Compounds > n,n-dimethylarginine
Page last updated: 2024-09-03

n,n-dimethylarginine and indomethacin

n,n-dimethylarginine has been researched along with indomethacin in 4 studies

Compound Research Comparison

Studies
(n,n-dimethylarginine)		Trials
(n,n-dimethylarginine)		Recent Studies (post-2010)
(n,n-dimethylarginine)		Studies
(indomethacin)		Trials
(indomethacin)		Recent Studies (post-2010) (indomethacin)
2,2162281,22129,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyn,n-dimethylarginine (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Henrion, D; Lévy, BI; Loufrani, L; Matrougui, K1
Jiang, DJ; Li, YJ; Peng, J; Wang, L; Zhang, Z; Zhou, Y1
Flyvbjerg, A; Jensen, JB; Kirkeby, HJ; Kun, A; Schjørring, O; Simonsen, U1
Abo-Saif, AA; Mohamed, WR; Mohamed, YT; Naguib, IA1

Other Studies

4 other study(ies) available for n,n-dimethylarginine and indomethacin

ArticleYear
High NaCl intake decreases both flow-induced dilation and pressure-induced myogenic tone in resistance arteries from normotensive rats: involvement of cyclooxygenase-2.
    Pharmacology & toxicology, 2001, Volume: 89, Issue:4

    Topics: Animals; Arginine; Blood Pressure; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Endothelium, Vascular; Indomethacin; Isoenzymes; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred WKY; Regional Blood Flow; Sodium Chloride, Dietary; Sulfonamides; Vasodilation

2001
Role of endogenous nitric oxide synthase inhibitor in gastric mucosal injury.
    Canadian journal of physiology and pharmacology, 2008, Volume: 86, Issue:3

    Topics: Amidohydrolases; Animals; Arginine; Campylobacter jejuni; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Ethanol; Gastric Acid; Gastric Mucosa; Helicobacter pylori; Humans; Indomethacin; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Stomach Diseases; Tumor Necrosis Factor-alpha

2008
Flow-evoked vasodilation is blunted in penile arteries from Zucker diabetic fatty rats.
    The journal of sexual medicine, 2012, Volume: 9, Issue:7

    Topics: Animals; Arginine; Arteries; Cyclooxygenase Inhibitors; Indomethacin; Male; Myography; Nitric Oxide Synthase; Penis; Peptides; Potassium Channels, Calcium-Activated; Rats; Rats, Zucker; Vasodilation

2012
Protective effects of perindopril against indomethacin-induced gastric mucosal damage through modulation of DDAH-1/ADMA and ACE-2/ANG-(1-7) signaling pathways.
    Drug and chemical toxicology, 2022, Volume: 45, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cyclooxygenase 2; Indomethacin; Pantoprazole; Perindopril; Prostaglandins E; Rats; Signal Transduction; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2022