8
Collagenase 3Homo sapiens (human)2.7

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (7.69)18.2507
2000's20 (51.28)29.6817
2010's14 (35.90)24.3611
2020's2 (5.13)2.80

Authors

AuthorsStudies
Fickling, SA; MacAllister, RJ; Vallance, P; Whitley, GS1
Granger, DN; Grisham, MB; Kurose, I; Wolf, R1
Barefield, D; Ram, S; White, R; Work, J1
Kimura, K; Masuyama, Y; Nishio, I; Tsuda, K1
Kimura, K; Masuyama, Y; Nishio, I; Shimamoto, Y; Tsuda, K1
Kimura, K; Kinoshita, Y; Masuyama, Y; Nishio, I; Tsuda, K1
Azuma, H; Goto, M; Kihara, K; Masuda, H; Okuno, T; Tsujii, T1
Cooke, JP; Losordo, DW1
Bode-Böger, SM; Fliser, D; Frölich, JC; Haller, H; Hoeper, MM; Impraim, B; Kielstein, JT; Simmel, S; Tsikas, D1
Goligorsky, MS; Kajstura, M; Sawamura, T; Smirnova, IV1
Dietz, S; Faurie, F; Gross, R; Lajoix, AD; Linck, N; Mani, JC; Petit, P; Pugnière, M; Ribes, G; Roquet, F1
Boucher, JL; Brunet, A; David-Dufilho, M; Devynck, MA; Millanvoye, E; Rendu, F; Topal, G1
Hayashida, Y; Morishita, T; Nakashima, Y; Nakata, S; Sasaguri, Y; Suda, O; Tasaki, H; Toyohira, Y; Tsujimoto, T; Tsutsui, M; Ueno, S; Ueta, Y; Yanagihara, N1
Nishio, I; Tsuda, K1
Blau, HM; Cooke, JP; Dayoub, H; Jacobi, J; Kimoto, M; Patterson, AJ; Sydow, K; von Degenfeld, G; Wang, B; Zhang, Y1
Augustyniak, RA; Morgan, DA; Victor, RG; Zhang, W1
Buerk, DG; Carlsson, PO; Hansell, P; Liss, P; Palm, F1
Augustyniak, RA; Thomas, GD; Victor, RG; Zhang, W1
Fevery, J; Laleman, W; Nevens, F; Omasta, A; Roskams, T; Severi, T; Van de Casteele, M; Van Landeghem, L; van Pelt, J; Vander Elst, I; Zeegers, M1
Bode-Böger, SM; Bukowska, A; Lendeckel, U; Martens-Lobenhoffer, J; Scalera, F; Täger, M1
Ayajiki, K; Gemba, M; Okamura, T; Shinozaki, K; Yamamizu, K1
Brown, RD; Carlström, M; Edlund, J; Larsson, E; Palm, F; Persson, AE; Sällström, J; Teerlink, T; Wåhlin, N1
Chen, JS; Chen, JW; Chen, YH; Huang, PH; Lin, FY; Lin, SJ; Sata, M; Tsai, HY; Wu, TC1
Meng, X; Shan, HY; Yi, TN; Zhang, J; Zhang, JS; Zhao, HY1
Bigé, N; Boffa, JJ; Chatziantoniou, C; Dussaule, JC; Jouanneau, C; Mihout, F; Ronco, P; Shweke, N1
Atzler, D; Bache, RJ; Böger, RH; Chen, Y; Fassett, J; Guo, H; Hu, X; Lu, Z; Schwedhelm, E; Xu, X; Zhang, P1
Al-Zobaidy, MJ; Brown, K; Craig, J; Martin, W; Pettifor, G1
Billecke, S; Chen, AF; Craig, T; D'Alecy, LG; Haywood, JR; Hinojosa-Laborde, C; Northcott, CA; Patel, KP1
Hu, CP; Jiang, JL; Li, YJ; Nie, SD; Wang, S; Yuan, Q; Zhang, WF; Zhou, Z1
Closs, EI; Daiber, A; Förstermann, U; Habermeier, A; Jabs, A; Münzel, T; Ostad, MA; Simon, A; Warnholtz, A1
Fung, HL; Mohan, S1
Helle, F; Hultström, M; Iversen, BM; Palm, F; Schwartz, D; Schwartz, IF; Skogstrand, T1
Cheng, MC; Huang, LT; Tain, YL; Wu, TH1
Chen, B; Chicoine, LG; Cui, H; Jin, Y; Nelin, LD; Strauch, K1
Chakraborti, A; Gulati, K; Ray, A1
Barančík, M; Berenyiová, A; Dovinová, I; Hrabárová, E; Jansen, E; Kvandová, M; Majzúnová, M1
Cai, GW; Cheng, P; Ding, L; Gao, S; Hu, J; Huang, GY; Wang, L; Zhang, YX1
Gulhan, MF; Ozdemir, B; Sahna, E; Selamoglu, Z1
Kellum, JA; Lee, Y; Singh, J1

