n,n-dimethylarginine has been researched along with arginine in 2107 studies
Studies (n,n-dimethylarginine) | Trials (n,n-dimethylarginine) | Recent Studies (post-2010) (n,n-dimethylarginine) | Studies (arginine) | Trials (arginine) | Recent Studies (post-2010) (arginine) |
---|---|---|---|---|---|
2,216 | 228 | 1,221 | 46,388 | 1,688 | 11,176 |
Protein | Taxonomy | n,n-dimethylarginine (IC50) | arginine (IC50) |
---|---|---|---|
Cationic amino acid transporter 3 | Homo sapiens (human) | 283 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 8 (0.38) | 18.7374 |
1990's | 59 (2.80) | 18.2507 |
2000's | 716 (33.98) | 29.6817 |
2010's | 1187 (56.34) | 24.3611 |
2020's | 137 (6.50) | 2.80 |
Authors | Studies |
---|---|
Fast, W; Hong, L | 1 |
Calver, A; Collier, J; Leone, A; Moncada, S; Vallance, P | 3 |
Lazarides, E; Lin, JM; Wang, C | 1 |
Kakimoto, Y; Kondoh, K; Kotani, K; Sano, A; Ueno, S | 1 |
Kakimoto, Y; Kotani, K; Sano, A; Ueno, S | 1 |
Busch, H; Cook, RG; Lischwe, MA; Ochs, RL; Reddy, R; Reichlin, M; Tan, EM; Yeoman, LC | 1 |
Kimoto, M; Ogawa, T; Sasaoka, K; Watanabe, H | 1 |
Christensen, ME; Fuxa, KP | 1 |
Kimoto, M; Ogawa, T; Sasaoka, K | 1 |
Amalric, F; Dumbar, TS; Ghaffari, SH; Lapeyre, B; Olson, MO; Rao, SV | 1 |
Ahn, YS; Busch, H; Cook, RG; Lischwe, MA; Yeoman, LC | 1 |
Nissim, I; Pereira, G; Segal, S; Yudkoff, M | 1 |
Fuchs, JP; Jacob, M; Judes, C | 1 |
Brian, JE; Faraci, FM; Heistad, DD | 1 |
MacAllister, RJ; Vallance, P; Whitley, GS | 1 |
Fickling, SA; MacAllister, RJ; Vallance, P; Whitley, GS | 1 |
Aneman, A; Backman, V; Fändriks, L; Pettersson, A; Snygg, J; von Bothmer, C | 1 |
Granger, DN; Grisham, MB; Kurose, I; Wolf, R | 1 |
Kim, S; Lee, YJ; Paik, WK; Park, JO; Rawal, N; Whitaker, JN | 1 |
Aswad, DW; Johnson, BA; Najbauer, J; Young, AL | 1 |
Fickling, SA; Nussey, SS; Vallance, P; Whitley, GS; Williams, D | 1 |
Li, YJ; Xiong, Y; Yu, XJ | 1 |
Bennett, T; Gardiner, SM; Kemp, PA; Moncada, S; Palmer, RM | 1 |
Arese, M; Bosia, A; Bussolino, F; Costamagna, C; Ghigo, D; MacAllister, R; Ruva, C; Strasly, M; Tetta, C; Verzetti, G | 1 |
Barefield, D; Ram, S; White, R; Work, J | 1 |
Bode-Böger, SM; Böger, RH; Frölich, JC; Junker, W; Kienke, S | 1 |
Ellory, JC; Lane, C; Mendes Ribeiro, AC; Roberts, NB; Yaqoob, M | 1 |
Brennecke, SP; Di Iulio, JL; Gude, NM; King, RG | 1 |
D'Alecy, LG; Jin, JS | 1 |
Hoffmann, KH; MacAllister, RJ; Rambausek, MH; Ritz, E; Vallance, P; Williams, D | 1 |
Imaizumi, T; Itoh, S; Iwami, G; Kimoto, M; Kohno, K; Matsuoka, H; Okuda, S; Tamai, O; Wada, Y; Yasukawa, H | 1 |
Hecker, M; Meyer, J; Richter, N | 1 |
Alexander, K; Bode-Böger, SM; Böger, RH; Frölich, JC; Junker, W; Thiele, W | 1 |
Kim, S; Kumar, A; Merrill, BM; Paik, WK; Papov, VV; Rajpurohit, R; Schneiders, JM; Stone, KL; Szer, W; Williams, KR; Wilson, SH | 1 |
Azuma, H; Hamasaki, H; Isotani, E; Masuda, H; Obayashi, S; Sato, J; Tamaoki, S; Udagawa, T | 1 |
Backman, V; Pettersson, A; Uggla, L | 1 |
Chen, BM; Xia, LW; Zhao, RQ | 1 |
Azuma, H; Masuda, H; Niwa, K; Sato, J; Tokoro, T | 1 |
Dillon, MJ; Frend, A; Goonasekera, CD; Rees, DD; Shah, V; Woolard, P | 1 |
Anderstam, B; Bergström, J; Katzarski, K | 1 |
Bode-Böger, SM; Böger, RH | 1 |
Herlitz, H; Petersson, A; Sigström, L; Wennmalm, A; Westberg, G | 1 |
Bremer, V; Kimoto, M; Kimura, K; Ogawa, T; Omata, M; Tojo, A; Vallance, P; Welch, WJ; Wilcox, CS | 1 |
Frölich, JC; Junker, W; Tsikas, D | 1 |
Imaizumi, T; Matsuoka, H; Miyazaki, H; Okuda, S; Ueda, S; Usui, M | 1 |
Arnold, JM; Feng, Q; Fortin, AJ; Hedner, T; Kline, RL; Lu, X; Pettersson, A | 1 |
Kim, S; Lee, HW; Lim, IK; Paik, WK; Park, TJ | 1 |
Li, NS; Li, YJ; Liu, GZ; Xiong, Y; Yu, XJ | 1 |
Blaschke, TF; Bode-Böger, SM; Böger, RH; Chan, JR; Cooke, JP; Szuba, A; Tangphao, O; Tsao, PS | 1 |
Azuma, H; Hamasaki, H; Ishizaka, K; Masuda, H; Matsubara, O; Sato, J; Tamaoki, S | 1 |
Kelly, JJ; Lawson, J; Tam, SH; Whitworth, JA; Williamson, PM | 1 |
Alexander, K; Bode-Böger, SM; Böger, RH; Creutzig, A; Frölich, JC; Thiele, W | 1 |
Barnes, PJ; Cole, PJ; Dowling, RB; Newton, R; Robichaud, A; Wilson, R | 1 |
Acchiardo, SR; Cardenas, R; Chiang, TM; Kang, ES; Myers, LK; Tevlin, MT; Wang, YB | 1 |
Azuma, H; Goto, M; Masuda, H; Tamaoki, S | 1 |
Cooke, JP; Imaizumi, T; Matsuoka, H; Miyazaki, H; Okuda, S; Ueda, S; Usui, M | 2 |
Barbey, M; Bode-Böger, SM; Böger, RH; Frölich, JC; Kielstein, JT; Koch, KM; Schäffer, J | 1 |
Brand, R; Egberts, J; van den Bosch, N | 1 |
Deng, HW; Li, YJ; Lu, R; Xiong, Y | 1 |
Cartwright, JE; Holden, DP; Whitley, GS | 1 |
Aldasoro, M; Ballester, RM; Lluch, P; Lluch, S; Medina, P; Pelligrino, DA; Segarra, G; Vila, JM | 1 |
Cartwright, JE; Fickling, SA; Holden, DP; Nussey, SS; Vallance, P; Whitley, GS | 1 |
Egberts, J; Soederhuizen, P; van den Bosch, N | 1 |
Azuma, H | 1 |
Leiper, J; Vallance, P | 3 |
Fujiwara, N; Kamada, T; Katoh, T; Okumura, K; Osanai, T; Takahashi, K | 1 |
Bode-Böger, SM; Böger, RH; Cooke, JP; Imaizumi, T; Matsuoka, H; Miyazaki, H; Okuda, S; Ueda, S; Usui, M | 1 |
Al Banchaabouchi, M; D'Hooge, R; De Deyn, PP; Levillain, O; Marescau, B; Possemiers, I | 1 |
Blaschke, TF; Bode-Böger, SM; Böger, RH; Chan, JR; Cooke, JP; Tangphao, O; Tsao, PS | 1 |
Johnstone, AP; Millatt, LJ; Nussey, SS; Whitley, GS | 1 |
Arnal, JF; Bayle, C; Caussé, E; Couderc, F; Malatray, P; Salvayre, R; Siri, N; Valdiguié, P | 1 |
Bode-Böger, SM; Böger, RH; Heistad, DD; Lentz, SR; Sydow, K | 1 |
Dillon, MJ; Goonasekera, CD; Rees, DD; Shah, V | 1 |
Bode-Böger, SM; Böger, RH; Borlak, J; Lenzen, H; Schubert, B; Sydow, K; Thum, T; Tsikas, D | 1 |
Bode-Böger, SM; Böger, RH; Frölich, JC; Sandmann, J; Tsikas, D | 1 |
Kimura, K; Masuyama, Y; Nishio, I; Tsuda, K | 1 |
Berglund, L; Bryant, TA; Cannon, PJ; Chen, NT; Di Tullio, MR; Donis, JA; Fard, A; Ginsberg, HN; Homma, S; Ramasamy, R; Sciacca, R; Torres-Tamayo, M; Tuck, CH; Wu, HD | 1 |
Duan, J; Ikeda, H; Imaizumi, T; Katoh, A; Kawata, H; Murohara, T; Sasaki, K; Shintani, S; Yamamoto, N | 1 |
Bode-Böger, SM; Böger, RH; Frölich, JC; Haller, H; Kielstein, JT | 1 |
Fleck, C; Janz, A; Karge, E; Schweitzer, F; Schwertfeger, M; Stein, G | 1 |
Beck, W; Deppisch, RM; Pommer, W; Riedel, E; Schröder, M | 1 |
Vallance, P | 1 |
Bode-Böger, SM; Böger, RH; Haynes, WG; Knapp, HR; Lentz, SR | 1 |
Acchiardo, SR; Cates, TB; Kang, ES; Miles, DE; Tevlin, MT | 1 |
Baylis, C; Schmidt, RJ; Wagner, L; Xiao, S | 1 |
Cooke, JP; Oka, RK | 1 |
Fiehn, W; Gorenflo, M; Ulmer, HE; Werle, E; Zheng, C | 1 |
Aswad, DW; Bunick, GJ; Chen, D; Hanson, BL; Harp, JM; Henschen-Edman, A; Koh, SS; Mackay, DR; Schurter, BT; Stallcup, MR | 1 |
Abbs, I; Dalton, RN; Denton, M; Swaminathan, R; Turner, C; Wahbi, N | 1 |
Dreyfuss, G; Friesen, WJ; Massenet, S; Paushkin, S; Wyce, A | 1 |
Kimura, K; Masuyama, Y; Nishio, I; Shimamoto, Y; Tsuda, K | 1 |
Branscombe, TL; Clarke, S; Cook, JR; Frankel, A; Lee, JH; Pestka, S; Yang , Z | 1 |
Bengtsson, A; Ellis, J; Hagberg, H; Lilja, H; Pettersson, A; Sultan, B; Wennergren, M; Wennerholm, UB | 1 |
Cooke, JP; Eriksson, MJ; Hamsten, A; Lundman, P; Stühlinger, M; Tornvall, P | 1 |
Kimura, K; Kinoshita, Y; Masuyama, Y; Nishio, I; Tsuda, K | 1 |
Bode-Böger, SM; Böger, RH; Chowienczyk, PJ; Fisher, I; Jackson, G; McGing, E; Ritter, JM; Walker, HA | 1 |
Fliser, D; Frölich, JC; Haller, H; Kielstein, JT | 1 |
Chen, BM; Deng, HW; Li, YJ; Xiong, Y; Yuan, LW | 1 |
Lee, SC; Yoo, JH | 1 |
Abe, T; Isobe, C; Murata, T; Sato, C; Tohgi, H | 1 |
Chen, QQ; Deng, HW; Jiang, CH; Li, YJ; Qu, XP; Quarles, LD; Xiao, ZS; Yu, YH; Zhou, HH | 1 |
Abbasi, F; Asagmi, T; Cooke, JP; Lamendola, C; McLaughlin, T; Reaven, GM; Stuehlinger, M; Tsao, PS | 1 |
Dreyfuss, G; Friesen, WJ; Mann, M; Massenet, S; Paushkin, S; Pesiridis, GS; Rappsilber, J; Van Duyne, G; Wyce, A | 1 |
Balint, RF; Cooke, JP; Her, JH; Kimoto, M; Stühlinger, MC; Tsao, PS | 1 |
Bode-Böger, SM; Böger, RH; Fliser, D; Frölich, JC; Haller, H; Kielstein, JT; Ritz, E | 1 |
Aso, T; Azuma, H; Beppu, M; Goto, M; Obayashi, S | 1 |
Benedetto, FA; Böger, R; Maas, R; Mallamaci, F; Salvatore Malatino, L; Tripepi, G; Zoccali, C | 1 |
Blandon, P; Jones, KL; Levi, M; Raj, DS; Robbins, RA; Sato, E; Shah, V; Simpson, K; Vincent, B; Welbourne, TC; Zager, P | 1 |
Jaimes, EA; Leclercq, B; Raij, L | 1 |
Azuma, H; Masuda, H | 1 |
Deng, HW; Jiang, JL; Li Ns, NS; Li, YJ | 1 |
Henrion, D; Lévy, BI; Loufrani, L; Matrougui, K | 1 |
Maxwell, AJ | 1 |
Abbasi, F; Chu, JW; Cooke, JP; Lamendola, C; McLaughlin, TL; Reaven, GM; Stühlinger, MC; Tsao, PS | 1 |
Nash, DT | 1 |
Decking, UK; Fingas, CD; Janosi, RA; Laussmann, T; Schlack, W; Schlieper, GR; Schrader, J | 1 |
de Jong, S; Nijveldt, RJ; Teerlink, T; van Leeuwen, PA | 1 |
Azuma, H; Goto, M; Kihara, K; Masuda, H; Okuno, T; Tsujii, T | 2 |
Achan, V; Arrigoni, F; Leiper, JM; Tran, CT; Vallance, P; Whitley, GS | 1 |
Edebo, A; Fändriks, L; Lönroth, H; Olbe, L; Pettersson, A; von Bothmer, C | 1 |
Cooke, JP; Losordo, DW | 1 |
Abbasi, F; Asagami, T; Cooke, JP; Lamendola, C; McLaughlin, T; Reaven, GM; Stuelinger, M; Tsao, PS | 1 |
Bellanuova, I; Benedetto, FA; Böger, R; Cataliotti, A; Maas, R; Malatino, LS; Mallamaci, F; Tripepi, G; Zoccali, C | 1 |
Cardounel, AJ; Zweier, JL | 1 |
Hu, CP; Li, YJ; Liao, EY; Lu, R; Wu, XP | 1 |
Baylis, C; Couser, W; Erdely, A; Riggleman, A; Wagner, L | 1 |
Delles, C; Gekle, M; John, S; Schmieder, RE; Schneider, MP | 1 |
Martinez, AC; Mulvany, MJ; Simonsen, U; Stankevicius, E | 1 |
Adimoolam, S; Asagami, T; Cooke, JP; Ito, A; Kimoto, M; Lin, KY; Reaven, GM; Tsao, PS; Tsuji, H | 1 |
Fujii, M; Kinoshita, M; Matsumoto, T; Ohnishi, M; Takayama, T; Tsutamoto, T; Wada, A; Wang, X; Yamamoto, T | 1 |
Blomberg, M; de Jong, S; Mulder, C; Scheltens, P; Teerlink, T; van Kamp, GJ; Wahlund, LO | 1 |
Fujiwara, N; Nakamura, M; Okumura, K; Osanai, T; Osawa, H; Saitoh, M; Sasaki, S; Tomita, H; Yamabe, H | 1 |
Zoccali, C | 6 |
Egashira, K; Ito, A; Muramatsu, K; Narishige, T; Takeshita, A | 1 |
Hansson, L; Hedner, T; Himmelmann, A | 1 |
Kautzky-Willer, A; Mayer, BX; Meyer, A; Mittermayer, F; Pacini, G; Wagner, OF; Winzer, C; Wolzt, M | 1 |
Knuuti, J; Laakso, J; Laaksonen, R; Laine, H; Päivä, H; Raitakari, OT | 1 |
Chang, MS; Chen, JW; Hsu, NW; Lin, SJ; Wu, TC | 1 |
Nijveldt, RJ; Rauwerda, JA; Stehouwer, CD; Teerlink, T; Van Guldener, C; Van Leeuwen, PA | 1 |
Aagaard, E; Andreassen, AK; Aukrust, P; Frøland, SS; Gullestad, L; Haugstad, TS; Holm, T; Kjekshus, J; Simonsen, S; Ueland, T | 1 |
Hermenegildo, C; Lluch, S; Medina, P; Ortega, J; Peiró, M; Segarra, G; Vila, JM | 1 |
Chan, JC; Chan, NN | 1 |
Arakawa, N; Bode-Böger, SM; Böger, RH; Frölich, JC; Hornig, B; Schwedhelm, E; Sydow, K; Tsikas, D | 1 |
Li, NS; Li, YJ; Lu, R; Peng, J; Zhu, HQ | 1 |
Barrigón, S; Boscá, L; Calleja, J; Callejas, NA; Casado, M; Dulin, E; Garutti, I; Martín-Sanz, P; Olmedilla, L; Pérez-Peña, J; Sanz, J | 1 |
Chan, JC; Chan, NN; Chan, WB | 1 |
Maeda, T; Okamura, H; Yoshimura, T | 1 |
Arnesen, H; Eid, HM; Eritsland, J; Larsen, J; Seljeflot, I | 1 |
Isomustajärvi, M; Laakso, J; Laaksonen, R; Lehtimäki, T; Päivä, H; Ruokonen, I | 1 |
Chierchia, S; Fermo, I; Fragasso, G; Galluccio, E; Lucotti, P; Margonato, A; Monti, LD; Paroni, R; Piatti, P; Pozza, G; Setola, E | 1 |
Nijveldt, RJ; Rauwerda, JA; Siroen, MP; Teerlink, T; van Lambalgen, AA; van Leeuwen, PA | 1 |
Kuik, DJ; Nijveldt, RJ; Rauwerda, JA; Siroen, MP; Teerlink, T; Van Der Hoven, B; van Leeuwen, PA | 1 |
Nijveldt, RJ; Teerlink, T; van Leeuwen, PA | 1 |
Imaizumi, T; Kato, S; Kimoto, M; Matsuoka, H; Morimatsu, M; Okuda, S; Ueda, S | 1 |
Chen, BM; Tao, LJ; Zhang, WR | 1 |
Arrigoni, FI; Haworth, SG; Leiper, JM; Vallance, P | 1 |
de Jong, S; Neele, SJ; Netelenbos, JC; Stehouwer, CD; Teerlink, T | 1 |
Aukrust, P; Haugstad, TS; Holm, T; Holven, KB; Nenseter, MS; Ose, L | 1 |
Laakso, J; Laaksonen, R; Lehtimäki, T; Päivä, H; Pasternack, A; Rantalaiho, V; Ruokonen, I; Wirta, O | 1 |
Cooke, JP; Weis, M | 1 |
Aizawa, Y; Hori, T; Ishibashi, T; Kubota, K; Matsubara, T; Mezaki, T; Nakamura, Y; Nasuno, A; Nishio, M; Ozaki, K; Tanaka, T; Tsuchida, K; Yamazoe, M | 1 |
Bode-Böger, SM; Fliser, D; Frölich, JC; Haller, H; Kielstein, JT; Ritz, E | 1 |
McGrath, BP; Teede, HJ | 1 |
Bode-Böger, SM; Fliser, D; Haller, H; Kielstein, JT | 2 |
Bode-Böger, SM; Fliser, D; Graf, S; Haller, H; Kielstein, JT; Klein, G | 1 |
John, S; Schmieder, RE | 1 |
Frölich, JC; Hingorani, AD; Nicolaides, KH; Savvidou, MD; Tsikas, D; Vallance, P | 1 |
Hörl, WH | 1 |
Bonfigli, AR; Coppa, G; Gambini, A; Marra, M; Testa, I; Testa, R | 1 |
Abdalla, DS; Bersch, D; Bertolami, MC; Faludi, AA; Pereira, EC; Salem, M | 1 |
Achan, V; Broadhead, M; Leiper, J; MacAllister, R; Malaki, M; Vallance, P; Whitley, G | 1 |
Fujita, M; Hori, M; Kitakaze, M; Nanto, S; Node, K | 1 |
Hedner, T; Hultberg, B; Jonasson, TF; Ohlin, H | 1 |
Billecke, SS; Demady, DR; Dunbar, AY; Everett, AC; Kamada, Y; Lowe, ER; Osawa, Y | 1 |
Anderson, DE; Cooke, JP; Fleg, JL; Lakatta, EG; Scuteri, A; Stuehlinger, MC; Wright, JG | 1 |
Brook, R; Chakrabarti, A; D'Alecy, LG; Kaplan, MJ; Kehrer, C; Mukherjee, D; Pavlic, R; Pfenninger, D; Rajagopalan, S; Somers, E | 1 |
Fu, SH; Fu, YF; Xiong, Y; Zhou, HH | 1 |
Cooke, JP; Graf, EE; Kapoor, O; Malinow, MR; Oka, RK; Pachinger, O; Schmölzer, I; Stühlinger, MC; Szuba, A; Upson, BM; Wascher, TC | 1 |
Anthony, S; Arrigoni, FI; Birdsey, GM; Leiper, JM; Smith, CL; Vallance, P | 1 |
Selley, ML | 1 |
Carey, RM; Johns, RA; Leiper, JM; Li, D; Millatt, LJ; Siragy, HM; Whitley, GS | 1 |
Cartwright, JE; Holden, DP; Nussey, SS; Whitley, GS | 1 |
Kenemans, P; Post, MS; Stehouwer, CD; Teerlink, T; van der Mooren, MJ; Verhoeven, MO | 1 |
Busch, M; Fleck, C; Karge, E; Schweitzer, F; Stein, G | 1 |
Cooke, JP | 5 |
Cynober, L | 1 |
Becker, T; Frölich, JC; Klempnauer, J; Nashan, B; Rode, I; Tsikas, D | 1 |
Hanada, H; Ishizaka, H; Kamada, T; Matsunaga, T; Okumura, K; Osanai, T; Saitoh, M | 1 |
Abdulhayoglu, E; Barbato, D; Bustami, R; D'Alecy, LG; Desai, A; Handelman, GJ; Novak, JE; Rajagopalan, S; Saran, R; Warren, JS; Weitzel, W | 1 |
Böger, RH | 9 |
Matsunaga, T; Okumura, K; Osanai, T; Saitoh, M; Sasaki, S; Tomita, H | 1 |
Charng, MJ; Ding, YA; Lin, SJ; Lu, TM | 1 |
Ding, YA; Lee, WS; Lin, SJ; Lu, TM; Tai, HC | 1 |
Brattström, L; Brudin, L; Hultberg, B; Teerlink, T; Wanby, P | 1 |
Nijveldt, RJ; Prins, HA; Rauwerda, JA; Stehouwer, CD; Teerlink, T; van Guldener, C; van Lambalgen, AA; van Leeuwen, PA | 1 |
Deng, HW; Jiang, JL; Li, YJ; Lu, R; Zhang, XH; Zhu, HQ | 1 |
Magota, K; Murakami, S; Nakamura, M; Okumura, K; Osanai, T; Osawa, H; Saitoh, M; Sasaki, S; Tomita, H; Yamabe, H | 1 |
Achan, V; Adimoolam, S; Cooke, JP; Dayoub, H; Jacobi, J; Kimoto, M; Patterson, AJ; Stuehlinger, MC; Tsao, PS; Vallance, P; Wang, BY | 1 |
Bode-Böger, SM; Fliser, D; Frölich, JC; Haller, H; Hoeper, MM; Impraim, B; Kielstein, JT; Simmel, S; Tsikas, D | 1 |
Böger, RH; Cooke, JP; Vallance, P | 2 |
Isomustajärvi, M; Laakso, J; Laaksonen, R; Lakka, TA; Lehtimäki, T; Päivä, H; Ruokonen, I; Salonen, JT; Valkonen, VP | 1 |
Böger, RH; Zoccali, C | 1 |
Böger, RH; Hanefeld, C; Mügge, A | 1 |
Leiper, JM; Tran, CT; Vallance, P | 1 |
Münzel, T; Sydow, K | 1 |
Dayal, S; Lentz, SR; Rodionov, RN | 1 |
Mallamaci, F; Tripepi, G; Zoccali, C | 1 |
Cooke, JP; Gao, SZ; Kledal, TN; Lin, KY; Mocarski, ES; Panchal, SN; Valantine, HA; Weis, M | 1 |
Ritz, E | 1 |
Mittermayer, F; Namiranian, K; Pleiner, J; Schaller, G; Wolzt, M | 1 |
Böger, R; Maas, R; Malatino, L; Mallamaci, F; Tripepi, G; Zoccali, C | 1 |
Faraci, FM; Lentz, SR | 1 |
Nishio, I; Tsuda, K | 7 |
Böger, RH; Casas, JP; Díaz, LA; López-Jaramillo, P; Maas, R; Schwedhelm, E; Serrano, N | 1 |
Janatuinen, T; Knuuti, J; Laakso, J; Laaksonen, R; Lehtimäki, T; Nuutila, P; Raitakari, OT; Vesalainen, R | 1 |
Goligorsky, MS; Sawamura, T; Smirnova, IV | 1 |
Goligorsky, MS; Kajstura, M; Sawamura, T; Smirnova, IV | 1 |
Bode-Böger, SM; Dierkes, J; Luley, C; Martens-Lobenhoffer, J; Westphal, S | 1 |
Dietz, S; Faurie, F; Gross, R; Lajoix, AD; Linck, N; Mani, JC; Petit, P; Pugnière, M; Ribes, G; Roquet, F | 1 |
Kurabayashi, M; Morita, H; Nagai, R; Nakamura, T; Saito, Y | 1 |
Hirata, Y | 2 |
Boucher, JL; Brunet, A; David-Dufilho, M; Devynck, MA; Millanvoye, E; Rendu, F; Topal, G | 1 |
Azuma, H; Kihara, K; Kurosaki, E; Masuda, H; Sakai, Y; Yamauchi, Y | 1 |
Brook, JR; Brook, RD; D'Alecy, LG; Dvonch, JT; Harkema, JR; Keeler, GJ; Marsik, FJ; Morishita, M; Rajagopalan, S; Timm, EJ; Wagner, JG; Yip, FY | 1 |
Deng, HW; Jiang, DJ; Jiang, JL; Li, NS; Li, YJ; Tang, YH | 1 |
Condorelli, M; de Nigris, F; Ignarro, LJ; Liguori, A; Napoli, C; Pignalosa, O; Sica, V | 1 |
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Dehnad, A; Hajahmadi, M; Hosseini, S; Janani, L; Mofid, V; Naderi, N; Pourrajab, B; Shidfar, F; Sohouli, MH | 1 |
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Bode-Böger, SM; Bornstein, SR; Burdin, D; Chen, Y; Cordasic, N; Hilgers, K; Hofmann, A; Hohenstein, B; Hugo, CPM; Jacobi, J; Jarzebska, N; Kolouschek, A; Maas, R; Markov, AG; Martens-Lobenhoffer, J; Morawietz, H; O'Sullivan, JF; Pfluecke, C; Rodionov, RN; Rubets, E; Todorov, V; Weiss, N | 1 |
Abd El Hady, NMS; Abdallah, HM; Abdelmageed, SM; Aboelghar, HM; Garib, MI; Mahmoud, AA | 1 |
Chen, F; Chen, S; Cui, M; Dong, Q; Fang, K; Wang, Y | 1 |
Kellum, JA; Lee, Y; Singh, J | 1 |
Gao, H; Li, T; Liu, R; Wang, H; Yin, C; Zhang, Q; Zhang, T | 1 |
Belizna, C; Djokovic, A; Dopsaj, V; Marisavljevic, D; Markovic, O; Saponjski, D; Saponjski, J; Stanisavljevic, N; Stojanovich, L; Todic, B; Zdravkovic, M | 1 |
Antosiewicz, J; Calder, PC; Chroboczek, M; Fisk, HL; Jost, Z; Przewłócka, K; Tomczyk, M | 1 |
Andraweera, PH; Arstall, MA; Kosmider, L; Lassi, ZS; Tiong, P | 1 |
Lazaros, G; Oikonomou, E; Papageorgiou, N; Sagris, M; Theofilis, P; Tousoulis, D | 1 |
Dimitroulas, T; Doumas, M; Garyfallos, A; Karagiannis, A; Katsiki, N; Kitas, G; Loutradis, C; Malliari, A; Pagkopoulou, E; Soulaidopoulos, S | 1 |
Dzięgiel, P; Malicka, I; Martynowicz, H; Podhorska-Okołów, M; Szuba, A; Woźniewski, M | 1 |
Doğan, Ö; Haşimi, A; Serdar, CC; Serdar, MA | 1 |
Chen, J; Fan, S; Hong, Z; Jie, Z; Ma, Y; Mei, Z; Ni, W; Qin, A; Shen, P; Shen, S; Sun, X; Wan, S; Wang, K; Wang, Q; Wu, H; Wu, Y; Xie, Z; Xu, W; Zhang, H; Zhou, H | 1 |
Drapała, A; Samborowska, E; Szlęzak, D; Ufnal, M; Wróbel, M | 1 |
Erdogan, H; Gonulveren, G; Gultekin, G; Gultekin, M; Pasa, S; Ural, K | 1 |
Fukuo, K; Imamura, T; Otaki, N; Tanino, N; Yano, M; Yokoro, M | 1 |
Alghamdi, F; Dowsett, L; Duluc, L; Fast, W; Higgins, E; Leiper, J; Salt, IP | 1 |
He, S; Huang, C; Jiang, J; Li, G; Li, N; Li, T; Niu, B; Tong, W; Wang, S; Wu, M; Wu, T; Yan, L | 1 |
Anderson, AH; Bhat, Z; Brown, J; Brunengraber, H; Charleston, J; Chen, J; Feldman, HI; He, J; Hostetter, TH; Hsu, CY; Ix, JH; Kimmel, PL; Mehta, R; Rao, P; Sapa, H; Schelling, JR; Schrauben, SJ; Seegmiller, JC; Shafi, T; Shlipak, MG; Townsend, R; Vasan, RS; Xie, D; Zhang, X | 1 |
Bełtowski, J; Czechowska, G; Fornal, E; Góralczyk, A; Korolczuk, A; Kozub, A; Marzec-Kotarska, B; Nikolaichuk, H; Pradiuch, A; Stachniuk, A; Trzpil, A; Wójcicka, G | 1 |
Bassi, F; Böger, R; Cescutti, D; Cifù, A; Curcio, F; Fabris, M; Fapranzi, S; Hannemann, J; Ripoli, A; Sbrana, F; Sozio, E; Sponza, M; Tascini, C; Vetrugno, L | 1 |
Antosiewicz, J; Brzezińska, P; Kochanowicz, A; Kowalik, T; Mieszkowski, J; Niespodziński, B; Reczkowicz, J; Stankiewicz, B; Waldziński, T; Zolodkiewicz, K | 1 |
236 review(s) available for n,n-dimethylarginine and arginine
Article | Year |
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[Endothelial dysfunction in peripheral arterial occlusive disease: from basic research to clinical use].
Topics: Arginine; Arterial Occlusive Diseases; Arteriosclerosis; Endothelium, Vascular; Humans; Nitric Oxide; Vasodilation | 1997 |
Biological significance of endogenous methylarginines that inhibit nitric oxide synthases.
Topics: Amidohydrolases; Animals; Arginine; Cytosol; Enzyme Inhibitors; Humans; Hydrolases; Isoenzymes; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Protein-Arginine N-Methyltransferases | 1999 |
Relationship of asymmetric dimethylarginine to dialysis treatment and atherosclerotic disease.
Topics: Arginine; Arteriosclerosis; Biomarkers; Humans; In Vitro Techniques; Kidney Failure, Chronic; Nitric Oxide; Peritoneal Dialysis; Renal Dialysis; Uremia | 2001 |
Atherogenesis and the arginine hypothesis.
Topics: Arginine; Enzyme Inhibitors; Humans; Nitric Oxide | 2001 |
ADMA (asymmetric dimethylarginine): an atherosclerotic disease mediating agent in patients with renal disease?
Topics: Animals; Arginine; Arteriosclerosis; Enzyme Inhibitors; Humans; Kidney Diseases; Nitric Oxide Synthase | 2001 |
Nitric oxide synthase and hypertension.
Topics: Animals; Arginine; Endothelium, Vascular; Humans; Hypertension; Nitric Oxide Synthase | 2002 |
[Biological and pathophysiological roles of endogenous methylarginines as inhibitors of nitric oxide synthase].
Topics: Animals; Arginine; Nitric Oxide Synthase; omega-N-Methylarginine | 2002 |
Mechanisms of dysfunction of the nitric oxide pathway in vascular diseases.
Topics: Animals; Arginine; Endothelium, Vascular; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Polymorphism, Genetic; Signal Transduction; Vascular Diseases | 2002 |
Asymmetric dimethylarginine (ADMA): a potential link between endothelial dysfunction and cardiovascular diseases in insulin resistance syndrome?
Topics: Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Metabolic Syndrome | 2002 |
Cardiac allograft vasculopathy and dysregulation of the NO synthase pathway.
Topics: Animals; Arginine; Cardiovascular Agents; Coronary Artery Disease; Endothelium, Vascular; Graft Rejection; Heart Transplantation; Humans; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Postoperative Complications; Rabbits; Transplantation, Homologous; Vasodilation; Vasomotor System | 2003 |
[Cardiovascular events in chronic advanced renal insufficiency. Current concepts].
Topics: Anemia; Arginine; C-Reactive Protein; Cardiovascular Diseases; Humans; Hyperhomocysteinemia; Hyperlipidemias; Hypertension; Inflammation; Kidney Failure, Chronic; Nitric Oxide Synthase; Risk Factors; Sleep Apnea Syndromes; Smoking | 2003 |
Asymmetric dimethylarginine: a cardiovascular risk factor in renal disease?
Topics: Arginine; Cardiovascular Diseases; Humans; Kidney Diseases; Risk Factors | 2003 |
Potential mechanisms of impaired endothelial function in arterial hypertension and hypercholesterolemia.
Topics: Animals; Arginine; Biological Availability; Cyclic GMP; Endothelium, Vascular; Humans; Hypercholesterolemia; Hypertension; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Prognosis; Vasodilation | 2003 |
[Atherosclerosis and uremia: signifance of non-traditional risk factors].
Topics: Arginine; Arteriosclerosis; Homocysteine; Humans; Kidney Failure, Chronic; Oxidative Stress; Phosphates; Prognosis; Risk Factors; Uremia | 2003 |
Functional changes in the ageing kidney: is there a role for asymmetric dimethylarginine?
Topics: Adult; Aged; Aging; Arginine; Enzyme Inhibitors; Humans; Kidney; Kidney Diseases | 2003 |
[ADMA (asymmetric dimethyl arginine) and coronary artery disease].
Topics: Animals; Arginine; Coronary Disease; Humans | 2003 |
Serum concentrations of asymmetric (ADMA) and symmetric (SDMA) dimethylarginine in patients with chronic kidney diseases.
Topics: Amino Acids; Arginine; Case-Control Studies; Creatinine; Heart Diseases; Humans; Hypertension; Kidney Failure, Chronic; Kidney Transplantation; Regression Analysis; Renal Dialysis | 2003 |
A novel mechanism for pulmonary arterial hypertension?
Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Humans; Hypertension, Pulmonary; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pulmonary Artery; Rats; Vasomotor System | 2003 |
The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor.
Topics: Amidohydrolases; Arginine; Biomarkers; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide Synthase; Risk Factors | 2003 |
ADMA: a novel risk factor that explains excess cardiovascular event rate in patients with end-stage renal disease.
Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Kidney Failure, Chronic; Nitric Oxide Synthase; Risk Factors | 2003 |
Plasma concentration of asymmetric dimethylarginine and the risk of coronary heart disease: rationale and design of the multicenter CARDIAC study.
Topics: Arginine; Coronary Disease; Endothelium, Vascular; Enzyme Inhibitors; Follow-Up Studies; Humans; Nitric Oxide; Prospective Studies; Risk Factors; Vasodilation | 2003 |
The DDAH/ADMA/NOS pathway.
Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide Synthase; Vasodilation | 2003 |
ADMA and oxidative stress.
Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide Synthase; Oxidative Stress; Vasodilation | 2003 |
NO and angiogenesis.
Topics: Angiogenesis Inhibitors; Arginine; Cardiovascular Diseases; Cell Movement; Cell Survival; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide | 2003 |
Hyperhomocysteinemia, endothelial dysfunction, and cardiovascular risk: the potential role of ADMA.
Topics: Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hyperhomocysteinemia; Risk Factors | 2003 |
Novel cardiovascular risk factors in end-stage renal disease.
Topics: Arginine; Calcinosis; Cardiovascular Diseases; Humans; Hypertension; Inflammation; Kidney Failure, Chronic; Nitric Oxide Synthase; Oxidative Stress; Risk Factors | 2004 |
Atherosclerosis in dialyzed patients.
Topics: Anemia; Animals; Arginine; Arteriosclerosis; Biomarkers; Cause of Death; Comorbidity; Coronary Artery Disease; Diabetes Mellitus; Europe; Humans; Hyperlipidemias; Hypertension; Inflammation; Kidney Failure, Chronic; Mice; Mice, Knockout; Nitric Oxide; Phosphates; Renal Dialysis | 2004 |
Asymmetric dimethylarginine (ADMA) modulates endothelial function--therapeutic implications.
Topics: Animals; Arginine; Cardiovascular Diseases; Drug Therapy, Combination; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide Synthase; Up-Regulation | 2003 |
[Asymmetrical methylarginine (ADMA) as a cardiovascular risk factor: epidemiological and prospective data].
Topics: Adult; Aged; Aged, 80 and over; Animals; Arginine; Arteriosclerosis; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Cells, Cultured; Child; Coronary Disease; Diabetes Mellitus, Type 2; Disease Models, Animal; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Female; Free Radicals; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Multicenter Studies as Topic; Multivariate Analysis; Nitric Oxide Synthase; Oxidative Stress; Pre-Eclampsia; Pregnancy; Prospective Studies; Rabbits; Regression Analysis; Renal Dialysis; Risk Factors; Stroke | 2004 |
Asymmetrical dimethylarginine: the Uber marker?
Topics: Amidohydrolases; Arginine; Arteriosclerosis; Biomarkers; Blood Vessels; Endothelium, Vascular; Humans; Nitric Oxide Synthase; Risk Factors; Vascular Resistance | 2004 |
Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway.
Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Cardiovascular Physiological Phenomena; Diabetes Mellitus; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Mice; Models, Biological; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Pre-Eclampsia; Pregnancy; Protein-Arginine N-Methyltransferases; Renal Insufficiency | 2004 |
[Involvement of homocysteine in the pathogenesis of hypertension and hypertensive target-organ damage].
Topics: Arginine; Arteriosclerosis; Biopterins; Cell Division; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Hypertension; Insulin Resistance; Muscle, Smooth, Vascular; Nitric Oxide; Oxidative Stress; Risk Factors | 2004 |
[NO and hypertension].
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Arginine; Arteriosclerosis; Biopterins; C-Reactive Protein; Endothelium, Vascular; Humans; Hypertension; Mutation; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Perindopril; Reactive Oxygen Species; Vasodilation | 2004 |
The pivotal role of nitric oxide for vascular health.
Topics: Arginine; Arteriosclerosis; Cardiovascular Diseases; Disease Progression; Endothelium, Vascular; Female; Homeostasis; Humans; Male; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Predictive Value of Tests; Risk Factors; Sensitivity and Specificity; Survival Analysis | 2004 |
Asymmetric dimethylarginine (ADMA) and acute vascular events.
Topics: Acute Disease; Angina Pectoris; Arginine; Cardiovascular Diseases; Humans; Myocardial Infarction; Stroke | 2004 |
Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the "L-arginine paradox" and acts as a novel cardiovascular risk factor.
Topics: Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide Synthase; Risk Factors | 2004 |
Elimination of asymmetric dimethylarginine by the kidney and the liver: a link to the development of multiple organ failure?
Topics: Animals; Arginine; Enzyme Inhibitors; Humans; Kidney; Liver; Multiple Organ Failure; Nitric Oxide Synthase | 2004 |
[Asymmetric dimethylarginine and endothelial dysfunction].
Topics: Amidohydrolases; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Hemodynamics; Humans; Methylation; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Renin-Angiotensin System | 2004 |
Asymmetric dimethyl-L-arginine (ADMA): a possible link between homocyst(e)ine and endothelial dysfunction.
Topics: Animals; Arginine; Arteriosclerosis; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Nitric Oxide; Vascular Diseases | 2005 |
L-Arginine improves vascular function by overcoming deleterious effects of ADMA, a novel cardiovascular risk factor.
Topics: Arginine; Arteriosclerosis; Cardiovascular Diseases; Endothelium, Vascular; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III | 2005 |
Endothelial cell dysfunction: the syndrome in making.
Topics: Animals; Apoptosis; Arginine; Cardiovascular Diseases; Cellular Senescence; Endothelium, Vascular; Glycation End Products, Advanced; Humans; Hyperhomocysteinemia; Kidney Diseases; Models, Biological; Oxidative Stress; Syndrome | 2005 |
Cardiovascular tests: use & limits of biochemical markers - therapeutic measurements of ADMA involved in cardiovascular disorders.
Topics: Arginine; Biomarkers; Diagnostic Techniques, Cardiovascular; Humans | 2005 |
Clinical epidemiology of major nontraditional risk factors in peritoneal dialysis patients.
Topics: Arginine; Autonomic Nervous System Diseases; C-Reactive Protein; Cardiovascular Diseases; Humans; Hyperhomocysteinemia; Inflammation; Italy; Kidney Failure, Chronic; Nitric Oxide Synthase; Norepinephrine; Peritoneal Dialysis; Risk Factors | 2005 |
Asymmetric dimethylarginine: a cardiovascular risk factor and a uremic toxin coming of age?
Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Cardiovascular Diseases; Carotid Arteries; Carotid Stenosis; Cross-Sectional Studies; Endocrine System Diseases; Endothelium, Vascular; Haplorhini; Humans; Hypertension; Kidney Diseases; Kidney Failure, Chronic; Nitric Oxide; Rats; Rats, Inbred Dahl; Renal Dialysis; Risk Factors; Sodium Chloride, Dietary; Tunica Intima; Tunica Media; Uremia | 2005 |
Elevated levels of asymmetric dimethylarginine (ADMA) as a marker of cardiovascular disease and mortality.
Topics: Animals; Arginine; Biomarkers; Cardiovascular Diseases; Endothelial Cells; Humans; Nitric Oxide; Prognosis | 2005 |
Measurement of asymmetric dimethylarginine in plasma: methodological considerations and clinical relevance.
Topics: Animals; Arginine; Cardiovascular Diseases; Homocysteine; Humans; Risk Factors; Sensitivity and Specificity | 2005 |
Biomarkers in chronic kidney disease: utility and issues towards better understanding.
Topics: Animals; Arginine; Biomarkers; C-Reactive Protein; Chronic Disease; Disease Progression; Glomerular Filtration Rate; Homocysteine; Humans; Kidney Diseases; Kidney Failure, Chronic; Natriuretic Peptide, Brain; Troponin T | 2005 |
Nitric oxide pathway as new drug targets for refractory hypertension.
Topics: Animals; Antihypertensive Agents; Arginine; Blood Pressure; Endothelium, Vascular; Humans; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Signal Transduction; Superoxides | 2005 |
Endothelial function and its assessment.
Topics: Animals; Arginine; Atherosclerosis; C-Reactive Protein; Endothelial Cells; Endothelin-1; Endothelium, Vascular; Humans; Nitric Oxide; Stem Cells; Tissue Plasminogen Activator; Vascular Cell Adhesion Molecule-1; Vasodilation; von Willebrand Factor | 2005 |
[Molecular mechanisms of dysfunction of vascular endothelium].
Topics: Adult; Animals; Apoptosis; Arginine; Atherosclerosis; Cardiovascular Diseases; Cells, Cultured; Child; Endothelial Cells; Endothelin-1; Endothelium, Vascular; Epoprostenol; Female; GTP-Binding Proteins; Hemodynamics; Humans; Macrophages; Male; Multienzyme Complexes; Mutation; NADH, NADPH Oxidoreductases; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Pregnancy; Rats; Rats, Inbred Dahl; Reactive Oxygen Species; Risk Factors; RNA, Messenger | 2005 |
Endogenous production of nitric oxide synthase inhibitors.
Topics: Arginine; Enzyme Inhibitors; Humans; Isoenzymes; Nitric Oxide Synthase; omega-N-Methylarginine; Protein-Arginine N-Methyltransferases; Renal Insufficiency | 2005 |
ADMA: its role in vascular disease.
Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Mice; Mice, Transgenic; Models, Animal; Nitric Oxide; Nitric Oxide Synthase; Risk Factors | 2005 |
Asymmetric dimethylarginine (ADMA) and cardiovascular disease: insights from prospective clinical trials.
Topics: Arginine; Biomarkers; Cardiovascular Diseases; Clinical Trials as Topic; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide; Nitric Oxide Synthase; Prospective Studies; Randomized Controlled Trials as Topic; Risk Factors; Vasodilation | 2005 |
ADMA and hyperhomocysteinemia.
Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Homocysteine; Humans; Hyperhomocysteinemia; Nitric Oxide; Nitric Oxide Synthase Type III; Risk Factors; Superoxides; Vasodilation | 2005 |
Insulin resistance: potential role of the endogenous nitric oxide synthase inhibitor ADMA.
Topics: Animals; Arginine; Cardiovascular Diseases; Drug Evaluation, Preclinical; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metabolic Syndrome; Nitric Oxide; Nitric Oxide Synthase; Randomized Controlled Trials as Topic; Risk Factors; Vasodilation | 2005 |
DDAH gene and cardiovascular risk.
Topics: Amidohydrolases; Arginine; Cardiovascular Diseases; Humans; Hypertension; Male; Mutation; Polymorphism, Genetic; Risk Factors | 2005 |
Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA).
Topics: Amidohydrolases; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Biomarkers; Cardiovascular Diseases; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperhomocysteinemia; Nitric Oxide; Nitric Oxide Synthase; Protein-Arginine N-Methyltransferases; Renal Insufficiency | 2005 |
Spotlight on endothelial progenitor cell inhibitors: short review.
Topics: Angiotensin II; Animals; Arginine; Atherosclerosis; Bone Marrow Cells; Cell Differentiation; Cell Movement; Endothelial Cells; Humans; Lipoproteins, LDL; Nitric Oxide; Stem Cells | 2005 |
ADMA metabolism and clearance.
Topics: Amidohydrolases; Amino Acid Transport Systems, Basic; Animals; Arginine; Humans; Kidney; Kinetics; Liver; Methylation; Peptide Hydrolases; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Proteins | 2005 |
Quantification of ADMA: analytical approaches.
Topics: Arginine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Enzyme-Linked Immunosorbent Assay; Gas Chromatography-Mass Spectrometry; Humans; omega-N-Methylarginine; Reproducibility of Results | 2005 |
[The best of epidemiology and cardiovascular prevention in 2005].
Topics: Arginine; Biomarkers; Cardiovascular Diseases; Diabetes Complications; Environmental Pollutants; Humans; Metabolic Syndrome; Publishing; Risk Factors; Smoking | 2006 |
[Nephrosclerosis: Pathogenesis, pathophysiology, and therapy].
Topics: Animals; Arginine; Atherosclerosis; Embolism, Cholesterol; Endothelium, Vascular; Free Radicals; Homocysteine; Humans; Hypertension, Renal; Nephrosclerosis; Renal Artery Obstruction | 2006 |
Asymmetric dimethylarginine (ADMA): a cardiovascular and renal risk factor on the move.
Topics: Arginine; Cardiovascular Diseases; Humans; Renal Insufficiency; Risk Factors | 2006 |
[Asymmetric dimethylarginine--a novel cardiovascular risk factor].
Topics: Arginine; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus; Endothelium, Vascular; Humans; Kidney Failure, Chronic; Nitric Oxide; Nitric Oxide Synthase; Vasodilation | 2006 |
[The importance of regulation of endogenous methylarginine concentrations in clinical practice].
Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Protein-Arginine N-Methyltransferases | 2005 |
L-arginine: a new opportunity in the management of clinical derangements in dialysis patients.
Topics: Adult; Aged; Animals; Arginine; Citrulline; Diabetic Nephropathies; Endothelium, Vascular; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Renal Dialysis | 2006 |
[Nitric oxide].
Topics: Adiponectin; Aldosterone; Animals; Arginine; Blood Pressure; Cardiovascular Diseases; Endothelium, Vascular; Humans; Hypertension; Nitric Oxide; Nitric Oxide Synthase Type III; Stem Cells; Stress, Mechanical | 2006 |
HPLC analysis of ADMA and other methylated L-arginine analogs in biological fluids.
Topics: Animals; Arginine; Body Fluids; Chromatography, High Pressure Liquid; Humans; Methylation; Reference Values; Reproducibility of Results | 2007 |
Arginine, arginine analogs and nitric oxide production in chronic kidney disease.
Topics: Absorption; Amidohydrolases; Arginine; Biological Availability; Cardiovascular Diseases; Chronic Disease; Comorbidity; Enzyme Inhibitors; Humans; Kidney; Kidney Diseases; Kidney Failure, Chronic; Nitric Oxide; Nitric Oxide Synthase; Polymorphism, Genetic | 2006 |
Endogenous inhibitors of nitric oxide and preeclampsia: a review.
Topics: Amidohydrolases; Arginine; Endothelium, Vascular; Female; Humans; Nitric Oxide; Nitric Oxide Synthase; Placental Circulation; Pre-Eclampsia; Pregnancy; Uterus; Vasodilation | 2006 |
The lung in the balance: arginine, methylated arginines, and nitric oxide.
Topics: Animals; Arginine; Humans; Lung; Methylation; Models, Biological; Nitric Oxide; omega-N-Methylarginine; Protein-Arginine N-Methyltransferases | 2007 |
Protein arginine methylation: Cellular functions and methods of analysis.
Topics: Arginine; DNA Repair; F-Box Proteins; Humans; Mass Spectrometry; Methyltransferases; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Proteomics; RNA Processing, Post-Transcriptional; S-Adenosylmethionine; Signal Transduction; Transcription, Genetic | 2006 |
An overview of plasma concentrations of asymmetric dimethylarginine (ADMA) in health and disease and in clinical studies: methodological considerations.
Topics: Animals; Arginine; Chromatography, High Pressure Liquid; Clinical Laboratory Techniques; Disease; Health; Humans; Mass Spectrometry | 2007 |
Asymmetric dimethylarginine in end-stage renal disease patients: a biomarker modifiable by calcium blockade and angiotensin II antagonism?
Topics: Amlodipine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Arginine; Biomarkers; Calcium; Calcium Channel Blockers; Humans; Kidney Failure, Chronic; Risk Factors; Tetrazoles; Valine; Valsartan | 2006 |
Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH.
Topics: Amidohydrolases; Animals; Arginine; Cerebral Arteries; Cerebrovascular Circulation; Humans; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2006 |
Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: assessing the health of the endothelium.
Topics: Arginine; Biological Factors; Biomarkers; C-Reactive Protein; Cell Differentiation; Cell Proliferation; Cellular Senescence; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelial Cells; Endothelium, Vascular; Humans; Hyperglycemia; Nitric Oxide; Oxidative Stress; Stem Cells; Vasodilation; Vasodilator Agents | 2005 |
Asymmetric dimethylarginine (ADMA) a novel cardiovascular risk factor--evidence from epidemiological and prospective clinical trials.
Topics: Arginine; Biomarkers; Cardiovascular Diseases; Clinical Trials as Topic; Cross-Sectional Studies; Endothelium, Vascular; Humans; Nitric Oxide; Nitric Oxide Synthase; Prospective Studies; Risk Factors | 2006 |
[Coronary allograft vasculopathy: pathophysiological interaction between the immune system, infections and metabolic syndrome].
Topics: Animals; Arginine; Clinical Trials as Topic; Coronary Disease; Cytomegalovirus Infections; Disease Models, Animal; Endothelium, Vascular; Graft Rejection; Graft Survival; Heart Transplantation; Humans; Hypolipidemic Agents; Immunosuppression Therapy; Immunosuppressive Agents; Metabolic Syndrome; Quality of Life; Risk Assessment; Risk Factors; Rodentia; Stents; Time Factors | 2007 |
The past, presence and future of ADMA in nephrology.
Topics: Arginine; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Kidney Diseases; Kidney Function Tests; Nitric Oxide Synthase; Risk Factors | 2007 |
Asymmetric dimethylarginine (ADMA) in vascular, renal and hepatic disease and the regulatory role of L-arginine on its metabolism.
Topics: Arginine; Citrulline; Dietary Supplements; Hepatocytes; Homocysteine; Humans; Kidney Diseases; Liver Diseases; Nitric Oxide Synthase; Obesity; Risk Factors; Vascular Diseases | 2007 |
C-reactive protein and asymmetric dimethylarginine: markers or mediators in cardiovascular disorders?
Topics: Animals; Arginine; Atherosclerosis; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Humans; Inflammation; Nitric Oxide; Risk Assessment; Risk Factors | 2007 |
Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease.
Topics: Arginine; Cardiovascular Diseases; Chronic Disease; Endothelium, Vascular; Humans; Kidney Diseases; Nitric Oxide; Nitric Oxide Synthase | 2007 |
Chronic kidney disease: effects on the cardiovascular system.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarkers; Bone Resorption; Calcinosis; Calcium; Cardiovascular Diseases; Chronic Disease; Clinical Trials as Topic; Cohort Studies; Creatinine; Cystatin C; Cystatins; Diabetes Complications; Disease Progression; Dogs; Dyslipidemias; Endothelium, Vascular; Glomerular Filtration Rate; Humans; Hypertension, Renal; Inflammation Mediators; Kidney Diseases; Oxidative Stress; Phosphates; Renin-Angiotensin System; Risk Factors | 2007 |
Asymmetric dimethylarginine (ADMA)--a modulator of nociception in opiate tolerance and addiction?
Topics: Analgesics, Opioid; Arginine; Drug Tolerance; Humans; Nitric Oxide Synthase Type I; Opioid-Related Disorders; Pain | 2007 |
Arginase: a critical regulator of nitric oxide synthesis and vascular function.
Topics: Animals; Arginase; Arginine; Cardiovascular Diseases; Cell Proliferation; Collagen; Endothelium, Vascular; Homeostasis; Humans; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Urea | 2007 |
Dimethylarginine dimethylaminohydrolase: a new therapeutic target for the modulation of nitric oxide and angiogenesis.
Topics: Amidohydrolases; Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Animals; Arginine; Endothelium, Vascular; Humans; Neovascularization, Pathologic; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III | 2007 |
Nitric oxide deficiency in chronic kidney disease.
Topics: Arginine; Chronic Disease; Humans; Kidney Diseases; Nitric Oxide; Nitric Oxide Synthase | 2008 |
Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems.
Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Diabetes Mellitus; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Kidney; Kidney Diseases; Liver Diseases; Nitric Oxide; Nitric Oxide Synthase; Vasodilation | 2007 |
Emerging biomarkers for evaluating cardiovascular risk in the chronic kidney disease patient: how do new pieces fit into the uremic puzzle?
Topics: Albuminuria; Arginine; Cardiovascular Diseases; Chronic Disease; Endothelium, Vascular; Humans; Kidney Diseases; Ossification, Heterotopic; Oxidative Stress; Risk Assessment; Uremia | 2008 |
Biomarkers in acute and chronic kidney disease.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Arginine; Biomarkers; Cystatin C; Cystatins; Fatty Acid-Binding Proteins; Hepatitis A Virus Cellular Receptor 1; Humans; Interleukin-18; Lipocalin-2; Lipocalins; Membrane Glycoproteins; Predictive Value of Tests; Prognosis; Proto-Oncogene Proteins; Receptors, Virus; Renal Insufficiency, Chronic; Reproducibility of Results; Severity of Illness Index | 2008 |
Asymmetric dimethylarginine--mechanisms and targets for therapeutic management.
Topics: Angiotensin-Converting Enzyme Inhibitors; Arginine; Endothelium, Vascular; Estrogen Replacement Therapy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypoglycemic Agents; Nitric Oxide Synthase Type III | 2008 |
Determination of asymmetric dimethylarginine in biological fluids: a paradigm for a successful analytical story.
Topics: Arginine; Calibration; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Humans; Mass Spectrometry; Reference Values; Sensitivity and Specificity; Solid Phase Extraction | 2008 |
[Pathophysiology of mild hypertension: role of endothelial function].
Topics: Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arginine; Calcium Channel Blockers; Endothelium, Vascular; Humans; Hypertension; Nitric Oxide; Oxidative Stress; Randomized Controlled Trials as Topic; Severity of Illness Index | 2008 |
Cardiovascular disease in patients with diabetic nephropathy.
Topics: Anemia; Arginine; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Enzyme Inhibitors; Glycation End Products, Advanced; Homocysteine; Humans; Prognosis; Risk Factors | 2008 |
[Endothelial injury and CKD].
Topics: Animals; Arginine; Cardiovascular Diseases; Chronic Disease; Endothelium, Vascular; Humans; Kidney Diseases; Kidney Failure, Chronic; Nitric Oxide; Risk Factors | 2008 |
Asymmetric dimethylarginine (ADMA) and other endogenous nitric oxide synthase (NOS) inhibitors as an important cause of vascular insulin resistance.
Topics: Animals; Arginine; Endothelium; Enzyme Inhibitors; Humans; Insulin Resistance; Nitric Oxide; Nitric Oxide Synthase | 2008 |
[Asymmetric dimethylarginine (ADMA): A cardiovascular risk factor].
Topics: Adult; Arginine; Austria; Biomarkers; Cardiovascular Diseases; Humans; Male; Prevalence; Risk Assessment; Risk Factors | 2008 |
Cardiac biomarkers and chronic renal diseases.
Topics: Animals; Arginine; Biomarkers; C-Reactive Protein; Coronary Artery Disease; Disease Progression; Homocysteine; Humans; Kidney Failure, Chronic; Natriuretic Peptide, Brain; Troponin | 2008 |
[Novelties in the field of progression factors in chronic kidney disease].
Topics: Adult; Amidohydrolases; Animals; Arginine; Carbon; Cardiovascular Diseases; Chronic Disease; Clinical Trials as Topic; Disease Progression; Female; Genetic Therapy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infant, Low Birth Weight; Infant, Newborn; Kidney Diseases; Male; Oxides; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Uremia; Uric Acid | 2008 |
L-arginine analogs--inactive markers or active agents in atherogenesis?
Topics: Arginine; Atherosclerosis; Biomarkers; Coronary Disease; Endothelium, Vascular; Humans; Inflammation; Nitric Oxide; Oxidative Stress | 2008 |
Asymmetric dimethylarginine: a novel marker of risk and a potential target for therapy in chronic kidney disease.
Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Chronic Disease; Disease Progression; Genetic Therapy; Glomerular Filtration Rate; Growth Hormone; Humans; Kidney Diseases; Obesity; Risk Factors; Severity of Illness Index; Treatment Outcome | 2008 |
Roles of oxidants, nitric oxide, and asymmetric dimethylarginine in endothelial function.
Topics: Animals; Arginine; Atherosclerosis; Endothelium, Vascular; Humans; Models, Biological; Nitric Oxide; Oxidants; Reactive Oxygen Species; Risk Factors | 2008 |
ADMA, cardiovascular disease and diabetes.
Topics: Arginine; Cardiovascular Diseases; Diabetes Mellitus; Humans; Models, Biological | 2008 |
Role of asymmetric dimethylarginine (ADMA) in diabetic vascular complications.
Topics: Amidohydrolases; Animals; Arginine; Diabetic Angiopathies; Humans; Nitric Oxide Synthase; Risk Factors | 2008 |
From arginine methylation to ADMA: a novel mechanism with therapeutic potential in chronic lung diseases.
Topics: Arginine; Biomarkers; Chronic Disease; Humans; Lung Diseases; Methylation; Protein Processing, Post-Translational | 2009 |
Dimethylarginine dimethylaminohydrolase regulation: a novel therapeutic target in cardiovascular disease.
Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Agents; Cardiovascular Diseases; Disease Progression; Drug Delivery Systems; Gene Expression Regulation, Enzymologic; Humans; Nitric Oxide | 2009 |
Asymmetric dimethylarginine (ADMA): an endogenous inhibitor of nitric oxide synthase and a novel cardiovascular risk molecule.
Topics: Animals; Arginine; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Kidney; Nitric Oxide Synthase; Risk Factors | 2009 |
[Biology of arterial ageing and arteriosclerosis].
Topics: Adult; Aged; Aging; Arginine; Arteriosclerosis; Atherosclerosis; Calcinosis; Diagnostic Techniques, Cardiovascular; Endothelium, Vascular; Extracellular Matrix; Female; Humans; Hypertension; Lipoproteins; Male; Middle Aged; Monocytes; Osteoblasts; Tunica Media; Vascular Resistance | 2009 |
Asymmetric dimethylarginine (ADMA) and endothelial dysfunction: implications for atherogenesis.
Topics: Animals; Arginine; Atherosclerosis; Biomarkers; Endothelium, Vascular; Humans; Nitric Oxide; Renal Insufficiency, Chronic | 2009 |
Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality--an update on patient populations with a wide range of cardiovascular risk.
Topics: Animals; Arginine; Biomarkers; Cardiovascular Diseases; Clinical Trials as Topic; Humans; Prospective Studies; Risk Factors | 2009 |
ADMA and the role of the genes: lessons from genetically modified animals and human gene polymorphisms.
Topics: Animals; Animals, Genetically Modified; Arginine; Disease Models, Animal; Humans; Polymorphism, Genetic | 2009 |
Cellular ADMA: regulation and action.
Topics: Animals; Arginine; Cardiovascular Diseases; Endothelial Cells; Humans; Nitric Oxide Synthase; Signal Transduction | 2009 |
Role of the PRMT-DDAH-ADMA axis in the regulation of endothelial nitric oxide production.
Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Cardiovascular Diseases; Endothelium, Vascular; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Protein-Arginine N-Methyltransferases | 2009 |
The emerging role of symmetric dimethylarginine in vascular disease.
Topics: Arginine; Cardiovascular Diseases; Homeostasis; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Renal Insufficiency | 2009 |
The role of nitric oxide synthase inhibition by asymmetric dimethylarginine in the pathophysiology of preeclampsia.
Topics: Arginine; Biomarkers; Endothelium, Vascular; Female; Humans; Nitric Oxide Synthase; Pre-Eclampsia; Pregnancy | 2010 |
The DDAH/ADMA pathway in the control of endothelial cell migration and angiogenesis.
Topics: Amidohydrolases; Animals; Apoptosis; Arginine; Cell Movement; Cell Proliferation; Endothelial Cells; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Humans; Neovascularization, Physiologic; Nitric Oxide Synthase; rho GTP-Binding Proteins; Signal Transduction; Stem Cells | 2009 |
Stroke biomarkers: progress and challenges for diagnosis, prognosis, differentiation, and treatment.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Arginine; Biomarkers; Diffusion Magnetic Resonance Imaging; Glial Fibrillary Acidic Protein; Humans; Matrix Metalloproteinase 9; Nerve Growth Factors; Prognosis; Receptors, N-Methyl-D-Aspartate; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Stroke; Tomography, X-Ray Computed | 2010 |
The biochemistry, measurement and current clinical significance of asymmetric dimethylarginine.
Topics: Amidohydrolases; Animals; Arginine; Biochemistry; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Metabolic Clearance Rate; Models, Biological; Nitric Oxide Synthase; Oxidative Stress; Prognosis | 2010 |
[Homocysteine and asymmetric dimethylarginine (ADMA) in epilepsy].
Topics: Anticonvulsants; Arginine; Carbamazepine; Epilepsy; Homocysteine; Humans; Nitric Oxide; Nitric Oxide Synthase; Valproic Acid | 2009 |
Nitric oxide and oxidative stress in vascular disease.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Arginine; Aryldialkylphosphatase; Biopterins; Calcium; Cardiovascular Diseases; Catalase; Electron Transport; Glutathione Peroxidase; Heme Oxygenase (Decyclizing); Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mitochondria; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Protein Multimerization; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Risk Factors; Superoxide Dismutase; Superoxides; Thioredoxins; Vascular Diseases; Xanthine Oxidase | 2010 |
Asymmetric dimethylarginine as a mediator of vascular dysfunction and a marker of cardiovascular disease and mortality: an intriguing interaction with diabetes mellitus.
Topics: Arginine; Diabetic Angiopathies; Endothelium, Vascular; Humans | 2010 |
Emerging interface between metabolic syndrome and asthma.
Topics: Animals; Arginase; Arginine; Asthma; Humans; Hyperinsulinism; Inflammation; Insulin; Insulin Resistance; Metabolic Syndrome; Mice; Mitochondria; Nitric Oxide Synthase Type III; Somatomedins; Th2 Cells | 2011 |
Usefulness of cardiovascular biomarkers and cardiac imaging in systemic rheumatic diseases.
Topics: Arginine; Atherosclerosis; Biomarkers; C-Reactive Protein; Diagnostic Imaging; Early Diagnosis; High-Throughput Screening Assays; Humans; Rheumatic Diseases; Risk Factors; Serum Amyloid P-Component | 2010 |
Effect of selected drugs on plasma asymmetric dimethylarginine (ADMA) levels.
Topics: Adrenergic beta-Antagonists; Amidohydrolases; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Arginine; Aspirin; Estrogens; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Receptors, Cytoplasmic and Nuclear; Vitamin A; Vitamin B Complex; Vitamins | 2010 |
Post-challenge hyperglycaemia, nitric oxide production and endothelial dysfunction: the putative role of asymmetric dimethylarginine (ADMA).
Topics: Animals; Arginine; Diabetes Mellitus, Type 2; Endothelium, Vascular; Glucose; Glucose Tolerance Test; Heart Diseases; Humans; Hyperglycemia; Metabolic Diseases; Nitric Oxide; Oxidative Stress | 2011 |
Pharmacological interventions on asymmetric dimethylarginine, a clinical marker of vascular disease.
Topics: Adrenergic Antagonists; Angiotensins; Arginine; Diabetes Complications; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperhomocysteinemia; Hypertension; Kidney Diseases; Microcirculation; Nitric Oxide Synthase Type III; Peroxisome Proliferator-Activated Receptors; Receptors, Cytoplasmic and Nuclear; Vascular Diseases | 2011 |
L-arginine, NO and asymmetrical dimethylarginine in hypertension and type 2 diabetes.
Topics: Animals; Antihypertensive Agents; Arginine; Diabetes Mellitus, Type 2; Endothelium, Vascular; Humans; Hypertension; Insulin Resistance; Nitric Oxide; Nitric Oxide Synthase Type III; Prognosis | 2011 |
The biology and therapeutic potential of the DDAH/ADMA pathway.
Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Molecular Targeted Therapy; Nitric Oxide; Nitric Oxide Synthase | 2010 |
Novel endothelial biomarkers: implications for periodontal disease and CVD.
Topics: Animals; Arginine; Biomarkers; Cardiovascular Diseases; Cell-Derived Microparticles; Endothelial Cells; Endothelium, Vascular; Gingivitis; Humans; Nitric Oxide Synthase; Periodontitis; Stem Cells | 2011 |
Asymmetric dimethylarginine: clinical applications in pediatric medicine.
Topics: Arginine; Biomarkers; Cardiovascular Diseases; Child, Preschool; Endothelium, Vascular; Enzyme Inhibitors; Humans; Infant; Nitric Oxide Synthase; Pediatrics; Reference Values; Risk Factors | 2011 |
The role of asymmetric and symmetric dimethylarginines in renal disease.
Topics: Arginine; Humans; Kidney; Renal Insufficiency, Chronic; Risk Factors | 2011 |
The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis.
Topics: Amidohydrolases; Animals; Arginine; Cytoplasm; Drug Delivery Systems; Humans; Methylation; Nitric Oxide; Nitric Oxide Synthase; Protein Isoforms; Protein Processing, Post-Translational | 2011 |
Oxidative stress and endothelial dysfunction in hypertension.
Topics: Animals; Arginine; Endothelium, Vascular; Humans; Hypertension; NADPH Oxidases; Nitric Oxide Synthase Type III; Oxidative Stress; Prognosis; Reactive Oxygen Species; Xanthine Oxidase | 2011 |
[Analysis of transporter function and development to clinical application].
Topics: Aconitic Acid; Animals; Arginine; Guanidines; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperuricemia; Kidney; Organic Anion Transporters; Organic Cation Transport Proteins; Rats; Renal Insufficiency; Succinates | 2011 |
Asymmetric dimethylarginine: a novel biomarker of gastric mucosal injury?
Topics: Animals; Arginine; Biomarkers; Gastric Mucosa; Helicobacter pylori; Humans; Nicotine; Nitric Oxide | 2011 |
Nitric oxide (NO) and asymmetric dimethylarginine (ADMA): their pathophysiological role and involvement in intracerebral hemorrhage.
Topics: Animals; Arginine; Cerebral Hemorrhage; Humans; Nitric Oxide; Nitric Oxide Synthase | 2011 |
The biochemistry of asthma.
Topics: Aldehyde Oxidoreductases; Animals; Arginase; Arginine; Asthma; Humans; Hydrogen-Ion Concentration; Nitrites | 2011 |
Nitric oxide synthase derangements and hypertension in kidney disease.
Topics: Amidohydrolases; Animals; Arginine; Chronic Disease; Disease Progression; Humans; Hypertension; Kidney; Kidney Diseases; Nitric Oxide; Nitric Oxide Synthase | 2012 |
Peripheral hemorheological and vascular correlates of coronary blood flow.
Topics: Arginine; Blood Flow Velocity; Chest Pain; Coronary Circulation; Diagnosis, Differential; Endothelium, Vascular; Female; Hemorheology; Humans; Hyperhomocysteinemia; Inflammation; Male; Microvessels; Myocardial Ischemia; Nitric Oxide; Platelet Activation; Syndrome; Vascular Resistance; Vasodilator Agents | 2011 |
Asymmetric dimethylarginine and reactive oxygen species: unwelcome twin visitors to the cardiovascular and kidney disease tables.
Topics: Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Humans; Kidney Diseases; Rats; Reactive Oxygen Species; Risk Factors | 2012 |
Cardiovascular involvement in psoriatic arthritis.
Topics: Antirheumatic Agents; Arginine; Arthritis, Psoriatic; Coronary Circulation; Coronary Disease; Cytokines; Heart Diseases; Humans; Inflammation; Microcirculation; Risk Factors; Tumor Necrosis Factor-alpha | 2011 |
Association of circulating levels of asymmetric dimethylarginine (ADMA) with carotid intima-media thickness: evidence from 6168 participants.
Topics: Adult; Aged; Arginine; Carotid Intima-Media Thickness; Epidemiologic Studies; Female; Humans; Kidney Function Tests; Male; Middle Aged; Nitric Oxide Synthase; Renal Insufficiency, Chronic; Statistics as Topic | 2013 |
Endogenous nitric oxide synthase inhibitors in the biology of disease: markers, mediators, and regulators?
Topics: Amidohydrolases; Animals; Arginine; Binding Sites; Binding, Competitive; Biomarkers; Cardiovascular Agents; Cardiovascular Diseases; Catalytic Domain; Enzyme Inhibitors; Humans; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine | 2012 |
[Methylarginies-induced endothelial dysfunction in chronic kidney disease].
Topics: Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Renal Insufficiency, Chronic; Risk Factors | 2012 |
New directions in cardiovascular risk assessment: the role of secondary risk stratification markers.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Adrenomedullin; Ankle Brachial Index; Arginine; Biomarkers; Blood Flow Velocity; C-Reactive Protein; Cardiovascular Diseases; Carotid Intima-Media Thickness; Early Diagnosis; Humans; Lipoprotein(a); Natriuretic Peptide, Brain; Peptide Fragments; Protein Precursors; Risk Assessment; Troponin; Vascular Calcification; Vasodilation | 2012 |
Biomarkers in hemodialysis patients.
Topics: Animals; Arginine; Biomarkers; Cardiovascular Physiological Phenomena; Cell Adhesion Molecules; Humans; Inflammation; Kidney Failure, Chronic; Natriuretic Peptide, Brain; Renal Dialysis; Troponin | 2012 |
Biomarkers in pre-eclampsia: a novel approach to early detection of the disease.
Topics: Antigens, CD; Arginine; Biomarkers; Endoglin; Female; Galectins; Homocysteine; Humans; Leptin; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; Pregnancy Trimester, First; Pregnancy-Associated Plasma Protein-A; Receptors, Cell Surface; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2012 |
The impact of asymmetric dimethylarginine (ADAMA), the endogenous nitric oxide (NO) synthase inhibitor, to the pathogenesis of gastric mucosal damage.
Topics: Animals; Apoptosis; Arginine; Gastric Mucosa; Gastrointestinal Tract; Helicobacter Infections; Helicobacter pylori; Humans; Inflammation; Nitric Oxide; Nitric Oxide Synthase; Rats; Risk Factors | 2013 |
Cardiovascular risk in autoimmune disorders: role of asymmetric dimethylarginine.
Topics: Animals; Arginine; Autoimmune Diseases; Cardiovascular Diseases; Humans; Risk | 2012 |
Asymmetric dimethylarginine: a possible link between vascular disease and dementia.
Topics: Arginine; Brain; Dementia; Endothelium; Enzyme Inhibitors; Humans; Neuroprotective Agents; Nitric Oxide; Oxidative Stress; Risk Factors; Vascular Diseases | 2013 |
The role of dimethylarginine dimethylaminohydrolase (DDAH) in pulmonary fibrosis.
Topics: Amidohydrolases; Animals; Arginine; Enzyme Inhibitors; Humans; Idiopathic Pulmonary Fibrosis; Lung; Nitric Oxide; Nitric Oxide Synthase Type II; Signal Transduction | 2013 |
Asymmetric dimethylarginine, endothelial dysfunction and renal disease.
Topics: Adult; Amidohydrolases; Arginine; Biomarkers; Cardiovascular Diseases; Child; Disease Progression; Endothelial Cells; Endothelium, Vascular; Humans; Kidney; Kidney Diseases; Kidney Transplantation; Nitric Oxide; Oxidative Stress; Risk Factors | 2012 |
Asymmetric dimethylarginine as a surrogate marker of endothelial dysfunction and cardiovascular risk in patients with systemic rheumatic diseases.
Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Nitric Oxide; Nitric Oxide Synthase; Rheumatic Diseases; Risk Factors | 2012 |
Roles of nitric oxide and asymmetric dimethylarginine in pregnancy and fetal programming.
Topics: Animals; Arginine; Female; Fetal Development; Humans; Metabolic Networks and Pathways; Nitric Oxide; Placenta; Placental Insufficiency; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects | 2012 |
Beta blockers, nitric oxide, and cardiovascular disease.
Topics: Adrenergic beta-Antagonists; Animals; Antioxidants; Arginine; Cardiovascular Diseases; Humans; Nitric Oxide; Vasodilation | 2013 |
Clinical and research markers of oxidative stress in chronic kidney disease.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Advanced Oxidation Protein Products; Arginine; Biomarkers; Clinical Trials as Topic; Deoxyguanosine; F2-Isoprostanes; Glutathione; Humans; Kidney; Lipid Peroxidation; Lipid Peroxides; Malondialdehyde; Oxidative Stress; Protein Carbonylation; Renal Insufficiency, Chronic | 2013 |
Asymmetric dimethyarginine as marker and mediator in ischemic stroke.
Topics: Animals; Arginine; Biomarkers; Brain Ischemia; Cerebrovascular Circulation; Enzyme Inhibitors; Humans; Methylation; Nitric Oxide Synthase; Oxidative Stress; Protein Processing, Post-Translational; Stroke | 2012 |
Asymmetric Dimethylarginine (ADMA): a promising biomarker for cardiovascular disease?
Topics: Aging; Amidohydrolases; Arginine; Biomarkers; Cardiovascular Diseases; Cerebrovascular Disorders; Chromatography, High Pressure Liquid; Diabetes Complications; Enzyme-Linked Immunosorbent Assay; Humans; Hypertension; Mass Spectrometry; Nitric Oxide; Oxidative Stress; Reference Values; Risk Factors; Smoking | 2013 |
A novel metabolic balance model for describing the metabolic disruption of and interactions between cardiovascular-related markers during acute myocardial infarction.
Topics: Acute Disease; Adenosine Triphosphate; Amidohydrolases; Animals; Arginine; Biomarkers; Cardiovascular System; Kidney; Male; Myocardial Infarction; Rats; Rats, Sprague-Dawley | 2013 |
Role of asymmetric dimethylarginine in cardiorenal syndrome.
Topics: Animals; Arginine; Cardio-Renal Syndrome; Cardiovascular Agents; Drug Delivery Systems; Humans; Nitric Oxide Synthase | 2014 |
Asymmetric dimethylarginine and critical illness.
Topics: Amidohydrolases; Arginine; Critical Illness; Enzyme Inhibitors; Heart Failure; Humans; Intensive Care Units; Nitric Oxide; Nitric Oxide Synthase; Risk Factors | 2014 |
Is asymmetric dimethylarginine associated with being born small and large for gestational age?
Topics: Arginine; Biomarkers; Birth Weight; Cardiovascular Diseases; Female; Gestational Age; Humans; Metabolic Diseases; Pregnancy | 2014 |
Increased circulatory asymmetric dimethylarginine and multiple organ failure: bile duct ligation in rat as a model.
Topics: Animals; Arginine; Bile Ducts; Disease Models, Animal; Fibrosis; Ligation; Liver; Liver Cirrhosis; Multiple Organ Failure; Rats | 2014 |
The endothelial ADMA/NO pathway in hypoxia-related chronic respiratory diseases.
Topics: Amidohydrolases; Animals; Arginine; Chronic Disease; Humans; Hypoxia; Nitric Oxide; Respiratory Tract Diseases | 2014 |
Dimethylarginines ADMA and SDMA: the real water-soluble small toxins?
Topics: Arginine; Biomarkers; Cardiovascular Diseases; Humans; Kidney Diseases; Water | 2014 |
Restoration of asymmetric dimethylarginine-nitric oxide balance to prevent the development of hypertension.
Topics: Animals; Arginine; Humans; Hypertension; Nitric Oxide | 2014 |
Endothelial (dys)function in lone atrial fibrillation.
Topics: Arginine; Atrial Fibrillation; Biomarkers; E-Selectin; Endocardium; Endothelium, Vascular; Humans; Predictive Value of Tests; Prognosis; Risk Factors; Thrombomodulin; von Willebrand Factor | 2015 |
The association between systemic sclerosis, arginine and asymmetric dimethylarginine.
Topics: Animals; Arginine; Case-Control Studies; Humans; Nitric Oxide; Scleroderma, Systemic | 2015 |
Arginine metabolism in asthma.
Topics: Animals; Anti-Asthmatic Agents; Arginine; Asthma; Bronchial Hyperreactivity; Humans; Molecular Targeted Therapy; Nitric Oxide Synthase | 2014 |
Recovery from acute kidney injury: the role of biomarkers.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Apoptosis Regulatory Proteins; Arginine; Biomarkers; Coronary Artery Bypass; Creatinine; Critical Care; Cytokine TWEAK; Diagnosis, Differential; Diuresis; Glomerular Filtration Rate; Graft Rejection; Hepatitis A Virus Cellular Receptor 1; Humans; Interleukin-18; Kidney; Kidney Transplantation; Lipocalin-2; Lipocalins; Membrane Glycoproteins; Membrane Proteins; Peptides; Postoperative Complications; Prognosis; Proto-Oncogene Proteins; Receptors, Virus; Recovery of Function; Renal Replacement Therapy; Reperfusion Injury; Severity of Illness Index; Trefoil Factor-3; Tumor Necrosis Factors | 2014 |
Asymmetric Dimethylarginine (ADMA) in cardiovascular and renal disease.
Topics: Arginine; Cardiovascular Diseases; Humans; Kidney Diseases; Kidney Transplantation; Nitric Oxide; Nitric Oxide Synthase; Proteinuria | 2015 |
Nutritional factors in the prevention and management of coronary artery disease and heart failure.
Topics: Alprostadil; Anti-Inflammatory Agents; Arginine; CD59 Antigens; Coronary Artery Disease; Diabetes Mellitus, Type 2; Epoprostenol; Fatty Acids, Essential; Fatty Acids, Unsaturated; Female; Folic Acid; Heart Failure; Humans; Hypertension; Lipoxins; Magnesium; Male; Middle Aged; Nitric Oxide; Nutritional Status; Serum Albumin; Vasodilation; Vitamin B 12; Vitamin B 6 | 2015 |
Liver plays a central role in asymmetric dimethylarginine-mediated organ injury.
Topics: Animals; Arginine; Biomarkers; Critical Illness; Humans; Liver; Liver Diseases; Multiple Organ Failure; Prognosis; Risk Factors; Signal Transduction; Up-Regulation | 2015 |
Levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, and risk of coronary artery disease: A meta-analysis based on 4713 participants.
Topics: Adult; Aged; Arginine; Biomarkers; Case-Control Studies; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Prognosis; Risk Assessment; Risk Factors; Up-Regulation | 2016 |
A systematic review and meta-analysis of the effect of statins on plasma asymmetric dimethylarginine concentrations.
Topics: Arginine; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Publication Bias; Randomized Controlled Trials as Topic | 2015 |
Asymmetric dimethylarginine and cardiovascular risk: systematic review and meta-analysis of 22 prospective studies.
Topics: Arginine; Cardiovascular Diseases; Humans; Odds Ratio; Prospective Studies; Stroke | 2015 |
Sodium Intake as a Modulator of Kidney Function.
Topics: Angiotensin I; Arginine; Blood Pressure; Homeostasis; Humans; Kidney; Peptide Fragments; Sodium, Dietary | 2015 |
Asymmetric Dimethylarginine: Clinical Significance and Novel Therapeutic Approaches.
Topics: Alzheimer Disease; Animals; Arginine; Cardiovascular Diseases; Diabetes Mellitus; Female; Humans; Hypercholesterolemia; Neoplasms; Pre-Eclampsia; Pregnancy; Renal Insufficiency, Chronic | 2015 |
Homoarginine in the shadow of asymmetric dimethylarginine: from nitric oxide to cardiovascular disease.
