Page last updated: 2024-09-03

n,n-dimethylarginine and cyclic gmp

n,n-dimethylarginine has been researched along with cyclic gmp in 41 studies

Compound Research Comparison

Studies (n,n-dimethylarginine)	Trials (n,n-dimethylarginine)	Recent Studies (post-2010) (n,n-dimethylarginine)	Studies (cyclic gmp)	Trials (cyclic gmp)	Recent Studies (post-2010) (cyclic gmp)
2,216	228	1,221	22,346	333	4,062

Protein Interaction Comparison

Protein	Taxonomy	cyclic gmp (IC50)
Phosphodiesterase	Bos taurus (cattle)	0.1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Homo sapiens (human)	2.4
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	Homo sapiens (human)	2.4

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (17.07)	18.2507
2000's	24 (58.54)	29.6817
2010's	10 (24.39)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Alexander, K; Bode-Böger, SM; Böger, RH; Frölich, JC; Junker, W; Thiele, W	1
Azuma, H; Hamasaki, H; Ishizaka, K; Masuda, H; Matsubara, O; Sato, J; Tamaoki, S	1
Alexander, K; Bode-Böger, SM; Böger, RH; Creutzig, A; Frölich, JC; Thiele, W	1
Azuma, H; Goto, M; Masuda, H; Tamaoki, S	1
Brand, R; Egberts, J; van den Bosch, N	1
Cartwright, JE; Holden, DP; Whitley, GS	1
Egberts, J; Soederhuizen, P; van den Bosch, N	1
Bode-Böger, SM; Böger, RH; Cooke, JP; Imaizumi, T; Matsuoka, H; Miyazaki, H; Okuda, S; Ueda, S; Usui, M	1
Johnstone, AP; Millatt, LJ; Nussey, SS; Whitley, GS	1
Kimura, K; Masuyama, Y; Nishio, I; Tsuda, K	1
Duan, J; Ikeda, H; Imaizumi, T; Katoh, A; Kawata, H; Murohara, T; Sasaki, K; Shintani, S; Yamamoto, N	1
Kimura, K; Masuyama, Y; Nishio, I; Shimamoto, Y; Tsuda, K	1
Kimura, K; Kinoshita, Y; Masuyama, Y; Nishio, I; Tsuda, K	1
Aso, T; Azuma, H; Beppu, M; Goto, M; Obayashi, S	1
Azuma, H; Goto, M; Kihara, K; Masuda, H; Okuno, T; Tsujii, T	1
Adimoolam, S; Asagami, T; Cooke, JP; Ito, A; Kimoto, M; Lin, KY; Reaven, GM; Tsao, PS; Tsuji, H	1
Chierchia, S; Fermo, I; Fragasso, G; Galluccio, E; Lucotti, P; Margonato, A; Monti, LD; Paroni, R; Piatti, P; Pozza, G; Setola, E	1
John, S; Schmieder, RE	1
Bode-Böger, SM; Fliser, D; Frölich, JC; Haller, H; Hoeper, MM; Impraim, B; Kielstein, JT; Simmel, S; Tsikas, D	1
Cooke, JP; Gao, SZ; Kledal, TN; Lin, KY; Mocarski, ES; Panchal, SN; Valantine, HA; Weis, M	1
Nishio, I; Tsuda, K	1
Akita, Y; Fujimoto, S; Koga, Y; Matsuishi, T; Nishioka, J; Povalko, N; Tanabe, Y; Yatsuga, S	1
Grdić, M; Huber, K; Maurer, G; Niessner, A; Penka, M; Richter, B; Simeon-Rudolf, V; Steiner, S; Strasser, B; Wojta, J; Ziegler, S; Zorn, G	1
Aso, T; Azuma, H; Ishibahshi, T; Ishizaka, M; Obayashi, S; Sakamoto, S	1
Cheng, Y; Jennings, LK; Ji, R; Sun, JZ; Yang, J; Zhang, C	1
Fisslthaler, B; Fleming, I; Leiper, JM; Torondel, B; Tsang, LY; Vallance, P; Wojciak-Stothard, B	1
Benndorf, R; Böger, RH; Förstermann, U; Kahl, L; Li, H; Lüneburg, N; Maas, R; Schwedhelm, E	1
Bai, YP; Chen, YR; Jiang, DJ; Li, YJ; Shi, RZ; Tang, ZY; Xiao, HB; Zhang, GG	1
Ali, O; Bauersachs, J; Bédard, E; Diller, GP; Gatzoulis, MA; Gibbs, JS; Hobbs, AJ; Howard, LS; Okonko, DO; Thum, T; van Eijl, S; Wharton, J; Wilkins, MR; Wort, SJ	1
Azuma, H; Hirata, Y; Imamura, M; Sakurada, M; Shichiri, M	1
Chen, Y; Gu, Q; Sheng, M; Xu, X; Zhang, X; Zheng, Z	1
Fleming, I; Ghofrani, HA; Grimminger, F; Leiper, J; Mayer, K; Pullamsetti, SS; Savai, R; Schaefer, MB; Schermuly, RT; Schudt, C; Seeger, W; Weissmann, N; Wilhelm, J	1
Chan, WP; Chirkov, YY; Heresztyn, T; Horowitz, JD; Leslie, S; Liberts, EA; Procter, N; Rajendran, S; Willoughby, SR	1
Bakr, A; Brandes, RP; Cooke, JP; Ghofrani, HA; Gierhardt, M; Grimminger, F; Hamada, F; Hemeida, R; Huang, N; Janssen, W; Pak, O; Schermuly, RT; Seeger, W; Sommer, N; Taye, A; Weissmann, N; Witzenrath, M	1
Dubois, O; Duluc, L; Iannone, L; Leiper, J; Rhodes, CJ; Wharton, J; Wilkins, MR; Wojciak-Stothard, B; Zhao, L	1
Chen, D; Fu, Q; Wang, JH; Zhang, H; Zhang, KQ	1
He, GW; Liu, Z; Lun, LM; Ning, CP; Wang, HW; Wang, J; Xuan, C; Zhang, BB; Zhao, JX	1
Diessel, S; Forst, T; Jahnke, J; Kapitza, C; Michelson, G	1
Chen, H; Jiang, N; Liu, Y; Mu, D; Song, J; Wang, M; Xia, M	1
Chen, Z; Cui, K; Liu, J; Luan, Y; Rao, K; Tang, Z; Wang, D; Wang, S; Wang, T	1
Fu, Q; Hu, LL; Tian, T; Zhang, H; Zhang, KQ	1