Reviews

2 review(s) available for n,n-dimethylarginine and ng-nitroarginine methyl ester

ArticleYear
Nitric oxide pathway as new drug targets for refractory hypertension.
    Current pharmaceutical design, 2005, Volume: 11, Issue:25

    Topics: Animals; Antihypertensive Agents; Arginine; Blood Pressure; Endothelium, Vascular; Humans; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Signal Transduction; Superoxides

2005
A new perspective on NO pathway in sepsis and ADMA lowering as a potential therapeutic approach.
    Critical care (London, England), 2022, 08-12, Volume: 26, Issue:1

    Topics: Animals; Arginine; Humans; Ischemia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Sepsis

2022

Trials

2 trial(s) available for n,n-dimethylarginine and ng-nitroarginine methyl ester

ArticleYear
Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans.
    Circulation, 2004, Jan-20, Volume: 109, Issue:2

    Topics: Arginine; Cardiac Output; Cross-Over Studies; Cyclic GMP; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Hemodynamics; Humans; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Vascular Resistance

2004
Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailability.
    Arteriosclerosis, thrombosis, and vascular biology, 2010, Volume: 30, Issue:4

    Topics: AC133 Antigen; Adult; Alcoholic Beverages; Antigens, CD; Antigens, CD34; Arginine; Beer; Biological Availability; Biomarkers; Cell Adhesion; Cell Movement; Cell Proliferation; Cells, Cultured; Cellular Senescence; Endothelial Cells; Enzyme Inhibitors; Ethanol; Female; Flow Cytometry; Glycoproteins; Humans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Peptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Prospective Studies; Proto-Oncogene Proteins c-akt; Resveratrol; Stem Cells; Stilbenes; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor Receptor-2; Vasodilation; Wine

2010

Other Studies

35 other study(ies) available for n,n-dimethylarginine and ng-nitroarginine methyl ester

ArticleYear
Metabolism of methylarginines by human vasculature; implications for the regulation of nitric oxide synthesis.
    British journal of pharmacology, 1994, Volume: 112, Issue:1

    Topics: Amino Acid Oxidoreductases; Arginase; Arginine; Cells, Cultured; Chromatography, High Pressure Liquid; Citrulline; Cytosol; Endothelium, Vascular; Humans; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Saphenous Vein; Umbilical Veins

1994
Effects of an endogenous inhibitor of nitric oxide synthesis on postcapillary venules.
    The American journal of physiology, 1995, Volume: 268, Issue:6 Pt 2

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Flow Velocity; Blood Platelets; Cell Adhesion; Cell Aggregation; Endothelium, Vascular; Kinetics; Leukocytes; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Splanchnic Circulation; Stereoisomerism; Venules

1995
Peritoneal dialysis solutions reverse the hemodynamic effects of nitric oxide synthesis inhibitors.
    Kidney international, 1995, Volume: 48, Issue:6

    Topics: Animals; Arginine; Dialysis Solutions; Enzyme Inhibitors; Hemodynamics; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peritoneal Dialysis; Rats; Rats, Sprague-Dawley; Renal Insufficiency

1995
Nitric oxide improves membrane fluidity of erythrocytes in essential hypertension: An electron paramagnetic resonance investigation.
    Biochemical and biophysical research communications, 2000, Sep-07, Volume: 275, Issue:3

    Topics: Arginine; Blood Pressure; Calcimycin; Cell Membrane; Cyclic GMP; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Erythrocytes; Hemorheology; Humans; Hypertension; Membrane Fluidity; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Penicillamine; Spin Labels

2000
Estriol improves membrane fluidity of erythrocytes by the nitric oxide-dependent mechanism: an electron paramagnetic resonance study.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2001, Volume: 24, Issue:3