Topics: Amidinotransferases; Animals; Arginine; Atherosclerosis; Endothelium, Vascular; Homoarginine; Humans; Nitric Oxide; Nitric Oxide Synthase Type III | 2015 |
Asymmetric dimethylarginine as a mediator of vascular dysfunction in cirrhosis.
Topics: Amidohydrolases; Animals; Arginine; Hemodynamics; Humans; Hypertension, Portal; Liver; Liver Cirrhosis; Nitric Oxide; Nitric Oxide Synthase Type III; Portal Vein | 2015 |
Diet in children with phenylketonuria and risk of cardiovascular disease: A narrative overview.
Topics: Adiponectin; Arginine; Blood Pressure; Cardiovascular Diseases; Child; Cholesterol, HDL; Cholesterol, LDL; Diet; Homocysteine; Humans; Oxidative Stress; Pediatric Obesity; Phenylalanine; Phenylketonurias; Risk Factors | 2016 |
Endothelial Dysfunction in Renal Failure: Current Update.
Topics: Arginine; Endothelium, Vascular; Humans; Nitric Oxide; Oxidative Stress; Renal Insufficiency; Uremia; Vascular Cell Adhesion Molecule-1; Vitamin D Deficiency | 2016 |
Effect of asymmetric dimethylarginine (ADMA) on heart failure development.
Topics: Amidohydrolases; Animals; Arginine; Heart Failure; Humans; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Peroxynitrous Acid; Signal Transduction; Superoxides | 2016 |
Potential Signaling Pathways Involved in the Clinical Application of Oxymatrine.
Topics: Alkaloids; Arginine; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-bcl-2; Quinolizines; Signal Transduction; Sophora; STAT Transcription Factors; Toll-Like Receptors; Transforming Growth Factor beta | 2016 |
When Is It Appropriate to Use Arginine in Critical Illness?
Topics: Arginine; Critical Care; Critical Illness; Dietary Supplements; Humans | 2016 |
The cytoskeleton as a novel target for treatment of renal fibrosis.
Topics: Actins; Animals; Arginine; Cytoskeleton; Disease Progression; Epithelial Cells; Fibrosis; Humans; Kidney Failure, Chronic; Podocytes; Renal Insufficiency, Chronic; rho-Associated Kinases | 2016 |
Circulating Biomarkers of Diabetic Retinopathy: An Overview Based on Physiopathology.
Topics: Adrenomedullin; Arginine; Autoantibodies; Basement Membrane; Biomarkers; C-Reactive Protein; Collagen Type IV; Diabetic Retinopathy; E-Selectin; Endothelial Progenitor Cells; Extracellular Matrix; Glycation End Products, Advanced; Homocysteine; Humans; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-6; Laminin; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; MicroRNAs; Retinol-Binding Proteins, Plasma; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2016 |
Nitric Oxide's Involvement in the Spectrum of Psychotic Disorders.
Topics: Antipsychotic Agents; Arginine; Brain; Clinical Trials as Topic; Humans; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase 5 Inhibitors; Psychotic Disorders; Schizophrenia; Sildenafil Citrate | 2016 |
Role of Asymmetrical Dimethylarginine in Diabetic Microvascular Complications.
Topics: Animals; Arginine; Biomarkers; Diabetes Mellitus; Diabetic Angiopathies; Enzyme Inhibitors; Humans; Nitric Oxide Synthase | 2016 |
Asymmetric Dimethylarginine and Hepatic Encephalopathy: Cause, Effect or Association?
Topics: Animals; Arginine; Brain; Cognition Disorders; Endothelium, Vascular; Hepatic Encephalopathy; Humans; Inflammation; Nitric Oxide Synthase; Nitrosation; Oxidative Stress | 2017 |
Targeting on Asymmetric Dimethylarginine-Related Nitric Oxide-Reactive Oxygen Species Imbalance to Reprogram the Development of Hypertension.
Topics: Animals; Arginine; Humans; Hypertension; Kidney; Nitric Oxide; Reactive Oxygen Species | 2016 |
Novel Pathophysiological Mechanisms in Hypertension.
Topics: Animals; Antihypertensive Agents; Arginine; Biomarkers; Blood Pressure; Cytokines; Drug Resistance; Humans; Hypertension; Immunity, Innate; Inflammation Mediators; Renin-Angiotensin System; Signal Transduction | 2017 |
Pathophysiological Role of Adiponectin, Leptin and Asymmetric Dimethylarginine in the Process of Atherosclerosis.
Topics: Adiponectin; Arginine; Atherosclerosis; C-Reactive Protein; E-Selectin; Endothelin-1; Humans; Intercellular Adhesion Molecule-1; Interleukin-8; Leptin; Nitric Oxide; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2016 |
Oxidative Stress and Cardiovascular Aging: Interaction Between NRF-2 and ADMA.
Topics: Aging; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction | 2017 |
Toxic Dimethylarginines: Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA).
Topics: Animals; Arginine; Humans; Toxins, Biological | 2017 |
Interplay between Oxidative Stress and Nutrient Sensing Signaling in the Developmental Origins of Cardiovascular Disease.
Topics: Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Energy Metabolism; Humans; Nitric Oxide; Nutritional Physiological Phenomena; Oxidative Stress; Reactive Oxygen Species; Signal Transduction | 2017 |
The issue of plasma asymmetric dimethylarginine reference range - A systematic review and meta-analysis.
Topics: Arginine; Chromatography, High Pressure Liquid; Confidence Intervals; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Reference Values | 2017 |
An Expanding Role of Biomarkers in Pulmonary Arterial Hypertension.
Topics: Arginine; Biomarkers; Endothelins; Humans; Hypertension, Pulmonary; Prognosis; Sensitivity and Specificity; Severity of Illness Index; von Willebrand Factor | 2017 |
Polycystic ovarian syndrome-associated cardiovascular complications: An overview of the association between the biochemical markers and potential strategies for their prevention and elimination.
Topics: Arginine; Biomarkers; Cardiovascular Diseases; Female; Glycation End Products, Advanced; Homocysteine; Humans; Oxidative Stress; Polycystic Ovary Syndrome; Receptor for Advanced Glycation End Products; von Willebrand Factor | 2017 |
Using Chemistry to Target Neuroblastoma.
Topics: Animals; Arginine; Humans; Neural Crest; Neuroblastoma; Oncogene Proteins; Reactive Oxygen Species; Signal Transduction | 2017 |
Prognostic efficacy of circulating asymmetric dimethylarginine in patients with peripheral arterial disease: A meta-analysis of prospective cohort studies.
Topics: Arginine; Atherosclerosis; Biomarkers; Female; Humans; Male; Middle Aged; Peripheral Arterial Disease; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Factors | 2018 |
AGXT2: An unnegligible aminotransferase in cardiovascular and urinary systems.
Topics: Animals; Arginine; Cardiovascular Diseases; Cardiovascular System; Humans; Kidney Diseases; Transaminases | 2017 |
Nitric oxide bioavailability dysfunction involves in atherosclerosis.
Topics: Animals; Arginine; Atherosclerosis; Biological Availability; Cardiovascular Diseases; Endothelium, Vascular; Humans; Nitric Oxide; Obesity; Oxidative Stress; Smoking; Vasodilation | 2018 |
Association of Circulating Levels of ADMA with Carotid Intima-Media Thickness in Patients with CKD: a Systematic Review and Meta-Analysis.
Topics: Arginine; Atherosclerosis; Cardiovascular Diseases; Carotid Intima-Media Thickness; Humans; Renal Insufficiency, Chronic | 2018 |
Asymmetric Dimethyl Arginine as a Biomarker of Atherosclerosis in Rheumatoid Arthritis.
Topics: Animals; Arginine; Arthritis, Rheumatoid; Atherosclerosis; Biomarkers; Humans | 2018 |
Asymmetric dimethylarginine (ADMA) as an important risk factor for the increased cardiovascular diseases and heart failure in chronic kidney disease.
Topics: Amidohydrolases; Animals; Arginine; Endothelium, Vascular; Heart Failure; Humans; Nitric Oxide Synthase; omega-N-Methylarginine; Renal Insufficiency, Chronic; Risk Factors; Signal Transduction | 2018 |
Systemic concentrations of asymmetric dimethylarginine (ADMA) in chronic obstructive pulmonary disease (COPD): state of the art.
Topics: Animals; Arginine; Humans; Nitric Oxide Synthase; Oxidative Stress; Pulmonary Disease, Chronic Obstructive | 2018 |
The clinical effects of l-arginine and asymmetric dimethylarginine: implications for treatment in secondary Raynaud's phenomenon.
Topics: Arginine; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Raynaud Disease; Scleroderma, Systemic; Vasodilation | 2019 |
Asymmetric dimethylarginine levels in preeclampsia - Systematic review and meta-analysis.
Topics: Arginine; Biomarkers; Female; Humans; Pre-Eclampsia; Pregnancy | 2018 |
Asymmetric dimethylarginine and angiogenesis: biological significance.
Topics: Animals; Arginine; Atherosclerosis; Cardiovascular Diseases; Endothelial Cells; Humans; Neovascularization, Pathologic; Neovascularization, Physiologic; Plaque, Atherosclerotic; Signal Transduction; Up-Regulation | 2018 |
Association of l-Arginine Supplementation with Markers of Endothelial Function in Patients with Cardiovascular or Metabolic Disorders: A Systematic Review and Meta-Analysis.
Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Diabetes Mellitus; Dietary Supplements; Endothelium, Vascular; Female; Humans; Hyperemia; Male; Middle Aged; Nitrates; Nitrites; Obesity; Treatment Outcome | 2018 |
Elevated circulating asymmetric dimethylarginine levels in rheumatoid arthritis: a systematic review and meta-analysis.
Topics: Arginine; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Humans; Risk Factors | 2019 |
An update on arginine in sickle cell disease.
Topics: Anemia, Sickle Cell; Animals; Arginine; Hemolysis; Humans; Nitric Oxide; Nitric Oxide Synthase Type III | 2019 |
Mortality in critical illness: The impact of asymmetric dimethylarginine on survival-A systematic review and meta-analysis.
Topics: Area Under Curve; Arginine; Cause of Death; Critical Illness; Humans; Intensive Care Units; Quality Assurance, Health Care | 2019 |
Relationship between Serum Asymmetric Dimethylarginine Level and Microvascular Complications in Diabetes Mellitus: A Meta-Analysis.
Topics: Arginine; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Female; Humans; Male; Risk Factors | 2019 |
Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases.
Topics: Arginine; Biomarkers; Case-Control Studies; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Rheumatic Diseases | 2019 |
Asymmetric dimethylarginine: An crucial regulator in tissue fibrosis.
Topics: Animals; Arginine; Fibrosis; Humans | 2019 |
Testosterone Deficiency and Endothelial Dysfunction: Nitric Oxide, Asymmetric Dimethylarginine, and Endothelial Progenitor Cells.
Topics: Arginine; Cyclic Nucleotide Phosphodiesterases, Type 5; Endothelial Progenitor Cells; Endothelium, Vascular; Humans; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Testosterone; Vasculitis | 2019 |
Genetic regulation of dimethylarginines and endothelial dysfunction in rheumatoid arthritis.
Topics: Arginine; Arthritis, Rheumatoid; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Endothelium, Vascular; Humans; Inflammation; Nitric Oxide; Nitric Oxide Synthase; Polymorphism, Single Nucleotide; Transaminases | 2019 |
The Role of Nitric Oxide, ADMA, and Homocysteine in The Etiopathogenesis of Preeclampsia-Review.
Topics: Arginine; Female; Homocysteine; Humans; Nitric Oxide; Pre-Eclampsia; Pregnancy; Signal Transduction | 2019 |
New horizons in arginine metabolism, ageing and chronic disease states.
Topics: Aged; Aging; Arginine; Chronic Disease; Homoarginine; Humans | 2019 |
The Biological Axis of Protein Arginine Methylation and Asymmetric Dimethylarginine.
Topics: Animals; Arginine; Humans; Metabolome; Methylation; Protein-Arginine N-Methyltransferases; Proteins | 2019 |
Asymmetric (ADMA) and Symmetric (SDMA) Dimethylarginines in Chronic Kidney Disease: A Clinical Approach.
Topics: Aging; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Metabolic Networks and Pathways; Molecular Targeted Therapy; Prognosis; Renal Dialysis; Renal Insufficiency, Chronic | 2019 |
The Second Life of Methylarginines as Cardiovascular Targets.
Topics: Amidohydrolases; Animals; Arginine; Biological Transport; Biomarkers; Cardiovascular Diseases; Cardiovascular System; Disease Susceptibility; Energy Metabolism; Humans; Molecular Targeted Therapy | 2019 |
Uremic Toxin-Targeting as a Therapeutic Strategy for Preventing Cardiorenal Syndrome.
Topics: Arginine; Cardio-Renal Syndrome; Glycation End Products, Advanced; Humans; Methylamines; Renal Insufficiency, Chronic | 2019 |
Intraplatelet L-Arginine-Nitric Oxide Metabolic Pathway: From Discovery to Clinical Implications in Prevention and Treatment of Cardiovascular Disorders.
Topics: Amidohydrolases; Arginine; Blood Platelets; Cardiovascular Diseases; Endothelium, Vascular; Humans; Metabolic Networks and Pathways; Nitric Oxide; Nitric Oxide Synthase; Risk Factors | 2020 |
Prognostic Value of Asymmetric Dimethylarginine in Patients with Heart Failure: A Systematic Review and Meta-analysis.
Topics: Aged; Arginine; Heart Failure; Humans; Middle Aged; Prognosis | 2020 |
Activation of arginase II by asymmetric dimethylarginine and homocysteine in hypertensive rats induced by hypoxia: a new model of nitric oxide synthesis regulation in hypertensive processes?
Topics: Animals; Arginase; Arginine; Disease Models, Animal; Homocysteine; Hypertension; Hypoxia; Nitric Oxide; Rats; Rats, Wistar | 2021 |
Asymmetric Dimethylarginine: a Key Player in the Pathophysiology of Endothelial Dysfunction, Vascular Inflammation and Atherosclerosis in Rheumatoid Arthritis?
Topics: Arginine; Arthritis, Rheumatoid; Atherosclerosis; Endothelial Cells; Endothelium, Vascular; Humans; Inflammation; Nitric Oxide | 2021 |
Prognostic value of asymmetric dimethylarginine in patients with coronary artery disease: A meta-analysis.
Topics: Arginine; Biomarkers; Coronary Artery Disease; Humans; Prognosis | 2021 |
A systematic review of the correlation between serum asymmetric dimethylarginine, carotid atherosclerosis and ischaemic stroke.
Topics: Arginine; Carotid Artery Diseases; Humans; Ischemic Stroke | 2021 |
Asymmetric dimethylarginine level as biomarkers of cardiovascular or all-cause mortality in patients with chronic kidney disease: a meta-analysis.
Topics: Arginine; Biomarkers; Cardiovascular Diseases; Cause of Death; Humans; Mortality; Renal Insufficiency, Chronic | 2021 |
Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases.
Topics: Antioxidant Response Elements; Antioxidants; Arginine; Cardiotonic Agents; Diabetes Mellitus; Drug Carriers; Drug Compounding; Dyslipidemias; Gene Expression Regulation; Humans; Hypertension; Myocardial Ischemia; Nanocapsules; NF-E2-Related Factor 2; Nitric Oxide; Oxidative Stress; Polyphenols; Signal Transduction | 2021 |
An updated systematic review and meta-analysis of the effect of statins on asymmetric dimethylarginine.
Topics: Arginine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors | 2022 |
A new perspective on NO pathway in sepsis and ADMA lowering as a potential therapeutic approach.
Topics: Animals; Arginine; Humans; Ischemia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Sepsis | 2022 |
Asymmetric dimethylarginine and gestational diabetes mellitus: a systematic review and meta-analysis.
Topics: Arginine; Cardiovascular Diseases; Diabetes, Gestational; Female; Humans; Postpartum Period; Pregnancy | 2023 |
220 trial(s) available for n,n-dimethylarginine and arginine
Article | Year |
---|---|
Concentration of dimethyl-L-arginine in the plasma of patients with end-stage renal failure.
Topics: Adult; Aged; Arginine; Chromatography, High Pressure Liquid; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Uremia | 1996 |
Increased endogenous nitric oxide synthase inhibitor in patients with congestive heart failure.
Topics: Arginine; Echocardiography; Enzyme Inhibitors; Female; Heart Failure; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II | 1998 |
Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia.
Topics: Arginine; Double-Blind Method; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Injections, Intravenous; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Osmolar Concentration; Risk Factors | 1998 |
Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease.
Topics: Aged; Aged, 80 and over; Alprostadil; Arginine; Arterial Occlusive Diseases; Blood Flow Velocity; Chronic Disease; Cyclic GMP; Double-Blind Method; Exercise Test; Female; Femoral Artery; Follow-Up Studies; Humans; Infusions, Intravenous; Intermittent Claudication; Leg; Male; Middle Aged; Nitrates; Nitric Oxide; Peripheral Vascular Diseases; Treatment Outcome; Ultrasonography, Doppler, Duplex; Vasodilation; Vasodilator Agents | 1998 |
Asymmetric dimethylarginine plasma concentrations differ in patients with end-stage renal disease: relationship to treatment method and atherosclerotic disease.
Topics: Adult; Aged; Analysis of Variance; Arginine; Arteriosclerosis; Female; Humans; Kidney Failure, Chronic; Kidney Function Tests; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Prognosis; Reference Values; Renal Dialysis; Severity of Illness Index | 1999 |
Effects of some guanidino compounds on human cerebral arteries.
Topics: Adult; Aged; Arginine; Enzyme Inhibitors; Female; Guanidines; Humans; Male; Methylguanidine; Middle Aged; Middle Cerebral Artery; Nitric Oxide Synthase; omega-N-Methylarginine; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
Acute elevations of plasma asymmetric dimethylarginine and impaired endothelial function in response to a high-fat meal in patients with type 2 diabetes.
Topics: Adult; Aged; Arginine; Diabetes Mellitus, Type 2; Dietary Fats; Endothelium, Vascular; Female; Humans; Lipids; Male; Middle Aged; Triglycerides; Vasodilation | 2000 |
Endothelium-dependent vasodilation is independent of the plasma L-arginine/ADMA ratio in men with stable angina: lack of effect of oral L-arginine on endothelial function, oxidative stress and exercise performance.
Topics: Administration, Oral; Angina Pectoris; Arginine; Dinoprost; Double-Blind Method; Endothelium, Vascular; Exercise; Exercise Test; F2-Isoprostanes; Forearm; Heart Rate; Humans; Injections, Intra-Arterial; Male; Middle Aged; Oxidative Stress; Regional Blood Flow; Vasodilation | 2001 |
Metformin treatment lowers asymmetric dimethylarginine concentrations in patients with type 2 diabetes.
Topics: Arginine; Blood Glucose; Creatinine; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Sulfonylurea Compounds; Treatment Outcome | 2002 |
Angiotensin converting enzyme inhibition and angiotensin II AT1-receptor blockade reduce the levels of asymmetrical N(G), N(G)-dimethylarginine in human essential hypertension.
Topics: Acrylates; Adult; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arginine; Blood Pressure; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Enalapril; Endothelium, Vascular; Humans; Hypertension; Imidazoles; Male; Receptor, Angiotensin, Type 1; Thiophenes | 2002 |
Relationship between salt intake, nitric oxide and asymmetric dimethylarginine and its relevance to patients with end-stage renal disease.
Topics: Arginine; Blood Pressure; Cardiovascular Diseases; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Renal Dialysis; Risk Factors; Sodium Chloride | 2002 |
Long-term angiotensin-converting enzyme inhibition reduces plasma asymmetric dimethylarginine and improves endothelial nitric oxide bioavailability and coronary microvascular function in patients with syndrome X.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Arginine; Biological Availability; Coronary Circulation; Double-Blind Method; Enalapril; Endothelium, Vascular; Exercise Test; Female; Hemodynamics; Humans; Male; Microcirculation; Microvascular Angina; Middle Aged; Nitric Oxide; Statistics as Topic; Time; Treatment Outcome; von Willebrand Factor | 2002 |
ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins.
Topics: Aged; Analysis of Variance; Arginine; Arterial Occlusive Diseases; Double-Blind Method; Female; Folic Acid; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nitric Oxide Synthase; Oxidative Stress; Peripheral Vascular Diseases; Vitamin B 12; Vitamin B 6; Vitamins | 2003 |
Increased levels of asymmetric dimethylarginine in populations at risk for atherosclerotic disease. Effects of pravastatin.
Topics: Arginine; Arteriosclerosis; Cholesterol, LDL; Diabetes Mellitus, Type 1; Female; Humans; Hypercholesterolemia; Incidence; Male; Pravastatin; Predictive Value of Tests; Probability; Reference Values; Risk Assessment; Sensitivity and Specificity | 2003 |
Effect of high-dose statin treatment on plasma concentrations of endogenous nitric oxide synthase inhibitors.
Topics: Aged; Analysis of Variance; Arginine; Azo Compounds; Chi-Square Distribution; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Nitric Oxide Synthase | 2003 |
Acute intravenous L-arginine infusion decreases endothelin-1 levels and improves endothelial function in patients with angina pectoris and normal coronary arteriograms: correlation with asymmetric dimethylarginine levels.
Topics: Angina Pectoris; Arginine; Blood Pressure; Coronary Angiography; Cyclic GMP; Endothelin-1; Endothelium, Vascular; Female; Forearm; Humans; Infusions, Intravenous; Insulin; Male; Middle Aged; Nitric Oxide; Regional Blood Flow; Syndrome | 2003 |
Oestrogen replacement therapy lowers plasma levels of asymmetrical dimethylarginine in healthy postmenopausal women.
Topics: Analysis of Variance; Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Double-Blind Method; Estrogen Replacement Therapy; Estrogens, Conjugated (USP); Female; Humans; Hysterectomy; Middle Aged; Nitric Oxide Synthase; Postmenopause; Protein Isoforms; Raloxifene Hydrochloride; Risk Factors; Selective Estrogen Receptor Modulators; Sensitivity and Specificity | 2003 |
Folic acid treatment reduces elevated plasma levels of asymmetric dimethylarginine in hyperhomocysteinaemic subjects.
Topics: Adult; Aged; Arginine; Biomarkers; Dietary Supplements; Enzyme Inhibitors; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nitric Oxide Synthase | 2003 |
Effects of simvastatin and L-arginine on vasodilation, nitric oxide metabolites and endogenous NOS inhibitors in hypercholesterolemic subjects.
Topics: Anticholesteremic Agents; Arginine; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Free Radicals; Humans; Hypercholesterolemia; Lipids; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; S-Nitrosothiols; Simvastatin; Time Factors; Vasodilation | 2003 |
Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase.
Topics: Adult; Amidohydrolases; Arginine; Blood Pressure; Cardiac Output; Double-Blind Method; Heart Rate; Humans; Hypertension; Injections, Intravenous; Male; Vascular Resistance | 2003 |
Hyperhomocysteinaemia is not associated with increased levels of asymmetric dimethylarginine in patients with ischaemic heart disease.
Topics: Adult; Arginine; Female; Folic Acid; Humans; Hyperhomocysteinemia; Male; Middle Aged; Myocardial Ischemia; Nitric Oxide Synthase; Pyridoxine; Vitamin B 12 | 2003 |
Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine.
Topics: Adult; Age Factors; Aged; Arginine; Arteriosclerosis; Brachial Artery; Endothelium, Vascular; Female; Homocysteine; Homocystine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Peripheral Vascular Diseases; Regional Blood Flow; Regression Analysis; Vasodilation | 2003 |
Increased concentrations of homocysteine and asymmetric dimethylarginine and decreased concentrations of nitric oxide in the plasma of patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Arginine; Enzyme Inhibitors; Female; Homocysteine; Humans; Male; Matched-Pair Analysis; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Reference Values; Statistics as Topic | 2003 |
Effect of hormone replacement therapy on plasma levels of the cardiovascular risk factor asymmetric dimethylarginine: a randomized, placebo-controlled 12-week study in healthy early postmenopausal women.
Topics: Arginine; Biomarkers; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Dydrogesterone; Estradiol; Estrogen Replacement Therapy; Female; Humans; Isomerism; Middle Aged; Progesterone Congeners; Promegestone; Risk Factors; Spectrometry, Fluorescence | 2003 |
Impact of vitamin E on plasma asymmetric dimethylarginine (ADMA) in chronic kidney disease (CKD): a pilot study.
Topics: Adult; Aged; alpha-Tocopherol; Antioxidants; Arginine; Chronic Disease; Female; Humans; Kidney; Kidney Diseases; Male; Middle Aged; Oxidative Stress; Pilot Projects | 2003 |
Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans.
Topics: Arginine; Cardiac Output; Cross-Over Studies; Cyclic GMP; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Hemodynamics; Humans; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Vascular Resistance | 2004 |
Asymmetrical dimethylarginine (ADMA) and risk of acute coronary events. Does statin treatment influence plasma ADMA levels?
Topics: Acute Disease; Adult; Aged; Arginine; Atorvastatin; Biomarkers; Blood Glucose; Case-Control Studies; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Double-Blind Method; Endothelium, Vascular; Enzyme Inhibitors; Female; Finland; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Male; Middle Aged; Prospective Studies; Pyrroles; Risk Factors; Simvastatin; Statistics as Topic; Triglycerides | 2003 |
Acute Escherichia coli endotoxaemia decreases the plasma l-arginine/asymmetrical dimethylarginine ratio in humans.
Topics: Acute Disease; Arginine; Blood Pressure; Body Temperature; Double-Blind Method; Endotoxemia; Escherichia coli Infections; Heart Rate; Humans; Leukocyte Count; Lipopolysaccharides; Male; Nitric Oxide Synthase | 2004 |
Plasma asymmetric dimethylarginine modifies the effect of pravastatin on myocardial blood flow in young adults.
Topics: Adenosine; Adult; Anticholesteremic Agents; Arginine; Blood Flow Velocity; Coronary Circulation; Double-Blind Method; Enzyme Inhibitors; Humans; Hyperemia; Male; Nitric Oxide Synthase; Pravastatin; Regional Blood Flow; Tomography, Emission-Computed | 2003 |
Fenofibrate increases the L-arginine:ADMA ratio by increase of L-arginine concentration but has no effect on ADMA concentration.
Topics: Adult; Arginine; Biomarkers; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Fenofibrate; Follow-Up Studies; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Probability; Reference Values; Risk Assessment; Severity of Illness Index; Treatment Outcome | 2004 |
Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Arginine; Captopril; Enalapril; Female; Humans; Hypertension; Lipid Peroxidation; Lipoproteins, LDL; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Oxidative Stress | 2004 |
Asymmetric dimethyl arginine and symmetric dimethyl arginine levels in infants with persistent pulmonary hypertension of the newborn.
Topics: Arginine; Chromatography, High Pressure Liquid; Cohort Studies; Female; Humans; Hypertension, Pulmonary; Infant, Newborn; Intensive Care Units, Pediatric; Male; Nitric Oxide Synthase | 2004 |
Elevated plasma concentration of asymmetric dimethylarginine that is reduced by single dose testosterone administration in idiopathic hypogonadotropic hypogonadism patients.
Topics: Adult; Androgens; Arginine; Humans; Hypogonadism; Male; Nitrates; Nitric Oxide; Nitrites; Testosterone | 2005 |
Home-based exercise training modulates pro-oxidant substrates in patients with chronic heart failure.
Topics: Adult; Arginine; Cross-Over Studies; Exercise; Female; Heart Failure; Humans; Hypoxanthine; Male; Middle Aged; Nitrates; Nitrites; Xanthine | 2005 |
L-arginine improves the symptoms of strokelike episodes in MELAS.
Topics: Administration, Oral; Adolescent; Adult; Amino Acids; Arginine; Cerebral Arteries; Child; Child, Preschool; Cholesterol; Cyclic GMP; Female; Headache; Humans; Male; MELAS Syndrome; Nitric Oxide; Paresis; Seizures; Stroke; Treatment Outcome; Vasodilation; Vision Disorders; Vomiting | 2005 |
Modulation of asymmetric dimethylarginine in critically ill patients receiving intensive insulin treatment: a possible explanation of reduced morbidity and mortality?
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Arginine; Critical Illness; Female; Humans; Insulin; Male; Middle Aged; Morbidity; Nitric Oxide Synthase; Prospective Studies; Regression Analysis; Risk Factors; Survival Rate | 2005 |
[Changes of serum asymmetric dimethylarginine in essential hypertension before and after the treatment].
Topics: Adult; Aged; Antihypertensive Agents; Arginine; Enalapril; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase | 2005 |
Plasma asymmetric dimethylarginine (ADMA) concentration is independently associated with carotid intima-media thickness and plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) concentration in patients with mild-to-moderate renal failure.
Topics: Adult; Aged; Antioxidants; Arginine; Biomarkers; C-Reactive Protein; Carotid Artery Diseases; Female; Homocysteine; Humans; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Oxidative Stress; Solubility; Tunica Intima; Tunica Media; Ultrasonography; Vascular Cell Adhesion Molecule-1 | 2005 |
Long-term use of vitamin E-coated polysulfone membrane reduces oxidative stress markers in haemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Arginine; Biomarkers; Coated Materials, Biocompatible; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic; Lipoproteins, LDL; Male; Membranes, Artificial; Middle Aged; Nitric Oxide Synthase; Oxidative Stress; Polymers; Prognosis; Renal Dialysis; Sulfones; Time Factors; Vitamin E | 2005 |
Dissociation between the short-term effects of nocturnal hemodialysis on endothelium dependent vasodilation and plasma ADMA.
Topics: Adult; Appointments and Schedules; Arginine; Circadian Rhythm; Endothelium, Vascular; Female; Humans; Kidney Failure, Chronic; Male; Renal Dialysis; Vasodilation | 2005 |
Free fatty acids do not acutely increase asymmetrical dimethylarginine concentrations.
Topics: Adult; Arginine; Blood Pressure; Endothelial Cells; Endothelium, Vascular; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Humans; Insulin Resistance; Male; Reference Values; Statistics, Nonparametric; Umbilical Veins | 2005 |
Effect of fenofibrate on the level of asymmetric dimethylarginine in individuals with hypertriglyceridemia.
Topics: Adult; Anticholesteremic Agents; Arginine; Blood Flow Velocity; Brachial Artery; Cholesterol; Cholesterol, HDL; Diet; Endothelium, Vascular; Female; Fenofibrate; Humans; Hypertriglyceridemia; Male; Malondialdehyde; Middle Aged; Nitric Oxide; Treatment Outcome; Triglycerides; Tumor Necrosis Factor-alpha; Vasodilation | 2006 |
No effect of B vitamins on ADMA levels in patients at increased cardiovascular risk.
Topics: Adolescent; Adult; Arginine; Atherosclerosis; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Female; Folic Acid; Humans; Hyperhomocysteinemia; Linear Models; Male; Middle Aged; Pyridoxine; Risk Factors; Time Factors; Treatment Failure; Vitamin B Complex | 2006 |
Plasma markers of NO synthase activity in women after ovarian hyperstimulation: influence of estradiol on ADMA.
Topics: Adult; Arginine; Cells, Cultured; Endothelial Cells; Estradiol; Female; Follicle Stimulating Hormone; Follicular Phase; Humans; Luteinizing Hormone; Nitrates; Nitric Oxide Synthase; Nitrites; Ovulation Induction; Recombinant Proteins | 2006 |
ADMA increases arterial stiffness and decreases cerebral blood flow in humans.
Topics: Adult; Arginine; Cerebral Arteries; Cerebrovascular Circulation; Compliance; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Humans; Injections, Intravenous; Magnetic Resonance Imaging; Male; Nitric Oxide Synthase; Reference Values; Vasomotor System | 2006 |
Effects of combined supplementation with B vitamins and antioxidants on plasma levels of asymmetric dimethylarginine (ADMA) in subjects with elevated risk for cardiovascular disease.
Topics: Adult; Aged; Antioxidants; Arginine; Cardiovascular Diseases; Double-Blind Method; Female; Humans; Lipids; Male; Middle Aged; Risk Factors; Vitamin B Complex | 2007 |
Daily consumption for six weeks of a lignan complex isolated from flaxseed does not affect endothelial function in healthy postmenopausal women.
Topics: 4-Butyrolactone; Aged; Arginine; Blood Pressure; Body Weight; Cross-Over Studies; Diet; Double-Blind Method; Endothelin-1; Endothelium, Vascular; Female; Flax; Humans; Lignans; Middle Aged; Nitrates; Nitrites; Nitroglycerin; Patient Compliance; Placebos; Postmenopause; Vasodilation | 2006 |
Effect of iloprost on plasma asymmetric dimethylarginine and plasma and platelet serotonin in patients with peripheral arterial occlusive disease.
Topics: Aged; Aged, 80 and over; Arginine; Arterial Occlusive Diseases; Blood Platelets; Blood Pressure; Diabetes Mellitus, Type 2; Drug Administration Schedule; Exercise Test; Female; Humans; Iloprost; Infusions, Intravenous; Male; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Serotonin; Treatment Outcome | 2006 |
No benefit of hemodiafiltration over hemodialysis in lowering elevated levels of asymmetric dimethylarginine in ESRD patients.
Topics: Adult; Aged; Arginine; beta 2-Microglobulin; Female; Hemodiafiltration; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase | 2006 |
Effects of amlodipine and valsartan on oxidative stress and plasma methylarginines in end-stage renal disease patients on hemodialysis.
Topics: Adult; Aged; Aged, 80 and over; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Arginine; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Female; Humans; Hypertension, Renal; Kidney Failure, Chronic; Male; Methylation; Middle Aged; Oxidative Stress; Renal Dialysis; Tetrazoles; Valine; Valsartan | 2006 |
Pioglitazone improves endothelial function in non-diabetic patients with coronary artery disease.
Topics: Adult; Aged; Arginine; Blood Sedimentation; Brachial Artery; C-Reactive Protein; Cardiovascular Agents; Coronary Artery Disease; Endothelium, Vascular; Fibrinogen; Humans; Lipids; Male; Middle Aged; Pioglitazone; PPAR gamma; Prospective Studies; Thiazolidinediones | 2007 |
Changes of plasma asymmetric dimethylarginine levels after coronary artery bypass grafting.
Topics: Arginine; Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Disease; Female; Heart Arrest, Induced; Humans; Hyperoxia; Male; Middle Aged; Myocardium; Postoperative Period; Time Factors | 2006 |
Effects of alpha-lipoic acid on the plasma levels of asymmetric dimethylarginine in diabetic end-stage renal disease patients on hemodialysis: a pilot study.
Topics: Adult; Antioxidants; Arginine; Biomarkers; C-Reactive Protein; Cholesterol; Chromatography, High Pressure Liquid; Diabetic Nephropathies; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Kidney Failure, Chronic; Lipoproteins, LDL; Male; Middle Aged; Nitric Oxide Synthase; Oxidation-Reduction; Pilot Projects; Renal Dialysis; Thioctic Acid; Treatment Outcome | 2007 |
Beneficial metabolic effects of nateglinide versus acarbose in patients with newly-diagnosed type 2 diabetes.
Topics: Acarbose; Arginine; Blood Glucose; Cross-Over Studies; Cyclohexanes; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin; Lipids; Male; Middle Aged; Nateglinide; Phenylalanine; Prospective Studies | 2007 |
The administration of estrogens, combined with anti-androgens, has beneficial effects on the hormonal features and asymmetric dimethyl-arginine levels, in women with the polycystic ovary syndrome.
Topics: Adult; Androgen Antagonists; Arginine; Cyproterone Acetate; Desogestrel; Drug Therapy, Combination; Endothelin-1; Estradiol; Estrogens; Estrogens, Conjugated (USP); Ethinyl Estradiol; Female; Hormones; Humans; Insulin Resistance; Polycystic Ovary Syndrome | 2008 |
Effects of a supplement containing isoflavones and Actaea racemosa L. on asymmetric dimethylarginine, lipids, and C-reactive protein in menopausal women.
Topics: Aged; Arginine; C-Reactive Protein; Cholesterol, LDL; Cimicifuga; Coronary Disease; Double-Blind Method; Female; Humans; Isoflavones; Lipids; Menopause; Sample Size | 2007 |
Asymmetric dimethylarginine determines the improvement of endothelium-dependent vasodilation by simvastatin: Effect of combination with oral L-arginine.
Topics: Aged; Aged, 80 and over; Arginine; C-Reactive Protein; Drug Therapy, Combination; Endothelium, Vascular; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins; Male; Middle Aged; Nitric Oxide Synthase Type III; Simvastatin; Vasodilation | 2007 |
Improvement in central arterial pressure waveform during hemodialysis is related to a reduction in asymmetric dimethylarginine (ADMA) levels.
Topics: Aged; Arginine; Blood Pressure; Female; Humans; Kidney Failure, Chronic; Male; Renal Dialysis | 2007 |
Hyperbaric oxygen therapy mediates increased nitric oxide production associated with wound healing: a preliminary study.
Topics: Arginine; Chromatography, High Pressure Liquid; Chronic Disease; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Exudates and Transudates; Fasting; Female; Granulation Tissue; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Nitric Oxide; Oxidation-Reduction; Time Factors; Treatment Outcome; Wound Healing; Wounds and Injuries | 2007 |
Plasma dimethylarginine levels in chronic hemodialysis patients are independent of the type of dialyzer applied.
Topics: Adult; Aged; Aged, 80 and over; Arginine; beta 2-Microglobulin; Biocompatible Materials; Complement C3a; Cross-Over Studies; Equipment Design; Female; Humans; Kidney Failure, Chronic; Male; Membranes, Artificial; Middle Aged; Nitric Oxide; Prospective Studies; Renal Dialysis | 2007 |
Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.
Topics: Administration, Oral; Arginine; Citrulline; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Placebos; Vasodilation | 2008 |
Improving proteinuria, endothelial functions and asymmetric dimethylarginine levels in chronic kidney disease: ramipril versus valsartan.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Arginine; Biomarkers; Blood Glucose; C-Reactive Protein; Female; Glomerular Filtration Rate; Hemorheology; Humans; Insulin Resistance; Kidney Failure, Chronic; Lipids; Male; Middle Aged; Proteinuria; Ramipril; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan; Vasodilation | 2007 |
Obstructive sleep apnea and endothelial function in school-aged nonobese children: effect of adenotonsillectomy.
Topics: Adenoidectomy; Arginine; Body Weight; CD40 Ligand; Child; Endothelium, Vascular; Female; Humans; Hyperemia; Hypoxia; Male; Nitric Oxide; Polysomnography; Sleep Apnea, Obstructive; Tonsillectomy; Tyrosine; Vasculitis | 2007 |
Temporal effects of low-dose ACE inhibition on endothelial function in Type 1 diabetic patients.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Arginine; Diabetes Mellitus, Type 1; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Humans; Indoles; Male; Oxidative Stress; Thiobarbituric Acid Reactive Substances; Vasodilation | 2007 |
Effect of telmisartan on forearm postischemic hyperemia and serum asymmetric dimethylarginine levels.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Arginine; Benzimidazoles; Benzoates; Blood Pressure; Endothelium, Vascular; Female; Forearm; Humans; Hyperemia; Hypertension; Male; Middle Aged; Telmisartan; Tetrazoles; Valine; Valsartan | 2007 |
Rosiglitazone improves endothelial function and inflammation but not asymmetric dimethylarginine or oxidative stress in patients with type 2 diabetes mellitus.
Topics: Adult; Aged; Arginine; Biomarkers; Blood Glucose; Blood Pressure; Brachial Artery; C-Reactive Protein; Carotid Arteries; Diabetes Mellitus; Double-Blind Method; Drug Therapy, Combination; Elasticity; Endothelium, Vascular; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Inflammation; Insulin; Male; Metformin; Middle Aged; Oxidative Stress; Rosiglitazone; Thiazolidinediones; Treatment Outcome; Vasodilation | 2007 |
Effects of normalization of plasma testosterone levels in hypogonadal men on plasma levels and urinary excretion of asymmetric dimethylarginine (ADMA).
Topics: Adult; Aged; Arginine; Body Mass Index; Humans; Hypogonadism; Male; Middle Aged; Nitrates; Nitrites; Testosterone | 2008 |
The effects of renal replacement therapy on plasma, asymmetric dimethylarginine, nitric oxide and C-reactive protein levels.
Topics: Adult; Arginine; Atherosclerosis; C-Reactive Protein; Endothelium, Vascular; Female; Humans; Inflammation; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Peritoneal Dialysis, Continuous Ambulatory; Risk Factors; Time Factors | 2008 |
Metformin, arterial function, intima-media thickness and nitroxidation in metabolic syndrome: the mefisto study.
Topics: Adult; Arginine; Carotid Arteries; Female; Humans; Hypoglycemic Agents; Male; Metabolic Syndrome; Metformin; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Tunica Intima | 2008 |
Asymmetric dimethylarginine and the effect of folate substitution in children with familial hypercholesterolemia and diabetes mellitus type 1.
Topics: Adolescent; Anticholesteremic Agents; Arginine; Azetidines; Biomarkers; Child; Diabetes Mellitus, Type 1; Drug Therapy, Combination; Endothelium, Vascular; Ezetimibe; Female; Folic Acid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Lipoproteins, LDL; Male; Risk Factors; Ultrasonography; Vitamin B Complex | 2009 |
Acute effects of passive smoking on peripheral vascular function.
Topics: Acute Disease; Administration, Sublingual; Adult; Aorta; Arginine; Blood Pressure; Carboxyhemoglobin; Cross-Over Studies; Endothelium, Vascular; Environmental Exposure; Heart Rate; Humans; Male; Nicotine; Nicotinic Agonists; Nitric Oxide; Nitric Oxide Synthase; Regional Blood Flow; Skin; Tobacco Smoke Pollution | 2008 |
Effect of atorvastatin on plasma levels of asymmetric dimethylarginine in patients with non-ischaemic heart failure.
Topics: Arginine; Atorvastatin; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Heart Failure; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pyrroles; Ventricular Dysfunction, Left | 2008 |
Antiproteinuric effects of angiotensin receptor blockers: telmisartan versus valsartan in hypertensive patients with type 2 diabetes mellitus and overt nephropathy.
Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Arginine; Benzimidazoles; Benzoates; Blood Pressure; C-Reactive Protein; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dinoprost; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Prospective Studies; Proteinuria; Renin-Angiotensin System; Telmisartan; Tetrazoles; Valine; Valsartan | 2008 |
Short term fluvastatin treatment lowers serum asymmetric dimethylarginine levels in patients with metabolic syndrome.
Topics: Adult; Arginine; Cholesterol; Endothelium, Vascular; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Male; Metabolic Syndrome; Middle Aged; Treatment Outcome | 2008 |
Asymmetric dimethylarginine concentration and early recurrence of atrial fibrillation after electrical cardioversion.
Topics: Aged; Arginine; Atrial Fibrillation; Biomarkers; Electric Countershock; Female; Humans; Male; Middle Aged; Prognosis; Reproducibility of Results; Secondary Prevention; Sensitivity and Specificity; Treatment Outcome | 2008 |
Nebivolol treatment reduces serum levels of asymmetric dimethylarginine and improves endothelial dysfunction in essential hypertensive patients.
Topics: Adrenergic beta-Antagonists; Aged; Amidohydrolases; Antihypertensive Agents; Arginine; Atenolol; Benzopyrans; Double-Blind Method; Endothelium, Vascular; Ethanolamines; Female; Humans; Hypertension; Male; Middle Aged; Nebivolol; Nitric Oxide Synthase Type III; Vasodilation | 2008 |
Randomized placebo-controlled trial assessing a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on plasma asymmetric dimethylarginine concentration in mild to moderate CKD.
Topics: Adult; Aged; Anticholesteremic Agents; Arginine; Carotid Arteries; Chronic Disease; Creatinine; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Kidney Diseases; Lipoproteins, LDL; Male; Middle Aged; Pravastatin; Vitamin B 12; Vitamin B 6; Vitamin E | 2009 |
Effect of nitrous oxide anesthesia on plasma homocysteine and endothelial function.
Topics: Aged; Anesthetics, Inhalation; Arginine; Endothelium, Vascular; Female; Homocysteine; Humans; Male; Middle Aged; Nitrous Oxide; Oxidative Stress; Prospective Studies; Time Factors | 2008 |
Reduction of plasma asymmetric dimethylarginine in obese patients with chronic kidney disease after three years of a low-protein diet supplemented with keto-amino acids: a randomized controlled trial.
Topics: Adult; Aged; Amino Acids; Arginine; Combined Modality Therapy; Diet, Protein-Restricted; Dietary Supplements; Female; Humans; Keto Acids; Kidney Failure, Chronic; Male; Middle Aged; Obesity; Treatment Outcome; Young Adult | 2008 |
Effects of growth hormone treatment on arginine to asymmetric dimethylarginine ratio and endothelial function in patients with growth hormone deficiency.
Topics: Adiposity; Adolescent; Adult; Arginine; Body Weight; Endothelium, Vascular; Female; Growth Disorders; Hormone Replacement Therapy; Human Growth Hormone; Humans; Insulin-Like Growth Factor I; Lipids; Male; Middle Aged; Waist Circumference; Young Adult | 2008 |
Endothelial function and insulin resistance in polycystic ovary syndrome: the effects of medical therapy.
Topics: Adult; Arginine; Biomarkers; Blood Glucose; C-Reactive Protein; Contraceptives, Oral, Combined; Contraceptives, Oral, Hormonal; Cyproterone Acetate; Drug Therapy, Combination; Endothelium, Vascular; Ethinyl Estradiol; Female; Humans; Hyperandrogenism; Hypoglycemic Agents; Inflammation Mediators; Insulin; Insulin Resistance; Lipids; Metformin; Plasminogen Activator Inhibitor 1; Polycystic Ovary Syndrome; Sex Hormone-Binding Globulin; Testosterone; Time Factors; Treatment Outcome; Vasodilation; von Willebrand Factor | 2010 |
Study of the correlation between clinical efficiency of impaza and serum ADMA level.
Topics: Adult; Antibodies; Arginine; Double-Blind Method; Erectile Dysfunction; Humans; Male; Nitric Oxide Synthase Type III | 2008 |
Endothelial dysfunction, ADMA and insulin resistance in essential hypertension.
Topics: Acetylcholine; Adult; Arginine; Case-Control Studies; Endothelium, Vascular; Female; Homeostasis; Humans; Hypertension; Insulin Resistance; Male; Middle Aged; Nitric Oxide Synthase Type III; Nitroprusside; Regional Blood Flow; Risk Factors; Vasodilator Agents | 2010 |
The effects of G-CSF-induced mobilization of progenitor cells are limited by ADMA.
Topics: Aged; Aged, 80 and over; Angina Pectoris; Antioxidants; Arginine; Cells, Cultured; Chromans; Coronary Disease; Endothelial Cells; Female; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Humans; Leukocytosis; Male; Middle Aged; Oxidative Stress; Peroxidase; Umbilical Veins | 2010 |
Ranolazine improves endothelial function in patients with stable coronary artery disease.
Topics: Acetanilides; Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Agents; Coronary Artery Disease; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Humans; Hyperemia; Inflammation Mediators; Male; Manometry; Middle Aged; Piperazines; Ranolazine; Time Factors; Treatment Outcome; Vasodilation | 2009 |
The effect of rosiglitazone on asymmetric dimethylarginine (ADMA) in critically ill patients.
Topics: Aged; Arginine; Critical Illness; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pilot Projects; Rosiglitazone; Thiazolidinediones | 2009 |
Co-administration of ezetimibe enhances proteinuria-lowering effects of pitavastatin in chronic kidney disease patients partly via a cholesterol-independent manner.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Anticholesteremic Agents; Arginine; Azetidines; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Deoxyguanosine; Drug Therapy, Combination; Dyslipidemias; Ezetimibe; Fatty Acid-Binding Proteins; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Diseases; Male; Middle Aged; Proteinuria; Quinolines; Severity of Illness Index; Treatment Outcome; Triglycerides | 2010 |
Acute effects of 5-methyltetrahydrofolate on endothelial function and asymmetric dimethylarginine in patients with chronic heart failure.
Topics: Aged; Arginine; Chronic Disease; Endothelium, Vascular; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Tetrahydrofolates | 2010 |
Postprandial vascular effects of VIAject compared with insulin lispro and regular human insulin in patients with type 2 diabetes.
Topics: Arginine; Blood Glucose; Blood Vessels; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Injections, Subcutaneous; Insulin; Insulin Lispro; Male; Microcirculation; Middle Aged; Postprandial Period; Tyrosine | 2010 |
Effects of an exercise intervention using Dance Dance Revolution on endothelial function and other risk factors in overweight children.
Topics: Arginine; Biomarkers; Blood Glucose; Blood Pressure; Body Height; Body Mass Index; Body Weight; Brachial Artery; Child; Dance Therapy; Endothelium, Vascular; Exercise Therapy; Female; Humans; Inflammation Mediators; Insulin; Lipids; Male; Nitrates; Nitrites; Overweight; Oxygen Consumption; Patient Compliance; Physical Fitness; Risk Factors; Time Factors; Treatment Outcome; Ultrasonography; Vasodilation; Video Games | 2009 |
Treatment with alpha-lipoic acid reduces asymmetric dimethylarginine in patients with type 2 diabetes mellitus.
Topics: Arginine; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Male; Middle Aged; Thioctic Acid | 2010 |
Effect of genistein therapy on plasma levels of asymmetric dimethylarginine in healthy postmenopausal women: a randomized, placebo-controlled study.
Topics: Adult; Arginine; Atherosclerosis; Female; Genistein; Humans; Middle Aged; Phytoestrogens; Placebos; Postmenopause; Reference Values; Risk Factors | 2010 |
Prophylactics of erectile dysfunction in patients with metabolic syndrome.
Topics: Adult; Aged; Antibodies; Antihypertensive Agents; Arginine; Erectile Dysfunction; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Male; Metabolic Syndrome; Middle Aged | 2009 |
Postprandial hyperglycemia is a determinant of platelet activation in early type 2 diabetes mellitus.
Topics: Acarbose; Aged; Arginine; Biomarkers; Blood Glucose; C-Reactive Protein; CD40 Ligand; Diabetes Mellitus, Type 2; Dinoprost; Double-Blind Method; Enzyme Inhibitors; Female; Glycated Hemoglobin; Glycoside Hydrolase Inhibitors; Humans; Hyperglycemia; Hypoglycemic Agents; Italy; Lipid Peroxidation; Male; Middle Aged; P-Selectin; Platelet Activation; Postprandial Period; Thromboxane B2; Time Factors; Treatment Outcome | 2010 |
Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailability.
Topics: AC133 Antigen; Adult; Alcoholic Beverages; Antigens, CD; Antigens, CD34; Arginine; Beer; Biological Availability; Biomarkers; Cell Adhesion; Cell Movement; Cell Proliferation; Cells, Cultured; Cellular Senescence; Endothelial Cells; Enzyme Inhibitors; Ethanol; Female; Flow Cytometry; Glycoproteins; Humans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Peptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Prospective Studies; Proto-Oncogene Proteins c-akt; Resveratrol; Stem Cells; Stilbenes; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor Receptor-2; Vasodilation; Wine | 2010 |
Green tea catechins improve human forearm endothelial dysfunction and have antiatherosclerotic effects in smokers.
Topics: Acetylcholine; Adult; Arginine; Atherosclerosis; C-Reactive Protein; Catechin; CD40 Ligand; Chemokine CCL2; Endothelium, Vascular; Forearm; Humans; Male; Malondialdehyde; Nitroprusside; Oxidative Stress; Plant Extracts; Smoking; Tea; Vasodilation; Vasodilator Agents | 2010 |
Robotic treadmill training improves cardiovascular function in spinal cord injury patients.
Topics: Adult; Aged; Arginine; Cardiovascular Physiological Phenomena; Coronary Circulation; Diastole; Echocardiography; Endothelium, Vascular; Exercise Therapy; Female; Humans; Male; Middle Aged; Physical Fitness; Robotics; Spinal Cord Injuries; Ventricular Function, Left | 2011 |
Effect of moderate and high-dose simvastatin on asymmetric dimethylarginine-homocysteine metabolic pathways in patients with newly detected severe hypercholesterolemia.
Topics: Adult; Arginine; Biomarkers; Bulgaria; Cholesterol, LDL; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Prospective Studies; Severity of Illness Index; Simvastatin; Time Factors; Treatment Outcome | 2011 |
Effect of supplementation with B vitamins and antioxidants on levels of asymmetric dimethylarginine (ADMA) and C-reactive protein (CRP): a double-blind, randomised, factorial design, placebo-controlled trial.
Topics: Adult; Antioxidants; Arginine; Ascorbic Acid; beta Carotene; Biomarkers; Blood Pressure; C-Reactive Protein; Cardiovascular Diseases; Cholesterol; Dietary Supplements; Double-Blind Method; Homocysteine; Humans; Male; Middle Aged; Protective Agents; Triglycerides; Vitamin B Complex; Vitamin E | 2010 |
Randomized controlled trial of the effect of short-term coadministration of methylcobalamin and folate on serum ADMA concentration in patients receiving long-term hemodialysis.
Topics: Administration, Oral; Aged; Arginine; Cardiovascular Diseases; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Injections, Intravenous; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Risk Factors; Vitamin B 12; Vitamin B Complex | 2010 |
Asymmetric dimethylarginine correlates with measures of disease severity, major adverse cardiovascular events and all-cause mortality in patients with peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Ankle Brachial Index; Arginine; Blood Glucose; Creatinine; Exercise Test; Female; Follow-Up Studies; Humans; Insulin; Lipids; Male; Middle Aged; Peripheral Arterial Disease; Risk Factors; Severity of Illness Index | 2010 |
N-3 polyunsaturated fatty acids early supplementation improves ultrasound indices of endothelial function, but not through NO inhibitors in patients with acute myocardial infarction: N-3 PUFA supplementation in acute myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Arginine; Blood Flow Velocity; Dietary Supplements; Dilatation, Pathologic; Endothelium, Vascular; Fatty Acids, Omega-3; Female; Humans; Linear Models; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Prospective Studies; Treatment Outcome; Ultrasonography | 2011 |
The differences of asymmetric dimethylarginine removal by different dialysis treatments.
Topics: Adult; Age Factors; Aged; Arginine; Dialysis Solutions; Female; Glomerular Filtration Rate; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Risk Factors | 2010 |
Simvastatin and asymmetric dimethylarginine-homocysteine metabolic pathways in patients with newly detected severe hypercholesterolemia.
Topics: Adult; Anticholesteremic Agents; Arginine; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Homocysteine; Humans; Hypercholesterolemia; Lipids; Male; Simvastatin; Treatment Outcome | 2010 |
Symmetrical and asymmetrical dimethylarginine as predictors for mortality in patients referred for coronary angiography: the Ludwigshafen Risk and Cardiovascular Health study.
Topics: Aged; Arginine; Biomarkers; Cardiovascular Diseases; Coronary Angiography; Coronary Disease; Female; Humans; Linear Models; Male; Middle Aged; Mortality; Predictive Value of Tests; Prognosis; Renal Insufficiency; Risk Factors | 2011 |
Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men.
Topics: Ankle Brachial Index; Arginine; Blood Pressure; Citrulline; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type III; Placebos; Pulsatile Flow; Vascular Stiffness | 2012 |
Statin treatment decreased serum asymmetric dimethylarginine (ADMA) levels in ischemic stroke patients.
Topics: Aged; Aged, 80 and over; Arginine; Atherosclerosis; Atorvastatin; Brain Ischemia; Cholesterol, LDL; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Linear Models; Male; Middle Aged; Pravastatin; Prospective Studies; Pyrroles; Quinolines; Stroke | 2011 |
Inflammatory-metabolic parameters in obese and nonobese normoandrogenemic polycystic ovary syndrome during metformin and oral contraceptive treatment.
Topics: Adult; Arginine; Body Mass Index; Cardiovascular Diseases; Contraceptives, Oral; Female; Homocysteine; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Obesity; Polycystic Ovary Syndrome; Prospective Studies; Risk Factors; Young Adult | 2011 |
Transient endothelial dysfunction following flow-mediated dilation assessment.
Topics: Adult; Arginine; Biomarkers; Brachial Artery; Endothelium, Vascular; Female; Humans; Hyperemia; Infusions, Intravenous; Italy; Male; Time Factors; Ultrasonography, Doppler; Vasodilation; Young Adult | 2011 |
Helicobacter pylori eradication lowers serum asymmetric dimethylarginine levels.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Amoxicillin; Anti-Bacterial Agents; Arginine; Atherosclerosis; Cardiovascular Abnormalities; Clarithromycin; Enzyme Inhibitors; Female; Helicobacter Infections; Helicobacter pylori; Humans; Lansoprazole; Male; Middle Aged; Nitric Oxide Synthase Type III; Young Adult | 2010 |
Weight loss improves endothelial function independently of ADMA reduction in severe obesity.
Topics: Adolescent; Adult; Aged; Arginine; Body Mass Index; Caloric Restriction; Cell Adhesion Molecules; Endothelial Cells; Female; Humans; Male; Middle Aged; Obesity; Weight Loss; Young Adult | 2011 |
Influence of dietary fat ingestion on asymmetrical dimethylarginine in lean and obese human subjects.
Topics: Adult; Arginine; Chromatography, Gas; Cross-Over Studies; Diet; Dietary Fats; Eating; Energy Intake; Female; Humans; Male; Meals; Nitrates; Nitrites; Obesity; Tandem Mass Spectrometry | 2012 |
Effects of walking on heart rate recovery, endothelium modulators and quality of life in patients with heart failure.
Topics: Aged; Analysis of Variance; Arginine; Biomarkers; Chronic Disease; Endothelium, Vascular; Exercise Therapy; Female; Greece; Heart Failure; Heart Rate; Homocysteine; Humans; Inflammation Mediators; Male; Middle Aged; Oxidative Stress; Quality of Life; Recovery of Function; Surveys and Questionnaires; Time Factors; Treatment Outcome; Walking | 2011 |
Exercise training increases endothelial progenitor cells and decreases asymmetric dimethylarginine in peripheral arterial disease: a randomized controlled trial.
Topics: Aged; Arginine; Cell Movement; Chemokine CXCL12; Endothelial Cells; Exercise; Female; Flow Cytometry; Humans; Intermittent Claudication; Male; Middle Aged; Neovascularization, Pathologic; Peripheral Arterial Disease; Stem Cells; Time Factors; Vascular Endothelial Growth Factor A | 2011 |
Serum retinol-binding protein 4, leptin, and plasma asymmetric dimethylarginine levels in obese and nonobese young women with polycystic ovary syndrome.
Topics: Adult; Arginine; Biomarkers; Female; Humans; Leptin; Obesity; Polycystic Ovary Syndrome; Prospective Studies; Retinol-Binding Proteins, Plasma; Young Adult | 2011 |
The impact of pioglitazone on ADMA and oxidative stress markers in patients with type 2 diabetes.
Topics: Academic Medical Centers; Arginine; Biomarkers; Cross-Over Studies; Diabetes Mellitus, Type 2; Dinoprost; F2-Isoprostanes; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Nitrates; Nitrites; Oxidative Stress; Pioglitazone; Prospective Studies; South Carolina; Thiazolidinediones; Time Factors; Treatment Outcome | 2012 |
Salt sensitivity in blacks: evidence that the initial pressor effect of NaCl involves inhibition of vasodilatation by asymmetrical dimethylarginine.
Topics: Adult; Arginine; Black or African American; Blood Pressure; Dose-Response Relationship, Drug; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Sodium Chloride, Dietary; Time Factors; Vascular Resistance; Vasodilation | 2011 |
Effects of 7 days of arginine-alpha-ketoglutarate supplementation on blood flow, plasma L-arginine, nitric oxide metabolites, and asymmetric dimethyl arginine after resistance exercise.
Topics: Adolescent; Adult; Arginine; Blood Pressure; Dietary Supplements; Double-Blind Method; Heart Rate; Hemodynamics; Humans; Ketoglutaric Acids; Male; Nitrates; Nitric Oxide; Nitrites; Resistance Training; Young Adult | 2011 |
Renovascular protective effects of erythropoietin in patients with chronic kidney disease.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acute Kidney Injury; Aged; Arginine; Atherosclerosis; Biomarkers; Cardiovascular System; Carotid Intima-Media Thickness; Deoxyguanosine; Dose-Response Relationship, Drug; Erythropoietin; Fatty Acid-Binding Proteins; Female; Glomerular Filtration Rate; Hemoglobins; Humans; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Natriuretic Peptide, Brain; Oxidative Stress; Prospective Studies; Recombinant Proteins; Treatment Outcome | 2011 |
Postprandial hyperglycemia impairs vascular endothelial function in healthy men by inducing lipid peroxidation and increasing asymmetric dimethylarginine:arginine.
Topics: Adolescent; Adult; Area Under Curve; Arginine; Blood Glucose; Chromatography, High Pressure Liquid; Cross-Over Studies; Endothelium, Vascular; Homeostasis; Humans; Hyperglycemia; Insulin; Lipid Peroxidation; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Postprandial Period; Young Adult | 2011 |
Addition of liraglutide in patients with Type 2 diabetes well controlled on metformin monotherapy improves several markers of vascular function.
Topics: Adult; Aged; Arginine; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; E-Selectin; Endothelium, Vascular; Female; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Liraglutide; Male; Metformin; Microcirculation; Middle Aged; Plasminogen Activator Inhibitor 1; Proinsulin; Prospective Studies | 2012 |
Sesame oil consumption exerts a beneficial effect on endothelial function in hypertensive men.
Topics: Adult; Analysis of Variance; Arginine; Biomarkers; Blood Pressure; Brachial Artery; Diet; Endothelium, Vascular; Greece; Humans; Hypertension; Inflammation Mediators; Intercellular Adhesion Molecule-1; Male; Middle Aged; Postprandial Period; Sesame Oil; Time Factors; Treatment Outcome; Ultrasonography; Vasodilation | 2013 |
Vascular effects of nebivolol added to hydrochlorothiazide in African Americans with hypertension and echocardiographic evidence of diastolic dysfunction: the NASAA study.
Topics: Adult; Aged; Antihypertensive Agents; Arginine; Benzopyrans; Black or African American; Dose-Response Relationship, Drug; Drug Therapy, Combination; Echocardiography; Ethanolamines; Female; Heart Failure, Diastolic; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Nebivolol; Nitrates; Nitric Oxide; Nitrites | 2012 |
Effect of nisoldipine and olmesartan on endothelium-dependent vasodilation in essential hypertensive patients.
Topics: Aged; Anthracenes; Antihypertensive Agents; Arginine; Blood Pressure; C-Reactive Protein; Case-Control Studies; Endothelin-1; Endothelium; Female; Humans; Hypertension; Imidazoles; Male; Middle Aged; Nisoldipine; Nitric Oxide; Propane; Prostaglandins F; Single-Blind Method; Tetrazoles; Vasodilation | 2012 |
The effect of diet and exercise on markers of endothelial function in overweight and obese women with polycystic ovary syndrome.
Topics: Adult; Arginine; Body Mass Index; Cardiovascular Diseases; Diet; Endothelium, Vascular; Exercise; Exercise Therapy; Female; Humans; Insulin Resistance; Intercellular Adhesion Molecule-1; Overweight; Plasminogen Activator Inhibitor 1; Polycystic Ovary Syndrome; Risk; Vascular Cell Adhesion Molecule-1 | 2012 |
Ramipril sensitizes platelets to nitric oxide: implications for therapy in high-risk patients.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Arginine; Biomarkers; Blood Platelets; Cohort Studies; Cyclic GMP; Double-Blind Method; Drug Administration Schedule; Female; Guanylate Cyclase; Humans; Male; Malondialdehyde; Middle Aged; Nitric Oxide; Nitroprusside; Oxidative Stress; Platelet Aggregation; Ramipril; Thrombospondin 1 | 2012 |
Probing the mechanisms of intradialytic hypertension: a pilot study targeting endothelial cell dysfunction.
Topics: AC133 Antigen; Adult; Aged; Aldehyde Dehydrogenase; Antigens, CD; Antigens, CD34; Antihypertensive Agents; Arginine; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Body Weight; Carbazoles; Carvedilol; Endothelin-1; Endothelium, Vascular; Female; Glycoproteins; Humans; Hypertension; Male; Middle Aged; Peptides; Pilot Projects; Propanolamines; Prospective Studies; Renal Dialysis; Stem Cells; Texas; Time Factors; Treatment Outcome; Vascular Stiffness; Vasodilation; Vasodilator Agents | 2012 |
Supplementation of a γ-tocopherol-rich mixture of tocopherols in healthy men protects against vascular endothelial dysfunction induced by postprandial hyperglycemia.
Topics: Adolescent; Adult; Antioxidants; Arginine; Ascorbic Acid; Blood Glucose; Brachial Artery; Dietary Supplements; Endothelium, Vascular; gamma-Tocopherol; Humans; Hyperglycemia; Insulin; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Tocopherols; Uric Acid; Young Adult | 2013 |
Feasibility of landiolol and bisoprolol for prevention of atrial fibrillation after coronary artery bypass grafting: a pilot study.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Antioxidants; Arginine; Atrial Fibrillation; Biomarkers; Bisoprolol; C-Reactive Protein; Coronary Artery Bypass; Creatine Kinase, MB Form; Drug Administration Schedule; Fatty Acid Binding Protein 3; Fatty Acid-Binding Proteins; Female; Hemodynamics; Humans; Infusions, Intravenous; Japan; Male; Middle Aged; Morpholines; Natriuretic Peptide, Brain; Pilot Projects; Serum Amyloid P-Component; Single-Blind Method; Time Factors; Treatment Outcome; Troponin I; Urea | 2012 |
Blood pressure and plasma renin activity responses to different strategies to inhibit the renin-angiotensin-aldosterone system during exercise.
Topics: Adult; Aged; Amides; Arginine; Blood Pressure; Demography; Endpoint Determination; Exercise; Female; Fumarates; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Renin; Renin-Angiotensin System; Systole; Tetrazoles; Valine; Valsartan | 2013 |
Serum levels of asymmetric dimethylarginine and apelin as potential markers of vascular endothelial dysfunction in early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Apelin; Arginine; Arthritis, Rheumatoid; Endothelium, Vascular; Female; Humans; Intercellular Signaling Peptides and Proteins; Male; Middle Aged | 2012 |
Improved blood pressure, nitric oxide and asymmetric dimethylarginine are independent after bariatric surgery.
Topics: Arginine; Bariatric Surgery; Blood Pressure; Female; Humans; Male; Nitric Oxide; Obesity, Morbid; Weight Loss | 2012 |
[Regular exercise training decreases asymmetric dimethylarginine after kidney transplantation].
Topics: Adiponectin; Adult; Aged; Arginine; C-Reactive Protein; Exercise Therapy; Female; Humans; Kidney Transplantation; Male; Middle Aged; Nitric Oxide Synthase; Tumor Necrosis Factor-alpha | 2012 |
Oral L-arginine supplementation in patients with mild arterial hypertension and its effect on plasma level of asymmetric dimethylarginine, L-citruline, L-arginine and antioxidant status.
Topics: Administration, Oral; Adult; Antioxidants; Arginine; Blood Pressure Monitoring, Ambulatory; Citrulline; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypertension; Male | 2012 |
The biological evaluation of ADMA/SDMA and eNOS in patients with ACHF.
Topics: Adult; Aged; Alanine Transaminase; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Arginine; Aspartate Aminotransferases; Blotting, Western; Chromatography, High Pressure Liquid; Digoxin; Diuretics; Echocardiography; Electron Transport Complex IV; Female; Heart Failure; Humans; Kidney Function Tests; Leukocytes, Mononuclear; Male; Middle Aged; Nitric Oxide Synthase Type III; Oxygen | 2013 |
Organic nitrates favor regression of left ventricular hypertrophy in hypertensive patients on chronic peritoneal dialysis.
Topics: Adult; Aged; Antihypertensive Agents; Arginine; Blood Pressure; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Isosorbide Dinitrate; Kidney Failure, Chronic; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Prospective Studies; Time Factors; Treatment Outcome; Vasodilator Agents | 2013 |
[Impact of adding folic acid, vitamin B(12) and probucol to standard antihypertensive medication on plasma homocysteine and asymmetric dimethylarginine levels of essential hypertension patients].
Topics: Aged; Antihypertensive Agents; Arginine; Female; Folic Acid; Homocysteine; Humans; Hypertension; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type III; Plasma; Probucol; Vitamin B 12; Vitamin B Complex; Vitamins | 2012 |
Hypothermia decreases cerebrospinal fluid asymmetric dimethylarginine levels in children with traumatic brain injury.
Topics: Adolescent; Arginine; Brain Injuries; Case-Control Studies; Cerebrospinal Fluid; Child; Child, Preschool; Chromatography, Liquid; Female; Humans; Hypothermia, Induced; Infant; Male; Nitrates; Nitrites; Tandem Mass Spectrometry | 2013 |
Aspirin increases nitric oxide formation in chronic stable coronary disease.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Aspirin; Biomarkers; Cardiovascular Agents; Coronary Disease; Dose-Response Relationship, Drug; Double-Blind Method; Down-Regulation; Female; Heme Oxygenase-1; Humans; Male; Middle Aged; Nitric Oxide; Platelet Aggregation Inhibitors; Tablets, Enteric-Coated; Up-Regulation | 2013 |
The association between progression of atherosclerosis and the methylated amino acids asymmetric dimethylarginine and trimethyllysine.
Topics: Adenosine; Aged; Arginine; Coronary Angiography; Coronary Artery Disease; Disease Progression; Ethionine; Female; Folic Acid; Follow-Up Studies; Humans; Lysine; Male; Methylation; Middle Aged; Treatment Outcome; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2013 |
Pioglitazone decreases asymmetric dimethylarginine levels in patients with impaired glucose tolerance or type 2 diabetes.
Topics: Aged; Aged, 80 and over; Arginine; Diabetes Mellitus, Type 2; Female; Fibronectins; Glucose Intolerance; Humans; Male; Middle Aged; Pioglitazone; Regression Analysis; Sulfonylurea Compounds; Thiazolidinediones | 2013 |
Asymmetric dimethylarginine in response to recombinant tissue-type plasminogen activator and erythropoietin in acute stroke.
Topics: Acute Disease; Aged; Aged, 80 and over; Arginine; Double-Blind Method; Drug Therapy, Combination; Erythropoietin; Female; Humans; Male; Middle Aged; Severity of Illness Index; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome | 2013 |
Lifestyle modification decreases arterial stiffness and plasma asymmetric dimethylarginine level in overweight and obese men.
Topics: Adult; Animals; Ankle Brachial Index; Arginine; Biomarkers; Caloric Restriction; Cardiovascular Diseases; Down-Regulation; Exercise; Humans; Male; Middle Aged; Obesity; Overweight; Pulse Wave Analysis; Risk Reduction Behavior; Time Factors; Treatment Outcome; Vascular Stiffness | 2013 |
Serum uric acid levels and endothelial dysfunction in patients with autosomal dominant polycystic kidney disease.
Topics: Adult; Arginine; C-Reactive Protein; Cross-Sectional Studies; Endothelium, Vascular; Glomerular Filtration Rate; Humans; Middle Aged; Multivariate Analysis; Polycystic Kidney, Autosomal Dominant; Uric Acid; Vasodilation | 2013 |
Low-fat milk ingestion prevents postprandial hyperglycemia-mediated impairments in vascular endothelial function in obese individuals with metabolic syndrome.
Topics: Adult; Animals; Area Under Curve; Arginine; Blood Glucose; Brachial Artery; Cross-Over Studies; Diet; Dietary Fats; Double-Blind Method; Endothelium, Vascular; Fasting; Female; Humans; Hyperglycemia; Lipid Peroxidation; Male; Malondialdehyde; Metabolic Syndrome; Milk; Nitric Oxide; Obesity; Oryza; Oxidative Stress; Plant Preparations; Postprandial Period; Vascular Diseases; Vasodilation | 2013 |
Disparate effects of anti-TNF-α therapies on measures of disease activity and mediators of endothelial damage in ankylosing spondylitis.
Topics: Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arginine; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Etanercept; Female; Humans; Immunoglobulin G; Male; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha | 2013 |
Comparision of effects of rosuvastatin versus atorvastatin treatment on plasma levels of asymmetric dimethylarginine in patients with hyperlipidemia having coronary artery disease.
Topics: Arginine; Atorvastatin; Biomarkers; Coronary Angiography; Coronary Stenosis; Down-Regulation; Female; Fluorobenzenes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Lipids; Male; Middle Aged; Prospective Studies; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Severity of Illness Index; Sulfonamides; Time Factors; Treatment Outcome; Turkey | 2014 |
Aerobic exercise training decreases plasma asymmetric dimethylarginine concentrations with increase in arterial compliance in postmenopausal women.
Topics: Aged; Arginine; Biomarkers; Carotid Arteries; Carotid Intima-Media Thickness; Compliance; Down-Regulation; Exercise; Female; Heart Rate; Humans; Japan; Middle Aged; Postmenopause; Time Factors; Vascular Stiffness | 2014 |
Effect of vildagliptin add-on treatment to metformin on plasma asymmetric dimethylarginine in type 2 diabetes mellitus patients.
Topics: Adamantane; Adult; Aged; Arginine; C-Reactive Protein; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Combinations; Female; Fibrinogen; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Nitric Oxide; Nitriles; Pyrrolidines; Vildagliptin | 2014 |
Nutrition before, during, and after surgery increases the arginine:asymmetric dimethylarginine ratio and relates to improved myocardial glucose metabolism: a randomized controlled trial.
Topics: Aged; Algorithms; Arginine; Coronary Artery Bypass, Off-Pump; Enteral Nutrition; Fluorodeoxyglucose F18; Glucose; Heart; Humans; Male; Middle Aged; Myocardium; Netherlands; Nutritional Status; Parenteral Nutrition; Perioperative Care; Positron-Emission Tomography; Postoperative Care; Postoperative Complications; Preoperative Care; Risk | 2014 |
Supplementation of folic acid and vitamin B₁₂ reduces plasma levels of asymmetric dimethylarginine in patients with acute ischemic stroke.
Topics: Aged; Arginine; Blood Chemical Analysis; Brain Ischemia; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Stroke; Time Factors; Treatment Outcome; Vitamin B 12 | 2014 |
Effect of high potassium diet on endothelial function.
Topics: Adolescent; Adult; Aged; Arginine; Blood Glucose; Blood Pressure; Body Mass Index; Cross-Over Studies; E-Selectin; Endothelin-1; Endothelium, Vascular; Female; Fruit; Healthy Volunteers; Humans; Intercellular Adhesion Molecule-1; Male; Middle Aged; Patient Compliance; Potassium, Dietary; Pulse Wave Analysis; Single-Blind Method; Urinalysis; Vegetables; Young Adult | 2014 |
Asymmetric dimethylarginine and L-arginine levels in neonatal sepsis and septic shock.
Topics: Arginine; Biomarkers; Case-Control Studies; Female; Humans; Infant, Newborn; Male; Multiple Organ Failure; Prognosis; Prospective Studies; Sepsis; Severity of Illness Index; Shock, Septic | 2015 |
The importance of intraoperative selenium blood levels on organ dysfunction in patients undergoing off-pump cardiac surgery: a randomised controlled trial.
Topics: Aged; Arginine; Biomarkers; Coronary Artery Bypass, Off-Pump; Creatine Kinase, MB Form; Female; Glutathione Peroxidase; Humans; Interleukin-6; Male; Middle Aged; Oxidative Stress; Postoperative Complications; Postoperative Period; Predictive Value of Tests; Selenium | 2014 |
Decreased levels of homoarginine and asymmetric dimethylarginine in children with type 1 diabetes: associations with cardiovascular risk factors but no effect by atorvastin.
Topics: Adolescent; Anticholesteremic Agents; Arginine; Atorvastatin; Cardiovascular Diseases; Diabetes Mellitus, Type 1; Female; Follow-Up Studies; Glycated Hemoglobin; Heptanoic Acids; Homoarginine; Humans; Lipids; Male; Pilot Projects; Pyrroles; Risk Factors; Treatment Outcome | 2015 |
Effects of an energy-restricted diet rich in plant-derived α-linolenic acid on systemic inflammation and endothelial function in overweight-to-obese patients with metabolic syndrome traits.
Topics: Adipokines; Adult; alpha-Linolenic Acid; Arginine; Biomarkers; C-Reactive Protein; Chitinase-3-Like Protein 1; Diet, Reducing; Down-Regulation; E-Selectin; Endothelium, Vascular; Fatty Acids, Monounsaturated; Female; Humans; Inflammation Mediators; Intercellular Adhesion Molecule-1; Lectins; Male; Metabolic Syndrome; Middle Aged; Obesity; Overweight; Plant Oils; Rapeseed Oil; Vasculitis; Weight Loss | 2014 |
Decrease of asymmetric dimethyl arginine after anti-TNF therapy in patients with rheumatoid arthritis.
Topics: Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arginine; Arthritis, Rheumatoid; Etanercept; Female; Humans; Immunoglobulin G; Male; Middle Aged; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2014 |
The impact of different supervised exercise regimens on endothelial function in patients with intermittent claudication.
Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Endothelium, Vascular; Exercise Test; Exercise Therapy; Exercise Tolerance; Female; Humans; Hyperemia; Intermittent Claudication; Male; Middle Aged; Nitric Oxide; Pain Measurement; Quality of Life; Resistance Training; South Australia; Surveys and Questionnaires; Time Factors; Treatment Outcome; Vasodilation; Walking | 2015 |
Digital plethysmography and arginine metabolism in prehypertension: effect of nebivolol therapy.
Topics: Adult; Antihypertensive Agents; Arginine; Benzopyrans; Blood Pressure; Citrulline; Endothelium, Vascular; Ethanolamines; Female; Humans; Male; Middle Aged; Nebivolol; Nitric Oxide; Plethysmography; Prehypertension; Prospective Studies; Regional Blood Flow | 2015 |
Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease.
Topics: Aged; Arginine; Arthritis, Rheumatoid; Coronary Artery Disease; Female; Homoarginine; Homocysteine; Humans; Male; Middle Aged; Peripheral Arterial Disease | 2015 |
[Salvia Miltiorrhiza reduces plasma levels of asymmetric ADMA in patients with non-ST elevation myocardial infarction undergoing percutaneous coronary intervention].
Topics: Arginine; Drugs, Chinese Herbal; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Salvia miltiorrhiza | 2014 |
Effects of dialysis solution on the cardiovascular function in peritoneal dialysis patients.
Topics: Adult; Aged; Arginine; Biomarkers; Blood Flow Velocity; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Carotid Artery Diseases; Carotid Intima-Media Thickness; Causality; Comorbidity; Dialysis Solutions; Echocardiography; Female; Humans; Hydrogen-Ion Concentration; Incidence; Male; Middle Aged; Peritoneal Dialysis; Prospective Studies; Renal Insufficiency | 2015 |
Comparison of Before and After Varicocelectomy Levels of Trace Elements, Nitric Oxide, Asymmetric Dimethylarginine and Malondialdehyde in the Seminal Plasma and Peripheral and Spermatic Veins.
Topics: Adult; Arginine; Humans; Male; Malondialdehyde; Nitric Oxide; Postoperative Period; Preoperative Period; Semen; Trace Elements; Varicocele | 2015 |
Proton pump inhibitors and vascular function: A prospective cross-over pilot study.
Topics: Administration, Oral; Adult; Arginine; Biomarkers; California; Coronary Disease; Cross-Over Studies; Drug Administration Schedule; Female; Humans; Lansoprazole; Male; Middle Aged; Pilot Projects; Predictive Value of Tests; Prospective Studies; Proton Pump Inhibitors; Reproducibility of Results; Risk Assessment; Time Factors; Upper Extremity; Vasodilation; Young Adult | 2015 |
Differential associations of circulating asymmetric dimethylarginine and cell adhesion molecules with metformin use in patients with type 2 diabetes mellitus and stable coronary artery disease.
Topics: Aged; Aged, 80 and over; Arginine; Cell Adhesion Molecules; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; Male; Metformin; Middle Aged; Time Factors | 2015 |
Asymmetric dimethylarginine (ADMA) in human blood: effects of extended haemodialysis in the critically ill patient with acute kidney injury, protein binding to human serum albumin and proteolysis by thermolysin.
Topics: Acute Kidney Injury; Arginine; Critical Illness; Female; Humans; Male; Protein Binding; Proteolysis; Renal Dialysis; Serum Albumin; Thermolysin | 2015 |
Changes in plasma levels of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine after a single dose of vardenafil in patients with pulmonary hypertension.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Arginine; Atrial Function, Right; Atrial Pressure; Biomarkers; Cardiac Output; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Phosphodiesterase 5 Inhibitors; Time Factors; Treatment Outcome; Vardenafil Dihydrochloride; Vasodilator Agents | 2015 |
Impact of Indoxyl Sulfate, a Uremic Toxin, on Non-Culprit Coronary Plaque Composition Assessed on Integrated Backscatter Intravascular Ultrasound.
Topics: Aged; Arginine; Biomarkers; Coronary Artery Disease; Female; Humans; Indican; Male; Middle Aged; Plaque, Atherosclerotic; Risk Factors; Ultrasonography, Interventional | 2015 |
Chronic heart failure and aging - effects of exercise training on endothelial function and mechanisms of endothelial regeneration: Results from the Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study.
Topics: Aged; Aging; Arginine; Blood Flow Velocity; Cell Count; Chemokine CXCL12; Endothelial Progenitor Cells; Endothelium, Vascular; Exercise Therapy; Heart Failure; Humans; Intercellular Adhesion Molecule-1; Middle Aged; Prospective Studies; Radial Artery; Regeneration; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor A | 2016 |
Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free L-arginine in humans.
Topics: Adolescent; Adult; Amidinotransferases; Amino Acid Metabolism, Inborn Errors; Animals; Arginine; Child; Coronary Artery Disease; Developmental Disabilities; Female; Guanidinoacetate N-Methyltransferase; Homoarginine; Humans; Intellectual Disability; Language Development Disorders; Male; Mice; Mice, Knockout; Middle Aged; Movement Disorders; Peripheral Arterial Disease; Speech Disorders | 2015 |
Serum and cerebrospinal fluid concentrations of homoarginine, arginine, asymmetric and symmetric dimethylarginine, nitrite and nitrate in patients with multiple sclerosis and neuromyelitis optica.
Topics: Adult; Arginine; Female; Homoarginine; Humans; Male; Middle Aged; Multiple Sclerosis; Neuromyelitis Optica; Nitrates; Nitrites | 2015 |
The L-arginine/NO pathway and homoarginine are altered in Duchenne muscular dystrophy and improved by glucocorticoids.
Topics: Adolescent; Adult; Arginine; Child; Child, Preschool; Cross-Sectional Studies; Glucocorticoids; Homoarginine; Humans; Infant; Male; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Nitric Oxide; Pilot Projects | 2015 |
Plasma ADMA associates with all-cause mortality in renal transplant recipients.
