n,n-dimethylarginine has been researched along with losartan in 12 studies
| Studies (n,n-dimethylarginine) | Trials (n,n-dimethylarginine) | Recent Studies (post-2010) (n,n-dimethylarginine) | Studies (losartan) | Trials (losartan) | Recent Studies (post-2010) (losartan) |
|---|---|---|---|---|---|
| 2,216 | 228 | 1,221 | 7,231 | 1,245 | 2,118 |
| Protein | Taxonomy | n,n-dimethylarginine (IC50) | losartan (IC50) |
|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | 9.01 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 2.882 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.019 | |
| Atrial natriuretic peptide receptor 3 | Homo sapiens (human) | 0.0018 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.019 | |
| Type-1A angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0247 | |
| Type-1B angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0234 | |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | 0.0032 | |
| Type-1 angiotensin II receptor | Homo sapiens (human) | 0.047 | |
| Type-1 angiotensin II receptor | Oryctolagus cuniculus (rabbit) | 0.025 | |
| Type-2 angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0118 | |
| Type-2 angiotensin II receptor | Homo sapiens (human) | 0.019 | |
| Platelet glycoprotein VI | Homo sapiens (human) | 4 | |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | 1.1481 | |
| Type-1 angiotensin II receptor | Cavia porcellus (domestic guinea pig) | 0.018 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 0.2884 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (58.33) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, BM; Tao, LJ; Xiong, Y; Zhang, WR | 1 |
| Chen, MF; Sun, ZL; Xie, QY; Yang, TL | 1 |
| Li, D; Xia, K; Yang, TL; Zhao, ZY | 1 |
| Chen, MF; Li, YJ; Luo, BL; Wang, YJ; Xie, XM; Yang, TL; Zhang, XH | 1 |
| Deng, HW; Jiang, DJ; Li, D; Li, NS; Li, YJ; Luo, D; Wang, S; Xia, K | 1 |
| Koller, A; Lotz, G; Racz, A; Veresh, Z | 1 |
| Chen, MF; Li, YJ; Lou, B; Xie, XM; Yang, TL | 1 |
| Ahn, JS; Cho, JH; Choi, JY; Hyun, SH; Kim, CD; Kim, YL; Oh, EJ; Oh, SH; Park, SH; Ryu, HM; Yoon, SH | 1 |
| Hsu, CN; Huang, LT; Lee, CT; Tain, YL | 1 |
| Cerne, D; Drevensek, G; Janic, M; Jerin, A; Lunder, M; Marc, J; Sabovic, M; Skitek, M | 1 |
| Jiao, PL; Li, JK; Liu, B; Sun, JC; Tan, X; Wang, WZ; Wang, YK; Wu, ZT | 1 |
| Ge, LJ; Peng, XD; Sun, JC; Tan, X; Wang, WZ; Yang, RH | 1 |
1 trial(s) available for n,n-dimethylarginine and losartan
| Article | Year |
|---|---|
[Changes of serum asymmetric dimethylarginine in essential hypertension before and after the treatment].
Topics: Adult; Aged; Antihypertensive Agents; Arginine; Enalapril; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase | 2005 |
11 other study(ies) available for n,n-dimethylarginine and losartan
| Article | Year |
|---|---|
[Protective effect of losartan on injury induced by ox-LDL in endothelial cells and the relationship with asymmetric dimethylarginine].
Topics: Amidohydrolases; Arginine; Cells, Cultured; Endothelium, Vascular; Humans; L-Lactate Dehydrogenase; Lipoproteins, LDL; Losartan; Nitric Oxide; Protective Agents; Umbilical Veins | 2006 |
[Effect of asymmetric dimethylarginine on platelet-aggregation and losartan intervention in spontaneous hypertensive rat models].
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Arginine; Hypertension; Losartan; Male; Platelet Aggregation; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2006 |
Role of asymmetric dimethylarginine in inflammatory reactions by angiotensin II.