Reviews

1 review(s) available for n,n-dimethylarginine and cyclic gmp

Article	Year
Potential mechanisms of impaired endothelial function in arterial hypertension and hypercholesterolemia. Current hypertension reports, 2003, Volume: 5, Issue:3 Topics: Animals; Arginine; Biological Availability; Cyclic GMP; Endothelium, Vascular; Humans; Hypercholesterolemia; Hypertension; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Prognosis; Vasodilation	2003

Trials

6 trial(s) available for n,n-dimethylarginine and cyclic gmp

Article	Year
Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. Journal of the American College of Cardiology, 1998, Volume: 32, Issue:5 Topics: Aged; Aged, 80 and over; Alprostadil; Arginine; Arterial Occlusive Diseases; Blood Flow Velocity; Chronic Disease; Cyclic GMP; Double-Blind Method; Exercise Test; Female; Femoral Artery; Follow-Up Studies; Humans; Infusions, Intravenous; Intermittent Claudication; Leg; Male; Middle Aged; Nitrates; Nitric Oxide; Peripheral Vascular Diseases; Treatment Outcome; Ultrasonography, Doppler, Duplex; Vasodilation; Vasodilator Agents	1998
Acute intravenous L-arginine infusion decreases endothelin-1 levels and improves endothelial function in patients with angina pectoris and normal coronary arteriograms: correlation with asymmetric dimethylarginine levels. Circulation, 2003, Jan-28, Volume: 107, Issue:3 Topics: Angina Pectoris; Arginine; Blood Pressure; Coronary Angiography; Cyclic GMP; Endothelin-1; Endothelium, Vascular; Female; Forearm; Humans; Infusions, Intravenous; Insulin; Male; Middle Aged; Nitric Oxide; Regional Blood Flow; Syndrome	2003
Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans. Circulation, 2004, Jan-20, Volume: 109, Issue:2 Topics: Arginine; Cardiac Output; Cross-Over Studies; Cyclic GMP; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Hemodynamics; Humans; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Vascular Resistance	2004
L-arginine improves the symptoms of strokelike episodes in MELAS. Neurology, 2005, Feb-22, Volume: 64, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Amino Acids; Arginine; Cerebral Arteries; Child; Child, Preschool; Cholesterol; Cyclic GMP; Female; Headache; Humans; Male; MELAS Syndrome; Nitric Oxide; Paresis; Seizures; Stroke; Treatment Outcome; Vasodilation; Vision Disorders; Vomiting	2005
Ramipril sensitizes platelets to nitric oxide: implications for therapy in high-risk patients. Journal of the American College of Cardiology, 2012, Sep-04, Volume: 60, Issue:10 Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Arginine; Biomarkers; Blood Platelets; Cohort Studies; Cyclic GMP; Double-Blind Method; Drug Administration Schedule; Female; Guanylate Cyclase; Humans; Male; Malondialdehyde; Middle Aged; Nitric Oxide; Nitroprusside; Oxidative Stress; Platelet Aggregation; Ramipril; Thrombospondin 1	2012
Microvascular effects of the inhibition of dipeptidylpeptidase IV by linagliptin in nondiabetic hypertensive patients. Journal of hypertension, 2016, Volume: 34, Issue:2 Topics: Aged; Arginine; Arterial Pressure; C-Reactive Protein; Cyclic GMP; Cystatin C; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Female; Glycated Hemoglobin; Humans; Hypertension; Linagliptin; Male; Microvessels; Middle Aged; Regional Blood Flow; Retinal Vessels; Transforming Growth Factor beta1	2016