Topics: Adult; Aged; Arginine; Disease-Free Survival; Endothelium, Vascular; Female; Follow-Up Studies; Graft Rejection; Humans; Kidney Transplantation; Male; Middle Aged; Models, Biological; Survival Rate | 2015 |
Homocysteine and Arginine-to-Asymmetric Dimethylarginine Ratio Associated With Blood Pressure Abnormalities in Children With Early Chronic Kidney Disease.
Topics: Adolescent; Arginine; Blood Pressure; Child; Cross-Sectional Studies; Female; Homocysteine; Humans; Hypertension; Male; Renal Insufficiency, Chronic; Vascular Stiffness | 2015 |
Homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in short stature children without and with growth hormone deficiency: hArg and ADMA are involved differently in growth in the childhood.
Topics: Adolescent; Adult; Arginine; Child; Female; Growth Disorders; Homoarginine; Human Growth Hormone; Humans; Insulin-Like Growth Factor I; Male | 2015 |
Interrelationship of Multiple Endothelial Dysfunction Biomarkers with Chronic Kidney Disease.
Topics: Adult; Aged; Albuminuria; Arginine; Biomarkers; Blood Glucose; Cell Adhesion Molecules; Comorbidity; Creatinine; Diabetes Mellitus; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Hypertension; Inflammation; Kidney Function Tests; Lipids; Male; Middle Aged; Nitric Oxide; Renal Insufficiency, Chronic; Risk; Sensitivity and Specificity; Thrombophilia; Vasodilation; von Willebrand Factor; Young Adult | 2015 |
Asymmetric and Symmetric Dimethylarginine and Sympathetic Nerve Traffic after Renal Denervation in Patients with Resistant Hypertension.
Topics: Aged; Arginine; Blood Pressure; Drug Resistance; Female; Heart Rate; Humans; Hypertension; Longitudinal Studies; Male; Middle Aged; Muscle, Skeletal; Sympathectomy; Sympathetic Nervous System | 2015 |
Reduction in asymmetric dimethylarginine plasma levels by coenzyme Q10 supplementation in patients with type 2 diabetes mellitus.
Topics: Adult; Aged; Antioxidants; Arginine; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Supplements; Double-Blind Method; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Ubiquinone | 2015 |
Angiotensin converting enzyme inhibition increases ADMA concentration in patients on maintenance hemodialysis--a randomized cross-over study.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Arginine; Bradykinin; Cell Line; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Ramipril; Renal Dialysis; Valsartan | 2015 |
Microvascular effects of the inhibition of dipeptidylpeptidase IV by linagliptin in nondiabetic hypertensive patients.
Topics: Aged; Arginine; Arterial Pressure; C-Reactive Protein; Cyclic GMP; Cystatin C; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Female; Glycated Hemoglobin; Humans; Hypertension; Linagliptin; Male; Microvessels; Middle Aged; Regional Blood Flow; Retinal Vessels; Transforming Growth Factor beta1 | 2016 |
Association of Serum Asymmetric Dimethylarginine With Muscle Strength and Gait Speed: A Cross-Sectional Study of the HEIJO-KYO Cohort.
Topics: Aged; Aged, 80 and over; Arginine; Cohort Studies; Cross-Sectional Studies; Female; Gait; Hand Strength; Humans; Male; Middle Aged; Quadriceps Muscle | 2016 |
Asymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase.
Topics: Aged; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Activation; Female; Humans; Male; Mice; Nitric Oxide; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Signal Transduction; Simvastatin | 2016 |
Effect of the transdermal low-level laser therapy on endothelial function.
Topics: Adult; Angiostatins; Arginine; Female; Fibroblast Growth Factors; Glutathione; Humans; Lasers, Semiconductor; Low-Level Light Therapy; Male; Nitric Oxide; Vascular Endothelial Growth Factor A | 2016 |
Effect of trelagliptin on vascular endothelial functions and serum adiponectin level in patients with type 2 diabetes: a preliminary single-arm prospective pilot study.
Topics: Adiponectin; Adult; Aged; Arginine; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Endothelium, Vascular; Female; Glycated Hemoglobin; Humans; Japan; Male; Middle Aged; Pilot Projects; Prospective Studies; Time Factors; Treatment Outcome; Up-Regulation; Uracil; Vasodilation | 2016 |
Effects of Vitamin D3 on asymmetric- and symmetric dimethylarginine in arterial hypertension.
Topics: Aged; Analysis of Variance; Arginine; Blood Pressure; Cholecalciferol; Dietary Supplements; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Vitamin D; Vitamin D Deficiency | 2018 |
Serum Asymmetric and Symmetric Dimethylarginine and Morbidity and Mortality in Hemodialysis Patients.
Topics: Arginine; Cardiovascular Diseases; Female; Humans; Male; Middle Aged; Morbidity; Prospective Studies; Renal Dialysis | 2017 |
Genetic variations in the alanine-glyoxylate aminotransferase 2 (AGXT2) gene and dimethylarginines levels in rheumatoid arthritis.
Topics: Aged; Arginine; Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Transaminases | 2017 |
Effect of Febuxostat on the Endothelial Dysfunction in Hemodialysis Patients: A Randomized, Placebo-Controlled, Double-Blinded Study.
Topics: Administration, Oral; Adult; Alanine Transaminase; Arginine; Aspartate Aminotransferases; C-Reactive Protein; Cardiovascular Diseases; Double-Blind Method; Endothelium, Vascular; Enzyme Inhibitors; Febuxostat; Female; Humans; Incidence; Kidney Failure, Chronic; Male; Middle Aged; Pancytopenia; Placebos; Prospective Studies; Renal Dialysis; Risk Factors; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2017 |
Does Vitamin D Status Correlate with Cardiometabolic Risk Factors in Adults with Growth Hormone Deficiency?
Topics: 25-Hydroxyvitamin D 2; Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Blood Glucose; C-Reactive Protein; Female; Human Growth Hormone; Humans; Insulin; Male; Metabolic Syndrome; Middle Aged; Uric Acid | 2017 |
Improvement in asymmetric dimethylarginine and oxidative stress in patients with limb salvage after autologous mononuclear stem cell application for critical limb ischemia.
Topics: Aged; Arginine; Autografts; Extremities; Female; Follow-Up Studies; Humans; Ischemia; Leukocytes, Mononuclear; Male; Middle Aged; Oxidative Stress; Stem Cell Transplantation; Stem Cells | 2017 |
Dietary Plant Sterols Supplementation Increases In Vivo Nitrite and Nitrate Production in Healthy Adults: A Randomized, Controlled Study.
Topics: Adult; Arginine; Cholesterol; Cross-Over Studies; Dietary Supplements; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Nitrates; Nitrites; Phytosterols; Young Adult | 2017 |
Impact of Asymmetric Dimethylarginine on Coronary Physiology Early After Heart Transplantation.
Topics: Arginine; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Follow-Up Studies; Fractional Flow Reserve, Myocardial; Heart Transplantation; Humans; Male; Microcirculation; Middle Aged; Prognosis; Prospective Studies; Time Factors; Vascular Resistance | 2017 |
Associations of Plasma Nitrite, L-Arginine and Asymmetric Dimethylarginine With Morbidity and Mortality in Patients With Necrotizing Soft Tissue Infections.
Topics: Adult; Aged; Arginine; Biomarkers; Disease-Free Survival; Female; Hospital Mortality; Humans; Male; Middle Aged; Nitrites; Prospective Studies; Severity of Illness Index; Shock, Septic; Soft Tissue Infections; Survival Rate; Time Factors | 2018 |
Vitamin D and methylarginines in chronic kidney disease (CKD).
Topics: Aged; Arginine; Calcium; Cross-Sectional Studies; Double-Blind Method; Ergocalciferols; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Parathyroid Hormone; Placebos; Vitamin D | 2017 |
Effect of statin on arginine metabolites in treated HIV-infection.
Topics: Adult; Anti-HIV Agents; Arginine; Biomarkers; Carotid Artery Diseases; Carotid Intima-Media Thickness; Chi-Square Distribution; Cholesterol, LDL; Double-Blind Method; Female; HIV Infections; HIV-1; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Linear Models; Male; Middle Aged; Ohio; Risk Factors; RNA, Viral; Rosuvastatin Calcium; Time Factors; Treatment Outcome; Viral Load | 2017 |
Renin-angiotensin system blockade promotes a cardio-renal protection in albuminuric homozygous sickle cell patients.
Topics: Adult; Albuminuria; Anemia, Sickle Cell; Angiotensin-Converting Enzyme Inhibitors; Arginine; Biomarkers; Blood Pressure; Creatinine; Female; Glomerular Filtration Rate; Humans; Male; Pulse Wave Analysis; Renin-Angiotensin System; Tricuspid Valve Insufficiency | 2017 |
How does spa treatment affect cardiovascular function and vascular endothelium in patients with generalized osteoarthritis? A pilot study through plasma asymmetric di-methyl arginine (ADMA) and L-arginine/ADMA ratio.
Topics: Aged; Arginine; Balneology; Blood Pressure; Endothelium, Vascular; Female; Heart Rate; Humans; Male; Middle Aged; Osteoarthritis; Pilot Projects | 2018 |
Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction.
Topics: Aged; Arginine; Biomarkers; Exercise Therapy; Female; Follow-Up Studies; Heart Failure; Humans; Male; Middle Aged; Nitric Oxide; Prospective Studies; Signal Transduction; Stroke Volume | 2018 |
Hemodiafiltration is associated with reduced inflammation, oxidative stress and improved endothelial risk profile compared to high-flux hemodialysis in children.
Topics: Adolescent; Arginine; Biomarkers; Child; Female; Hemodiafiltration; Humans; Inflammation; Male; Oxidative Stress; Prospective Studies; Treatment Outcome | 2018 |
Asymmetric dimethylarginine and soluble inter-cellular adhesion molecule-1 serum levels alteration following ginger supplementation in patients with type 2 diabetes: a randomized double-blind, placebo-controlled clinical trial.
Topics: Adult; Arginine; Biomarkers; Diabetes Mellitus, Type 2; Dietary Supplements; Double-Blind Method; Female; Humans; Intercellular Adhesion Molecule-1; Male; Middle Aged; Plant Extracts; Zingiber officinale | 2018 |
Asymmetric dimethylarginine serum levels are associated with early mortality after allogeneic stem cell transplantation.
Topics: Allografts; Arginine; Disease-Free Survival; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Risk Factors; Survival Rate | 2019 |
Serum Levels of Protein-Bound Methylglyoxal-Derived Hydroimidazolone-1 are Independently Correlated with Asymmetric Dimethylarginine.
Topics: Aged; Arginine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glucose Intolerance; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Imidazoles; Inflammation; Male; Middle Aged; Protein Binding; Pyruvaldehyde; Vascular Stiffness | 2019 |
The Effect of Vitamin D on Serum Asymmetric Dimethylarginine in Patients with Mild to Moderate Ulcerative Colitis.
Topics: Arginine; Colitis, Ulcerative; Humans; Vitamin D; Vitamins | 2020 |
Effects of Selenium Supplementation on Asymmetric Dimethylarginine and Cardiometabolic Risk Factors in Patients with Polycystic Ovary Syndrome.
Topics: Adolescent; Adult; Arginine; Cardiometabolic Risk Factors; Dietary Supplements; Double-Blind Method; Female; Humans; Middle Aged; Polycystic Ovary Syndrome; Selenium; Testosterone; Young Adult | 2020 |
L-Citrulline increases nitric oxide and improves control in obese asthmatics.
Topics: Adult; Aged; Arginine; Asthma; Citrulline; Dietary Supplements; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Obesity; Oxidative Stress; Pilot Projects; Proof of Concept Study; Severity of Illness Index; Treatment Outcome; Young Adult | 2019 |
Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial.
Topics: Adult; Arginine; Blood Pressure; Carotid Intima-Media Thickness; Diet Therapy; Endothelium, Vascular; Exercise Therapy; Female; Healthy Lifestyle; Humans; Hypertension; Male; Middle Aged; Severity of Illness Index; Treatment Outcome; Vascular Stiffness | 2020 |
The Effect of Corrected Inflammation, Oxidative Stress and Endothelial Dysfunction on Fmd Levels in Patients with Selected Chronic Diseases: A Quasi-Experimental Study.
Topics: Adult; Aged; Antioxidants; Arginine; Atherosclerosis; C-Reactive Protein; Chronic Disease; Dietary Supplements; Endothelium, Vascular; Fatty Acids, Omega-3; Female; Humans; Inflammation; Male; Malondialdehyde; Middle Aged; Morinda; Oxidative Stress; Serum Amyloid P-Component; Vasodilation | 2020 |
ADMA mediates gastric cancer cell migration and invasion via Wnt/β-catenin signaling pathway.
Topics: Adenocarcinoma; Arginine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Invasiveness; Prognosis; Stomach Neoplasms; Wnt Signaling Pathway; Wound Healing | 2021 |
Resistance training improves sleep quality, redox balance and inflammatory profile in maintenance hemodialysis patients: a randomized controlled trial.
Topics: Aged; Arginine; Biomarkers; Endothelium; Humans; Inflammation; Male; Middle Aged; Muscle Strength; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Renal Dialysis; Renal Insufficiency, Chronic; Resistance Training; Sleep; Sleep Wake Disorders; Treatment Outcome | 2020 |
Asymmetric dimethylarginine predicts perioperative cardiovascular complications in patients undergoing medium-to-high risk non-cardiac surgery.
Topics: Arginine; C-Reactive Protein; Citrulline; Humans; Prospective Studies | 2020 |
Randomized, Open-Label, Cross-Over Comparison of the Effects of Benzbromarone and Febuxostat on Endothelial Function in Patients with Hyperuricemia.
Topics: Adiponectin; Aged; Arginine; Benzbromarone; Cross-Over Studies; Endothelium, Vascular; Febuxostat; Female; Gout Suppressants; Humans; Hyperemia; Hyperuricemia; Male; Middle Aged; Organic Anion Transporters; Organic Cation Transport Proteins; Treatment Outcome; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2020 |
A high-protein meal does not improve blood pressure or vasoactive biomarker responses to acute exercise in humans.
Topics: Adult; Arginine; Biomarkers; Blood Pressure; Cross-Over Studies; Dietary Fats; Dietary Proteins; Double-Blind Method; Exercise; Female; Humans; Male; Meals; Postprandial Period | 2020 |
Combination Treatment with Sodium Nitrite and Isoquercetin on Endothelial Dysfunction among Patients with CKD: A Randomized Phase 2 Pilot Trial.
Topics: Aged; Amine Oxidase (Copper-Containing); Antioxidants; Arginine; Biomarkers; Cell Adhesion Molecules; Drug Therapy, Combination; E-Selectin; Endostatins; Endothelium; Female; Glomerular Filtration Rate; Humans; Inflammation; Intercellular Adhesion Molecule-1; Male; Medication Adherence; Middle Aged; Oxidative Stress; Pilot Projects; Quercetin; Renal Insufficiency, Chronic; Sodium Nitrite; Vasodilation; von Willebrand Factor | 2020 |
Role of endothelial function determined by asymmetric dimethylarginine in the prediction of resistant hypertension: A subanalysis of ReHOT trial.
Topics: Antihypertensive Agents; Arginine; Blood Pressure; Humans; Hypertension | 2020 |
Effects of virgin coconut oil consumption on metabolic syndrome components and asymmetric dimethylarginine: A randomized controlled clinical trial.
Topics: Adult; Arginine; Biomarkers; Blood Glucose; Coconut Oil; Dietary Fats; Female; Humans; Iran; Lipids; Male; Metabolic Syndrome; Middle Aged; Time Factors; Young Adult | 2021 |
Whole-Body Cryotherapy Increases the Activity of Nitric Oxide Synthase in Older Men.
Topics: Aged; Arginine; Athletes; Body Mass Index; Cryotherapy; Exercise; Humans; Interleukins; Male; Middle Aged; Nitric Oxide Synthase Type II; Oxidative Stress; Physical Endurance; Tyrosine | 2021 |
Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial.
Topics: Adult; Aged; Arginine; Atherosclerosis; Biomarkers; Brachial Artery; Dilatation, Pathologic; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Japan; Male; Mandible; Maxilla; Middle Aged; Oral Hygiene; Periodontal Diseases; Self Care; Treatment Outcome; Young Adult | 2021 |
Effects of treatment with SGLT-2 inhibitors on arginine-related cardiovascular and renal biomarkers.
Topics: Arginine; Benzhydryl Compounds; Biomarkers; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucosides; Glycated Hemoglobin; Humans; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Sodium-Glucose Transporter 2 Inhibitors; Time Factors; Treatment Outcome | 2022 |
The impact of probiotic yogurt versus ordinary yogurt on serum sTWEAK, sCD163, ADMA, LCAT and BUN in patients with chronic heart failure: a randomized, triple-blind, controlled trial.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Arginine; Blood Urea Nitrogen; Cytokine TWEAK; Heart Failure; Humans; Phosphatidylcholine-Sterol O-Acyltransferase; Probiotics; Receptors, Cell Surface; Tumor Necrosis Factor-alpha; Yogurt | 2022 |
Vitamin D Supplementation Influences Ultramarathon-Induced Changes in Serum Amino Acid Levels, Tryptophan/Branched-Chain Amino Acid Ratio, and Arginine/Asymmetric Dimethylarginine Ratio.
Topics: Amino Acids; Amino Acids, Branched-Chain; Arginine; Dietary Supplements; Humans; Male; Tryptophan; Vitamin D; Vitamins | 2023 |
1651 other study(ies) available for n,n-dimethylarginine and arginine
Article | Year |
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Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia.
Topics: Amidohydrolases; Amino Acid Sequence; Animals; Binding Sites; Cloning, Molecular; Cysteine; Dose-Response Relationship, Drug; Drug Design; Homocysteine; Humans; Hydrogen Peroxide; Hyperhomocysteinemia; Kinetics; Molecular Sequence Data; Oxidation-Reduction; Sequence Homology, Amino Acid; Substrate Specificity | 2007 |
Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis.
Topics: Amino Acid Oxidoreductases; Arginine; Chromatography, High Pressure Liquid; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Nitric Oxide; Nitric Oxide Synthase | 1992 |
Methylations of 70,000-Da heat shock proteins in 3T3 cells: alterations by arsenite treatment, by different stages of growth and by virus transformation.
Topics: 3T3 Cells; Animals; Arginine; Arsenic; Arsenites; Avian Sarcoma Viruses; Cell Division; Cell Transformation, Viral; Chromatography, Ion Exchange; Electrophoresis, Gel, Two-Dimensional; Heat-Shock Proteins; Lysine; Methionine; Methylation; Mice; Molecular Weight; omega-N-Methylarginine | 1992 |
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure.
Topics: Adult; Animals; Aorta; Arginine; Blood Pressure; Cells, Cultured; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Forearm; Guinea Pigs; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; omega-N-Methylarginine; Rats; Reference Values; Regional Blood Flow | 1992 |
Distribution of free methylarginines in rat tissues and in the bovine brain.
Topics: Animals; Arginine; Brain Chemistry; Cattle; Intestines; Male; Myocardium; omega-N-Methylarginine; Rats; Rats, Wistar; Spleen; Testis; Tissue Distribution | 1992 |
Isolation and identification of methylarginines from bovine brain.
Topics: Animals; Arginine; Brain; Cattle; Chromatography, High Pressure Liquid; Electrophoresis, Paper; omega-N-Methylarginine | 1992 |
Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pI, 8.5) rich in NG,NG-dimethylarginine.
Topics: Amino Acid Sequence; Amino Acids; Animals; Antigens; Arginine; Autoantibodies; Cell Nucleolus; Fluorescent Antibody Technique; Histocytochemistry; Humans; Immunologic Techniques; Immunosorbent Techniques; Liver Neoplasms, Experimental; Microscopy, Electron; Molecular Weight; Physarum; Proteins; RNA; Scleroderma, Systemic | 1985 |
Metabolism of NG,NG-and NG,N'G-dimethylarginine in rats.
Topics: Animals; Arginine; Carbon Dioxide; Gas Chromatography-Mass Spectrometry; Isomerism; Rats; Tissue Distribution | 1987 |
The nucleolar protein, B-36, contains a glycine and dimethylarginine-rich sequence conserved in several other nuclear RNA-binding proteins.
Topics: Amino Acid Sequence; Arginine; Carrier Proteins; Glycine; Molecular Sequence Data; Molecular Weight; Nuclear Proteins; Physarum; Protein O-Methyltransferase; RNA-Binding Proteins | 1988 |
Occurrence of a new enzyme catalyzing the direct conversion of NG,NG-dimethyl-L-arginine to L-citrulline in rats.
Topics: Amidohydrolases; Animals; Arginine; Citrulline; Female; Hydrolases; Kidney; Mass Spectrometry; Rats; Rats, Inbred Strains | 1987 |
Protein and cDNA sequence of a glycine-rich, dimethylarginine-containing region located near the carboxyl-terminal end of nucleolin (C23 and 100 kDa).
Topics: Amino Acid Sequence; Animals; Arginine; Base Sequence; Cricetinae; Cricetulus; DNA; DNA, Recombinant; Female; Glycine; Liver Neoplasms, Experimental; Nucleolin; Nucleoproteins; Ovary; Peptide Fragments; Phosphoproteins; Protein Processing, Post-Translational; RNA-Binding Proteins | 1986 |
Clustering of glycine and NG,NG-dimethylarginine in nucleolar protein C23.
Topics: Amino Acid Sequence; Animals; Arginine; Glycine; Liver Neoplasms, Experimental; Molecular Weight; Nuclear Proteins; Nucleophosmin; Peptide Fragments; Rats; Ribonucleoproteins; Structure-Activity Relationship; Trypsin | 1985 |
Urinary excretion of dimethylarginines in premature infants.
Topics: Adolescent; Adult; Aging; Arginine; Body Weight; Child; Child, Preschool; Diet; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Premature; Male; Methylhistidines; Muscle Proteins; Nitrogen; Proteins | 1984 |
Characterization of glycine-rich proteins from the ribonucleoproteins containing heterogeneous nuclear ribonucleic acid.
Topics: Arginine; Glycine; Molecular Weight; Nucleoproteins; Peptide Fragments; Ribonucleoproteins; RNA, Heterogeneous Nuclear; Thermolysin; Trypsin | 1980 |
Response of cerebral blood vessels to an endogenous inhibitor of nitric oxide synthase.
Topics: Animals; Arginine; Basilar Artery; Brain; Cerebellum; Cerebrovascular Circulation; Citrulline; Nitric Oxide Synthase; Rabbits; Rats; Rats, Sprague-Dawley | 1995 |
Effects of guanidino and uremic compounds on nitric oxide pathways.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Guanidines; Humans; Macrophages; Mice; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Saphenous Vein | 1994 |
Metabolism of methylarginines by human vasculature; implications for the regulation of nitric oxide synthesis.
Topics: Amino Acid Oxidoreductases; Arginase; Arginine; Cells, Cultured; Chromatography, High Pressure Liquid; Citrulline; Cytosol; Endothelium, Vascular; Humans; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Saphenous Vein; Umbilical Veins | 1994 |
Accumulation of an endogenous inhibitor of nitric oxide synthase during graded hemorrhagic shock.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Cardiac Output; Nitric Oxide Synthase; Shock, Hemorrhagic; Swine; Vascular Resistance | 1994 |
Effects of an endogenous inhibitor of nitric oxide synthesis on postcapillary venules.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Flow Velocity; Blood Platelets; Cell Adhesion; Cell Aggregation; Endothelium, Vascular; Kinetics; Leukocytes; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Splanchnic Circulation; Stereoisomerism; Venules | 1995 |
Urinary excretion of NG-dimethylarginines in multiple sclerosis patients: preliminary observations.
Topics: Arginine; Case-Control Studies; Chromatography, High Pressure Liquid; Humans; Multiple Sclerosis; Reference Values; Sensitivity and Specificity | 1995 |
Peptides with sequences similar to glycine, arginine-rich motifs in proteins interacting with RNA are efficiently recognized by methyltransferase(s) modifying arginine in numerous proteins.
Topics: Amino Acid Sequence; Animals; Arginine; Brain; Cattle; Chromosomal Proteins, Non-Histone; Glycine; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Methylation; Methyltransferases; Molecular Sequence Data; Nuclear Proteins; Nucleolin; PC12 Cells; Peptides; Phosphoproteins; Protein-Arginine N-Methyltransferases; Ribonucleoproteins; RNA; RNA-Binding Proteins; Sequence Homology, Amino Acid; Substrate Specificity | 1993 |
Plasma concentrations of endogenous inhibitor of nitric oxide synthesis in normal pregnancy and pre-eclampsia.
Topics: Animals; Arginine; Female; Humans; Hypertension; Nitric Oxide; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Sheep | 1993 |
Increase of an endogenous inhibitor of nitric oxide synthesis in serum of high cholesterol fed rabbits.
Topics: Animals; Arginine; Arteriosclerosis; Cholesterol, Dietary; Creatine; Lipids; Male; Nitric Oxide; Rabbits | 1994 |
Regional and cardiac haemodynamic effects of NG, NG,dimethyl-L-arginine and their reversibility by vasodilators in conscious rats.
Topics: Animals; Arginine; Glutathione; Hemodynamics; Hydralazine; Male; Nitroprusside; Nitroso Compounds; omega-N-Methylarginine; Penicillamine; Rats; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Vasodilator Agents | 1993 |
Effect of local intra-arterial asymmetric dimethylarginine (ADMA) on the forearm arteriolar bed of healthy volunteers.
Topics: Adult; Arginine; Arterioles; Female; Forearm; Humans; Injections, Intra-Arterial; Male; Regional Blood Flow; Vascular Resistance | 1993 |
Regulation of nitric oxide synthesis in uraemia.
Topics: Analysis of Variance; Animals; Arginine; Chronic Disease; Dialysis Solutions; Endothelium, Vascular; Female; Humans; Male; Mice; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Renal Dialysis; Uremia | 1995 |
Peritoneal dialysis solutions reverse the hemodynamic effects of nitric oxide synthesis inhibitors.
Topics: Animals; Arginine; Dialysis Solutions; Enzyme Inhibitors; Hemodynamics; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peritoneal Dialysis; Rats; Rats, Sprague-Dawley; Renal Insufficiency | 1995 |
Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits.
Topics: Arginine; Cholesterol, Dietary; Chromatography, High Pressure Liquid; Diet; Food, Fortified; Hypercholesterolemia; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Reference Values | 1996 |
Accumulation of the endogenous L-arginine analogue NG-monomethyl-L-arginine in human end-stage renal failure patients on regular haemodialysis.
Topics: Adult; Arginine; Biological Transport; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Erythrocytes; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase; Renal Dialysis; Scintillation Counting; Uremia | 1996 |
Effect of asymmetric dimethyl arginine on nitric oxide synthase activity in normal and pre-eclamptic placentae.
Topics: Arginine; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Nitric Oxide Synthase; Placenta; Pre-Eclampsia; Pregnancy | 1995 |
Central and peripheral effects of asymmetric dimethylarginine, an endogenous nitric oxide synthetase inhibitor.
Topics: Animals; Aorta; Arginine; Baroreflex; Dose-Response Relationship, Drug; Hemodynamics; In Vitro Techniques; Injections, Intravenous; Injections, Intraventricular; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley | 1996 |
Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension.
Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Hydrolases; Hypertension; Kidney; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium Chloride, Dietary; Species Specificity | 1997 |
High-performance liquid chromatographic determination of nitric oxide synthase-related arginine derivatives in vitro and in vivo.
Topics: Animals; Arginine; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Female; Humans; In Vitro Techniques; Macrophages, Alveolar; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Reference Values; Reproducibility of Results; Sensitivity and Specificity | 1997 |
Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arginine; Arterial Occlusive Diseases; Cyclic GMP; Disease Progression; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Peripheral Vascular Diseases; Vasodilation | 1997 |
Identification of N(G)-methylarginine residues in human heterogeneous RNP protein A1: Phe/Gly-Gly-Gly-Arg-Gly-Gly-Gly/Phe is a preferred recognition motif.
Topics: Amino Acid Sequence; Arginine; Chromatography, High Pressure Liquid; Enzyme Inhibitors; HeLa Cells; Heterogeneous Nuclear Ribonucleoprotein A1; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Heterogeneous-Nuclear Ribonucleoproteins; Humans; Methylation; Molecular Sequence Data; Peptide Mapping; Ribonucleoproteins; RNA-Binding Proteins; RNA, Heterogeneous Nuclear; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 1997 |
Effect of nicotine on the intimal hyperplasia after endothelial removal of the rabbit carotid artery.
Topics: Animals; Arginine; Body Weight; Carotid Arteries; Endothelin-1; Endothelium, Vascular; Hyperplasia; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nicotine; Nitric Oxide Synthase; omega-N-Methylarginine; Rabbits; Tunica Intima | 1997 |
Determination of dimethylated arginines in human plasma by high-performance liquid chromatography.
Topics: Arginine; Chromatography, High Pressure Liquid; Humans; Isomerism; Spectrometry, Fluorescence | 1997 |
Determination of N(G),N(G)-dimethylarginine in human plasma by high-performance liquid chromatography.
Topics: Amino Acids; Arginine; Chromatography, High Pressure Liquid; Female; Humans; Pregnancy; Pregnancy Complications, Cardiovascular; Reproducibility of Results | 1997 |
A possible role of endogenous inhibitor for nitric oxide synthesis in the bovine ciliary muscle.
Topics: Animals; Arginine; Calcimycin; Cattle; Ciliary Body; Ionophores; Muscle Relaxation; Nitric Oxide; Nitroprusside; omega-N-Methylarginine | 1997 |
Nitric oxide synthase inhibitors and hypertension in children and adolescents.
Topics: Adolescent; Animals; Arginine; Child; Endothelium, Vascular; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Humans; Hypertension; Hypertension, Renal; Hypertension, Renovascular; In Vitro Techniques; Male; Mice; Muscle Contraction; Nitric Oxide Synthase; omega-N-Methylarginine; Phenylephrine; Renin; Vasoconstrictor Agents | 1997 |
Serum levels of NG, NG-dimethyl-L-arginine, a potential endogenous nitric oxide inhibitor in dialysis patients.
Topics: Arginine; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Humans; Nitric Oxide; omega-N-Methylarginine; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis | 1997 |
The arginine-nitric oxide pathway in thrombotic microangiopathy.
Topics: Adult; Aged; Arginine; Child, Preschool; Enzyme Inhibitors; Hemolytic-Uremic Syndrome; Humans; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Plasma; Plasmapheresis; Purpura, Thrombotic Thrombocytopenic; Recurrence | 1997 |
Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney.
Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Enzyme Inhibitors; Hydrolases; Kidney Glomerulus; Loop of Henle; Male; Methylation; Microscopy, Immunoelectron; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Tritium | 1997 |
Determination of dimethylated arginines in human plasma by high-performance liquid chromatography.
Topics: Arginine; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Humans; Indicators and Reagents; Nitric Oxide Synthase; o-Phthalaldehyde; Spectrometry, Fluorescence; Stereoisomerism | 1998 |
Elevation of an endogenous inhibitor of nitric oxide synthesis in experimental congestive heart failure.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Endothelium, Vascular; Heart Failure; Kidney; Male; Metabolic Clearance Rate; Nitric Oxide Synthase; Nitroprusside; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Renal Circulation; Vasodilation; Vasodilator Agents | 1998 |
Enzymatic methylation of recombinant TIS21 protein-arginine residues.
Topics: Arginine; Escherichia coli; Immediate-Early Proteins; Methylation; Protein-Arginine N-Methyltransferases; Recombinant Proteins | 1998 |
Endogenous inhibitors of nitric oxide synthesis and lipid peroxidation in hyperlipidemic rabbits.
Topics: Animals; Aorta, Thoracic; Arginine; Hyperlipidemias; Lipid Peroxidation; Male; Malondialdehyde; Nitric Oxide; Rabbits; Vasodilation; Vitamin E | 1996 |
Endogenous asymmetrical dimethylarginine and hypertension associated with puromycin nephrosis in the rat.
Topics: Animals; Arginine; Blood Pressure; Body Weight; Cyclic GMP; Endothelium; Glomerulosclerosis, Focal Segmental; Hypertension; Kidney; Male; Nitrous Oxide; Puromycin Aminonucleoside; Rats; Rats, Sprague-Dawley | 1998 |
The nitric oxide system and cortisol-induced hypertension in humans.
Topics: Arginine; Humans; Hydrocortisone; Hypertension; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites | 1998 |
Effect of inhibition of nitric oxide synthase on Pseudomonas aeruginosa infection of respiratory mucosa in vitro.
Topics: Arginine; Bacterial Adhesion; Enzyme Inhibitors; Gene Expression; Humans; Microscopy, Electron, Scanning; Mucous Membrane; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; omega-N-Methylarginine; Organ Culture Techniques; Pseudomonas aeruginosa; Respiratory System; RNA, Messenger | 1998 |
Hemodialysis hypotension: interaction of inhibitors, iNOS, and the interdialytic period.
Topics: Adult; Arginine; Blood Pressure; Blotting, Western; Enzyme Inhibitors; Female; Humans; Hypotension; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Regression Analysis; Renal Dialysis | 1999 |
Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia.
Topics: Alloxan; Animals; Arginine; Blood Glucose; Body Weight; Carotid Arteries; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Hyperglycemia; Hyperplasia; In Vitro Techniques; Male; Nitric Oxide; omega-N-Methylarginine; Rabbits; Tunica Intima; Tunica Media; Weight Gain | 1999 |
Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis.
Topics: Adult; Aged; Arginine; Arteriosclerosis; Biomarkers; Carotid Artery, Common; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Risk Factors; Tunica Intima | 1999 |
[Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis].
Topics: Arginine; Biomarkers; Coronary Artery Disease; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase | 1999 |
Nitric oxide metabolites, cyclic guanosine 3,5 monophosphate and dimethylarginines during and after uncomplicated pregnancies: a longitudinal study.
Topics: Adult; Arginine; Chromatography, High Pressure Liquid; Creatinine; Cyclic GMP; Enzyme Inhibitors; Ethylenediamines; Female; Free Radical Scavengers; Humans; Immunoenzyme Techniques; Longitudinal Studies; Male; Nitrates; Nitric Oxide; Nitrites; Postpartum Period; Pregnancy; Reference Values; Sulfanilamides; Time Factors | 1999 |
Elevation of an endogenous inhibitor of nitric oxide synthase in diabetic rat serum.
Topics: Animals; Aorta; Arginine; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Vasodilation | 1997 |
Hepatocyte growth factor regulates human trophoblast motility and invasion: a role for nitric oxide.
Topics: Arginine; Cell Division; Cell Line; Cell Movement; Cell Size; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Induction; Female; Fibrin; Hepatocyte Growth Factor; Humans; Integrins; Interleukin-1; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; RNA, Messenger; Transfection; Trophoblasts; Tumor Necrosis Factor-alpha | 1999 |
Regulation of macrophage nitric oxide synthesis by endothelial cells: a role for NG,NG-dimethylarginine.
Topics: Animals; Arginine; Blotting, Western; Cell Count; Cell Line, Transformed; Cell Transformation, Viral; Cells, Cultured; Coculture Techniques; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III | 1999 |
Amniotic fluid nitric oxide metabolites, cyclic guanosine 3',5' monophosphate and dimethylarginine in alloimmunized pregnancies.
Topics: Amniocentesis; Amniotic Fluid; Arginine; Blood Transfusion, Intrauterine; Creatinine; Cyclic GMP; Embryonic and Fetal Development; Erythroblastosis, Fetal; Female; Gestational Age; Humans; Infant, Newborn; Nitric Oxide; Nitrites; Pregnancy; Reference Values; Regression Analysis; Retrospective Studies; Rh Isoimmunization | 1999 |
[Role of L-arginine--endogenous NOS inhibitors--endothelin-1 pathway for the vascular remodelling].
Topics: Animals; Arginine; Carotid Arteries; Cell Division; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Male; Muscle, Smooth, Vascular; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rabbits; Regeneration | 1999 |
Study on the relationship between plasma nitrite and nitrate level and salt sensitivity in human hypertension : modulation of nitric oxide synthesis by salt intake.
Topics: Adult; Aged; Arginine; Blood Pressure; Electrolytes; Female; Humans; Hypertension; Lipids; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Norepinephrine; Renin; Smoking; Sodium Chloride, Dietary; Vascular Resistance | 2000 |
Is asymmetric dimethylarginine a novel marker of atherosclerosis?
Topics: Arginine; Arteriosclerosis; Biomarkers; Carotid Arteries; Chromatography, High Pressure Liquid; Cyclic GMP; Enzyme Inhibitors; Humans; Nitrates; Nitric Oxide Synthase; Regression Analysis; Stereoisomerism; Tunica Intima | 2000 |
NG, NG-dimethylarginine and NG, NG-dimethylarginine in renal insufficiency.
Topics: Aged; Aged, 80 and over; Animals; Arginine; Blood Urea Nitrogen; Creatinine; Female; Humans; Isomerism; Male; Mice; Mice, Inbred C57BL; Middle Aged; Nephrectomy; Rats; Rats, Sprague-Dawley; Renal Insufficiency; Species Specificity; Urea | 2000 |
Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans.
Topics: Adult; Animals; Aorta; Arginine; Cattle; Cell Adhesion; Chromatography, High Pressure Liquid; Coculture Techniques; Endothelium, Vascular; Enzyme Inhibitors; Female; Flow Cytometry; Humans; Hypercholesterolemia; Leukocytes, Mononuclear; Male; Matched-Pair Analysis; Middle Aged; Nitric Oxide Synthase | 2000 |
Thyrocyte release of asymmetric dimethylarginine does not account for human thyrocyte inhibition of endothelial cell cyclic GMP.
Topics: Arginine; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide Synthase; Radioimmunoassay; Thyroid Gland; Umbilical Veins | 2000 |
Determination of asymmetrical dimethylarginine by capillary electrophoresis-laser-induced fluorescence.
Topics: Arginine; Calibration; Electrophoresis, Capillary; Fluorescence; Humans; Kidney Failure, Chronic; Lasers; Reproducibility of Results; Sensitivity and Specificity | 2000 |
Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia.
Topics: Animals; Arginine; Cell Line, Transformed; Cholesterol; Diet; Dietary Fats; Endothelium, Vascular; Enzyme Inhibitors; Homocysteine; Humans; Hypercholesterolemia; Hyperhomocysteinemia; Macaca fascicularis; Methionine; Nitric Oxide Synthase; Regression Analysis; Vasodilation | 2000 |
Vascular endothelial cell activation associated with increased plasma asymmetric dimethyl arginine in children and young adults with hypertension: a basis for atheroma?
Topics: Adolescent; Adult; Arginine; Arteriosclerosis; Child; Child, Preschool; Endothelium, Vascular; Female; Glomerular Filtration Rate; Humans; Hypertension; Infant; Male; Vascular Cell Adhesion Molecule-1 | 2000 |
LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases.
Topics: Arginine; Cell Line; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Humans; Kinetics; Lipoproteins, LDL; Methionine; Nitric Oxide Synthase; Protein-Arginine N-Methyltransferases; S-Adenosylmethionine | 2000 |
Endogenous nitric oxide synthase inhibitors are responsible for the L-arginine paradox.
Topics: Animals; Arginine; Binding, Competitive; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Meta-Analysis as Topic; Models, Biological; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Thermodynamics | 2000 |
Nitric oxide improves membrane fluidity of erythrocytes in essential hypertension: An electron paramagnetic resonance investigation.
Topics: Arginine; Blood Pressure; Calcimycin; Cell Membrane; Cyclic GMP; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Erythrocytes; Hemorheology; Humans; Hypertension; Membrane Fluidity; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Penicillamine; Spin Labels | 2000 |
Hypercholesterolemia inhibits angiogenesis in response to hindlimb ischemia: nitric oxide-dependent mechanism.
Topics: Administration, Oral; Animals; Arginine; Body Weight; Cholesterol, Dietary; Collateral Circulation; Cyclic GMP; Endothelium, Vascular; Hindlimb; Hypercholesterolemia; Immunohistochemistry; Ischemia; Laser-Doppler Flowmetry; Lipids; Male; Neovascularization, Physiologic; Nitrates; Nitric Oxide; Nitrites; Rats; Rats, Sprague-Dawley; Regional Blood Flow | 2000 |
Serum concentrations of asymmetric (ADMA) and symmetric (SDMA) dimethylarginine in renal failure patients.
Topics: Adult; Aged; Amino Acids; Arginine; Blood Pressure; Case-Control Studies; Creatinine; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Renal Dialysis | 2001 |
Increased reduction of dimethylarginines and lowered interdialytic blood pressure by the use of biocompatible membranes.
Topics: Adult; Aged; Arginine; beta 2-Microglobulin; Biocompatible Materials; Blood Pressure; Diabetic Nephropathies; Female; Hematocrit; Hemodiafiltration; Hemoglobins; Humans; Kidney Failure, Chronic; Kidneys, Artificial; Male; Membranes, Artificial; Middle Aged; Renal Dialysis; Urea | 2001 |
Comment: the asymmetrical dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in the regulation of nitric oxide generation.
Topics: Amidohydrolases; Arginine; Endothelium, Vascular; Humans; Hydrolases; Hyperhomocysteinemia; Nitric Oxide | 2001 |
Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inaemia in humans.
Topics: Acute Disease; Adult; Arginine; Brachial Artery; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Nitroglycerin; Vasodilation; Vasodilator Agents | 2001 |
Reversible sequestration of nitric oxide by hemoglobin during hemodialysis in end-stage renal disease.
Topics: Anemia; Arginine; Erythropoietin; Hematocrit; Hemoglobins; Humans; Hypotension; Kidney Failure, Chronic; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Renal Dialysis; Skin Temperature | 2001 |
Circulating endothelial nitric oxide synthase inhibitory factor in some patients with chronic renal disease.
Topics: Adult; Aged; Arginine; Blood Physiological Phenomena; Blood Urea Nitrogen; Cells, Cultured; Creatinine; Endothelium, Vascular; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Reference Values; Skin | 2001 |
Plasma levels of asymmetrical dimethyl-L-arginine in patients with congenital heart disease and pulmonary hypertension.
Topics: Adolescent; Adult; Arginine; Child; Child, Preschool; Enzyme Inhibitors; Heart Defects, Congenital; Hemodynamics; Humans; Hypertension, Pulmonary; Infant; Nitric Oxide Synthase | 2001 |
Methylation of histone H3 by coactivator-associated arginine methyltransferase 1.
Topics: Amino Acid Sequence; Amino Acids; Animals; Arginine; Catalysis; Cattle; Chickens; Chromatography, High Pressure Liquid; Enzyme Activation; Histones; Kinetics; Methylation; Molecular Sequence Data; Oligopeptides; omega-N-Methylarginine; Protein-Arginine N-Methyltransferases; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity | 2001 |
Dimethylarginines in chronic renal failure.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Chromatography, High Pressure Liquid; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis | 2001 |
SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets.
Topics: Amino Acid Sequence; Arginine; Autoantigens; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; HeLa Cells; Humans; Methylation; Molecular Sequence Data; Muscular Atrophy, Spinal; Nerve Tissue Proteins; Protein Binding; Recombinant Fusion Proteins; Ribonucleoproteins, Small Nuclear; RNA-Binding Proteins; SMN Complex Proteins; snRNP Core Proteins; Substrate Specificity | 2001 |
Estriol improves membrane fluidity of erythrocytes by the nitric oxide-dependent mechanism: an electron paramagnetic resonance study.
Topics: Arginine; Cyclic GMP; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Erythrocyte Membrane; Estriol; Female; Humans; In Vitro Techniques; Male; Membrane Fluidity; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine | 2001 |
PRMT5 (Janus kinase-binding protein 1) catalyzes the formation of symmetric dimethylarginine residues in proteins.
Topics: Arginine; Binding Sites; HeLa Cells; Humans; Methylation; Models, Molecular; Myelin Basic Protein; Protein Conformation; Protein Methyltransferases; Protein-Arginine N-Methyltransferases; Recombinant Fusion Proteins; Recombinant Proteins; S-Adenosylmethionine | 2001 |
Levels of dimethylarginines and cytokines in mild and severe preeclampsia.
Topics: Arginine; Blood Pressure; Cytokines; Female; Gestational Age; Humans; Nitric Oxide Synthase; Pre-Eclampsia; Pregnancy; Statistics, Nonparametric; Uric Acid | 2001 |
Mild-to-moderate hypertriglyceridemia in young men is associated with endothelial dysfunction and increased plasma concentrations of asymmetric dimethylarginine.
Topics: Adult; Arginine; Brachial Artery; Carotid Artery, Common; Endothelium, Vascular; Humans; Hypertriglyceridemia; Male; Nitric Oxide Synthase; Ultrasonography, Interventional; Vasodilation | 2001 |
Electron paramagnetic resonance investigation on modulatory effect of 17beta-estradiol on membrane fluidity of erythrocytes in postmenopausal women.
Topics: Aged; Arginine; Cyclic GMP; Electron Spin Resonance Spectroscopy; Erythrocytes; Estradiol; Female; Humans; Hypertension; In Vitro Techniques; Membrane Fluidity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Postmenopause; S-Nitroso-N-Acetylpenicillamine | 2001 |
Elevated serum endogenous inhibitor of nitric oxide synthase and endothelial dysfunction in aged rats.
Topics: Acetylcholine; Aging; Animals; Aorta, Thoracic; Arginine; Endothelium, Vascular; Kidney; Male; Nitric Oxide Synthase; Nitrites; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2001 |
Elevated levels of plasma homocyst(e)ine and asymmetric dimethylarginine in elderly patients with stroke.
Topics: Aged; Aged, 80 and over; Arginine; Cerebral Infarction; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Female; Homocysteine; Humans; Logistic Models; Male; Nitric Oxide Synthase; Recurrence; Risk Factors; Stroke | 2001 |
Reduction in asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in the cerebrospinal fluid during aging and in patients with Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Arginine; Brain; Female; Humans; Male; Middle Aged; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress | 2001 |
Effect of asymmetric dimethylarginine on osteoblastic differentiation.
Topics: Alkaline Phosphatase; Animals; Arginine; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Female; Kidney Failure, Chronic; Mice; Nitric Oxide; Osteoblasts; RNA, Messenger | 2001 |
Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus.
Topics: Arginine; Blood Glucose; Case-Control Studies; Cholesterol; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase | 2001 |
The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins.
Topics: Arginine; Blotting, Western; Carrier Proteins; Cell Survival; Cells, Cultured; Cytoplasm; DNA; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epitopes; Glutathione Transferase; Humans; Mass Spectrometry; Methylation; Methyltransferases; Models, Biological; Precipitin Tests; Protein Binding; Protein Methyltransferases; Protein Structure, Tertiary; Protein-Arginine N-Methyltransferases; Recombinant Fusion Proteins; Recombinant Proteins; Sucrose; Transfection | 2001 |
Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine.
Topics: Amidohydrolases; Animals; Aorta; Arginine; Arteriosclerosis; Cattle; Cell Line; Culture Techniques; Endothelium, Vascular; Homocysteine; Hydrolases; Hyperhomocysteinemia; Kinetics; Methionine; Nitric Oxide; Nitric Oxide Synthase; Recombinant Fusion Proteins; Signal Transduction | 2001 |
Marked increase of asymmetric dimethylarginine in patients with incipient primary chronic renal disease.
Topics: Adult; Arginine; Creatinine; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Osmolar Concentration; Reference Values; Severity of Illness Index | 2002 |
Endogenous nitric oxide synthase inhibitors in endothelial cells, endothelin-1 within the vessel wall, and intimal hyperplasia in perimenopausal human uterine arteries.
Topics: Adult; Arginine; Arteries; Chromatography, High Pressure Liquid; Climacteric; Cyclic GMP; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hyperplasia; In Vitro Techniques; Middle Aged; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Tunica Intima; Tunica Media; Uterus | 2002 |
Asymmetric dimethylarginine, C-reactive protein, and carotid intima-media thickness in end-stage renal disease.
Topics: Adult; Aged; Arginine; C-Reactive Protein; Carotid Arteries; Cohort Studies; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic; Male; Middle Aged; Single-Blind Method; Tunica Intima; Tunica Media; Ultrasonography, Doppler, Color | 2002 |
Hemodynamic changes during hemodialysis: role of nitric oxide and endothelin.
Topics: Adult; Aged; Arginine; Endothelin-1; Female; Humans; Hypertension, Renal; Hypotension; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Renal Dialysis | 2002 |
Probucol preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level.
Topics: Animals; Aorta, Thoracic; Arginine; Endothelium, Vascular; Enzyme Inhibitors; Lipoproteins, LDL; Male; Malondialdehyde; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Probucol; Rats; Rats, Sprague-Dawley; Vasodilation | 2002 |
High NaCl intake decreases both flow-induced dilation and pressure-induced myogenic tone in resistance arteries from normotensive rats: involvement of cyclooxygenase-2.
Topics: Animals; Arginine; Blood Pressure; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Endothelium, Vascular; Indomethacin; Isoenzymes; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred WKY; Regional Blood Flow; Sodium Chloride, Dietary; Sulfonamides; Vasodilation | 2001 |
Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor.
Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Cross-Sectional Studies; Enzyme Inhibitors; Female; Humans; Hypertension; Hypoglycemic Agents; Lipoproteins; Male; Metabolic Diseases; Metabolic Syndrome; Middle Aged; Nitric Oxide Synthase; Regression Analysis; Risk Factors; Rosiglitazone; Thiazoles; Thiazolidinediones; Vasodilator Agents | 2002 |
Insulin resistance, ADMA levels, and cardiovascular disease.
Topics: Arginine; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Insulin Resistance; Metabolic Syndrome; Nitric Oxide Synthase; Risk Factors | 2002 |
Myocardial proteome analysis reveals reduced NOS inhibition and enhanced glycolytic capacity in areas of low local blood flow.
Topics: Amidohydrolases; Animals; Arginine; Coronary Circulation; Dogs; Electrophoresis, Gel, Two-Dimensional; Energy Metabolism; Enzyme Inhibitors; Fatty Acids; Glycolysis; Hydrolases; Kinetics; Mass Spectrometry; Models, Cardiovascular; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Proteome | 2002 |
Determination of arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in human plasma and other biological samples by high-performance liquid chromatography.
Topics: Arginine; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Humans; In Vitro Techniques; Quality Control | 2002 |
Localization and role of nitric oxide synthase and endogenous nitric oxide synthase inhibitors in the rabbit lower urinary tract.
Topics: Animals; Arginine; Culture Techniques; Enzyme Inhibitors; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rabbits; Urethra; Urinary Bladder | 2002 |
all-trans-Retinoic acid increases nitric oxide synthesis by endothelial cells: a role for the induction of dimethylarginine dimethylaminohydrolase.
Topics: Amidohydrolases; Arginine; Blotting, Northern; Cell Line; Endothelium, Vascular; Enzyme Induction; Enzyme Inhibitors; Genes, Reporter; Isoenzymes; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Promoter Regions, Genetic; RNA, Messenger; Tretinoin | 2002 |
Helicobacter pylori infection inhibits antral mucosal nitric oxide production in humans.
Topics: Adolescent; Adult; Aged; Arginine; Biopsy, Needle; Blotting, Western; Chromatography, High Pressure Liquid; Female; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pyloric Antrum; Up-Regulation | 2002 |
Nitric oxide and angiogenesis.
Topics: Angiogenesis Inhibitors; Angiostatins; Animals; Arginine; Arteriosclerosis; Coronary Circulation; Dogs; Endothelium, Vascular; Matrix Metalloproteinases; Myocardial Ischemia; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Plasminogen | 2002 |
Accumulated endogenous NOS inhibitors, decreased NOS activity, and impaired cavernosal relaxation with ischemia.
Topics: Animals; Arginine; Calcium; Carbachol; Cholinergic Agonists; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Endothelium, Vascular; Enzyme Inhibitors; Iliac Artery; Impotence, Vasculogenic; In Vitro Techniques; Ischemia; Male; Nitric Oxide Synthase; omega-N-Methylarginine; Penis; Rabbits; Vasoconstrictor Agents; Vasodilator Agents | 2002 |
Left ventricular hypertrophy, cardiac remodeling and asymmetric dimethylarginine (ADMA) in hemodialysis patients.
Topics: Adult; Aged; Arginine; Echocardiography; Endothelium, Vascular; Female; Humans; Hypertrophy, Left Ventricular; Kidney Failure, Chronic; Male; Middle Aged; Multivariate Analysis; Nitric Oxide; Renal Dialysis; Vasodilation; Ventricular Dysfunction, Left | 2002 |
Endogenous methylarginines regulate neuronal nitric-oxide synthase and prevent excitotoxic injury.
Topics: Animals; Arginine; Cell Survival; Cells, Cultured; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; omega-N-Methylarginine; Rats | 2002 |
Effect of age on bone mineral density and the serum concentration of endogenous nitric oxide synthase inhibitors in rats.
Topics: Absorptiometry, Photon; Aging; Animals; Arginine; Bone and Bones; Bone Density; Enzyme Inhibitors; Male; Malondialdehyde; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 2002 |
Reduced nitric oxide synthase activity in rats with chronic renal disease due to glomerulonephritis.
Topics: Animals; Antibodies; Arginine; Autoantibodies; Blood Urea Nitrogen; Creatinine; Glomerulonephritis; Kidney Failure, Chronic; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrites; Proteinuria; Rats; Rats, Sprague-Dawley | 2002 |
Blunted acetylcholine relaxation and nitric oxide release in arteries from renal hypertensive rats.
Topics: Acetylcholine; Animals; Arginine; Free Radical Scavengers; Hypertension, Renovascular; In Vitro Techniques; Male; Mesenteric Artery, Superior; Nitric Oxide; Nitric Oxide Donors; Oxyhemoglobins; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase; Vasodilation | 2002 |
Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase.
Topics: Amidohydrolases; Animals; Antioxidants; Aorta; Arginine; Cell Line; Cells, Cultured; Cyclic GMP; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Glucose; Humans; Male; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Oxidative Stress; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2002 |
Endothelin stimulates an endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, in experimental heart failure.
Topics: Animals; Arginine; Cardiac Output; Cardiac Pacing, Artificial; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Heart Failure; Models, Animal; Nitric Oxide Synthase; Pyrimidines; Random Allocation; Receptor, Endothelin A; Sulfonamides; Vascular Resistance | 2002 |
Alzheimer's disease is not associated with altered concentrations of the nitric oxide synthase inhibitor asymmetric dimethylarginine in cerebrospinal fluid.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Arginine; Brain; Cytoskeleton; Dimethylamines; Female; Humans; Male; Middle Aged; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Peptide Fragments; tau Proteins | 2002 |
Endothelial damage, asymmetric dimethylarginine and cardiovascular risk in end-stage renal disease.
Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Kidney Failure, Chronic; Models, Cardiovascular; Risk Factors | 2002 |
Angiotensin-converting enzyme activity is involved in the mechanism of increased endogenous nitric oxide synthase inhibitor in patients with type 2 diabetes mellitus.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Arginine; Cross-Over Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Immunoassay; Male; Nitric Oxide Synthase; Peptidyl-Dipeptidase A; Perindopril; Renin-Angiotensin System; von Willebrand Factor | 2002 |
Homocysteine and ADMA--emerging risk factors for cardiovascular disease?
Topics: Arginine; Cardiovascular Diseases; Homocysteine; Humans; Predictive Value of Tests; Risk Factors | 2002 |
Circulating concentrations of asymmetrical dimethyl-L-arginine are increased in women with previous gestational diabetes.
Topics: Adult; Arginine; Biomarkers; Body Mass Index; Diabetes, Gestational; Female; Follow-Up Studies; Humans; Postpartum Period; Pregnancy | 2002 |
Plasma asymmetric dimethylarginine and hyperemic myocardial blood flow in young subjects with borderline hypertension or familial hypercholesterolemia.
Topics: Adult; Age Factors; Arginine; Biomarkers; Blood Flow Velocity; Case-Control Studies; Coronary Circulation; Cross-Sectional Studies; Dipyridamole; Humans; Hyperemia; Hyperlipoproteinemia Type II; Hypertension; Linear Models; Male; Multivariate Analysis; Nitric Oxide Synthase; Tomography, Emission-Computed; Vasodilator Agents | 2002 |
Net renal extraction of asymmetrical (ADMA) and symmetrical (SDMA) dimethylarginine in fasting humans.
Topics: Aged; Arginine; Arteries; Creatinine; Fasting; Female; Humans; Kidney; Male; Middle Aged; Molecular Conformation; Osmolar Concentration | 2002 |
Hypertension in relation to nitric oxide, asymmetric dimethylarginine, and inflammation: different patterns in heart transplant recipients and individuals with essential hypertension.
Topics: Arginine; Blood Pressure; Female; Heart Transplantation; Humans; Hypertension; Inflammation; Male; Middle Aged; Nitric Oxide; Tumor Necrosis Factor-alpha | 2002 |
Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in hyperthyroid patients.
Topics: Adult; Aged; Arginine; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Osmolar Concentration; Reference Values | 2002 |
Endothelium-dependent vasorelaxation and the expression of calcitonin gene-related peptide in aged rats.
Topics: Aging; Animals; Arginine; Calcitonin Gene-Related Peptide; Endothelium, Vascular; Gene Expression; Male; Phenylephrine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Vasoconstrictor Agents; Vasodilation | 2002 |
Presence of methylated arginine derivatives in orthotopic human liver transplantation: relevance for liver function.
Topics: Animals; Arginine; Cells, Cultured; Chromatography, High Pressure Liquid; Female; Hepatocytes; Humans; Liver Transplantation; Male; Middle Aged; Nitric Oxide Synthase; Postoperative Period; Rats; Reperfusion Injury | 2003 |
Reduction of total homocysteine levels by oral folic acid fails to improve endothelial function in children with chronic renal failure.
Topics: Administration, Oral; Arginine; Child; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Vasodilation | 2003 |
Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, in maternal and fetal circulation.
Topics: Adolescent; Adult; Arginine; Enzyme Inhibitors; Female; Fetal Blood; Gestational Age; Humans; Labor, Obstetric; Nitric Oxide Synthase; Pregnancy; Reference Values; Umbilical Veins | 2003 |
The liver is an important organ in the metabolism of asymmetrical dimethylarginine (ADMA).
Topics: Animals; Arginine; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Kidney; Liver; Liver Circulation; Male; Rats; Rats, Wistar; Regional Blood Flow; Renal Circulation | 2003 |
Asymmetrical dimethylarginine (ADMA) in critically ill patients: high plasma ADMA concentration is an independent risk factor of ICU mortality.
Topics: Adult; Aged; Analysis of Variance; Arginine; Critical Illness; Cross-Sectional Studies; Enzyme Inhibitors; Female; Humans; Intensive Care Units; Liver Failure; Male; Middle Aged; Multiple Organ Failure; Pilot Projects; Renal Insufficiency; Risk Factors | 2003 |
The asymmetrical dimethylarginine (ADMA)-multiple organ failure hypothesis.
Topics: Arginine; Critical Illness; Enzyme Inhibitors; Humans; Liver; Multiple Organ Failure; Nitric Oxide | 2003 |
Regulation of cytokine-induced nitric oxide synthesis by asymmetric dimethylarginine: role of dimethylarginine dimethylaminohydrolase.
Topics: Amidohydrolases; Animals; Arginine; Cells, Cultured; Culture Media, Conditioned; Cytokines; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Interleukin-1; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Transfection | 2003 |
[Relationship between serum asymmetric dimethylarginine and blood pressure in patients with chronic renal failure].
Topics: Adult; Arginine; Chromatography, High Pressure Liquid; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase; Renal Dialysis | 2002 |
Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxia.
Topics: Amidohydrolases; Animals; Animals, Newborn; Arginine; Hypertension, Pulmonary; Hypoxia; Immunohistochemistry; Lung; Male; Pressure; Protein Isoforms; Rats; Rats, Sprague-Dawley; RNA, Messenger; Swine | 2003 |
Plasma concentrations of asymmetric-dimethyl-arginine in type 2 diabetes associate with glycemic control and glomerular filtration rate but not with risk factors of vasculopathy.
Topics: Aged; Arginine; Blood Glucose; Blood Pressure; Cholesterol; Cholesterol, HDL; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Glomerular Filtration Rate; Glycated Hemoglobin; Humans; Insulin; Linear Models; Male; Middle Aged; Risk Factors; Triglycerides | 2003 |
Significance of asymmetric dimethylarginine (ADMA) concentrations during coronary circulation in patients with vasospastic angina.
Topics: Aged; Angina Pectoris; Arginine; Case-Control Studies; Coronary Angiography; Coronary Circulation; Coronary Vasospasm; Coronary Vessels; Enzyme Inhibitors; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitrites; Osmolar Concentration; Risk Factors; Vasodilator Agents; Vasomotor System | 2003 |
Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects.
Topics: Adult; Aged; Aging; Arginine; Blood Pressure; Female; Glomerular Filtration Rate; Hemodynamics; Humans; Hypertension; Kidney; Male; Renal Circulation; Renal Plasma Flow, Effective | 2003 |
Oestrogen and the cardiovascular system.
Topics: Arginine; Cardiovascular Physiological Phenomena; Coronary Disease; Endothelium, Vascular; Estrogens, Conjugated (USP); Female; Humans; Lipid Metabolism; Male; Nitric Oxide; Nitric Oxide Synthase; Risk Factors; Selective Estrogen Receptor Modulators | 2003 |
ADMA: a critical cardio-renal link in heart failure?
Topics: Arginine; Heart Failure; Humans; Kidney Failure, Chronic; Nitric Oxide | 2003 |
Endogenous nitric oxide synthase inhibitors and renal perfusion in patients with heart failure.
Topics: Aged; Arginine; Endothelium, Vascular; Heart Failure; Humans; Kidney Diseases; Male; Renal Circulation; Vasodilation | 2003 |
Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia.
Topics: Arginine; Brachial Artery; Endothelium, Vascular; Female; Humans; Placental Circulation; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Ultrasonography, Doppler, Color; Ultrasonography, Prenatal; Uterus; Vasodilation | 2003 |
High-performance liquid chromatographic assay of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine in human plasma by derivatization with naphthalene-2,3-dicarboxaldehyde.
Topics: Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Naphthalenes; Reference Standards; Reproducibility of Results; Spectrometry, Fluorescence; Stereoisomerism | 2003 |
Metabolism-based inactivation of neuronal nitric-oxide synthase by components of cigarette and cigarette smoke.
Topics: Arginine; Calmodulin; Enzyme Inhibitors; NADP; Nicotiana; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Smoke; Solubility; Water | 2003 |
Nitric oxide inhibition as a mechanism for blood pressure increase during salt loading in normotensive postmenopausal women.
Topics: Arginine; Blood Pressure; Brachial Artery; Endothelium, Vascular; Female; Humans; Middle Aged; Natriuresis; Nitric Oxide; Postmenopause; Predictive Value of Tests; Regression Analysis; Sodium Chloride, Dietary; Vasodilation | 2003 |
Increased asymmetric dimethylarginine and endothelin 1 levels in secondary Raynaud's phenomenon: implications for vascular dysfunction and progression of disease.
Topics: Adult; Arginine; Brachial Artery; Chemokine CCL2; Cold Temperature; Disease Progression; Endothelin-1; Female; Humans; Laser-Doppler Flowmetry; Male; Microcirculation; Middle Aged; Raynaud Disease; Vascular Cell Adhesion Molecule-1; Vascular Resistance; Vasoconstriction | 2003 |
Elevated levels of the serum endogenous inhibitor of nitric oxide synthase and metabolic control in rats with streptozotocin-induced diabetes.
Topics: Animals; Arginine; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Insulin; Male; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 2003 |
Dimethylarginine dimethylaminohydrolase activity modulates ADMA levels, VEGF expression, and cell phenotype.
Topics: Amidohydrolases; Arginine; Blotting, Northern; Cells, Cultured; Collagen; Drug Combinations; Endothelial Growth Factors; Endothelium, Vascular; Humans; Immunoblotting; Intercellular Signaling Peptides and Proteins; Laminin; Lymphokines; Phenotype; Plasmids; Proteoglycans; RNA, Messenger; Time Factors; Transfection; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension.
Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Chronic Disease; Disease Models, Animal; Enzyme Activation; Hypertension, Pulmonary; Hypoxia; Isoenzymes; Lung; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Rats; Rats, Sprague-Dawley | 2003 |
Estrogen stimulates dimethylarginine dimethylaminohydrolase activity and the metabolism of asymmetric dimethylarginine.
Topics: Amidohydrolases; Arginine; Cardiotonic Agents; Cell Line; Drug Implants; Endothelium, Vascular; Enzyme Activation; Estradiol; Female; Humans; Middle Aged; Postmenopause; Receptors, Estrogen; Tamoxifen | 2003 |
Asymmetrical dimethylarginine and multiple organ failure.
Topics: Animals; Arginine; Enzyme Inhibitors; Liver; Multiple Organ Failure; Nitric Oxide; Nitric Oxide Synthase; Rats | 2003 |
Elevated plasma and urine levels of ADMA and 15(S)-8-iso-PGF2alpha in end-stage liver disease.
Topics: Adult; Aged; Arginine; Dinoprost; F2-Isoprostanes; Female; Humans; Kidney Failure, Chronic; Liver Diseases; Male; Middle Aged | 2003 |
High plasma level of asymmetric dimethylarginine in patients with acutely exacerbated congestive heart failure: role in reduction of plasma nitric oxide level.
Topics: Acute Disease; Arginine; Chromatography, High Pressure Liquid; Chronic Disease; Cytokines; Enzyme Inhibitors; Female; Heart Failure; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Tumor Necrosis Factor-alpha | 2003 |
Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells.
Topics: Amidohydrolases; Arginine; Cell Line, Transformed; Endothelium, Vascular; Gene Expression Regulation; Humans; Microscopy, Fluorescence; NF-kappa B; Protein-Arginine N-Methyltransferases; Stress, Mechanical; Transcription Factor RelA | 2003 |
Asymmetrical dimethylarginine: a novel risk factor for coronary artery disease.
Topics: Aged; Arginine; Biomarkers; Coronary Angiography; Coronary Artery Disease; Exercise Test; Female; Humans; Male; Multivariate Analysis; Nitric Oxide Synthase; Predictive Value of Tests; Prospective Studies; Risk Factors | 2003 |
When the endothelium cannot say 'NO' anymore. ADMA, an endogenous inhibitor of NO synthase, promotes cardiovascular disease.
Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Nitric Oxide; Nitric Oxide Synthase | 2003 |
Plasma levels of asymmetrical dimethylarginine and adverse cardiovascular events after percutaneous coronary intervention.
Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Coronary Disease; Death, Sudden, Cardiac; Female; Follow-Up Studies; Humans; Male; Multivariate Analysis; Myocardial Infarction; Nitric Oxide Synthase; Prospective Studies; Risk Factors; Survival Analysis | 2003 |
Asymmetric dimethylarginine and total homocysteine in plasma after oral methionine loading.
Topics: Administration, Oral; Adult; Arginine; Homocysteine; Humans; Male; Methionine; Middle Aged; Time Factors | 2003 |
Handling of asymmetrical dimethylarginine and symmetrical dimethylarginine by the rat kidney under basal conditions and during endotoxaemia.
Topics: Animals; Arginine; Biological Transport; Endotoxemia; Enzyme Inhibitors; Kidney; Lipopolysaccharides; Male; Microspheres; Nitric Oxide Synthase; Rats; Rats, Wistar; Renal Circulation | 2003 |
The protective effects of monophosphoryl lipid A on the ischemic myocardium and endothelium in rats.
Topics: Animals; Arginine; Cholesterol, LDL; Creatine Kinase; Endothelium, Vascular; Heart; Lipid A; Male; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Vasodilation | 2003 |
Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease.
Topics: Aged; Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Mitochondrial Proton-Translocating ATPases; Oxidative Phosphorylation Coupling Factors; Radioimmunoassay; Risk Factors | 2003 |
Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence.
Topics: Amidohydrolases; Animals; Arginine; Cells, Cultured; Endothelium; Hemodynamics; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Nitric Oxide Synthase; Transfection | 2003 |
Asymmetric dimethylarginine (ADMA): a key regulator of nitric oxide synthase.
Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Homeostasis; Humans; Hyperhomocysteinemia; Hyperlipidemias; Nitric Oxide Synthase; Vasodilation | 2003 |
Cytomegalovirus infection impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine in transplant arteriosclerosis.
Topics: Amidohydrolases; Arginine; Cardiovascular Diseases; Cells, Cultured; Coronary Angiography; Coronary Artery Disease; Cyclic GMP; Cytomegalovirus Infections; Endothelium, Vascular; Female; Heart Transplantation; Humans; Male; Middle Aged; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Risk Factors; Signal Transduction | 2004 |
Analysis of the relationship between norepinephrine and asymmetric dimethyl arginine levels among patients with end-stage renal disease.
Topics: Arginine; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic; Male; Middle Aged; Norepinephrine; Survival Analysis; Time Factors | 2004 |
Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction.
Topics: Arginine; Cerebrovascular Circulation; DNA Methylation; Homocysteine; Humans; Hyperhomocysteinemia; Oxidative Stress; Reactive Oxygen Species; Risk Factors; Stroke | 2004 |
Asymmetric dimethylarginine and circulatory disorders in postmenopausal women.
Topics: Aged; Arginine; Endothelium, Vascular; Estrogen Replacement Therapy; Female; Humans; Middle Aged; Peripheral Vascular Diseases; Postmenopause; Vasodilation | 2004 |
Plasma concentrations of asymmetric dimethylarginine (ADMA) in Colombian women with pre-eclampsia.
Topics: Adult; Arginine; Case-Control Studies; Colombia; Female; Humans; Pre-Eclampsia; Pregnancy | 2004 |
Upregulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in endothelial cells by nitric oxide deficiency.
Topics: Arginine; Arteriosclerosis; Blotting, Western; Cell Culture Techniques; Endothelial Cells; Enzyme Inhibitors; Gene Expression Regulation; Humans; Kidney Failure, Chronic; Lipid Metabolism; Nitric Oxide; Nitric Oxide Synthase; Receptors, LDL; Receptors, Oxidized LDL; Reverse Transcriptase Polymerase Chain Reaction; Scavenger Receptors, Class E; Up-Regulation | 2004 |
Asymmetric dimethylarginine upregulates LOX-1 in activated macrophages: role in foam cell formation.
Topics: Arginine; Cell Differentiation; Endothelium, Vascular; Enzyme Inhibitors; Foam Cells; Free Radical Scavengers; HL-60 Cells; Humans; Lipoproteins, LDL; Macrophages; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Receptors, Cell Surface; Receptors, LDL; RNA, Small Interfering; Umbilical Veins; Up-Regulation | 2004 |
Estrogen and asymmetric dimethylarginine in postmenopausal women.
Topics: Amidohydrolases; Arginine; Endothelium, Vascular; Erythrocyte Membrane; Estradiol; Estrogen Replacement Therapy; Female; Hemodynamics; Humans; Membrane Fluidity; Middle Aged; Nitric Oxide; Postmenopause | 2004 |
Changes in the dimeric state of neuronal nitric oxide synthase affect the kinetics of secretagogue-induced insulin response.
Topics: Animals; Arginine; Carrier Proteins; Cell Line; Dimerization; Drosophila Proteins; Dyneins; Enzyme Inhibitors; Glucose; Indazoles; Insulin; Insulin Secretion; Kinetics; Male; Miconazole; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroarginine; Nitroprusside; Rats; Rats, Wistar; Surface Plasmon Resonance | 2004 |
Homocysteine induces oxidative stress by uncoupling of NO synthase activity through reduction of tetrahydrobiopterin.
Topics: Antioxidants; Arginine; Ascorbic Acid; Biopterins; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Ethidium; Fluorescent Dyes; Homocysteine; Humans; L-Lactate Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Pterins; Reactive Nitrogen Species; Superoxides; Thrombin; Time Factors | 2004 |
Homocysteine, vitamin B6, and endothelial dysfunction in circulatory disorders.
Topics: Arginine; C-Reactive Protein; Endothelium, Vascular; Homocysteine; Humans; Nitric Oxide; Pyridoxal Phosphate; Stroke; Vitamin B 6; Vitamin B 6 Deficiency | 2004 |
Involvement of increased arginase activity in impaired cavernous relaxation with aging in the rabbit.
Topics: Aging; Animals; Arginase; Arginine; Carbachol; Cholinergic Agonists; Endothelium, Vascular; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; omega-N-Methylarginine; Penis; Rabbits | 2004 |
Effects of concentrated fine ambient particles on rat plasma levels of asymmetric dimethylarginine.
Topics: Air Pollutants; Animals; Arginine; Atmosphere Exposure Chambers; Inhalation Exposure; Male; Meteorological Concepts; Nitric Oxide Synthase; Particle Size; Pilot Projects; Rats; Rats, Inbred BN | 2004 |
Effect of simvastatin on endothelium-dependent vaso-relaxation and endogenous nitric oxide synthase inhibitor.
Topics: Animals; Arginine; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Humans; Lipoproteins, LDL; Male; Monocytes; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Simvastatin; Tumor Necrosis Factor-alpha; Umbilical Cord; Vasodilation | 2004 |
Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice: involvement of renin-angiotensin system and oxidative stress.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Coronary Disease; Enzyme Induction; Homocysteine; Imidazoles; Infusion Pumps, Implantable; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcirculation; Myocardium; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Olmesartan Medoxomil; omega-N-Methylarginine; Oxidative Stress; Peptidyl-Dipeptidase A; Renin-Angiotensin System; Superoxides; Tetrazoles; Thiazepines | 2004 |
Cardiovascular effects of asymmetric dimethylarginine.
Topics: Amidohydrolases; Animals; Arginine; Double-Blind Method; Guinea Pigs; Hemodynamics; Humans; Randomized Controlled Trials as Topic | 2004 |
Plasma concentrations of nitric oxide and asymmetric dimethylarginine in human alcoholic cirrhosis.
Topics: Arginine; Endothelium, Vascular; Female; Humans; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Vasodilation | 2004 |
17beta-estradiol preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level.
Topics: Analysis of Variance; Animals; Aorta, Thoracic; Arginine; Cholesterol, LDL; Disease Models, Animal; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Estradiol; Male; Malondialdehyde; Nitric Oxide Synthase; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity | 2004 |
Sex hormones and asymmetric dimethylarginine in transplant arteriosclerosis.
Topics: Arginine; Coronary Artery Disease; Endothelium, Vascular; Estrogens; Female; Gonadal Steroid Hormones; Heart Transplantation; Humans; Male | 2004 |
Serum homocysteine and endothelial dysfunction in circulatory disorders in women.
Topics: Arginine; Coronary Disease; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Middle Aged; Myocardial Infarction; Nitric Oxide; Risk; Risk Factors | 2004 |
Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence.
Topics: Allantoin; Amidohydrolases; Arginine; Cells, Cultured; Cellular Senescence; Chemokine CCL2; Endothelial Cells; Enzyme Inhibitors; Flow Cytometry; Humans; Immunophenotyping; Interleukin-8; Nitric Oxide Synthase; Oxidative Stress; S-Adenosylhomocysteine; Telomerase; Umbilical Veins | 2004 |
Vascular endothelium is the organ chiefly responsible for the catabolism of plasma asymmetric dimethylarginine--an explanation for the elevation of plasma ADMA in disorders characterized by endothelial dysfunction.
Topics: Amidohydrolases; Arginine; Biomarkers; Catalysis; Clinical Trials as Topic; Endothelium, Vascular; Evidence-Based Medicine; Humans; Models, Cardiovascular; Oxidative Stress; Vascular Diseases | 2004 |
Hypercholesterolemia impairs basal nitric oxide synthase turnover rate: a study investigating the conversion of L-[guanidino-(15)N(2)]-arginine to (15)N-labeled nitrate by gas chromatography--mass spectrometry.
Topics: Animals; Arginine; Cholesterol; Cholesterol, Dietary; Diet, Atherogenic; Endothelium, Vascular; Gas Chromatography-Mass Spectrometry; Hypercholesterolemia; Indicator Dilution Techniques; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrogen Isotopes; Rabbits | 2004 |
Plasma asymmetric dimethylarginine and coronary and peripheral endothelial dysfunction in hypertensive patients.
Topics: Aged; Arginine; Coronary Circulation; Echocardiography, Doppler; Endothelium, Vascular; Female; Forearm; Humans; Hypertension; Hypertrophy, Left Ventricular; Insulin Resistance; Male; Middle Aged | 2004 |
Atherosclerosis and uremic retention solutes.
Topics: Arginine; Arteriosclerosis; Female; Glomerulosclerosis, Focal Segmental; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Middle Aged; Nitric Oxide; Oxidative Stress; Phosphates; Uremia | 2004 |
Determination of arginine and asymmetric dimethylarginine (ADMA) in human plasma by liquid chromatography/mass spectrometry with the isotope dilution technique.
Topics: Adult; Aged; Arginine; Calibration; Carbon Isotopes; Chromatography, Liquid; Citrulline; Female; Humans; Indicator Dilution Techniques; Kidney Failure, Chronic; Male; Mass Spectrometry; Middle Aged; Plasma; Sensitivity and Specificity | 2004 |
Endothelial dysfunction in patients with peripheral arterial disease and chronic hyperhomocysteinemia: potential role of ADMA.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Arterial Occlusive Diseases; Chronic Disease; Endothelium, Vascular; Enzyme Inhibitors; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nitric Oxide Synthase; Peripheral Vascular Diseases; Radial Artery; Ultrasonography; Vasodilation | 2004 |
Association between cerebrospinal fluid levels of asymmetric dimethyl-L-arginine, an endogenous inhibitor of endothelial nitric oxide synthase, and cerebral vasospasm in a primate model of subarachnoid hemorrhage.
Topics: Animals; Arginine; Disease Models, Animal; Enzyme Inhibitors; Macaca fascicularis; Middle Cerebral Artery; Nitric Oxide; Nitric Oxide Synthase; Subarachnoid Hemorrhage; Time Factors; Vasospasm, Intracranial | 2004 |
The transplanted liver graft is capable of clearing asymmetric dimethylarginine.
Topics: Acute Disease; Arginine; Biomarkers; Case-Control Studies; Chronic Disease; Graft Rejection; Humans; Kidney; Liver; Liver Failure; Liver Transplantation; Osmolar Concentration; Postoperative Period; Prospective Studies | 2004 |
Relationship between obesity, smoking, and the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine.
Topics: Aged; Arginine; Arteriosclerosis; Coronary Disease; Cross-Sectional Studies; Enzyme Inhibitors; Humans; Insulin Resistance; Male; Metabolic Diseases; Middle Aged; Nitric Oxide Synthase; Obesity; Risk Factors; Smoking | 2004 |
Relationship of asymmetric dimethylarginine to haemodialysis hypotension.
Topics: Aged; Arginine; Female; Humans; Hypotension; Male; Nitrates; Nitrites; Renal Dialysis; Tumor Necrosis Factor-alpha | 2004 |
Aspirin protected against endothelial damage induced by LDL: role of endogenous NO synthase inhibitors in rats.
Topics: Amidohydrolases; Animals; Aorta, Thoracic; Arginine; Aspirin; Dose-Response Relationship, Drug; Endothelium, Vascular; Intercellular Adhesion Molecule-1; Lipoproteins, LDL; Male; Malondialdehyde; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2004 |
Determination of asymmetric dimethylarginine (ADMA) using a novel ELISA assay.
Topics: Animals; Arginine; Cells, Cultured; Coronary Vessels; Culture Media, Conditioned; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Humans; Linear Models; Mice; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase; Rats; Sensitivity and Specificity | 2004 |
Weight loss reduces circulating asymmetrical dimethylarginine concentrations in morbidly obese women.
Topics: Adult; Arginine; Body Mass Index; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Gastroplasty; Humans; Middle Aged; Obesity, Morbid; Osmolar Concentration; Weight Loss | 2004 |
Plasma levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Arginine; Female; Hemoglobin, Sickle; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Vascular Cell Adhesion Molecule-1 | 2005 |
A calcium channel blocker, benidipine, improves cell membrane fluidity in human subjects via a nitric oxide-dependent mechanism. An electron paramagnetic resonance investigation.
Topics: Aged; Arginine; Calcium Channel Blockers; Cell Membrane; Cyclic GMP; Dihydropyridines; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Erythrocytes; Female; Hemorheology; Humans; Male; Membrane Fluidity; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Viscosity | 2004 |
Capillary electrophoretic and micellar electrokinetic separations of asymmetric dimethyl-L-arginine and structurally related amino acids: quantitation in human plasma.
Topics: 4-Chloro-7-nitrobenzofurazan; Arginine; Chromatography, Micellar Electrokinetic Capillary; Electrophoresis, Capillary; Humans | 2004 |
A reduction of endogenous asymmetric dimethylarginine contributes to the effect of captopril on endothelial dysfunction induced by homocysteine in rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Captopril; Creatinine; Dose-Response Relationship, Drug; Endothelium, Vascular; Homocysteine; In Vitro Techniques; Liver; Male; Malondialdehyde; Nitrates; Nitric Oxide Synthase; Nitrites; Peptidyl-Dipeptidase A; Phenylephrine; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Vasoconstriction; Vasodilator Agents | 2005 |
Erythropoietin increases asymmetric dimethylarginine in endothelial cells: role of dimethylarginine dimethylaminohydrolase.
Topics: Amidohydrolases; Antioxidants; Arginine; Cells, Cultured; Darbepoetin alfa; Endothelial Cells; Erythropoietin; Humans; Intracellular Membranes; Nitric Oxide; Oxidative Stress; Pyrrolidines; Recombinant Proteins; Thiocarbamates | 2005 |
Circulating ADMA concentrations are elevated in hypopituitary adults with and without growth hormone deficiency.
Topics: Arginine; Enzyme Inhibitors; Female; Human Growth Hormone; Humans; Hypopituitarism; Male; Middle Aged; Nitric Oxide Synthase | 2005 |
A new method for the liquid chromatography analysis of methylated arginines in biological fluids and tissues by o-phthaldialdehyde postcolumn derivatization.
Topics: Arginine; Chromatography, High Pressure Liquid; Humans; o-Phthalaldehyde; Online Systems | 2005 |
Hyperglycemia, asymmetric dimethylarginine, and patient survival: Dysregulation of complex networks and the metabolic basis of disease.
Topics: Arginine; Critical Illness; Homocysteine; Humans; Insulin; Nitric Oxide Synthase; Signal Transduction; Survival Rate | 2005 |
Plasma asymmetric dimethylarginine concentrations in newly diagnosed patients with acute myocardial infarction or unstable angina pectoris during two weeks of medical treatment.
Topics: Adult; Aged; alpha-Tocopherol; Angina, Unstable; Angioplasty, Balloon, Coronary; Arginine; C-Reactive Protein; Cardiovascular Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Combined Modality Therapy; Coronary Angiography; Coronary Artery Disease; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Insulin; Lipoproteins, HDL; Male; Middle Aged; Myocardial Infarction; Statistics as Topic; Treatment Outcome; Triglycerides | 2005 |
Acute hyperhomocysteinemia decreases NO bioavailability in healthy adults.
