Page last updated: 2024-09-03

n,n-dimethylarginine and folic acid

n,n-dimethylarginine has been researched along with folic acid in 24 studies

Compound Research Comparison

Studies
(n,n-dimethylarginine)
Trials
(n,n-dimethylarginine)
Recent Studies (post-2010)
(n,n-dimethylarginine)
Studies
(folic acid)
Trials
(folic acid)
Recent Studies (post-2010) (folic acid)
2,2162281,22130,0011,94510,195

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's14 (58.33)29.6817
2010's10 (41.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Arakawa, N; Bode-Böger, SM; Böger, RH; Frölich, JC; Hornig, B; Schwedhelm, E; Sydow, K; Tsikas, D1
Chan, JC; Chan, NN; Chan, WB1
Aukrust, P; Haugstad, TS; Holm, T; Holven, KB; Nenseter, MS; Ose, L1
Hedner, T; Hultberg, B; Jonasson, TF; Ohlin, H1
Kurabayashi, M; Morita, H; Nagai, R; Nakamura, T; Saito, Y1
Brouwer, CB; Rauwerda, JA; Smulders, YM; Spoelstra-de Man, AM; Stehouwer, CD; Teerlink, T1
Branca, F; Bugel, S; Dahlman-Wright, K; Dierkes, J; Ferrari, M; Hall, WL; Hallund, J; Huebner, U; Koebnick, C; Nilsson, M; Reimann, M; Vafeiadou, K; Williams, CM1
Blouet, C; Daré, S; Hammiche, A; Huneau, JF; Mariotti, F; Tomé, D1
Jehlicka, P; Mayer, O; Racek, J; Siala, K; Stožický, F; Trefil, L; Varvařovská, J1
Lentz, SR; Rodionov, RN1
Arning, E; Bottiglieri, T; Cooke, JP; Dayal, S; Faraci, FM; Kimoto, M; Lentz, SR; Murry, DJ; Rodionov, RN1
Kiefte-de Jong, JC; Nanayakkara, PW; Olthof, MR; Smulders, YM; Stehouwer, CD; Teerlink, T; ter Wee, PM; Twisk, JW; van Guldener, C; van Ittersum, FJ1
Blom, H; Carmichael, SL; Finnell, RH; Shaw, GM; Ueland, PM; Vollset, SE; Yang, W1
Bek, S; Cakir, E; Gökçil, Z; Odabaşi, Z; Oz, O1
Dohi, Y; Ito, A; Itoh, T; Kajikuri, J; Koyama, K; Kumagai, H; Nakamura, H; Nishio, T; Ohte, N; Sano, A; Yamamoto, J1
Ardic, I; Celik, A; Ceyhan, K; Erdem, S; Kadi, H; Kalay, N; Kaya, MG; Koc, F; Onalan, O; Ozbek, K; Sahin, S; Taner, A; Yarlioglues, M1
Aydogdu, SD; Colak, O; Dinleyici, EC; Ozdemir, O; Yakut, A; Yarar, C1
Elmadfa, I; Fabian, E; Kickinger, A; Wagner, KH1
Li, X; Ma, JP; Wang, CX; Wang, L; Wu, CJ; Xia, XS1
Bleie, O; Borgeraas, H; Løland, KH; Nordrehaug, JE; Nygård, O; Strand, E; Svardal, A; Ueland, PM1
Li, X; Ma, JP; Wang, JZ; Wang, L; Wu, CJ; Xia, XS1
Das, UN1
Boruc, O; Bruce-Cobbold, C; Caplin, B; Cutillas, P; Dormann, D; Faull, P; Grossman, RC; Khadayate, S; Leiper, J; Mas, VR; Nitsch, DD; Norman, JT; Tomlinson, JA; Wang, Z; Wheeler, DC; Wilcox, CS1
Hinojosa-Cruz, JC; Leaños-Miranda, A; López-Alarcón, M; Martínez-Basila, A; Montalvo-Velarde, I; Vital-Reyes, VS1

Reviews

2 review(s) available for n,n-dimethylarginine and folic acid

ArticleYear
[Involvement of homocysteine in the pathogenesis of hypertension and hypertensive target-organ damage].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 3

    Topics: Arginine; Arteriosclerosis; Biopterins; Cell Division; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Hypertension; Insulin Resistance; Muscle, Smooth, Vascular; Nitric Oxide; Oxidative Stress; Risk Factors

2004
Nutritional factors in the prevention and management of coronary artery disease and heart failure.
    Nutrition (Burbank, Los Angeles County, Calif.), 2015, Volume: 31, Issue:2

    Topics: Alprostadil; Anti-Inflammatory Agents; Arginine; CD59 Antigens; Coronary Artery Disease; Diabetes Mellitus, Type 2; Epoprostenol; Fatty Acids, Essential; Fatty Acids, Unsaturated; Female; Folic Acid; Heart Failure; Humans; Hypertension; Lipoxins; Magnesium; Male; Middle Aged; Nitric Oxide; Nutritional Status; Serum Albumin; Vasodilation; Vitamin B 12; Vitamin B 6