Other Studies

34 other study(ies) available for n,n-dimethylarginine and cyclic gmp

Article	Year
Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease. Circulation, 1997, Apr-15, Volume: 95, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Aging; Arginine; Arterial Occlusive Diseases; Cyclic GMP; Disease Progression; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Peripheral Vascular Diseases; Vasodilation	1997
Endogenous asymmetrical dimethylarginine and hypertension associated with puromycin nephrosis in the rat. British journal of pharmacology, 1998, Volume: 125, Issue:3 Topics: Animals; Arginine; Blood Pressure; Body Weight; Cyclic GMP; Endothelium; Glomerulosclerosis, Focal Segmental; Hypertension; Kidney; Male; Nitrous Oxide; Puromycin Aminonucleoside; Rats; Rats, Sprague-Dawley	1998
Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia. British journal of pharmacology, 1999, Volume: 126, Issue:1 Topics: Alloxan; Animals; Arginine; Blood Glucose; Body Weight; Carotid Arteries; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Hyperglycemia; Hyperplasia; In Vitro Techniques; Male; Nitric Oxide; omega-N-Methylarginine; Rabbits; Tunica Intima; Tunica Media; Weight Gain	1999
Nitric oxide metabolites, cyclic guanosine 3,5 monophosphate and dimethylarginines during and after uncomplicated pregnancies: a longitudinal study. European journal of obstetrics, gynecology, and reproductive biology, 1999, Volume: 82, Issue:1 Topics: Adult; Arginine; Chromatography, High Pressure Liquid; Creatinine; Cyclic GMP; Enzyme Inhibitors; Ethylenediamines; Female; Free Radical Scavengers; Humans; Immunoenzyme Techniques; Longitudinal Studies; Male; Nitrates; Nitric Oxide; Nitrites; Postpartum Period; Pregnancy; Reference Values; Sulfanilamides; Time Factors	1999
Hepatocyte growth factor regulates human trophoblast motility and invasion: a role for nitric oxide. British journal of pharmacology, 1999, Volume: 128, Issue:1 Topics: Arginine; Cell Division; Cell Line; Cell Movement; Cell Size; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Induction; Female; Fibrin; Hepatocyte Growth Factor; Humans; Integrins; Interleukin-1; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; RNA, Messenger; Transfection; Trophoblasts; Tumor Necrosis Factor-alpha	1999
Amniotic fluid nitric oxide metabolites, cyclic guanosine 3',5' monophosphate and dimethylarginine in alloimmunized pregnancies. European journal of obstetrics, gynecology, and reproductive biology, 1999, Volume: 85, Issue:2 Topics: Amniocentesis; Amniotic Fluid; Arginine; Blood Transfusion, Intrauterine; Creatinine; Cyclic GMP; Embryonic and Fetal Development; Erythroblastosis, Fetal; Female; Gestational Age; Humans; Infant, Newborn; Nitric Oxide; Nitrites; Pregnancy; Reference Values; Regression Analysis; Retrospective Studies; Rh Isoimmunization	1999
Is asymmetric dimethylarginine a novel marker of atherosclerosis? Circulation, 2000, Apr-11, Volume: 101, Issue:14 Topics: Arginine; Arteriosclerosis; Biomarkers; Carotid Arteries; Chromatography, High Pressure Liquid; Cyclic GMP; Enzyme Inhibitors; Humans; Nitrates; Nitric Oxide Synthase; Regression Analysis; Stereoisomerism; Tunica Intima	2000
Thyrocyte release of asymmetric dimethylarginine does not account for human thyrocyte inhibition of endothelial cell cyclic GMP. European journal of endocrinology, 2000, Volume: 142, Issue:5 Topics: Arginine; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide Synthase; Radioimmunoassay; Thyroid Gland; Umbilical Veins	2000
Nitric oxide improves membrane fluidity of erythrocytes in essential hypertension: An electron paramagnetic resonance investigation. Biochemical and biophysical research communications, 2000, Sep-07, Volume: 275, Issue:3 Topics: Arginine; Blood Pressure; Calcimycin; Cell Membrane; Cyclic GMP; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Erythrocytes; Hemorheology; Humans; Hypertension; Membrane Fluidity; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Penicillamine; Spin Labels	2000