Topics: Acute Disease; Animals; Arginine; Biological Availability; Enzyme Inhibitors; Haplorhini; Humans; Hyperhomocysteinemia; Methionine; Nitric Oxide; Oxidative Stress; Reproducibility of Results | 2005 |
Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis.
Topics: Amidohydrolases; Animals; Arginine; Enzyme Induction; Female; Hindlimb; Humans; Ischemia; Laser-Doppler Flowmetry; Mice; Mice, Transgenic; Microspheres; Muscle, Skeletal; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Prostheses and Implants; Recombinant Fusion Proteins | 2005 |
Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension.
Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Humans; Hypertension, Pulmonary; Isoenzymes; Lung; Male; Monocrotaline; Nitric Oxide; Rats; Rats, Sprague-Dawley | 2005 |
Increased circulating concentrations of asymmetric dimethylarginine (ADMA) in white coat hypertension.
Topics: Adult; Arginine; Blood Pressure Monitoring, Ambulatory; Case-Control Studies; Endothelium, Vascular; Female; Humans; Hypertension; Male; Middle Aged; Nitric Oxide; Office Visits | 2005 |
Asymmetrical dimethylarginine plasma concentrations are related to basal nitric oxide release but not endothelium-dependent vasodilation of resistance arteries in peritoneal dialysis patients.
Topics: Arginine; Arteries; Endothelium, Vascular; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Peritoneal Dialysis; Vascular Resistance; Vasodilation | 2005 |
Asymmetrical dimethylarginine in idiopathic pulmonary arterial hypertension.
Topics: Adult; Arginine; Biomarkers; Cardiac Catheterization; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Male; Middle Aged; Nitric Oxide Synthase Type III; Pulmonary Circulation; Stroke Volume; Survival Analysis; Vascular Resistance | 2005 |
Effect of diabetic duration on serum concentrations of endogenous inhibitor of nitric oxide synthase in patients and rats with diabetes.
Topics: Adult; Aged; Animals; Arginine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Streptozocin; Time Factors; Vasoconstriction | 2005 |
Prognostic value of combined use of biomarkers of inflammation, endothelial dysfunction, and myocardiopathy in patients with ESRD.
Topics: Adult; Aged; Arginine; Arteriosclerosis; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Endothelium, Vascular; Female; Heart Failure; Humans; Kidney Failure, Chronic; Male; Middle Aged; Natriuretic Peptide, Brain; Prognosis | 2005 |
ADMA regulates angiogenesis: genetic and metabolic evidence.
Topics: Animals; Arginine; Blotting, Western; Disease Models, Animal; Female; Hypercholesterolemia; Ischemia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neovascularization, Physiologic; Nitric Oxide Synthase | 2005 |
Asymmetric dimethylarginine and progression of chronic kidney disease: the mild to moderate kidney disease study.
Topics: Adult; Arginine; Creatinine; Disease Progression; Female; Glomerular Filtration Rate; Hemoglobins; Humans; Kidney; Kidney Diseases; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Parathyroid Hormone; Proportional Hazards Models; Renal Insufficiency; Treatment Outcome | 2005 |
Relations between plasma asymmetric dimethylarginine (ADMA) and risk factors for coronary disease.
Topics: Adult; Aged; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Coronary Angiography; Coronary Disease; Disease Progression; Female; Follow-Up Studies; Glomerular Filtration Rate; Homocysteine; Humans; Male; Middle Aged; Nitric Oxide Synthase; Prognosis; Retrospective Studies; Risk Factors; Smoking | 2006 |
Asymmetrical dimethylarginine predicts progression to dialysis and death in patients with chronic kidney disease: a competing risks modeling approach.
Topics: Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular System; Cohort Studies; Dialysis; Disease Progression; Enzyme Inhibitors; Follow-Up Studies; Glomerular Filtration Rate; Hemoglobins; Homocysteine; Humans; Inflammation; Kidney Failure, Chronic; Middle Aged; Models, Statistical; Models, Theoretical; Proportional Hazards Models; Proteinuria; Regression Analysis; Risk; Risk Factors; Time Factors; Treatment Outcome | 2005 |
Liquid chromatography-tandem mass spectrometry method for the analysis of asymmetric dimethylarginine in human plasma.
Topics: Arginine; Chromatography, High Pressure Liquid; Humans; Reference Values; Spectrometry, Mass, Electrospray Ionization | 2005 |
Asymmetric dimethylarginine and kidney disease--marker or mediator?
Topics: Animals; Arginine; Biomarkers; Humans; Kidney; Kidney Diseases; Nitric Oxide; Renal Insufficiency; Risk | 2005 |
Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase.
Topics: Amidohydrolases; Animals; Arginine; Cell Line; Cell Survival; In Vitro Techniques; Kidney; Male; Nitric Oxide Synthase; Rats; Rats, Inbred WKY; Structure-Activity Relationship | 2005 |
Endothelial dysfunction induced by postprandial lipemia is neutralized by addition of proteins to the fatty meal.
Topics: Adult; Arginine; Blood Flow Velocity; Brachial Artery; Caseins; Dietary Fats; Dietary Proteins; Endothelium, Vascular; Fatty Acids, Nonesterified; Female; Humans; Insulin; Lipids; Male; Postprandial Period; Soybean Proteins; Triglycerides; Ultrasonography; Vasodilation | 2006 |
Asymmetric dimethyl arginine levels correlate with cardiovascular risk factors in patients with erectile dysfunction.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Arginine; Blood Pressure; C-Reactive Protein; Cardiovascular Diseases; Cholesterol, LDL; E-Selectin; Enzyme Inhibitors; Erectile Dysfunction; Humans; Male; Middle Aged; Nitric Oxide Synthase; Piperazines; Purines; Risk Factors; Sildenafil Citrate; Sulfones | 2006 |
Asymmetric dimethylarginine, L-arginine, and endothelial dysfunction in essential hypertension.
Topics: Acetylcholine; Arginine; Blood Pressure Determination; Case-Control Studies; Chromatography, High Pressure Liquid; Endothelium, Vascular; Female; Humans; Hypertension; Infusions, Intra-Arterial; Male; Nitroprusside; Probability; Reference Values; Sensitivity and Specificity; Severity of Illness Index | 2005 |
Asymmetric dimethylarginine (ADMA) as a risk marker for stroke and TIA in a Swedish population.
Topics: Acute Disease; Aged; Arginine; Biomarkers; Cerebral Hemorrhage; Cerebral Infarction; Enzyme Inhibitors; Female; Glycated Hemoglobin; Humans; Ischemic Attack, Transient; Male; Multivariate Analysis; Nitric Oxide Synthase; Odds Ratio; Risk Factors; Stroke | 2006 |
The effects of thyroxine replacement on the levels of serum asymmetric dimethylarginine (ADMA) and other biochemical cardiovascular risk markers in patients with subclinical hypothyroidism.
Topics: Adolescent; Adult; Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Cholesterol; Enzyme Inhibitors; Female; Homocysteine; Hormone Replacement Therapy; Humans; Hypothyroidism; Lipoproteins, HDL; Lipoproteins, LDL; Middle Aged; Nitric Oxide; Risk Factors; Thyrotropin; Thyroxine; Triiodothyronine | 2005 |
Pioglitazone lowers systemic asymmetric dimethylarginine by inducing dimethylarginine dimethylaminohydrolase in rats.
Topics: Amidohydrolases; Animals; Arginine; Cell Line; Dogs; Enzyme Induction; Gene Expression Regulation, Enzymologic; Homocysteine; Hypoglycemic Agents; Kidney Tubules; Male; Nitric Oxide; Pioglitazone; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Sodium; Thiazolidinediones; Up-Regulation | 2005 |
Asymmetric dimethylarginine and the risk of cardiovascular events and death in patients with coronary artery disease: results from the AtheroGene Study.
Topics: Adult; Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Coronary Disease; Creatinine; Female; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Prospective Studies; Risk Factors | 2005 |
Raised plasma levels of asymmetric dimethylarginine are associated with cardiovascular events, disease activity, and organ damage in patients with systemic lupus erythematosus.
Topics: Adult; Arginine; Biomarkers; Cardiovascular Diseases; Female; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Nitric Oxide Synthase; Regression Analysis; Risk Factors; Severity of Illness Index | 2005 |
Systemic nitric oxide production rate during hemodialysis and its relationship with nitric oxide-related factors.
Topics: Arginine; Biopterins; Blood Pressure; Female; Humans; Lipoproteins, LDL; Male; Middle Aged; Nitrates; Nitric Oxide; Renal Dialysis | 2005 |
Asymmetric dimethylarginine: a molecule responsible for the coexistence of insulin resistance and atherosclerosis via dual nitric oxide synthase inhibition.
Topics: Animals; Arginine; Atherosclerosis; Biomarkers; Enzyme Inhibitors; Evidence-Based Medicine; Humans; Insulin Resistance; Models, Biological; Nitric Oxide; Nitric Oxide Synthase | 2005 |
Dimethylarginine dimethylaminohydrolase overexpression suppresses graft coronary artery disease.
Topics: Amidohydrolases; Animals; Arginine; Coronary Artery Disease; Cytokines; Enzyme Inhibitors; Female; Heart; Heart Transplantation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocarditis; Myocardium; Nitrates; Nitric Oxide Synthase; Nitrites; Osmolar Concentration; Postoperative Period; Pregnancy; Superoxides; Time Factors; Transplantation, Heterotopic; Transplantation, Homologous; Tumor Necrosis Factor-alpha | 2005 |
The GLU298ASP variant of nitric oxide synthase interacts with asymmetric dimethyl arginine in determining cardiovascular mortality in patients with end-stage renal disease.
Topics: Adult; Aged; Amino Acid Substitution; Analysis of Variance; Arginine; Aspartic Acid; Cardiovascular Diseases; Female; Gene Frequency; Genotype; Glutamic Acid; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase; Polymorphism, Genetic; Regression Analysis; Survival Rate | 2005 |
Determination of a reference value for N(G), N(G)-dimethyl-L-arginine in 500 subjects.
Topics: Adult; Aged; Aging; Arginine; Biomarkers; Cardiovascular Diseases; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Reference Values; Sensitivity and Specificity; Sex Characteristics | 2005 |
An association between plasma asymmetric dimethylarginine and membrane fluidity of erythrocytes in hypertensive and normotensive men: an electron paramagnetic resonance investigation.
Topics: Arginine; Electron Spin Resonance Spectroscopy; Erythrocyte Membrane; Humans; Hypertension; Male; Membrane Fluidity; Middle Aged; Nitrates; Nitrites | 2005 |
Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA.
Topics: Arginine; Atherosclerosis; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins; Cardiovascular Diseases; Cell Culture Techniques; Endothelial Cells; Gene Expression Profiling; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Oligonucleotide Array Sequence Analysis; Protein-Arginine N-Methyltransferases; Smad5 Protein; Transforming Growth Factor beta | 2005 |
Concentrations of homocysteine, related metabolites and asymmetric dimethylarginine in preeclamptic women with poor nutritional status.
Topics: Adult; Arginine; Female; Homocysteine; Humans; Nutritional Status; Pre-Eclampsia; Pregnancy; Time Factors; Vitamins | 2005 |
Asymmetric dimethylarginine, homocysteine and renal function--is there a relation?
Topics: Adult; Age Factors; Arginine; Female; Homocysteine; Humans; Hyperhomocysteinemia; Kidney; Kidney Function Tests; Male; Middle Aged; Renal Dialysis | 2005 |
Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation.
Topics: Animals; Antioxidants; Aorta, Thoracic; Arginine; Biopterins; Cells, Cultured; Cystathionine beta-Synthase; Endothelium, Vascular; Enzyme Activation; Female; Gene Expression Regulation, Enzymologic; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Homocysteine; Humans; Hyperhomocysteinemia; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Kinase C; Pterins; Superoxide Dismutase; Vasodilation | 2005 |
[ADMA (asymmetric dimethylarginine)--the inhibitor of nitric oxide (NO) synthesis: a new marker for vascular pathology].
Topics: Arginine; Biomarkers; Humans; Nitric Oxide; Nitric Oxide Synthase; Vascular Diseases; Vasoconstriction | 2005 |
ADMA, endothelial progenitor cells, and cardiovascular risk.
Topics: Arginine; Cardiovascular Diseases; Endothelial Cells; Humans; Risk Factors; Stem Cells | 2005 |
Homocysteine-induced vascular dysregulation is mediated by the NMDA receptor.
Topics: Animals; Aorta, Thoracic; Arginine; Cell Culture Techniques; Cell Movement; Cell Proliferation; Homocysteine; Interleukin-1; Matrix Metalloproteinase 9; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 2005 |
L-NAME- and ADMA-induced sympathetic neural activation in conscious rats.
Topics: Animals; Arginine; Baroreflex; Consciousness; Female; Kidney; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Sinoatrial Node; Sympathectomy; Sympathetic Nervous System | 2006 |
Determination of asymmetric dimethylarginine: liquid chromatography-mass spectrometry or ELISA?
Topics: Arginine; Chromatography, Liquid; Enzyme-Linked Immunosorbent Assay; Humans; Hypercholesterolemia; Hypertriglyceridemia; Kidney Failure, Chronic; Mass Spectrometry | 2005 |
Reduced nitric oxide concentration in the renal cortex of streptozotocin-induced diabetic rats: effects on renal oxygenation and microcirculation.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Kidney Cortex; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Oxygen; Rats; Rats, Inbred WF; Renal Circulation | 2005 |
Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine.
Topics: Arginine; Cell Count; Cells, Cultured; Coronary Artery Disease; Endothelium, Vascular; Enzyme Inhibitors; Humans; Stem Cells | 2005 |
ADMAring Endothelial Progenitor Cells Accident, Association, or Antecedent.
Topics: Arginine; Cell Differentiation; Cell Movement; Endothelium, Vascular; Enzyme Inhibitors; Stem Cells | 2005 |
In vitro and in vivo effects of probucol on hydrolysis of asymmetric dimethyl L-arginine and vasospasm in primates.
Topics: Animals; Antioxidants; Arginine; Bilirubin; Cell Culture Techniques; Double-Blind Method; Endothelial Cells; Enzyme Inhibitors; Hydrolysis; Lipid Peroxidation; Macaca fascicularis; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidation-Reduction; Placebos; Probucol; Random Allocation; Subarachnoid Hemorrhage; Time Factors; Umbilical Veins; Vasospasm, Intracranial | 2005 |
Serum asymmetric dimethylarginine as a marker of coronary microcirculation in patients with non-insulin dependent diabetes mellitus: correlation with coronary flow reserve.
Topics: Aged; Arginine; Biomarkers; Blood Flow Velocity; Coronary Artery Disease; Coronary Circulation; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; Male; Microcirculation; Regression Analysis | 2005 |
Lysophosphatidylcholine-induced elevation of asymmetric dimethylarginine level by the NADPH oxidase pathway in endothelial cells.
Topics: Amidohydrolases; Arginine; Biphenyl Compounds; Cell Line; Cell Survival; Endothelial Cells; Enzyme Inhibitors; Humans; Lysophosphatidylcholines; NADPH Oxidases; Nitric Oxide; Onium Compounds; Protein-Arginine N-Methyltransferases; Reactive Oxygen Species; Repressor Proteins | 2006 |
A role for asymmetric dimethylarginine in the pathophysiology of portal hypertension in rats with biliary cirrhosis.
Topics: Acetylcholine; Animals; Arginine; Hypertension, Portal; Liver; Liver Cirrhosis, Biliary; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Thioacetamide; Vasodilation | 2005 |
A gas, an amino acid, and an imposter: the story of nitric oxide, L-arginine, and ADMA in portal hypertension.
Topics: Animals; Arginine; Hypertension, Portal; Nitric Oxide; Rats | 2005 |
Comparison of HPLC method and commercial ELISA assay for asymmetric dimethylarginine (ADMA) determination in human serum.
Topics: Arginine; Calibration; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Humans | 2006 |
Elevated serum interleukin-18 levels might reflect the high risk of hospitalization in patients on peritoneal dialysis.
Topics: Aged; Arginine; Atherosclerosis; beta 2-Microglobulin; Biomarkers; Female; Hospitalization; Humans; Inflammation Mediators; Interleukin-18; Kidney Failure, Chronic; Male; Peritoneal Dialysis; Risk Factors | 2005 |
Umbilical vein plasma concentrations of asymmetrical dimethylarginine are increased in male but not female neonates delivered preterm: a pilot study.
Topics: Arginine; Blood Circulation; Body Weight; Female; Fetal Blood; Humans; Infant, Newborn; Male; Nitric Oxide Synthase; Pilot Projects; Premature Birth; Sex Characteristics; Time Factors | 2006 |
Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease.
Topics: Aged; Arginine; Atherosclerosis; Carotid Arteries; Carotid Artery Diseases; Female; Gene Frequency; Genotype; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase Type III; Polymorphism, Genetic; Regression Analysis; Tunica Intima; Tunica Media; White People | 2005 |
Elevations of plasma methylarginines in obesity and ageing are related to insulin sensitivity and rates of protein turnover.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arginine; Blood Glucose; Body Composition; Female; Glucose; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Lipids; Male; Metabolic Syndrome; Middle Aged; Obesity; omega-N-Methylarginine; Proteins; Regression Analysis; Sex Characteristics | 2006 |
Treatment with niacin lowers ADMA.
Topics: Adult; Aged; Arginine; Atherosclerosis; Biomarkers; Female; Humans; Hypolipidemic Agents; Male; Middle Aged; Niacin; Nitric Oxide Synthase; Risk Factors; Treatment Outcome | 2006 |
The determinants of endothelial dysfunction in CKD: oxidative stress and asymmetric dimethylarginine.
Topics: Adult; Arginine; Brachial Artery; Cardiovascular Diseases; Chronic Disease; Copper; Endothelium, Vascular; Erythrocytes; Female; Glomerular Filtration Rate; Glutathione Peroxidase; Humans; Kidney Diseases; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Selenium; Severity of Illness Index; Superoxide Dismutase; Vasodilation; Zinc | 2006 |
Accumulation of symmetric dimethylarginine in hepatorenal syndrome.
Topics: Arginine; Case-Control Studies; Creatinine; Fibrosis; Hepatorenal Syndrome; Humans; Kidney; Liver; Male; Middle Aged; Nitric Oxide; Renal Insufficiency | 2006 |
Fast and efficient determination of arginine, symmetric dimethylarginine, and asymmetric dimethylarginine in biological fluids by hydrophilic-interaction liquid chromatography-electrospray tandem mass spectrometry.
Topics: Adult; Arginine; Body Fluids; Cells, Cultured; Chromatography, Liquid; Female; Humans; Male; Middle Aged; Spectrometry, Mass, Electrospray Ionization | 2006 |
Abnormal nitric oxide metabolism in systemic sclerosis: increased levels of nitrated proteins and asymmetric dimethylarginine.
Topics: Adult; Arginine; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Raynaud Disease; Scleroderma, Diffuse; Scleroderma, Limited; Scleroderma, Systemic; Severity of Illness Index | 2006 |
Detection of dimethylarginines in protein hydrolysates by matrix-assisted laser desorption/ionization mass spectrometry.
Topics: Animals; Arginine; Blood Proteins; Collodion; Coumaric Acids; Fish Proteins; Protein Hydrolysates; Protein-Arginine N-Methyltransferases; Repressor Proteins; Saccharomyces cerevisiae Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2006 |
Endurance training reduces circulating asymmetric dimethylarginine and myeloperoxidase levels in persons at risk of coronary events.
Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Cyclic GMP; Exercise; Female; Humans; Male; Middle Aged; Peroxidase; Risk Factors | 2005 |
Asymmetric dimethylarginine is associated with macrovascular disease and total homocysteine in patients with type 2 diabetes.
Topics: Aged; Arginine; Arterial Occlusive Diseases; Biomarkers; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Homocysteine; Humans; Hypoglycemic Agents; Incidence; Male; Middle Aged; Nitric Oxide Synthase; Prognosis; Risk Factors; Severity of Illness Index | 2006 |
Estrogen replacement effectively improves the accelerated intimal hyperplasia following balloon injury of carotid artery in the ovariectomized rats.
Topics: Animals; Arginine; Carotid Arteries; Catheterization; Cyclic GMP; Estradiol; Estrogen Replacement Therapy; Female; Follicle Stimulating Hormone; Hyperplasia; Immunohistochemistry; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Ovariectomy; Rats; Rats, Sprague-Dawley; Tunica Intima; Vasodilation | 2006 |
Coronary endothelial dysfunction is associated with erectile dysfunction and elevated asymmetric dimethylarginine in patients with early atherosclerosis.
Topics: Arginine; C-Reactive Protein; Coronary Artery Disease; Endothelium, Vascular; Erectile Dysfunction; Humans; Male; Middle Aged; Risk Factors | 2006 |
ADMA: an emerging cardiovascular risk factor.
Topics: Animals; Arginine; Cardiovascular Physiological Phenomena; Humans; Nitric Oxide Synthase | 2005 |
Asymmetric dimethylarginine (ADMA) accelerates cell senescence.
Topics: Amidohydrolases; Arginine; Cells, Cultured; Cellular Senescence; Chemokine CCL2; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Humans; Interleukin-8; Nitric Oxide Synthase; Oxidative Stress; Reactive Oxygen Species; S-Adenosylhomocysteine; Telomerase | 2005 |
ADMA and oxidative stress may relate to the progression of renal disease: rationale and design of the VIVALDI study.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Arginine; Benzimidazoles; Benzoates; Clinical Protocols; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dinoprost; Endothelium, Vascular; Humans; Hypertension; Middle Aged; Multicenter Studies as Topic; Oxidative Stress; Randomized Controlled Trials as Topic; Renal Insufficiency; Telmisartan; Tetrazoles; Valine; Valsartan | 2005 |
Effect of vasoconstrictor coupling factor 6 on gene expression profile in human vascular endothelial cells: enhanced release of asymmetric dimethylarginine.
Topics: Amidohydrolases; Arginine; Blotting, Western; Cells, Cultured; Endothelial Cells; Gene Expression Profiling; Humans; Mitochondrial Proton-Translocating ATPases; Nitric Oxide Synthase; Oligonucleotide Array Sequence Analysis; Oxidative Phosphorylation Coupling Factors; Protein-Arginine N-Methyltransferases; Umbilical Veins | 2006 |
Asymmetric arginine dimethylation of heterogeneous nuclear ribonucleoprotein K by protein-arginine methyltransferase 1 inhibits its interaction with c-Src.
Topics: Amino Acid Sequence; Arginine; CSK Tyrosine-Protein Kinase; DNA Methylation; Dose-Response Relationship, Drug; Embryo, Mammalian; Ethanolamines; HeLa Cells; Heterogeneous-Nuclear Ribonucleoprotein K; Humans; Mass Spectrometry; Methylation; Microscopy, Fluorescence; Molecular Sequence Data; Phosphorylation; Plasmids; Protein Binding; Protein Biosynthesis; Protein Interaction Mapping; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein-Arginine N-Methyltransferases; Protein-Tyrosine Kinases; Recombinant Proteins; Repressor Proteins; RNA; Sepharose; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; src-Family Kinases; Stem Cells; Transcription, Genetic; Transfection | 2006 |
Asymmetric dimethylarginine induces apoptosis via p38 MAPK/caspase-3-dependent signaling pathway in endothelial cells.
Topics: Apoptosis; Arginine; Caspase 3; Caspases; Cells, Cultured; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; MAP Kinase Signaling System; Nitric Oxide Synthase Type III; p38 Mitogen-Activated Protein Kinases; Pyridines; Umbilical Veins | 2006 |
Dimethylarginine dimethylaminohydrolase inhibition and asymmetric dimethylarginine accumulation contribute to endothelial dysfunction in rats exposed to glycosylated protein: effects of aminoguanidine.
Topics: Amidohydrolases; Animals; Antioxidants; Aorta; Arginine; Blood Proteins; Endothelium, Vascular; Enzyme Inhibitors; Glycosylation; Guanidines; Lipid Peroxidation; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Vasodilation | 2007 |
[Protective effect of losartan on injury induced by ox-LDL in endothelial cells and the relationship with asymmetric dimethylarginine].
Topics: Amidohydrolases; Arginine; Cells, Cultured; Endothelium, Vascular; Humans; L-Lactate Dehydrogenase; Lipoproteins, LDL; Losartan; Nitric Oxide; Protective Agents; Umbilical Veins | 2006 |
Asymmetric dimethylarginine in homocystinuria due to cystathionine beta-synthase deficiency: relevance of renal function.
Topics: Adult; Arginine; Creatinine; Cystathionine beta-Synthase; Cystatin C; Cystatins; Female; Homocysteine; Homocystinuria; Humans; Kidney; Male; Middle Aged; Nitrates; Nitrites; Pyridoxine; Renal Insufficiency | 2006 |
Analysis of asymmetric dimethylarginine in plasma by HPLC using a monolithic column.
Topics: Arginine; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results | 2006 |
Plasma asymmetric dimethylarginine (ADMA), nitrate and the indices of low-density lipoprotein oxidation.
Topics: Adult; Aged; Arginine; Atherosclerosis; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lipid Metabolism; Lipid Peroxidation; Lipoproteins, LDL; Male; Mass Spectrometry; Middle Aged; Nitrates; Nitric Oxide; Risk Factors | 2006 |
Intensive treatment of risk factors in patients with type-2 diabetes mellitus is associated with improvement of endothelial function coupled with a reduction in the levels of plasma asymmetric dimethylarginine and endogenous inhibitor of nitric oxide synt
Topics: Arginine; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Female; Humans; Hyperglycemia; Male; Middle Aged; Nitric Oxide Synthase; Risk Factors; Tumor Necrosis Factor-alpha | 2006 |
Urotensin II and biomarkers of endothelial activation and atherosclerosis in end-stage renal disease.
Topics: Arginine; Atherosclerosis; Biomarkers; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Immunoenzyme Techniques; Intercellular Adhesion Molecule-1; Kidney Failure, Chronic; Male; Middle Aged; Regression Analysis; Risk Factors; Urotensins | 2006 |
Plasma levels of asymmetric dimethylarginine (ADMA) are related to intima-media thickness of the carotid artery: an epidemiological study.
Topics: Aged; Arginine; Blood Pressure; Carotid Arteries; Female; Humans; Japan; Male; Middle Aged; Multivariate Analysis; Tunica Intima; Ultrasonography | 2007 |
Effect of L-arginine on asymmetric dimethylarginine (ADMA) or homocysteine-accelerated endothelial cell aging.
Topics: Aging; Arginine; Cells, Cultured; Cellular Senescence; Endothelial Cells; Endothelium, Vascular; Homocysteine; Humans; NG-Nitroarginine Methyl Ester; Oxidative Stress; Telomerase; Time Factors | 2006 |
L-arginine chlorination results in the formation of a nonselective nitric-oxide synthase inhibitor.
Topics: Animals; Arginine; Cyclic GMP; Enzyme Inhibitors; Hypochlorous Acid; Male; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilation | 2006 |
Evidence for associations between common polymorphisms of estrogen receptor beta gene with homocysteine and nitric oxide.
Topics: Aged; Arginine; Body Mass Index; Cardiovascular Diseases; Cross-Sectional Studies; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Folic Acid; Genetic Variation; Genotype; Homocysteine; Humans; Linkage Disequilibrium; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Polymorphism, Single Nucleotide; Postmenopause; Risk Factors; Vitamin B 12 | 2006 |
Determination of NG,NG-dimethyl-L-arginine in rat plasma and dimethylarginine dimethylaminohydrolase activity in rat kidney using a monolithic silica column.
Topics: Amidohydrolases; Animals; Arginine; Chromatography, High Pressure Liquid; Kidney; Male; Rats; Rats, Sprague-Dawley; Silicon Dioxide | 2006 |
Adverse effects of cigarette smoke on NO bioavailability: role of arginine metabolism and oxidative stress.
Topics: Adult; Animals; Antioxidants; Arginine; Biological Availability; Biological Transport; Cationic Amino Acid Transporter 1; Cattle; Cells, Cultured; Citrulline; Cotinine; Culture Media; Endothelial Cells; Enzyme Activation; Humans; Male; Nicotiana; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Oxidative Stress; Reactive Oxygen Species; Smoke; Smoking | 2006 |
Molecular mechanism for elevation of asymmetric dimethylarginine and its role for hypertension in chronic kidney disease.
Topics: Adenoviridae; Amidohydrolases; Animals; Arginine; Cholesterol; Hypertension; Kidney; Kidney Failure, Chronic; Kinetics; Liver; Male; Nephrectomy; Protein-Arginine N-Methyltransferases; Rats; Rats, Sprague-Dawley; Time Factors | 2006 |
ADMA, proteinuria, and insulin resistance in non-diabetic stage I chronic kidney disease.
Topics: Adult; Arginine; Biomarkers; C-Reactive Protein; Case-Control Studies; Chronic Disease; Disease Progression; Female; Homeostasis; Humans; Insulin; Insulin Resistance; Kidney Diseases; Male; Proteinuria; Regression Analysis | 2006 |
Asymmetrical dimethylarginine (ADMA) and coronary endothelial function in patients with coronary artery disease and mild hypercholesterolemia.
Topics: Acetylcholine; Adenosine; Aged; Arginine; Coronary Artery Disease; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Nitroglycerin; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2007 |
Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of ADMA.
Topics: Adult; Amidohydrolases; Animals; Arginine; Bronchoalveolar Lavage Fluid; Cardiovascular System; Female; Humans; In Vitro Techniques; Kidney; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Myocardium; Nitric Oxide; Protein-Arginine N-Methyltransferases | 2007 |
Letter by Kielstein et al regarding article, "Renal function as a predictor of outcome in a broad spectrum of patients with heart failure".
Topics: Angiotensin-Converting Enzyme Inhibitors; Arginine; Cardiac Output, Low; Creatinine; Disease Progression; Glomerular Filtration Rate; Humans; Kidney; Kidney Failure, Chronic; Predictive Value of Tests; Risk Factors | 2006 |
Probucol decreases asymmetrical dimethylarginine level by alternation of protein arginine methyltransferase I and dimethylarginine dimethylaminohydrolase activity.
Topics: Amidohydrolases; Antioxidants; Arginine; Cell Line; Endothelial Cells; Humans; L-Lactate Dehydrogenase; Lipoproteins, LDL; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type III; Probucol; Protein-Arginine N-Methyltransferases | 2006 |
Epigallocatechin gallate preserves endothelial function by reducing the endogenous nitric oxide synthase inhibitor level.
Topics: Animals; Arginine; Catechin; Cells, Cultured; Cholesterol, LDL; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Male; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Vasodilation | 2006 |
Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study.
Topics: Aged; Arginine; Case-Control Studies; Coronary Disease; Female; Humans; Male; Middle Aged; Risk Factors | 2006 |
Cigarettes and ADMA: the smoke hasn't cleared yet.
Topics: Arginine; Endothelial Cells; Humans; Nicotiana; Nitric Oxide Synthase; Osmolar Concentration; Smoke | 2006 |
Proceedings of the 2nd International Symposium on ADMA -- An Emerging Cardiovascular Risk Factor, November 6, 2004, New Orleans, Louisiana, USA.
Topics: Animals; Arginine; Cardiovascular Physiological Phenomena; Humans; Nitric Oxide Synthase | 2005 |
Gene polymorphism and requirement for vasopressor infusion after cardiac surgery.
Topics: Adaptor Proteins, Signal Transducing; Aged; Alleles; Amidohydrolases; Arginine; Cardiac Surgical Procedures; Casein Kinase II; Cohort Studies; Comorbidity; Elective Surgical Procedures; Epinephrine; Female; Genetic Predisposition to Disease; Genotype; Histocompatibility Antigens Class II; Humans; Inflammation; Lymphotoxin-alpha; Major Histocompatibility Complex; Male; Middle Aged; Norepinephrine; Polymorphism, Single Nucleotide; Postoperative Complications; Tumor Necrosis Factor-alpha; Vascular Resistance; Vasoconstrictor Agents; Vasodilation | 2006 |
Asymmetric dimethylarginine predicts major adverse cardiovascular events in patients with advanced peripheral artery disease.
Topics: Aged; Arginine; Arteries; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Cohort Studies; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Osmolar Concentration; Peripheral Vascular Diseases; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Severity of Illness Index | 2006 |
Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression.
Topics: Adolescent; Adult; Aged; Aging; Amidohydrolases; Arginine; Biological Availability; Brachial Artery; Carotid Arteries; Endothelium, Vascular; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Regional Blood Flow; Vasodilation | 2007 |
Involvement of DDAH/ADMA/NOS pathway in nicotine-induced endothelial dysfunction.
Topics: Amidohydrolases; Animals; Arginine; Calcium; Endothelium, Vascular; Humans; Male; Nicotine; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; RNA, Messenger; Vascular Diseases | 2006 |
Salt loading on plasma asymmetrical dimethylarginine and the protective role of potassium supplement in normotensive salt-sensitive asians.
Topics: Adult; Arginine; Asian People; Blood Pressure; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Osmolar Concentration; Potassium, Dietary; Reference Values; Sodium Chloride, Dietary | 2006 |
Elevated plasma asymmetric dimethyl-L-arginine in a patient with Gordon syndrome.
Topics: Arginine; Diagnosis, Differential; Electrolytes; Female; Humans; Hyperkalemia; Hypertension; Middle Aged; Nitric Oxide; Pseudohypoaldosteronism; Syndrome | 2007 |
Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study.
Topics: Alleles; Amidohydrolases; Arginine; Female; Genetic Variation; Humans; Male; Polymorphism, Genetic; Prospective Studies; Shock, Septic | 2006 |
Accurate quantification of dimethylamine (DMA) in human urine by gas chromatography-mass spectrometry as pentafluorobenzamide derivative: evaluation of the relationship between DMA and its precursor asymmetric dimethylarginine (ADMA) in health and disease
Topics: Acetazolamide; Adult; Arginine; Benzamides; Circadian Rhythm; Coronary Artery Disease; Dimethylamines; Diuretics; Female; Gas Chromatography-Mass Spectrometry; Health; Humans; Liver Diseases; Male; Middle Aged; Quality Control; Time Factors; Urinalysis | 2007 |
Asymmetric dimethylarginine (ADMA) and hyperhomocysteinemia in patients with acute myocardial infarction.
Topics: Aged; Arginine; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Myocardial Infarction; Regression Analysis; Risk Factors; Statistics, Nonparametric; Stereoisomerism | 2007 |
Asymmetric dimethylarginine is not elevated in exfoliation syndrome but symmetric dimethylarginine is related to exfoliative glaucoma.
Topics: Aged; Arginine; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Exfoliation Syndrome; Female; Glaucoma; Homocysteine; Humans; Male; Oxidative Stress; Prospective Studies | 2007 |
Asymmetric dimethylarginine and cerebrovascular disorders in humans.
Topics: Arginine; Cerebrovascular Disorders; Humans; Nitric Oxide Synthase | 2006 |
Plasma asymmetric dimethylarginine level and extent of lesion at coronary angiography.
Topics: Adolescent; Adult; Aged; Angina Pectoris; Arginine; Coronary Angiography; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Risk; Severity of Illness Index | 2006 |
Association of homocysteine and asymmetric dimethylarginine with atherosclerosis and cardiovascular events in maintenance hemodialysis patients.
Topics: Arginine; Atherosclerosis; Cardiovascular Diseases; Comorbidity; Female; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase; Proportional Hazards Models; Regression Analysis; Renal Dialysis; Risk Factors | 2006 |
Medium-term methionine supplementation increases plasma homocysteine but not ADMA and improves blood pressure control in rats fed a diet rich in protein and adequate in folate and choline.
Topics: Adaptation, Physiological; Animals; Area Under Curve; Arginine; Blood Pressure; Choline; Dietary Proteins; Dietary Supplements; Folic Acid; Homocysteine; Male; Methionine; Methylation; Nitric Oxide; Random Allocation; Rats; Rats, Wistar; Time Factors | 2006 |
Level of asymmetric dimethylarginine and carotid atherosclerosis in patients with chronic kidney disease.
Topics: Adult; Arginine; Carotid Artery Diseases; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase; Renal Dialysis | 2006 |
[Effect of asymmetric dimethylarginine on platelet-aggregation and losartan intervention in spontaneous hypertensive rat models].
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Arginine; Hypertension; Losartan; Male; Platelet Aggregation; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2006 |
Farnesoid X receptor agonist reduces serum asymmetric dimethylarginine levels through hepatic dimethylarginine dimethylaminohydrolase-1 gene regulation.
Topics: Amidohydrolases; Animals; Arginine; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Humans; Isoxazoles; Liver; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2006 |
Vaso-occlusion in Schimke-immuno-osseous dysplasia: is the NO pathway involved?
Topics: Adolescent; Adult; Arginine; Arterial Occlusive Diseases; Atherosclerosis; Child; Child, Preschool; Female; Glomerulosclerosis, Focal Segmental; Humans; Male; Nephrotic Syndrome; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Osteochondrodysplasias | 2006 |
Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function.
Topics: Animals; Aorta; Arginine; Carotid Artery Injuries; Catheterization; Cattle; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Kinetics; Male; Methylation; Nitric Oxide; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Rats; Rats, Wistar; Vasodilation | 2007 |
Effects of breed, gender, exercise and white-coat effect on markers of endothelial function in dogs.
Topics: Alaska; Animals; Arginine; Biomarkers; Color; Dogs; Endothelium; Enzyme Inhibitors; Female; Gene Expression Regulation; Hair; Male; Nitric Oxide; Physical Conditioning, Animal; Sex Characteristics; von Willebrand Factor | 2007 |
Live and let die: asymmetric dimethylarginine and septic shock.
Topics: Arginine; Critical Illness; Humans; Nitric Oxide; Nitric Oxide Synthase; Shock, Septic | 2006 |
Asymmetric dimethylarginine reduced erythrocyte deformability in streptozotocin-induced diabetic rats.
Topics: Animals; Aorta, Thoracic; Arginine; Diabetes Mellitus, Experimental; Endothelium, Vascular; Erythrocyte Deformability; In Vitro Techniques; Male; Malondialdehyde; Nitric Oxide; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Vitamin E | 2007 |
Asymmetric dimethylarginine and nitric oxide levels as signs of endothelial dysfunction in Behcet's disease.
Topics: Adult; Arginine; Behcet Syndrome; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Vasculitis | 2006 |
Insulin and adiponectin inhibit the TNFalpha-induced ADMA accumulation in human endothelial cells: the role of DDAH.
Topics: Adiponectin; Amidohydrolases; Arginine; Cells, Cultured; Coronary Vessels; Endothelial Cells; Humans; Insulin; Tumor Necrosis Factor-alpha; Umbilical Veins | 2007 |
Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine in citrullinemia.
Topics: Arginine; Citrullinemia; Enzyme Inhibitors; Humans; Nitric Oxide; Nitric Oxide Synthase | 2006 |
Asymmetric dimethylarginine induces oxidative and nitrosative stress in murine lung epithelial cells.
Topics: Animals; Arginine; Cell Line; Epithelial Cells; Ethidium; Fluorescence; Interferon-gamma; Lipopolysaccharides; Lung; Mice; Models, Biological; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Nitrosation; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Rhodamines; Superoxides; Tumor Necrosis Factor-alpha | 2007 |
Nontraditional atherosclerotic risk factors and extent of coronary atherosclerosis in patients with combined impaired fasting glucose and impaired glucose tolerance.
Topics: Adult; Aged; Arginine; Blood Glucose; C-Reactive Protein; Cholesterol; Coronary Artery Disease; Discriminant Analysis; Female; Glucose Clamp Technique; Homocysteine; Humans; Insulin Resistance; Male; Middle Aged; Risk Factors; Triglycerides | 2007 |
Asymmetric dimethyl-arginine (ADMA) response to inflammation in acute infections.
Topics: Acute Disease; Arginine; Bacterial Infections; Biomarkers; Blood Pressure; C-Reactive Protein; Calcitonin; Calcitonin Gene-Related Peptide; Chromatography, High Pressure Liquid; Creatinine; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Glycoproteins; Humans; Inflammation; Interleukin-6; Male; Middle Aged; Nitric Oxide Synthase; Protein Precursors; Severity of Illness Index; Tyrosine | 2007 |
Asymmetric dimethylarginine, cortisol/cortisone ratio, and C-peptide: markers for diabetes and cardiovascular risk?
Topics: Arginine; Biomarkers; Blood Glucose; C-Peptide; Case-Control Studies; Coronary Disease; Cortisone; Diabetes Mellitus; Female; Humans; Hydrocortisone; Hyperinsulinism; Logistic Models; Male; Middle Aged; Myocardial Infarction; Nitric Oxide Synthase; Predictive Value of Tests; Risk Assessment | 2007 |
Asymmetrical dimethylarginine independently predicts total and cardiovascular mortality in individuals with angiographic coronary artery disease (the Ludwigshafen Risk and Cardiovascular Health study).
Topics: Analysis of Variance; Arginine; Biomarkers; Cardiovascular Diseases; Coronary Angiography; Coronary Disease; Female; Humans; Male; Middle Aged; Mortality; Predictive Value of Tests; Regression Analysis; Risk Factors | 2007 |
Increasing dimethylarginine levels are associated with adverse clinical outcome in severe alcoholic hepatitis.
Topics: Adult; Aged; Amidohydrolases; Arginine; Biomarkers; Case-Control Studies; Female; Gene Expression Regulation; Hepatitis, Alcoholic; Humans; Hypertension, Portal; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Predictive Value of Tests; Prognosis; Protein-Arginine N-Methyltransferases; Repressor Proteins; Sensitivity and Specificity; Survival Rate | 2007 |
High-throughput liquid chromatographic-tandem mass spectrometric determination of arginine and dimethylated arginine derivatives in human and mouse plasma.
Topics: Analytic Sample Preparation Methods; Animals; Arginine; Chromatography, Liquid; Humans; Mice; Mice, Inbred C57BL; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2007 |
Asymmetric dimethylarginine in cerebral small vessel disease.
Topics: Aged; Arginine; Cerebrovascular Circulation; Cerebrovascular Disorders; Female; Humans; Leukoaraiosis; Male; Microcirculation; Middle Aged | 2007 |
[Effect of puerarin on ADMA-DDAH system in human umbilical vein endothelial cells cultured with oxidized free radical].
Topics: Amidohydrolases; Arginine; Blotting, Western; Cells, Cultured; Culture Media; Endothelial Cells; Endothelins; Free Radicals; Humans; Isoflavones; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Umbilical Veins | 2006 |
Increased plasma levels of asymmetric dimethylarginine in patients with carotid stenosis: no evidence for the role of the common FABP2 A54T gene polymorphism.
Topics: Aged; Arginine; Carotid Artery, Internal; Carotid Stenosis; Case-Control Studies; Fatty Acid-Binding Proteins; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Ultrasonography | 2007 |
Plasma concentrations of asymmetric dimethylarginine (ADMA) in metabolic syndrome.
Topics: Adolescent; Adult; Arginine; C-Reactive Protein; Colombia; Humans; Insulin Resistance; Male; Metabolic Syndrome; White People | 2007 |
Asymmetrical dimethylarginine inhibits shear stress-induced nitric oxide release and dilation and elicits superoxide-mediated increase in arteriolar tone.
Topics: Animals; Arginine; Arterioles; Enzyme Inhibitors; Male; Models, Animal; Muscle, Skeletal; Nitric Oxide; Rats; Rats, Wistar; Shear Strength; Stress, Mechanical; Superoxides; Vascular Resistance; Vasoconstriction; Vasodilation | 2007 |
Asymmetric dimethylarginine (ADMA) induces vascular endothelium impairment and aggravates post-ischemic ventricular dysfunction in rats.
Topics: Acetylcholine; Angiotensin II; Animals; Aorta; Arginine; Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Heart Rate; Male; Myocardial Reperfusion Injury; Nitrates; Nitrites; Perfusion; Rats; Rats, Wistar; RNA, Messenger; Vasoconstrictor Agents; Vasodilator Agents; Ventricular Dysfunction | 2007 |
Should we measure asymmetric dimethylarginine in patients with coronary artery disease?
Topics: Arginine; Biomarkers; Cardiovascular Diseases; Coronary Artery Disease; Humans; Mortality; Predictive Value of Tests; Risk Factors | 2007 |
Asymmetric dimethylarginine and reduced nitric oxide bioavailability in young Black African men.
Topics: Adult; Arginine; Biological Availability; Black People; Brachial Artery; Endothelium, Vascular; Enzyme Inhibitors; Humans; Male; Nitric Oxide; Regional Blood Flow; Regression Analysis; Single-Blind Method; Ultrasonography; Vasodilation; White People | 2007 |
[Dimethylarginine dimethylaminohydrolase and endothelium dysfunction].
Topics: Amidohydrolases; Animals; Arginine; Endothelium, Vascular; Humans; Vascular Diseases | 2006 |
[The influence of tobacco smoke on plasma atherogenic compounds levels in active smokers (preliminary report)].
Topics: Adult; Arginine; Chromatography, High Pressure Liquid; Cotinine; Homocystine; Humans; Male; Middle Aged; Smoking | 2006 |
Dimethylarginines at the crossroad of insulin resistance and atherosclerosis.
Topics: Adult; Arginine; Atherosclerosis; Female; Humans; Insulin Resistance; Male; Middle Aged | 2007 |
Taurine protects against low-density lipoprotein-induced endothelial dysfunction by the DDAH/ADMA pathway.
Topics: Acetylcholine; Amidohydrolases; Animals; Arginine; Cardiovascular Agents; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Humans; Lipoproteins, LDL; Male; Malondialdehyde; Nitric Oxide; Rats; Rats, Sprague-Dawley; Taurine; Time Factors; Tumor Necrosis Factor-alpha; Vasodilation; Vasodilator Agents; Vitamin E | 2007 |
A stable-isotope based technique for the determination of dimethylarginine dimethylaminohydrolase (DDAH) activity in mouse tissue.
Topics: Amidohydrolases; Animals; Arginine; Chromatography, High Pressure Liquid; Isotope Labeling; Kidney; Liver; Mice; Mice, Inbred C57BL; Reproducibility of Results; Tandem Mass Spectrometry | 2007 |
Asymmetric dimethylarginine, smoking, and risk of coronary heart disease in apparently healthy men: prospective analysis from the population-based Monitoring of Trends and Determinants in Cardiovascular Disease/Kooperative Gesundheitsforschung in der Regi
Topics: Adult; Aged; Arginine; Case-Control Studies; Cell Line; Coronary Disease; Endothelium, Vascular; Female; Humans; Male; Mass Screening; Middle Aged; Nitric Oxide Synthase; Plasma; Prospective Studies; Risk; Smoking | 2007 |
Arterial wave reflections and determinants of endothelial function a hypothesis based on peripheral mode of action.
Topics: Age Factors; Aged; Aorta; Arginine; Blood Flow Velocity; Blood Pressure; Coronary Artery Disease; Cross-Sectional Studies; Elasticity; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Humans; Linear Models; Male; Manometry; Middle Aged; Predictive Value of Tests; Prospective Studies; Pulsatile Flow; Radial Artery | 2007 |
The ADMA/DDAH pathway is a critical regulator of endothelial cell motility.
Topics: Actin Cytoskeleton; Amidohydrolases; Animals; Arginine; cdc42 GTP-Binding Protein; Cell Movement; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytoskeleton; Endothelial Cells; Enzyme Activation; Focal Adhesions; Lung; Mice; Mice, Knockout; Neovascularization, Physiologic; rac1 GTP-Binding Protein; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; Signal Transduction; Stress Fibers; Swine | 2007 |
Elevated plasma asymmetric dimethyl-L-arginine levels are linked to endothelial progenitor cell depletion and carotid atherosclerosis in rheumatoid arthritis.
Topics: Adult; Arginine; Arthritis, Rheumatoid; Carotid Arteries; Carotid Artery Diseases; Case-Control Studies; Cell Count; Endothelial Cells; Female; Humans; Male; Mesenchymal Stem Cells; Middle Aged; Nitric Oxide; Ultrasonography | 2007 |
Dimethylarginine dimethylaminohydrolase promotes endothelial repair after vascular injury.
Topics: Amidohydrolases; Animals; Arginine; Cell Proliferation; Disease Models, Animal; Endothelium, Vascular; Enzyme Induction; Femoral Artery; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neovascularization, Physiologic; Nitric Oxide; Probability; Random Allocation; Sensitivity and Specificity; Species Specificity; Vascular Diseases | 2007 |
ADMA is independently related to flow-mediated vasodilation in subjects at low cardiovascular risk.
Topics: Adult; Aged; Analysis of Variance; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Female; Humans; Insulin; Male; Middle Aged; Risk Factors; Vasodilation | 2007 |
Asymmetric dimethylarginine (ADMA) in the aqueous humor of diabetic patients.
Topics: Aged; Aqueous Humor; Arginine; Cataract; Cataract Extraction; Diabetes Complications; Diabetes Mellitus; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Nitrates; Nitrites | 2007 |
Serum asymmetric dimethylarginine negatively correlates with intima-media thickness in early-onset atherosclerosis.
Topics: Age of Onset; Arginine; Atherosclerosis; Biomarkers; Carotid Artery, Internal; Carotid Stenosis; Case-Control Studies; Female; Humans; Inflammation; Linear Models; Male; Middle Aged; Nitric Oxide Synthase; Severity of Illness Index; Tunica Intima; Tunica Media; Ultrasonography | 2007 |
Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease.
Topics: Amidohydrolases; Animals; Arginine; Capillaries; Chronic Disease; Disease Models, Animal; Disease Progression; Fibrosis; Gene Expression Regulation, Enzymologic; Genetic Therapy; Kidney; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta | 2007 |
Oral administration of both tetrahydrobiopterin and L-arginine prevents endothelial dysfunction in rats with chronic renal failure.
Topics: Acetylcholine; Administration, Oral; Animals; Aorta; Arginine; Biopterins; Blood Pressure; Calcimycin; Drug Synergism; Drug Therapy, Combination; Endothelium, Vascular; Kidney Failure, Chronic; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxides | 2007 |
A new perspective for the treatment of renal diseases?
Topics: Amidohydrolases; Arginine; Cardiovascular Diseases; Chronic Disease; Humans; Kidney Diseases; Nitric Oxide Synthase; Risk Factors | 2007 |
Asymmetric dimethyl-arginine and coronary artery calcification in young adults entering middle age: the CARDIA Study.
Topics: Adult; Analysis of Variance; Arginine; Biomarkers; Calcinosis; Case-Control Studies; Coronary Artery Disease; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Humans; Linear Models; Logistic Models; Male; Middle Aged; Research Design; Risk Factors; Tomography, X-Ray Computed; Treatment Outcome | 2007 |
Asymmetric dimethylarginine predicts cardiovascular events in patients with type 2 diabetes.
Topics: Aged; Arginine; C-Reactive Protein; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Middle Aged; Predictive Value of Tests; Prospective Studies; Risk Assessment | 2007 |
Biological variation of asymmetric dimethylarginine and related arginine metabolites and analytical performance goals for their measurement in human plasma.
Topics: Adult; Arginine; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Female; Humans; Male; Middle Aged; Reference Standards; Reproducibility of Results | 2007 |
The inhibitory effect of simvastatin on the ADMA-induced inflammatory reaction is mediated by MAPK pathways in endothelial cells.
Topics: Arginine; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intercellular Adhesion Molecule-1; MAP Kinase Signaling System; NF-kappa B; Nitric Oxide Synthase; Phosphorylation; Protein Kinase Inhibitors; Signal Transduction; Simvastatin; Tumor Necrosis Factor-alpha | 2007 |
Serum leptin, oxidized low density lipoprotein and plasma asymmetric dimethylarginine levels and their relationship with dyslipidaemia in adolescent girls with polycystic ovary syndrome.
Topics: Adolescent; Apolipoproteins B; Arginine; Biomarkers; Case-Control Studies; Cholesterol; Cholesterol, LDL; Dyslipidemias; Female; Humans; Leptin; Lipoprotein(a); Lipoproteins, LDL; Lipoproteins, VLDL; Multivariate Analysis; Obesity; Polycystic Ovary Syndrome; Triglycerides | 2007 |
Regulation by DDAH/ADMA pathway of lipopolysaccharide-induced tissue factor expression in endothelial cells.
Topics: Amidohydrolases; Arginine; Base Sequence; Cells, Cultured; DNA Primers; Endothelial Cells; Gene Expression; Humans; Lipopolysaccharides; NF-kappa B; Reactive Oxygen Species; RNA, Messenger; Thromboplastin | 2007 |
Flow- and acetylcholine-induced dilatation in small arteries from rats with renovascular hypertension--effect of tempol treatment.
Topics: Acetylcholine; Animals; Antioxidants; Arginine; Blood Pressure; Coronary Vessels; Cyclic N-Oxides; Hypertension, Renovascular; Male; Mesenteric Arteries; NADPH Oxidases; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Renal Circulation; S-Nitroso-N-Acetylpenicillamine; Spin Labels; Superoxides; Vasodilation; Vasodilator Agents | 2007 |
High-throughput CZE-UV determination of arginine and dimethylated arginines in human plasma.
Topics: Arginine; Electrophoresis, Capillary; Homoarginine; Humans; Plasma; Spectrophotometry, Ultraviolet | 2007 |
Asymmetric dimethylarginine levels in thyroid diseases.
Topics: Adult; Arginine; Biomarkers; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Thyroid Diseases | 2007 |
Asymmetric dimethylarginine and hypertension in cerebral small vessel disease.
Topics: Arginine; Blood Pressure; Cerebrovascular Disorders; Enzyme Inhibitors; Humans; Hypertension; Leukoaraiosis; Nitric Oxide; Nitric Oxide Synthase | 2007 |
Increased asymmetric dimethylarginine concentrations in stimulated peripheral blood mononuclear cells.
Topics: Arginine; Atorvastatin; Cells, Cultured; Concanavalin A; Enzyme Inhibitors; Heptanoic Acids; Humans; Leukocytes, Mononuclear; Mitogens; Nitric Oxide; Nitric Oxide Synthase; Phytohemagglutinins; Pyrroles; Salicylic Acid | 2007 |
Effects of atorvastatin therapy on hypercholesterolemic rabbits with respect to oxidative stress, nitric oxide pathway and homocysteine.
Topics: Animals; Arginine; Aryldialkylphosphatase; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Diet; Heptanoic Acids; Homocysteine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipid Peroxidation; Male; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Pyrroles; Rabbits; Thiobarbituric Acid Reactive Substances; Triglycerides | 2007 |
ADMA correlates with portal pressure in patients with compensated cirrhosis.
Topics: Adult; Aged; Arginine; Case-Control Studies; Female; Hepatitis C, Chronic; Humans; Hypertension, Portal; Liver Cirrhosis; Male; Middle Aged; Nitric Oxide; Portal Pressure | 2007 |
Role of asymmetric dimethylarginine in inflammatory reactions by angiotensin II.
Topics: Amidohydrolases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Arginine; Cell Adhesion; Cells, Cultured; Culture Media, Conditioned; Endothelial Cells; Endothelium, Vascular; Gene Expression Regulation; Humans; Interleukin-8; Losartan; Monocytes; NF-kappa B; Nitrates; Nitric Oxide; Nitrites; Protein-Arginine N-Methyltransferases; Reactive Oxygen Species; Receptors, Interleukin-8B; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha; Umbilical Veins; Vasculitis; Vasodilation | 2007 |
Asymmetric dimethyl L-arginine (ADMA) is a critical regulator of myocardial reperfusion injury.
Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Endothelium, Vascular; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxidase | 2007 |
Pressure-related increase of asymmetric dimethylarginine caused by hyperbaric oxygen in the rat brain: a possible neuroprotective mechanism.
Topics: Animals; Arginine; Brain; Hyperbaric Oxygenation; Male; Nitrates; Nitrites; Rats; Rats, Sprague-Dawley | 2007 |
Asymmetric dimethylarginine enhances cardiovascular risk prediction in patients with chronic heart failure.
Topics: Aged; Arginine; Austria; Biomarkers; Disease-Free Survival; Female; Heart Failure; Humans; Male; Natriuretic Peptide, Brain; Peptide Fragments; Prognosis; Prospective Studies; Risk Assessment; Ventricular Dysfunction, Left | 2007 |
Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine predict adverse events in patients undergoing noncardiac surgery.
Topics: Arginine; Biomarkers; Cardiovascular Diseases; Female; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Nitric Oxide Synthase; Perioperative Care; Postoperative Complications; Prospective Studies; Risk Assessment; Surgical Procedures, Operative | 2007 |
Aqueous humor levels of asymmetric dimethylarginine (ADMA) are positively associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis.
Topics: Adult; Aged; Aqueous Humor; Arginine; Biomarkers; Chemokine CCL2; Eye Infections; Humans; Middle Aged; Uveitis | 2008 |
Plasma asymmetric dimethylarginine concentration during the perinatal period.
Topics: Adult; Arginine; Blood Circulation; Endothelium, Vascular; Female; Humans; Infant, Newborn; Nitric Oxide; Nitric Oxide Synthase; Placental Circulation; Postpartum Period; Pregnancy; Pregnancy Trimester, Third | 2007 |
Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2.
Topics: Amidohydrolases; Amlodipine; Angiotensin II; Animals; Arginine; Blood Pressure; Coronary Circulation; Coronary Vessels; Creatine Kinase, MB Form; Enzyme Activation; Enzyme Inhibitors; Fibrosis; Heart Diseases; Imidazoles; Mice; Mice, Transgenic; Myocardium; Nitric Oxide; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peptidyl-Dipeptidase A; Pyridines; Time Factors; Tunica Media; Up-Regulation; Vasodilator Agents | 2007 |
[Effect of asymmetric dimethylarginine on the activation of hepatic stellate cells and its mechanism].
Topics: Actins; Animals; Arginine; Cells, Cultured; Collagen Type I; Dose-Response Relationship, Drug; Gene Expression; Hepatocytes; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta | 2007 |
Asymmetric dimethylarginine is a marker of poor prognosis and coronary calcium in systemic lupus erythematosus.
Topics: Adult; Antibodies, Antinuclear; Arginine; Biomarkers; Calcinosis; Coronary Angiography; Coronary Disease; Ethnicity; Female; Humans; Lipids; Lupus Erythematosus, Systemic; Male; Maryland; Prognosis; Risk Factors | 2007 |
Soluble RAGE in type 2 diabetes: association with oxidative stress.
Topics: Arginine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Dinoprost; Enzyme-Linked Immunosorbent Assay; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Oxidative Stress; Receptor for Advanced Glycation End Products; Receptors, Immunologic | 2007 |
Determination of dimethylarginine dimethylaminohydrolase activity in the kidney.
Topics: Amidohydrolases; Animals; Arginine; Citrulline; Kidney; Male; Rats; Rats, Sprague-Dawley; Urea | 2007 |
Plasma adhesion and inflammation markers: asymmetrical dimethyl-L-arginine and secretory phospholipase A2 concentrations before and after laparoscopic gastric banding in morbidly obese patients.
Topics: Adult; Arginine; C-Reactive Protein; Case-Control Studies; Cell Adhesion Molecules; Cohort Studies; Female; Gastroplasty; Group II Phospholipases A2; Humans; Laparoscopy; Male; Obesity, Morbid; Phospholipases A; Phospholipases A2; Weight Loss | 2007 |
Reduced asymmetric dimethylarginine (ADMA) levels mediate in the protection from metabolic syndrome by smoking.
Topics: Arginine; Female; Humans; Male; Metabolic Syndrome; Middle Aged; Obesity; Smoking | 2008 |
Measurement of arginine derivatives in pediatric patients with chronic kidney disease using high-performance liquid chromatography-tandem mass spectrometry.
Topics: Adolescent; Arginine; Biomarkers; Case-Control Studies; Child; Chromatography, High Pressure Liquid; Female; Humans; Kidney Failure, Chronic; Male; Reproducibility of Results; Sensitivity and Specificity; Siblings; Tandem Mass Spectrometry; Time Factors | 2007 |
Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO.
Topics: Acetylcholine; Amidohydrolases; Animals; Arginine; Dose-Response Relationship, Drug; Endothelium-Dependent Relaxing Factors; Gene Expression Regulation, Enzymologic; Isoenzymes; Kidney Cortex; Liver; Male; Mesenteric Arteries; Nitric Oxide; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Messenger; RNA, Small Interfering; Time Factors; Vasodilation; Vasodilator Agents | 2007 |
Methylated arginines in stable and acute patients with coronary artery disease before and after percutaneous revascularization.
Topics: Angioplasty, Balloon, Coronary; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Coronary Artery Disease; Endothelium; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Myocardial Infarction; Nitric Oxide Synthase; Prospective Studies | 2008 |
Presence of asymmetric dimethylarginine gradients across high-grade lesions in patients with coronary artery disease.
Topics: Aged; Angioplasty, Balloon, Laser-Assisted; Arginine; Atherosclerosis; Biomarkers; Coronary Artery Disease; Coronary Vessels; Endothelium, Vascular; Female; Humans; Male; Middle Aged | 2007 |
Lowering asymmetric dimethylarginine--a new mechanism mediating the renoprotective effects of renin-angiotensin system inhibitors in proteinuric patients?
Topics: Amidohydrolases; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Biomarkers; Hemorheology; Humans; Kidney; Kidney Failure, Chronic; Proteinuria; Rats; Renin-Angiotensin System; Vasodilation | 2007 |
Impaired vascular nitric oxide bioactivity in women with previous gestational diabetes.
Topics: Adult; Arginine; Body Mass Index; Diabetes Mellitus, Type 2; Diabetes, Gestational; Diabetic Angiopathies; Endothelium, Vascular; Female; Humans; Insulin Resistance; Male; Nitric Oxide; Obesity; Pregnancy; Reference Values; Risk Factors; Sex Factors; Vasoconstriction; Vasodilation | 2007 |
Brachial artery flow-mediated dilation and asymmetrical dimethylarginine in the cardiovascular risk in young Finns study.
Topics: Adult; Arginine; Biomarkers; Brachial Artery; Cardiovascular Diseases; Cross-Sectional Studies; Endothelium, Vascular; Female; Finland; Follow-Up Studies; Hemorheology; Humans; Male; Nitric Oxide Synthase Type III; Oxidative Stress; Risk; Sampling Studies; Vasodilation | 2007 |
Changes of asymmetric dimethylarginine, nitric oxide, tetrahydrobiopterin, and oxidative stress in patients with acute myocardial infarction by medical treatments.
Topics: Adult; Aged; Arginine; Biopterins; Case-Control Studies; Drug Therapy; Endothelium, Vascular; Female; Humans; Lipoproteins, LDL; Male; Middle Aged; Myocardial Infarction; Nitric Oxide; Oxidative Stress; Superoxides | 2007 |
Tilarginine in patients with acute myocardial infarction and cardiogenic shock.
Topics: Arginine; Enzyme Inhibitors; Glomerular Filtration Rate; Humans; Myocardial Infarction; Nitric Oxide Synthase; Shock, Cardiogenic; Vasoconstrictor Agents | 2007 |
GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo in
Topics: Amidohydrolases; Animals; Arginine; Catalysis; Diabetes Mellitus, Experimental; Dimethylamines; Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Liver; Male; Molecular Structure; Nitrates; Nitrites; Rats; Rats, Wistar; Reproducibility of Results; S-Nitrosothiols | 2007 |
Relations between markers of renal function, coronary risk factors and the occurrence and severity of coronary artery disease.
Topics: Age Factors; Aged; Arginine; Biomarkers; Cohort Studies; Coronary Artery Disease; Cystatin C; Cystatins; Female; Glomerular Filtration Rate; Homocysteine; Humans; Male; Middle Aged; Renal Insufficiency; Risk Factors | 2008 |
Health-associated reference values for arginine, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) measured with high-performance liquid chromatography.
Topics: Adult; Age Distribution; Aged; Arginine; Chromatography, High Pressure Liquid; Female; Health; Humans; Male; Middle Aged; Reference Values | 2007 |
Asymmetric dimethylarginine is increased in chronic thromboembolic pulmonary hypertension.
Topics: Aged; Arginine; Chronic Disease; Endothelial Cells; Enzyme Inhibitors; Female; Humans; Hypertension, Pulmonary; Kaplan-Meier Estimate; Male; Middle Aged; Nitric Oxide Synthase; Osmolar Concentration; Prognosis; Pulmonary Artery; Severity of Illness Index; Thromboembolism | 2007 |
Unchanged asymmetric dimethylarginine levels in non-diabetic, premenopausal obese women who have common risk factors for cardiovascular disease.
Topics: Adult; Arginine; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Case-Control Studies; Female; Humans; Insulin Resistance; Middle Aged; Obesity; Overweight; Premenopause; Regression Analysis; Risk Factors | 2007 |
Oxidative stress in cardiovascular disease: successful translation from bench to bedside?
Topics: Arginine; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Endothelium, Vascular; Hemorheology; Humans; Nitric Oxide; Oxidative Stress; Reactive Oxygen Species; Risk; Thrombosis; Vasodilation | 2007 |
Role of DDAH-1 in lipid peroxidation product-mediated inhibition of endothelial NO generation.
Topics: Aldehydes; Amidohydrolases; Animals; Antioxidants; Arginine; Calcimycin; Calcium; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Glutathione; Humans; Ionophores; Lipid Peroxidation; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Recombinant Proteins | 2007 |
Reduction of asymmetric dimethylarginine involved in the cardioprotective effect of losartan in spontaneously hypertensive rats.
Topics: Animals; Arginine; Blood Pressure; Hypertension; Losartan; Male; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation | 2007 |
Oxidative stress and asymmetric dimethylarginine is independently associated with carotid intima media thickness in peritoneal dialysis patients.
Topics: Adult; Arginine; Biomarkers; Carotid Artery Diseases; Carotid Artery, Common; Female; Glycation End Products, Advanced; Humans; Kidney Failure, Chronic; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Peritoneal Dialysis; Predictive Value of Tests; Risk Factors; Thiobarbituric Acid Reactive Substances; Tunica Intima; Ultrasonography | 2008 |
Plasma asymmetric dimethylarginine and L-arginine levels in patients with cardiac syndrome X.
Topics: Aged; Arginine; Coronary Angiography; Coronary Circulation; Exercise Test; Female; Humans; Male; Microvascular Angina; Middle Aged; Myocardium; Nitric Oxide; Perfusion; Pericardium | 2007 |
Asymmetric dimethylarginine plasma concentrations and L-arginine/asymmetric dimethylarginine ratio in patients with slow coronary flow.
Topics: Adult; Aged; Arginine; Blood Flow Velocity; Cardiovascular Diseases; Case-Control Studies; Chromatography, High Pressure Liquid; Coronary Angiography; Coronary Circulation; Exercise Test; Female; Humans; Male; Middle Aged; Myocardium; Nitric Oxide; Sensitivity and Specificity; Thrombolytic Therapy | 2007 |
Direct analysis of un-derivatized asymmetric dimethylarginine (ADMA) and L-arginine from plasma using mixed-mode ion-exchange liquid chromatography-tandem mass spectrometry.
Topics: Arginine; Chromatography, Ion Exchange; Humans; Reproducibility of Results; Tandem Mass Spectrometry | 2007 |
Asymmetric dimethylarginine is associated with parameters of glucose metabolism in Caucasian but not in African women from South Africa.
Topics: Adult; Arginine; Black People; Body Mass Index; C-Reactive Protein; Cross-Sectional Studies; Fatty Acids, Nonesterified; Female; Glucose; Glucose Tolerance Test; Humans; Insulin; Obesity; Proinsulin; South Africa; White People | 2007 |
Nebivolol reduces asymmetric dimethylarginine in endothelial cells by increasing dimethylarginine dimethylaminohydrolase 2 (DDAH2) expression and activity.
Topics: Adrenergic beta-Antagonists; Amidohydrolases; Antihypertensive Agents; Arginine; Atenolol; Benzopyrans; Cell Line; Endothelial Cells; Ethanolamines; Female; Humans; Male; Nebivolol; Nitric Oxide Synthase Type III; RNA, Messenger | 2007 |
Association of an endogenous inhibitor of nitric oxide synthase with cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Arginine; Arnold-Chiari Malformation; Citrulline; Enzyme Inhibitors; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Nitric Oxide Synthase; Nitrites; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2007 |
Asymmetrical dimethylarginine, inflammatory and metabolic parameters in women with polycystic ovary syndrome before and after metformin treatment.
Topics: Adult; Androgens; Arginine; Blood Glucose; Body Mass Index; C-Reactive Protein; Cholesterol, LDL; Cross-Sectional Studies; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Polycystic Ovary Syndrome; Statistics, Nonparametric; Triglycerides; Waist-Hip Ratio | 2008 |
Assessment of protein-incorporated arginine methylation in biological specimens by CZE UV-detection.
Topics: Arginine; Blood Proteins; Cells, Cultured; Electrophoresis, Capillary; Endothelium, Vascular; Feasibility Studies; Humans; Methylation; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Proteins; Sensitivity and Specificity; Specimen Handling; Spectrophotometry, Ultraviolet; Umbilical Veins | 2007 |
Reduction of NO- and EDHF-mediated vasodilatation in hypertension: role of asymmetric dimethylarginine.
Topics: Animals; Arginine; Biological Factors; Cell Culture Techniques; Down-Regulation; Epoprostenol; Female; Humans; Hypertension; Male; Mesenteric Arteries; Nitric Oxide; Nitric Oxide Synthase; Potassium Channels, Calcium-Activated; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Small-Conductance Calcium-Activated Potassium Channels; Vasodilation | 2007 |
Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals.
Topics: Animals; Arginine; Blood Pressure; Disease Models, Animal; Diuresis; Enzyme Inhibitors; Hydronephrosis; Hypertension; Indazoles; Kidney; Kidney Cortex; Kidney Tubules, Proximal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Sodium Chloride, Dietary; Ureteral Obstruction | 2008 |
A new selective pre-column ninhydrin-based derivatization for a RP-HPLC determination of plasma asymmetric dimethyl-L-arginine (ADMA) by fluorescence detection.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Chromatography, High Pressure Liquid; Female; Fluorescence; Humans; Male; Middle Aged; Ninhydrin; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Time Factors | 2008 |
Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation.
Topics: Acetylcholine; Amidohydrolases; Animals; Aorta; Arginine; Arterioles; Cardiovascular Diseases; Carotid Arteries; Cerebrovascular Circulation; Endothelium, Vascular; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Vasodilator Agents | 2008 |
Asymmetric dimethylarginine and impaired cardiovascular healing.
Topics: Apoptosis; Arginine; Cardiovascular Diseases; Humans; Kidney Diseases; Myocardial Ischemia; Nitric Oxide; Prognosis; Regeneration; Stem Cells; Treatment Outcome | 2009 |
Simultaneous assessment of endothelial function, nitric oxide synthase activity, nitric oxide-mediated signaling, and oxidative stress in individuals with and without hypercholesterolemia.
Topics: Adolescent; Adult; Aged; Arginine; Cyclic GMP; Dinoprost; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Sex Factors | 2008 |
Methylglyoxal and methylglyoxal-arginine adducts do not directly inhibit endothelial nitric oxide synthase.
Topics: Anthracenes; Arginine; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide Synthase Type III; Propane; Pyruvaldehyde; Umbilical Veins | 2008 |
Effect of angiotensin-converting enzyme inhibitor on serum asymmetric dimethylarginine and coronary circulation in patients with type 2 diabetes mellitus.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Arginine; Coronary Circulation; Diabetes Mellitus, Type 2; Female; Humans; Male; Thiazepines | 2009 |
Urotensin II and cardiomyopathy in end-stage renal disease.
Topics: Adult; Aged; Arginine; Cardiomyopathies; Cardiotonic Agents; Echocardiography; Female; Heart Atria; Humans; Kidney Failure, Chronic; Male; Medical Records; Middle Aged; Multivariate Analysis; Nitric Oxide; Sympathetic Nervous System; Urotensins; Ventricular Function, Left | 2008 |
Contrast-induced nephropathy and mortality: possible crucial role of asymmetric dimethylarginine.
Topics: Acetylcysteine; Angioplasty, Balloon, Coronary; Antioxidants; Arginine; Biomarkers; Contrast Media; Coronary Angiography; Humans; Kidney Diseases; Nitric Oxide | 2007 |
Elevated asymmetric dimethylarginine concentrations precede clinical preeclampsia, but not pregnancies with small-for-gestational-age infants.
Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Female; Humans; Infant, Newborn; Infant, Small for Gestational Age; Pre-Eclampsia; Predictive Value of Tests; Pregnancy; Pregnancy Outcome; Probability; Reference Values; Risk Assessment; Sampling Studies; Sensitivity and Specificity | 2008 |
Dysfunction of endothelial NO system originated from homocysteine-induced aberrant methylation pattern in promoter region of DDAH2 gene.
Topics: Amidohydrolases; Arginine; Cells, Cultured; DNA Methylation; Homocysteine; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Promoter Regions, Genetic | 2007 |
ADMA correlates with portal pressure in patients with compensated cirrhosis by Vizzutti et al. Eur J Clin Invest 2007; 37: 509-15.
Topics: Arginine; Humans; Liver Cirrhosis; Nitric Oxide; Portal Pressure | 2008 |
Elevated asymmetric dimethylarginine (ADMA) and inverse correlation between circulating ADMA and glomerular filtration rate in children with sporadic focal segmental glomerulosclerosis (FSGS).
Topics: Adolescent; Arginine; Child; Child, Preschool; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Humans; Nitric Oxide | 2008 |
Polycystic ovarian syndrome, biomarkers, and metformin: research, risk, and reality.
Topics: Arginine; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Risk Factors | 2008 |
Determination of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, in umbilical blood.
Topics: Adolescent; Adult; Arginine; Child; Child, Preschool; Enzyme Inhibitors; Female; Fetal Blood; Humans; Infant, Newborn; Infant, Premature; Linear Models; Male; Middle Aged; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Pregnancy; Umbilical Veins | 2008 |
ADMA levels correlate with proteinuria, secondary amyloidosis, and endothelial dysfunction.
Topics: Adult; Amyloidosis; Arginine; Chronic Disease; Endothelium; Female; Glomerulonephritis; Humans; Male; Multivariate Analysis; Predictive Value of Tests; Proteinuria; Risk Factors | 2008 |
Human recombinant erythropoietin augments serum asymmetric dimethylarginine concentrations but does not compromise nitric oxide generation in mice.
Topics: Amidohydrolases; Animals; Arginine; Base Sequence; Cells, Cultured; DNA Primers; Endothelial Cells; Epoetin Alfa; Erythropoietin; Humans; Kidney; Kidney Failure, Chronic; Liver; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase Type II; Recombinant Proteins; Up-Regulation; Vascular Diseases | 2008 |
Asymmetric dimethylarginine and lipid peroxidation products in early autosomal dominant polycystic kidney disease.
Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Cross-Sectional Studies; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Humans; Linoleic Acids; Lipid Peroxidation; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Polycystic Kidney, Autosomal Dominant | 2008 |
Response of asymmetric dimethylarginine to hemodialysis-associated hypotension in end-stage renal disease patients.
Topics: Aged; Arginine; Biomarkers; Blood Pressure Determination; Case-Control Studies; Female; Follow-Up Studies; Humans; Hypotension; Kidney Failure, Chronic; Male; Middle Aged; Probability; Reference Values; Renal Dialysis; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Treatment Outcome | 2008 |
Dimethylarginine dimethylaminohydrolase overexpression enhances insulin sensitivity.
Topics: Amidohydrolases; Animals; Arginine; Female; Gene Expression; Glucose Tolerance Test; Glycogen; Humans; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Skeletal; Nitric Oxide; Recombinant Proteins | 2008 |
Effect of telmisartan on nitric oxide--asymmetrical dimethylarginine system: role of angiotensin II type 1 receptor gamma and peroxisome proliferator activated receptor gamma signaling during endothelial aging.
Topics: Acrylates; Amidohydrolases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Anilides; Arginine; Benzimidazoles; Benzoates; Cells, Cultured; Cellular Senescence; Down-Regulation; Endothelium, Vascular; Humans; Imidazoles; Nitric Oxide; Oxidative Stress; PPAR gamma; Receptor, Angiotensin, Type 1; Signal Transduction; Telmisartan; Thiophenes; Up-Regulation | 2008 |
First-trimester uterine artery resistance and maternal serum concentration of asymmetric dimethylarginine.
Topics: Adult; Arginine; Arteries; Blood Pressure; Female; Humans; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, First; Ultrasonography, Doppler; Uterus; Vascular Resistance | 2008 |
Increased plasma asymmetric dimethylarginine (ADMA) levels in retinal venous occlusive disease.
Topics: Aged; Arginine; Case-Control Studies; Cohort Studies; Cysteine; Female; Humans; Male; Middle Aged; Retinal Vein Occlusion; Risk Factors | 2008 |
Impact of asymmetric dimethylarginine on mortality after acute myocardial infarction.
Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Predictive Value of Tests; Prognosis; Prospective Studies; Regression Analysis | 2008 |
Metformin and oral contraceptive treatments reduced circulating asymmetric dimethylarginine (ADMA) levels in patients with polycystic ovary syndrome (PCOS).
Topics: Adult; Androgens; Arginine; Body Mass Index; Case-Control Studies; Contraceptives, Oral; Cyproterone Acetate; Ethinyl Estradiol; Female; Gonadotropins; Humans; Insulin Resistance; Metformin; Polycystic Ovary Syndrome; Time Factors | 2008 |
Involvement of the endothelial DDAH/ADMA pathway in nitroglycerin tolerance: the role of ALDH-2.
Topics: Acetylcysteine; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Amidohydrolases; Arginine; Cell Line; Cyclic GMP; Drug Tolerance; Endothelial Cells; Humans; Lipid Peroxides; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitroglycerin; Oxidative Stress; Reactive Oxygen Species | 2008 |
Asymmetric dimethylarginine independently predicts fatal and nonfatal myocardial infarction and stroke in women: 24-year follow-up of the population study of women in Gothenburg.
Topics: Adult; Arginine; Biomarkers; Cohort Studies; Female; Follow-Up Studies; Homocysteine; Humans; Longitudinal Studies; Middle Aged; Myocardial Infarction; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Factors; Stroke; Sweden | 2008 |
Effects of moderate hyperhomocysteinaemia induced by 4 weeks methionine-enriched diet on metabolite profile and mesenteric artery function in rats.
Topics: Animals; Arginine; Biomarkers; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Diet; Homocysteine; Hyperhomocysteinemia; Male; Mesenteric Arteries; Methionine; Rats; Rats, Wistar; Vasodilation | 2008 |
Endothelin-1 and asymmetric dimethylarginine in children with left-to-right shunt after intracardiac repair.
Topics: Adolescent; Adult; Arginine; Biomarkers; Cardiopulmonary Bypass; Child; Child, Preschool; Endothelin-1; Female; Humans; Hypertension, Pulmonary; Infant; Male; Nitric Oxide Synthase; Pancreatitis-Associated Proteins; Postoperative Complications; Prospective Studies; Statistics, Nonparametric; Time Factors; Treatment Outcome; Young Adult | 2008 |
[Differentiation of 2 endothelial progenitor cells in vitro and inhibitory effect of asymmetric dimethylarginine on its proliferation].
Topics: Arginine; Cell Differentiation; Cell Proliferation; Cells, Cultured; Culture Media; Depression, Chemical; Endothelial Cells; Fetal Blood; Humans; Leukocytes, Mononuclear; Stem Cells | 2008 |
Gene transfer of dimethylarginine dimethylaminohydrolase-2 improves the impairments of DDAH/ADMA/NOS/NO pathway in endothelial cells induced by lysophosphatidylcholine.
Topics: Amidohydrolases; Arginine; Cell Line, Transformed; Cell Survival; Endothelial Cells; Enzyme Inhibitors; Enzyme Repression; Humans; Lysophosphatidylcholines; Nitric Oxide; Nitric Oxide Synthase; Signal Transduction; Transcription, Genetic; Transfection | 2008 |
Anti-hypertensive effects of Rosuvastatin are associated with decreased inflammation and oxidative stress markers in hypertensive rats.
Topics: Animals; Antihypertensive Agents; Arginine; Blood Pressure; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-4; Male; NADPH Oxidases; Oxidative Stress; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Rosuvastatin Calcium; Sulfonamides | 2008 |
Asymmetric dimethylarginine and cardiac allograft vasculopathy progression: modulation by sirolimus.
Topics: Adult; Aged; Arginine; Biomarkers; Heart Transplantation; Humans; Hyperplasia; Immunosuppressive Agents; Longitudinal Studies; Middle Aged; Sirolimus; Transplantation, Homologous; Tunica Intima; Ultrasonography; Vascular Diseases | 2008 |
Asymmetrical dimethylarginine level in atrial fibrillation.
Topics: Acute Disease; Arginine; Atrial Fibrillation; Chromatography, High Pressure Liquid; Chronic Disease; Humans; Middle Aged | 2008 |
Plasma concentrations of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell patients but do not increase further during painful crisis.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Arginine; Child; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Stereoisomerism | 2008 |
Asymmetric dimethylarginine inhibits HSP90 activity in pulmonary arterial endothelial cells: role of mitochondrial dysfunction.
Topics: Adenosine Triphosphate; Animals; Arginine; Cells, Cultured; HSP90 Heat-Shock Proteins; Humans; Ion Channels; Mitochondria; Mitochondrial Proteins; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Protein Binding; Protein Transport; Pulmonary Artery; Recombinant Proteins; Sheep; Signal Transduction; Superoxides; Tyrosine; Uncoupling Protein 2 | 2008 |
Alpha-defensin-like product and asymmetric dimethylarginine increase in mesenteric lymph after hemorrhage in anesthetized rat.
Topics: alpha-Defensins; Anesthesia; Animals; Antimicrobial Cationic Peptides; Arginine; Enzyme-Linked Immunosorbent Assay; Hemorrhage; Inflammation; Intestinal Mucosa; Lymph Nodes; Male; Phospholipases A2; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
[Does tobacco smoke influence the concentration of asymmetric dimethylarginine (ADMA) in healthy males plasma?].
Topics: Adolescent; Adult; Arginine; Cotinine; Humans; Male; Middle Aged; Smoking; Surveys and Questionnaires; Tobacco Smoke Pollution | 2007 |
Role of endogenous nitric oxide synthase inhibitor in gastric mucosal injury.
Topics: Amidohydrolases; Animals; Arginine; Campylobacter jejuni; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Ethanol; Gastric Acid; Gastric Mucosa; Helicobacter pylori; Humans; Indomethacin; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Stomach Diseases; Tumor Necrosis Factor-alpha | 2008 |
Putative role of asymmetric dimethylarginine in microvascular disease of kidney and heart in hypertensive patients.