2015

Trials

10 trial(s) available for n,n-dimethylarginine and folic acid

ArticleYear
ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins.
    Cardiovascular research, 2003, Volume: 57, Issue:1

    Topics: Aged; Analysis of Variance; Arginine; Arterial Occlusive Diseases; Double-Blind Method; Female; Folic Acid; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nitric Oxide Synthase; Oxidative Stress; Peripheral Vascular Diseases; Vitamin B 12; Vitamin B 6; Vitamins

2003
Folic acid treatment reduces elevated plasma levels of asymmetric dimethylarginine in hyperhomocysteinaemic subjects.
    The British journal of nutrition, 2003, Volume: 89, Issue:3

    Topics: Adult; Aged; Arginine; Biomarkers; Dietary Supplements; Enzyme Inhibitors; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nitric Oxide Synthase

2003
Hyperhomocysteinaemia is not associated with increased levels of asymmetric dimethylarginine in patients with ischaemic heart disease.
    European journal of clinical investigation, 2003, Volume: 33, Issue:7

    Topics: Adult; Arginine; Female; Folic Acid; Humans; Hyperhomocysteinemia; Male; Middle Aged; Myocardial Ischemia; Nitric Oxide Synthase; Pyridoxine; Vitamin B 12

2003
No effect of B vitamins on ADMA levels in patients at increased cardiovascular risk.
    Clinical endocrinology, 2006, Volume: 64, Issue:5

    Topics: Adolescent; Adult; Arginine; Atherosclerosis; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Female; Folic Acid; Humans; Hyperhomocysteinemia; Linear Models; Male; Middle Aged; Pyridoxine; Risk Factors; Time Factors; Treatment Failure; Vitamin B Complex

2006
Asymmetric dimethylarginine and the effect of folate substitution in children with familial hypercholesterolemia and diabetes mellitus type 1.
    Physiological research, 2009, Volume: 58, Issue:2

    Topics: Adolescent; Anticholesteremic Agents; Arginine; Azetidines; Biomarkers; Child; Diabetes Mellitus, Type 1; Drug Therapy, Combination; Endothelium, Vascular; Ezetimibe; Female; Folic Acid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Lipoproteins, LDL; Male; Risk Factors; Ultrasonography; Vitamin B Complex

2009
Randomized placebo-controlled trial assessing a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on plasma asymmetric dimethylarginine concentration in mild to moderate CKD.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2009, Volume: 53, Issue:1

    Topics: Adult; Aged; Anticholesteremic Agents; Arginine; Carotid Arteries; Chronic Disease; Creatinine; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Kidney Diseases; Lipoproteins, LDL; Male; Middle Aged; Pravastatin; Vitamin B 12; Vitamin B 6; Vitamin E

2009
Randomized controlled trial of the effect of short-term coadministration of methylcobalamin and folate on serum ADMA concentration in patients receiving long-term hemodialysis.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2010, Volume: 55, Issue:6

    Topics: Administration, Oral; Aged; Arginine; Cardiovascular Diseases; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Injections, Intravenous; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Risk Factors; Vitamin B 12; Vitamin B Complex

2010
[Impact of adding folic acid, vitamin B(12) and probucol to standard antihypertensive medication on plasma homocysteine and asymmetric dimethylarginine levels of essential hypertension patients].
    Zhonghua xin xue guan bing za zhi, 2012, Volume: 40, Issue:12

    Topics: Aged; Antihypertensive Agents; Arginine; Female; Folic Acid; Homocysteine; Humans; Hypertension; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type III; Plasma; Probucol; Vitamin B 12; Vitamin B Complex; Vitamins

2012
The association between progression of atherosclerosis and the methylated amino acids asymmetric dimethylarginine and trimethyllysine.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Adenosine; Aged; Arginine; Coronary Angiography; Coronary Artery Disease; Disease Progression; Ethionine; Female; Folic Acid; Follow-Up Studies; Humans; Lysine; Male; Methylation; Middle Aged; Treatment Outcome; Vitamin B 12; Vitamin B 6; Vitamin B Complex

2013
Supplementation of folic acid and vitamin B₁₂ reduces plasma levels of asymmetric dimethylarginine in patients with acute ischemic stroke.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2014, Volume: 21, Issue:9

    Topics: Aged; Arginine; Blood Chemical Analysis; Brain Ischemia; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Stroke; Time Factors; Treatment Outcome; Vitamin B 12

2014

Other Studies

12 other study(ies) available for n,n-dimethylarginine and folic acid

ArticleYear
Reduction of total homocysteine levels by oral folic acid fails to improve endothelial function in children with chronic renal failure.
    Circulation, 2003, Jan-07, Volume: 107, Issue:1