Hypercholesterolemia inhibits angiogenesis in response to hindlimb ischemia: nitric oxide-dependent mechanism. Circulation, 2000, Nov-07, Volume: 102, Issue:19 Suppl 3 Topics: Administration, Oral; Animals; Arginine; Body Weight; Cholesterol, Dietary; Collateral Circulation; Cyclic GMP; Endothelium, Vascular; Hindlimb; Hypercholesterolemia; Immunohistochemistry; Ischemia; Laser-Doppler Flowmetry; Lipids; Male; Neovascularization, Physiologic; Nitrates; Nitric Oxide; Nitrites; Rats; Rats, Sprague-Dawley; Regional Blood Flow	2000
Estriol improves membrane fluidity of erythrocytes by the nitric oxide-dependent mechanism: an electron paramagnetic resonance study. Hypertension research : official journal of the Japanese Society of Hypertension, 2001, Volume: 24, Issue:3 Topics: Arginine; Cyclic GMP; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Erythrocyte Membrane; Estriol; Female; Humans; In Vitro Techniques; Male; Membrane Fluidity; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine	2001
Electron paramagnetic resonance investigation on modulatory effect of 17beta-estradiol on membrane fluidity of erythrocytes in postmenopausal women. Arteriosclerosis, thrombosis, and vascular biology, 2001, Volume: 21, Issue:8 Topics: Aged; Arginine; Cyclic GMP; Electron Spin Resonance Spectroscopy; Erythrocytes; Estradiol; Female; Humans; Hypertension; In Vitro Techniques; Membrane Fluidity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Postmenopause; S-Nitroso-N-Acetylpenicillamine	2001
Endogenous nitric oxide synthase inhibitors in endothelial cells, endothelin-1 within the vessel wall, and intimal hyperplasia in perimenopausal human uterine arteries. Journal of cardiovascular pharmacology, 2002, Volume: 39, Issue:2 Topics: Adult; Arginine; Arteries; Chromatography, High Pressure Liquid; Climacteric; Cyclic GMP; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hyperplasia; In Vitro Techniques; Middle Aged; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Tunica Intima; Tunica Media; Uterus	2002
Accumulated endogenous NOS inhibitors, decreased NOS activity, and impaired cavernosal relaxation with ischemia. American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:6 Topics: Animals; Arginine; Calcium; Carbachol; Cholinergic Agonists; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Endothelium, Vascular; Enzyme Inhibitors; Iliac Artery; Impotence, Vasculogenic; In Vitro Techniques; Ischemia; Male; Nitric Oxide Synthase; omega-N-Methylarginine; Penis; Rabbits; Vasoconstrictor Agents; Vasodilator Agents	2002
Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase. Circulation, 2002, Aug-20, Volume: 106, Issue:8 Topics: Amidohydrolases; Animals; Antioxidants; Aorta; Arginine; Cell Line; Cells, Cultured; Cyclic GMP; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Glucose; Humans; Male; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Oxidative Stress; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Superoxide Dismutase	2002
Cytomegalovirus infection impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine in transplant arteriosclerosis. Circulation, 2004, Feb-03, Volume: 109, Issue:4 Topics: Amidohydrolases; Arginine; Cardiovascular Diseases; Cells, Cultured; Coronary Angiography; Coronary Artery Disease; Cyclic GMP; Cytomegalovirus Infections; Endothelium, Vascular; Female; Heart Transplantation; Humans; Male; Middle Aged; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Risk Factors; Signal Transduction	2004
A calcium channel blocker, benidipine, improves cell membrane fluidity in human subjects via a nitric oxide-dependent mechanism. An electron paramagnetic resonance investigation. American journal of hypertension, 2004, Volume: 17, Issue:12 Pt 1 Topics: Aged; Arginine; Calcium Channel Blockers; Cell Membrane; Cyclic GMP; Dihydropyridines; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Erythrocytes; Female; Hemorheology; Humans; Male; Membrane Fluidity; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Viscosity	2004