Topics: Aged; Arginine; Carotid Arteries; Echocardiography; Female; Glomerular Filtration Rate; Heart Diseases; Humans; Hypertension; Male; Middle Aged; Renal Insufficiency | 2008 |
Disturbed angiogenesis in systemic sclerosis: high levels of soluble endoglin.
Topics: Adult; Aged; Antigens, CD; Arginine; Biomarkers; Cross-Sectional Studies; Endoglin; Female; Humans; Male; Middle Aged; Neovascularization, Pathologic; Receptors, Cell Surface; Scleroderma, Systemic; Solubility; Vascular Endothelial Growth Factor A | 2008 |
The homocysteine paradox.
Topics: Animals; Arginine; Cardiovascular Diseases; Cystatin C; Cystatins; Disease Models, Animal; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Diseases; Risk Factors; Vitamin B 12; Vitamin B 6 | 2008 |
Effect of acute variations of insulin and glucose on plasma concentrations of asymmetric dimethylarginine in young people with Type 1 diabetes.
Topics: Adolescent; Arginine; Biomarkers; Blood Glucose; Creatinine; Diabetes Mellitus, Type 1; Drug Administration Schedule; Female; Glucose Clamp Technique; Humans; Insulin; Male; Phenylalanine; Valine; Young Adult | 2008 |
Glomerular filtration and coronary flow: is ADMA the faucet regulating both?
Topics: Arginine; Coronary Circulation; Glomerular Filtration Rate; Humans; Nitric Oxide Synthase | 2008 |
Oxidative stress and asymmetric dimethylarginine are associated with cardiovascular complications in hemodialysis patients: improvements by L-arginine intake.
Topics: Aged; Arginine; Cardiovascular Diseases; Case-Control Studies; Homocysteine; Humans; Kidney Failure, Chronic; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Peroxidase; Renal Dialysis; Risk Factors | 2008 |
Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension.
Topics: AC133 Antigen; Aged; Antigens, CD; Antigens, CD34; Arginine; Cells, Cultured; Cyclic GMP; Down Syndrome; Eisenmenger Complex; Endothelium, Vascular; Exercise; Female; Flow Cytometry; Glycoproteins; Hematopoietic Stem Cells; Humans; Hypertension, Pulmonary; Inflammation Mediators; Male; Middle Aged; Natriuretic Peptide, Brain; Peptides; Piperazines; Pulmonary Artery; Purines; Sildenafil Citrate; Stem Cells; Sulfones; Vascular Endothelial Growth Factor Receptor-2; Vasodilator Agents | 2008 |
Asymmetric dimethylarginine (ADMA) is tightly correlated with growth in juveniles without correlations to obesity related disorders.
Topics: Adolescent; Alkaline Phosphatase; Arginine; Atherosclerosis; Blood Pressure; Body Mass Index; Child; Female; Growth; Humans; Male; Obesity; Reference Values; Regression Analysis; Young Adult | 2008 |
Evaluation of the relationship between flow-mediated vasodilation and some atherogenic risk markers in severe hypercholesterolemia.
Topics: Arginine; Atherosclerosis; Biomarkers; Cholesterol, LDL; Humans; Hypercholesterolemia; Risk Factors; Vasodilation | 2008 |
Asymmetric dimethylarginine (ADMA) has a role in regulating systemic vascular tone in young healthy subjects: the cardiovascular risk in young Finns study.
Topics: Adult; Arginine; Blood Pressure; Cardiovascular Diseases; Female; Finland; Humans; Kidney; Lipids; Male; Nitric Oxide; Risk Factors; Vascular Resistance; Vasoconstriction; Young Adult | 2008 |
Symmetric dimethylarginine is an independent predictor of intradialytic hypotension.
Topics: Aged; Arginine; Biomarkers; Blood Pressure; Female; Humans; Hypotension; Kidney Failure, Chronic; Male; Middle Aged; omega-N-Methylarginine; Predictive Value of Tests; Renal Dialysis | 2008 |
Regulation of eNOS-derived superoxide by endogenous methylarginines.
Topics: Arginine; Biopterins; Electron Spin Resonance Spectroscopy; Heme; Humans; NADP; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Superoxides | 2008 |
Coronary artery calcification, ADMA, and insulin resistance in CKD patients.
Topics: Aged; Arginine; Calcinosis; Case-Control Studies; Chronic Disease; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Insulin Resistance; Kidney Diseases; Male; Middle Aged; Risk Assessment; Severity of Illness Index; Tomography, X-Ray Computed | 2008 |
[Asymmetric dimethil-arginine (ADMA) as a link between insulin resistance and atherosclerosis].
Topics: Adult; Arginine; Atherosclerosis; Cardiovascular Diseases; Carotid Stenosis; Chromatography; Enzyme Inhibitors; Female; Homocysteine; Humans; Insulin Resistance; Linear Models; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Risk Factors; Tunica Intima; Tunica Media; Ultrasonography, Doppler, Color | 2008 |
Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia.
Topics: Amidohydrolases; Animals; Arginine; Carotid Arteries; Cell Line; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; RNA, Messenger; Vasodilation; Vasodilator Agents | 2008 |
The relationship among asymmetric dimethylarginine (ADMA) levels, residual renal function, and left ventricular hypertrophy in continuous ambulatory peritoneal dialysis patients.
Topics: Adult; Analysis of Variance; Arginine; Biomarkers; Case-Control Studies; Creatinine; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Hypertrophy, Left Ventricular; Incidence; Kidney Failure, Chronic; Kidney Function Tests; Male; Middle Aged; Multivariate Analysis; Peritoneal Dialysis, Continuous Ambulatory; Probability; Reference Values; Regression Analysis; Risk Assessment; Severity of Illness Index; Survival Rate; Treatment Outcome; Ultrasonography | 2008 |
Plasma asymmetric dimethylarginine and cardiovascular events in patients with acute decompensated heart failure.
Topics: Aged; Arginine; Austria; Cohort Studies; Female; Heart Failure; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Prospective Studies; Risk Assessment; Ventricular Dysfunction, Left | 2008 |
Differential long-term effects of carvedilol on proinflammatory and antiinflammatory cytokines, asymmetric dimethylarginine, and left ventricular function in patients with heart failure.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Arginine; Carbazoles; Carvedilol; Cytokines; Drug Administration Schedule; Female; Heart Failure; Humans; Interleukin-10; Interleukin-18; Male; Propanolamines; Prospective Studies; Ventricular Function, Left | 2008 |
EPO induces rise in serum ADMA but does not prevent the increase in NO release: the likely involvement of HO-1.
Topics: Animals; Apoptosis; Arginine; Endothelium, Vascular; Epoetin Alfa; Erythropoietin; Heme Oxygenase-1; Humans; Kidney Failure, Chronic; Nitric Oxide; Nitric Oxide Synthase; Recombinant Proteins; Renal Dialysis | 2008 |
Determination of dimethylarginine levels in rats using HILIC-MS/MS: an in vivo microdialysis study.
Topics: Animals; Arginine; Chromatography, Liquid; Enzyme Inhibitors; Microdialysis; Nitric Oxide Synthase; Prefrontal Cortex; Rats; Rats, Wistar; Reference Standards; Tandem Mass Spectrometry | 2008 |
Asymmetrical dimethylarginine is increased in plasma and decreased in cerebrospinal fluid of patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Arginine; Biomarkers; Body Mass Index; Case-Control Studies; Cognition Disorders; Female; Humans; Hypercholesterolemia; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Risk Factors | 2008 |
[The effect of plasma asymmetric dimethylarginine (ADMA) level and L-arginine/ADMA ratio on the development of coronary collaterals].
Topics: Arginine; Chromatography, High Pressure Liquid; Collateral Circulation; Confidence Intervals; Coronary Stenosis; Female; Humans; Logistic Models; Male; Middle Aged; Nitric Oxide Synthase; Odds Ratio; Risk Factors | 2008 |
Association of asymmetric dimethylarginine with sickle cell disease-related pulmonary hypertension.
Topics: Adult; Anemia, Sickle Cell; Arginine; Biomarkers; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged | 2008 |
Evaluation of mobile phase, ion pairing, and temperature influence on an HILIC-MS/MS method for L-arginine and its dimethylated derivatives detection.
Topics: Acrylonitrile; Arginine; Blood Chemical Analysis; Chromatography, Liquid; Indicators and Reagents; Reference Standards; Tandem Mass Spectrometry; Temperature; Trifluoroacetic Acid | 2008 |
Relationship between serum pre-B cell colony-enhancing factor/visfatin and atherosclerotic parameters in chronic hemodialysis patients.
Topics: Aged; Aorta; Arginine; Arteries; Atherosclerosis; B-Lymphocytes; Body Mass Index; C-Reactive Protein; Chronic Disease; Female; Humans; Male; Middle Aged; Nicotinamide Phosphoribosyltransferase; Renal Dialysis | 2009 |
Down-regulation of asymmetric arginine methylation during replicative and H2O2-induced premature senescence in WI-38 human diploid fibroblasts.
Topics: Arginine; Cell Line; Cell Proliferation; Cellular Senescence; Down-Regulation; Fibroblasts; HeLa Cells; Humans; Hydrogen Peroxide; Methylation; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases | 2008 |
Asymmetric dimethylarginine, oxidative stress, and vascular nitric oxide synthase in essential hypertension.
Topics: Adult; Arginine; Blood Pressure; Buttocks; Endothelium-Dependent Relaxing Factors; Female; Humans; Hypertension; Linoleic Acids; Lipid Peroxidation; Male; Microvessels; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Subcutaneous Tissue; Up-Regulation; Vasodilation; Young Adult | 2009 |
Obstructive sleep apnoea syndrome is associated with enhanced sub-clinical inflammation and asymmetric dimethyl-arginine levels in hypertensives.
Topics: Adult; Arginine; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases; Cross-Sectional Studies; Endothelium, Vascular; Female; Humans; Hypertension; Inflammation; Interleukin-18; Interleukin-6; Male; Middle Aged; Risk Factors; Severity of Illness Index; Sleep Apnea, Obstructive; Tumor Necrosis Factor-alpha | 2009 |
Determination of protein-incorporated methylated arginine reference values in healthy subjects whole blood and evaluation of factors affecting protein methylation.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Female; Health; Humans; Male; Methylation; Middle Aged; omega-N-Methylarginine; Proteins; Reference Values; Regression Analysis | 2008 |
Plasma level of asymmetric dimethylarginine (ADMA) as a predictor of carotid intima-media thickness progression: six-year prospective study using carotid ultrasonography.
Topics: Aged; Arginine; Atherosclerosis; Carotid Arteries; Disease Progression; Female; Humans; Linear Models; Male; Middle Aged; Prospective Studies; Tunica Intima; Tunica Media; Ultrasonography | 2008 |
L-Arginine is related to endothelium-dependent vasodilation in resistance and conduit arteries in divergent ways-The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study.
Topics: Aged; Arginine; Arteries; Endothelium; Endothelium-Dependent Relaxing Factors; Female; Humans; Linear Models; Male; Nitric Oxide; Prospective Studies; Vasodilation; Vasodilator Agents | 2009 |
Decrease in the synthesis and release of calcitonin gene-related peptide in dorsal root ganglia of spontaneously hypertensive rat: role of nitric oxide synthase inhibitors.
Topics: Animals; Arginine; Blood Pressure; Calcitonin Gene-Related Peptide; Cells, Cultured; Ganglia, Spinal; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroso Compounds; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Species Specificity | 2008 |
Increased asymmetric dimethylarginine levels in young men with familial Mediterranean fever (FMF): is it early evidence of interaction between inflammation and endothelial dysfunction in FMF?
Topics: Adult; Arginine; C-Reactive Protein; Case-Control Studies; Colchicine; Endothelium, Vascular; Familial Mediterranean Fever; Humans; Inflammation; Lipids; Male; Young Adult | 2008 |
Development and validation of a fast quantitative method for plasma dimethylarginines analysis using liquid chromatography-tandem mass spectrometry.
Topics: Arginine; Calibration; Chromatography, Liquid; Humans; Quality Control; Reproducibility of Results; Tandem Mass Spectrometry | 2008 |
Blood content of asymmetric dimethylarginine: new insights into its dysregulation in renal disease.
Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Erythrocytes; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Peptide Hydrolases; Plasma | 2009 |
Relationship of asymmetric dimethylarginine with flow-mediated dilatation in subjects with newly detected severe hypercholesterolemia.
Topics: Adult; Arginine; Biomarkers; Brachial Artery; Case-Control Studies; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Lipids; Male; Regional Blood Flow; Severity of Illness Index; Ultrasonography; Up-Regulation; Vasodilation | 2008 |
Nitric oxide upregulates dimethylarginine dimethylaminohydrolase-2 via cyclic GMP induction in endothelial cells.
Topics: Amidohydrolases; Animals; Arginine; Carbazoles; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Male; Natriuretic Peptide, C-Type; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitro Compounds; omega-N-Methylarginine; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Up-Regulation | 2008 |
Plasma asymmetric dimethylarginine, L-arginine and left ventricular structure and function in a community-based sample.
Topics: Aged; Arginine; Female; Heart Atria; Heart Ventricles; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Myocardial Contraction; Obesity; Population Surveillance; Risk Assessment; Risk Factors; Ultrasonography; Ventricular Dysfunction, Left | 2009 |
Elevated plasma adiponectin and decreased plasma homocysteine and asymmetric dimethylarginine in children with type 1 diabetes.
Topics: Adiponectin; Adolescent; Arginine; C-Reactive Protein; Case-Control Studies; Child; Child, Preschool; Confidence Intervals; Diabetes Mellitus, Type 1; Female; Homocysteine; Humans; Intercellular Adhesion Molecule-1; Male; Statistics, Nonparametric | 2009 |
ADMA impairs nitric oxide-mediated arteriolar function due to increased superoxide production by angiotensin II-NAD(P)H oxidase pathway.
Topics: Acetophenones; Angiotensin II; Animals; Arginine; Arterioles; Enzyme Inhibitors; Losartan; Male; Muscle, Skeletal; NADPH Oxidases; Nitric Oxide; Oxidative Stress; Quinapril; Rats; Rats, Wistar; Signal Transduction; Superoxides; Tetrahydroisoquinolines; Vasoconstriction; Vasodilation | 2008 |
Endogenous nitric oxide synthase inhibitors, arterial hemodynamics, and subclinical vascular disease: the PREVENCION Study.
Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Blood Flow Velocity; Blood Pressure; Carotid Artery Diseases; Female; Humans; Hypertension; Male; Middle Aged; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Predictive Value of Tests; Prognosis; Pulsatile Flow; Regression Analysis; Risk Factors | 2008 |
Modulation of Rac1 activity by ADMA/DDAH regulates pulmonary endothelial barrier function.
Topics: Adherens Junctions; Amidohydrolases; Animals; Antigens, CD; Arginine; Cadherins; cdc42 GTP-Binding Protein; Cell Adhesion Molecules; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases; Cytoskeleton; Endothelium; Enzyme Activation; Enzyme Inhibitors; Isoenzymes; Lung; Mice; Mice, Knockout; Microfilament Proteins; Nitric Oxide; Nitric Oxide Synthase; Permeability; Phosphoproteins; rac1 GTP-Binding Protein; Reactive Oxygen Species; rhoA GTP-Binding Protein; Swine | 2009 |
Asymmetric dimethylarginine and coronary collateral vessel development.
Topics: Adult; Aged; Arginine; Biomarkers; Collateral Circulation; Coronary Angiography; Coronary Circulation; Coronary Stenosis; Female; Humans; Male; Middle Aged; Odds Ratio | 2008 |
Relation between asymmetric dimethylarginine (ADMA) and hearing loss in patients with renal impairment.
Topics: Adult; Arginine; C-Reactive Protein; Case-Control Studies; Creatinine; Female; Hearing Loss, Sensorineural; Humans; Lipids; Male; Middle Aged; Renal Insufficiency, Chronic; Risk Factors | 2008 |
Asymmetric dimethylarginine levels decrease because of insulin infusion: is it an unexpected finding?
Topics: Arginine; Humans; Insulin; Insulin Resistance | 2008 |
Increased plasma levels of asymmetric dimethylarginine and soluble CD40 ligand in patients with sleep apnea.
Topics: Adult; Arginine; Atherosclerosis; Cardiovascular Diseases; Case-Control Studies; CD40 Ligand; Endothelin-1; Humans; Male; Middle Aged; Risk Factors; Sleep Apnea, Obstructive | 2009 |
Unchanged plasma levels of dimethylarginines and nitric oxide in chronic hepatitis C.
Topics: Adult; Antiviral Agents; Arginine; Case-Control Studies; Female; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Nitric Oxide; Polyethylene Glycols; Recombinant Proteins; Ribavirin | 2009 |
Smoker's paradox in heart failure: might asymmetric dimethylarginine be the possible explanation?
Topics: Arginine; Cardiovascular Diseases; Heart Failure; Hospital Mortality; Humans; Smoking | 2008 |
Plasma levels of asymmetric dimethylarginine in cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy.
Topics: Adult; Antihypertensive Agents; Arginine; Biomarkers; Brain; CADASIL; Chromatography, High Pressure Liquid; Endothelium, Vascular; Female; Humans; Hypertension; Lipids; Magnetic Resonance Imaging; Male; Middle Aged; Receptor, Notch3; Receptors, Notch; Risk Factors | 2008 |
Plasma ADMA concentrations at birth and mechanical ventilation in preterm infants: a prospective pilot study.
Topics: Arginine; Female; Gestational Age; Humans; Infant, Newborn; Male; Nitric Oxide Synthase; Pilot Projects; Premature Birth; Prospective Studies; Respiration, Artificial; Respiratory Distress Syndrome, Newborn; Time Factors | 2008 |
Plasma levels of asymmetric dimethylarginine in premature neonates: its possible involvement in developmental programming of chronic diseases.
Topics: Arginine; Cardiovascular Diseases; Chronic Disease; Diabetes Mellitus, Type 2; Female; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Male; Metabolic Syndrome | 2009 |
Carotid intima-media thickness in patients with cardiac syndrome X and its association with high circulating levels of asymmetric dimethylarginine.
Topics: Adult; Arginine; Carotid Artery Diseases; Carotid Artery, Common; Case-Control Studies; Female; Humans; Male; Microvascular Angina; Middle Aged; Nitrates; Nitrites; Tunica Intima; Tunica Media; Ultrasonography; Up-Regulation | 2009 |
Involvement of asymmetric dimethylarginine (ADMA) in tubulointerstitial ischaemia in the early phase of diabetic nephropathy.
Topics: Adenoviridae; Amidohydrolases; Animals; Arginine; Diabetic Nephropathies; Disease Models, Animal; Genetic Vectors; Ischemia; Kidney; Male; Nephritis, Interstitial; Nitric Oxide; Rats; Rats, Sprague-Dawley | 2009 |
HPLC analysis of asymmetric dimethylarginine (ADMA) and related arginine metabolites in human plasma using a novel non-endogenous internal standard.
Topics: Arginine; Chromatography, High Pressure Liquid; Humans; Reference Standards; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction | 2009 |
Asymmetric dimethylarginine predicts outcome and time of stay in hospital in patients attending an internal medicine emergency room.
Topics: Adult; Aged; Arginine; Emergency Service, Hospital; Female; Humans; Length of Stay; Logistic Models; Male; Middle Aged; Prognosis; Proportional Hazards Models; Risk Assessment | 2009 |
Asymmetric dimethylarginine in hematological malignancies: a preliminary study.
Topics: Adult; Aged; Arginine; Biomarkers, Tumor; Case-Control Studies; Female; Hematologic Neoplasms; Humans; Male; Middle Aged; Prognosis; Risk Factors | 2008 |
Evaluation of asymmetric dimethylarginine and homocysteine in microangiopathy-related cerebral damage.
Topics: Arginine; Arteriosclerosis; Biomarkers; Blood Pressure; Brain Damage, Chronic; Cerebral Infarction; Cerebrovascular Disorders; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Homocysteine; Humans; Hypertension; Japan; Magnetic Resonance Imaging; Male; Middle Aged; Nitric Oxide Synthase; Odds Ratio; Regression Analysis; Risk Assessment | 2009 |
Role of symmetric dimethylarginine in vascular damage by increasing ROS via store-operated calcium influx in monocytes.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Arginine; Calcium; Calcium Channel Blockers; Calcium Channels; Captopril; Edetic Acid; Enzyme Inhibitors; Humans; Imidazoles; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Reactive Oxygen Species; Respiratory Burst; Thapsigargin; Vascular Diseases | 2009 |
Advanced oxidative protein products are independently associated with endothelial function in peritoneal dialysis patients.
Topics: Adult; Arginine; Cross-Sectional Studies; Endothelium, Vascular; Female; Glycation End Products, Advanced; Humans; Kidney Failure, Chronic; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress; Peritoneal Dialysis; Regression Analysis | 2009 |
Transjugular intrahepatic portosystemic shunt-placement increases arginine/asymmetric dimethylarginine ratio in cirrhotic patients.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Female; Follow-Up Studies; Humans; Hypertension, Portal; Liver; Liver Cirrhosis; Male; Middle Aged; Nitric Oxide; Portasystemic Shunt, Transjugular Intrahepatic | 2008 |
The beneficial effects of angiotensin-converting enzyme inhibitors on serum asymmetric dimethylarginine levels in the patients with cardiovascular disease.
Topics: Angiotensin-Converting Enzyme Inhibitors; Arginine; Biomarkers; Cardiovascular Diseases; Humans | 2010 |
Asymmetric and symmetric dimethylarginines are of similar predictive value for cardiovascular risk in the general population.
Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Cohort Studies; Female; Humans; Male; Mass Spectrometry; Middle Aged; Nitric Oxide; Proportional Hazards Models; Prospective Studies; Risk | 2009 |
Asymmetric dimethylarginine levels and carotid intima-media thickness in obese patients with polycystic ovary syndrome and their relationship to metabolic parameters.
Topics: Adolescent; Adult; Arginine; Energy Metabolism; Female; Humans; Obesity; Polycystic Ovary Syndrome; Prospective Studies; Tunica Intima; Tunica Media; Ultrasonography; Young Adult | 2010 |
Plasma ADMA predicts restenosis of arteriovenous fistula.
Topics: Adult; Aged; Angioplasty, Balloon; Arginine; Arteriovenous Shunt, Surgical; C-Reactive Protein; Constriction, Pathologic; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multivariate Analysis; Renal Dialysis; Risk Factors | 2009 |
Clinical implications of elevated asymmetric dimethylarginine in chronic kidney disease and end-stage renal disease.
Topics: Arginine; Cardiovascular Diseases; Carotid Arteries; Humans; Kidney Diseases; Kidney Failure, Chronic; Risk Factors; Uremia | 2009 |
Asymmetric dimethylarginine is closely associated with the development and progression of nephropathy in patients with type 2 diabetes.
Topics: Adult; Aged; Albuminuria; Arginine; Biomarkers; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Humans; Japan; Male; Middle Aged; Nitric Oxide Synthase; Prognosis; Proportional Hazards Models; Prospective Studies | 2009 |
Acute effects of Helicobacter pylori extracts on gastric mucosal blood flow in the mouse.
Topics: Animals; Arginine; Blood Flow Velocity; Gastric Mucosa; Helicobacter pylori; Lidocaine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type II; Signal Transduction; Water | 2009 |
Circulating asymmetric dimethylarginine, endothelin-1 and cell adhesion molecules in women with gestational diabetes.
Topics: Adult; Arginine; Blood Glucose; Case-Control Studies; Diabetes, Gestational; Endothelin-1; Female; Humans; Pregnancy; Vascular Cell Adhesion Molecule-1 | 2009 |
Endothelial and red blood cell turnover rate--factors possibly affecting circulating ADMA levels?
Topics: Amidohydrolases; Arginine; Endothelial Cells; Erythrocytes; Erythropoietin; Humans | 2009 |
[The effect of plasma asymmetric dimethylarginine (ADMA) level and L-arginine/ADMA ratio on the development of coronary collaterals].
Topics: Arginine; Collateral Circulation; Coronary Stenosis; Humans; Nitric Oxide Synthase | 2008 |
Losartan inhibits monocytic adhesion induced by ADMA via downregulation of chemokine receptors in monocytes.
Topics: Arginine; Cell Adhesion; Cells, Cultured; Chemokine CCL2; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Humans; Interleukin-8; Losartan; Monocytes; NF-kappa B; Receptors, Chemokine; RNA, Messenger; Time Factors | 2009 |
Asymmetric dimethylarginine induces tissue factor expression in monocytes via NF-kappaB-dependent pathway: Role in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Angina Pectoris; Arginine; Blood Coagulation; Case-Control Studies; Coagulants; Female; Humans; Male; Middle Aged; Monocytes; NF-kappa B; Nitric Oxide Synthase; Thromboplastin | 2009 |
De novo synthesis of trideuteromethyl esters of amino acids for use in GC-MS and GC-tandem MS exemplified for ADMA in human plasma and urine: standardization, validation, comparison and proof of evidence for their aptitude as internal standards.
Topics: Arginine; Gas Chromatography-Mass Spectrometry; Humans; Reference Standards; Tandem Mass Spectrometry | 2009 |
ADMA and SDMA levels in healthy men exposed to tobacco smoke.
Topics: Adolescent; Adult; Arginine; Cerebrovascular Disorders; Coronary Vessels; Humans; Male; Middle Aged; Nitric Oxide Synthase; Regression Analysis; Risk Factors; Smoking; Tobacco Smoke Pollution | 2009 |
Asymmetrical dimethylarginine triggers lipolysis and inflammatory response via induction of endoplasmic reticulum stress in cultured adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Arginine; Carrier Proteins; Cells, Cultured; Endoplasmic Reticulum; Inflammation; Lipolysis; Mice; Muscle Fibers, Skeletal; NF-kappa B; Perilipin-1; Phosphoproteins; Protein Processing, Post-Translational; Stress, Physiological; Up-Regulation | 2009 |
ADMA and the brain: an unfolding story.
Topics: Animals; Arginine; Brain Chemistry; Cattle; Cerebrovascular Circulation; Cerebrovascular Disorders; Cross-Sectional Studies; Glomerular Filtration Rate; Homocysteine; Magnetic Resonance Imaging; Nitric Oxide Synthase | 2009 |
Relationship of baseline plasma ADMA levels to cardiovascular outcomes at 2 years in men with acute coronary syndrome referred for coronary angiography.
Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Arginine; Biomarkers; Coronary Angiography; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Time Factors; Up-Regulation | 2009 |
Telmisartan decreases plasma levels of asymmetrical dimethyl-L-arginine and improves lipid and glucose metabolism and vascular function.
Topics: Administration, Oral; Aged; Angiotensin II Type 1 Receptor Blockers; Arginine; Benzimidazoles; Benzoates; Blood Glucose; Blood Pressure; Cholesterol, LDL; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Humans; Hypertension; Male; Nitric Oxide Synthase Type III; PPAR gamma; Telmisartan; Treatment Outcome | 2009 |
Maternal serum ADMA is not associated with proinflammatory cytokines or C-reactive protein during normal pregnancy.
Topics: Adult; Arginine; Biomarkers; C-Reactive Protein; Creatinine; Cytokines; Enzyme Inhibitors; Female; Gestational Age; Humans; Interleukin-6; Lipids; Pregnancy; Tumor Necrosis Factor-alpha | 2009 |
Determinants of platelet activation in hypertensives with microalbuminuria.
Topics: Aged; Albuminuria; Arginine; Biomarkers; Disease Progression; Endothelium; Female; Humans; Hypertension; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Male; Middle Aged; Nitric Oxide; Oxidative Stress; P-Selectin; Platelet Activation; Prostaglandins A; Thromboxane B2; Vitamin E | 2009 |
Asymmetric dimethylarginine and nitric oxide levels in migraine during the interictal period.
Topics: Adult; Arginine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Migraine Disorders; Nitrates; Nitric Oxide; Nitrites; Statistics, Nonparametric | 2009 |
Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community.
Topics: Aged; Arginine; Cardiovascular Diseases; Cause of Death; Diabetes Mellitus; Follow-Up Studies; Humans; Incidence; Middle Aged; Mortality; Predictive Value of Tests; Prognosis; Proportional Hazards Models | 2009 |
Dimethylarginine levels in cerebrospinal fluid of hyperacute ischemic stroke patients are associated with stroke severity.
Topics: Aged; Arginine; Brain Ischemia; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Stroke | 2009 |
Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis.
Topics: Aged; Arginine; Atherosclerosis; Coronary Artery Bypass; Coronary Artery Disease; Endothelium, Vascular; Female; Humans; Male; Nitric Oxide Synthase Type III; Oxidative Stress; Saphenous Vein; Superoxides; Vasodilation | 2009 |
ADMA injures the glomerular filtration barrier: role of nitric oxide and superoxide.
Topics: Albumins; Animals; Anthracenes; Arginine; Free Radical Scavengers; Glomerular Basement Membrane; Guanylate Cyclase; Male; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidation-Reduction; Permeability; Propane; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Superoxides | 2009 |
Differential effects of cross-sex hormonal treatment on plasma asymmetric dimethylarginine (ADMA) in healthy male-to-female and female-to-male transsexuals.
Topics: Adult; Amino Acids; Androgen Antagonists; Arginine; Cyproterone Acetate; Estradiol; Estrogens; Ethinyl Estradiol; Female; Gonadal Steroid Hormones; Humans; Male; Testosterone; Transsexualism | 2009 |
Correlation of biomarkers of endothelium dysfunction and matrix remodeling in patients with systemic sclerosis.
Topics: Arginine; Biomarkers; Endothelium, Vascular; Enzyme Inhibitors; Extracellular Matrix; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Raynaud Disease; Regional Blood Flow; Scleroderma, Systemic; Skin; Tissue Inhibitor of Metalloproteinase-1 | 2009 |
Relationship between cerebral arterial pulsatility and carotid intima media thickness in diabetic and non-diabetic patients with non-alcoholic fatty liver disease.
Topics: Aged; Arginine; Basilar Artery; Carotid Arteries; Diabetes Mellitus, Type 2; Fatty Liver; Female; Humans; Male; Middle Aged; Pulsatile Flow; Tunica Intima; Tunica Media; Ultrasonography | 2009 |
Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death.
Topics: Anemia, Sickle Cell; Arginine; Case-Control Studies; Citrulline; Follow-Up Studies; Hemolysis; Humans; Hypertension, Pulmonary; Kidney Diseases; Linear Models; Nitric Oxide Synthase; omega-N-Methylarginine; Oxygen; Proportional Hazards Models; Risk; Survival Rate | 2009 |
Involvement of asymmetric dimethylarginine (ADMA) in glomerular capillary loss and sclerosis in a rat model of chronic kidney disease (CKD).
Topics: Amidohydrolases; Animals; Arginine; Capillaries; Disease Models, Animal; Glomerulosclerosis, Focal Segmental; Humans; Kidney Failure, Chronic; Kidney Glomerulus; Rats | 2009 |
Elevation of serum apelin-13 is positively correlated with ADMA in patients on maintenance hemodialysis.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Female; Humans; Intercellular Signaling Peptides and Proteins; Kidney Failure, Chronic; Male; Middle Aged; Nitrates; Nitrites; Renal Dialysis; Time Factors | 2009 |
HDL-cholesterol, blood pressure, and asymmetric dimethylarginine are significantly associated with arterial wall thickness in children.
Topics: Arginine; Biomarkers; Blood Pressure; Cardiovascular Diseases; Carotid Arteries; Carotid Artery Diseases; Child; Cholesterol, HDL; Cross-Sectional Studies; Disease Progression; Female; Humans; Male; New South Wales; Risk Factors; Tunica Intima; Tunica Media; Ultrasonography | 2009 |
Stent placement in patients with coronary heart disease decreases plasma levels of the endogenous nitric oxide synthase inhibitor ADMA.
Topics: Aged; Arginine; Cardiovascular Surgical Procedures; Case-Control Studies; Coronary Disease; Down-Regulation; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitric Oxide Synthase; Stents; Time Factors | 2009 |
Vascular biomarkers in the metabolic syndrome.
Topics: Arginine; Biomarkers; Blood Vessels; Endothelium, Vascular; Enzyme Inhibitors; Glycation End Products, Advanced; Humans; Insulin Resistance; Metabolic Syndrome; Signal Transduction; Stem Cells | 2009 |
Low arginine/asymmetric dimethylarginine ratio deteriorates systemic hemodynamics and organ blood flow in a rat model.
Topics: Animals; Arginine; Hemodynamics; Male; Rats; Rats, Wistar; Regional Blood Flow | 2009 |
Asymmetric dimethylarginine and mortality in stages 3 to 4 chronic kidney disease.
Topics: Adult; Arginine; Cohort Studies; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multivariate Analysis; Nitric Oxide; Prevalence; Proportional Hazards Models; Randomized Controlled Trials as Topic; Renal Insufficiency, Chronic; Risk Factors; Severity of Illness Index | 2009 |
Ezetimibe decreases serum levels of asymmetric dimethylarginine (ADMA) and ameliorates renal injury in non-diabetic chronic kidney disease patients in a cholesterol-independent manner.
Topics: Adult; Arginine; Azetidines; Cholesterol; Dyslipidemias; Ezetimibe; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged | 2009 |
Serum asymmetric dimethylarginine and endothelial function after renal transplantation.
Topics: Adult; Arginine; Case-Control Studies; Endothelium, Vascular; Female; Humans; Kidney Transplantation; Male; Middle Aged; Postoperative Period; Uremia | 2009 |
Circulating levels of advanced glycation end products (AGE) and interleukin-6 (IL-6) are independent determinants of serum asymmetric dimethylarginine (ADMA) levels in patients with septic shock.
Topics: Aged; Arginine; Biomarkers; Female; Glycation End Products, Advanced; Humans; Interleukin-6; Male; Middle Aged; Shock, Septic | 2009 |
Role of anandamide transporter in regulating calcitonin gene-related peptide production and blood pressure in hypertension.
Topics: Animals; Arachidonic Acids; Arginine; Base Sequence; Blood Pressure; Calcitonin Gene-Related Peptide; Carrier Proteins; Case-Control Studies; DNA Primers; Endocannabinoids; Ganglia, Spinal; Humans; Hypertension; Hypertension, Renovascular; In Vitro Techniques; Lymphocytes; Male; Polyunsaturated Alkamides; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; RNA, Messenger | 2009 |
Non-invasive assessment of coronary flow reserve and ADMA levels: a case-control study of early rheumatoid arthritis patients.
Topics: Adult; Aged; Arginine; Arthritis, Rheumatoid; Biomarkers; Carotid Artery, Common; Case-Control Studies; Coronary Circulation; Dipyridamole; Echocardiography, Stress; Female; Humans; Linear Models; Male; Microcirculation; Middle Aged; Nitric Oxide Synthase; Regional Blood Flow; Tunica Media; Vasodilator Agents | 2009 |
Inhibition of natriuretic factors increases blood pressure in rats.
Topics: Amidohydrolases; Animals; Antioxidants; Arginine; Blood Pressure; Buthionine Sulfoximine; Cyclic N-Oxides; Disease Models, Animal; Dopamine; Hypertension; Kidney Tubules, Proximal; Male; Natriuresis; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidants; Oxidative Stress; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Serine; Signal Transduction; Sodium Chloride, Dietary; Sodium-Potassium-Exchanging ATPase; Spin Labels | 2009 |
A study of endothelial function and circulating asymmetric dimethylarginine levels in people with Type 1 diabetes without macrovascular disease or microalbuminuria.
Topics: Adolescent; Adult; Albuminuria; Arginine; Biomarkers; Brachial Artery; Case-Control Studies; Cell Adhesion Molecules; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Endothelium, Vascular; Female; Humans; Male; Nitric Oxide Synthase Type III; Risk Factors; Ultrasonography; Vasodilation; Young Adult | 2009 |
Methylarginines and mortality in patients with end stage renal disease: a prospective cohort study.
Topics: Adult; Aged; Arginine; Biomarkers; Female; Hemoglobins; Humans; Kaplan-Meier Estimate; Kidney Failure, Chronic; Male; Methylation; Middle Aged; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Renal Dialysis; Risk Assessment; Risk Factors | 2009 |
Postmenopausal women with osteoporosis may be associated with high endothelin-1.
Topics: Arginine; Bone Density; Chi-Square Distribution; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Female; Humans; Middle Aged; Osteoporosis, Postmenopausal; Regression Analysis | 2009 |
Asymmetric dimethylarginine reference intervals determined with liquid chromatography-tandem mass spectrometry: results from the Framingham offspring cohort.
Topics: Age Factors; Aged; Arginine; Cardiovascular Diseases; Chromatography, Liquid; Cohort Studies; Female; Homocysteine; Humans; Male; Middle Aged; Multivariate Analysis; Reference Standards; Sensitivity and Specificity; Sex Factors; Tandem Mass Spectrometry | 2009 |
Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: potential mechanisms beyond nitric oxide synthase inhibition.
Topics: Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Citrulline; Coronary Artery Disease; Creatinine; Female; Humans; Lysine; Male; Metabolomics; Methylation; Middle Aged; Nitric Oxide Synthase; Odds Ratio; omega-N-Methylarginine; Ornithine; Prognosis; Prospective Studies; Protein Processing, Post-Translational; Risk Assessment; Risk Factors; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Time Factors | 2009 |
Paradoxical effect of L-arginine: acceleration of endothelial cell senescence.
Topics: Arginase; Arginine; Cationic Amino Acid Transporter 1; Cationic Amino Acid Transporter 2; Cells, Cultured; Cellular Senescence; Endothelial Cells; Endothelium, Vascular; Humans; Nitric Oxide; Oxidative Stress | 2009 |
Correlates of arterial stiffness in an ageing population: role of asymmetric dimethylarginine.
Topics: Aged; Aging; Arginine; Endothelium, Vascular; Female; Humans; Hypertension; Male; Middle Aged; Risk Factors; Vascular Resistance | 2009 |
Renal resistance index in renal allograft recipients: a role for ADMA.
Topics: Adult; Aged; Arginine; Female; Humans; Kidney Transplantation; Male; Middle Aged; Renal Artery; Vascular Resistance; Young Adult | 2009 |
[Relationship between changes of endogenous nitric oxide synthase inhibitor and hydrolase and initiation of pre-eclampsia].
Topics: Adult; Amidohydrolases; Arginine; Chromatography, High Pressure Liquid; Female; Humans; Nitric Oxide; Nitric Oxide Synthase; Placenta; Polymerase Chain Reaction; Pre-Eclampsia; Pregnancy; RNA, Messenger | 2009 |
Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), arginine, and 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha) level in patients with inflammatory bowel diseases.
Topics: Adolescent; Adult; Aged; Arginine; Biomarkers; Case-Control Studies; Colitis, Ulcerative; Crohn Disease; Dinoprost; Female; Humans; Male; Middle Aged; Oxidative Stress; Young Adult | 2010 |
Asymmetric dimethylarginine in the maternal and fetal circulation in preeclampsia.
Topics: Adult; Arginine; Female; Fetus; Humans; Infant, Newborn; Maternal-Fetal Exchange; Nitric Oxide; Pre-Eclampsia; Pregnancy; Young Adult | 2009 |
Asymmetric dimethylarginine impairs glucose utilization via ROS/TLR4 pathway in adipocytes: an effect prevented by vitamin E.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Arginine; Cell Line; Enzyme Inhibitors; Glucose; Glucose Transporter Type 4; Insulin Receptor Substrate Proteins; Mice; Nitric Oxide; Nitric Oxide Synthase; Reactive Oxygen Species; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Vitamin E | 2009 |
Positive association of serum levels of advanced glycation end products and high mobility group box-1 with asymmetric dimethylarginine in nondiabetic chronic kidney disease patients.
Topics: Adult; Arginine; Cross-Sectional Studies; Dyslipidemias; Female; Glycation End Products, Advanced; Hemodynamics; HMGB1 Protein; Humans; Kidney Failure, Chronic; Male; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Regression Analysis | 2009 |
Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginine.
Topics: Amidohydrolases; Animals; Arginine; Cationic Amino Acid Transporter 1; Cell Line; Cells, Cultured; Haplorhini; Humans; Isoxazoles; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase; Receptors, Cytoplasmic and Nuclear | 2009 |
Proteomic identification of cytosolic proteins that undergo arginine methylation during rat liver regeneration.
Topics: Amino Acid Sequence; Animals; Arginine; Cytosol; Electrophoresis, Gel, Two-Dimensional; Liver Regeneration; Mass Spectrometry; Methylation; Molecular Sequence Data; Protein-Arginine N-Methyltransferases; Proteins; Proteomics; Rats; Rats, Sprague-Dawley | 2009 |
Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study.
Topics: Adult; Aged; Arginine; Atherosclerosis; Biomarkers; Brain; Brain Infarction; Cohort Studies; Endothelium, Vascular; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nitric Oxide Synthase Type III; Radiography; Risk Factors | 2009 |
The conjoint detrimental effect of chronic periodontal disease and systemic inflammation on asymmetric dimethyl-arginine in untreated hypertensive subjects.
Topics: Arginine; Chronic Disease; Cross-Sectional Studies; Female; Humans; Hypertension; Inflammation; Male; Middle Aged; Periodontal Diseases | 2010 |
Altered asymmetric dimethyl arginine metabolism in allergically inflamed mouse lungs.
Topics: Amidohydrolases; Animals; Arginine; Asthma; Collagen; Cytosol; Inflammation; Lung; Male; Mice; Mice, Inbred BALB C; Mitochondria; Nitric Oxide Synthase; Peroxynitrous Acid; Protein-Arginine N-Methyltransferases | 2010 |
Plasma concentrations of the cardiovascular risk factor asymmetric dimethylarginine (ADMA) are increased in patients with HIV-1 infection and correlate with immune activation markers.
Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Cohort Studies; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Risk Factors; Th1 Cells; Young Adult | 2009 |
Quantification of arginine and its mono- and dimethylated analogs NMMA, ADMA and SDMA in biological fluids by LC-MS/MS: Is LC superfluous?
Topics: Arginine; Chromatography, Liquid; Humans; Reproducibility of Results; Tandem Mass Spectrometry | 2009 |
Nested case-control study of one-carbon metabolites in mid-pregnancy and risks of cleft lip with and without cleft palate.
Topics: Adult; Arginine; Carbon; Case-Control Studies; Cleft Lip; Cleft Palate; Dietary Supplements; Female; Folic Acid; Humans; Maternal Age; Nutritional Sciences; Odds Ratio; Pregnancy; Vitamins | 2009 |
Increased nitric oxide stress is associated with migraine.
Topics: Adult; Aged; Amidohydrolases; Arginine; Female; Humans; Male; Migraine with Aura; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Polymorphism, Genetic; Risk Factors; Stress, Physiological | 2010 |
Determinants of occurrence of aortic sclerosis in an aging population.
Topics: Age Factors; Aged; Aorta; Aortic Valve; Aortic Valve Stenosis; Arginine; Biomarkers; Blood Platelets; Body Mass Index; Calcinosis; Cardiovascular Diseases; Cross-Sectional Studies; Disease Progression; Echocardiography, Doppler; Elasticity; Endothelium, Vascular; Female; Heart Valve Diseases; Humans; Linear Models; Male; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Platelet Aggregation; Prospective Studies; Pulsatile Flow; Risk Assessment; Risk Factors; Sclerosis | 2009 |
Collagen synthesis, nitric oxide and asymmetric dimethylarginine in diabetic subjects undergoing hyperbaric oxygen therapy.
Topics: Aged; Arginine; Biomarkers; Collagen; Diabetic Foot; Female; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Nitric Oxide; Peptide Fragments; Procollagen; Time Factors; Treatment Outcome; Wound Healing | 2010 |
Increased levels of asymmetric dimethylarginine (ADMA) in patients with ankylosing spondylitis.
Topics: Adult; Arginine; Biomarkers; Endothelin-1; Female; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Risk Factors; Spondylitis, Ankylosing; Up-Regulation | 2009 |
Effect of keto acids on asymmetric dimethylarginine, muscle, and fat tissue in chronic kidney disease and after kidney transplantation.
Topics: Adipose Tissue; Adult; Aged; Amino Acids; Arginine; Body Mass Index; Diet, Protein-Restricted; Humans; Keto Acids; Kidney Failure, Chronic; Kidney Transplantation; Middle Aged; Muscles; Obesity; Randomized Controlled Trials as Topic; Serum Albumin | 2009 |
Is asymmetric dimethylarginine responsible for the vascular events in patients under antiepileptic drug treatment?
Topics: Adult; Anticonvulsants; Arginine; Arterial Occlusive Diseases; Carbamazepine; Drug Monitoring; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Statistics, Nonparametric; Valproic Acid; Vitamin B 12 | 2009 |
Asymmetric dimethylarginine endogenous inhibition of nitric oxide synthase causes differential vasculature effects.
Topics: Animals; Arginine; Arteries; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Humans; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Tissue Culture Techniques | 2009 |
Synergistic effects of asymmetrical dimethyl-L-arginine accumulation and endothelial progenitor cell deficiency on renal function decline during a 2-year follow-up in stable angina.
Topics: Adult; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antigens, CD34; Arginine; Biomarkers; Cell Count; Endothelial Cells; Follow-Up Studies; Glomerular Filtration Rate; Humans; Kidney; Leukocytes; Male; Middle Aged; Multivariate Analysis; Stem Cells | 2010 |
PRMT-1 and DDAHs-induced ADMA upregulation is involved in ROS- and RAS-mediated diabetic retinopathy.
Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Cells, Cultured; Cyclic GMP; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelial Cells; Male; Protein-Arginine N-Methyltransferases; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Renin-Angiotensin System; Up-Regulation | 2009 |
Role of neutrophils in arginine-asymmetric dimethylarginine pathway subsequent to endotoxemia.
Topics: Animals; Arginine; Disease Models, Animal; Endotoxemia; Guinea Pigs; Lipopolysaccharides; Liver; Male; Neutrophils; Peroxidase; Tyrosine | 2009 |
Altered metabolisms of mediators controlling vascular function and enhanced oxidative stress in asymptomatic children with congenital portosystemic venous shunt.
Topics: Amino Acids; Ammonia; Arginine; Blood Vessels; Child, Preschool; Endothelin-1; Female; Humans; Infant; Male; Nitric Oxide; Oxidative Stress; Portal System | 2010 |
Ex vivo gene transferring of human dimethylarginine dimethylaminohydrolase-2 improved endothelial dysfunction in diabetic rat aortas and high glucose-treated endothelial cells.
Topics: Amidohydrolases; Animals; Aorta; Arginine; Diabetes Mellitus; Diabetes Mellitus, Experimental; Endothelium, Vascular; Gene Transfer Techniques; Glucose; Humans; Hyperglycemia; Male; Rats; Rats, Sprague-Dawley | 2010 |
[Effects of Xuefu Zhuyu decoction on serum asymmetric dimethylarginine in atherosclerosis rabbits].
Topics: Animals; Arginine; Atherosclerosis; Cholesterol; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Male; Rabbits; Random Allocation; Triglycerides | 2009 |
The ADMA/DDAH pathway regulates VEGF-mediated angiogenesis.
Topics: Amidohydrolases; Animals; Apoptosis; Arginine; Cell Adhesion Molecules; Cell Polarity; Cell Proliferation; Cells, Cultured; Chemotaxis; Endothelial Cells; Focal Adhesions; Humans; In Vitro Techniques; Mice; Mice, Knockout; Microfilament Proteins; Neovascularization, Physiologic; Neuropeptides; Nitric Oxide; Phosphoproteins; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Signal Transduction; Vascular Endothelial Growth Factor A | 2009 |
Association of homocysteine, asymmetric dimethylarginine, and nitric oxide with preeclampsia.
Topics: Arginine; Biomarkers; Case-Control Studies; Chromatography, Liquid; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Nitric Oxide; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Third; Tandem Mass Spectrometry | 2010 |
Dimethylarginine dimethylaminohydrolase-1 transgenic mice are not protected from ischemic stroke.
Topics: Amidohydrolases; Animals; Arginine; Brain; Endothelium, Vascular; Genotype; Infarction, Middle Cerebral Artery; Ischemia; Male; Mice; Mice, Transgenic; Models, Biological; Nitric Oxide; Stroke | 2009 |
Role of asymmetric-dimethyl-L-arginine (ADMA) and nitrite/nitrate (NOx) in the pathogenesis of oxidative stress in female subjects with uncomplicated type 1 diabetes mellitus.
Topics: Adult; Arginine; Blood Glucose; Blood Specimen Collection; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 1; Feeding Behavior; Female; Glycated Hemoglobin; Humans; Nitrates; Nitrites; Oxidative Stress; Reference Values; Uric Acid | 2009 |
Asymmetrical dimethylarginine is associated with renal and cardiovascular outcomes and all-cause mortality in renal transplant recipients.
Topics: Adult; Arginine; Cardiovascular Diseases; Graft Rejection; Humans; Kidney Diseases; Kidney Transplantation; Middle Aged; Randomized Controlled Trials as Topic; Survival Rate; Treatment Outcome | 2010 |
Asymmetric dimethylarginine: understanding the physiology, genetics, and clinical relevance of this novel biomarker. Proceedings of the 4th International Symposium on ADMA.
Topics: Arginine; Austria; Biomarkers; Cardiovascular Diseases; Humans; Internationality; Nitric Oxide | 2009 |
Distribution of asymmetric dimethylarginine among 980 healthy, older adults of different ethnicities.
Topics: Aged; Arginine; Asian People; Black People; Cardiovascular Diseases; Cystatin C; Enzyme-Linked Immunosorbent Assay; Female; Glomerular Filtration Rate; Hispanic or Latino; Humans; Male; Middle Aged; Regression Analysis; Risk Factors; White People | 2010 |
Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2.
Topics: Amidohydrolases; Arginine; Blotting, Western; Cells, Cultured; Chromatin; Chromatography, High Pressure Liquid; DNA Primers; Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoprecipitation; Lentivirus; Nitrites; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2; Transfection | 2010 |
Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1-deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine.
Topics: Acetylcholine; Amidohydrolases; Animals; Aorta; Arginine; Brain; Cholinergic Agents; Endothelium, Vascular; Female; Hypertension; Kidney; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Nitric Oxide; Vasodilation; Ventricular Function, Left | 2009 |
A click chemistry mediated in vivo activity probe for dimethylarginine dimethylaminohydrolase.
Topics: Amidohydrolases; Arginine; Cell Line; Humans; Molecular Structure; Substrate Specificity | 2009 |
ADMA concentration changes across the menstrual cycle and during oral contraceptive use: the Cardiovascular Risk in Young Finns Study.
Topics: Adult; Arginine; Atherosclerosis; Brachial Artery; C-Reactive Protein; Contraceptives, Oral; Creatinine; Estrogens; Female; Finland; Humans; Menstrual Cycle; Progesterone Congeners; Prospective Studies; Risk Factors; Vasodilation; Young Adult | 2010 |
Asymmetric dimethylarginine damages connexin43-mediated endothelial gap junction intercellular communication.
Topics: Amidohydrolases; Animals; Arginine; Cell Communication; Cells, Cultured; Connexin 43; Endothelial Cells; Enzyme Inhibitors; Fluorescence Recovery After Photobleaching; Gap Junctions; Humans; Lysophosphatidylcholines; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Signal Transduction | 2009 |
Serum ADMA concentration-- an independent factor determining FMD impairment in cardiac syndrome X.
Topics: Aged; Arginine; Biomarkers; Carotid Arteries; Case-Control Studies; Endothelium, Vascular; Female; Humans; Male; Microvascular Angina; Middle Aged; Nitric Oxide; Nitroglycerin; Tunica Intima; Ultrasonography; Vasodilation | 2009 |
Dimethylarginines: their vascular and metabolic roles in Africans and Caucasians.
Topics: Adult; Age Factors; Aged; Arginine; Black People; Blood Flow Velocity; Blood Glucose; Blood Pressure; Blood Vessels; Cross-Sectional Studies; Female; Humans; Insulin; Insulin Resistance; Male; Middle Aged; Patient Selection; Pulsatile Flow; Regression Analysis; Sex Factors; South Africa; Vascular Resistance; White People | 2010 |
Increased serum asymmetric dimethylarginine levels in primary dysmenorrhea.
Topics: Adolescent; Adult; Arginine; Biomarkers; Body Mass Index; C-Reactive Protein; Cholesterol, LDL; Cohort Studies; Dysmenorrhea; Endothelium, Vascular; Female; Humans; Ischemia; Nitric Oxide; Pelvic Pain; Sensitivity and Specificity; Triglycerides; Uterus; Young Adult | 2010 |
Association between plasma asymmetrical dimethylarginine activity and saphenous vein graft disease in patients with coronary bypass.
Topics: Aged; Arginine; Biomarkers; Coronary Angiography; Coronary Artery Bypass; Enzyme-Linked Immunosorbent Assay; Female; Graft Occlusion, Vascular; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Platelet Count; Predictive Value of Tests; Risk Assessment; Risk Factors; Saphenous Vein; Up-Regulation; Vascular Patency | 2010 |
Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphisms.
Topics: Alleles; Amidohydrolases; Arginine; Case-Control Studies; Cohort Studies; Cross-Sectional Studies; Enzyme Inhibitors; Female; Gene Frequency; Genetic Variation; Genotype; Glomerular Filtration Rate; Humans; Kidney Failure, Chronic; Longitudinal Studies; Male; Polymorphism, Genetic; RNA, Messenger | 2010 |
Growth differentiation factor 15 and coronary collateral formation.
Topics: Aged; Analysis of Variance; Arginine; Collateral Circulation; Coronary Angiography; Coronary Artery Disease; Coronary Circulation; Coronary Stenosis; Cross-Sectional Studies; Female; Growth Differentiation Factor 15; Humans; Male; Middle Aged; Prognosis; Statistics, Nonparametric; Vascular Endothelial Growth Factor Receptor-1 | 2010 |
Asymmetric dimethylarginine in angiotensin II-induced hypertension.
Topics: Amidohydrolases; Angiotensin II; Animals; Arginine; Blood Pressure; Fibrosis; Hypertension, Renal; Kidney Cortex; Male; NADPH Oxidases; Nitrates; Nitrites; Oxidative Stress; Protein-Arginine N-Methyltransferases; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Vasoconstrictor Agents | 2010 |
Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production.
Topics: Adenoviridae; Animals; Arginine; Atherosclerosis; Chlorocebus aethiops; Citrulline; COS Cells; Diabetes Mellitus; Endothelial Cells; Gene Expression; Heart Failure; Humans; Hydrolysis; Hypertension; Kidney; Liver; Mice; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Transaminases; Transduction, Genetic | 2010 |
Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia.
Topics: Acetylcholine; Amidohydrolases; Animals; Arginine; Arterioles; Carotid Artery Thrombosis; Cerebral Arterial Diseases; Diet; Folic Acid Deficiency; Humans; Hyperhomocysteinemia; Hypertrophy; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Papaverine; Vasodilation; Vasodilator Agents | 2010 |
Ethylene glycol induced hyperoxaluria increases plasma and renal tissue asymmetrical dimethylarginine in rats: a new pathogenetic link in hyperoxaluria induced disorders.
Topics: Animals; Arginine; Ethylene Glycol; Hyperoxaluria; Rats; Rats, Sprague-Dawley; Tissue Distribution; Verapamil | 2010 |
Asymmetric dimethylarginine (ADMA) is present in plasma proteins of healthy subjects at the low nmol-per-g-level.
Topics: Arginine; Blood Proteins; Enzyme Inhibitors; Female; Humans; Male | 2010 |
Asymmetric dimethylarginine (ADMA) as a possible risk marker for ischemic stroke.
Topics: Age Factors; Aged; Arginine; Biomarkers; Blood Glucose; Brain Ischemia; Cholesterol, LDL; Dyslipidemias; Female; Humans; Hypertension; Male; Middle Aged; Nitric Oxide; Predictive Value of Tests; Risk Factors; Sensitivity and Specificity; Stroke; Up-Regulation | 2010 |
Arginine methylation of vasa protein is conserved across phyla.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Arginine; Argonaute Proteins; Cell Cycle Proteins; DEAD-box RNA Helicases; Drosophila melanogaster; Drosophila Proteins; Female; Gene Expression Regulation, Enzymologic; Humans; Male; Methylation; Mice; Oogenesis; Phylogeny; Protein Methyltransferases; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Proteins; Ribonucleoproteins; Ribonucleoproteins, Small Nuclear; Spermatogenesis; Xenopus laevis; Xenopus Proteins | 2010 |
Assessment of the relationship between asymmetric dimethylarginine and severity of erectile dysfunction and coronary artery disease.
Topics: Arginine; Coronary Artery Disease; Erectile Dysfunction; Humans; Male; Middle Aged; Severity of Illness Index; Surveys and Questionnaires | 2010 |
A novel predictor of restenosis and adverse cardiac events: asymmetric dimethylarginine.
Topics: Aged; Angioplasty, Balloon, Coronary; Arginine; Biomarkers; C-Reactive Protein; Coronary Angiography; Coronary Restenosis; Coronary Stenosis; Female; Humans; Male; Metals; Middle Aged; Natriuretic Peptide, Brain; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Prosthesis Design; Protein Precursors; Risk Assessment; Risk Factors; Stents; Time Factors; Treatment Outcome | 2010 |
Asymmetric dimethylarginine, an endogenous NO synthase inhibitor, in human breast milk.
Topics: Arginine; Enzyme Inhibitors; Female; Gestational Age; Humans; Infant, Newborn; Male; Milk, Human; Nitric Oxide; Nitric Oxide Synthase; Postpartum Period | 2010 |
Effect of aspirin on high glucose-induced senescence of endothelial cells.
Topics: Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Aspirin; Caveolin 1; Cells, Cultured; Cellular Senescence; Chromatography, High Pressure Liquid; Endothelial Cells; Flow Cytometry; Glucose; Humans; Immunoblotting; Immunoprecipitation; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Propane; Reactive Oxygen Species | 2009 |
Inflammatory/oxidative stress during the first week after different types of cardiac surgery.
Topics: Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Coronary Artery Bypass; Female; Heart Valve Prosthesis Implantation; Homocysteine; Humans; Inflammation; Inflammation Mediators; Interleukin-6; Male; Middle Aged; Oxidative Stress; Peroxidase; Time Factors; Treatment Outcome | 2010 |
Increased levels of asymmetric dimethylarginine and C-reactive protein are associated with impaired vascular reactivity in essential hypertension.
Topics: Adult; Aged; Arginine; Blood Flow Velocity; Brachial Artery; C-Reactive Protein; Female; Humans; Hypertension; Inflammation; Male; Middle Aged; Vasodilation | 2010 |
A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease.
Topics: Aged; Amidohydrolases; Arginine; Asian People; Binding Sites; Biomarkers; Case-Control Studies; Cells, Cultured; Chi-Square Distribution; China; Coronary Artery Disease; DNA Mutational Analysis; DNA-Binding Proteins; Female; Gene Expression Regulation, Enzymologic; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Mutagenesis, Insertional; Odds Ratio; Phenotype; Polymorphism, Genetic; Promoter Regions, Genetic; Risk Assessment; Risk Factors; Sequence Deletion; Stroke; Thrombosis; Transcription Factor MTF-1; Transcription Factors; Transcriptional Activation; Transfection | 2010 |
Circulating angiopoietin-2 levels increase with progress of chronic kidney disease.
Topics: Adult; Aged; Angiopoietin-2; Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Chronic Disease; Disease Progression; Female; Glomerular Filtration Rate; Humans; Kidney Diseases; Male; Middle Aged; Nephrectomy; Risk Factors; Tissue Donors | 2010 |
Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype.
Topics: Adult; Albuminuria; Anemia, Sickle Cell; Arginine; beta-Thalassemia; Cholelithiasis; Female; Hemolysis; Humans; Hypertension, Pulmonary; Leg Ulcer; Male; Middle Aged; Nitric Oxide; Osteonecrosis; Phenotype; Priapism; Retinal Diseases; Sickle Cell Trait; Young Adult | 2010 |
Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase.
Topics: Animals; Aorta, Thoracic; Arginine; Cattle; Cells, Cultured; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Endothelial Cells; Glycation End Products, Advanced; Hypoglycemic Agents; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Vascular Diseases; Vasodilation; Vasodilator Agents | 2010 |
ADMA, C-reactive protein, and albuminuria in untreated essential hypertension: a cross-sectional study.
Topics: Adult; Albuminuria; Arginine; Blood Pressure; C-Reactive Protein; Creatinine; Cross-Sectional Studies; Endothelium, Vascular; Female; Humans; Hypertension; Inflammation; Male; Middle Aged; Regression Analysis; Serum Albumin | 2010 |
Early detection of cardiac involvement in systemic sclerosis assessed by tissue-Doppler echocardiography: relationship with neurohormonal activation and endothelial dysfunction.
Topics: Adult; Aged; Analysis of Variance; Arginine; Blood Flow Velocity; Echocardiography, Doppler; Endothelium, Vascular; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Myocardial Contraction; Natriuretic Peptide, Brain; Peptide Fragments; Prospective Studies; Scleroderma, Systemic; Ventricular Dysfunction, Left | 2010 |
Effects of stent implementation on plasma levels of asymmetric dimethylarginine in patients with or without ST-segment elevation acute myocardial infarction.
Topics: Angioplasty, Balloon, Coronary; Arginine; Case-Control Studies; Coronary Angiography; Female; Humans; Male; Methylation; Middle Aged; Myocardial Infarction; Ornithine; Stents; Ultrasonography | 2010 |
Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes.
Topics: Aged; Amidohydrolases; Arginine; Diabetes Mellitus, Type 2; Female; Gene Expression Regulation; Genotype; Haplotypes; Humans; Male; Mass Spectrometry; Middle Aged; Polymorphism, Genetic | 2010 |
Melatonin prevents increased asymmetric dimethylarginine in young rats with bile duct ligation.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arginine; Bile Ducts; Cholestasis, Intrahepatic; Disease Models, Animal; Immunohistochemistry; Kidney; Liver; Male; Melatonin; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2010 |
Adenoviral-mediated overexpression of DDAH improves vascular tone regulation.
Topics: Adenoviridae; Amidohydrolases; Animals; Arginine; Carotid Arteries; Endothelial Cells; Gene Expression; Genetic Therapy; Green Fluorescent Proteins; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Peripheral Arterial Disease; Umbilical Veins; Vasoconstriction | 2010 |
Effect of uric acid on coronary microvascular endothelial function in women: association with eGFR and ADMA.
Topics: Aged; Angiography; Arginine; Endothelium, Vascular; Female; Glomerular Filtration Rate; Hemodynamics; Humans; Male; Microcirculation; Middle Aged; Oxidative Stress; Risk Factors; Sex Factors; Uric Acid | 2010 |
Effects of long-term disease-modifying antirheumatic drugs on endothelial function in patients with early rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arginine; Arthritis, Rheumatoid; Biomarkers; Carotid Artery, Common; Case-Control Studies; Coronary Circulation; Coronary Vessels; Echocardiography, Doppler; Endothelium, Vascular; Female; Humans; Italy; Male; Methotrexate; Microcirculation; Middle Aged; Severity of Illness Index; Time Factors; Treatment Outcome | 2010 |
Reduced proteinuria using ramipril in diabetic CKD stage 1 decreases circulating cell death receptor activators concurrently with ADMA. A novel pathophysiological pathway?
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Arginine; Chronic Disease; Diabetic Nephropathies; fas Receptor; Female; Humans; Kidney Diseases; Male; Middle Aged; Multivariate Analysis; Myostatin; Proteinuria; Ramipril | 2010 |
Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine.
Topics: Amidohydrolases; Animals; Aorta; Apolipoproteins E; Arginine; Atherosclerosis; Blood Pressure; Cardiovascular Diseases; Humans; Male; Mice; Mice, Transgenic; Models, Genetic; Nitric Oxide; Risk | 2010 |
Down but not out: candidate gene-based studies still have value in a world dominated by whole genome approaches.
Topics: Amidohydrolases; Arginine; Asian People; Biomarkers; China; Coronary Artery Disease; Evidence-Based Medicine; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Phenotype; Polymorphism, Genetic; Promoter Regions, Genetic; Risk Factors; Stroke; Thrombosis | 2010 |
Massive quantities of asymmetric dimethylarginine (ADMA) are incorporated in red blood cell proteins and may be released by proteolysis following hemolytic stress.
Topics: Anemia, Sickle Cell; Arginine; Blood Proteins; Erythrocytes; Hemolysis; Humans | 2010 |
The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels.
Topics: Aged; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Arginine; China; Coronary Artery Disease; Endothelium, Vascular; Female; Glutamic Acid; Humans; Lysine; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic; Risk Factors | 2010 |
ADMA is a correlate of insulin resistance in early-stage diabetes independent of hs-CRP and body adiposity.
Topics: Adiposity; Adult; Arginine; Biomarkers; Blood Glucose; C-Reactive Protein; Case-Control Studies; Cholesterol, HDL; Cholesterol, LDL; Creatinine; Diabetes Mellitus, Type 2; Fasting; Homeostasis; Humans; Inflammation; Insulin Resistance; Male; Middle Aged; Triglycerides | 2010 |
Correlation between plasma asymmetric dimethylarginine and different types of coronary heart disease.
Topics: Acute Coronary Syndrome; Aged; Angina Pectoris; Arginine; Biomarkers; Coronary Disease; Female; Humans; Male; Middle Aged; Nitric Oxide; von Willebrand Factor | 2010 |
Association between exaggerated blood pressure response to exercise and serum asymmetric dimethylarginine levels.
Topics: Adult; Arginine; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cardiovascular Diseases; Case-Control Studies; Chromatography, High Pressure Liquid; Exercise; Exercise Test; Female; Humans; Hypertension; Male; Middle Aged; Predictive Value of Tests | 2010 |
Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers.
Topics: Anthracenes; Arginine; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Line, Tumor; DNA Replication; Enzyme-Linked Immunosorbent Assay; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Neoplasms; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Propane; Protein-Arginine N-Methyltransferases; Repressor Proteins; RNA, Small Interfering; Urinary Bladder Neoplasms | 2011 |
Effects of angiotensin type 1 receptor blockade on arginine and ADMA synthesis and metabolic pathways in fawn-hooded hypertensive rats.
Topics: Amidohydrolases; Angiotensin II Type 1 Receptor Blockers; Animals; Arginine; Biphenyl Compounds; Citrulline; Hypertension; Irbesartan; Male; Metabolic Networks and Pathways; Nitric Oxide; Rats; Tetrazoles | 2010 |
Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism.
Topics: Angiogenesis Inhibitors; Arginine; Coronary Artery Disease; Gene Expression Regulation; Humans; MicroRNAs; Neovascularization, Pathologic; Stem Cells | 2010 |
Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics.
Topics: Arginine; Biomarkers; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Embryonic Stem Cells; Forecasting; Humans; Metabolomics; Models, Statistical; Teratogens; Toxicity Tests | 2010 |
Plasma apelin and ADMA Levels in patients with essential hypertension.
Topics: Adult; Apelin; Arginine; Biomarkers; Blood Pressure; Body Mass Index; Case-Control Studies; Endothelium, Vascular; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Hypertension; Intercellular Signaling Peptides and Proteins; Male; Statistics, Nonparametric; Young Adult | 2010 |
[Prevalence of cardiovascular disease in uraemia and relevance of cardiovascular risk factors].
Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Blood Proteins; Cardiovascular Diseases; Comorbidity; Cross-Sectional Studies; Diabetes Complications; Female; Humans; Hyperhomocysteinemia; Hyperlipidemias; Kidney Transplantation; Male; Middle Aged; Postoperative Complications; Prevalence; Risk Factors; Smoking; Stroke Volume; Ultrasonography; Uremia | 2010 |
Left atrial volume and N-terminal pro-B type natriuretic peptide are associated with elevated pulmonary artery pressure in patients with systemic sclerosis.
Topics: Aged; Arginine; Biomarkers; Blood Pressure; Cross-Sectional Studies; Female; Follow-Up Studies; Heart Atria; Humans; Hypertension, Pulmonary; Male; Middle Aged; Multivariate Analysis; Natriuretic Peptide, Brain; Peptide Fragments; Predictive Value of Tests; Prospective Studies; Pulmonary Artery; Scleroderma, Systemic; Ultrasonography; Ventricular Dysfunction, Right | 2010 |
Neuroprotective effect of asymmetric dimethylarginine against 1-methyl-4-phenylpyridinium ion-induced damage in PC12 cells.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Arginine; Cell Culture Techniques; Cell Survival; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; PC12 Cells; Rats; Reactive Oxygen Species | 2010 |
HPLC determination of plasma dimethylarginines: method validation and preliminary clinical application.
Topics: Adolescent; Adult; Aged; Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Creatine; Endothelium, Vascular; Female; Glomerular Filtration Rate; Humans; Kidney Function Tests; Male; Middle Aged; Renal Insufficiency, Chronic; Young Adult | 2010 |
Relationships between dimethylarginine and the presence of vertebral fractures in type 2 diabetes mellitus.
Topics: Adult; Aged; Arginine; Bone Density; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Risk Factors; Spinal Fractures | 2010 |
The role of the DDAH-ADMA pathway in the protective effect of resveratrol analog BTM-0512 on gastric mucosal injury.
Topics: Amidohydrolases; Animals; Anti-Ulcer Agents; Arginine; Disease Models, Animal; Ethanol; Hydroxyl Radical; Male; Molecular Structure; Nitric Oxide; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Stomach Ulcer; Superoxides | 2010 |
Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma.
Topics: Airway Remodeling; Animals; Arginine; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Chronic Disease; Disease Models, Animal; Epithelial Cells; Epithelium; Lung; Male; Mice; Mice, Inbred BALB C; Mucus; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrosation; Pneumonia; Simvastatin; Stress, Physiological | 2011 |
Interethnic differences in ADMA concentrations and negative association with nitric oxide formation in preeclampsia.
Topics: Adult; Arginine; Biomarkers; Black People; Case-Control Studies; Ethnicity; Female; Humans; Nitric Oxide; Nitrites; Pre-Eclampsia; Pregnancy; White People; Young Adult | 2010 |
Differential sensitivity of basal and acetylcholine-induced activity of nitric oxide to blockade by asymmetric dimethylarginine in the rat aorta.
Topics: Acetylcholine; Animals; Aorta; Arginine; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Nitric Oxide; omega-N-Methylarginine; Phenylephrine; Rats; Rats, Wistar | 2010 |
Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and plasma concentrations of asymmetric dimethylarginine in Turkish pre-eclamptic women without fetal growth retardation.
Topics: Adult; Analysis of Variance; Arginine; Chromatography, High Pressure Liquid; Female; Fetal Growth Retardation; Genetic Association Studies; Genotype; Humans; Nitric Oxide Synthase Type III; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Pre-Eclampsia; Pregnancy; Turkey | 2010 |
Alpha-lipoic acid activates dimethylarginine dimethylaminohydrolase in cultured endothelial cells.
Topics: Amidohydrolases; Animals; Arginine; Cell Line, Tumor; Endothelial Cells; Enzyme Induction; Mice; Promoter Regions, Genetic; STAT3 Transcription Factor; Thioctic Acid | 2010 |
FGF-23 and vascular dysfunction in patients with stage 3 and 4 chronic kidney disease.
Topics: Adult; Arginine; Chronic Disease; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Forearm; Humans; Kidney Diseases; Linear Models; Male; Middle Aged; Multivariate Analysis; Nitric Oxide; Risk Factors; Vasodilation | 2010 |
A miR-thless perspective: how asymmetric dimethylarginine impairs the functions of angiogenic progenitor cells.
Topics: Angiogenesis Inhibitors; Animals; Arginine; Humans; MicroRNAs; Risk Factors; Stem Cells | 2010 |
Increased production of asymmetric dimethylarginine (ADMA) in ankylosing spondylitis: association with other clinical and laboratory parameters.
Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Female; Humans; Male; Middle Aged; Osteoarthritis, Hip; Osteoarthritis, Knee; Risk Factors; Spondylitis, Ankylosing | 2011 |
Antiretrovirals induce endothelial dysfunction via an oxidant-dependent pathway and promote neointimal hyperplasia.
Topics: Animals; Anti-HIV Agents; Arginine; Atherosclerosis; Biomarkers; Cell Proliferation; Drug Therapy, Combination; Endothelium, Vascular; Free Radical Scavengers; Hyperplasia; Indinavir; Male; Metalloporphyrins; Mice; Mice, Inbred C57BL; Neointima; Zidovudine | 2010 |
Adipokines, endothelial dysfunction and nutritional status in peritoneal dialysis patients.
Topics: Adiponectin; Adult; Aged; Aldehydes; Arginine; Biomarkers; Body Mass Index; Body Weight; C-Reactive Protein; Cardiovascular Diseases; Endothelium; Female; Humans; Inflammation; Interleukin-6; Leptin; Lipoproteins, LDL; Male; Malnutrition; Malondialdehyde; Middle Aged; Nutritional Status; Oxidative Stress; Peritoneal Dialysis; Risk Factors; Tumor Necrosis Factor-alpha | 2010 |
Association between plasma asymmetrical dimethylarginine activity and severity of aortic valve stenosis.
Topics: Aged; Aortic Valve Stenosis; Arginine; Biomarkers; Chi-Square Distribution; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Predictive Value of Tests; Severity of Illness Index; Turkey; Up-Regulation | 2011 |
Asymmetric dimethylarginine in hemodialysis, hemodiafiltration, and peritoneal dialysis.
Topics: Aged; Arginine; Female; Glycation End Products, Advanced; Homocysteine; Humans; Male; Middle Aged; Oxidative Stress; Peritoneal Dialysis; Renal Dialysis | 2010 |
Immunoregulatory effects of the flavonol quercetin in vitro and in vivo.
Topics: Adult; Animals; Anti-Inflammatory Agents; Apoptosis; Arginine; Cell Adhesion; Cell Differentiation; Cell Line; Dendritic Cells; Endocytosis; Endothelial Cells; Humans; Leukocytes; Lipoproteins, LDL; Male; Mice; Mice, Inbred C57BL; Monocytes; NF-kappa B; Quercetin; Up-Regulation | 2011 |
Levels of asymmetrical dimethylarginine are predictive of brachial artery flow-mediated dilation 6 years later. The Cardiovascular Risk in Young Finns Study.
Topics: Adult; Arginine; Brachial Artery; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Cohort Studies; Endothelium, Vascular; Female; Finland; Humans; Male; Middle Aged; Multivariate Analysis; Risk Factors | 2010 |
Modulatory role of the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine (ADMA), in morphine tolerance and dependence in mice.
Topics: Animals; Arginine; Chromatography, High Pressure Liquid; Drug Tolerance; Homoarginine; Male; Mice; Mice, Inbred BALB C; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Pain Measurement | 2010 |
Predictors of the intima-media thickness of carotid artery in asymptomatic newly detected severe hypercholesterolemic patients.
Topics: Adult; Age Factors; Arginine; Biomarkers; Bulgaria; Carotid Arteries; Carotid Artery Diseases; Case-Control Studies; Cell Adhesion Molecules; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Homocysteine; Humans; Hypercholesterolemia; Linear Models; Lipids; Male; Predictive Value of Tests; Risk Assessment; Risk Factors; Severity of Illness Index; Tunica Intima; Tunica Media; Ultrasonography | 2010 |
The DDAH-ADMA pathway. Proceedings of the 4th International Symposium on ADMA. August 28-30, 2008. Bregenz, Austria.
Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Humans | 2009 |
Evaluation of asymmetric dimethylarginine, nitric oxide levels and associated independent variables in obese and lean patients with polycystic ovarian syndrome.
Topics: Adolescent; Adult; Arginine; Biomarkers; Blood Glucose; Cardiovascular Diseases; Cholesterol; Female; Hormones; Humans; Nitric Oxide; Obesity; Polycystic Ovary Syndrome; Risk Factors; Young Adult | 2011 |
Angiotensin II and NADPH oxidase increase ADMA in vascular smooth muscle cells.
Topics: Analysis of Variance; Angiotensin II; Animals; Arginine; Benzimidazoles; Biphenyl Compounds; Blotting, Western; Cells, Cultured; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Rats; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Tetrazoles | 2010 |
Bile duct ligation in developing rats: temporal progression of liver, kidney, and brain damage.
Topics: Animals; Arginine; Bile Ducts; Brain; Brain Diseases; Cholestasis; Disease Progression; End Stage Liver Disease; Kidney; Kidney Diseases; Laparotomy; Ligation; Lipocalins; Liver; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Time Factors | 2010 |
Do sea stars have low ADMA levels? High ADMA and low EPC count--duo infernal for the kidney.
Topics: Animals; Arginine; Cell Count; Chronic Disease; Endothelial Cells; Glomerular Filtration Rate; Humans; Kidney Diseases; Stem Cells | 2010 |
Impact of reversible myocardial ischaemia on nitric oxide and asymmetric dimethylarginine production in patients with high risk for coronary heart disease.
Topics: Arginine; Coronary Disease; Diabetes Complications; Exercise Tolerance; Female; Humans; Male; Middle Aged; Nitric Oxide; Risk Factors; Ultrasonography | 2010 |
Circulating levels of asymmetric dimethylarginine are an independent risk factor for left ventricular hypertrophy and predict cardiovascular events in pre-dialysis patients with chronic kidney disease.
Topics: Adult; Arginine; Female; Follow-Up Studies; Humans; Hypertrophy, Left Ventricular; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Prospective Studies; Renal Dialysis; Renal Insufficiency, Chronic; Risk Factors | 2010 |
Simultaneous quantitative determination of N(G),N(G)-dimethyl-L-arginine or asymmetric dimethylarginine and related pathway's metabolites in biological fluids by ultrahigh-performance liquid chromatography/electrospray ionization-tandem mass spectrometry.
Topics: Adult; Arginine; Body Fluids; Chromatography, High Pressure Liquid; Citrulline; Enzyme Inhibitors; Humans; Infant, Newborn; Middle Aged; Nitric Oxide; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2010 |
Impaired endothelial function and microvascular asymmetrical dimethylarginine in angiotensin II-infused rats: effects of tempol.
Topics: Analysis of Variance; Angiotensin II; Animals; Antioxidants; Arginine; Arterioles; Cyclic N-Oxides; Endothelium, Vascular; Male; Malondialdehyde; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Spin Labels; Vasoconstrictor Agents | 2010 |
Asymmetric dimethylarginine (ADMA) induces chronic kidney disease through a mechanism involving collagen and TGF-β1 synthesis.
Topics: Animals; Arginine; Collagen; Endothelin-1; Enzyme Inhibitors; Fibrosis; Gene Expression Regulation; Hypertension; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Renal Insufficiency, Chronic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta1 | 2011 |
The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism.
Topics: 3-Hydroxybutyric Acid; Animals; Arginine; Autophagy; Biomarkers; Breast Neoplasms; Caveolin 1; Female; Gene Expression Profiling; Humans; Mice; MicroRNAs; Models, Biological; Oxidative Stress; Stromal Cells | 2010 |
Relationship between L-arginine/asymmetric dimethylarginine, homocysteine, folic acid, vitamin B levels, and coronary artery ectasia.
Topics: Aged; Arginine; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Dilatation, Pathologic; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Prospective Studies; Turkey; Vitamin B Complex | 2010 |
Plasma levels of asymmetric dimethylarginine in patients with biopsy-proven nonalcoholic fatty liver disease.
Topics: Adult; Arginine; Biopsy; Blood Glucose; Chromatography, High Pressure Liquid; Fatty Liver; Female; Glomerular Filtration Rate; Humans; Insulin Resistance; Liver; Male; Middle Aged | 2011 |
Negative association of L-arginine methylation products with oocyte numbers.
Topics: Adult; Arginine; Female; Fertilization in Vitro; Follicular Fluid; Humans; Methylation; Oocytes; Ovulation Induction | 2010 |
C-terminus of heat shock protein 70-interacting protein-dependent GTP cyclohydrolase I degradation in lambs with increased pulmonary blood flow.
Topics: Animals; Anthracenes; Arginine; Blood Flow Velocity; Disease Models, Animal; Female; GTP Cyclohydrolase; Heart Defects, Congenital; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Lung; Nitric Oxide; Nitric Oxide Synthase; Propane; Proteasome Endopeptidase Complex; Sheep | 2011 |
Sequential change of asymmetric dimethylarginine levels after initiation of peritoneal dialysis in patients with end-stage renal disease.
Topics: Aged; Arginine; Biomarkers; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nutritional Status; Peritoneal Dialysis, Continuous Ambulatory; Time Factors; Treatment Outcome | 2010 |
Asymmetric dimethylarginine as a risk marker for early-onset ischemic stroke in Indian population.
Topics: Adolescent; Adult; Analysis of Variance; Arginine; Biomarkers; Brain Ischemia; Case-Control Studies; Female; Humans; India; Linear Models; Male; Middle Aged; Risk; Stroke; Time Factors; Young Adult | 2011 |
Transplantation of endothelial progenitor cells overexpressing endothelial nitric oxide synthase enhances inhibition of neointimal hyperplasia and restores endothelium-dependent vasodilatation.
Topics: Acetylcholine; Animals; Arginine; Bone Marrow Cells; Carotid Artery Injuries; Catheterization; Cell Differentiation; Cell Proliferation; Endothelial Cells; Humans; Hyperplasia; Lipoproteins, LDL; Male; Neointima; Nitric Oxide; Nitric Oxide Synthase Type III; Plant Lectins; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Stem Cells; Transfection; Vasodilation; von Willebrand Factor | 2011 |
Asymmetric dimethylarginine potentiates lung inflammation in a mouse model of allergic asthma.
Topics: Amidohydrolases; Animals; Arginine; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enzyme Inhibitors; Epithelial Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide Synthase Type II; Nitrites; Ovalbumin; Pneumonia; Respiratory Mucosa | 2010 |
The impact of rapid atrial pacing on ADMA and endothelial NOS.
Topics: Aged; Animals; Arginine; Atrial Fibrillation; Calcium-Binding Proteins; Disease Models, Animal; Endothelium, Vascular; Female; Heart Rate; Human Umbilical Vein Endothelial Cells; Humans; Male; Middle Aged; Myocardial Contraction; Nitric Oxide Synthase Type III; Oxidative Stress; Pacemaker, Artificial; Risk Factors; Swine; Tachycardia; Ventricular Function, Left | 2012 |
Acute lung injury-induced collagen deposition is associated with elevated asymmetric dimethylarginine and arginase activity.
Topics: Acute Lung Injury; Amidohydrolases; Animals; Arginase; Arginine; Blotting, Western; Collagen; Female; Lipid Peroxidation; Nitrates; Nitrites; Sheep | 2011 |
Plasma asymmetric dimethylarginine (ADMA) levels and atherosclerotic disease in ankylosing spondylitis: a cross-sectional study.
Topics: Adult; Arginine; Arteries; Atherosclerosis; Carotid Artery, Common; Cross-Sectional Studies; Electrophoresis, Capillary; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Risk Factors; Spondylitis, Ankylosing | 2011 |
Melatonin prevents hypertension and increased asymmetric dimethylarginine in young spontaneous hypertensive rats.