    Topics: Arginine; Cyclic GMP; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Erythrocyte Membrane; Estriol; Female; Humans; In Vitro Techniques; Male; Membrane Fluidity; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine

2001
Electron paramagnetic resonance investigation on modulatory effect of 17beta-estradiol on membrane fluidity of erythrocytes in postmenopausal women.
    Arteriosclerosis, thrombosis, and vascular biology, 2001, Volume: 21, Issue:8

    Topics: Aged; Arginine; Cyclic GMP; Electron Spin Resonance Spectroscopy; Erythrocytes; Estradiol; Female; Humans; Hypertension; In Vitro Techniques; Membrane Fluidity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Postmenopause; S-Nitroso-N-Acetylpenicillamine

2001
Localization and role of nitric oxide synthase and endogenous nitric oxide synthase inhibitors in the rabbit lower urinary tract.
    The Journal of urology, 2002, Volume: 167, Issue:5

    Topics: Animals; Arginine; Culture Techniques; Enzyme Inhibitors; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rabbits; Urethra; Urinary Bladder

2002
Nitric oxide and angiogenesis.
    Circulation, 2002, May-07, Volume: 105, Issue:18

    Topics: Angiogenesis Inhibitors; Angiostatins; Animals; Arginine; Arteriosclerosis; Coronary Circulation; Dogs; Endothelium, Vascular; Matrix Metalloproteinases; Myocardial Ischemia; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Plasminogen

2002
Asymmetric dimethylarginine upregulates LOX-1 in activated macrophages: role in foam cell formation.
    American journal of physiology. Heart and circulatory physiology, 2004, Volume: 287, Issue:2

    Topics: Arginine; Cell Differentiation; Endothelium, Vascular; Enzyme Inhibitors; Foam Cells; Free Radical Scavengers; HL-60 Cells; Humans; Lipoproteins, LDL; Macrophages; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Receptors, Cell Surface; Receptors, LDL; RNA, Small Interfering; Umbilical Veins; Up-Regulation

2004
Changes in the dimeric state of neuronal nitric oxide synthase affect the kinetics of secretagogue-induced insulin response.
    Diabetes, 2004, Volume: 53, Issue:6

    Topics: Animals; Arginine; Carrier Proteins; Cell Line; Dimerization; Drosophila Proteins; Dyneins; Enzyme Inhibitors; Glucose; Indazoles; Insulin; Insulin Secretion; Kinetics; Male; Miconazole; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroarginine; Nitroprusside; Rats; Rats, Wistar; Surface Plasmon Resonance

2004
Homocysteine induces oxidative stress by uncoupling of NO synthase activity through reduction of tetrahydrobiopterin.
    Free radical biology & medicine, 2004, Jun-15, Volume: 36, Issue:12

    Topics: Antioxidants; Arginine; Ascorbic Acid; Biopterins; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Ethidium; Fluorescent Dyes; Homocysteine; Humans; L-Lactate Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Pterins; Reactive Nitrogen Species; Superoxides; Thrombin; Time Factors

2004
Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice: involvement of renin-angiotensin system and oxidative stress.
    Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:9

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Coronary Disease; Enzyme Induction; Homocysteine; Imidazoles; Infusion Pumps, Implantable; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcirculation; Myocardium; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Olmesartan Medoxomil; omega-N-Methylarginine; Oxidative Stress; Peptidyl-Dipeptidase A; Renin-Angiotensin System; Superoxides; Tetrazoles; Thiazepines

2004
A calcium channel blocker, benidipine, improves cell membrane fluidity in human subjects via a nitric oxide-dependent mechanism. An electron paramagnetic resonance investigation.
    American journal of hypertension, 2004, Volume: 17, Issue:12 Pt 1

    Topics: Aged; Arginine; Calcium Channel Blockers; Cell Membrane; Cyclic GMP; Dihydropyridines; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Erythrocytes; Female; Hemorheology; Humans; Male; Membrane Fluidity; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Viscosity

2004
Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis.
    Circulation, 2005, Mar-22, Volume: 111, Issue:11

    Topics: Amidohydrolases; Animals; Arginine; Enzyme Induction; Female; Hindlimb; Humans; Ischemia; Laser-Doppler Flowmetry; Mice; Mice, Transgenic; Microspheres; Muscle, Skeletal; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Prostheses and Implants; Recombinant Fusion Proteins