Endurance training reduces circulating asymmetric dimethylarginine and myeloperoxidase levels in persons at risk of coronary events. Thrombosis and haemostasis, 2005, Volume: 94, Issue:6 Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Cyclic GMP; Exercise; Female; Humans; Male; Middle Aged; Peroxidase; Risk Factors	2005
Estrogen replacement effectively improves the accelerated intimal hyperplasia following balloon injury of carotid artery in the ovariectomized rats. Journal of cardiovascular pharmacology, 2006, Volume: 47, Issue:1 Topics: Animals; Arginine; Carotid Arteries; Catheterization; Cyclic GMP; Estradiol; Estrogen Replacement Therapy; Female; Follicle Stimulating Hormone; Hyperplasia; Immunohistochemistry; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Ovariectomy; Rats; Rats, Sprague-Dawley; Tunica Intima; Vasodilation	2006
L-arginine chlorination results in the formation of a nonselective nitric-oxide synthase inhibitor. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 318, Issue:3 Topics: Animals; Arginine; Cyclic GMP; Enzyme Inhibitors; Hypochlorous Acid; Male; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilation	2006
The ADMA/DDAH pathway is a critical regulator of endothelial cell motility. Journal of cell science, 2007, Mar-15, Volume: 120, Issue:Pt 6 Topics: Actin Cytoskeleton; Amidohydrolases; Animals; Arginine; cdc42 GTP-Binding Protein; Cell Movement; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytoskeleton; Endothelial Cells; Enzyme Activation; Focal Adhesions; Lung; Mice; Mice, Knockout; Neovascularization, Physiologic; rac1 GTP-Binding Protein; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; Signal Transduction; Stress Fibers; Swine	2007
Simultaneous assessment of endothelial function, nitric oxide synthase activity, nitric oxide-mediated signaling, and oxidative stress in individuals with and without hypercholesterolemia. Clinical chemistry, 2008, Volume: 54, Issue:2 Topics: Adolescent; Adult; Aged; Arginine; Cyclic GMP; Dinoprost; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Sex Factors	2008
Involvement of the endothelial DDAH/ADMA pathway in nitroglycerin tolerance: the role of ALDH-2. Life sciences, 2008, Mar-26, Volume: 82, Issue:13-14 Topics: Acetylcysteine; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Amidohydrolases; Arginine; Cell Line; Cyclic GMP; Drug Tolerance; Endothelial Cells; Humans; Lipid Peroxides; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitroglycerin; Oxidative Stress; Reactive Oxygen Species	2008
Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension. Circulation, 2008, Jun-10, Volume: 117, Issue:23 Topics: AC133 Antigen; Aged; Antigens, CD; Antigens, CD34; Arginine; Cells, Cultured; Cyclic GMP; Down Syndrome; Eisenmenger Complex; Endothelium, Vascular; Exercise; Female; Flow Cytometry; Glycoproteins; Hematopoietic Stem Cells; Humans; Hypertension, Pulmonary; Inflammation Mediators; Male; Middle Aged; Natriuretic Peptide, Brain; Peptides; Piperazines; Pulmonary Artery; Purines; Sildenafil Citrate; Stem Cells; Sulfones; Vascular Endothelial Growth Factor Receptor-2; Vasodilator Agents	2008
Nitric oxide upregulates dimethylarginine dimethylaminohydrolase-2 via cyclic GMP induction in endothelial cells. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 52, Issue:5 Topics: Amidohydrolases; Animals; Arginine; Carbazoles; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Male; Natriuretic Peptide, C-Type; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitro Compounds; omega-N-Methylarginine; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Up-Regulation	2008