Topics: Analysis of Variance; Animals; Arginine; Blood Pressure; Blotting, Western; Body Weight; Citrulline; Histocytochemistry; Hypertension; Male; Melatonin; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Organ Size; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2010 |
Ramipril retards development of aortic valve stenosis in a rabbit model: mechanistic considerations.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic Valve; Aortic Valve Stenosis; Arginine; Carrier Proteins; Disease Models, Animal; Disease Progression; Echocardiography; Enzyme Inhibitors; Ergocalciferols; Humans; Male; Rabbits; Ramipril; Vitamins | 2011 |
Asymmetric dimethylarginine concentrations are elevated in women with gestational diabetes.
Topics: Adolescent; Adult; Arginine; C-Reactive Protein; Diabetes, Gestational; Female; Homocysteine; Humans; Insulin Resistance; Pregnancy; Pregnancy Trimester, Third; Young Adult | 2010 |
Chitotriosidase activity predicts endothelial dysfunction in type-2 diabetes mellitus.
Topics: Adult; Arginine; Diabetes Mellitus, Type 2; Endothelium; Female; Hexosaminidases; Humans; Male; Middle Aged; Young Adult | 2010 |
Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes.
Topics: Animals; Arginine; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Heart Failure; Humans; Mice; Mice, Knockout; MicroRNAs; Myocytes, Cardiac; Nitric Oxide Synthase Type III; Rats; STAT3 Transcription Factor; Ubiquitin-Conjugating Enzymes; Up-Regulation | 2011 |
Characterization of C-alkyl amidines as bioavailable covalent reversible inhibitors of human DDAH-1.
Topics: Amidines; Aminohydrolases; Arginine; Biological Availability; Calorimetry, Differential Scanning; Cell Line; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase | 2011 |
The alteration of asymmetric dimetilarginine (ADMA) levels in cardiac and gastrocnemius muscles following radioactive iodine application in guinea pigs and the effect of L-carnitine on this alteration.
Topics: Animals; Arginine; Carnitine; Guinea Pigs; Heart; Homoarginine; Iodine Radioisotopes; Male; Muscle, Skeletal; Myocardium; Radiation-Protective Agents; Thyroid Hormones | 2011 |
Serum asymmetric dimethylarginine levels in normotensive obese individuals.
Topics: Adult; Arginine; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Male; Middle Aged; Obesity; Risk Factors | 2010 |
Low levels of asymmetric dimethylarginine in children with diabetes mellitus type I compared with healthy children.
Topics: Adolescent; Arginine; Child; Child, Preschool; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Female; Glycated Hemoglobin; Humans; Lipoproteins, HDL; Male; Nitric Oxide Synthase; Oxidative Stress; Young Adult | 2011 |
The adipose tissue gene expression in mice with different nitric oxide availability.
Topics: Adipose Tissue; Adipose Tissue, Brown; Adipose Tissue, White; Amidohydrolases; Animals; Arginine; Female; Gene Expression; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III | 2010 |
[Plasma asymmetric dimethylarginine and cystatin C levels in patients with coronary artery disease].
Topics: Aged; Arginine; Case-Control Studies; Coronary Disease; Cystatin C; Female; Humans; Male; Middle Aged | 2010 |
[Asymmetric dimethylarginine (ADMA) in children with diabetes type 1].
Topics: Adolescent; Adult; Arginine; Biomarkers; Child; Comorbidity; Diabetes Mellitus, Type 1; Endothelium, Vascular; Female; Humans; Hypertension; Male; Nitric Oxide Synthase; Young Adult | 2010 |
Association of asymmetric dimethylarginine with severity of kidney injury and decline in kidney function in IgA nephropathy.
Topics: Adult; Arginine; Case-Control Studies; Chronic Disease; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Glomerulonephritis, IGA; Humans; Kidney; Kidney Function Tests; Male; Regression Analysis; Retrospective Studies; Smoking | 2011 |
Posttranslational arginine methylation of lamin A/C during myoblast fusion.
Topics: Amino Acid Sequence; Animals; Arginine; Blotting, Western; Cell Differentiation; Cells, Cultured; Electrophoresis, Gel, Two-Dimensional; Lamin Type A; Membrane Fusion; Methylation; Molecular Sequence Data; Muscle Development; Muscle Fibers, Skeletal; Myoblasts, Skeletal; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2011 |
Dimethylarginines and serotonin in the blood of spontaneously hypertensive rats.
Topics: Animals; Arginine; Hydroxyindoleacetic Acid; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Wistar; Serotonin | 2009 |
Nitric oxide synthase inhibitors and cerebral vasospasm.
Topics: Animals; Arginine; Citrulline; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; S-Adenosylmethionine; Vasospasm, Intracranial | 2011 |
Down syndrome patients with pulmonary hypertension have elevated plasma levels of asymmetric dimethylarginine.
Topics: Arginine; Biomarkers; Down Syndrome; Female; Humans; Hypertension, Pulmonary; Infant; Male; Nitrates; Nitrites | 2011 |
Asymmetric dimethylarginine levels in essential thrombocythemia--a retrospective analysis.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Body Mass Index; Cohort Studies; Disease Progression; Humans; Middle Aged; Retrospective Studies; Thrombocythemia, Essential; Young Adult | 2011 |
Asymmetric dimethylarginine as a risk factor for cardiovascular disease in Japanese patients with type 2 diabetes mellitus.
Topics: Aged; Arginine; Asian People; Cardiovascular Diseases; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Regression Analysis; Risk Factors | 2011 |
Asymmetric dimethylarginine in ELBW newborns exposed to chorioamnionitis.
Topics: Arginine; Chorioamnionitis; Female; Gestational Age; Humans; Infant, Extremely Low Birth Weight; Infant, Newborn; Male; Osmolar Concentration; Pregnancy; Prenatal Exposure Delayed Effects | 2011 |
Serum asymmetric dimethylarginine (ADMA), homocysteine, vitamin B(12), folate levels, and lipid profiles in epileptic children treated with valproic acid.
Topics: Adolescent; Anticonvulsants; Arginine; Biomarkers; Case-Control Studies; Child; Child, Preschool; Cholesterol; Cross-Sectional Studies; Drug Administration Schedule; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Triglycerides; Valproic Acid; Vitamin B 12; Vitamin B Complex | 2011 |
Association between asymmetric dimethylarginine and indices of vascular function in patients with essential hypertension.
Topics: Adult; Arginine; Cardiovascular System; Endothelium, Vascular; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nitric Oxide Synthase; Regression Analysis; Tunica Intima | 2011 |
Asymmetric dimethylarginine in normotensive pregnant women with isolated fetal intrauterine growth restriction: a comparison with preeclamptic women with and without intrauterine growth restriction.
Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Female; Fetal Growth Retardation; Humans; Pre-Eclampsia; Pregnancy | 2011 |
Time course of asymmetric dimethylarginine (ADMA) and oxidative stress in fructose-hypertensive rats: a model related to metabolic syndrome.
Topics: Animals; Aorta; Arginine; Blood Glucose; Blood Pressure; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fructose; Heart Rate; Hypertension; Male; Metabolic Syndrome; NADPH Oxidases; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents | 2011 |
Urinary asymmetric dimethylarginine (ADMA) is a predictor of mortality risk in patients with coronary artery disease.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Predictive Value of Tests; Risk Factors | 2012 |
Plasma dimethylarginines during the acute inflammatory response.
Topics: Acute-Phase Reaction; Aged; Aged, 80 and over; Arginine; Arthroplasty, Replacement, Knee; Cohort Studies; Dimethylamines; Enzyme Inhibitors; Female; Humans; Inflammation; Knee Joint; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Postoperative Complications | 2011 |
Asymmetric dimethylarginine as an independent risk marker for mortality in ambulatory patients with peripheral arterial disease.
Topics: Aged; Arginine; Biomarkers; Cardiovascular Diseases; Cerebrovascular Disorders; Enzyme Inhibitors; Epidemiologic Methods; Female; Germany; Humans; Male; Nitric Oxide Synthase; Peripheral Arterial Disease; Prognosis | 2011 |
Asymmetric dimethylarginine upregulates the expression of ACAT-1 in THP-1 macrophage-derived foam cells.
Topics: Acetyl-CoA C-Acetyltransferase; Arginine; Cell Line; Cholesterol; Foam Cells; Humans; Macrophages; Monocytes; RNA, Messenger; Up-Regulation | 2010 |
Serum paraoxonase 1 activity, asymmetric dimethylarginine levels, and brachial artery flow-mediated dilatation in women with polycystic ovary syndrome.
Topics: Adult; Arginine; Aryldialkylphosphatase; Biomarkers; Blood Flow Velocity; Brachial Artery; Case-Control Studies; Endothelium, Vascular; Female; Hormones; Humans; Polycystic Ovary Syndrome; Prospective Studies; Risk Factors; Ultrasonography; Vasodilation; Young Adult | 2011 |
The effects of endothelial dysfunction and inflammation on slow coronary flow.
Topics: Arginine; Blood Flow Velocity; C-Reactive Protein; Case-Control Studies; Coronary Angiography; Coronary Vessels; Dilatation, Pathologic; Endothelium, Vascular; Female; Humans; Inflammation; Logistic Models; Male; Middle Aged; No-Reflow Phenomenon; Ultrasonography | 2010 |
Dimethylarginine dimethylaminohydrolase 1 modulates endothelial cell growth through nitric oxide and Akt.
Topics: Amidohydrolases; Animals; Arginine; Cell Movement; Cell Proliferation; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Humans; Mice; Mice, Knockout; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; ras Proteins; RNA Interference; Signal Transduction; Time Factors; Tissue Culture Techniques; Transfection | 2011 |
3,4,5,6-Tetrahydroxyxanthone preserves intercellular communication by reduction of the endogenous nitric oxide synthase inhibitor level.
Topics: Arginine; Cell Survival; Connexin 43; Lysophosphatidylcholines; Molecular Structure; Nitric Oxide Synthase; Reactive Oxygen Species; Xanthones | 2011 |
Effect of asymmetric dimethylarginine on MIF expression and TNF-α and IL-8 secretion in THP-1 monocytes-derived macrophages.
Topics: Arginine; Cell Differentiation; Cell Line; Humans; Interleukin-8; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Macrophages; Monocytes; Phenanthrenes; RNA, Messenger; Tumor Necrosis Factor-alpha | 2011 |
Elevated concentrations of Nɛ-homocysteinyl-lysine isopeptide in acute myocardial infarction: links with ADMA formation.
Topics: Arginine; Autoantibodies; Dipeptides; Endothelium; Female; Fibrinolysis; Humans; Male; Middle Aged; Myocardial Infarction; Oxidative Stress; Thrombin | 2011 |
Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with cystic fibrosis.
Topics: Adolescent; Airway Obstruction; Arginine; Child; Chromatography, Liquid; Cystic Fibrosis; Female; Humans; Lung; Male; Nitric Oxide; Respiratory System; Sputum; Tandem Mass Spectrometry | 2011 |
Carotid restenosis is associated with plasma ADMA concentrations in carotid endarterectomy patients.
Topics: Aged; Arginine; Carotid Artery Diseases; Cohort Studies; Cysteine; Endarterectomy, Carotid; Female; Homocysteine; Humans; Male; Middle Aged; Regression Analysis | 2011 |
Asymmetric dimethylarginine (ADMA) levels are increased in patients with fibromyalgia: correlation with tumor necrosis factor-α (TNF-α) and 8-iso-prostaglandin F(2α) (8-iso-PGF(2α)).
Topics: Adult; Arginine; Dinoprost; Female; Fibromyalgia; Humans; Male; Middle Aged; Surveys and Questionnaires; Tumor Necrosis Factor-alpha | 2011 |
Acute effects of hyperglycaemia on asymmetric dimethylarginine (ADMA), adiponectin and inflammatory markers (IL-6, hs-CRP) in overweight and obese women with metabolic syndrome.
Topics: Adiponectin; Adult; Aged; Arginine; Biomarkers; Female; Humans; Hyperglycemia; Interleukin-6; Metabolic Syndrome; Middle Aged; Obesity; Young Adult | 2010 |
Asymmetric dimethylarginine in young people with Type 1 diabetes: a paradoxical association with HbA(1c).
Topics: Adolescent; Albuminuria; Arginine; Biomarkers; Blood Glucose; Cardiovascular Diseases; Child; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Female; Glycated Hemoglobin; Humans; Longitudinal Studies; Male; Risk Factors | 2011 |
Effects of asymmetric dimethylarginine on bovine retinal capillary endothelial cell proliferation, reactive oxygen species production, permeability, intercellular adhesion molecule-1, and occludin expression.
Topics: Animals; Antioxidants; Arginine; Blotting, Western; Cattle; Cell Proliferation; Endothelial Cells; Enzyme Inhibitors; Intercellular Adhesion Molecule-1; Membrane Proteins; Occludin; Permeability; Reactive Oxygen Species; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; Tight Junctions | 2011 |
The L-arginine-asymmetric dimethylarginine ratio is strongly related to the severity of chronic heart failure. No effects of exercise training.
Topics: Aged; Aged, 80 and over; Arginine; Endothelium, Vascular; Exercise Therapy; Exercise Tolerance; Female; Flow Cytometry; Health Status Indicators; Heart Failure; Humans; Leukocytes; Male; Middle Aged; Natriuretic Peptide, Brain; Nitric Oxide Synthase; Peptide Fragments; Reactive Oxygen Species; Severity of Illness Index; Stroke Volume; Treatment Outcome; Ventricular Function, Left | 2011 |
The association of dimethylarginine dimethylaminohydrolase 1 gene polymorphism with type 2 diabetes: a cohort study.
Topics: Aged; Amidohydrolases; Analysis of Variance; Arginine; Biomarkers; Blood Glucose; Cardiovascular Diseases; Case-Control Studies; Chi-Square Distribution; Chromatography, High Pressure Liquid; Cohort Studies; Coronary Angiography; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; Humans; Insulin; Insulin Resistance; Kaplan-Meier Estimate; Linear Models; Linkage Disequilibrium; Logistic Models; Male; Middle Aged; Odds Ratio; Phenotype; Polymorphism, Genetic; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Taiwan | 2011 |
Simultaneous gas chromatography-tandem mass spectrometry quantification of symmetric and asymmetric dimethylarginine in human urine.
Topics: Adult; Arginine; Gas Chromatography-Mass Spectrometry; Humans; Stereoisomerism; Tandem Mass Spectrometry | 2011 |
Regional differences in hypertensive cardiovascular remodeling between fishing and farming communities in Japan.
Topics: Aged; Agriculture; Arginine; Carotid Arteries; Cross-Sectional Studies; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Female; Fisheries; Heart Ventricles; Humans; Hypertension; Japan; Male; Middle Aged; Ultrasonography | 2011 |
Inflammation and reduced endothelial function in the course of severe acute heart failure.
Topics: Acute Disease; Aged; Aged, 80 and over; Arginine; Biomarkers; Case-Control Studies; Endothelium, Vascular; Female; Heart Failure; Humans; Inflammation; Inflammation Mediators; Intercellular Adhesion Molecule-1; Interleukin-6; Interleukin-8; Male; Middle Aged; Prospective Studies; Shock, Cardiogenic; Vascular Cell Adhesion Molecule-1; Vasodilation | 2011 |
Serum asymmetric dimethylarginine levels in diabetic patients with neuropathy.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Diabetic Neuropathies; Electrophysiology; Female; Humans; Male; Middle Aged | 2011 |
NO problem: arterial and venous endothelial function and erectile dysfunction.
Topics: Arginine; Arteries; Biomarkers; Blood Flow Velocity; Cardiovascular Diseases; Endothelium, Vascular; Humans; Impotence, Vasculogenic; Male; Nitric Oxide; Penile Erection; Penis; Predictive Value of Tests; Regional Blood Flow; Risk Assessment; Risk Factors; Severity of Illness Index; Ultrasonography, Doppler, Color; Up-Regulation; Veins | 2011 |
Asymmetric dimethylarginine and vascular indices of atherosclerosis in patients after coarctation of aorta repair.
Topics: Adult; Aortic Coarctation; Arginine; Atherosclerosis; Biomarkers; Blood Flow Velocity; C-Reactive Protein; Cardiac Surgical Procedures; Carotid Intima-Media Thickness; Female; Humans; Male; Nitrates; Nitrites; Postoperative Complications; Pulsatile Flow; Vascular Stiffness; Vasodilation | 2012 |
Relationship of asymmetric dimethylarginine with penile Doppler ultrasound parameters in men with vasculogenic erectile dysfunction.
Topics: Adult; Aged; Analysis of Variance; Arginine; Arteries; Biomarkers; Blood Flow Velocity; Cardiovascular Diseases; Case-Control Studies; Greece; Humans; Impotence, Vasculogenic; Male; Middle Aged; Penile Erection; Penis; Predictive Value of Tests; Regional Blood Flow; Regression Analysis; Retrospective Studies; Risk Assessment; Risk Factors; ROC Curve; Severity of Illness Index; Ultrasonography, Doppler, Color; Up-Regulation; Veins | 2011 |
[The correlation of asymmetrical dimethylarginine level and oxidative stress to the onset of Alzheimer's disease].
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Arginine; Female; Humans; Male; Malondialdehyde; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Peptide Fragments; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2010 |
Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine.
Topics: Adolescent; Adult; Arginine; Biomarkers; Cerebral Arteries; Endothelial Cells; Female; Humans; Male; Middle Aged; Migraine Disorders; Nitric Oxide; Oxidative Stress; Up-Regulation; Young Adult | 2011 |
High concentrations of asymmetric dimethylarginine are associated with ST-segment resolution failure after reperfusion for acute myocardial infarction.
Topics: Angioplasty; Arginine; Biomarkers; Blood Circulation; Electrocardiography; Female; Humans; Lipid Metabolism; Male; Microvessels; Middle Aged; Myocardial Infarction; Reperfusion; Risk Factors | 2011 |
Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsis.
Topics: Adult; Aged; Arginine; Biological Availability; Case-Control Studies; Endothelium, Vascular; Female; Humans; Longitudinal Studies; Male; Middle Aged; Multiple Organ Failure; Nitric Oxide; Sepsis; Severity of Illness Index | 2011 |
Blood pressure and not uraemia is the major determinant of arterial stiffness and endothelial dysfunction in patients with chronic kidney disease and minimal co-morbidity.
Topics: Adult; Analysis of Variance; Arginine; Biomarkers; Blood Pressure; Brachial Artery; C-Reactive Protein; Carotid Arteries; Case-Control Studies; Chronic Disease; Comorbidity; Compliance; Cross-Sectional Studies; Disease Progression; Endothelin-1; Endothelium, Vascular; Female; Femoral Artery; Glomerular Filtration Rate; Humans; Isoprostanes; Kidney; Kidney Diseases; Linear Models; Male; Middle Aged; Peripheral Arterial Disease; Prospective Studies; Pulsatile Flow; Risk Assessment; Risk Factors; Scotland; Uremia; Vasodilation | 2011 |
cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amidohydrolases; Apoptosis; Arginine; Cell Proliferation; Cell Survival; Cells, Cultured; Cyclic GMP; Cytokines; Endothelial Cells; Hemodynamics; Humans; Hypertension, Pulmonary; Naphthyridines; Nitric Oxide; Phosphodiesterase Inhibitors; Promoter Regions, Genetic; Pulmonary Gas Exchange | 2011 |
Targeting dimethylarginine dimethylaminohydrolases in pulmonary arterial hypertension: a new approach to improve vascular dysfunction?
Topics: Amidohydrolases; Arginine; Humans; Hypertension, Pulmonary; Naphthyridines; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase Inhibitors | 2011 |
Effects of coronary revascularization with or without cardiopulmonary bypass on plasma levels of asymmetric dimethylarginine.
Topics: Aged; Arginine; Biomarkers; Cardiopulmonary Bypass; Chromatography, High Pressure Liquid; Coronary Artery Bypass; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Reperfusion Injury; Tandem Mass Spectrometry | 2011 |
Relationships between serum levels of thyroid hormones and serum concentrations of asymmetric dimethylarginine (ADMA) and N-terminal-pro-B-type natriuretic peptide (NT-proBNP) in patients with Graves' disease.
Topics: Adult; Arginine; Biomarkers; Blood Pressure; Cardiovascular Diseases; Cross-Sectional Studies; Endothelium, Vascular; Female; Graves Disease; Heart Rate; Hospitals, University; Humans; Immunoglobulins, Thyroid-Stimulating; Male; Natriuretic Peptide, Brain; Peptide Fragments; Risk Factors; Thyroid Hormones; Thyroxine; Triiodothyronine | 2011 |
Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity.
Topics: Adult; Arginine; Athletes; Cardiovascular Diseases; Enzyme-Linked Immunosorbent Assay; Exercise; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Nitric Oxide; Obesity; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; Surveys and Questionnaires | 2011 |
Arginine/asymmetric dimethylarginine ratio and cardiovascular risk factors in patients with predialytic chronic kidney disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Cardiovascular Diseases; Female; Glomerular Filtration Rate; Humans; Kidney Failure, Chronic; Male; Middle Aged; Risk Factors; Young Adult | 2011 |
Elevated concentration of asymmetric dimethylarginine (ADMA) in individuals with metabolic syndrome.
Topics: Arginine; Body Mass Index; Case-Control Studies; Chile; Cholesterol, LDL; Female; Humans; Insulin Resistance; Lipid Peroxidation; Male; Malondialdehyde; Metabolic Syndrome; Middle Aged; Nitric Oxide Synthase; Oxidative Stress; Plasminogen Activator Inhibitor 1; Vascular Cell Adhesion Molecule-1; Waist Circumference | 2011 |
Could ADMA levels in young adults born preterm predict an early endothelial dysfunction?
Topics: Adolescent; Adult; Arginine; Early Diagnosis; Endothelium, Vascular; Female; Gestational Age; Humans; Infant, Extremely Low Birth Weight; Infant, Low Birth Weight; Infant, Newborn; Male; Predictive Value of Tests; Premature Birth; Vascular Diseases; Young Adult | 2012 |
Increased plasma level of asymmetric dimethylarginine in hypertensive rats facilitates platelet aggregation: role of plasma tissue factor.
Topics: Animals; Arginine; Hypertension; Male; Platelet Aggregation; Random Allocation; Rats; Rats, Inbred WKY; Thromboplastin; Up-Regulation | 2011 |
Asymmetric dimethylarginine impairs fibrinolytic activity in human umbilical vein endothelial cells via p38 MAPK and NF-κB pathways.
Topics: Arginine; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; MAP Kinase Signaling System; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Plasminogen Activator Inhibitor 1; RNA, Messenger; Signal Transduction; Tissue Plasminogen Activator; Umbilical Veins | 2011 |
Asymmetric dimethylarginine levels in Buerger's disease.
Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Chi-Square Distribution; Female; Humans; Male; Middle Aged; Peripheral Arterial Disease; Predictive Value of Tests; Prognosis; Risk Assessment; Risk Factors; Severity of Illness Index; Smoking; Thromboangiitis Obliterans; Turkey; Up-Regulation; Young Adult | 2011 |
Contribution of endogenous inhibitor of nitric oxide synthase to hepatic mitochondrial dysfunction in streptozotocin-induced diabetic rats.
Topics: Adenosine Triphosphate; Animals; Arginine; Cell Line, Tumor; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Hepatocytes; Ion Channels; Liver; Male; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria, Liver; Mitochondrial Proteins; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Superoxide Dismutase; Transcription Factors; Uncoupling Protein 2 | 2011 |
The levels of nitric oxide and asymmetric dimethylarginine in the rat endometriosis model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Disease Models, Animal; Endometriosis; Female; Nitric Oxide; Peritoneal Diseases; Random Allocation; Rats; Rats, Sprague-Dawley | 2011 |
Methionine-induced homocysteinemia impairs endothelial function in hypertensives: the role of asymmetrical dimethylarginine and antioxidant vitamins.
Topics: Adult; Antioxidants; Arginine; Ascorbic Acid; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Male; Methionine; Middle Aged; Vasodilation; Vitamin E | 2011 |
Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.
Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Cardiovascular Diseases; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Female; Genotype; Hypertension; Infusion Pumps, Implantable; Male; Mice; Mice, 129 Strain; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phenotype; Risk Factors; RNA Interference; Substrate Specificity; Time Factors; Transfection | 2011 |
Asymmetric dimethylarginine level in hyperglycemic gestation.
Topics: Adult; Arginine; Blood Glucose; Body Mass Index; Case-Control Studies; Chromatography, High Pressure Liquid; Diabetes, Gestational; Early Diagnosis; Female; Glucose Intolerance; Glucose Tolerance Test; Humans; Hyperglycemia; Insulin; Insulin Resistance; Pregnancy; Pregnancy Trimester, Third; Prospective Studies; Reproducibility of Results; Spectrometry, Fluorescence | 2011 |
Lipid-apheresis improves microcirculation of the upper limbs.
Topics: Adult; Aged; Arginine; Atrial Natriuretic Factor; Blood Component Removal; Blood Flow Velocity; Endothelin-1; Epinephrine; Erythrocyte Aggregation; Female; Fibrinogen; Hand; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Laser-Doppler Flowmetry; Lipids; Male; Microcirculation; Microscopic Angioscopy; Middle Aged; Norepinephrine; Photoplethysmography | 2011 |
Protective effect of neferine on endothelial cell nitric oxide production induced by lysophosphatidylcholine: the role of the DDAH-ADMA pathway.
Topics: Aldehydes; Amidohydrolases; Antioxidants; Arginine; Benzylisoquinolines; Cells, Cultured; Endothelial Cells; Humans; Lysophosphatidylcholines; Nitric Oxide; Reactive Oxygen Species; Umbilical Veins | 2011 |
[Alterations in reactive oxygen species and dimethylarginine dimethylaminohydrolase-asymmetric dimethyl-arginine system in the process of endothelial cell senescence induced by high glucose].
Topics: Amidohydrolases; Arginine; Cells, Cultured; Cellular Senescence; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Nitric Oxide Synthase; Oxidative Stress; Reactive Oxygen Species | 2011 |
Asymmetric dimethylarginine and coronary artery calcium scores are increased in patients infected with human immunodeficiency virus.
Topics: Adult; Arginine; Biomarkers; Calcinosis; California; Case-Control Studies; Chi-Square Distribution; Coronary Angiography; Coronary Artery Disease; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Risk Assessment; Risk Factors; RNA, Viral; Tomography, X-Ray Computed; Up-Regulation | 2011 |
Left ventricular hypertrophy is associated with inflammation in sodium loaded subtotal nephrectomized rats.
Topics: Animals; Arginine; Creatinine; Disease Models, Animal; Fibrosis; Hypertension; Hypertrophy, Left Ventricular; Inflammation; Interleukin-6; Kidney Failure, Chronic; Male; Nephrectomy; Parathyroid Hormone; Phosphates; Rats; Rats, Wistar; Risk Factors; Sclerosis; Sodium Chloride | 2011 |
Serum asymmetric dimethylarginine and nitric oxide levels in obese postmenopausal women.
Topics: Adiponectin; Aged; Aged, 80 and over; Anthropometry; Arginine; Body Mass Index; Female; Ghrelin; Humans; Leptin; Middle Aged; Nitrates; Nitric Oxide; Obesity; Postmenopause | 2011 |
In patients with aortic stenosis increased flow-mediated dilation is independently associated with higher peak jet velocity and lower asymmetric dimethylarginine levels.
Topics: Aged; Aortic Valve Stenosis; Arginine; Blood Flow Velocity; Blood Pressure; Brachial Artery; Dilatation, Pathologic; Echocardiography; Endothelium, Vascular; Female; Humans; Male; Nitric Oxide Synthase; Risk Factors; Severity of Illness Index; Stroke Volume; Ultrasonography, Doppler | 2011 |
Active site mutant dimethylarginine dimethylaminohydrolase 1 expression confers an intermediate tumour phenotype in C6 gliomas.
Topics: Amidohydrolases; Animals; Arginine; Catalytic Domain; Female; Glioma; Magnetic Resonance Imaging; Mice; Mice, Nude; Microscopy, Fluorescence; Mutation; Neoplasm Transplantation; Neovascularization, Pathologic; Phenotype; Rats; Transplantation, Heterologous; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2011 |
Asymmetric dimethylarginine concentration and recurrence of atrial tachyarrythmias after catheter ablation in patients with persistent atrial fibrillation.
Topics: Arginine; Atrial Fibrillation; Biomarkers; Body Surface Potential Mapping; Catheter Ablation; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Recurrence; Risk Assessment; Survival Rate; Time Factors; Treatment Outcome | 2011 |
Chronic kidney disease: the silent enemy?
Topics: Anesthesiology; Arginine; Creatinine; Glomerular Filtration Rate; Humans; Kidney; Kidney Failure, Chronic; Kidney Transplantation; Renal Dialysis; Risk; Treatment Outcome | 2011 |
Cellular hypomethylation is associated with impaired nitric oxide production by cultured human endothelial cells.
Topics: Arginine; Cells, Cultured; Endothelial Cells; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Hyperhomocysteinemia; Methylation; Nitric Oxide; Nitric Oxide Synthase Type III; S-Adenosylhomocysteine; Vascular Diseases | 2012 |
Vascular function in the diagnostic categories of polycystic ovary syndrome.
Topics: Adult; Arginine; C-Reactive Protein; Cardiovascular Diseases; Cross-Sectional Studies; Endothelium, Vascular; Female; Humans; Insulin Resistance; Overweight; Phenotype; Plasminogen Activator Inhibitor 1; Polycystic Ovary Syndrome; Vascular Resistance | 2011 |
The effect of pharmacological treatment on ADMA in patients with heart failure.
Topics: Aged; Arginine; Female; Heart Failure; Humans; Male; Middle Aged | 2011 |
Coronary flow reserve and asymmetric dimethylarginine levels: new measurements for identifying subclinical atherosclerosis in patients with psoriatic arthritis.
Topics: Adult; Aged; Arginine; Arthritis, Psoriatic; Atherosclerosis; Biomarkers; Carotid Artery, Common; Coronary Circulation; Dipyridamole; Echocardiography, Stress; Enzyme Inhibitors; Female; Humans; Middle Aged; Tunica Intima; Tunica Media | 2011 |
Relationship between plasma coenzyme Q10, asymmetric dimethylarginine and arterial stiffness in patients with phenotypic or genotypic familial hypercholesterolemia on long-term statin therapy.
Topics: Aged; Arginine; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Genotype; Heterozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Male; Middle Aged; Mutation; Receptors, LDL; Ubiquinone; Vascular Stiffness | 2011 |
Asymmetric dimethylarginine and clinical outcomes in chronic kidney disease.
Topics: Aged; Aged, 80 and over; Albuminuria; Arginine; Biomarkers; Chi-Square Distribution; Chromatography, High Pressure Liquid; Disease-Free Survival; Female; Glomerular Filtration Rate; Humans; Kaplan-Meier Estimate; Kidney Diseases; Male; Middle Aged; Myocardial Infarction; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Stroke; Taiwan; Time Factors | 2011 |
Inflammation and asymmetric dimethylarginine for predicting death and cardiovascular events in ESRD patients.
Topics: Adult; Aged; Analysis of Variance; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Chi-Square Distribution; Cohort Studies; Female; Humans; Inflammation; Inflammation Mediators; Interleukin-6; Italy; Kidney Failure, Chronic; Male; Middle Aged; Prognosis; Proportional Hazards Models; Renal Dialysis; Risk Assessment; Risk Factors; Time Factors | 2011 |
The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis.
Topics: Amidohydrolases; Animals; Antibiotics, Antineoplastic; Apoptosis; Arginine; Bleomycin; Cell Line; Cell Proliferation; Collagen; Female; Fibroblasts; Fibrosis; Humans; Idiopathic Pulmonary Fibrosis; Isoenzymes; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Nitric Oxide Synthase Type II; Random Allocation | 2011 |
DDAH says NO to ADMA.
Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Endothelial Cells; Humans; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Risk Factors; Substrate Specificity | 2011 |
Vascular endothelial function assessed by a noninvasive ultrasound method and serum asymmetric dimethylarginine concentrations in mild-to-moderate plaque-type psoriatic patients.
Topics: Acute-Phase Proteins; Adult; Arginine; C-Reactive Protein; Case-Control Studies; Endothelium, Vascular; Female; Fibrinogen; Humans; Male; Psoriasis; Severity of Illness Index; Ultrasonography; Vasodilation | 2011 |
Serum levels of arginase I are associated with left ventricular function after myocardial infarction.
Topics: Arginase; Arginine; Case-Control Studies; Humans; Myocardial Infarction; Stroke Volume; Ventricular Function, Left | 2011 |
Chronic renal failure alters endothelial function in cerebral circulation in mice.
Topics: Analysis of Variance; Animals; Apolipoproteins E; Arginine; Arterioles; Blotting, Western; Caveolin 1; Cerebrovascular Circulation; Cerebrovascular Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Inflammation Mediators; Kidney Failure, Chronic; Mice; Mice, Inbred C57BL; Mice, Knockout; Nephrectomy; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Pia Mater; PPAR gamma; rho-Associated Kinases; Vascular Cell Adhesion Molecule-1; Vasodilation; Vasodilator Agents | 2011 |
Quantitation of L-arginine and asymmetric dimethylarginine in human plasma by LC-selective ion mode-MS for Type 2 diabetes mellitus study.
Topics: Adult; Aged; Arginine; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Female; Humans; Male; Mass Spectrometry; Middle Aged | 2011 |
Age-related modification of antioxidant enzyme activities in relation to cardiovascular risk factors.
Topics: Aged; Aged, 80 and over; Aging; Apolipoproteins A; Arginine; Cardiovascular Diseases; Catalase; Enzyme-Linked Immunosorbent Assay; Female; Fetuins; Glutathione Peroxidase; Humans; Lipid Peroxidation; Lipoproteins; Lipoproteins, LDL; Male; Oxidation-Reduction; Oxidative Stress; Risk Factors; Statistics as Topic; Superoxide Dismutase | 2012 |
The biological effect of pharmacological treatment on dimethylaminohydrolases (DDAH-1) and cationic amino acid transporter-1 (CAT-1) expression in patients with acute congestive heart failure.
Topics: Acute Disease; Aged; Amidohydrolases; Arginine; Cardiovascular Agents; Cationic Amino Acid Transporter 1; Chromatography, High Pressure Liquid; Echocardiography, Doppler; Female; Heart Failure; Humans; Italy; Male; Middle Aged; Stroke Volume; Treatment Outcome; Ventricular Function, Left | 2011 |
Elevated plasma asymmetric dimethylarginine level in acute myocardial infarction patients as a predictor of poor prognosis and angiographic impaired reperfusion.
Topics: Aged; Arginine; Coronary Angiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Prognosis | 2011 |
Asymmetric dimethylarginine (ADMA) levels display a morning peak in patients with acute myocardial infarction.
Topics: Aged; Arginine; Biomarkers; Blood Pressure; Body Mass Index; Circadian Rhythm; Cross-Sectional Studies; Female; Humans; Linear Models; Male; Middle Aged; Myocardial Infarction; Nitric Oxide Synthase; Nitrogen Oxides; Platelet Activation; Time Factors | 2011 |
Endogenous hydrogen sulfide is involved in asymmetric dimethylarginine-induced protection against neurotoxicity of 1-methyl-4-phenyl-pyridinium ion.
Topics: 1-Methyl-4-phenylpyridinium; Aminooxyacetic Acid; Animals; Antioxidants; Arginine; Cyclin D1; Cystathionine beta-Synthase; Cytochromes c; Down-Regulation; Hydrogen Sulfide; Membrane Potential, Mitochondrial; Neuroprotective Agents; PC12 Cells; Rats; Reactive Oxygen Species | 2011 |
Asymmetric dimethylarginine predicts appropriate implantable cardioverter-defibrillator intervention in patients with left ventricular dysfunction.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Defibrillators, Implantable; Follow-Up Studies; Humans; Male; Middle Aged; Nitric Oxide; Predictive Value of Tests; Prospective Studies; Retrospective Studies; Risk Factors; Tachycardia, Ventricular; Treatment Outcome; Ventricular Dysfunction, Left | 2011 |
Effect of silibinin on endothelial dysfunction and ADMA levels in obese diabetic mice.
Topics: Acetylcholine; Animals; Antioxidants; Aorta; Arginine; Diabetes Mellitus; Disease Models, Animal; Endothelium, Vascular; Insulin Resistance; Liver; Male; Mice; Mice, Obese; Nitroprusside; Obesity; Phenylephrine; Silybin; Silymarin; Vasoconstrictor Agents; Vasodilator Agents | 2011 |
Serum asymmetric dimethylarginine, nitrate, vitamin B(12), and homocysteine levels in individuals with pulmonary embolism.
Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Female; Homocysteine; Humans; Male; Middle Aged; Nitrates; Oxygen; Partial Pressure; Predictive Value of Tests; Prognosis; Pulmonary Embolism; Pulmonary Wedge Pressure; Risk Factors; Vitamin B 12 | 2011 |
Symmetric dimethylarginine is a marker of detrimental outcome in the acute phase after ischaemic stroke: role of renal function.
Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Brain Ischemia; Chromatography, Liquid; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Kidney; Male; Middle Aged; Multivariate Analysis; Outcome Assessment, Health Care; Prognosis; Proportional Hazards Models; Stroke; Tandem Mass Spectrometry; Time Factors | 2012 |
AADMA as a marker of endothelial dysfunction in prediabetic women.
Topics: Adult; Arginine; Biomarkers; Body Mass Index; Brachial Artery; Chromatography, High Pressure Liquid; Confidence Intervals; Cross-Sectional Studies; Endothelium, Vascular; Female; Glycated Hemoglobin; Humans; Linear Models; Middle Aged; Multivariate Analysis; Prediabetic State; Time Factors; Women's Health | 2011 |
Plasma asymmetric dimethylarginine predicts death and major adverse cardiovascular events in individuals referred for coronary angiography.
Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Cardiovascular Diseases; Coronary Angiography; Death; Female; Follow-Up Studies; Humans; Male; Middle Aged; Predictive Value of Tests; Referral and Consultation; Risk Factors | 2011 |
Symmetric dimethylarginine as a proinflammatory agent in chronic kidney disease.
Topics: Acetylcysteine; Aged; Aged, 80 and over; Arginine; Belgium; Biomarkers; Case-Control Studies; Cell Line; Chronic Disease; Cross-Sectional Studies; Female; Humans; Inflammation Mediators; Interleukin-6; Kidney Diseases; Linear Models; Male; Middle Aged; Monocytes; NF-kappa B; Predictive Value of Tests; ROC Curve; Tumor Necrosis Factor-alpha | 2011 |
Asymmetric dimethylarginine confers the communication between endothelial and smooth muscle cells and leads to VSMC migration through p38 and ERK1/2 signaling cascade.
Topics: Animals; Arginine; Blotting, Western; Cell Movement; Cells, Cultured; Endothelial Cells; Humans; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Rats; Signal Transduction | 2011 |
Simultaneous determination of L-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in the plasma of rodents with LC-MS/MS.
Topics: Animals; Arginine; Calibration; Chromatography, High Pressure Liquid; Indicators and Reagents; Male; Mass Spectrometry; Mice; Mice, Inbred ICR; Quality Control; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry | 2011 |
Homocysteine and asymmetric dimethylarginine in relation to B vitamins in elderly people.
Topics: Aged; Aged, 80 and over; Arginine; Biological Availability; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Hypercholesterolemia; Male; Nitric Oxide; Nitric Oxide Synthase; Statistics as Topic; Vasodilation; Vitamin B 12; Vitamin B 6 | 2011 |
Unilateral nephrectomy causes an abrupt increase in inflammatory mediators and a simultaneous decrease in plasma ADMA: a study in living kidney donors.
Topics: Arginine; C-Reactive Protein; Creatinine; Female; Humans; Inflammation Mediators; Interleukin-6; Kidney Function Tests; Living Donors; Longitudinal Studies; Male; Middle Aged; Nephrectomy; Prospective Studies; Tissue and Organ Harvesting; Urea | 2011 |
Plasma asymmetric dimethylarginine (ADMA) concentrations in patients with first and multiple episode schizophrenia.
Topics: Adult; Arginine; Chromatography, High Pressure Liquid; Humans; Male; Psychiatric Status Rating Scales; Schizophrenia; Statistics, Nonparametric; Young Adult | 2011 |
Day-night variations in endothelial dysfunction markers and haemostatic factors in sleep apnoea.
Topics: Adult; Arginine; Blood Coagulation; Body Mass Index; Cardiovascular Diseases; CD40 Ligand; Circadian Rhythm; Endothelium, Vascular; Erythrocyte Count; Factor VII; Humans; Leukocyte Count; Middle Aged; Plasminogen Activator Inhibitor 1; Platelet Count; Sleep Apnea Syndromes; von Willebrand Factor; Waist Circumference | 2012 |
Changes in the arginine methylation of organ proteins during the development of diabetes mellitus.
Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Diabetes Mellitus; Male; Methylation; Mice; Nitric Oxide; Nitric Oxide Synthase | 2011 |
Role of asymmetric dimethylarginine in acute lung injury induced by cerebral ischemia/reperfusion injury in rats.
Topics: Acute Lung Injury; Animals; Arginine; Brain Ischemia; Male; Myosin-Light-Chain Kinase; Nitric Oxide Synthase; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Up-Regulation | 2011 |
Actin cytoskeleton modulates ADMA-induced NF-kappaB nuclear translocation and ICAM-1 expression in endothelial cells.
Topics: Actin Cytoskeleton; Arginine; Cell Nucleus; Cytochalasin D; Depsipeptides; DNA; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; NF-kappa B; Protein Binding; Protein Transport; Stress Fibers; Transcription Factor RelA | 2011 |
Increased asymmetric dimethylarginine and enhanced inflammation are associated with impaired vascular reactivity in women with endometriosis.
Topics: Adult; Arginine; Biomarkers; Brachial Artery; C-Reactive Protein; Case-Control Studies; Endometriosis; Female; Humans; Inflammation Mediators; Interleukin-6; Japan; Least-Squares Analysis; Lipids; Regression Analysis; Serum Amyloid A Protein; Ultrasonography, Doppler; Up-Regulation; Vasodilation | 2011 |
Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizing factor in small arteries from rat.
Topics: Animals; Anthracenes; Apamin; Arginine; Biological Factors; Drug Evaluation, Preclinical; Human Umbilical Vein Endothelial Cells; Indoles; Male; Mesenteric Arteries; Nitric Oxide; Nitric Oxide Synthase; Oximes; Potassium Channels, Calcium-Activated; Propane; Pyrazoles; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2011 |
Ascorbic acid or L-arginine improves cutaneous microvascular function in chronic kidney disease.
Topics: Adult; Arginine; Ascorbic Acid; Case-Control Studies; Female; Hot Temperature; Humans; Male; Microcirculation; Microdialysis; Middle Aged; Nitric Oxide; Oxidative Stress; Renal Insufficiency, Chronic; Skin; Vasodilation | 2011 |
The effect of calcineurin inhibitors on endothelial and platelet function in renal transplant patients.
Topics: Adult; Arginine; Calcineurin Inhibitors; Cyclosporine; Endothelium, Vascular; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Mycophenolic Acid; Nitric Oxide Synthase; P-Selectin; Platelet Activation; Platelet Aggregation; Tacrolimus | 2011 |
Determination of asymmetric dimethyl arginine in human serum by liquid chromatography-tandem mass spectrometry: clinical application in hypertensive subjects.
Topics: Adolescent; Adult; Arginine; Chromatography, High Pressure Liquid; Female; Humans; Hydrophobic and Hydrophilic Interactions; Hypertension; Male; Middle Aged; Tandem Mass Spectrometry; Young Adult | 2011 |
Late effects of renal transplantation on endothelial functions and cardiac morphology.
Topics: Adult; Arginine; C-Reactive Protein; Case-Control Studies; Cyclosporine; Endothelium, Vascular; Female; Heart; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Tacrolimus; Tunica Intima | 2011 |
Synergistic adverse prognostic effects of asymmetric dimethylarginine and endothelial progenitor-related cells deficiency after elective coronary angioplasty.
Topics: Aged; Angioplasty, Balloon, Coronary; Arginine; Cell Count; Elective Surgical Procedures; Endothelial Cells; Follow-Up Studies; Humans; Male; Middle Aged; Prognosis; Prospective Studies; Risk Factors; Stem Cells | 2011 |
Pseudomonas aeruginosa is associated with increased lung cytokines and asymmetric dimethylarginine compared with methicillin-resistant Staphylococcus aureus.
Topics: Animals; Arginine; Cytokines; Female; Interleukin-1; Interleukin-13; Lung; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred C57BL; Pseudomonas aeruginosa; Sheep | 2011 |
Asymmetric dimethylarginine (ADMA): is really a biomarker for cardiovascular prognosis?
Topics: Arginine; Cardiovascular Diseases; Coronary Angiography; Female; Humans; Male; Referral and Consultation | 2011 |
Sympathetic nerve traffic and asymmetric dimethylarginine in chronic kidney disease.
Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Chronic Disease; Cross-Sectional Studies; Disease Progression; Female; Glomerular Filtration Rate; Humans; Hypertrophy, Left Ventricular; Italy; Kidney; Kidney Diseases; Linear Models; Male; Proteinuria; Risk Assessment; Risk Factors; Severity of Illness Index; Sympathetic Fibers, Postganglionic; Ventricular Remodeling | 2011 |
Levels of soluble advanced glycation end product-receptors and other soluble serum markers as indicators of diabetic neuropathy in the foot.
Topics: Aged; Arginine; Biomarkers; Diabetes Mellitus, Type 2; Diabetic Foot; Diabetic Neuropathies; Glycated Hemoglobin; Humans; Male; Middle Aged; Nitric Oxide; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Solubility | 2011 |
Detection and quantification of α-keto-δ-(N(G),N(G)-dimethylguanidino)valeric acid: a metabolite of asymmetric dimethylarginine.
Topics: Adult; Arginine; Biochemistry; Calibration; Chromatography, High Pressure Liquid; Female; Guanidines; Humans; Keto Acids; Limit of Detection; Male; Mass Spectrometry; Middle Aged | 2011 |
Aliskiren prevents hypertension and reduces asymmetric dimethylarginine in young spontaneously hypertensive rats.
Topics: Amides; Animals; Antihypertensive Agents; Arginine; Blood Pressure; Dose-Response Relationship, Drug; Fumarates; Gene Expression Regulation, Enzymologic; Hypertension; Kidney Cortex; Male; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Renin | 2011 |
Exercise blood pressure response is related to asymmetric dimethylarginine and osteoprotegerin in hypertension.
Topics: Adult; Arginine; Biomarkers; Blood Pressure; Exercise; Exercise Test; Humans; Hypertension; Male; Middle Aged; Osteoprotegerin | 2011 |
The transhepatic endotoxin gradient is present despite liver cirrhosis and is attenuated after transjugular portosystemic shunt (TIPS).
Topics: Acute-Phase Proteins; Adult; Aged; Arginine; Bacterial Translocation; Carrier Proteins; Cohort Studies; Female; Gram-Negative Bacteria; Humans; Lipopolysaccharides; Liver Circulation; Liver Cirrhosis; Male; Membrane Glycoproteins; Middle Aged; Portasystemic Shunt, Transjugular Intrahepatic | 2011 |
A dietary approach to increase in-stent stenosis and face validity of a rat model for arterial angioplasty and stenting.
Topics: Angioplasty, Balloon; Animals; Arginine; Biomarkers; Carotid Arteries; Carotid Artery Injuries; Carotid Stenosis; Choline Deficiency; Diet, Atherogenic; Disease Models, Animal; Endothelial Cells; Female; Hyperplasia; Inflammation Mediators; Interleukin-6; Lipids; Male; Platelet Activation; Rats; Rats, Sprague-Dawley; Recurrence; Reproducibility of Results; Stents; Thromboxane B2; Time Factors; Ultrasonography, Doppler, Color | 2011 |
Role of dimethylarginine dimethylaminohydrolase activity in regulation of tissue and plasma concentrations of asymmetric dimethylarginine in an animal model of prolonged critical illness.
Topics: Amidohydrolases; Animals; Arginine; Critical Illness; Kidney; Liver; Male; Multivariate Analysis; Muscle, Skeletal; Myocardium; Rabbits; Regression Analysis | 2012 |
Apelin-13 passes through the ADMA-damaged endothelial barrier and acts on vascular smooth muscle cells.
Topics: Acetophenones; Arginine; Blotting, Western; Capillary Permeability; Cells, Cultured; Coculture Techniques; Dextrans; Fluorescein-5-isothiocyanate; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Intercellular Junctions; Intercellular Signaling Peptides and Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin Light Chains; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Stress Fibers; Time Factors | 2011 |
Levels of asymmetric dimethylarginine throughout normal pregnancy and in pregnancies complicated with preeclampsia or had a small for gestational age baby.
Topics: Adult; Arginine; Blood Chemical Analysis; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Fetal Growth Retardation; Humans; Infant, Newborn; Infant, Small for Gestational Age; Male; Osmolar Concentration; Pre-Eclampsia; Pregnancy | 2012 |
Endothelial dysfunction and high cardiovascular risk profile in severe alcoholics improve only partially following a medium-term alcohol withdrawal.
Topics: Adult; Age of Onset; Aged; Alcoholism; Arginine; Biomarkers; Blood Pressure; Brachial Artery; Cardiovascular Diseases; Confidence Intervals; Endothelium, Vascular; Female; Heart Rate; Humans; Insulin Resistance; Lipids; Logistic Models; Male; Middle Aged; Odds Ratio; Oxidative Stress; Risk Assessment; Smoking; Vasodilation | 2012 |
Immunosuppressants accelerate microvascular thrombus formation in vivo: role of endothelial cell activation.
Topics: Animals; Arginine; Endothelium, Vascular; Immunohistochemistry; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Microvessels; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; P-Selectin; Reperfusion Injury; Thrombosis; Vascular Cell Adhesion Molecule-1 | 2012 |
Reference intervals for plasma L-arginine and the L-arginine:asymmetric dimethylarginine ratio in the Framingham Offspring Cohort.
Topics: Aged; Arginine; Chromatography, Liquid; Cross-Sectional Studies; Dietary Supplements; Endothelium-Dependent Relaxing Factors; Female; Glomerular Filtration Rate; Humans; Male; Massachusetts; Middle Aged; Nitric Oxide Synthase; Reference Values; Tandem Mass Spectrometry | 2011 |
Stimulus-specific blockade of nitric oxide-mediated dilatation by asymmetric dimethylarginine (ADMA) and monomethylarginine (L-NMMA) in rat aorta and carotid artery.
Topics: Animals; Aorta; Arginine; Carotid Arteries; Female; Male; Naphthyridines; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Phenylephrine; Pyrimidines; Rats; Rats, Wistar; Superoxide Dismutase; Vasodilation | 2011 |
The role of asymmetric dimethyl arginine and oxidant/antioxidant system in preeclampsia.
Topics: Adult; Antioxidants; Arginine; Case-Control Studies; Citrulline; Female; Fetal Blood; Humans; Lipid Peroxidation; Malondialdehyde; Oxidants; Oxidative Stress; Pre-Eclampsia; Pregnancy; Young Adult | 2011 |
Apocynin attenuates oxidative stress and hypertension in young spontaneously hypertensive rats independent of ADMA/NO pathway.
Topics: Acetophenones; Animals; Antioxidants; Arginine; Hypertension; Male; NADPH Oxidases; Nitric Oxide; Oxidative Stress; Random Allocation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species | 2012 |
Increased asymmetric dimethylarginine (ADMA) dimethylaminohydrolase (DDAH) activity in childhood hypercholesterolemia type II.
Topics: Adolescent; Amidohydrolases; Arginine; Case-Control Studies; Child; Female; Humans; Hypercholesterolemia; Male; Statistics, Nonparametric | 2012 |
Favorable effect of short-term lifestyle intervention on human paraoxonase-1 activity and adipokine levels in childhood obesity.
Topics: Adipokines; Adiponectin; Adolescent; Arginine; Aryldialkylphosphatase; Body Mass Index; Child; Diet; E-Selectin; Feeding Behavior; Female; Humans; Leptin; Life Style; Lipids; Male; Motor Activity; Obesity; Risk Factors | 2011 |
Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase.
Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Dose-Response Relationship, Drug; Female; HL-60 Cells; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Models, Animal; Neutrophils; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxidase; Signal Transduction; Superoxides | 2011 |
Asymmetric dimethylarginine (ADMA) determines the improvement of hepatic endothelial dysfunction by vitamin E in cirrhotic rats.
Topics: Animals; Antioxidants; Arginine; Drug Synergism; Endothelial Cells; Enzyme Inhibitors; Hemodynamics; Hypertension, Portal; In Vitro Techniques; Lipid Peroxidation; Liver; Liver Cirrhosis, Experimental; Male; Nitric Oxide; Oxidative Stress; Perfusion; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vitamin E | 2012 |
Ethnicity-specific differences in L-arginine status in South African men.
Topics: Adult; Aged; Arginine; Black People; Cardiovascular Diseases; Cross-Sectional Studies; Humans; Hypertension; Linear Models; Male; Middle Aged; Multivariate Analysis; Prevalence; Risk Factors; South Africa; White People | 2012 |
Imbalance of arginine and asymmetric dimethylarginine is associated with markers of circulatory failure, organ failure and mortality in shock patients.
Topics: Aged; Area Under Curve; Arginine; Biomarkers; Blood Coagulation; Blood Glucose; Carbonates; Creatine Kinase; Female; Humans; Hydrogen-Ion Concentration; Lactic Acid; Male; Middle Aged; Multiple Organ Failure; Nitric Oxide; Nitric Oxide Synthase; Predictive Value of Tests; Prospective Studies; Severity of Illness Index; Shock | 2012 |
Continuous exposure to L-arginine induces oxidative stress and physiological tolerance in cultured human endothelial cells.
Topics: Arginase; Arginine; Ascorbic Acid; Cells, Cultured; Citrulline; Culture Media; Down-Regulation; Drug Tolerance; Free Radical Scavengers; Gene Expression; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Polyethylene Glycols; Superoxide Dismutase; Superoxides | 2012 |
Asymmetric dimethylarginine may mediate increased heat pain threshold in experimental chronic kidney disease.
Topics: Animals; Arginine; Enzyme Inhibitors; Hot Temperature; Kidney Failure, Chronic; Male; Nephrectomy; Nitric Oxide Synthase; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley | 2012 |
Endothelial dysfunction of the peripheral vascular bed in the acute phase after ischemic stroke.
Topics: Aged; Analysis of Variance; Arginine; Biomarkers; Blood Pressure; Case-Control Studies; Endothelium, Vascular; Female; Fingers; Forearm; Germany; Heart Failure; Humans; Hyperemia; Infarction, Middle Cerebral Artery; Linear Models; Male; Middle Aged; Plethysmography; Severity of Illness Index; Time Factors; Up-Regulation; Vasodilation | 2012 |
Relationships of osteoprotegerin with albuminuria and asymmetric dimethylarginine in essential hypertension: integrating vascular dysfunction.
Topics: Adult; Albuminuria; Arginine; Blood Pressure; Cross-Sectional Studies; Echocardiography; Endothelium, Vascular; Female; Humans; Hypertension; Male; Middle Aged; Osteoprotegerin | 2011 |
In vivo nitric oxide synthesis, insulin sensitivity, and asymmetric dimethylarginine in obese subjects without and with metabolic syndrome.
Topics: Adult; Arginine; Blood Glucose; Blood Pressure; Cholesterol, HDL; Female; Glucose Tolerance Test; Humans; Insulin Resistance; Male; Metabolic Syndrome; Nitrates; Nitric Oxide; Obesity; Saliva; Triglycerides; Waist Circumference | 2012 |
Asymmetric dimethylarginine, arginine and homoarginine at 11-13 weeks' gestation and preeclampsia: a case-control study.
Topics: Adult; Arginine; Case-Control Studies; Female; Gas Chromatography-Mass Spectrometry; Homoarginine; Humans; Nitric Oxide; Pre-Eclampsia; Pregnancy; Regression Analysis | 2013 |
Arginine and asymmetric dimethylarginine in puromycin aminonucleoside-induced chronic kidney disease in the rat.
Topics: Animals; Aorta; Arginase; Arginine; Creatinine; Dose-Response Relationship, Drug; Kidney Cortex; Kidney Failure, Chronic; Male; Oxidative Stress; Puromycin Aminonucleoside; Rats; Rats, Sprague-Dawley | 2012 |
Elevated asymmetric dimethylarginine in plasma: an early marker for endothelial dysfunction in non-alcoholic fatty liver disease?
Topics: Adult; Arginine; Biomarkers; Carotid Artery Diseases; Carotid Intima-Media Thickness; Fatty Liver; Humans; Male; Non-alcoholic Fatty Liver Disease; Young Adult | 2012 |
Endotoxemia exacerbates kidney injury and increases asymmetric dimethylarginine in young bile duct-ligated rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acute Kidney Injury; Animals; Arginine; Bile Ducts; Blotting, Western; Chromatography, High Pressure Liquid; Citrulline; Deoxyguanosine; Endotoxemia; Immunohistochemistry; Male; Rats; Rats, Sprague-Dawley | 2012 |
Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence.
Topics: Animals; Apoptosis; Arginine; Autophagy; Azoles; Cardiovascular Diseases; Cathepsins; Cell Membrane Permeability; Cells, Cultured; Cellular Senescence; Collagen Type I; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Hydrogen Peroxide; Isoindoles; Lysosomes; Mice; Mice, Knockout; Mice, Transgenic; Organoselenium Compounds; Recombinant Proteins; Risk Factors; Sirtuin 1; Stem Cells; Stress, Physiological | 2012 |
The combined ratios of L-arginine and asymmetric and symmetric dimethylarginine as biomarkers in spontaneously hypertensive rats.
Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Blood Pressure; Hypertension; Male; Models, Animal; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2012 |
Changes of skin temperature of parts of the body and serum asymmetric dimethylarginine (ADMA) in type-2 diabetes mellitus Indian patients.
Topics: Adult; Arginine; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; India; Infrared Rays; Male; Microcirculation; Middle Aged; Risk; Risk Assessment; Skin Temperature; Temperature; Thermography | 2011 |
Dimethylated L-arginine analogues versus autoantibodies in early rheumatoid arthritis.
Topics: Adult; Arginine; Arthritis, Rheumatoid; Autoantibodies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Peptides, Cyclic; Rheumatoid Factor | 2012 |
Nitric oxide activity in platelets of dengue haemorrhagic fever patients: the apparent paradoxical role of ADMA and l-NMMA.
Topics: Adult; Arginine; Blood Platelets; Brazil; Enzyme Inhibitors; Female; Humans; Male; Nitric Oxide Synthase; omega-N-Methylarginine; Platelet Aggregation; Severe Dengue; Thrombocytopenia | 2012 |
Inhibition of eNOS phosphorylation mediates endothelial dysfunction in renal failure: new effect of asymmetric dimethylarginine.
Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide Synthase Type III; Phosphorylation; Recombinant Proteins; Renal Insufficiency, Chronic; Vasodilation | 2012 |
The relationship between L-arginine/ADMA ratio and coronary collateral development in patients with low glomerular filtration rate.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Chi-Square Distribution; Collateral Circulation; Coronary Angiography; Coronary Circulation; Coronary Stenosis; Female; Glomerular Filtration Rate; Humans; Kidney Diseases; Linear Models; Logistic Models; Male; Middle Aged; Multivariate Analysis; Neovascularization, Physiologic; Odds Ratio; Risk Assessment; Risk Factors; Severity of Illness Index; Turkey | 2012 |
Development of an enzyme-linked immunosorbent assay system for the determination of asymmetric dimethylarginine using a specific monoclonal antibody.
Topics: Antibodies, Monoclonal; Arginine; Binding, Competitive; Enzyme-Linked Immunosorbent Assay; Humans; Nitric Oxide Synthase | 2012 |
Endothelial nitric oxide synthase enhancer for protection of endothelial function from asymmetric dimethylarginine-induced injury in human internal thoracic artery.
Topics: Acetylcholine; Aged; Antioxidants; Arginine; Benzodioxoles; Blotting, Western; Cytoprotection; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Female; Humans; In Vitro Techniques; Indans; Male; Mammary Arteries; Middle Aged; Myography; Nitric Oxide Synthase Type III; Superoxides; Vascular Patency; Vasodilation; Vasodilator Agents | 2012 |
The dual behavior of heat shock protein 70 and asymmetric dimethylarginine in relation to serum CRP levels in type 2 diabetes.
Topics: Adult; Arginine; C-Reactive Protein; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; HSP70 Heat-Shock Proteins; Humans; Inflammation Mediators; Male; Middle Aged; Nitric Oxide | 2012 |
Anti-hypertensive effects of shichimotsukokato in 5/6 nephrectomized Wistar rats mediated by the DDAH-ADMA-NO pathway.
Topics: Amidohydrolases; Animals; Antihypertensive Agents; Arginine; Hypertension; Nephrectomy; Nitric Oxide; Plant Extracts; Protein-Arginine N-Methyltransferases; Rats; Rats, Wistar; Signal Transduction | 2012 |
Role of the human erythrocyte in generation and storage of asymmetric dimethylarginine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acids; Arginine; Biological Transport; Blood Proteins; Chromatography, High Pressure Liquid; Critical Illness; Erythrocytes; Female; Humans; Hydrolysis; In Vitro Techniques; Male; Middle Aged; Proteasome Endopeptidase Complex; Protein Binding; Solid Phase Extraction; Young Adult | 2012 |
Birth by cesarean section is associated with elevated neonatal plasma levels of dimethylarginines.
Topics: Arginine; Cesarean Section; Delivery, Obstetric; Female; Humans; Infant, Newborn; Male; Pregnancy | 2012 |
Pravastatin inhibits advanced glycation end products (AGEs)-induced proximal tubular cell apoptosis and injury by reducing receptor for AGEs (RAGE) level.
Topics: Amidohydrolases; Apoptosis; Arginine; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Fluorobenzenes; Glycation End Products, Advanced; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Tubules, Proximal; Pravastatin; Pyrimidines; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rosuvastatin Calcium; Sulfonamides; Up-Regulation | 2012 |
High tea and vegetable consumption is associated with low ADMA generation in older healthy subjects.
Topics: Aged; Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Coffee; Enzyme Inhibitors; Feeding Behavior; Female; Fruit; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Nitric Oxide Synthase; Reference Values; Risk Factors; Tea; Vegetables | 2012 |
Elevation of serum asymmetrical and symmetrical dimethylarginine in patients with advanced glaucoma.
Topics: Aged; Arginine; Biomarkers; Female; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Male; Nitric Oxide Synthase; Retrospective Studies; Severity of Illness Index; Tandem Mass Spectrometry | 2012 |
Nitric oxide and L-arginine metabolism in a devascularized porcine model of acute liver failure.
Topics: Animals; Arginase; Arginine; Citrulline; Disease Models, Animal; Female; Liver; Liver Failure, Acute; Nitric Oxide; Ornithine; Portacaval Shunt, Surgical; Sus scrofa | 2012 |
HIV replication, inflammation, and the effect of starting antiretroviral therapy on plasma asymmetric dimethylarginine, a novel marker of endothelial dysfunction.
Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Arginine; Biomarkers; CD40 Antigens; Female; HIV Infections; Humans; Inflammation; Male; Middle Aged; P-Selectin; Plasma; Randomized Controlled Trials as Topic; Virus Replication | 2012 |
Plasma asymmetric dimethylarginine and mortality in patients with acute decompensation of chronic heart failure.
Topics: Aged; Arginine; Biomarkers; Endothelium, Vascular; Enzyme Inhibitors; Female; Follow-Up Studies; Greece; Heart Failure; Hospitals, University; Humans; Incidence; Inpatients; Kaplan-Meier Estimate; Length of Stay; Male; Predictive Value of Tests; Prognosis; Risk Assessment; Sensitivity and Specificity; Stroke Volume; Survival Rate | 2012 |
Pilot study of the association of the DDAH2 -449G polymorphism with asymmetric dimethylarginine and hemodynamic shock in pediatric sepsis.
Topics: Adolescent; Amidohydrolases; Arginine; Base Sequence; Child; DNA Primers; Genetic Association Studies; Genotype; Hemodynamics; Humans; Molecular Sequence Data; Nitric Oxide; Pilot Projects; Polymorphism, Single Nucleotide; Prospective Studies; Racial Groups; Sequence Analysis, DNA; Sex Factors; Shock, Septic; Tandem Mass Spectrometry | 2012 |
Asymmetric dimethylarginine: a novel cardiovascular risk factor in end-stage renal disease.
Topics: Arginine; Cardiovascular Diseases; Carotid Intima-Media Thickness; Demography; Female; Humans; Indonesia; Kidney Failure, Chronic; Linear Models; Male; Middle Aged; Renal Dialysis; Risk Factors | 2012 |
Pulmonary hypertension associated with advanced systolic heart failure: dysregulated arginine metabolism and importance of compensatory dimethylarginine dimethylaminohydrolase-1.
Topics: Aged; Amidohydrolases; Arginine; Disease Progression; Female; Heart Failure, Systolic; Humans; Hypertension, Pulmonary; Male; Middle Aged | 2012 |
Nitric oxide synthase, ADMA, SDMA, and nitric oxide activity in the paraventricular nucleus throughout the etiology of renal wrap hypertension.
Topics: Animals; Arginine; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Hypertension, Renal; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley | 2012 |
ADMA and NOS regulation in chronic renal disease: beyond the old rivalry for l-arginine.
Topics: Animals; Arginine; Humans; Male; Nitric Oxide Synthase Type III; Renal Insufficiency, Chronic | 2012 |
Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis.
Topics: Adolescent; Arginine; Carnitine; Case-Control Studies; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Prospective Studies; Sepsis | 2012 |
Asymmetric dimethylarginine in adults with cystathionine β-synthase deficiency.
Topics: Adult; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Endothelium, Vascular; Homocysteine; Homocystinuria; Humans | 2012 |
Dimethylarginine dimethylaminohydrolase 1 regulates nerve growth factor-promoted differentiation of PC12 cells in a nitric oxide-dependent but asymmetric dimethylargenine-independent manner.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arginine; Cell Differentiation; Enzyme Inhibitors; Microtubule-Associated Proteins; Nerve Growth Factor; Neurites; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; PC12 Cells; Rats; RNA, Messenger; Transfection | 2012 |
Human hemoglobin does not contain asymmetric dimethylarginine (ADMA).
Topics: Animals; Arginine; Erythrocytes; Gas Chromatography-Mass Spectrometry; Hemoglobins; Hemolysis; Humans; Linear Models; Mice | 2012 |
Reduced plasma levels of asymmetric di-methylarginine (ADMA) in patients with alcohol dependence normalize during withdrawal.
Topics: Adult; Alcoholism; Arginine; Diagnostic and Statistical Manual of Mental Disorders; Germany; Homocysteine; Humans; Hyperhomocysteinemia; International Classification of Diseases; Male; Middle Aged; Nitric Oxide Synthase; Pilot Projects; Prospective Studies; Risk Factors; Severity of Illness Index; Substance Withdrawal Syndrome; Time Factors; Vascular Diseases | 2012 |
Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine in patients with arteriogenic and non-arteriogenic erectile dysfunction.
Topics: Adult; Arginine; Erectile Dysfunction; Humans; Impotence, Vasculogenic; Male; Middle Aged | 2012 |
Elevated homocysteine and asymmetric dimethyl arginine levels in pulmonary hypertension associated with congenital heart disease.
Topics: Adolescent; Adult; Arginine; Biomarkers; Cardiac Catheterization; Case-Control Studies; Child; Child, Preschool; Echocardiography; Enzyme-Linked Immunosorbent Assay; Familial Primary Pulmonary Hypertension; Heart Defects, Congenital; Hemodynamics; Homocysteine; Humans; Hypertension, Pulmonary; Infant; Nitric Oxide; Predictive Value of Tests; ROC Curve; Sensitivity and Specificity; Statistics, Nonparametric | 2012 |
Relationship between serum asymmetric dimethylarginine and left ventricular structure and function in patients with end‑stage renal disease treated with hemodialysis.
Topics: Arginine; Biomarkers; Echocardiography; Female; Heart Ventricles; Humans; Hypertrophy, Left Ventricular; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Ventricular Dysfunction, Left | 2012 |
Flow-evoked vasodilation is blunted in penile arteries from Zucker diabetic fatty rats.
Topics: Animals; Arginine; Arteries; Cyclooxygenase Inhibitors; Indomethacin; Male; Myography; Nitric Oxide Synthase; Penis; Peptides; Potassium Channels, Calcium-Activated; Rats; Rats, Zucker; Vasodilation | 2012 |
Reduced renal plasma clearance does not explain increased plasma asymmetric dimethylarginine in hypertensive subjects with mild to moderate renal insufficiency.
Topics: Adult; Aged; Arginine; Female; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Kidney Function Tests; Male; Middle Aged; Regional Blood Flow; Renal Insufficiency | 2012 |
The association between serum asymmetric dimethyl arginine levels and a history of gestational diabetes among healthy women.
Topics: Adult; Arginine; Asymptomatic Diseases; Biomarkers; Blood Glucose; Body Mass Index; Cardiovascular Diseases; Case-Control Studies; Diabetes Complications; Diabetes, Gestational; Fasting; Female; Glucose Tolerance Test; Humans; Insulin; Pregnancy; Risk Factors | 2012 |
Plasma asymmetric dimethylarginine in patients with acute decompensation of chronic heart failure.
Topics: Arginine; Enzyme Inhibitors; Female; Heart Failure; Humans; Male | 2012 |
Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I.
Topics: Acetylcarnitine; Adaptor Proteins, Signal Transducing; Animals; Animals, Newborn; Arginine; Biopterins; Disease Models, Animal; Endothelial Cells; Female; GTP Cyclohydrolase; HSP70 Heat-Shock Proteins; Hypertension, Pulmonary; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Pregnancy; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pulmonary Artery; Pulmonary Heart Disease; Sheep; Signal Transduction; Ubiquitin-Protein Ligases; Ubiquitination | 2012 |
Impairment of the extrusion transporter for asymmetric dimethyl-L-arginine: a novel mechanism underlying vasospastic angina.
Topics: Adult; Angina Pectoris; Arginine; Blood Platelets; Coronary Vasospasm; Endothelium, Vascular; Enzyme Inhibitors; Humans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Superoxides | 2012 |
Effect of endoscopic sinus surgery on plasma asymmetric dimethylarginine levels in patients with extensive nasal polyposis.
Topics: Adult; Arginine; Blood Pressure; Endoscopy; Female; Humans; Male; Nasal Polyps; Paranasal Sinuses; Pulmonary Artery | 2012 |
L-arginine and asymmetric dimethylarginine are early predictors for survival in septic patients with acute liver failure.
Topics: Aged; Arginine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Liver Failure, Acute; Male; Middle Aged; Multiple Organ Failure; Nitric Oxide; ROC Curve; Sepsis; Shock, Septic; Time Factors; Treatment Outcome | 2012 |
Paraoxonase lactonase activity (PON-HTLase), asymmetric dimethylarginine (ADMA) and platelet activating factor-acetylhydrolase (PAF-AH) activity in non-obese women with PCOS.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Adolescent; Adult; Arginine; Aryldialkylphosphatase; Body Mass Index; Case-Control Studies; Female; Humans; Obesity; Polycystic Ovary Syndrome; Young Adult | 2012 |
Effect of vitamin D on aortic remodeling in streptozotocin-induced diabetes.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Arginine; Biomarkers; Blood Pressure; Cholecalciferol; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dietary Supplements; Elastic Tissue; Elasticity; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Male; Pulsatile Flow; Radioimmunoassay; Rats; Rats, Wistar; Streptozocin; Time Factors; Vasoconstrictor Agents; Vasodilator Agents; Vitamin D | 2012 |
Asymmetric dimethylarginine reduces nitric oxide donor-mediated dilation of arterioles by activating the vascular renin-angiotensin system and reactive oxygen species.
Topics: Acetophenones; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Arterioles; Catalase; Male; Muscle, Skeletal; NADPH Oxidases; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxidative Stress; Pyrogallol; Rats; Rats, Wistar; Reactive Oxygen Species; Renin-Angiotensin System; Superoxide Dismutase; Vasodilation; Xanthine Oxidase | 2012 |
Oxidative stress in hypertensive children before and after 1 year of antihypertensive therapy.
Topics: Adiposity; Adolescent; Albuminuria; Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arginine; Biomarkers; Blood Pressure; C-Reactive Protein; Carotid Artery Diseases; Carotid Intima-Media Thickness; Chi-Square Distribution; Child; Child, Preschool; Cholesterol, LDL; Female; Glutathione Peroxidase; Humans; Hypertension; Hypertrophy, Left Ventricular; Insulin Resistance; Lipoproteins, LDL; Male; Metabolic Syndrome; Oxidative Stress; Poland; Severity of Illness Index; Thiobarbituric Acid Reactive Substances; Time Factors; Treatment Outcome | 2012 |
Assessment of endothelial function in patients with nonalcoholic fatty liver disease.
Topics: Adult; Arginine; Atherosclerosis; Brachial Artery; Carotid Arteries; Carotid Intima-Media Thickness; Case-Control Studies; Early Diagnosis; Endothelium, Vascular; Fatty Liver; Female; Humans; Insulin Resistance; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Practice Guidelines as Topic; Predictive Value of Tests; Severity of Illness Index; Vascular Diseases; Vasodilation | 2013 |
Plasma fetuin-A is associated with endothelial dysfunction and subclinical atherosclerosis in subjects with nonalcoholic fatty liver disease.
Topics: Adiponectin; Adult; alpha-2-HS-Glycoprotein; Arginine; Atherosclerosis; Carotid Artery Diseases; Carotid Intima-Media Thickness; Fatty Liver; Female; Humans; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Young Adult | 2013 |
Diagnostic value of plasma asymmetric and symmetric dimethylarginine levels in liver transplant recipients.
Topics: Alanine Transaminase; Arginine; Aspartate Aminotransferases; Biomarkers; Cadaver; Fibrosis; Humans; Kidney Transplantation; Predictive Value of Tests; Renal Insufficiency, Chronic | 2012 |
The effect of valsartan and nebivolol treatment on ADMA and pentraxin-3 levels in hypertensive patients.
Topics: Adult; Antihypertensive Agents; Arginine; Benzopyrans; C-Reactive Protein; Ethanolamines; Female; Humans; Hypertension; Male; Middle Aged; Nebivolol; Serum Amyloid P-Component; Tetrazoles; Valine; Valsartan | 2012 |
Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (CAT1).
Topics: Arginine; Biological Transport; Biomarkers; Cardiovascular Diseases; Cationic Amino Acid Transporter 1; Gene Expression; HEK293 Cells; Humans; Kinesics; Metformin; Risk | 2012 |
Relationship between plasma asymmetric dimethylarginine level and autonomic dysfunction in diabetic patients.
Topics: Administration, Oral; Arginine; Autonomic Nervous System Diseases; Case-Control Studies; Diabetes Mellitus, Type 2; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged | 2012 |
Aqueous humour and serum concentration of asymmetric dimethyl arginine in pseudoexfoliation syndrome.
Topics: Aged; Aqueous Humor; Arginine; Cataract; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Exfoliation Syndrome; Female; Gonioscopy; Humans; Intraocular Pressure; Male; Nitric Oxide Synthase; Tonometry, Ocular | 2012 |
Screening of substrates of protein arginine methyltransferase 1 in glioma.
Topics: Arginine; Cell Line, Tumor; Chromatography, Liquid; Glioma; Humans; Immunoprecipitation; Protein-Arginine N-Methyltransferases; Repressor Proteins; Substrate Specificity; Tandem Mass Spectrometry | 2012 |
Proteinuria elevates asymmetric dimethylarginine levels via protein arginine methyltransferase-1 overexpression in a rat model of nephrotic syndrome.
Topics: Acetylcysteine; Animals; Antioxidants; Arginine; Cells, Cultured; Disease Models, Animal; Doxorubicin; Epithelial Cells; Gene Expression Regulation, Enzymologic; Humans; Kidney Tubules, Proximal; Male; Nephrotic Syndrome; Oxidative Stress; Protein-Arginine N-Methyltransferases; Proteinuria; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Serum Albumin; Time Factors | 2012 |
Do cardiac risk factors affect the homocysteine and asymmetric dimethylarginine relationship in patients with coronary artery diseases?
Topics: Adult; Aged; Arginine; Atherosclerosis; Coronary Artery Disease; Female; Homocysteine; Humans; Male; Middle Aged; Regression Analysis; Risk Factors | 2012 |
Regulation of endothelial nitric oxide synthase and asymmetric dimethylarginine by matrine attenuates isoproterenol-induced acute myocardial injury in rats.
Topics: Alkaloids; Amidohydrolases; Animals; Arginine; Catechol O-Methyltransferase; Glycogen Synthase Kinases; Heart Ventricles; Isoproterenol; Male; Matrines; Myocardial Ischemia; Myocardium; Necrosis; Nitric Oxide Synthase Type III; Phosphorylation; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-akt; Quinolizines; Rats; Rats, Sprague-Dawley; Sophora | 2012 |
The role of homocysteine, asymmetric dimethylarginine and nitric oxide in pre-eclampsia.
Topics: Adult; Arginine; Case-Control Studies; Female; Homocysteine; Humans; Nitric Oxide; Pre-Eclampsia; Pregnancy; Young Adult | 2012 |
Asymmetric dimethylarginine, an endogenous NOS inhibitor, is actively metabolized in rat erythrocytes.
Topics: Amidohydrolases; Amino Acid Sequence; Animals; Arginine; Catalase; Enzyme Inhibitors; Erythrocytes; Gene Expression; Humans; Male; Mice; Molecular Sequence Data; Nitric Oxide; Nitric Oxide Synthase; Protein Binding; Protein-Arginine N-Methyltransferases; Rats | 2012 |
The CSF concentration of ADMA, but not of ET-1, is correlated with the occurrence and severity of cerebral vasospasm after subarachnoid hemorrhage.
Topics: Adult; Arginine; Brain Ischemia; Endothelin-1; Female; Humans; Male; Middle Aged; Nitric Oxide; Retrospective Studies; Severity of Illness Index; Subarachnoid Hemorrhage; Vasodilation; Vasospasm, Intracranial | 2012 |
Biological signatures of asymptomatic extra- and intracranial atherosclerosis: the Barcelona-AsIA (Asymptomatic Intracranial Atherosclerosis) study.
Topics: Aged; Arginine; Biomarkers; C-Reactive Protein; Carotid Artery Diseases; Cohort Studies; Cross-Sectional Studies; Diabetes Complications; Female; Humans; Insulin Resistance; Intracranial Arteriosclerosis; Longitudinal Studies; Male; Metabolic Syndrome; Middle Aged; Plasminogen Activator Inhibitor 1; Regression Analysis; Resistin; Risk Factors; Spain | 2012 |
Clinical remission following treatment with tumour necrosis factor-alpha antagonists is not accompanied by changes in asymmetric dimethylarginine in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arginine; Arthritis, Rheumatoid; Biomarkers; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Remission Induction; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
[The role of asymmetric dimethylarginine in the regulation of nitric oxide level in rats with acute renal injury].
Topics: Acute Kidney Injury; Amidohydrolases; Animals; Arginine; Glycerol; Kidney; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar | 2012 |
Mechanism of cellular oxidation stress induced by asymmetric dimethylarginine.
Topics: Arginine; Biopterins; Enzyme Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; Lysine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress | 2012 |
Elevated asymmetric dimethylarginine in young adult survivors of childhood acute lymphoblastic leukemia: a preliminary report.
Topics: Adolescent; Adult; Arginine; Cardiovascular Diseases; Female; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Survivors | 2012 |
Binding of the heterogeneous ribonucleoprotein K (hnRNP K) to the Epstein-Barr virus nuclear antigen 2 (EBNA2) enhances viral LMP2A expression.
Topics: Antibodies, Monoclonal; Antibody Specificity; Arginine; Cell Line; DNA; Epstein-Barr Virus Infections; Epstein-Barr Virus Nuclear Antigens; Gene Expression Regulation, Viral; Herpesvirus 4, Human; Heterogeneous-Nuclear Ribonucleoprotein K; Humans; Immunoprecipitation; Methylation; Molecular Sequence Data; Multiprotein Complexes; Mutant Proteins; Promoter Regions, Genetic; Protein Binding; Protein Transport; Repetitive Sequences, Amino Acid; snRNP Core Proteins; Transfection; Viral Matrix Proteins; Viral Proteins | 2012 |
Inflammatory processes and effects of continuous positive airway pressure (CPAP) in overlap syndrome.
Topics: Arginine; C-Reactive Protein; Continuous Positive Airway Pressure; Humans; Inflammation; Inflammation Mediators; Male; Middle Aged; Polysomnography; Pulmonary Disease, Chronic Obstructive; Sleep Apnea, Obstructive; Snoring; Spirometry; Tumor Necrosis Factor-alpha | 2013 |
The protection by heme oxygenase-1 induction against thioacetamide-induced liver toxicity is associated with changes in arginine and asymmetric dimethylarginine.
Topics: Alanine Transaminase; Animals; Arginase; Arginine; Aspartate Aminotransferases; Blotting, Western; Enzyme Induction; Glutathione; Glutathione Peroxidase; Heme Oxygenase-1; Liver; Liver Diseases; Male; Malondialdehyde; Nitric Oxide Synthase Type II; Protective Agents; Rats; Rats, Wistar; Superoxide Dismutase; Thioacetamide | 2013 |
Asymmetric dimethylarginine is strongly associated with cognitive dysfunction and brain MR spectroscopic abnormalities in cirrhosis.
Topics: Adult; Arginine; Aspartic Acid; Biomarkers; Brain; Cognition Disorders; Cross-Sectional Studies; Female; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Inositol; Liver Cirrhosis; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prospective Studies | 2013 |
AVE3085 protects coronary endothelium from the impairment of asymmetric dimethylarginine by activation and recoupling of eNOS.
Topics: Animals; Arginine; Benzodioxoles; Cardiotonic Agents; Coronary Vessels; Endothelium, Vascular; In Vitro Techniques; Indans; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxygen; Superoxides; Swine; Vasodilation | 2012 |
Diagnostical significance of dimethylarginine in the development of hepatorenal syndrome in patients with alcoholic liver cirrhosis.
Topics: Adult; Aged; Arginine; Biomarkers; Creatinine; Disease Progression; Hepatorenal Syndrome; Humans; Liver Cirrhosis, Alcoholic; Male; Middle Aged | 2012 |
Subarachnoid haemorrhage induces an inflammatory response followed by a delayed persisting increase in asymmetric dimethylarginine.
Topics: Acute-Phase Reaction; Arginine; Biomarkers; C-Reactive Protein; Case-Control Studies; Female; Humans; Inflammation; Male; Middle Aged; Subarachnoid Hemorrhage | 2012 |
Serum asymmetric dimethylarginine, apelin, and tumor necrosis factor-α levels in non-obese women with polycystic ovary syndrome.