Topics: Amidohydrolases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Arginine; Cell Adhesion; Cells, Cultured; Culture Media, Conditioned; Endothelial Cells; Endothelium, Vascular; Gene Expression Regulation; Humans; Interleukin-8; Losartan; Monocytes; NF-kappa B; Nitrates; Nitric Oxide; Nitrites; Protein-Arginine N-Methyltransferases; Reactive Oxygen Species; Receptors, Interleukin-8B; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha; Umbilical Veins; Vasculitis; Vasodilation | 2007 |
Reduction of asymmetric dimethylarginine involved in the cardioprotective effect of losartan in spontaneously hypertensive rats.
Topics: Animals; Arginine; Blood Pressure; Hypertension; Losartan; Male; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation | 2007 |
ADMA impairs nitric oxide-mediated arteriolar function due to increased superoxide production by angiotensin II-NAD(P)H oxidase pathway.
Topics: Acetophenones; Angiotensin II; Animals; Arginine; Arterioles; Enzyme Inhibitors; Losartan; Male; Muscle, Skeletal; NADPH Oxidases; Nitric Oxide; Oxidative Stress; Quinapril; Rats; Rats, Wistar; Signal Transduction; Superoxides; Tetrahydroisoquinolines; Vasoconstriction; Vasodilation | 2008 |
Losartan inhibits monocytic adhesion induced by ADMA via downregulation of chemokine receptors in monocytes.
Topics: Arginine; Cell Adhesion; Cells, Cultured; Chemokine CCL2; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Humans; Interleukin-8; Losartan; Monocytes; NF-kappa B; Receptors, Chemokine; RNA, Messenger; Time Factors | 2009 |
Effects of losartan and pentoxifylline on renal dimethylarginine dimethylaminohydrolase-1 expression in proteinuric nephropathy.
Topics: Acetylglucosaminidase; Albuminuria; Amidohydrolases; Angiotensin II Type 1 Receptor Blockers; Animals; Arginine; Cell Line; Free Radical Scavengers; Kidney Tubules, Proximal; Losartan; Oxidative Stress; Pentoxifylline; Rats; Reactive Oxygen Species | 2013 |
Aliskiren in early postnatal life prevents hypertension and reduces asymmetric dimethylarginine in offspring exposed to maternal caloric restriction.
Topics: Amides; Angiotensin-Converting Enzyme 2; Animals; Animals, Newborn; Arginine; Blood Pressure; Blotting, Western; Body Weight; Caloric Restriction; Female; Fumarates; Gene Expression Regulation; Histone Deacetylases; Hypertension; Losartan; Male; Peptidyl-Dipeptidase A; Rats, Sprague-Dawley | 2015 |
The "Rise-Peak-Fall" Pattern of Time Dependency of the Cardiovascular Pleiotropic Effects of Treatment With Low-dose Atorvastatin, Losartan, and a Combination Thereof in Rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Arginine; Atorvastatin; Cardiovascular System; Carrier Proteins; CD40 Antigens; Coronary Circulation; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isolated Heart Preparation; Losartan; Male; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Rats, Wistar; Time Factors; Vasodilation | 2016 |
The asymmetric dimethylarginine-mediated inhibition of nitric oxide in the rostral ventrolateral medulla contributes to regulation of blood pressure in hypertensive rats.
Topics: Amidohydrolases; Angiotensin II; Animals; Arginine; Blood Pressure; Heart Rate; Kidney; Losartan; Male; Medulla Oblongata; Nitric Oxide; omega-N-Methylarginine; Protein-Arginine N-Methyltransferases; Rats, Inbred WKY; Rats, Sprague-Dawley; Sympathetic Nervous System | 2017 |
Interleukin enhancement binding factor 3 inhibits cardiac hypertrophy by targeting asymmetric dimethylarginine-nitric oxide.
Topics: Amidohydrolases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arginine; Cardiomegaly; Down-Regulation; Gene Knockdown Techniques; Losartan; Male; Myocytes, Cardiac; Nitric Oxide; Nuclear Factor 90 Proteins; Rats, Sprague-Dawley | 2019 |