PRMT-1 and DDAHs-induced ADMA upregulation is involved in ROS- and RAS-mediated diabetic retinopathy. Experimental eye research, 2009, Volume: 89, Issue:6 Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Cells, Cultured; Cyclic GMP; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelial Cells; Male; Protein-Arginine N-Methyltransferases; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Renin-Angiotensin System; Up-Regulation	2009
cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases. Circulation, 2011, Mar-22, Volume: 123, Issue:11 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amidohydrolases; Apoptosis; Arginine; Cell Proliferation; Cell Survival; Cells, Cultured; Cyclic GMP; Cytokines; Endothelial Cells; Hemodynamics; Humans; Hypertension, Pulmonary; Naphthyridines; Nitric Oxide; Phosphodiesterase Inhibitors; Promoter Regions, Genetic; Pulmonary Gas Exchange	2011
Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia. American journal of respiratory cell and molecular biology, 2013, Volume: 49, Issue:3 Topics: Amidohydrolases; Animals; Arginine; Blood Vessels; Cyclic GMP; Gene Expression; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Lung; Mice; Nitric Oxide; Nitroarginine; Organ Culture Techniques; Oxadiazoles; Signal Transduction; Vasoconstriction	2013
miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia. The Biochemical journal, 2014, Aug-15, Volume: 462, Issue:1 Topics: Amidohydrolases; Animals; Arginine; Cells, Cultured; Cyclic GMP; Endothelial Cells; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypoxia; Lung; Male; Mice; Mice, Transgenic; MicroRNAs; Myocytes, Smooth Muscle	2014
Effect of DDAH/ADMA/NOS regulation pathway on cavernae corporum cavernosorum rat penis of different age. Andrologia, 2016, Volume: 48, Issue:3 Topics: Amidohydrolases; Animals; Arginine; Cyclic GMP; Male; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Papaverine; Penis; Rats; Rats, Sprague-Dawley	2016
L-citrulline for protection of endothelial function from ADMA-induced injury in porcine coronary artery. Scientific reports, 2015, Jun-05, Volume: 5 Topics: Animals; Arginine; Cardiovascular Agents; Citrulline; Coronary Vessels; Cyclic GMP; Drug Evaluation, Preclinical; Endothelium, Vascular; Nitric Oxide Synthase Type III; Phosphorylation; Protein Processing, Post-Translational; Superoxides; Sus scrofa; Vascular System Injuries	2015
N-methylnicotinamide protects against endothelial dysfunction and attenuates atherogenesis in apolipoprotein E-deficient mice. Molecular nutrition & food research, 2016, Volume: 60, Issue:7 Topics: Acetylcholine; Amidohydrolases; Animals; Aorta; Arginine; Atherosclerosis; Cholesterol, Dietary; Cyclic GMP; Diet, High-Fat; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Niacinamide; Nitric Oxide; Promoter Regions, Genetic; Vasodilation	2016
Involvement of DDAH/ADMA/NOS/cGMP and COX-2/PTGIS/cAMP Pathways in Human Tissue Kallikrein 1 Protecting Erectile Function in Aged Rats. PloS one, 2017, Volume: 12, Issue:1 Topics: Aging; Amidohydrolases; Animals; Arginine; Cyclic AMP; Cyclic GMP; Cyclooxygenase 2; Cytochrome P-450 Enzyme System; Erectile Dysfunction; Humans; Intramolecular Oxidoreductases; Male; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Penile Erection; Penis; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Recombinant Proteins; RNA, Messenger; Signal Transduction; Tissue Kallikreins	2017
Probucol improves erectile function via Activation of Nrf2 and coordinates the HO-1 / DDAH / PPAR-γ/ eNOS pathways in streptozotocin-induced diabetic rats. Biochemical and biophysical research communications, 2018, 12-09, Volume: 507, Issue:1-4 Topics: Amidohydrolases; Animals; Arginine; Blood Glucose; Body Weight; Cyclic GMP; Diabetes Mellitus, Experimental; Erectile Dysfunction; Heme Oxygenase-1; Male; Malondialdehyde; NF-E2-Related Factor 2; Nitric Oxide Synthase Type III; PPAR gamma; Probucol; Rats, Sprague-Dawley; Signal Transduction; Streptozocin; Superoxide Dismutase	2018