Topics: Apelin; Arginine; Body Mass Index; Case-Control Studies; Female; Humans; Hyperandrogenism; Intercellular Signaling Peptides and Proteins; Polycystic Ovary Syndrome; Tumor Necrosis Factor-alpha; Young Adult | 2012 |
Plasma concentrations of asymmetric dimethylarginine, nitric oxide and homocysteine in patients with slow coronary flow.
Topics: Arginine; Case-Control Studies; Coronary Angiography; Coronary Circulation; Demography; Female; Hemorheology; Homocysteine; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Nitric Oxide | 2012 |
Assessment of the endothelial functions in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Aorta, Thoracic; Arginine; Disease Models, Animal; Endothelium, Vascular; Hydrogen Sulfide; Hypertension, Pulmonary; Iloprost; Male; Monocrotaline; Nitric Oxide; Piperazines; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Vasodilation; Vasodilator Agents | 2013 |
Oxidative stress in patients with essential hypertension: a comparison of dippers and non-dippers.
Topics: Antioxidants; Arginine; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Female; Humans; Hypertension; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Prospective Studies; Tyrosine | 2013 |
Estradiol, acting through estrogen receptor alpha, restores dimethylarginine dimethylaminohydrolase activity and nitric oxide production in oxLDL-treated human arterial endothelial cells.
Topics: Amidohydrolases; Arginine; Blotting, Western; Cells, Cultured; Endothelium, Vascular; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens, Non-Steroidal; Humans; Isoenzymes; Lipoproteins, LDL; Nitric Oxide; Nitric Oxide Synthase Type III; Protein Stability; Protein-Arginine N-Methyltransferases; Receptors, Estrogen; Receptors, G-Protein-Coupled; Repressor Proteins; Umbilical Arteries | 2013 |
Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome.
Topics: Adult; Arginine; Biomarkers; Cardiovascular Diseases; Female; Humans; Intercellular Adhesion Molecule-1; Plasminogen Activator Inhibitor 1; Polycystic Ovary Syndrome; Vascular Cell Adhesion Molecule-1; Waist Circumference; Weight Loss | 2012 |
Nitric oxide and carbon monoxide production and metabolism in preeclampsia.
Topics: Adult; Amidohydrolases; Arginine; Biomarkers; Blotting, Western; Carbon Monoxide; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Heme Oxygenase-1; Humans; Nitric Oxide; Placenta; Pre-Eclampsia; Predictive Value of Tests; Pregnancy; Prospective Studies; Young Adult | 2013 |
The L-arginine/asymmetric dimethylarginine ratio is improved by anti-tumor necrosis factor-α therapy in inflammatory arthropathies. Associations with aortic stiffness.
Topics: Adult; Antirheumatic Agents; Aorta; Arginine; Arthritis, Psoriatic; Arthritis, Rheumatoid; Blood Pressure; Carotid Intima-Media Thickness; Female; Humans; Male; Middle Aged; Pulse Wave Analysis; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha; Vascular Stiffness | 2012 |
INF-β1b therapy modulates L-arginine and nitric oxide metabolism in patients with relapse remittent multiple sclerosis.
Topics: Adult; Arginase; Arginine; Biomarkers; Drug Monitoring; Female; Follow-Up Studies; Humans; Inflammation; Interferon beta-1b; Interferon-beta; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Nitrates; Nitric Oxide; Nitrites; Nitroso Compounds; Severity of Illness Index; Sulfhydryl Compounds; Tyrosine; Young Adult | 2012 |
Actin cytoskeleton-dependent pathways for ADMA-induced NF-κB activation and TGF-β high expression in human renal glomerular endothelial cells.
Topics: Actins; Arginine; Base Sequence; Blotting, Western; Cells, Cultured; Cytoskeleton; DNA Primers; Electrophoretic Mobility Shift Assay; Endothelium; Humans; Kidney Glomerulus; NF-kappa B; Real-Time Polymerase Chain Reaction; Transforming Growth Factor beta | 2012 |
Compensatory feto-placental upregulation of the nitric oxide system during fetal growth restriction.
Topics: Adaptation, Physiological; Adult; Arginine; Endothelial Cells; Endothelium, Vascular; Female; Fetal Blood; Fetal Growth Retardation; Fetus; Gene Expression Profiling; Hemoglobins; Humans; Infant, Low Birth Weight; Infant, Newborn; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Placenta; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; Ultrasonography; Umbilical Arteries; Umbilical Veins; Up-Regulation | 2012 |
Feto-placental nitric oxide, asymmetric dimethylarginine and vascular endothelial growth factor (VEGF) levels and VEGF gene polymorphisms in severe preeclampsia.
Topics: Adolescent; Adult; Arginine; Case-Control Studies; Female; Fetal Blood; Genetic Predisposition to Disease; Humans; Infant, Newborn; Nitric Oxide; Pilot Projects; Placenta; Placental Circulation; Polymorphism, Single Nucleotide; Pre-Eclampsia; Pregnancy; Severity of Illness Index; Umbilical Veins; Vascular Endothelial Growth Factor A; Young Adult | 2013 |
Asymmetrical dimethylarginine antagonizes glutamate-induced apoptosis in PC12 cells.
Topics: Animals; Apoptosis; Arginine; Caspase 3; Glutamic Acid; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats | 2013 |
Changes in ghrelin and asymmetrical dimethylarginine in obese Mexican adolescents after six-month lifestyle intervention.
Topics: Adolescent; Arginine; Body Mass Index; Child; Eating; Feeding Behavior; Female; Ghrelin; Humans; Insulin Resistance; Life Style; Male; Mexico; Obesity; Surveys and Questionnaires | 2013 |
Recognition of asymmetrically dimethylated arginine by TDRD3.
Topics: Amino Acid Sequence; Amino Acids; Arginine; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Mutation; Protein Structure, Tertiary; Proteins; Sequence Alignment | 2012 |
Asymmetric and symmetric dimethylarginine and risk of secondary cardiovascular disease events and mortality in patients with stable coronary heart disease: the KAROLA follow-up study.
Topics: Aged; Arginine; Biomarkers; Cause of Death; Chromatography, Liquid; Coronary Disease; Female; Follow-Up Studies; Germany; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Recurrence; Risk Assessment; Risk Factors; Tandem Mass Spectrometry; Time Factors | 2013 |
Exploring disease activity and cardiovascular events by raised serum asymmetric dimethyl arginine among systemic lupus erythematosus patients.
Topics: Adult; Arginine; Cardiovascular Diseases; Cholesterol; Complement C3; Cross-Sectional Studies; Egypt; Female; Humans; Logistic Models; Lupus Erythematosus, Systemic; Male; Surveys and Questionnaires | 2011 |
Asymmetric dimethylarginine predicts clinical outcomes in ischemic chronic heart failure.
Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Chi-Square Distribution; Chromatography, High Pressure Liquid; Coronary Angiography; Disease-Free Survival; Female; Heart Failure; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Myocardial Ischemia; Natriuretic Peptide, Brain; Peptide Fragments; Prognosis; Proportional Hazards Models; Risk Assessment; Risk Factors; Stroke Volume; Taiwan; Time Factors; Ultrasonography; Up-Regulation; Ventricular Function, Left | 2012 |
Dimethylarginine dimethylaminohydrolase1 is an organ-specific mediator of end organ damage in a murine model of hypertension.
Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Heart; Humans; Hypertension; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2012 |
Left atrial volume index and aortic stiffness index in adult hemodialysed patients--link between compliance and pressure mediated by endothelium dysfunction; a cross-sectional study.
Topics: Adult; Aged; Arginine; Cross-Sectional Studies; Echocardiography; Endothelium, Vascular; Female; Heart Atria; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Nitric Oxide; Peptide Fragments; Renal Dialysis; Troponin T; Vascular Stiffness | 2012 |
Chronic renal impairment and DDAH2-1151 A/C polymorphism determine ADMA levels in type 2 diabetic subjects.
Topics: Aged; Amidohydrolases; Arginine; Case-Control Studies; Diabetes Complications; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Kidney Function Tests; Male; Middle Aged; Nitric Oxide; Polymorphism, Genetic; Prognosis; Renal Insufficiency, Chronic; Risk Factors | 2013 |
Asymmetric dimethylarginine and carotid atherosclerosis in Type 2 diabetes mellitus.
Topics: Adult; Aged; Arginine; Carotid Artery Diseases; Case-Control Studies; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Prognosis | 2012 |
ADMA, SDMA and L-arginine/ADMA ratio but not DDAH genetic polymorphisms are reliable predictors of diabetic nephropathy progression as identified by competing risk analysis.
Topics: Adult; Aged; Amidohydrolases; Arginine; Cross-Sectional Studies; Czech Republic; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Female; Follow-Up Studies; Humans; Male; Methylation; Middle Aged; Multivariate Analysis; Polymorphism, Single Nucleotide; Predictive Value of Tests; Prognosis; Reproducibility of Results; Risk Factors | 2012 |
Impact of ADMA, endothelial progenitor cells and traditional cardiovascular risk factors on pulse wave velocity among prediabetic individuals.
Topics: Adult; Aged; Arginine; Biomarkers; Blood Glucose; Cardiovascular Diseases; Carotid Arteries; Cholesterol, LDL; Cross-Sectional Studies; Endothelial Cells; Fasting; Female; Femoral Artery; Glucose Tolerance Test; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Prediabetic State; Predictive Value of Tests; Pulse Wave Analysis; Risk Assessment; Risk Factors; Stem Cells; Vascular Stiffness | 2012 |
Glucagon-like peptide-1 receptor agonist inhibits asymmetric dimethylarginine generation in the kidney of streptozotocin-induced diabetic rats by blocking advanced glycation end product-induced protein arginine methyltranferase-1 expression.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drug Evaluation, Preclinical; Exenatide; Gene Expression Regulation, Enzymologic; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycation End Products, Advanced; Humans; Hypertrophy; Hypoglycemic Agents; Kidney; Kidney Glomerulus; Kidney Tubules; Macrophages; Male; Peptides; Protein-Arginine N-Methyltransferases; Rats; Rats, Wistar; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Receptors, Glucagon; Receptors, Immunologic; Repressor Proteins; RNA, Messenger; Venoms | 2013 |
Protection of DDAH2 overexpression against homocysteine-induced impairments of DDAH/ADMA/NOS/NO pathway in endothelial cells.
Topics: Amidohydrolases; Arginine; Cells, Cultured; Endothelium; Gene Expression; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Hyperhomocysteinemia; L-Lactate Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase Type III; Signal Transduction | 2012 |
Serum asymmetric dimethylarginine levels are independently associated with procollagen III N-terminal peptide in nonalcoholic fatty liver disease patients.
Topics: Adult; Aged; Arginine; Fatty Liver; Female; Humans; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Peptide Fragments; Procollagen; Serum | 2014 |
The relationship of plasma ADMA levels with cardiac functions and metabolic parameters in peritoneal dialysis patients.
Topics: Adolescent; Aged; Arginine; Aspirin; Body Mass Index; Cardiovascular Diseases; Cross-Sectional Studies; Echocardiography; Heart; Humans; Hypertension; Middle Aged; Peritoneal Dialysis; Risk Factors | 2013 |
Aminoguanidine attenuates hypertension, whereas 7-nitroindazole exacerbates kidney damage in spontaneously hypertensive rats: the role of nitric oxide.
Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Citrulline; Guanidines; Hypertension; Indazoles; Kidney Diseases; Male; Nitric Oxide; Nitric Oxide Synthase Type I; Rats; Rats, Inbred SHR; Sodium Chloride, Dietary; Up-Regulation | 2013 |
Asymmetric dimethylarginine plasma levels and endothelial function in newly diagnosed type 2 diabetic patients.
Topics: Arginine; Blood Pressure; Case-Control Studies; Diabetes Complications; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Humans; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Risk Factors | 2012 |
Associations between endogenous dimethylarginines and renal function in healthy children and adolescents.
Topics: Adolescent; Arginine; Child; Child, Preschool; Creatinine; Female; Glomerular Filtration Rate; Healthy Volunteers; Humans; Kidney; Kidney Function Tests; Lipids; Male | 2012 |
An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype.
Topics: Adolescent; Adult; Age of Onset; Aged; Arginine; Asthma; Body Mass Index; Cross-Sectional Studies; Forced Expiratory Volume; Humans; Middle Aged; Nitric Oxide; Obesity; Phenotype; Young Adult | 2013 |
The L-Arginine-asymmetric dimethylarginine ratio is an independent predictor of mortality in dilated cardiomyopathy.
Topics: Arginine; Biomarkers; Cardiomyopathies; Cardiomyopathy, Dilated; Chromatography, Liquid; Creatinine; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Myocardial Ischemia; Natriuretic Peptide, Brain; Peptide Fragments; Severity of Illness Index; Tandem Mass Spectrometry | 2012 |
Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, interacts with gastric oxidative metabolism and enhances stress-induced gastric lesions.
Topics: Aldehydes; Animals; Arginine; Enzyme Inhibitors; Gastric Mucosa; Glutathione Peroxidase; Interleukin-1beta; Lipid Peroxidation; Male; Malondialdehyde; Nitric Oxide Synthase; Rats; Rats, Wistar; Regional Blood Flow; Restraint, Physical; Stomach Ulcer; Stress, Psychological; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2012 |
Asymmetrical dimethylarginine level is independently associated with circulating levels of RAGE and PEDF.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Cross-Sectional Studies; Eye Proteins; Female; Humans; Male; Middle Aged; Nerve Growth Factors; Nitric Oxide Synthase; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Serpins | 2013 |
Effect of chronic elevated asymmetric dimethylarginine (ADMA) levels on granulopoiesis.
Topics: Animals; Arginine; Blood Cell Count; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Granulocytes; Hematopoiesis; Killer Cells, Natural; Leukocytes; Male; Rats; Rats, Sprague-Dawley; Time Factors | 2013 |
Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow.
Topics: Adenosine Triphosphate; Animals; Arginine; Carnitine; Disease Models, Animal; Endothelial Cells; Heart Defects, Congenital; Homeostasis; Hypertension, Pulmonary; Lung; Mitochondria; Nitric Oxide; Nitric Oxide Synthase Type III; Pulmonary Circulation; Regional Blood Flow; Sheep; Signal Transduction | 2013 |
Asymmetric dimethylarginine induces endothelial nitric-oxide synthase mitochondrial redistribution through the nitration-mediated activation of Akt1.
Topics: Animals; Arginine; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Humans; Mice; Mitochondria; Mitochondrial Proteins; Nitric Oxide Synthase Type III; Oxygen Consumption; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Sheep | 2013 |
Assessment of atherosclerosis risk due to the homocysteine-asymmetric dimethylarginine-nitric oxide cascade in children taking antiepileptic drugs.
Topics: Adolescent; Anticonvulsants; Arginine; Atherosclerosis; Biomarkers; Carbamazepine; Child; Epilepsy; Female; Homocysteine; Humans; Male; Nitric Oxide; Oxcarbazepine; Prospective Studies; Risk Factors; Valproic Acid | 2013 |
Differences in the association between maternal serum homocysteine and ADMA levels in women with pregnancies complicated by preeclampsia and/or intrauterine growth restriction.
Topics: Adult; Arginine; Case-Control Studies; Female; Fetal Growth Retardation; Homocysteine; Humans; Pre-Eclampsia; Pregnancy; Young Adult | 2013 |
Impact of ADMA (asymmetric dimethylarginine) on physiology with respect to diabetes mellitus and respiratory system BEAS-2B cells (human bronchial epithelial cells).
Topics: Animals; Arginine; Blood Glucose; Cell Line; Chemokine CXCL2; Diabetes Mellitus; Epithelial Cells; Female; Humans; Insulin; Insulin Resistance; Insulin-Secreting Cells; Interleukin-6; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Respiratory Mucosa; Trachea; Tumor Necrosis Factor-alpha | 2013 |
Probing AGXT2 enzyme activity in mouse tissue by applying stable isotope-labeled asymmetric dimethyl arginine as substrate.
Topics: Animals; Arginine; Chromatography, Liquid; Enzyme Stability; Guanidines; Hydrogen-Ion Concentration; Isotope Labeling; Keto Acids; Kidney; Liver; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Nitric Oxide; Reproducibility of Results; Tandem Mass Spectrometry; Transaminases | 2012 |
Vaspin increases nitric oxide bioavailability through the reduction of asymmetric dimethylarginine in vascular endothelial cells.
Topics: Animals; Arginine; Blotting, Western; Cells, Cultured; Electrophoretic Mobility Shift Assay; Endothelial Cells; Humans; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Serpins | 2012 |
Melatonin regulates L-arginine transport and NADPH oxidase in young rats with bile duct ligation: role of protein kinase C.
Topics: Animals; Arginase; Arginine; Biological Transport; Cationic Amino Acid Transporter 1; Cholestasis, Extrahepatic; Common Bile Duct; Disease Models, Animal; Female; Injections, Intraperitoneal; Kidney; Ligation; Liver; Male; Melatonin; NADPH Oxidases; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase Inhibitors; Protein Transport; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2013 |
Disruption of asymmetric dimethylarginine-induced RelA/P65 association with actin in endothelial cells.
Topics: Actins; Active Transport, Cell Nucleus; Arginine; Cell Nucleus; Cytoplasm; Endothelial Cells; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; NF-kappa B; Promoter Regions, Genetic; Protein Binding; Time Factors; Transcription Factor RelA; Vascular Cell Adhesion Molecule-1 | 2013 |
Effects of asymmetric dimethylarginine on inflammatory cytokines (TNF-α, IL-6 and IL-10) in rats.
Topics: Animals; Arginine; Dose-Response Relationship, Drug; Inflammation; Interleukin-10; Interleukin-6; Male; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2015 |
Predictors of asymmetric dimethylarginine levels in patients with rheumatoid arthritis: the role of insulin resistance.
Topics: Adult; Aged; Arginine; Arthritis, Rheumatoid; Female; Homeostasis; Humans; Insulin Resistance; Male; Middle Aged | 2013 |
Clinical-biological phenotyping beyond inflammation in asthma delivers.
Topics: Age of Onset; Arginine; Asthma; Humans; Obesity | 2013 |
Asymmetric dimethyloarginin (ADMA) concentration in the aqueous humor of patients with exfoliation syndrome or exfoliative glaucoma.
Topics: Aged; Aqueous Humor; Arginine; Cataract; Cataract Extraction; Exfoliation Syndrome; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Oxidative Stress | 2013 |
Effect of atrial fibrillation on atrial thrombogenesis in humans: impact of rate and rhythm.
Topics: Aged; Antithrombin III; Arginine; Atrial Fibrillation; Catheter Ablation; CD40 Ligand; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Heart Atria; Heart Rate; Humans; Male; Middle Aged; P-Selectin; Peptide Hydrolases; Platelet Activation; Risk Assessment; Risk Factors; Statistics as Topic; Stroke; Thrombosis | 2013 |
MS³ fragmentation patterns of monomethylarginine species and the quantification of all methylarginine species in yeast using MRM³.
Topics: Arginine; Cell Cycle; Chromatography, Liquid; Humans; Ions; Mass Spectrometry; Methylation; Mutation; Protein Processing, Post-Translational; Proteomics; Saccharomyces cerevisiae; Tandem Mass Spectrometry | 2013 |
A novel mechanism of formaldehyde neurotoxicity: inhibition of hydrogen sulfide generation by promoting overproduction of nitric oxide.
Topics: Animals; Arginine; Blotting, Western; Cystathionine beta-Synthase; Enzyme-Linked Immunosorbent Assay; Formaldehyde; Gene Knockdown Techniques; Gene Silencing; Hydrogen Sulfide; Nitric Oxide; Nitric Oxide Synthase; PC12 Cells; Rats | 2013 |
Transsulfuration pathway thiols and methylated arginines: the Hunter Community Study.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Aging; Amidohydrolases; Arginine; Australia; C-Reactive Protein; Cardiovascular Diseases; Cohort Studies; Community Medicine; Cysteine; Dipeptides; Female; Glutathione; Homocysteine; Humans; Male; Middle Aged; Taurine | 2013 |
Decrease of asymmetric dimethylarginine predicts acute mountain sickness.
Topics: Acute Disease; Adult; Altitude Sickness; Arginine; Disease Susceptibility; Echocardiography, Doppler; Enzyme Inhibitors; Humans; Hypoxia; Male; Mountaineering; Nitric Oxide Synthase; Pulmonary Wedge Pressure; Research Design; Risk Assessment; Time Factors | 2012 |
Accelerated fat cell aging links oxidative stress and insulin resistance in adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Arginine; Biomarkers; Cell Differentiation; Gene Expression; Glucose; Glucose Oxidase; Hydrogen Peroxide; Insulin Resistance; Interleukin-6; Mice; Oxidative Stress; p21-Activated Kinases; Reactive Oxygen Species; Telomere; Telomere Shortening; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2013 |
Quantification of arginine and dimethylated arginines in human plasma by field-amplified sample injection capillary electrophoresis UV detection.
Topics: Arginine; Buffers; Calibration; Electrophoresis, Capillary; Humans; Ultraviolet Rays | 2013 |
Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma.
Topics: Adaptor Proteins, Signal Transducing; Arginine; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 4; Extracellular Signal-Regulated MAP Kinases; Female; Gene Amplification; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Liposarcoma; Male; Membrane Proteins; Middle Aged; Neoplasm Grading; Phenylurea Compounds; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-mdm2; Pyrimidines; Receptor, Fibroblast Growth Factor, Type 2; Receptor, Fibroblast Growth Factor, Type 3; Receptor, Fibroblast Growth Factor, Type 4; Receptors, Fibroblast Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction | 2013 |
[Protective effect of insulin-like growth factor-1 on vascular endothelial function in hypercholesterolemia and the underlying mechanism].
Topics: Adult; Arginine; Case-Control Studies; Cells, Cultured; Endothelium, Vascular; Female; Human Umbilical Vein Endothelial Cells; Humans; Hypercholesterolemia; Insulin-Like Growth Factor I; Lipoproteins, LDL; Male; Middle Aged; Nitric Oxide; Protective Agents; Vasodilation | 2013 |
Nitric oxide in afferent arterioles after uninephrectomy depends on extracellular L-arginine.
Topics: Angiotensin II; Animals; Arginine; Arterioles; Blood Pressure; Body Weight; Enzyme Inhibitors; Extracellular Space; Glomerular Filtration Rate; Homeostasis; Male; Nephrectomy; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Rats; Rats, Wistar; Renal Circulation; Vasoconstrictor Agents | 2013 |
Asymmetric dimethylarginine is associated with developmental programming of adult kidney disease and hypertension in offspring of streptozotocin-treated mothers.
Topics: Animals; Arginine; Blotting, Western; Electron Spin Resonance Spectroscopy; Female; Hypertension; Kidney Diseases; Pregnancy; Rats; Rats, Sprague-Dawley; Streptozocin | 2013 |
Asymmetric dimethylarginine in exhaled breath condensate and serum of children with asthma.
Topics: Adolescent; Arginine; Asthma; Breath Tests; Case-Control Studies; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Exhalation; Female; Humans; Male; Nitric Oxide; Oxidative Stress; Spirometry; Tandem Mass Spectrometry | 2013 |
Asymmetric dimethylarginine (ADMA) and L-arginine levels in children with glycogen storage disease type I.
Topics: Adolescent; Arginine; Child; Child, Preschool; Fatty Acids; Female; Glycogen Storage Disease Type I; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipid Peroxidation; Male | 2013 |
Heat-assisted extraction for the determination of methylarginines in serum by CE.
Topics: Arginine; Cardiovascular Diseases; Electrophoresis, Capillary; Hot Temperature; Humans; omega-N-Methylarginine; Solid Phase Extraction | 2013 |
Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs.
Topics: Arginine; Cell Line; Gene Knockdown Techniques; Humans; Methylation; Protein-Arginine N-Methyltransferases; Proteolysis; Repressor Proteins; Substrate Specificity | 2013 |
Effects of salvianolic acid A on plasma and tissue dimethylarginine levels in a rat model of myocardial infarction.
Topics: Amidohydrolases; Animals; Arginine; Caffeic Acids; Chromatography, High Pressure Liquid; Creatinine; Disease Models, Animal; Heart Ventricles; Kidney; Lactates; Liver; Male; Myocardial Infarction; Proton Pump Inhibitors; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2013 |
Glial-cell-mediated re-induction of the blood-brain barrier phenotype in brain capillary endothelial cells: a differential gel electrophoresis study.
Topics: Animals; Arginine; Blood-Brain Barrier; Cattle; Culture Media; Electrophoresis, Gel, Two-Dimensional; Endothelial Cells; Immunoblotting; Neuroglia; Phenotype; Rats; Reproducibility of Results | 2013 |
The methylarginines NMMA, ADMA, and SDMA are ubiquitous constituents of the main vegetables of human nutrition.
Topics: Arginine; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Vegetables | 2013 |
Association of lipid peroxidation with endothelial dysfunction in patients with overt hypothyroidism.
Topics: Adult; Antioxidants; Arginine; Cardiovascular Diseases; Case-Control Studies; Endothelium, Vascular; Female; Humans; Hypothyroidism; Lipid Peroxidation; Male; Malondialdehyde; Nitric Oxide; Risk Factors | 2013 |
Comparison of plasma viscosity as a marker of endothelial dysfunction with nitric oxide and asymmetric dimethylarginine in subjects with dyslipidemia.
Topics: Adult; Aged; Arginine; Atherosclerosis; Biomarkers; Blood Viscosity; Dyslipidemias; Endothelium, Vascular; Female; Humans; Lipoproteins, LDL; Male; Middle Aged; Nitric Oxide | 2014 |
Low plasma arginine:asymmetric dimethyl arginine ratios predict mortality after intracranial aneurysm rupture.
Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Arginine; Biomarkers; Blood Flow Velocity; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Vasospasm, Intracranial | 2013 |
Editorial (hot topic: cardiovascular disease biomarkers: from tradition to modernity).
Topics: Adiponectin; Arginine; Biomarkers; Cardiovascular Diseases; Cystatin C; Endothelins; Glycopeptides; Humans; MicroRNAs; Natriuretic Peptide, Brain; Peptide Fragments; Peroxidase; Predictive Value of Tests; Troponin | 2013 |
Roles of insulin, age, and asymmetric dimethylarginine on nitric oxide synthesis in vivo.
Topics: Adult; Age Factors; Aged; Arginine; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Humans; Hypercholesterolemia; Hypertension; Insulin; Insulin Resistance; Male; Middle Aged; Nitric Oxide | 2013 |
The value of serum asymmetric dimethylarginine levels for the determination of masked hypertension in patients with diabetes mellitus.
Topics: Adult; Arginine; Biomarkers; Blood Pressure Monitoring, Ambulatory; Chi-Square Distribution; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Fluorescence; Humans; Hypertension; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Predictive Value of Tests; Prevalence; Risk Factors; Turkey | 2013 |
Asymmetric dimethylarginine levels in children with sickle cell disease and its correlation to tricuspid regurgitant jet velocity.
Topics: Adolescent; Anemia, Sickle Cell; Arginine; Blood Transfusion; Case-Control Studies; Child; Cross-Sectional Studies; Echocardiography, Doppler; Female; Hemolysis; Humans; Hypertension, Pulmonary; Male; Risk Factors; Tricuspid Valve Insufficiency | 2013 |
A synthetic receptor for asymmetric dimethyl arginine.
Topics: Arginine; Chromatography, High Pressure Liquid; Combinatorial Chemistry Techniques; Crystallography, X-Ray; Magnetic Resonance Spectroscopy; Methylation; Models, Molecular; Protein Binding; Protein Processing, Post-Translational; Receptors, Drug; Small Molecule Libraries | 2013 |
Influence of ezetimibe on ADMA-DDAH-NO pathway in rat liver subjected to partial ischemia followed by global reperfusion.
Topics: Amidohydrolases; Animals; Anticholesteremic Agents; Arginine; Azetidines; Ezetimibe; Liver; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reperfusion Injury; RNA, Messenger; Time Factors | 2013 |
Effect of cyclophosphamide and morin-5'-sulfonic acid sodium salt, alone or in combination, on ADMA/DDAH pathway in rats.
Topics: Amidohydrolases; Animals; Antioxidants; Arginine; Cyclophosphamide; Drug Therapy, Combination; Female; Flavonoids; Immunosuppressive Agents; Liver; Male; Rats; Rats, Wistar; Sulfonic Acids | 2013 |
Asymmetric dimethylarginine predicts decline of glucose tolerance in men with stable coronary artery disease: a 4.5-year follow-up study.
Topics: Adult; Aged; Angina, Stable; Arginine; Diabetes Mellitus, Type 2; Follow-Up Studies; Glucose Intolerance; Glucose Tolerance Test; Humans; Male; Middle Aged; Prediabetic State; Prognosis; Proportional Hazards Models; Risk Factors | 2013 |
Up-regulation of protein tyrosine nitration in methamphetamine-induced neurotoxicity through DDAH/ADMA/NOS pathway.
Topics: Amidohydrolases; Animals; Arginine; Base Sequence; Brain; DNA Primers; Male; Methamphetamine; Nitrates; Nitric Oxide Synthase; PC12 Cells; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine; Up-Regulation | 2013 |
Impact of high salt independent of blood pressure on PRMT/ADMA/DDAH pathway in the aorta of Dahl salt-sensitive rats.
Topics: Amidohydrolases; Animals; Antihypertensive Agents; Aorta; Arginine; Blood Pressure; Hydralazine; Hypertension; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Protein-Arginine N-Methyltransferases; Rats; Rats, Inbred Dahl; RNA, Messenger; Signal Transduction; Sodium Chloride, Dietary | 2013 |
Asymmetric dimethylarginine predicts survival in the elderly.
Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Cardiovascular Diseases; Cause of Death; Chromatography, Liquid; Female; Follow-Up Studies; Humans; Italy; Male; Population Surveillance; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Factors; Tandem Mass Spectrometry; Time Factors | 2013 |
Monitorization of asymmetric dimethylarginine (ADMA) levels in an experimental ischemia-reperfusion flap model: a preliminary report.
Topics: Abdominal Muscles; Animals; Arginine; Disease Models, Animal; Graft Rejection; Graft Survival; Male; Monitoring, Physiologic; Nitric Oxide; Nitric Oxide Synthase; Postoperative Period; Preoperative Period; Random Allocation; Rats; Rats, Wistar; Reference Values; Reperfusion Injury; Risk Factors; Skin Transplantation; Statistics, Nonparametric; Surgical Flaps | 2013 |
Sex differences of oxidative stress to cholestatic liver and kidney injury in young rats.
Topics: Animals; Arginine; Cationic Amino Acid Transporter 1; Cationic Amino Acid Transporter 2; Cholestasis; Female; Kidney; Liver; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sex Characteristics | 2013 |
Endothelial dysfunction, inflammation and malnutrition markers as predictors of mortality in dialysis patients: multimarker approach.
Topics: Adult; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Inflammation; Kaplan-Meier Estimate; Kidney Failure, Chronic; Male; Malnutrition; Middle Aged; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Renal Dialysis; Risk Assessment; ROC Curve; Serum Albumin; Serum Amyloid A Protein | 2013 |
The usefulness of plasma asymmetric dimethylarginine (ADMA) levels and tissue doppler echocardiography for heart function in term infants born to mothers with gestational diabetes mellitus.
Topics: Arginine; Case-Control Studies; Diabetes, Gestational; Echocardiography, Doppler; Female; Heart; Humans; Infant, Newborn; Male; Mothers; Predictive Value of Tests; Pregnancy; Term Birth; Ventricular Function, Left | 2013 |
Nonstenotic bicuspid aortic valve is associated with elevated plasma asymmetric dimethylarginine.
Topics: Adult; Aorta; Aortic Aneurysm; Aortic Valve; Arginine; Bicuspid Aortic Valve Disease; Biomarkers; Case-Control Studies; Dilatation, Pathologic; Female; Heart Valve Diseases; Homocysteine; Humans; Linear Models; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Multivariate Analysis; Prognosis; Risk Factors; Up-Regulation; Vascular Stiffness; Young Adult | 2013 |
Involvement of DDAH/ADMA pathway in the pathogenesis of rheumatoid arthritis in rats.
Topics: Amidohydrolases; Animals; Ankle Joint; Arginine; Arthritis, Experimental; Arthritis, Rheumatoid; Cytokines; Male; Neuropeptides; Rats; Rats, Sprague-Dawley; Synovial Membrane | 2013 |
Asymmetric dimethylarginine and asthma: results from the Childhood Asthma Prevention Study.
Topics: Arginine; Asthma; Australia; Child; Cohort Studies; Cross-Sectional Studies; Female; Humans; Inflammation; Male; Randomized Controlled Trials as Topic; Respiratory Function Tests; Risk Factors | 2013 |
Effects of losartan and pentoxifylline on renal dimethylarginine dimethylaminohydrolase-1 expression in proteinuric nephropathy.
Topics: Acetylglucosaminidase; Albuminuria; Amidohydrolases; Angiotensin II Type 1 Receptor Blockers; Animals; Arginine; Cell Line; Free Radical Scavengers; Kidney Tubules, Proximal; Losartan; Oxidative Stress; Pentoxifylline; Rats; Reactive Oxygen Species | 2013 |
Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia.
Topics: Amidohydrolases; Animals; Arginine; Blood Vessels; Cyclic GMP; Gene Expression; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Lung; Mice; Nitric Oxide; Nitroarginine; Organ Culture Techniques; Oxadiazoles; Signal Transduction; Vasoconstriction | 2013 |
Elevated circulating levels and tissue expression of pentraxin 3 in uremia: a reflection of endothelial dysfunction.
Topics: Adult; Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Endothelium; Female; Gene Expression; Humans; Kidney; Male; Middle Aged; Prognosis; Renal Insufficiency, Chronic; RNA, Messenger; Serum Amyloid P-Component; Subcutaneous Fat, Abdominal; Uremia; Vascular Resistance | 2013 |
High plasma concentrations of asymmetric dimethylarginine inhibit ischemic cardioprotection in hypercholesterolemic rats.
Topics: Animals; Arginine; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Hypercholesterolemia; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Rats; Rats, Wistar | 2013 |
Increased symmetrical dimethylarginine in ischemic acute kidney injury as a causative factor of renal L-arginine deficiency.
Topics: Acute Kidney Injury; Amidohydrolases; Animals; Arginine; Blotting, Western; Chromatography, High Pressure Liquid; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Intracellular Signaling Peptides and Proteins; Kidney; Kidney Function Tests; Protein-Arginine N-Methyltransferases; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Tandem Mass Spectrometry | 2013 |
Elevated levels of asymmetric dimethylarginine are associated with lower CD4+ count and higher viral load in HIV-infected individuals.
Topics: Adult; Arginine; Biomarkers; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Endothelium, Vascular; Female; HIV Infections; Humans; Hypertension; Male; Middle Aged; Multivariate Analysis; Nitric Oxide; Predictive Value of Tests; Risk Factors; Viral Load | 2013 |
4-HNE increases intracellular ADMA levels in cultured HUVECs: evidence for miR-21-dependent mechanisms.
Topics: Aldehydes; Amidohydrolases; Arginine; Base Sequence; Blotting, Western; Cells, Cultured; DNA Primers; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Humans; MicroRNAs; Real-Time Polymerase Chain Reaction; RNA, Messenger | 2013 |
A comparison of maternal serum levels of endothelial nitric oxide synthase, asymmetric dimethylarginine, and homocysteine in normal and preeclamptic pregnancies.
Topics: Adult; Arginine; Case-Control Studies; Female; Homocysteine; Humans; Nitric Oxide Synthase Type III; Pre-Eclampsia; Pregnancy | 2013 |
Carotid intima-media thickness and plasma asymmetric dimethylarginine in Mexican children exposed to inorganic arsenic.
Topics: Adolescent; Arginine; Arsenic; Atherosclerosis; Biomarkers; Carotid Intima-Media Thickness; Child; Child, Preschool; Cross-Sectional Studies; Environmental Exposure; Enzyme-Linked Immunosorbent Assay; Humans; Linear Models; Mexico; Tunica Intima; Tunica Media; Vascular Cell Adhesion Molecule-1 | 2013 |
Involvement of advanced glycation end product-induced asymmetric dimethylarginine generation in endothelial dysfunction.
Topics: Aged; Amidohydrolases; Arginine; Atherosclerosis; Cells, Cultured; Diabetic Nephropathies; Endothelial Cells; Female; Glycation End Products, Advanced; Humans; Male; Middle Aged; Nitric Oxide; Reactive Oxygen Species; Vascular Diseases | 2013 |
Reactive metabolites and AGE-RAGE-mediated inflammation in patients following liver transplantation.
Topics: Antioxidants; Arginine; Female; Glycation End Products, Advanced; Humans; Inflammation; Liver Transplantation; Male; Models, Biological; Pyruvaldehyde; Receptor for Advanced Glycation End Products; Receptors, Immunologic | 2013 |
L-arginine metabolism in early-onset and late-onset pre-eclamptic pregnancies.
Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Female; Fetal Blood; Humans; omega-N-Methylarginine; Ornithine; Pre-Eclampsia; Pregnancy; Young Adult | 2013 |
Endothelial function in patients with metabolic syndrome and erectile dysfunction: a question of angiopoietin imbalance?
Topics: Angiopoietin-1; Angiopoietin-2; Angiopoietins; Arginine; Biomarkers; Cross-Sectional Studies; Endothelium, Vascular; Hemodynamics; Humans; Impotence, Vasculogenic; Male; Manometry; Metabolic Syndrome; Middle Aged; Obesity, Abdominal; Penile Erection; Penis; Predictive Value of Tests; Severity of Illness Index; Surveys and Questionnaires; Ultrasonography, Doppler, Duplex | 2013 |
Comparison of transesophageal echocardiographic analysis and circulating biomarker expression profile in calcific aortic valve disease.
Topics: Aged; Aged, 80 and over; alpha-2-HS-Glycoprotein; Aortic Valve; Aortic Valve Stenosis; Arginine; Biomarkers; Calcinosis; Case-Control Studies; Echocardiography, Transesophageal; Female; Humans; Male; Natriuretic Peptide, Brain; Osteopontin; Parathyroid Hormone; Peptide Fragments; Sclerosis; Severity of Illness Index | 2013 |
Effect of metabolic abnormalities on endothelial dysfunction in normotensive offspring of subject with hypertension.
Topics: Adiponectin; Adult; Arginine; Biomarkers; Brachial Artery; Case-Control Studies; Disease Progression; Female; Genetic Predisposition to Disease; Heredity; Humans; Hyperemia; Hyperinsulinism; Hypertension; Insulin; Insulin Resistance; Linear Models; Male; Multivariate Analysis; Pedigree; Phenotype; Risk Factors; Ultrasonography; Vasodilation | 2013 |
Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine.
Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Cardiovascular Diseases; Cells, Cultured; Disease Models, Animal; Endothelium, Vascular; Esomeprazole; Gastroesophageal Reflux; Humans; Lansoprazole; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type III; Proton Pump Inhibitors; Risk Factors; Vasodilation | 2013 |
Abdominal obesity is associated with peripheral artery disease in hemodialysis patients.
Topics: Adiponectin; Ankle Brachial Index; Arginine; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Interleukin-6; Lipid Metabolism; Male; Middle Aged; Obesity, Abdominal; Peripheral Arterial Disease; Renal Dialysis; Risk Factors | 2013 |
Portal vein omentin is increased in patients with liver cirrhosis but is not associated with complications of portal hypertension.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Ascites; Case-Control Studies; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; GPI-Linked Proteins; Humans; Hypertension, Portal; Kidney; Kidney Function Tests; Lectins; Liver; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Portal Vein; Portasystemic Shunt, Surgical; Varicose Veins | 2013 |
Assessment of L-arginine asymmetric 1 dimethyl (ADMA) in early-onset and late-onset (severe) preeclampsia.
Topics: Arginine; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Nitric Oxide; Pre-Eclampsia; Pregnancy | 2013 |
Effect of ethinyl estradiol-cyproterone acetate treatment on asymmetric dimethyl-arginine levels in women with polycystic ovary syndrome.
Topics: Adult; Androgen Antagonists; Arginine; Cholesterol, LDL; Cyproterone Acetate; Drug Combinations; Ethinyl Estradiol; Female; Glucose; Humans; Insulin Resistance; Lipid Metabolism; Polycystic Ovary Syndrome; Prospective Studies; Young Adult | 2014 |
ON NO--the continuing story of nitric oxide, diabetes, and cardiovascular disease.
Topics: Arginine; Diabetes Mellitus, Type 2; Humans; Insulin; Insulin Resistance; Male; Nitric Oxide | 2013 |
Plasma concentrations of arginine and asymmetric dimethylarginine do not reflect their intracellular concentrations in peripheral blood mononuclear cells.
Topics: Arginine; Biomarkers; Homoarginine; Humans; Leukocytes, Mononuclear; Nitric Oxide | 2013 |
Genetic variation in the dimethylarginine dimethylaminohydrolase 1 gene (DDAH1) is related to asymmetric dimethylarginine (ADMA) levels, but not to endothelium-dependent vasodilation.
Topics: Age Factors; Aged; Amidohydrolases; Arginine; Brachial Artery; Chromatography, High Pressure Liquid; Endothelium, Vascular; Female; Genotype; Humans; Isoenzymes; Male; Phenotype; Polymorphism, Single Nucleotide; Prospective Studies; Sweden; Ultrasonography; Vasodilation | 2013 |
Asymmetric dimethylarginine: a disease marker for asthma?
Topics: Arginine; Asthma; Female; Humans; Male | 2013 |
Serum methylarginines and incident depression in a cohort of older adults.
Topics: Aged; Aged, 80 and over; Arginine; Depression; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; New South Wales; Nitric Oxide Synthase | 2013 |
Serum endothelin-1 and NT-proBNP, but not ADMA, endoglin and TIMP-1 levels, reflect impaired right ventricular function in patients with systemic sclerosis.
Topics: Adult; Aged; Antigens, CD; Arginine; Biomarkers; Case-Control Studies; Collagen; Echocardiography; Echocardiography, Doppler; Endoglin; Endothelin-1; Endothelium, Vascular; Female; Fibrosis; Humans; Lung Diseases; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Prospective Studies; Receptors, Cell Surface; Scleroderma, Systemic; Tissue Inhibitor of Metalloproteinase-1; Ventricular Function, Right | 2014 |
Plasma asymmetric dimethylarginine and adverse events in patients with atrial fibrillation referred for coronary angiogram.
Topics: Aged; Aged, 80 and over; Arginine; Atrial Fibrillation; Cardiovascular Diseases; Coronary Angiography; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Multivariate Analysis; Predictive Value of Tests; Proportional Hazards Models; Referral and Consultation; Risk Assessment; Risk Factors; Stroke; Survival Rate; Time Factors | 2013 |
Elevated asymmetric dimethylarginine levels predict short- and long-term mortality risk in critically ill patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Case-Control Studies; Critical Illness; Female; Humans; Intensive Care Units; Male; Middle Aged; Multiple Organ Failure; Predictive Value of Tests; Prognosis; Prospective Studies; Risk Factors; Sepsis; Severity of Illness Index; Survival Rate | 2013 |
Endothelial cell transfusion ameliorates endothelial dysfunction in 5/6 nephrectomized rats.
Topics: Acetylcholine; Amidohydrolases; Animals; Aorta; Arginine; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Male; Mesenteric Arteries; Myography; Nephrectomy; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Vasodilation; Vasodilator Agents | 2013 |
Enhanced levels of asymmetric dimethylarginine in a serum of middle age patients with myelodysplastic syndrome.
Topics: Adult; Arginine; Case-Control Studies; Female; Humans; Male; Middle Aged; Myelodysplastic Syndromes; Oxidative Stress | 2013 |
Association between endothelial dysfunction and frailty: the Toledo Study for Healthy Aging.
Topics: Aged; Arginine; Atherosclerosis; Biomarkers; Comorbidity; Demography; Female; Frail Elderly; Geriatric Assessment; Humans; Longitudinal Studies; Male; Middle Aged; Prospective Studies; Risk Factors; Sex Factors; Spain | 2014 |
Effects of acute and chronic stress on the L-arginine nitric oxide pathway in black and white South Africans: the sympathetic activity and ambulatory blood pressure in Africans study.
Topics: Acute Disease; Adult; Arginine; Black People; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cardiovascular Diseases; Chronic Disease; Cold Temperature; Cross-Sectional Studies; Disease Susceptibility; Female; Hemodynamics; Humans; Male; Middle Aged; Motor Activity; Nitric Oxide; Pressure; Rest; South Africa; Stress, Psychological; Stroop Test; White People | 2013 |
High asymmetric dimethylarginine (ADMA) levels in patients with brucellosis.
Topics: Adult; Arginine; Brucella; Brucellosis; Female; Humans; Male; Nitric Oxide; Nitric Oxide Synthase; ROC Curve; Vasculitis | 2014 |
Apelin-13 deteriorates hypertension in rats after damage of the vascular endothelium by ADMA.
Topics: Animals; Arginine; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Endothelium, Vascular; Hypertension; Injections, Intravenous; Intercellular Signaling Peptides and Proteins; Male; Myosin Light Chains; Nitric Oxide; Phosphorylation; Rats; Rats, Sprague-Dawley; Time Factors; Vasoconstriction; Vasodilation; von Willebrand Factor | 2013 |
Asymmetric dimethylarginine (ADMA) and soluble vascular cell adhesion molecule 1(sVCAM-1) as circulating markers for endothelial dysfunction in patients with pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Arginine; Biomarkers; Blood Glucose; Blood Pressure; Catecholamines; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypertension; Lipids; Male; Middle Aged; Pheochromocytoma; Vascular Cell Adhesion Molecule-1; Vascular Diseases | 2013 |
Symmetrical dimethylarginine predicts mortality in the general population: observations from the Dallas heart study.
Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Female; Follow-Up Studies; Humans; Male; Middle Aged; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Risk Factors; Texas | 2013 |
Urinary NGAL and hematic ADMA levels: an early sign of cardio-renal syndrome in young adults born preterm?
Topics: Acute-Phase Proteins; Adolescent; Adult; Adult Children; Arginine; Cardio-Renal Syndrome; Case-Control Studies; Female; Humans; Infant, Newborn; Infant, Premature; Lipocalin-2; Lipocalins; Male; Pregnancy; Premature Birth; Prognosis; Proto-Oncogene Proteins; Young Adult | 2013 |
Structure and function of large arteries in hypertension in relation to oxidative stress markers.
Topics: Adult; Advanced Oxidation Protein Products; Arginine; Arteries; Biomarkers; Carotid Arteries; Carotid Intima-Media Thickness; Female; Humans; Hypertension; Lipoproteins, LDL; Male; Middle Aged; Multivariate Analysis; Oxidative Stress; Pulse Wave Analysis; Vascular Stiffness | 2013 |
Impaired endothelial function after aneurysmal subarachnoid haemorrhage correlates with arginine:asymmetric dimethylarginine ratio.
Topics: Adult; Arginine; Biomarkers; Blood Flow Velocity; Endothelium; Female; Follow-Up Studies; Humans; Hyperemia; Male; Middle Aged; Prospective Studies; Subarachnoid Hemorrhage; Survival Analysis; Vasospasm, Intracranial | 2014 |
The role of profilin-1 in endothelial cell injury induced by advanced glycation end products (AGEs).
Topics: Antioxidants; Arginine; Cells, Cultured; Cytoskeleton; Dose-Response Relationship, Drug; Glycation End Products, Advanced; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; NF-kappa B; Nitric Oxide; Profilins; Protein Kinase C; Protein Kinase Inhibitors; Reactive Oxygen Species; RNA Interference; RNA, Messenger; Signal Transduction; Time Factors; Transfection | 2013 |
Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway.
Topics: Aged; Antibodies, Monoclonal; Apoptosis; Arginine; Case-Control Studies; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Culture Media, Serum-Free; Doxorubicin; Enzyme Activation; fas Receptor; Female; Fibroblasts; Humans; JNK Mitogen-Activated Protein Kinases; Male; Middle Aged; Signal Transduction; Sphingosine | 2013 |
Simultaneous determination of homocysteine and asymmetric dimethylarginine in human urine by liquid chromatography-tandem mass spectrometry.
Topics: Arginine; Biomarkers; Chromatography, Liquid; Coronary Artery Disease; Homocysteine; Humans; Limit of Detection; Linear Models; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
Gender differences in oxidative and nitrosative stress parameters in kidney transplant patients on tacrolimus-based immunosuppression.
Topics: Adult; Advanced Oxidation Protein Products; Arginine; Catalase; Female; Healthy Volunteers; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Mycophenolic Acid; Nitrates; Nitrites; Oxidative Stress; Prednisone; Sex Factors; Sulfhydryl Compounds; Tacrolimus; Thiobarbituric Acid Reactive Substances | 2014 |
Differential associations of angiographic extent and severity of coronary artery disease with asymmetric dimethylarginine but not insulin resistance in non-diabetic men with stable angina: a cross-sectional study.
Topics: Adult; Aged; Angina, Stable; Arginine; Biomarkers; Blood Glucose; Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studies; Humans; Insulin; Insulin Resistance; Linear Models; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Risk Factors; Severity of Illness Index | 2013 |
Asymmetric dimethylarginine accumulates in the kidney during ischemia/reperfusion injury.
Topics: Acetylcysteine; Amidohydrolases; Animals; Arginine; Kidney; Male; Mice, Inbred C57BL; Nitric Oxide Synthase Type III; Oxidative Stress; Reperfusion Injury | 2014 |
Soluble TWEAK plasma levels increase after renal transplantation and associate with the improvement of endothelial function.
Topics: Adult; Arginine; Biomarkers; Brachial Artery; C-Reactive Protein; Cytokine TWEAK; Endothelium, Vascular; Female; Humans; Kidney Transplantation; Male; Postoperative Period; Prospective Studies; Renal Insufficiency, Chronic; Tumor Necrosis Factors; Vascular Diseases; Vasodilation | 2013 |
Two different approaches to restore renal nitric oxide and prevent hypertension in young spontaneously hypertensive rats: l-citrulline and nitrate.
Topics: Animals; Arginine; Citrulline; Dietary Supplements; Hypertension; Male; Nitrates; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2014 |
Determination of homoarginine, arginine, NMMA, ADMA, and SDMA in biological samples by HPLC-ESI-mass spectrometry.
Topics: Arginine; Chromatography, High Pressure Liquid; Homoarginine; Humans; Tandem Mass Spectrometry | 2013 |
A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with chronic kidney disease.
Topics: Adult; Aged; Alleles; Amidohydrolases; Arginine; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Renal Insufficiency, Chronic; White People | 2013 |
Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury.
Topics: Acute Lung Injury; Amidohydrolases; Animals; Arginine; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Genetic Therapy; Humans; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Microvessels; Oxidative Stress; Peroxynitrous Acid; Pulmonary Edema; Superoxides; Time Factors; Transfection; Up-Regulation | 2014 |
The cardiovascular risk marker asymmetric dimethylarginine is elevated in asymptomatic, untreated HIV-1 infection and correlates with markers of immune activation and disease progression.
Topics: Adenosine Deaminase; Adult; Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; Cross-Sectional Studies; Female; HIV Infections; HIV Seropositivity; Humans; Immunoglobulin G; Interleukin-6; Male; Viral Load | 2014 |
Memory impairment is associated with serum methylarginines in older adults.
Topics: Aged; Aged, 80 and over; Arginine; Atrial Fibrillation; Cohort Studies; Diabetes Mellitus; Educational Status; Female; Humans; Logistic Models; Male; Memory Disorders; Middle Aged; Multivariate Analysis; Neuropsychological Tests; Odds Ratio; Severity of Illness Index | 2014 |
Increased serum asymmetric dimethylarginine level is an independent predictor of contrast-induced nephropathy.
Topics: Aged; Angina Pectoris; Arginine; Contrast Media; Coronary Angiography; Creatinine; Female; Humans; Kidney Diseases; Male; Middle Aged; Predictive Value of Tests; ROC Curve | 2013 |
Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes.
Topics: Aged; Arginine; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Environment; Female; Genotype; Humans; Intermittent Claudication; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors | 2014 |
Effect of therapeutic inhibition of TNF on circulating endothelial progenitor cells in patients with rheumatoid arthritis.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antigens, CD34; Arginine; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Etanercept; Female; Flow Cytometry; Humans; Immunoglobulin G; Inflammation; Leukocytes, Mononuclear; Male; Middle Aged; Receptors, Tumor Necrosis Factor; Stem Cells; Tumor Necrosis Factor-alpha; Ultrasonography, Doppler; Vascular Endothelial Growth Factor Receptor-2 | 2013 |
Severe pulmonary embolism decreases plasma L-arginine.
Topics: Arginase; Arginine; Chromatography, High Pressure Liquid; Echocardiography, Doppler; Hemolysis; Humans; Hypertension, Pulmonary; Prospective Studies; Pulmonary Embolism; Tricuspid Valve; Tricuspid Valve Insufficiency | 2014 |
Renoprotective effects of melatonin in young spontaneously hypertensive rats with L-NAME.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amidohydrolases; Animals; Antioxidants; Arginine; Blood Pressure; Deoxyguanosine; Humans; Hypertension; Hypertension, Renal; Kidney; Male; Melatonin; Nephritis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR | 2014 |
L-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in plasma and synovial fluid of patients with knee osteoarthritis.
Topics: Arginine; Case-Control Studies; Humans; Nitric Oxide; Osteoarthritis, Knee; Signal Transduction; Synovial Fluid; Thiobarbituric Acid Reactive Substances | 2013 |
Markers of endothelial dysfunction and evaluation of vascular reactivity tests in Behçet disease.
Topics: Adult; Arginine; Behcet Syndrome; Biomarkers; Blood Sedimentation; Case-Control Studies; Endothelium, Vascular; Female; Homocysteine; Humans; Lipids; Male; Middle Aged; Prospective Studies; Ultrasonography; Vasodilation | 2014 |
Lipoprotein apheresis reduces biomarkers of plaque destabilization and cardiovascular risk.
Topics: Adult; Aged; Arginine; Biomarkers; Blood Component Removal; C-Reactive Protein; Cardiovascular Diseases; Female; Humans; Lipoproteins; Male; Matrix Metalloproteinase 9; Middle Aged; Plaque, Atherosclerotic; Pregnancy-Associated Plasma Protein-A; Vascular Cell Adhesion Molecule-1 | 2014 |
Modulation of arginine and asymmetric dimethylarginine concentrations in liver and plasma by exogenous hydrogen sulfide in LPS-induced endotoxemia.
Topics: Alanine Transaminase; Amidohydrolases; Animals; Arginase; Arginine; Aspartate Aminotransferases; Endotoxemia; Hydrogen Sulfide; Hypoxia-Inducible Factor 1, alpha Subunit; Lipopolysaccharides; Liver; Male; Peroxidase; Rats; Rats, Wistar | 2013 |
Asymmetric dimethylarginine and augmentation index in newly diagnosed patients with hypertension.
Topics: Adult; Age Factors; Alcohol Drinking; Aorta; Arginine; Arterial Pressure; Biomarkers; C-Reactive Protein; Female; Humans; Hypertension; Inflammation Mediators; Male; Middle Aged; Predictive Value of Tests; Pulse Wave Analysis; Risk Factors; Sex Factors; Smoking; Vascular Stiffness | 2015 |
Asymmetric dimethylarginine blocks nitric oxide-mediated alcohol-stimulated cilia beating.
Topics: Amidohydrolases; Animals; Arginine; Bronchi; Cattle; Cell Survival; Cells, Cultured; Cilia; Cyclic AMP-Dependent Protein Kinases; Epithelial Cells; Ethanol; Lung; Lung Diseases; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Time Factors; Trachea | 2013 |
Relationship between serum paraoxonase and homocysteine thiolactonase activity, adipokines, and asymmetric dimethyl arginine concentrations in renal transplant patients.
Topics: Adipokines; Adult; Aged; Arginine; Aryldialkylphosphatase; Atherosclerosis; Biomarkers; C-Reactive Protein; Carboxylic Ester Hydrolases; Case-Control Studies; Colorimetry; Enzyme-Linked Immunosorbent Assay; Female; Humans; Kidney Transplantation; Lipids; Male; Middle Aged; Predictive Value of Tests; Renal Dialysis; Renal Insufficiency; Risk Factors; Spectrophotometry; Treatment Outcome | 2013 |
Clinical metabolomics and hematic ADMA predict the future onset of cardiorenal syndrome in young grown-up subjects who were born preterm.
Topics: Adult; Arginine; Cardio-Renal Syndrome; Case-Control Studies; Discriminant Analysis; Female; Gestational Age; Humans; Infant, Extremely Low Birth Weight; Infant, Newborn; Least-Squares Analysis; Male; Metabolomics; Premature Birth; Young Adult | 2014 |
Predictive value of plasma asymmetric dimethylarginine, homocysteine, and high-sensitive CRP levels in occult coronary artery disease: A multidetector-row computed tomography study.
Topics: Arginine; Biomarkers; C-Reactive Protein; Coronary Artery Disease; Female; Homocysteine; Humans; Male; Middle Aged; Multidetector Computed Tomography; Prognosis; Reproducibility of Results; Risk Assessment; Sensitivity and Specificity | 2015 |
Platelet content of nitric oxide synthase 3 phosphorylated at Serine 1177 is associated with the functional response of platelets to aspirin.
Topics: Aged; Arginine; Aspirin; Blood Platelets; Blotting, Western; Collagen; Erythrocytes; Female; Flow Cytometry; Humans; Leukocytes; Light; Male; Mutation; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Phosphorylation; Phosphoserine | 2013 |
Asymmetric dimethylarginine is related to the predicted stroke risk in middle-aged Japanese men.
Topics: Adult; Aged; Arginine; Humans; Linear Models; Male; Middle Aged; Retrospective Studies; Risk Factors; Stroke; Surveys and Questionnaires; Young Adult | 2014 |
ADMA levels and arginine/ADMA ratios reflect severity of disease and extent of inflammation after subarachnoid hemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; C-Reactive Protein; Cytokines; Female; Humans; Inflammation; Male; Middle Aged; Severity of Illness Index; Subarachnoid Hemorrhage | 2014 |
[Effect of crucumin on vascular endothelial function in atherosclerotic rabbits].
Topics: Animals; Arginine; Atherosclerosis; Curcumin; Endothelium, Vascular; Male; Nitric Oxide Synthase; Rabbits | 2013 |
I. Peripheral endothelial dysfunction after subarachnoid haemorrhage: what the fingertips can tell us.
Topics: Arginine; Endothelium; Female; Humans; Male; Subarachnoid Hemorrhage | 2014 |
Asymmetric dimethylarginine is not associated with subendocardial viability ratio in Rheumatoid Arthritis.
Topics: Aged; Arginine; Arthritis, Rheumatoid; Cardiovascular Diseases; Endocardium; Female; Humans; Male; Middle Aged; Risk Assessment | 2014 |
The effects of acute intermittent hypoxia on cardiovascular parameters in normotensive and chronic hypobaric hypoxia-induced hypertensive rabbits.
Topics: Air Pressure; Animals; Arginine; Blood Pressure; Cardiovascular System; Endothelin-1; Hematocrit; Hypertension; Nitric Oxide Synthase Type III; Norepinephrine; Oxygen; Rabbits; Time Factors | 2014 |
The inhibitory effect of quercetin on asymmetric dimethylarginine-induced apoptosis is mediated by the endoplasmic reticulum stress pathway in glomerular endothelial cells.
Topics: Apoptosis; Arginine; Cells, Cultured; eIF-2 Kinase; Endoplasmic Reticulum Stress; Endoribonucleases; Endothelial Cells; Humans; JNK Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Quercetin; RNA Interference; RNA, Small Interfering; Signal Transduction; Transcription Factor CHOP; Transforming Growth Factor beta | 2014 |
N-acetylcysteine prevents hypertension via regulation of the ADMA-DDAH pathway in young spontaneously hypertensive rats.
Topics: Acetylcysteine; Amidohydrolases; Animals; Arginine; Blood Pressure; Glutathione; Humans; Hypertension; Metabolic Networks and Pathways; Nitric Oxide; Oxidative Stress; Rats; Superoxides | 2013 |
The asymmetric dimethylarginine level is associated with the predicted stroke risk in Japanese women.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Japan; Middle Aged; Odds Ratio; Prognosis; Risk Factors; Stroke | 2014 |
Asymmetric dimethyl L-arginine, nitric oxide and cardiovascular disease in adolescent type 1 diabetics.
Topics: Adolescent; Arginine; Brachial Artery; Cardiovascular Diseases; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Egypt; Electrocardiography; Female; Humans; Lipids; Male; Nitric Oxide; Ultrasonography | 2014 |
Increased levels of asymmetric dimethylarginine are associated with pulmonary arterial hypertension in HIV infection.
Topics: Adult; Arginine; Biomarkers; Blood Pressure; Catheterization, Swan-Ganz; Cohort Studies; Echocardiography; Familial Primary Pulmonary Hypertension; Female; HIV Infections; Humans; Hypertension, Pulmonary; Male; Middle Aged; Prospective Studies | 2014 |
Ligand-dependent dynamics of the active-site lid in bacterial dimethylarginine dimethylaminohydrolase.
Topics: Amidohydrolases; Arginine; Catalytic Domain; Citrulline; Kinetics; Ligands; Molecular Dynamics Simulation; Nuclear Magnetic Resonance, Biomolecular; Pseudomonas aeruginosa | 2014 |
Other factors ought to be kept in mind when analyzing plasma asymmetric dimethylarginine levels.
Topics: Arginine; Carotid Arteries; Exercise; Female; Humans; Postmenopause; Vascular Stiffness | 2014 |
Response to "Other factors ought to be kept in mind when analyzing plasma asymmetric dimethylarginine levels".
Topics: Arginine; Carotid Arteries; Exercise; Female; Humans; Postmenopause; Vascular Stiffness | 2014 |
Advanced intrauterine growth restriction is associated with reduced excretion of asymmetric dimethylarginine.
Topics: Adolescent; Adult; Arginine; Case-Control Studies; Female; Fetal Growth Retardation; Humans; Infant, Extremely Low Birth Weight; Infant, Newborn; Male | 2014 |
Asymmetric dimethylarginine and oxidative stress following coronary artery bypass grafting: associations with postoperative outcome.
Topics: Aged; Arginine; Coronary Artery Bypass; Dinoprost; Female; Hospital Mortality; Humans; Male; Middle Aged; Myocardial Infarction; Oxidative Stress; Postoperative Complications | 2014 |
Association of asymmetric dimethylarginine levels with treadmill-stress-test-derived prognosticators.
Topics: Aged; Arginine; Biomarkers; Coronary Artery Disease; Exercise Test; Female; Humans; Male; Middle Aged; Prognosis; Risk Factors | 2014 |
Assessment of inflammatory biomarkers and oxidative stress in pulmonary thromboembolism: follow-up results.
Topics: Adult; Aged; Antioxidants; Arginine; Case-Control Studies; Female; Follow-Up Studies; Humans; Hypoxia; Inflammation; Interleukin-6; Male; Middle Aged; Oxidative Stress; Prospective Studies; Pulmonary Embolism; Risk Factors; Tumor Necrosis Factor-alpha | 2014 |
Determination of asymmetric Nα-acetyldimethylarginine in humans: a phase II metabolite of asymmetric dimethylarginine.
Topics: Acetylation; Adult; Arginine; Blood Chemical Analysis; Calibration; Female; Humans; Male; Middle Aged; Reference Standards; Reproducibility of Results; Urinalysis; Young Adult | 2014 |
Elevated asymmetric dimethylarginine is associated with oxidant stress aggravation in patients with early stage autosomal dominant polycystic kidney disease.
Topics: Adolescent; Adult; Aged; Arginine; Dinoprost; Disease Progression; Female; Glomerular Filtration Rate; Humans; Isoprostanes; Kidney Function Tests; Lipoproteins, LDL; Male; Middle Aged; Oxidative Stress; Polycystic Kidney, Autosomal Dominant; Young Adult | 2013 |
Determination of oxidative stress and cellular inflammation in patients with diabetic nephropathy and non-diabetic nephropathy being administered hemodialysis treatment due to chronic renal failure.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Arginine; Biomarkers; C-Reactive Protein; Case-Control Studies; Deoxyguanosine; Diabetic Nephropathies; Female; Humans; Inflammation; Interleukin-6; Kidney Failure, Chronic; Male; Malondialdehyde; Middle Aged; Neopterin; Oxidative Stress; Tumor Necrosis Factor-alpha | 2014 |
An assessment of correlation between serum asymmetric dimethylarginine and glycated haemoglobin in patients with type 2 diabetes mellitus.
Topics: Arginine; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Female; Glycated Hemoglobin; Humans; Hyperglycemia; Male; Middle Aged; Nephelometry and Turbidimetry; Oxidative Stress | 2014 |
The relation of maternal serum eNOS, NOSTRIN and ADMA levels with aetiopathogenesis of preeclampsia and/or intrauterine fetal growth restriction.
Topics: Adaptor Proteins, Signal Transducing; Adult; Arginine; Case-Control Studies; DNA-Binding Proteins; Female; Fetal Growth Retardation; Humans; Intracellular Signaling Peptides and Proteins; Nitric Oxide Synthase Type III; Pre-Eclampsia; Pregnancy; Young Adult | 2015 |
Reduced sTWEAK and increased sCD163 levels in HIV-infected patients: modulation by antiretroviral treatment, HIV replication and HCV co-infection.
Topics: Adult; Anti-Retroviral Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Arginine; C-Reactive Protein; Case-Control Studies; Coinfection; Cytokine TWEAK; Female; Hepacivirus; Hepatitis C; HIV; HIV Infections; Humans; Interleukin-6; Male; Middle Aged; Receptors, Cell Surface; Tumor Necrosis Factors; Vascular Cell Adhesion Molecule-1; Young Adult | 2014 |
Asymmetric dimethylarginine responses during interferon-α-induced depression in patients with chronic hepatitis C infection.
Topics: Adult; Analysis of Variance; Antiviral Agents; Arginine; Cardiovascular Diseases; Chromatography, Liquid; Depression; Depressive Disorder; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Nitric Oxide Synthase; Prospective Studies; Psychiatric Status Rating Scales; Regression Analysis; Ribavirin; Risk Factors; Time Factors | 2014 |
Pharmacological inhibition of DDAH1 improves survival, haemodynamics and organ function in experimental septic shock.
Topics: Amidohydrolases; Animals; Arginine; Endotoxemia; Enzyme Inhibitors; Fluid Therapy; Hemodynamics; Macrophages, Peritoneal; Male; Norepinephrine; Peritonitis; Rats; Rats, Wistar; Shock, Septic | 2014 |
Evaluation of asymmetric dimethylarginine (ADMA) levels in children with growth hormone deficiency.
Topics: Adolescent; Arginine; Biomarkers; Blood Glucose; Case-Control Studies; Child; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Growth Disorders; Human Growth Hormone; Humans; Insulin; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Male; Prognosis | 2014 |
Exogenous asymmetric dimethylarginine (ADMA) in pathogenesis of ischemia-reperfusion-induced gastric lesions: interaction with protective nitric oxide (NO) and calcitonin gene-related peptide (CGRP).
Topics: Animals; Arginine; Blood Flow Velocity; Calcitonin Gene-Related Peptide; Capsaicin; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Gastric Mucosa; Interleukin-10; Isoxazoles; Male; Malondialdehyde; Nitric Oxide; Rats, Wistar; Reperfusion Injury; Stomach Diseases; Tumor Necrosis Factor-alpha | 2014 |
Endogenous nitric-oxide synthase inhibitor ADMA after acute brain injury.
Topics: Amidohydrolases; Animals; Arginine; Brain Injuries; Immunohistochemistry; Male; Motor Activity; Nitric Oxide; Nitric Oxide Synthase; Protein-Arginine N-Methyltransferases; Rats, Sprague-Dawley; Time Factors | 2014 |
Widespread endotheliopathy in adults with cyanotic congenital heart disease.
Topics: Adult; Arginine; Brachial Artery; Case-Control Studies; Cell Count; Cyanosis; Endothelial Cells; Endothelial Progenitor Cells; Endothelin-1; Female; Flow Cytometry; Heart Defects, Congenital; Humans; Male; Middle Aged; Nitric Oxide; Retinal Artery; Retinal Vein; Risk Factors | 2015 |
Asymmetric dimethylarginine levels in patients with cutaneous anthrax: a laboratory analysis.
Topics: Adolescent; Adult; Aged; Anthrax; Arginine; Biomarkers; Female; Germany; Humans; Male; Middle Aged; Skin Diseases, Bacterial; Young Adult | 2014 |
Effects of eicosapentaenoic acid on the levels of inflammatory markers, cardiac function and long-term prognosis in chronic heart failure patients with dyslipidemia.
Topics: Aged; Arginine; Biomarkers; Chemokine CCL2; Chromatography, High Pressure Liquid; Chronic Disease; Dyslipidemias; Eicosapentaenoic Acid; Female; Follow-Up Studies; Heart Failure; Humans; Inflammation Mediators; Male; Prognosis; Survival Rate; Ventricular Function, Left | 2014 |
Effect of lowering asymmetric dimethylarginine (ADMA) on vascular pathology in atherosclerotic ApoE-deficient mice with reduced renal mass.
Topics: Amidohydrolases; Animals; Aorta; Apolipoproteins E; Arginine; Atherosclerosis; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nephrectomy; Nitric Oxide Synthase; Plaque, Atherosclerotic; Renal Insufficiency, Chronic; Transaminases | 2014 |
Relationship between c-reactive protein and the asymmetric dimethylarginine-induced endothelial dysfunction pathway in vasospastic angina.
Topics: Aged; Angina, Unstable; Arginine; Biomarkers; Brachial Artery; C-Reactive Protein; Coronary Angiography; Coronary Vasospasm; Endothelium, Vascular; Female; Humans; Hyperventilation; Lipoproteins, LDL; Logistic Models; Male; Middle Aged; Risk Factors; Smoking; Tomography, X-Ray Computed; Vasodilation | 2014 |
Structural determinants for the strict monomethylation activity by trypanosoma brucei protein arginine methyltransferase 7.
Topics: Amino Acid Sequence; Arginine; Catalytic Domain; Crystallography, X-Ray; Guanidine; Histones; Methylation; Models, Molecular; Molecular Sequence Data; Protein Multimerization; Protein-Arginine N-Methyltransferases; Protozoan Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Trypanosoma brucei brucei | 2014 |
Asymmetric dimethylarginine in chronic obstructive pulmonary disease (ADMA in COPD).
Topics: Aged; Arginase; Arginine; Chromatography, High Pressure Liquid; Female; Forced Expiratory Volume; Humans; Lung; Male; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Pulmonary Disease, Chronic Obstructive; Sputum; Tandem Mass Spectrometry | 2014 |
ADMA/SDMA in elderly subjects with asymptomatic carotid atherosclerosis: values and site-specific association.
Topics: Aged; Aged, 80 and over; Arginine; C-Reactive Protein; Carotid Arteries; Carotid Artery Diseases; Carotid Intima-Media Thickness; Cholesterol; Cholesterol, LDL; Female; Humans; Male; Middle Aged; Triglycerides | 2014 |
Interactions between inflammatory activation and endothelial dysfunction selectively modulate valve disease progression in patients with bicuspid aortic valve.
Topics: Aorta; Aortic Valve; Arginine; Bicuspid Aortic Valve Disease; Biomarkers; Disease Progression; Echocardiography; Endothelium, Vascular; Female; Follow-Up Studies; Heart Valve Diseases; Humans; Inflammation; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Nitric Oxide Synthase; Peroxidase; Prognosis; Retrospective Studies; Severity of Illness Index; Vasodilation | 2014 |
Asymmetric dimethylarginine levels in children with β-thalassemia and their correlations to tricuspid regurgitant jet velocity.
Topics: Adolescent; Arginine; beta-Thalassemia; Case-Control Studies; Child; Echocardiography, Doppler; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Male; Prognosis; Risk Factors; Tricuspid Valve Insufficiency | 2014 |
[Effects of continuous positive airway pressure treatment of inflammatory factors in patients with overlap syndrome].
Topics: Adult; Aged; Arginine; C-Reactive Protein; Continuous Positive Airway Pressure; Female; Humans; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Sleep Apnea, Obstructive; Tumor Necrosis Factor-alpha | 2014 |
The effects of Ramadan fasting on endothelial function in patients with cardiovascular diseases.
Topics: Adult; Arginine; Cardiovascular Diseases; Cerebrovascular Disorders; Coronary Artery Disease; Endothelium, Vascular; Fasting; Humans; Islam; Male; Malondialdehyde; Middle Aged; Nitric Oxide; Peripheral Arterial Disease; Vascular Endothelial Growth Factor A | 2014 |
L-arginine/NO pathway is altered in children with haemolytic-uraemic syndrome (HUS).
Topics: Arginine; Case-Control Studies; Child; Child, Preschool; Female; Hemoglobins; Hemolytic-Uremic Syndrome; Hospitalization; Humans; Male; Nitrates; Nitric Oxide; Nitrites; Peritoneal Dialysis; Signal Transduction | 2014 |
Regulation of endothelial progenitor cell differentiation and function by dimethylarginine dimethylaminohydrolase 2 in an asymmetric dimethylarginine-independent manner.
Topics: Amidohydrolases; Arginine; Cell Differentiation; Cells, Cultured; Cellular Senescence; Endothelial Progenitor Cells; Humans; RNA Interference; RNA, Messenger; RNA, Small Interfering; Sirtuin 1; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2014 |
Asymmetric dimethylarginine does not inhibit arginase activity and is pro-proliferative in pulmonary endothelial cells.
Topics: Animals; Arginase; Arginine; Cattle; Cell Proliferation; Endothelial Cells; Lung; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Substrate Specificity; Urea | 2014 |
Relation of asymmetric dimethylarginine levels to macrovascular disease and inflammation markers in type 2 diabetic patients.
Topics: Aged; Arginine; Atherosclerosis; Biomarkers; Blood Sedimentation; C-Reactive Protein; Carotid Intima-Media Thickness; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Fibrinogen; Homocysteine; Humans; Inflammation Mediators; Male; Middle Aged; Regression Analysis; Systemic Vasculitis; Up-Regulation | 2014 |
Increased cerebrospinal fluid concentrations of asymmetric dimethylarginine correlate with adverse clinical outcome in subarachnoid hemorrhage patients.
Topics: Adult; Aged; Arginine; Chromatography, High Pressure Liquid; Disease Progression; Female; Follow-Up Studies; Humans; Logistic Models; Male; Middle Aged; Prognosis; Severity of Illness Index; Spinal Puncture; Subarachnoid Hemorrhage; Time Factors; Ultrasonography, Doppler, Transcranial; Vasospasm, Intracranial | 2014 |
Incidence of all-cause and cardiovascular mortality predicted by symmetric dimethylarginine in the population-based study of health in pomerania.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Cardiovascular Diseases; Female; Humans; Incidence; Male; Middle Aged; Young Adult | 2014 |
Plasma ADMA concentrations associate with aerobic fitness in postmenopausal women.
Topics: Aged; Arginine; Exercise; Female; Humans; Middle Aged; Oxygen Consumption; Physical Fitness; Postmenopause | 2014 |
Aliskiren in early postnatal life prevents hypertension and reduces asymmetric dimethylarginine in offspring exposed to maternal caloric restriction.
Topics: Amides; Angiotensin-Converting Enzyme 2; Animals; Animals, Newborn; Arginine; Blood Pressure; Blotting, Western; Body Weight; Caloric Restriction; Female; Fumarates; Gene Expression Regulation; Histone Deacetylases; Hypertension; Losartan; Male; Peptidyl-Dipeptidase A; Rats, Sprague-Dawley | 2015 |
Does asymmetric dimethylarginine (ADMA) plasma concentration predict esophageal varices in patients with cirrhosis?
Topics: Aged; Arginine; Biomarkers; Esophageal and Gastric Varices; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Predictive Value of Tests | 2014 |
Asymmetric dimethylarginine and whole blood viscosity in renal failure.
Topics: Adult; Arginine; Blood Viscosity; Female; Humans; Kidney Failure, Chronic; Male; Risk Factors; Young Adult | 2015 |
Resting brain perfusion and selected vascular risk factors in healthy elderly subjects.
Topics: Aged; Arginine; Brain; Caffeine; Cerebrovascular Circulation; Female; Hematocrit; Homocysteine; Humans; Male; Middle Aged; Risk Factors | 2014 |
Differential associations of inflammatory and endothelial biomarkers with disease activity in rheumatoid arthritis of short duration.
Topics: Adult; Arginine; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; E-Selectin; Female; Humans; Interleukin-6; Male; Middle Aged; Osteoprotegerin; Risk Factors; Serum Amyloid P-Component; Vascular Cell Adhesion Molecule-1; von Willebrand Factor | 2014 |
Melatonin therapy prevents programmed hypertension and nitric oxide deficiency in offspring exposed to maternal caloric restriction.
Topics: Animals; Arginine; Caloric Restriction; Female; Hypertension; In Vitro Techniques; Kidney; Male; Melatonin; Nitric Oxide; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 2014 |
Asymmetric and symmetric dimethylarginine are associated with coronary artery lesions in Kawasaki disease.
Topics: Arginine; Biomarkers; Child, Preschool; Coronary Artery Disease; Coronary Vessels; Female; Humans; Immunoglobulins, Intravenous; Infant; Male; Mucocutaneous Lymph Node Syndrome | 2014 |
Simultaneous determination of N(G)-monomethyl-L-arginine, N(G),N(G)-dimethyl-L-arginine, N(G),N(G')-dimethyl-L-arginine, and L-arginine using monolithic silica disk-packed spin columns and a monolithic silica column.
Topics: Arginine; Calibration; Chromatography, High Pressure Liquid; Fluorescent Dyes; Healthy Volunteers; Humans; Linear Models; omega-N-Methylarginine; Reproducibility of Results; Silicon Dioxide; Solid Phase Extraction | 2014 |
miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia.
Topics: Amidohydrolases; Animals; Arginine; Cells, Cultured; Cyclic GMP; Endothelial Cells; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypoxia; Lung; Male; Mice; Mice, Transgenic; MicroRNAs; Myocytes, Smooth Muscle | 2014 |
Involvement of increased endogenous asymmetric dimethylarginine in the hepatic endoplasmic reticulum stress of type 2 diabetic rats.
Topics: Animals; Arginine; Cell Line, Tumor; Diabetes Mellitus, Type 2; Endoplasmic Reticulum Stress; Liver; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Signal Transduction | 2014 |
GC-MS and GC-MS/MS measurement of the cardiovascular risk factor homoarginine in biological samples.
Topics: Arginine; Cardiovascular Diseases; Female; Gas Chromatography-Mass Spectrometry; Homoarginine; Humans; Male; Risk Factors; Sputum | 2014 |
Asymmetric dimethylarginine and progression of chronic kidney disease: a one-year follow-up study.
Topics: Advanced Oxidation Protein Products; Aged; Arginine; Biomarkers; Case-Control Studies; Disease Progression; Female; Follow-Up Studies; Glomerular Filtration Rate; Glycation End Products, Advanced; Humans; Longitudinal Studies; Male; Middle Aged; Oxidative Stress; Prognosis; Prospective Studies; Renal Insufficiency, Chronic | 2014 |
Serum reference intervals of homoarginine, ADMA, and SDMA in the study of health in Pomerania.
Topics: Adult; Aged; Arginine; Biomarkers; Body Mass Index; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Female; Homoarginine; Humans; Male; Middle Aged; Reference Values; Renal Insufficiency, Chronic; Risk Factors; Tandem Mass Spectrometry | 2014 |
Time course of asymmetric dimethylarginine and symmetric dimethylarginine levels after successful renal transplantation.
Topics: Adult; Aged; Arginine; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Glomerular Filtration Rate; Humans; Kidney Transplantation; Male; Middle Aged; Postoperative Complications; Prospective Studies; Renal Insufficiency, Chronic; Risk Factors; Young Adult | 2014 |
Asymmetric dimethylarginine is associated with high-sensitivity C-reactive protein and early carotid atherosclerosis in women with previous gestational diabetes mellitus.
Topics: Adult; Arginine; C-Reactive Protein; Carotid Artery Diseases; Carotid Intima-Media Thickness; Diabetes, Gestational; Female; Humans; Inflammation; Pregnancy | 2015 |
Asymmetric dimethylarginine, race, and mortality in hemodialysis patients.
Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Black or African American; Boston; Cause of Death; Female; Humans; Kidney Failure, Chronic; Linear Models; Male; Middle Aged; Multivariate Analysis; Prognosis; Proportional Hazards Models; Renal Dialysis; Risk Factors; Time Factors | 2014 |
Role of alanine:glyoxylate aminotransferase 2 in metabolism of asymmetric dimethylarginine in the settings of asymmetric dimethylarginine overload and bilateral nephrectomy.
Topics: Acute Kidney Injury; Alanine; Animals; Arginine; Biomarkers; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Infusions, Intravenous; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Nephrectomy; Real-Time Polymerase Chain Reaction; RNA; Transaminases | 2014 |
Circulating dickkopf-1 in diabetes mellitus: association with platelet activation and effects of improved metabolic control and low-dose aspirin.
Topics: Aged; Arginine; Aspirin; Biomarkers; Cardiovascular Diseases; Case-Control Studies; CD40 Ligand; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Intercellular Signaling Peptides and Proteins; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Thromboxane B2; Wnt Signaling Pathway | 2014 |
Association between brachial-ankle pulse wave velocity and the ratio of l-arginine to asymmetric dimethylarginine in patients undergoing coronary angiography.
Topics: Aged; Ankle Brachial Index; Arginine; Blood Pressure; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studies; Female; Heart Rate; Hematocrit; Hemoglobins; Humans; Kidney; Male; Middle Aged; Natriuretic Peptide, Brain; Pulse Wave Analysis; Vascular Stiffness | 2015 |
Relationship between asymmetric dimethylarginine and nocturia in the general elderly population: The HEIJO-KYO cohort.
Topics: Aged; Aged, 80 and over; Arginine; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Nocturia; Prevalence | 2015 |
Successful catheter ablation decreases platelet activation and improves endothelial function in patients with atrial fibrillation.
Topics: Aged; Arginine; Atrial Fibrillation; Biomarkers; Catheter Ablation; Electrocardiography; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Integrin beta3; Male; Middle Aged; P-Selectin; Platelet Activation; Prospective Studies; Recurrence; Stroke | 2014 |
Asymmetric dimethylarginine (ADMA) and treatment response relationship in male patients with first-episode schizophrenia: a controlled study.
Topics: Adult; Antipsychotic Agents; Arginine; Humans; Male; Middle Aged; Nitric Oxide; Schizophrenia; Treatment Outcome; Young Adult | 2014 |
Changes in serum asymmetric dimethylarginine and endothelial markers levels with varying periods of hemodialysis.