    Topics: Administration, Oral; Arginine; Child; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Vasodilation

2003
Evidence for associations between common polymorphisms of estrogen receptor beta gene with homocysteine and nitric oxide.
    Climacteric : the journal of the International Menopause Society, 2006, Volume: 9, Issue:3

    Topics: Aged; Arginine; Body Mass Index; Cardiovascular Diseases; Cross-Sectional Studies; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Folic Acid; Genetic Variation; Genotype; Homocysteine; Humans; Linkage Disequilibrium; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Polymorphism, Single Nucleotide; Postmenopause; Risk Factors; Vitamin B 12

2006
Medium-term methionine supplementation increases plasma homocysteine but not ADMA and improves blood pressure control in rats fed a diet rich in protein and adequate in folate and choline.
    European journal of nutrition, 2006, Volume: 45, Issue:7

    Topics: Adaptation, Physiological; Animals; Area Under Curve; Arginine; Blood Pressure; Choline; Dietary Proteins; Dietary Supplements; Folic Acid; Homocysteine; Male; Methionine; Methylation; Nitric Oxide; Random Allocation; Rats; Rats, Wistar; Time Factors

2006
The homocysteine paradox.
    Arteriosclerosis, thrombosis, and vascular biology, 2008, Volume: 28, Issue:6

    Topics: Animals; Arginine; Cardiovascular Diseases; Cystatin C; Cystatins; Disease Models, Animal; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Diseases; Risk Factors; Vitamin B 12; Vitamin B 6

2008
Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:2

    Topics: Amidohydrolases; Animals; Arginine; Carotid Arteries; Cell Line; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; RNA, Messenger; Vasodilation; Vasodilator Agents

2008
Nested case-control study of one-carbon metabolites in mid-pregnancy and risks of cleft lip with and without cleft palate.
    Pediatric research, 2009, Volume: 66, Issue:5

    Topics: Adult; Arginine; Carbon; Case-Control Studies; Cleft Lip; Cleft Palate; Dietary Supplements; Female; Folic Acid; Humans; Maternal Age; Nutritional Sciences; Odds Ratio; Pregnancy; Vitamins

2009
Is asymmetric dimethylarginine responsible for the vascular events in patients under antiepileptic drug treatment?
    Epilepsy research, 2009, Volume: 87, Issue:1

    Topics: Adult; Anticonvulsants; Arginine; Arterial Occlusive Diseases; Carbamazepine; Drug Monitoring; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Statistics, Nonparametric; Valproic Acid; Vitamin B 12

2009
Relationship between L-arginine/asymmetric dimethylarginine, homocysteine, folic acid, vitamin B levels, and coronary artery ectasia.
    Coronary artery disease, 2010, Volume: 21, Issue:8

    Topics: Aged; Arginine; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Dilatation, Pathologic; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Prospective Studies; Turkey; Vitamin B Complex

2010
Serum asymmetric dimethylarginine (ADMA), homocysteine, vitamin B(12), folate levels, and lipid profiles in epileptic children treated with valproic acid.
    European journal of pediatrics, 2011, Volume: 170, Issue:7

    Topics: Adolescent; Anticonvulsants; Arginine; Biomarkers; Case-Control Studies; Child; Child, Preschool; Cholesterol; Cross-Sectional Studies; Drug Administration Schedule; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Triglycerides; Valproic Acid; Vitamin B 12; Vitamin B Complex

2011
Homocysteine and asymmetric dimethylarginine in relation to B vitamins in elderly people.
    Wiener klinische Wochenschrift, 2011, Volume: 123, Issue:15-16

    Topics: Aged; Aged, 80 and over; Arginine; Biological Availability; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Hypercholesterolemia; Male; Nitric Oxide; Nitric Oxide Synthase; Statistics as Topic; Vasodilation; Vitamin B 12; Vitamin B 6

2011
Reduced Renal Methylarginine Metabolism Protects against Progressive Kidney Damage.
    Journal of the American Society of Nephrology : JASN, 2015, Volume: 26, Issue:12

    Topics: Acute Kidney Injury; Adult; Allografts; Amidohydrolases; Animals; Arginine; Collagen Type I; Collagen Type I, alpha 1 Chain; Female; Folic Acid; Gene Expression; Glomerular Filtration Rate; Humans; Kidney Transplantation; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Nitric Oxide; RNA, Messenger; Transaminases; Ureteral Obstruction; Uromodulin

2015
Serial determinations of asymmetric dimethylarginine and homocysteine during pregnancy to predict pre-eclampsia: a longitudinal study.
    BJOG : an international journal of obstetrics and gynaecology, 2015, Volume: 122, Issue:12

    Topics: Adult; Arginine; Biomarkers; Body Mass Index; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Longitudinal Studies; Pre-Eclampsia; Predictive Value of Tests; Pregnancy; Risk Factors; United Kingdom; Vitamin B Complex; Vitamin B Deficiency

2015