2005
L-NAME- and ADMA-induced sympathetic neural activation in conscious rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2006, Volume: 290, Issue:3

    Topics: Animals; Arginine; Baroreflex; Consciousness; Female; Kidney; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Sinoatrial Node; Sympathectomy; Sympathetic Nervous System

2006
Reduced nitric oxide concentration in the renal cortex of streptozotocin-induced diabetic rats: effects on renal oxygenation and microcirculation.
    Diabetes, 2005, Volume: 54, Issue:11

    Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Kidney Cortex; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Oxygen; Rats; Rats, Inbred WF; Renal Circulation

2005
A role for asymmetric dimethylarginine in the pathophysiology of portal hypertension in rats with biliary cirrhosis.
    Hepatology (Baltimore, Md.), 2005, Volume: 42, Issue:6

    Topics: Acetylcholine; Animals; Arginine; Hypertension, Portal; Liver; Liver Cirrhosis, Biliary; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Thioacetamide; Vasodilation

2005
Effect of L-arginine on asymmetric dimethylarginine (ADMA) or homocysteine-accelerated endothelial cell aging.
    Biochemical and biophysical research communications, 2006, Jul-07, Volume: 345, Issue:3

    Topics: Aging; Arginine; Cells, Cultured; Cellular Senescence; Endothelial Cells; Endothelium, Vascular; Homocysteine; Humans; NG-Nitroarginine Methyl Ester; Oxidative Stress; Telomerase; Time Factors

2006
Oral administration of both tetrahydrobiopterin and L-arginine prevents endothelial dysfunction in rats with chronic renal failure.
    Journal of cardiovascular pharmacology, 2007, Volume: 49, Issue:3

    Topics: Acetylcholine; Administration, Oral; Animals; Aorta; Arginine; Biopterins; Blood Pressure; Calcimycin; Drug Synergism; Drug Therapy, Combination; Endothelium, Vascular; Kidney Failure, Chronic; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxides

2007
Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals.
    American journal of physiology. Renal physiology, 2008, Volume: 294, Issue:2

    Topics: Animals; Arginine; Blood Pressure; Disease Models, Animal; Diuresis; Enzyme Inhibitors; Hydronephrosis; Hypertension; Indazoles; Kidney; Kidney Cortex; Kidney Tubules, Proximal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Sodium Chloride, Dietary; Ureteral Obstruction

2008
Effect of aspirin on high glucose-induced senescence of endothelial cells.
    Chinese medical journal, 2009, Dec-20, Volume: 122, Issue:24

    Topics: Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Aspirin; Caveolin 1; Cells, Cultured; Cellular Senescence; Chromatography, High Pressure Liquid; Endothelial Cells; Flow Cytometry; Glucose; Humans; Immunoblotting; Immunoprecipitation; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Propane; Reactive Oxygen Species

2009
Asymmetric dimethylarginine (ADMA) induces chronic kidney disease through a mechanism involving collagen and TGF-β1 synthesis.
    The Journal of pathology, 2011, Volume: 223, Issue:1

    Topics: Animals; Arginine; Collagen; Endothelin-1; Enzyme Inhibitors; Fibrosis; Gene Expression Regulation; Hypertension; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Renal Insufficiency, Chronic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta1

2011
Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.
    Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:7

    Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Cardiovascular Diseases; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Female; Genotype; Hypertension; Infusion Pumps, Implantable; Male; Mice; Mice, 129 Strain; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phenotype; Risk Factors; RNA Interference; Substrate Specificity; Time Factors; Transfection

2011
Stimulus-specific blockade of nitric oxide-mediated dilatation by asymmetric dimethylarginine (ADMA) and monomethylarginine (L-NMMA) in rat aorta and carotid artery.
    European journal of pharmacology, 2011, Dec-30, Volume: 673, Issue:1-3

    Topics: Animals; Aorta; Arginine; Carotid Arteries; Female; Male; Naphthyridines; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Phenylephrine; Pyrimidines; Rats; Rats, Wistar; Superoxide Dismutase; Vasodilation

2011
Nitric oxide synthase, ADMA, SDMA, and nitric oxide activity in the paraventricular nucleus throughout the etiology of renal wrap hypertension.
    American journal of physiology. Heart and circulatory physiology, 2012, Jun-01, Volume: 302, Issue:11

    Topics: Animals; Arginine; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Hypertension, Renal; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley

2012
Dimethylarginine dimethylaminohydrolase 1 regulates nerve growth factor-promoted differentiation of PC12 cells in a nitric oxide-dependent but asymmetric dimethylargenine-independent manner.
    Journal of neuroscience research, 2012, Volume: 90, Issue:6

    Topics: Amidohydrolases; Analysis of Variance; Animals; Arginine; Cell Differentiation; Enzyme Inhibitors; Microtubule-Associated Proteins; Nerve Growth Factor; Neurites; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; PC12 Cells; Rats; RNA, Messenger; Transfection

2012
Impairment of the extrusion transporter for asymmetric dimethyl-L-arginine: a novel mechanism underlying vasospastic angina.
    Biochemical and biophysical research communications, 2012, Jun-29, Volume: 423, Issue:2

    Topics: Adult; Angina Pectoris; Arginine; Blood Platelets; Coronary Vasospasm; Endothelium, Vascular; Enzyme Inhibitors; Humans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Superoxides

2012
Mechanism of cellular oxidation stress induced by asymmetric dimethylarginine.
    International journal of molecular sciences, 2012, Volume: 13, Issue:6

    Topics: Arginine; Biopterins; Enzyme Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; Lysine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress

2012
Nitric oxide in afferent arterioles after uninephrectomy depends on extracellular L-arginine.
    American journal of physiology. Renal physiology, 2013, Apr-15, Volume: 304, Issue:8

    Topics: Angiotensin II; Animals; Arginine; Arterioles; Blood Pressure; Body Weight; Enzyme Inhibitors; Extracellular Space; Glomerular Filtration Rate; Homeostasis; Male; Nephrectomy; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Rats; Rats, Wistar; Renal Circulation; Vasoconstrictor Agents

2013
Renoprotective effects of melatonin in young spontaneously hypertensive rats with L-NAME.
    Pediatrics and neonatology, 2014, Volume: 55, Issue:3

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Amidohydrolases; Animals; Antioxidants; Arginine; Blood Pressure; Deoxyguanosine; Humans; Hypertension; Hypertension, Renal; Kidney; Male; Melatonin; Nephritis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR

2014
Asymmetric dimethylarginine does not inhibit arginase activity and is pro-proliferative in pulmonary endothelial cells.
    Clinical and experimental pharmacology & physiology, 2014, Volume: 41, Issue:7

    Topics: Animals; Arginase; Arginine; Cattle; Cell Proliferation; Endothelial Cells; Lung; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Substrate Specificity; Urea

2014
Possible role of nitric oxide (NO) in the regulation of gender related differences in stress induced anxiogenesis in rats.
    Nitric oxide : biology and chemistry, 2014, Dec-01, Volume: 43

    Topics: Androstenedione; Animals; Anxiety; Arginine; Behavior, Animal; Brain; Enzyme Inhibitors; Female; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Sex Factors; Stress, Physiological

2014
ADMA, homocysteine and redox status improvement affected by 7-nitroindazole in spontaneously hypertensive rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 106

    Topics: Animals; Aorta; Arginine; Biomarkers; Disease Models, Animal; Enzyme Inhibitors; Heart Ventricles; Homocysteine; Hypertension; Indazoles; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidation-Reduction; Rats, Inbred SHR

2018
The protective effects of polysaccharide extract from Xin-Ji-Er-Kang formula on Ang II-induced HUVECs injury, L-NAME-induced hypertension and cardiovascular remodeling in mice.
    BMC complementary and alternative medicine, 2019, Jun-13, Volume: 19, Issue:1

    Topics: Angiotensin II; Animals; Aorta; Arginine; Blood Pressure; Cytokines; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Endothelial Cells; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Hypertension; Inflammation; Male; Malondialdehyde; Mice; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phytotherapy; Superoxide Dismutase; Vascular Remodeling

2019
The investigation of antioxidant and anti-inflammatory potentials of apitherapeutic agents on heart tissues in nitric oxide synthase inhibited rats via Nω-nitro-L-arginine methyl ester.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2021, Jan-02, Volume: 43, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arginine; Aryldialkylphosphatase; Blood Pressure; Caffeic Acids; Free Radical Scavengers; Male; Myocardium; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidants; Oxidative Stress; Phenylethyl Alcohol; Pollen; Propolis; Rats; Rats, Sprague-Dawley

2021