Topics: Adult; Aged; Arginine; Case-Control Studies; Female; Humans; Intercellular Adhesion Molecule-1; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Renal Dialysis; Time Factors; Vascular Cell Adhesion Molecule-1 | 2014 |
Rho/ROCK signal cascade mediates asymmetric dimethylarginine-induced vascular smooth muscle cells migration and phenotype change.
Topics: Animals; Arginine; Biomarkers; Cell Differentiation; Cell Movement; Cell Proliferation; Cell Shape; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenotype; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2014 |
Aging of the nitric oxide system: are we as old as our NO?
Topics: Aged; Aging; Arginine; Blood Platelets; Cardiovascular Diseases; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitric Oxide; Platelet Aggregation; Prospective Studies | 2014 |
The ability of asymmetric dimethylarginine (ADMA) or monomethylarginine (L-NMMA) to block endothelium-dependent, nitric oxide-mediated relaxation in rat aorta is inversely related to the efficacy of the relaxant stimulus.
Topics: Animals; Aorta; Arginine; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Wistar; Vasodilation | 2014 |
Propargylglycine aggravates liver damage in LPS-treated rats: Possible relation of nitrosative stress with the inhibition of H2S formation.
Topics: Alkynes; Amidohydrolases; Animals; Arginine; Aspartate Aminotransferases; Chromatography, High Pressure Liquid; Cystathionine gamma-Lyase; Endotoxemia; Glutathione; Glycine; Hydrogen Sulfide; Lipopolysaccharides; Liver Diseases; Male; Peroxidase; Rats; Rats, Wistar; Stress, Physiological; Tyrosine | 2014 |
Competitive interaction between fibroblast growth factor 23 and asymmetric dimethylarginine in patients with CKD.
Topics: Adult; Aged; Arginine; Cohort Studies; Disease Progression; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Humans; Italy; Male; Middle Aged; Renal Insufficiency, Chronic | 2015 |
Irbesartan inhibits advanced glycation end product-induced increase in asymmetric dimethylarginine level in mesangial cells through its anti-oxidative properties.
Topics: Antioxidants; Arginine; Biphenyl Compounds; Cells, Cultured; Glycation End Products, Advanced; Humans; Irbesartan; Mesangial Cells; Tetrazoles | 2014 |
Metformin reduces asymmetric dimethylarginine and prevents hypertension in spontaneously hypertensive rats.
Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Body Weight; Hypertension; Kidney; Lung; Male; Metformin; Nitric Oxide; Rats, Inbred SHR; Rats, Inbred WKY | 2014 |
Risk of acute cerebral infarction and plasma asymmetrical dimethylarginine and homocysteine levels: a clinical correlation analysis of Chinese population.
Topics: Aged; Arginine; Asian People; Case-Control Studies; Cerebral Infarction; China; Female; Homocysteine; Humans; Male; Middle Aged; Risk; Risk Factors; Socioeconomic Factors | 2014 |
Circulating asymmetric dimethylarginine and lipid profile in pre-pubertal children with growth hormone deficiency: effect of 12-month growth hormone replacement therapy.
Topics: Arginine; Blood Glucose; Case-Control Studies; Child; Female; Follow-Up Studies; Growth Disorders; Hormone Replacement Therapy; Human Growth Hormone; Humans; Insulin Resistance; Lipid Metabolism; Lipids; Male; Puberty; Time Factors | 2014 |
Plasma homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in patients with rheumatoid arthritis: is homoarginine a cardiovascular corrective in rheumatoid arthritis, an anti-ADMA?
Topics: Arginine; Arthritis, Rheumatoid; Biomarkers; Female; Homoarginine; Humans; Male | 2014 |
Possible role of nitric oxide (NO) in the regulation of gender related differences in stress induced anxiogenesis in rats.
Topics: Androstenedione; Animals; Anxiety; Arginine; Behavior, Animal; Brain; Enzyme Inhibitors; Female; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Sex Factors; Stress, Physiological | 2014 |
Omega-3 fatty acids supplementation improves endothelial function and maximal oxygen uptake in endurance-trained athletes.
Topics: Adolescent; Adult; Arginine; Bicycling; Dietary Supplements; Endothelium; Fatty Acids, Omega-3; Humans; Male; Nitric Oxide; Oxygen Consumption; Physical Fitness; Pulse Wave Analysis; Ultrasonography; Vasodilation; Young Adult | 2015 |
Cumulative inflammation associates with asymmetric dimethylarginine in rheumatoid arthritis: a 6 year follow-up study.
Topics: Aged; Arginine; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; C-Reactive Protein; Cardiovascular Diseases; Cohort Studies; Disease Progression; Female; Follow-Up Studies; Humans; Inflammation; Longitudinal Studies; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Regression Analysis; Risk Factors; Severity of Illness Index | 2015 |
Relationship between dimethylarginine dimethylaminohydrolase gene variants and asymmetric dimethylarginine in patients with rheumatoid arthritis.
Topics: Aged; Amidohydrolases; Analysis of Variance; Arginine; Arthritis, Rheumatoid; Female; Genetic Variation; Humans; Inflammation; Insulin Resistance; Male; Middle Aged; Multivariate Analysis; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Risk Factors; Treatment Outcome | 2014 |
Early exercise training after renal transplantation and asymmetric dimethylarginine: the effect of obesity.
Topics: Adult; Aged; Anthropometry; Arginine; Blood Pressure; Cohort Studies; Exercise Therapy; Female; Glycated Hemoglobin; Humans; Insulin; Kidney Transplantation; Lipids; Male; Middle Aged; Obesity; Physical Fitness; Prospective Studies | 2014 |
Asymmetric dimethylarginine triggers macrophage apoptosis via the endoplasmic reticulum stress pathway.
Topics: Apoptosis; Arginine; Blotting, Western; Caspases, Initiator; Cell Line, Tumor; Dose-Response Relationship, Drug; eIF-2 Kinase; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Endoribonucleases; Heat-Shock Proteins; Humans; JNK Mitogen-Activated Protein Kinases; Macrophages; Models, Biological; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Time Factors; Transcription Factor CHOP | 2015 |
Levels of arginine and its products in dialysis patients.
Topics: Adult; Aged; Arginine; Coronary Artery Disease; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Renal Dialysis | 2014 |
Cardiovascular-renal changes after kidney donation: one-year follow-up study.
Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Interleukin-6; Kidney Diseases; Male; Middle Aged; Multivariate Analysis; Nephrectomy; Prospective Studies; Risk Factors; Time Factors; Tissue Donors; Treatment Outcome; Uric Acid; Vascular Cell Adhesion Molecule-1; Vasodilation; Young Adult | 2015 |
Monocyte activation, but not microbial translocation, is independently associated with markers of endovascular dysfunction in HIV-infected patients receiving cART.
Topics: Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Arginine; Bacterial Translocation; Biomarkers; Cardiovascular Diseases; Female; Fibrin Fibrinogen Degradation Products; HIV Infections; Humans; Lipopolysaccharide Receptors; Lipopolysaccharides; Male; Middle Aged; Monocytes | 2014 |
Could plasma asymmetric dimethylarginine level be a novel predictor beyond the classic predictors of stent restenosis?
Topics: Arginine; Biomarkers; C-Reactive Protein; Coronary Angiography; Coronary Restenosis; Cross-Sectional Studies; Female; Humans; Logistic Models; Male; Predictive Value of Tests | 2014 |
Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension.
Topics: Animals; Antioxidants; Arginine; Biomarkers; Blood Pressure; Blood Vessels; Desoxycorticosterone Acetate; Endothelium, Vascular; Fluorescent Antibody Technique; Histones; Hydrogen Sulfide; Hypertension; Lysine; Male; Methylation; Nitrites; Rats, Wistar; Renal Artery; Resveratrol; Stilbenes; Systole; Vasodilation | 2015 |
Is arginine/asymetric dimethylarginine ratio depletion an indicator of insufficient resuscitation in a porcine model of hemorrhage-reperfusion?
Topics: Animals; Arginine; Biomarkers; Chromatography, Liquid; Citrulline; Female; Fluid Therapy; Interleukin-6; Male; Mass Spectrometry; Resuscitation; Shock, Hemorrhagic; Sus scrofa | 2014 |
Discussion.
Topics: Animals; Arginine; Female; Fluid Therapy; Male; Resuscitation; Shock, Hemorrhagic | 2014 |
Changes in ADMA/DDAH pathway after hepatic ischemia/reperfusion injury in rats: the role of bile.
Topics: Amidohydrolases; Animals; Arginine; Bile; Cationic Amino Acid Transporter 2; Disease Models, Animal; Liver; Male; Organ Specificity; Oxidative Stress; Protein-Arginine N-Methyltransferases; Rats; Rats, Wistar; Reperfusion Injury | 2014 |
[Effect of matrine on NO and ADMA metabolism pathways in serum and tissues of mice with lipopolysaccharide-induced intestine tissue inflammation].
Topics: Alkaloids; Animals; Arginine; Humans; Inflammation; Intestinal Diseases; Intestinal Mucosa; Intestines; Lipopolysaccharides; Male; Matrines; Mice; Nitric Oxide; Protein-Arginine N-Methyltransferases; Quinolizines | 2014 |
Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine.
Topics: Adult; Aged; Amidohydrolases; Arginine; Binding Sites; Cohort Studies; Female; Genetic Loci; Genome-Wide Association Study; Genotype; HEK293 Cells; Humans; Male; Mediator Complex; Middle Aged; Polymorphism, Single Nucleotide; Protein Structure, Tertiary; Risk Factors; Stroke; Substrate Specificity; Transaminases | 2014 |
High-tone external muscle stimulation in patients with acute kidney injury (AKI): beneficial effects on NO metabolism, asymmetric dimethylarginine, and endothelin-1.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Arginine; Cohort Studies; Electric Stimulation Therapy; Endothelin-1; Female; Humans; Leg; Male; Middle Aged; Muscle, Skeletal; Nitric Oxide; Renal Dialysis | 2014 |
Antidiabetic drug metformin is effective on the metabolism of asymmetric dimethylarginine in experimental liver injury.
Topics: Alanine Transaminase; Amidohydrolases; Animals; Arginine; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione; Hypoglycemic Agents; Lipopolysaccharides; Male; Metformin; Peroxidase; Protective Agents; Rats; Rats, Sprague-Dawley | 2014 |
IGF-1 and ADMA levels are inversely correlated in nondiabetic ankylosing spondylitis patients undergoing anti-TNF-alpha therapy.
Topics: Adipokines; Antibodies, Monoclonal; Arginine; Female; Humans; Inflammation; Infliximab; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Male; Metabolic Syndrome; Nitric Oxide; Nitric Oxide Synthase; Osteopontin; Osteoporosis; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha | 2014 |
Serelaxin reduces oxidative stress and asymmetric dimethylarginine in angiotensin II-induced hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Arginine; Arterial Pressure; Dinoprost; Disease Models, Animal; Down-Regulation; Humans; Hypertension; Injections, Subcutaneous; Kidney; Liver; Male; NADPH Oxidases; Nitric Oxide; Oxidative Stress; Proteinuria; Rats, Sprague-Dawley; Recombinant Proteins; Relaxin; Thiobarbituric Acid Reactive Substances | 2014 |
Cardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regulation of DDAH/ADMA metabolism pathway in rats.
Topics: Alkaloids; Amidohydrolases; Animals; Arginine; Cardiotonic Agents; Disease Models, Animal; Female; Heart Failure; Hemodynamics; Isoproterenol; Male; Metabolic Networks and Pathways; Myocardium; Natriuretic Peptide, Brain; Organ Size; Protein-Arginine N-Methyltransferases; Quinolizines; Rats; Rats, Sprague-Dawley; Troponin I | 2014 |
Plasma asymmetric dimethylarginine levels are increased in neonates with bronchopulmonary dysplasia-associated pulmonary hypertension.
Topics: Arginine; Bronchopulmonary Dysplasia; Case-Control Studies; Humans; Hypertension, Pulmonary; Infant, Newborn | 2015 |
Asymmetric dimethylarginine attenuates the association of melatonin secretion with night-time blood pressure and dipping in elderly individuals.
Topics: Aged; Aged, 80 and over; Aging; Arginine; Blood Pressure; Body Mass Index; Circadian Rhythm; Cross-Sectional Studies; Diabetes Mellitus; Endothelium, Vascular; Female; Humans; Hypertension; Male; Melatonin; Nitric Oxide; Nitric Oxide Synthase Type III; Secretory Rate; Smoking | 2014 |
Circulating levels of apelin, glucagon-like peptide and visfatin in hypercholesterolemic-hyperhomocysteinemic guinea-pigs: their relation with NO metabolism.
Topics: Animals; Arginine; Cholesterol; Glucagon-Like Peptides; Guinea Pigs; Humans; Hyperhomocysteinemia; Intercellular Signaling Peptides and Proteins; Male; Nicotinamide Phosphoribosyltransferase; Nitric Oxide; Tyrosine | 2015 |
Effects of apocynin, an NADPH oxidase inhibitor, on levels of ADMA, MPO, iNOS and TLR4 induced by myocardial ischemia reperfusion.
Topics: Acetophenones; Animals; Arginine; Male; Myocardial Reperfusion Injury; Myocardium; NADPH Oxidases; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Sprague-Dawley; Toll-Like Receptor 4 | 2015 |
Synergism between asymmetric dimethylarginine (ADMA) and a genetic marker of uric acid in CKD progression.
Topics: Aged; Alleles; Arginine; C-Reactive Protein; Calcium; Case-Control Studies; Cohort Studies; Creatinine; Disease Progression; Endpoint Determination; Female; Follow-Up Studies; Genetic Markers; Glucose Transport Proteins, Facilitative; Hemoglobins; Humans; Hyperuricemia; Male; Middle Aged; Nitric Oxide Synthase; Polymorphism, Single Nucleotide; Proportional Hazards Models; Renal Insufficiency, Chronic; Serum Albumin; Uric Acid | 2015 |
Immunomodulatory and antioxidant function of albumin stabilises the endothelium and improves survival in a rodent model of chronic liver failure.
Topics: Albumins; Animals; Arginine; Disease Models, Animal; End Stage Liver Disease; Endothelium, Vascular; Hemodynamics; Humans; Inflammation; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; von Willebrand Factor | 2015 |
Plasma asymmetric dimethylarginine in infants with bronchopulmonary dysplasia: a promising biomarker despite uncertain pathogenic significance.
Topics: Arginine; Bronchopulmonary Dysplasia; Humans; Hypertension, Pulmonary | 2015 |
Renal transplantation promptly restores excretory function but disturbed L-arginine metabolism persists in patients during the early period after surgery.
Topics: Adult; Arginine; Citrulline; Creatinine; Female; Humans; Kidney Transplantation; Male; Middle Aged; Nitric Oxide; Postoperative Complications; Young Adult | 2015 |
Effect of 18β-glycyrrhetinic acid on cerebral vasospasm caused by asymmetric dimethylarginine after experimental subarachnoid hemorrhage in rats.
Topics: Animals; Arginine; Basilar Artery; Blotting, Western; Connexin 43; Connexins; Disease Models, Animal; Glycyrrhetinic Acid; Neuroprotective Agents; Random Allocation; Rats, Sprague-Dawley; Severity of Illness Index; Subarachnoid Hemorrhage; Time Factors; Vasospasm, Intracranial | 2015 |
Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs.
Topics: Adult; Animals; Anti-Inflammatory Agents; Arginine; Biomarkers; Cardiovascular Diseases; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Culture Techniques; Young Adult | 2015 |
Asymmetric dimethylarginine is associated with carotid atherosclerosis in patients with essential hypertension.
Topics: Arginine; Atherosclerosis; Biomarkers; Blood Pressure; Carotid Artery Diseases; Carotid Artery, Common; Carotid Artery, Internal; Carotid Intima-Media Thickness; Essential Hypertension; Female; Humans; Hypertension; Male; Middle Aged; Retrospective Studies; Ultrasonography, Doppler | 2015 |
Asymmetric dimethylarginine exacerbates Aβ-induced toxicity and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Arginine; Caenorhabditis elegans; Disease Models, Animal; Gene Knockdown Techniques; Humans; MAP Kinase Signaling System; Oxidative Stress; Protein-Arginine N-Methyltransferases; Repressor Proteins | 2015 |
Glycated peptides are associated with the variability of endothelial dysfunction in the cerebral vessels and the kidney in type 2 diabetes mellitus patients: a cross-sectional study.
Topics: Aged; Albuminuria; Arginine; Biomarkers; Breath Holding; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Endothelium, Vascular; Female; Glomerular Filtration Rate; Glycation End Products, Advanced; Humans; Kidney; Male; Middle Aged; Outpatient Clinics, Hospital; Romania; Severity of Illness Index; Vasculitis, Central Nervous System | 2015 |
Endothelial dysfunction and insulin resistance in young women with polycystic ovarian syndrome.
Topics: Adult; Arginine; Body Mass Index; Endothelium, Vascular; Female; Humans; Insulin Resistance; Nitric Oxide; Polycystic Ovary Syndrome; Young Adult | 2014 |
Asymmetric dimethyl arginine levels in chronic hemodialysis patients.
Topics: Adult; Aged; Arginine; Biomarkers; C-Reactive Protein; Case-Control Studies; Cholesterol; Cross-Sectional Studies; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Serum Albumin | 2014 |
Soluble CD14 is associated with markers of vascular dysfunction in bariatric surgery patients.
Topics: Adipose Tissue; Adult; Age Factors; Arginine; Bariatric Surgery; Biomarkers; Female; Humans; Lipopolysaccharide Receptors; Lipopolysaccharides; Male; Middle Aged; Monocytes; Obesity; Prospective Studies; Risk Factors; Sex Factors; Vascular Diseases | 2015 |
Plasma arginine/ADMA ratio as a sensitive risk marker for atherosclerosis: Shimane CoHRE study.
Topics: Aged; Arginine; Atherosclerosis; Biomarkers; Blood Pressure; Body Mass Index; Carotid Arteries; Carotid Artery, Common; Carotid Intima-Media Thickness; Cohort Studies; Cross-Sectional Studies; Female; Humans; Hypertension; Japan; Male; Middle Aged; Risk Factors | 2015 |
Relationship between asymmetric dimethylarginine plasma level and left ventricular mass in hemodialysis patients.
Topics: Adult; Arginine; Female; Glomerular Filtration Rate; Humans; Hypertension; Hypertrophy, Left Ventricular; Kidney Failure, Chronic; Male; Middle Aged; Organ Size; Renal Dialysis; Ultrasonography; Ventricular Dysfunction, Left | 2015 |
[The relationship between serum asymmetric dimethylarginine and ABCD2 score in transient ischemic attack patients].
Topics: Arginine; Case-Control Studies; Cerebral Infarction; Humans; Ischemic Attack, Transient; Risk Factors; Stroke | 2014 |
Plasma Homocysteine and Asymmetrical Dimethyl-l-Arginine (ADMA) and Whole Blood DNA Methylation in Early and Neovascular Age-Related Macular Degeneration: A Pilot Study.
Topics: Aged; Aged, 80 and over; Arginine; Case-Control Studies; DNA; DNA Methylation; Female; Homocysteine; Humans; Male; Pilot Projects; Risk Factors; Wet Macular Degeneration | 2016 |
The association between coronary atherosclerotic burden and asymmetric dimethylarginine, carotis intima media thickness and endothelial function.
Topics: Aged; Arginine; Biomarkers; Brachial Artery; Carotid Intima-Media Thickness; Cholesterol; Cholesterol, LDL; Coronary Artery Disease; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Predictive Value of Tests; Severity of Illness Index; Triglycerides | 2014 |
Association between endothelial and platelet function markers and adiponectin in renal transplanted recipients on cyclosporine and tacrolimus immunosuppression based therapy.
Topics: Adiponectin; Adult; Arginine; Biomarkers; Blood Platelets; Case-Control Studies; Cyclosporine; Drug Therapy, Combination; Endothelial Cells; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; P-Selectin; Platelet Aggregation; Platelet Function Tests; Risk Factors; Tacrolimus; Treatment Outcome; Up-Regulation; Young Adult | 2015 |
Novel peptide chemistry in terrestrial animals: natural luciferin analogues from the bioluminescent earthworm Fridericia heliota.
Topics: Animals; Arginine; Firefly Luciferin; gamma-Aminobutyric Acid; Luminescent Agents; Magnetic Resonance Spectroscopy; Oligochaeta; Peptides | 2015 |
Investigation of subclinical atherosclerosis in psoriatic arthritis patients with minimal disease activity.
Topics: Adult; Arginine; Arthritis, Psoriatic; Asymptomatic Diseases; Atherosclerosis; Brachial Artery; Cardiovascular Diseases; Carotid Arteries; Carotid Intima-Media Thickness; Cross-Sectional Studies; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Plaque, Atherosclerotic; Severity of Illness Index; Vasodilation | 2015 |
Activation of nuclear factor erythroid 2-related factor 2 coordinates dimethylarginine dimethylaminohydrolase/PPAR-γ/endothelial nitric oxide synthase pathways that enhance nitric oxide generation in human glomerular endothelial cells.
Topics: Arginine; Blotting, Western; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation; Humans; Kidney Glomerulus; NF-E2-Related Factor 2; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; PPAR gamma; Real-Time Polymerase Chain Reaction; RNA | 2015 |
Accelerated onset of senescence of endothelial progenitor cells in patients with type 2 diabetes mellitus: role of dimethylarginine dimethylaminohydrolase 2 and asymmetric dimethylarginine.
Topics: Amidohydrolases; Arginine; Cellular Senescence; Diabetes Mellitus, Type 2; Endothelial Progenitor Cells; Female; Humans; Male; Middle Aged; Sirtuin 1 | 2015 |
Serum homocysteine, asymmetric dimethyl arginine (ADMA) and other arginine-NO pathway metabolite levels in patients with psoriasis.
Topics: Adult; Arginine; Biomarkers; Enzyme Inhibitors; Female; Homocysteine; Humans; Male; Middle Aged; Nitric Oxide; Psoriasis; Signal Transduction; Young Adult | 2015 |
Early childhood hospitalisation with infection and subclinical atherosclerosis in adulthood: the Cardiovascular Risk in Young Finns Study.
Topics: Adult; Age of Onset; Arginine; Asymptomatic Diseases; Biomarkers; Brachial Artery; Carotid Arteries; Carotid Artery Diseases; Carotid Intima-Media Thickness; Child; Child, Preschool; Communicable Diseases; Female; Finland; Hospitalization; Humans; Infant; Infant, Newborn; Longitudinal Studies; Male; Phenotype; Prognosis; Prospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Time Factors; Vascular Stiffness; Vasodilation; Young Adult | 2015 |
CT-1 induces angiogenesis by regulating the ADMA/DDAH Pathway.
Topics: Amidohydrolases; Arginine; Cell Migration Assays; Cell Movement; Cell Proliferation; Cells, Cultured; Cytokines; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III; RNA, Messenger; Signal Transduction; Tetraspanin 24; Transfection; Vascular Endothelial Growth Factor A | 2015 |
Asymmetric Dimethyl-L-Arginine is a Biomarker for Disease Stage and Follow-Up of Pulmonary Hypertension Associated with Congenital Heart Disease.
Topics: Adult; Arginine; Biomarkers; Female; Follow-Up Studies; Heart Defects, Congenital; Humans; Hypertension, Pulmonary; Male; Middle Aged; Prospective Studies; Pulmonary Artery; Sildenafil Citrate; Treatment Outcome; Vascular Resistance; Vasodilator Agents; Young Adult | 2015 |
Novel markers of endothelial dysfunction and inflammation in Behçet's disease patients with ocular involvement: epicardial fat thickness, carotid intima media thickness, serum ADMA level, and neutrophil-to-lymphocyte ratio.
Topics: Adipose Tissue; Adult; Arginine; Behcet Syndrome; Biomarkers; Carotid Intima-Media Thickness; Cross-Sectional Studies; Echocardiography; Endothelium, Vascular; Eye; Female; Humans; Inflammation; Leukocyte Count; Lymphocytes; Male; Neutrophils; Pericardium | 2016 |
Exercise-induced vasodilation in healthy males: A marker of reduced endothelial function.
Topics: Adult; Aged; Arginine; Biomarkers; Endothelium, Vascular; Exercise; Exercise Test; Humans; Hyperemia; Inflammation; Interleukin-10; Male; Middle Aged; Plethysmography, Impedance; Statistics as Topic; Vasodilation | 2015 |
The role of asymmetric and symmetric dimethylarginine in acute deep vein thrombosis.
Topics: Acute Disease; Adult; Arginine; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Treatment Outcome; Venous Thrombosis | 2015 |
A reduction of asymmetric dimethylarginine in renal transplant recipients receiving sirolimus-based regimen.
Topics: Arginine; Calcineurin Inhibitors; Cross-Sectional Studies; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Sirolimus; Transplant Recipients | 2015 |
Relationship between Dietary Approaches to Stop Hypertension score and Alternative Healthy Eating Index score with plasma asymmetrical dimethylarginine levels in patients referring for coronary angiography.
Topics: Aged; Arginine; Coronary Angiography; Coronary Disease; Coronary Stenosis; Cross-Sectional Studies; Diet; Energy Intake; Female; Health Promotion; Humans; Hypertension; Iran; Male; Middle Aged | 2015 |
Nitric oxide dysregulation in patients with heart failure: the association of depressive symptoms with L-arginine, asymmetric dimethylarginine, symmetric dimethylarginine, and isoprostane.
Topics: Aged; Arginine; Depression; Female; Heart Failure; Humans; Isoprostanes; Linear Models; Male; Middle Aged; Nitric Oxide; Oxidative Stress | 2015 |
Plasma asymmetric and symmetric dimethylarginine in a rat model of endothelial dysfunction induced by acute hyperhomocysteinemia.
Topics: Amidohydrolases; Animals; Arginine; Cathepsin D; Disease Models, Animal; Endothelium, Vascular; Gene Expression Regulation; Hyperhomocysteinemia; Liver; Male; Methionine; Rats; Rats, Wistar; Ubiquitin | 2015 |
Packed red blood cells are an abundant and proximate potential source of nitric oxide synthase inhibition.
Topics: Animals; Arginine; Catalase; Enzyme Inhibitors; Erythrocytes; Humans; Nitric Oxide; Nitric Oxide Synthase; Proteolysis; Rats; Temperature; Time Factors | 2015 |
Interleukin-6 and asymmetric dimethylarginine are associated with platelet activation after percutaneous angioplasty with stent implantation.
Topics: Aged; Angioplasty, Balloon, Coronary; Arginine; Blood Platelets; C-Reactive Protein; Cardiovascular Diseases; Creatinine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Integrin beta3; Interleukin-6; Male; Middle Aged; Monocytes; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoprotein IIb; Risk Factors; Smoking; Stents | 2015 |
Reduced Renal Methylarginine Metabolism Protects against Progressive Kidney Damage.
Topics: Acute Kidney Injury; Adult; Allografts; Amidohydrolases; Animals; Arginine; Collagen Type I; Collagen Type I, alpha 1 Chain; Female; Folic Acid; Gene Expression; Glomerular Filtration Rate; Humans; Kidney Transplantation; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Nitric Oxide; RNA, Messenger; Transaminases; Ureteral Obstruction; Uromodulin | 2015 |
Association of advanced age with concentrations of uraemic toxins in CKD.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Arginine; beta 2-Microglobulin; Biomarkers; Blood Urea Nitrogen; Creatinine; Female; Furans; Humans; Male; Middle Aged; Multivariate Analysis; Propionates; Renal Dialysis; Renal Insufficiency, Chronic; Uremia | 2016 |
Asymmetric dimethylarginine in somatically healthy schizophrenia patients treated with atypical antipsychotics: a case-control study.
Topics: Adult; Antipsychotic Agents; Arginine; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Humans; Male; Oxidative Stress; Schizophrenia | 2015 |
The role of plasma triglyceride/high-density lipoprotein cholesterol ratio to predict cardiovascular outcomes in chronic kidney disease.
Topics: Adult; Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Cholesterol, HDL; Female; Glomerular Filtration Rate; Humans; Longitudinal Studies; Male; Middle Aged; Parathyroid Hormone; Renal Insufficiency, Chronic; Retrospective Studies; Serum Albumin; Triglycerides | 2015 |
Pleiotropic effects of fenofibrate therapy on rats with hypertriglycemia.
Topics: Animals; Apolipoprotein A-I; Arginine; C-Reactive Protein; Cardiotonic Agents; Cholesterol, HDL; Dose-Response Relationship, Drug; Fenofibrate; Hypertriglyceridemia; Hypolipidemic Agents; Male; Malondialdehyde; Nitric Oxide; Rats; Rats, Sprague-Dawley; Triglycerides | 2015 |
Role of asymmetric dimethylarginine in rat acute lung injury induced by acute ischemic kidney injury.
Topics: Actins; Acute Kidney Injury; Acute Lung Injury; Animals; Arginine; Enzyme Activation; HSP27 Heat-Shock Proteins; Ischemia; Kidney; Lung; Male; p38 Mitogen-Activated Protein Kinases; Permeability; Rats, Wistar | 2015 |
Asymmetric dimethylarginine is negatively correlated with hyperglycemia in children.
Topics: Adolescent; Arginine; Biomarkers; Body Mass Index; Cardiovascular Diseases; Child; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Cardiomyopathies; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Hyperglycemia; Japan; Male; Pediatric Obesity; Risk | 2015 |
First-Trimester Maternal Serum Levels of sFLT1, PGF and ADMA Predict Preeclampsia.
Topics: Adult; Area Under Curve; Arginine; Blood Pressure; Case-Control Studies; Demography; Female; Follow-Up Studies; Humans; Logistic Models; Placenta Growth Factor; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; Pregnancy Trimester, First; Pregnancy Trimester, Second; Prospective Studies; ROC Curve; Ultrasonography; Uterine Artery; Vascular Endothelial Growth Factor Receptor-1 | 2015 |
Atorvastatin protects endothelium by decreasing asymmetric dimethylarginine in dyslipidemia rats.
Topics: Animals; Arginine; Atorvastatin; Blood Glucose; Cholesterol; Cholesterol, HDL; Creatine Kinase; Dyslipidemias; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardium; Nitric Oxide; Rats; Rats, Sprague-Dawley; Triglycerides | 2015 |
Association of homoarginine and methylarginines with liver dysfunction and mortality in chronic liver disease.
Topics: Adult; Aged; Arginine; Chronic Disease; Disease-Free Survival; Female; Follow-Up Studies; Homoarginine; Humans; Liver Cirrhosis; Male; Middle Aged; Retrospective Studies; Survival Rate | 2015 |
Physical exercise reduces synthesis of ADMA, SDMA, and L-Arg.
Topics: Arginine; Biomarkers; Coronary Artery Disease; Exercise; Female; Humans; Male; Middle Aged; Nitric Oxide | 2015 |
S100B and ADMA in cerebral small vessel disease and cognitive dysfunction.
Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Cerebral Small Vessel Diseases; Cognition Disorders; Female; Humans; Male; Middle Aged; S100 Calcium Binding Protein beta Subunit; Single-Blind Method | 2015 |
The relationship between serum asymmetric dimethylarginine levels and subjective sleep quality in normotensive patients with type 2 diabetes mellitus.
Topics: Adult; Arginine; Biomarkers; Cardiovascular Diseases; Chi-Square Distribution; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Risk Factors; Sleep; Sleep Wake Disorders; Surveys and Questionnaires | 2015 |
Effect of DDAH/ADMA/NOS regulation pathway on cavernae corporum cavernosorum rat penis of different age.
Topics: Amidohydrolases; Animals; Arginine; Cyclic GMP; Male; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Papaverine; Penis; Rats; Rats, Sprague-Dawley | 2016 |
Assessment of serum asymmetric dimethylarginine levels and left ventricular diastolic function in patients with ankylosing spondylitis.
Topics: Adult; Antirheumatic Agents; Arginine; Biological Products; Biomarkers; Blood Sedimentation; C-Reactive Protein; Case-Control Studies; Cross-Sectional Studies; Diastole; Disability Evaluation; Echocardiography, Doppler; Female; Humans; Male; Nitric Oxide; Spondylitis, Ankylosing; Treatment Outcome; Tumor Necrosis Factor-alpha; Ventricular Function, Left; Young Adult | 2017 |
Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals.
Topics: Animals; Arginine; Arteriosclerosis; Calcinosis; Diabetes Mellitus, Experimental; Dietary Fats; Frizzled Receptors; Gene Expression Regulation; Histones; Low Density Lipoprotein Receptor-Related Protein-6; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteopontin; Paracrine Communication; Protein Interaction Mapping; Protein-Arginine N-Methyltransferases; Receptors, Cell Surface; Receptors, LDL; Upstream Stimulatory Factors; Vascular Stiffness; Wnt Signaling Pathway | 2015 |
Computational Study of Symmetric Methylation on Histone Arginine Catalyzed by Protein Arginine Methyltransferase PRMT5 through QM/MM MD and Free Energy Simulations.
Topics: Arginine; Biocatalysis; Histones; Humans; Kinetics; Methylation; Molecular Dynamics Simulation; Protein-Arginine N-Methyltransferases; Protons; Quantum Theory; S-Adenosylmethionine; Substrate Specificity; Thermodynamics | 2015 |
The Arginine/ADMA Ratio Is Related to the Prevention of Atherosclerotic Plaques in Hypercholesterolemic Rabbits When Giving a Combined Therapy with Atorvastatine and Arginine.
Topics: Animals; Anticholesteremic Agents; Arginine; Atorvastatin; Cholesterol; Dietary Supplements; Hypercholesterolemia; Nitric Oxide; Nitric Oxide Synthase; Plaque, Atherosclerotic; Rabbits | 2015 |
LC-MS/MS for the simultaneous determination of polar endogenous ADMA and CML in plasma and urine from diabetics.
Topics: Arginine; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Linear Models; Lysine; Retrospective Studies; Tandem Mass Spectrometry | 2015 |
L-citrulline for protection of endothelial function from ADMA-induced injury in porcine coronary artery.
Topics: Animals; Arginine; Cardiovascular Agents; Citrulline; Coronary Vessels; Cyclic GMP; Drug Evaluation, Preclinical; Endothelium, Vascular; Nitric Oxide Synthase Type III; Phosphorylation; Protein Processing, Post-Translational; Superoxides; Sus scrofa; Vascular System Injuries | 2015 |
Heat Shock Proteins, L-Arginine, and Asymmetric Dimethylarginine Levels in Patients With Obstructive Sleep Apnea Syndrome.
Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus; Disease Susceptibility; Endothelium, Vascular; Female; Heat-Shock Proteins; Humans; Hypercholesterolemia; Hypertension; Male; Middle Aged; Obesity; Oxidative Stress; Polysomnography; Risk Factors; Sleep Apnea, Obstructive; Smoking; Turkey | 2015 |
Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with COPD.
Topics: Aged; Arginine; Biomarkers; Cross-Sectional Studies; Disease Progression; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Forced Expiratory Volume; Humans; Lung; Male; Middle Aged; Nitric Oxide; Prospective Studies; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Smoking | 2017 |
The effects of atorvastatin on antioxidant/antiinflammatory properties of HDLs in hypercholesterolemics.
Topics: Adult; Anticholesteremic Agents; Arginine; Atorvastatin; Drug Monitoring; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Inflammation; Lipoproteins, HDL; Male; Malondialdehyde; Middle Aged; Nitric Oxide; Oxidative Stress; Pyrroles; Treatment Outcome | 2015 |
Asymmetric dimethyl arginine induces pulmonary vascular dysfunction via activation of signal transducer and activator of transcription 3 and stabilization of hypoxia-inducible factor 1-alpha.
Topics: Amidohydrolases; Arginine; Calcium; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation Mediators; Intercellular Adhesion Molecule-1; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Synthase Type III; Pulmonary Artery; Signal Transduction; STAT3 Transcription Factor | 2015 |
Reference intervals of plasma matrix metalloproteinases 2, 3, and 9 and serum asymmetric dimethylarginine levels.
Topics: Adult; Arginine; Female; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Middle Aged; Reference Values | 2015 |
Veterinary Medicine and Multi-Omics Research for Future Nutrition Targets: Metabolomics and Transcriptomics of the Common Degenerative Mitral Valve Disease in Dogs.
Topics: Animals; Arginine; Blood Glucose; Decision Trees; Dipeptides; Dogs; Glutathione Disulfide; Heart Valve Diseases; Heart Ventricles; High-Throughput Nucleotide Sequencing; Lipid Metabolism; Metabolomics; Mitral Valve; Molecular Sequence Annotation; Nutrition Assessment; Oxidative Stress; Random Allocation; Transcriptome | 2015 |
Atrial Fibrillation Is Associated with a Marker of Endothelial Function and Oxidative Stress in Patients with Acute Myocardial Infarction.
Topics: Aged; Aged, 80 and over; Arginine; Atrial Fibrillation; Biomarkers; Chromatography, High Pressure Liquid; Electrocardiography; Endothelium; Female; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Oxidative Stress; Risk Assessment; Risk Factors | 2015 |
Role of the endogenous nitric oxide inhibitor asymmetric dimethylarginine (ADMA) and brain-derived neurotrophic factor (BDNF) in depression and behavioural changes: clinical and preclinical data in chronic kidney disease.
Topics: Animals; Arginine; Brain-Derived Neurotrophic Factor; Cohort Studies; Cross-Sectional Studies; Depression; Depressive Disorder, Major; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Nephrectomy; Nitric Oxide; Nitric Oxide Synthase; Problem Behavior; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic | 2015 |
Hyperhomocysteinemia: a missing link to dysfunctional HDL via paraoxanase-1.
Topics: Amidohydrolases; Animals; Arginine; Aryldialkylphosphatase; Atherosclerosis; Blood Pressure; Connexins; Diet, Atherogenic; Endothelium, Vascular; Fibrosis; Gap Junction alpha-4 Protein; Gap Junction alpha-5 Protein; Hyperhomocysteinemia; Lipoproteins, HDL; Male; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Ventricular Dysfunction, Left | 2015 |
Blood pressure from childhood to adolescence in obese youths in relation to insulin resistance and asymmetric dimethylarginine.
Topics: Adolescent; Adolescent Development; Arginine; Biomarkers; Blood Pressure Monitoring, Ambulatory; Body Mass Index; Child; Child Development; Disease Progression; Female; Humans; Hypertension; Insulin Resistance; Italy; Lost to Follow-Up; Male; Pediatric Obesity; Prehypertension; Risk Factors; Severity of Illness Index | 2016 |
Dimethylarginines as biomarkers for the kidney transplant management in methylmalonic aciduria.
Topics: Adult; Allografts; Amino Acid Metabolism, Inborn Errors; Arginine; Biomarkers; Cause of Death; Disease Progression; Fatal Outcome; Humans; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Transplantation; Living Donors; Male; Pancreatitis; Predictive Value of Tests; Risk Factors; Time Factors; Treatment Outcome | 2015 |
Serial determinations of asymmetric dimethylarginine and homocysteine during pregnancy to predict pre-eclampsia: a longitudinal study.
Topics: Adult; Arginine; Biomarkers; Body Mass Index; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Longitudinal Studies; Pre-Eclampsia; Predictive Value of Tests; Pregnancy; Risk Factors; United Kingdom; Vitamin B Complex; Vitamin B Deficiency | 2015 |
FoxO1 regulates asymmetric dimethylarginine via downregulation of dimethylaminohydrolase 1 in human endothelial cells and subjects with atherosclerosis.
Topics: Amidohydrolases; Arginine; Carotid Artery Diseases; Cells, Cultured; Chromatography, Liquid; Down-Regulation; Forkhead Box Protein O1; Forkhead Transcription Factors; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation, Enzymologic; Human Umbilical Vein Endothelial Cells; Humans; Metabolomics; Mutation; Signal Transduction; Transfection | 2015 |
Asymmetric dimethylarginine in experimental breast cancer; action of Vitamin C and E.
Topics: Animals; Antioxidants; Arginase; Arginine; Ascorbic Acid; Female; Mammary Neoplasms, Experimental; Mice; Nitric Oxide; Nitric Oxide Synthase; Vitamin E | 2015 |
Increased Plasma Levels of Asymmetric Dimethylarginine in Nonalcoholic Fatty Liver Disease: Relation With Insulin Resistance, Inflammation, and Liver Histology.
Topics: Adult; Arginine; C-Reactive Protein; Case-Control Studies; Female; Humans; Inflammation; Insulin Resistance; Liver; Male; Middle Aged; Non-alcoholic Fatty Liver Disease | 2015 |
The effect of nephropathy on plasma sphingosine 1-phosphate concentrations in patients with type 2 diabetes.
Topics: Albuminuria; Apolipoproteins; Apolipoproteins M; Arginine; Biological Transport; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Lipocalins; Lysophospholipids; Male; Middle Aged; Sphingosine; Triglycerides | 2015 |
Evaluation of ADMA-DDAH-NOS axis in specific brain areas following nitroglycerin administration: study in an animal model of migraine.
Topics: Amidohydrolases; Animals; Arginine; Brain; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Migraine Disorders; Nitric Oxide Synthase Type I; Nitroglycerin; Rats; Rats, Sprague-Dawley | 2015 |
[Interactions between markers of endothelial damage (homocysteine and asymmetric dimethylarginine) and antioxidants and B-vitamins in preeclamptic women].
Topics: Adolescent; Adult; Antioxidants; Arginine; Biomarkers; Cross-Sectional Studies; Female; Homocysteine; Humans; Pre-Eclampsia; Pregnancy; Prospective Studies; Regression Analysis; Vitamin B Complex; Vitamin B Deficiency; Young Adult | 2015 |
Elevated Levels of Asymmetric Dimethylarginine (ADMA) in the Pericardial Fluid of Cardiac Patients Correlate with Cardiac Hypertrophy.
Topics: Adult; Arginine; Cardiomegaly; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Pericardial Fluid; Ventricular Remodeling | 2015 |
The relationship between neutrophil to lymphocyte ratio, endothelial function, and severity in patients with obstructive sleep apnea.
Topics: Adult; Aged; Arginine; Biomarkers; Continuous Positive Airway Pressure; Endothelial Progenitor Cells; Endothelium, Vascular; Female; Humans; Lymphocyte Count; Lymphocytes; Male; Middle Aged; Neutrophils; Nitric Oxide; Prospective Studies; Severity of Illness Index; Sleep Apnea, Obstructive | 2016 |
Endothelial dysfunction in subjects with chronic cadmium exposure.
Topics: Arginine; Biomarkers; Cadmium Compounds; Endothelium, Vascular; Environmental Exposure; Female; Glutathione; Humans; Linear Models; Malondialdehyde; Nitrites; Thrombomodulin; Vascular Diseases | 2015 |
Asymmetric dimethylarginine but not osteoprotegerin correlates with disease severity in patients with moderate-to-severe psoriasis undergoing anti-tumor necrosis factor-α therapy.
Topics: Adalimumab; Adult; Anti-Inflammatory Agents; Arginine; Biological Therapy; Biomarkers; Female; Humans; Male; Middle Aged; Osteoprotegerin; Prospective Studies; Psoriasis; Resistin; Tumor Necrosis Factor-alpha | 2016 |
Increased levels of MMP-3, MMP-9 and MPO represent predictors of in-stent restenosis, while increased levels of ADMA, LCAT, ApoE and ApoD predict bare metal stent patency.
Topics: Aged; Apolipoproteins D; Apolipoproteins E; Arginine; Biomarkers; Case-Control Studies; Coronary Restenosis; Female; Graft Occlusion, Vascular; Humans; Lipoprotein(a); Male; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Middle Aged; Percutaneous Coronary Intervention; Peroxidase; Phosphatidylcholine-Sterol O-Acyltransferase; Stents; Vascular Patency | 2015 |
Endogenous Asymmetric Dimethylarginine Pathway in High Altitude Adapted Yaks.
Topics: Adaptation, Physiological; Altitude; Amidohydrolases; Animals; Arginine; Cattle; Hemodynamics; Lung; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III | 2015 |
Asymmetric dimethylarginine is transported by the mitochondrial carrier SLC25A2.
Topics: Amino Acid Transport Systems, Basic; Arginine; Biological Transport; Carrier Proteins; Cell Line, Tumor; Humans; Kidney Tubules, Proximal; Mitochondria; Mitochondrial Membranes; Transaminases | 2016 |
Asymmetric dimethylarginine is not a good predictor of ischemia using myocardial perfusion scintigraphy.
Topics: Arginine; Coronary Artery Disease; Echocardiography; Female; Humans; Ischemia; Male; Middle Aged; Myocardial Perfusion Imaging; Predictive Value of Tests; Technetium Tc 99m Sestamibi; Tomography, Emission-Computed, Single-Photon | 2015 |
Is left ventricular diastolic function impaired in patients with ankylosing spondylitis?
Topics: Arginine; Diastole; Humans; Spondylitis, Ankylosing; Ventricular Function, Left | 2017 |
Asymmetric dimethylarginine predicts left atrial appendage thrombus in patients with non-valvular atrial fibrillation.
Topics: Aged; Arginine; Atrial Appendage; Atrial Fibrillation; Female; Humans; Male; Middle Aged; Nitric Oxide; Thrombosis | 2015 |
Icariin regulates PRMT/ADMA/DDAH pathway to improve endothelial function.
Topics: Amidohydrolases; Animals; Aorta; Apolipoproteins E; Arginine; Flavonoids; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Knockout; Protein-Arginine N-Methyltransferases; Reactive Oxygen Species; Signal Transduction; Vasodilation | 2015 |
Effects of captopril, telmisartan and bardoxolone methyl (CDDO-Me) in ischemia-reperfusion-induced acute kidney injury in rats: an experimental comparative study.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Antioxidants; Apoptosis; Arginine; Benzimidazoles; Benzoates; Captopril; Creatine; Endothelin-1; Gene Expression Regulation; Glutathione Peroxidase; Ischemia; Kidney; Lipocalin-2; Lipocalins; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oleanolic Acid; Proto-Oncogene Proteins; Rats; Rats, Wistar; Reperfusion Injury; Sulfhydryl Compounds; Superoxide Dismutase; Telmisartan; Urea | 2016 |
The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats.
Topics: Adipose Tissue; Amidohydrolases; Animals; Arginine; Blotting, Western; Cells, Cultured; Gene Expression Regulation; Male; Mice; Mice, Transgenic; Nephrectomy; Oxidative Stress; Phenotype; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Renal Insufficiency, Chronic; RNA; Signal Transduction | 2016 |
Osteoprotegerin is Associated With Endothelial Function and Predicts Early Carotid Atherosclerosis in Patients With Coronary Artery Disease.
Topics: Aged; Arginine; Biomarkers; Carotid Artery Diseases; Carotid Intima-Media Thickness; Coronary Angiography; Coronary Artery Disease; Early Diagnosis; Endothelium, Vascular; Female; Humans; Japan; Male; Middle Aged; Osteoprotegerin; Predictive Value of Tests; Risk Assessment; Risk Factors; Severity of Illness Index | 2015 |
ADMA, subclinical changes and atrial fibrillation in the general population.
Topics: Adult; Aged; Arginine; Atrial Fibrillation; Biomarkers; Chromatography, Liquid; Echocardiography; Electrocardiography; Female; Germany; Humans; Male; Middle Aged; Morbidity; omega-N-Methylarginine; Oxidative Stress; Population Surveillance; Tandem Mass Spectrometry | 2016 |
Nitric Oxide-Related Biological Pathways in Patients with Major Depression.
Topics: Adult; Arginase; Arginine; Biological Availability; Case-Control Studies; Demography; Depressive Disorder, Major; Female; Humans; Male; Middle Aged; Nitric Oxide; Psychometrics; Signal Transduction | 2015 |
Hypertension subtypes modify metabolic response to thiazide diuretics.
Topics: Adiponectin; Adult; Antihypertensive Agents; Arginine; Asian People; Blood Glucose; China; Cholesterol; Cohort Studies; Diastole; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Multivariate Analysis; Prospective Studies; Sodium Chloride Symporter Inhibitors; Systole; Treatment Outcome | 2016 |
Associations between asymmetric dimethylarginine, homocysteine, and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism (rs1801133) in rheumatoid arthritis.
Topics: Aged; Analysis of Variance; Arginine; Arthritis, Rheumatoid; Cohort Studies; Female; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Polymorphism, Genetic | 2016 |
Methylarginines in Mice with Experimental Atherosclerosis.
Topics: Animals; Arginine; Atherosclerosis; Cholesterol; Endothelium, Vascular; Male; Mice; Mice, Inbred CBA; Nitric Oxide Synthase; omega-N-Methylarginine; Poloxamer; Triglycerides | 2015 |
Acetylation of asymmetric and symmetric dimethylarginine: an undercharacterized pathway of metabolism of endogenous methylarginines.
Topics: Acetylation; Animals; Arginine; Chromatography, Liquid; Kidney; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Nephrectomy; Organ Specificity; Protein Processing, Post-Translational | 2016 |
ADMA and arginine derivatives in relation to non-invasive vascular function in the general population.
Topics: Adult; Aged; Arginine; Blood Flow Velocity; Brachial Artery; Cardiovascular Diseases; Cross-Sectional Studies; Enzyme Inhibitors; Female; Germany; Humans; Male; Middle Aged; Nitric Oxide Synthase; Population Surveillance; Prevalence; Retrospective Studies; Vasodilation | 2016 |
L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Atherosclerosis; Cross-Sectional Studies; Female; Germany; Humans; Hyperthyroidism; Male; Middle Aged; Regression Analysis; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine; Young Adult | 2016 |
Changes in Biliary Levels of Arginine and its Methylated Derivatives after Hepatic Ischaemia/Reperfusion.
Topics: Alanine Transaminase; Alkaline Phosphatase; Amidohydrolases; Amino Acid Transport Systems, Basic; Animals; Arginine; Aspartate Aminotransferases; Bile; Citrulline; Liver; Liver Diseases; Male; Nitric Oxide; Rats; Rats, Wistar; Reperfusion Injury; RNA, Messenger | 2016 |
Whole-body synthesis of L-homoarginine in pigs and rats supplemented with L-arginine.
Topics: Animal Feed; Animals; Arginine; Body Weight; Creatinine; Dietary Supplements; Female; Glycine max; Homoarginine; Male; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Swine; Zea mays | 2016 |
Low urinary citrulline/arginine ratio associated with blood pressure abnormalities and arterial stiffness in childhood chronic kidney disease.
Topics: Adolescent; Arginine; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Child; Citrulline; Female; Humans; Hypertension; Male; Nitric Oxide; Nitric Oxide Synthase; Pulse Wave Analysis; Renal Insufficiency, Chronic; Taiwan; Vascular Remodeling; Vascular Stiffness | 2016 |
Effect of inflammation by acute sepsis on intact fibroblast growth factor 23 (iFGF23) and asymmetric dimethyl arginine (ADMA) in CKD patients.
Topics: Arginine; Biomarkers; Case-Control Studies; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Glomerular Filtration Rate; Historically Controlled Study; Hospitalization; Humans; Inflammation; Inflammation Mediators; Kidney; Longitudinal Studies; Male; Middle Aged; Renal Insufficiency, Chronic; Sepsis; Time Factors; Treatment Outcome | 2016 |
ADMA--a Possible Marker for Early Therapeutic Outcome in Acute Stroke.
Topics: Aged; Arginine; Biomarkers; Female; Humans; Male; Middle Aged; Stroke; Thrombolytic Therapy | 2015 |
Evaluation of Endothelial (dys)Function, Left Ventricular Structure and Function in Patients with Chronic Kidney Disease.
Topics: Aged; Arginine; Biomarkers; Case-Control Studies; Echocardiography, Doppler; Endothelium, Vascular; Female; Humans; Hypertrophy, Left Ventricular; Male; Middle Aged; Nitric Oxide Synthase Type III; Renal Dialysis; Renal Insufficiency, Chronic; Stroke Volume; Treatment Outcome; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2016 |
Assessment of heat shock proteins and endothelial dysfunction in acute pulmonary embolism.
Topics: Acute Disease; Adult; Aged; Arginine; Biomarkers; Case-Control Studies; Endothelium, Vascular; Female; Gene Expression; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Male; Middle Aged; Molecular Chaperones; Oxidative Stress; Oxygen; Pulmonary Artery; Pulmonary Embolism | 2016 |
Neopterin, homocysteine, and ADMA levels during and after urticaria attack.
Topics: Adult; Aged; Arginine; Biomarkers; Emergency Service, Hospital; Female; Homocysteine; Humans; Male; Middle Aged; Neopterin; Prospective Studies; Urticaria; Young Adult | 2015 |
Apolipoprotein E polymorphism modulation of asymmetric dimethylarginine in hypertensive patients is determined by renal function.
Topics: Alleles; Apolipoproteins E; Arginine; Demography; Female; Humans; Hypertension; Kidney; Kidney Function Tests; Logistic Models; Male; Middle Aged; Polymorphism, Genetic; Racial Groups; Renal Replacement Therapy | 2016 |
DDAH1 deficiency promotes intracellular oxidative stress and cell apoptosis via a miR-21-dependent pathway in mouse embryonic fibroblasts.
Topics: Amidohydrolases; Animals; Apoptosis; Arginine; Embryo, Mammalian; Endothelial Cells; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation; Mice; MicroRNAs; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Signal Transduction; Superoxide Dismutase | 2016 |
Nebivolol ameliorates asymmetric dimethylarginine-induced vascular response in rat aorta via β3 adrenoceptor-mediated mechanism.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic beta-1 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-3 Receptor Antagonists; Animals; Aorta; Arginine; Butoxamine; Enzyme Inhibitors; In Vitro Techniques; Nebivolol; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Pindolol; Rats; Receptors, Adrenergic, beta-3 | 2016 |
Does the ADMA/DDAH/NO pathway modulate early regression of left ventricular hypertrophy with esmolol?
Topics: Adrenergic beta-1 Receptor Antagonists; Amidohydrolases; Animals; Antihypertensive Agents; Arginine; Humans; Hypertension; Hypertrophy, Left Ventricular; Models, Cardiovascular; Nitric Oxide; Propanolamines; Rats; Rats, Inbred SHR; Risk Factors; Signal Transduction; Ventricular Remodeling | 2016 |
Asymmetric dimethylarginine (ADMA) elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbidly obese humans.
Topics: Adipose Tissue; Adult; Aged; Animals; Arginase; Arginine; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Insulin Resistance; Male; Middle Aged; Obesity, Morbid; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Up-Regulation; Vasodilation | 2016 |
[THE CLINICAL LABORATORY MARKERS OF ATHEROSCLEROSIS IN PATIENTS WITH ATHEROTHROMBOTIC STROKE].
Topics: Aged; Aged, 80 and over; Arginine; Atherosclerosis; Biomarkers; C-Reactive Protein; Carotid Stenosis; Case-Control Studies; Female; Humans; Male; Middle Aged; Phospholipases A2; Pregnancy-Associated Plasma Protein-A; Stroke | 2015 |
Increased asymmetric dimethylarginine levels in severe transient tachypnea of the newborn.
Topics: Arginine; Blood Pressure; Female; Humans; Infant, Newborn; Male; Nitric Oxide; Nitric Oxide Synthase; Pulmonary Artery; Severity of Illness Index; Statistics as Topic; Transient Tachypnea of the Newborn | 2016 |
N-methylnicotinamide protects against endothelial dysfunction and attenuates atherogenesis in apolipoprotein E-deficient mice.
Topics: Acetylcholine; Amidohydrolases; Animals; Aorta; Arginine; Atherosclerosis; Cholesterol, Dietary; Cyclic GMP; Diet, High-Fat; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Niacinamide; Nitric Oxide; Promoter Regions, Genetic; Vasodilation | 2016 |
IL-4 promotes asymmetric dimethylarginine accumulation, oxo-nitrative stress, and hypoxic response-induced mitochondrial loss in airway epithelial cells.
Topics: Amidohydrolases; Apoptosis; Arginine; Asthma; Calpain; Cell Line; Cells, Cultured; Cytokines; Epithelial Cells; Humans; Hypoxia; Inflammation Mediators; Interleukin-4; Mitochondria; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Proteolysis; Reactive Oxygen Species; Respiratory Mucosa | 2016 |
Serum trans fatty acids, asymmetric dimethylarginine and risk of acute myocardial infarction and mortality in patients with suspected coronary heart disease: a prospective cohort study.
Topics: Aged; Arginine; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Trans Fatty Acids | 2016 |
Ageing/Menopausal Status in Healthy Women and Ageing in Healthy Men Differently Affect Cardiometabolic Parameters.
Topics: Adult; Aging; Arginine; Blood; Body Weight; Female; Humans; Interleukin-6; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Postmenopause; Premenopause; Protein Carbonylation; Risk Factors; Triglycerides; Tumor Necrosis Factor-alpha | 2016 |
The effect of varicocoelectomy on the relationship of oxidative stress in peripheral and internal spermatic vein with semen parameters.
Topics: Adult; Arginine; Glutathione; Humans; Infertility, Male; Male; Oxidative Stress; Reactive Oxygen Species; Semen Analysis; Superoxide Dismutase; Treatment Outcome; Varicocele; Young Adult | 2016 |
The separation and analysis of symmetric and asymmetric dimethylarginine and other hydrophilic isobaric compounds using aqueous normal phase chromatography.
Topics: Arginine; Case-Control Studies; Chromatography, Liquid; Humans; Hydrophobic and Hydrophilic Interactions; Silicates; Tuberculosis, Pulmonary; Water | 2016 |
Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells.
Topics: Animals; Arginine; Carrier Proteins; Disease Models, Animal; Endothelial Cells; Genes, Dominant; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Lung; Mitochondria; Nitric Oxide Synthase Type III; Phosphorylation; Proteasome Endopeptidase Complex; Protein Binding; Proteolysis; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Regional Blood Flow; Sheep; Ubiquitination | 2016 |
ADMA: a specific biomarker for pathologic progress in diabetic microvascular complications?
Topics: Adult; Aged; Area Under Curve; Arginine; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Logistic Models; Lysine; Male; Middle Aged; Odds Ratio; Prediabetic State; ROC Curve; Tandem Mass Spectrometry | 2016 |
Intercellular Adhesion Molecule and Endogenous NOS Inhibitor: Asymmetric Dimethylarginine in Pregnant Women with Gestational Diabetes Mellitus.
Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Diabetes, Gestational; Enzyme-Linked Immunosorbent Assay; Female; Humans; Intercellular Adhesion Molecule-1; Pregnancy; Young Adult | 2016 |
Soluble receptor and gene polymorphism for AGE: relationship with obesity and cardiovascular risks.
Topics: Adolescent; Alleles; Arginine; Atherosclerosis; Biomarkers; Blood Pressure; Cardiovascular Diseases; Carotid Intima-Media Thickness; Case-Control Studies; Cross-Sectional Studies; Female; Humans; Lipids; Male; Pediatric Obesity; Polymorphism, Genetic; Receptor for Advanced Glycation End Products; Regression Analysis; Risk Factors | 2016 |
Asymmetric dimethylarginine (ADMA) treatment induces apoptosis in cultured rat mesangial cells via endoplasmic reticulum stress activation.
Topics: Animals; Apoptosis; Arginine; Caspase 3; Cell Line, Tumor; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Membrane Potential, Mitochondrial; Membrane Proteins; Mesangial Cells; Protein Serine-Threonine Kinases; Rats; Signal Transduction; Stress, Physiological | 2016 |
DDAH1 plays dual roles in PM2.5 induced cell death in A549 cells.
Topics: A549 Cells; Amidohydrolases; Arginine; Cell Death; Gene Expression Regulation; Humans; Mitogen-Activated Protein Kinases; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Oxidative Stress; Particle Size; Particulate Matter; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction | 2016 |
Relationship between FEV
Topics: Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Endothelium, Vascular; Female; Forced Expiratory Volume; Humans; Inflammation; Interleukin-6; Italy; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Risk Factors; Statistics as Topic; Vascular Stiffness | 2017 |
Association between Body Mass Index, Asymmetric Dimethylarginine and Risk of Cardiovascular Events and Mortality in Norwegian Patients with Suspected Stable Angina Pectoris.
Topics: Angina, Stable; Arginine; Body Mass Index; Female; Humans; Male; Middle Aged; Myocardial Infarction; Nitrogen Oxides; Norway; Risk Factors | 2016 |
Relevance of uric acid and asymmetric dimethylarginine for modeling cardiovascular risk prediction in chronic kidney disease patients.
Topics: Academic Medical Centers; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Cause of Death; Cohort Studies; Female; Humans; Kaplan-Meier Estimate; Kidney Failure, Chronic; Kidney Function Tests; Male; Middle Aged; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Assessment; Severity of Illness Index; Survival Analysis; Uric Acid | 2016 |
The "Rise-Peak-Fall" Pattern of Time Dependency of the Cardiovascular Pleiotropic Effects of Treatment With Low-dose Atorvastatin, Losartan, and a Combination Thereof in Rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Arginine; Atorvastatin; Cardiovascular System; Carrier Proteins; CD40 Antigens; Coronary Circulation; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isolated Heart Preparation; Losartan; Male; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Rats, Wistar; Time Factors; Vasodilation | 2016 |
Are increased oxidative stress and asymmetric dimethylarginine levels associated with masked hypertension?
Topics: Adult; Age Factors; Antioxidants; Arginine; Blood Pressure; Blood Pressure Determination; Body Mass Index; Female; Humans; Lipoproteins, LDL; Male; Masked Hypertension; Middle Aged; Oxidants; Oxidative Stress; Predictive Value of Tests; Risk Factors; Statistics as Topic | 2016 |
Osteoprotegerin, RANKL, ADMA, and Fetuin-A serum levels in children with type I diabetes mellitus.
Topics: Adolescent; alpha-2-HS-Glycoprotein; Arginine; Biomarkers; Cardiovascular Diseases; Child; Cohort Studies; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Cardiomyopathies; Enzyme-Linked Immunosorbent Assay; Female; Glycated Hemoglobin; Greece; Humans; Male; Osteoprotegerin; RANK Ligand; Reproducibility of Results | 2017 |
An asymmetrically dimethylarginated nuclear 90 kDa protein (p90aDMA) induced by interleukin (IL)-2, IL-4 or IL-6 in the tumor microenvironment is selectively degraded by autophagy.
Topics: Arginine; Autophagy; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Interleukin-2; Interleukin-4; Interleukin-6; MCF-7 Cells; Molecular Weight; Nuclear Proteins; Protein Processing, Post-Translational; Sirolimus; Tumor Microenvironment; Uterine Cervical Neoplasms | 2016 |
Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency.
Topics: Adolescent; Adult; Amino Acids; Arginase; Arginine; Case-Control Studies; Child; Child, Preschool; Female; Glycine; Humans; Infant; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Phenotype; Retrospective Studies; Urea Cycle Disorders, Inborn; Young Adult | 2016 |
(-)-Epigallocatechin Gallate Inhibits Asymmetric Dimethylarginine-Induced Injury in Human Brain Microvascular Endothelial Cells.
Topics: Antioxidants; Apoptosis; Arginine; Brain; Catechin; Cell Survival; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Microvessels | 2016 |
Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNFα/NF-κB response.
Topics: Animals; Arginine; Cell Line; Humans; Methylation; Mice; Mice, Knockout; Molecular Dynamics Simulation; NF-kappa B p50 Subunit; Protein-Arginine N-Methyltransferases; Repressor Proteins; Signal Transduction; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2016 |
Serum levels of homocysteine, asymmetric dimethylarginine and nitric oxide in patients with Parkinson's disease.
Topics: Aged; Arginine; Female; Homocysteine; Humans; Hyperhomocysteinemia; Immunoassay; Male; Middle Aged; Nitric Oxide; Parkinson Disease | 2016 |
Plasma concentrations of three methylated arginines, endogenous nitric oxide synthase inhibitors, in schizophrenic patients undergoing antipsychotic drug treatment.
Topics: Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Arginine; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; omega-N-Methylarginine; Schizophrenia; Treatment Outcome; Young Adult | 2016 |
The hydrogen sulfide releasing compounds ATB-346 and diallyl trisulfide attenuate streptozotocin-induced cognitive impairment, neuroinflammation, and oxidative stress in rats: involvement of asymmetric dimethylarginine.
Topics: Allyl Compounds; Animals; Arginine; Cognitive Dysfunction; Hydrogen Sulfide; Inflammation; Inflammation Mediators; Male; Maze Learning; Naproxen; Oxidative Stress; Rats; Rats, Wistar; Streptozocin; Sulfides | 2016 |
Asymmetric Dimethylarginine versus Proton Pump Inhibitors Usage in Patients with Stable Coronary Artery Disease: A Cross-Sectional Study.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Arginine; Coronary Artery Disease; Cross-Sectional Studies; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Humans; Male; Middle Aged; Omeprazole; Pantoprazole; Peptic Ulcer; Proton Pump Inhibitors; Treatment Outcome | 2016 |
Increased Asymmetric Dimethylarginine and Ischemia-Modified Albumin Levels in Obstructive Sleep Apnea.
Topics: Adult; Arginine; Biomarkers; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Polysomnography; Serum Albumin; Serum Albumin, Human; Severity of Illness Index; Sleep Apnea, Obstructive | 2016 |
Asymmetric dimethylarginine and heart-type fatty acid-binding protein 3 are risk markers of cardiotoxicity in carbon monoxide poisoning cases in Zagazig university hospitals.
Topics: Adult; Arginine; Biomarkers; Carbon Monoxide Poisoning; Carboxyhemoglobin; Case-Control Studies; Egypt; Electrocardiography; Fatty Acid Binding Protein 3; Fatty Acid-Binding Proteins; Female; Heart; Humans; Male; Risk Factors; Young Adult | 2017 |
Detrimental effects of a bout of physical exercise on circulating endogenous inhibitors of endothelial function in patients with coronary artery disease.
Topics: Adult; Aged; Arginine; Biomarkers; Case-Control Studies; Coronary Artery Disease; Echocardiography; Exercise; Exercise Test; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Risk Factors; Young Adult | 2017 |
High salt medium activates RhoA/ROCK and downregulates eNOS expression via the upregulation of ADMA.
Topics: Arginine; Cell Line; Cell Survival; Cells, Cultured; Gene Expression; Gene Expression Regulation; Humans; Nitric Oxide Synthase Type III; Protein-Arginine N-Methyltransferases; Repressor Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA Interference; RNA, Messenger; RNA, Small Interfering; Sodium Chloride, Dietary | 2016 |
NO synthesis from arginine is favored by α-linolenic acid in mice fed a high-fat diet.
Topics: alpha-Linolenic Acid; Animals; Arginine; Dietary Fats; Liver; Male; Mice; Nitric Oxide; PPAR alpha; Signal Transduction | 2016 |
Effects of ADMA on gene expression and metabolism in serum-starved LoVo cells.
Topics: Apoptosis; Arginine; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Culture Media; Fatty Acids; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Male; Metabolome; Metabolomics; Nucleic Acids; Oligonucleotide Array Sequence Analysis | 2016 |
Determination of Asymmetric and Symmetric Dimethylarginine in Serum from Patients with Chronic Kidney Disease: UPLC-MS/MS versus ELISA.
Topics: Arginine; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Humans; Renal Insufficiency, Chronic; Tandem Mass Spectrometry | 2016 |
Oncological miR-182-3p, a Novel Smooth Muscle Cell Phenotype Modulator, Evidences From Model Rats and Patients.
Topics: Animals; Arginine; Carotid Artery Diseases; Carotid Artery Injuries; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Coronary Artery Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Gene Expression Profiling; Gene Expression Regulation; Humans; Male; MicroRNAs; Muscle, Smooth, Vascular; Myelin and Lymphocyte-Associated Proteolipid Proteins; Myocytes, Smooth Muscle; Neointima; Oligonucleotide Array Sequence Analysis; Phenotype; Rats, Sprague-Dawley; RNA Interference; Signal Transduction; Transfection; Vascular Remodeling | 2016 |
High Levels of Methylarginines Were Associated With Increased Mortality in Patients With Severe Sepsis.
Topics: Aged; Arginine; Female; Humans; Male; Middle Aged; Nitric Oxide; Proportional Hazards Models; Sepsis; Shock, Septic | 2016 |
Serum L-arginine and dimethylarginine levels in migraine patients with brain white matter lesions.
Topics: Adult; Aged; Arginine; Biomarkers; Female; Humans; Male; Middle Aged; Migraine Disorders; White Matter; Young Adult | 2017 |
Asymmetric dimethylarginine and related metabolites in exhaled breath condensate of children with cystic fibrosis.
Topics: Adolescent; Arginine; Biomarkers; Breath Tests; Child; Chromatography, High Pressure Liquid; Cystic Fibrosis; Disease Progression; Exhalation; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Mass Spectrometry; Prospective Studies | 2018 |
Comparison of Asymmetric Dimethylarginine Levels Between Stages Three, Four, and Five Non-dialysis of Chronic Kidney Disease.
Topics: Adult; Arginine; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Renal Insufficiency, Chronic | 2016 |
Early regression of coronary artery remodeling with esmolol and DDAH/ADMA pathway in hypertensive rats.
Topics: Adrenergic beta-1 Receptor Antagonists; Amidohydrolases; Animals; Arginine; Blood Pressure; Coronary Vessels; Dose-Response Relationship, Drug; Hypertension; Male; Myocytes, Smooth Muscle; Nitric Oxide; Propanolamines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Serotonin; Vascular Remodeling | 2016 |
N-Acetylcysteine Prevents Programmed Hypertension in Male Rat Offspring Born to Suramin-Treated Mothers.
Topics: Acetylcysteine; Animals; Arginine; Blood Pressure; Female; Fetal Development; Hydrogen Sulfide; Hypertension; Kidney; Male; Nitric Oxide; Pre-Eclampsia; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Suramin | 2016 |
Asymmetric dimethylarginine, related arginine derivatives, and incident atrial fibrillation.
Topics: Aged; Arginine; Atrial Fibrillation; Biomarkers; Cohort Studies; Female; Humans; Incidence; Male; Middle Aged; Oxidative Stress; Proportional Hazards Models; Reproducibility of Results; Statistics as Topic | 2016 |
Endothelin 1, ADMA and SDMA in pregnancies with obstetric and thrombotic antiphospholipid syndrome.
Topics: Adult; Antiphospholipid Syndrome; Arginine; Chronic Disease; Endothelin-1; Endothelium, Vascular; Female; Humans; Hypertension; Pre-Eclampsia; Pregnancy; Prognosis; Thrombosis; Young Adult | 2016 |
Increased ADMA levels are associated with poor pulmonary outcome in preterm neonates.
Topics: Arginine; Biomarkers; Birth Weight; Bronchopulmonary Dysplasia; Female; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Male; Prognosis; Pulmonary Surfactants; Respiration, Artificial; Respiratory Distress Syndrome, Newborn | 2017 |
Elevated parathyroid hormone predicts high asymmetric dimethylarginine (ADMA) concentrations in obese diabetic patients.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Diabetes Mellitus; Female; Humans; Linear Models; Male; Middle Aged; Obesity; Parathyroid Hormone | 2016 |
Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension?
Topics: Altitude Sickness; Amidohydrolases; Animals; Arginine; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Lung; Male; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Pulmonary Circulation; Rats; Rats, Wistar; Signal Transduction; Time Factors; Vascular Resistance | 2016 |
Hypoxia causes increased monocyte nitric oxide synthesis which is mediated by changes in dimethylarginine dimethylaminohydrolase 2 expression in animal and human models of normobaric hypoxia.
Topics: Adolescent; Adult; Amidohydrolases; Animals; Arginine; Cell Hypoxia; Humans; Hypoxia; Macrophages, Peritoneal; Male; Mice, Knockout; Middle Aged; Monocytes; Nitrates; Nitric Oxide; Nitrites; Young Adult | 2016 |
Upregulation of CBS/H2S system contributes to asymmetric dimethylarginine-triggered protection against the neurotoxicity of glutamate to PC12 cells by inhibiting NOS/NO pathway.
Topics: Animals; Arginine; Cystathionine beta-Synthase; Glutamic Acid; Hydrogen Sulfide; Neuroprotection; Neuroprotective Agents; Neurotoxins; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; PC12 Cells; Rats; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Up-Regulation | 2016 |
Elevated plasma ADMA contributes to development of endothelial dysfunction in children with acute lymphoblastic leukemia.
Topics: Adolescent; Arginine; Cardiovascular Diseases; Child; Child, Preschool; Endothelial Cells; Endothelium-Dependent Relaxing Factors; Enzyme Inhibitors; Female; Humans; Infant; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors | 2016 |
MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters.
Topics: Amino Acid Transport Systems, Basic; Animals; Arginine; Choline; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Male; Methionine; Rats; Rats, Wistar | 2016 |
ASYMMETRIC DIMETHYLARGININE LEVELS AND ATHEROSCLEROSIS MARKERS IN CUSHING SYNDROME.
Topics: Adult; Ankle Brachial Index; Arginine; Atherosclerosis; Biomarkers; C-Reactive Protein; Carotid Intima-Media Thickness; Case-Control Studies; Cushing Syndrome; Female; Humans; Male; Middle Aged; Risk Factors | 2016 |
Relationship of asymmetric dimethylarginine (ADMA) with extent and functional severity of coronary atherosclerosis.
Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Coronary Angiography; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Severity of Illness Index | 2016 |
Serum asymmetric dimethylarginine and arginine levels predict microvascular and macrovascular complications in type 2 diabetes mellitus.
Topics: Adolescent; Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Humans; Male; Middle Aged; Oxidative Stress; Prognosis; Prospective Studies; Risk Factors; Young Adult | 2017 |
Asymmetric dimethylarginine (ADMA): will be or will not be a new revolutionary biomarker of bronchial asthma?
Topics: Adult; Arginine; Asthma; Biomarkers; Case-Control Studies; Child; Enzyme Inhibitors; Evidence-Based Medicine; Exhalation; Humans; Phenotype; Predictive Value of Tests; Sensitivity and Specificity; Severity of Illness Index; Spirometry | 2015 |
The transporter and permeability interactions of asymmetric dimethylarginine (ADMA) and L-arginine with the human blood-brain barrier in vitro.
Topics: Arginine; Blood-Brain Barrier; Cationic Amino Acid Transporter 1; Cell Line; Cell Survival; Enzyme Inhibitors; Humans; In Vitro Techniques; Interferon-gamma; Nitric Oxide; Ornithine; Permeability; Reactive Oxygen Species; Sucrose; Tumor Necrosis Factor-alpha | 2016 |
Effect of cholesterol lowering treatment on plasma markers of endothelial dysfunction in chronic kidney disease.
Topics: Allantoin; Anticholesteremic Agents; Arginine; Biomarkers; Cholesterol; Endothelium; Ezetimibe; Female; Humans; Inflammation; Kynurenine; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Renal Insufficiency, Chronic; Simvastatin; Uric Acid | 2016 |
[Effect of asymmetrical dimethylarginine for predicting pro-thrombotic risk in atrial fibrillation].
Topics: Arginine; Atrial Fibrillation; Cardiovascular Diseases; Heart Atria; Humans; Stereoisomerism; Thrombosis | 2016 |
Vascular peroxidase 1 up regulation by angiotensin II attenuates nitric oxide production through increasing asymmetrical dimethylarginine in HUVECs.
Topics: Amidohydrolases; Angiotensin II; Animals; Aorta; Arginine; Cells, Cultured; Endothelium, Vascular; Gene Knockdown Techniques; Hemeproteins; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Peroxide; Hypertension; Hypochlorous Acid; Male; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxidases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Recombinant Proteins; RNA, Small Interfering; Up-Regulation | 2016 |
Arginines Plasma Concentration and Oxidative Stress in Mild to Moderate COPD.
Topics: Age Factors; Aged; Aged, 80 and over; Arginine; Aryldialkylphosphatase; Biomarkers; Case-Control Studies; Female; Forced Expiratory Volume; Humans; Linear Models; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Severity of Illness Index; Sex Factors; Taurine | 2016 |
Endothelial Nitric Oxide Synthase Prevents Heparanase Induction and the Development of Proteinuria.
Topics: Albumins; Animals; Arginine; Doxorubicin; Enzyme Induction; Gene Expression Regulation, Enzymologic; Glucuronidase; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type III; Proteinuria | 2016 |
Marker of Endothelial Dysfunction Asymmetric Dimethylarginine Is Elevated in HIV Infection but Not Associated With Subclinical Atherosclerosis.
Topics: Adult; Arginine; Atherosclerosis; Biomarkers; Cross-Sectional Studies; Endothelial Cells; Female; HIV Infections; Humans; Lipopolysaccharide Receptors; Male; Middle Aged; Plasma | 2016 |
The correlation of serum asymmetric dimethylarginine and anti-Müllerian hormone in primary dysmenorrhea.
Topics: Anti-Mullerian Hormone; Arginine; Demography; Dysmenorrhea; Female; Humans; Linear Models; Pain Measurement; Young Adult | 2016 |
Asymmetrical dimethyl arginine in type 2 diabetic patients with coronary artery disease.
Topics: Adult; Arginine; Blood Glucose; Case-Control Studies; Coronary Artery Disease; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged; Triglycerides | 2016 |
Risk factors for chronic kidney disease do not influence the serum levels of asymmetric dimethylarginine in HIV-1-infected patients without significant renal disease.
Topics: Adult; Aged; Anti-HIV Agents; Arginine; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Renal Insufficiency, Chronic; Risk Factors; Young Adult | 2016 |
Increased Bronchial Hyperresponsiveness and Higher Asymmetric Dimethylarginine Levels after Fetal Growth Restriction.
Topics: Anthropometry; Arginine; Biomarkers; Bronchial Hyperreactivity; Child; Demography; Female; Fetal Growth Retardation; Humans; Infant, Newborn; Inflammation Mediators; Lung; Male; Methacholine Chloride; Premature Birth; Respiratory Function Tests; Solubility | 2017 |
Prediction of pre-eclampsia combining NGAL and other biochemical markers with Doppler in the first and/or second trimester of pregnancy. A pilot study.
Topics: Adult; Arginine; Biomarkers; Female; Humans; Lipocalin-2; Matrix Metalloproteinase 9; Pilot Projects; Placenta Growth Factor; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Pregnancy-Associated Plasma Protein-A; Ultrasonography, Doppler, Pulsed; Vascular Endothelial Growth Factor Receptor-1 | 2016 |
Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis.
Topics: Animals; Arginine; Cyclooxygenase 2; Drug Combinations; Endothelium; Enzyme Inhibitors; Humans; Ibuprofen; Kidney; Male; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Substrate Specificity | 2016 |
Short-term esmolol attenuates remodeling of the thoracic aorta in hypertensive rats by decreasing concentrations of ADMA down-regulated by oxidative stress.
Topics: Animals; Aorta, Thoracic; Arginine; Blood Pressure; Down-Regulation; Heart Rate; Male; Oxidative Stress; Propanolamines; Protein Carbonylation; Rats; Rats, Inbred SHR; Tensile Strength; Vascular Remodeling | 2016 |
Modulation of circulating endothelial progenitor cells by erythropoiesis-stimulating agents in patients with chronic kidney disease stage G5 and 5D
.
Topics: Adult; Arginine; Biomarkers; C-Reactive Protein; Cell Count; Darbepoetin alfa; Endothelial Progenitor Cells; Erythropoietin; Female; Hematinics; Humans; Kidney Failure, Chronic; Male; Matrix Metalloproteinase 2; Middle Aged; Prospective Studies; Recombinant Proteins; Renal Dialysis; Vascular Endothelial Growth Factor A | 2016 |
The prediction roles of asymmetric dimethyl-arginine, adiponectin and apelin for macroangiopathy in patients with impaired glucose regulation.
Topics: Adiponectin; Aged; Apelin; Arginine; Atherosclerosis; Blood Glucose; Coronary Disease; Female; Glucose Intolerance; Glucose Tolerance Test; Humans; Insulin Resistance; Intercellular Signaling Peptides and Proteins; Male; Middle Aged; Prediabetic State; Prognosis | 2016 |
Asymmetric dimethylarginine: a risk indicator or pathogenic factor?
Topics: Arginine; HIV Infections; HIV-1; Humans; Renal Insufficiency, Chronic | 2016 |
Nebivolol suppresses asymmetric dimethylarginine and attenuates cyclosporine-induced nephrotoxicity and endothelial dysfunction in rats.
Topics: Acute Kidney Injury; Adrenergic beta-1 Receptor Agonists; Animals; Arginine; Cyclosporine; Dose-Response Relationship, Drug; Endothelium, Vascular; Immunosuppressive Agents; Male; Nebivolol; Nitric Oxide Synthase Type II; Organ Culture Techniques; Oxidative Stress; Rats; Rats, Wistar | 2016 |
Asymmetric dimethylarginine predicts the risk of contrast-induced acute kidney injury in patients undergoing cardiac catheterization.
Topics: Acute Kidney Injury; Aged; Arginine; Cardiac Catheterization; Contrast Media; Coronary Angiography; Female; Humans; Male; Middle Aged; Nitric Oxide; Prospective Studies; Risk Factors; ROC Curve | 2016 |
Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2.
Topics: Aminoisobutyric Acids; Animals; Arginine; Cardiovascular Diseases; Cell Line; Diabetes Mellitus, Type 2; Gene Expression Regulation; Hepatocyte Nuclear Factor 4; Humans; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Risk; RNA, Small Interfering; Transaminases | 2016 |
Increased plasma asymmetric dimethylarginine is associated with cognitive deficits in patients with schizophrenia.
Topics: Adult; Arginine; Biomarkers; Cognition Disorders; Cognitive Dysfunction; Female; Humans; Male; Neuropsychological Tests; Schizophrenia; Young Adult | 2016 |
Higher serum asymmetric dimethylarginine is related to higher risk of heart failure in the EPIC-Potsdam study.
Topics: Adult; Aged; Arginine; Biomarkers; Feeding Behavior; Female; Germany; Heart Failure; Humans; Male; Middle Aged; Myocardial Infarction; Prognosis; Proportional Hazards Models; Prospective Studies; Risk | 2017 |
12-months metabolic changes among gender dysphoric individuals under cross-sex hormone treatment: a targeted metabolomics study.
Topics: Adult; Amino Acids; Anthropometry; Arginine; Body Composition; Energy Metabolism; Fasting; Female; Gender Dysphoria; Gonadal Steroid Hormones; Humans; Lipid Metabolism; Male; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Principal Component Analysis; Sex Characteristics; Sex Reassignment Procedures | 2016 |
l-Arginine Pathway Metabolites Predict Need for Intra-operative Shunt During Carotid Endarterectomy.
Topics: Aged; Anaerobiosis; Area Under Curve; Arginine; Biomarkers; Blood Gas Analysis; Blood-Brain Barrier; Capillary Permeability; Carotid Stenosis; Cerebrovascular Circulation; Constriction; Endarterectomy, Carotid; Female; Humans; Jugular Veins; Lactic Acid; Male; Middle Aged; Pilot Projects; Predictive Value of Tests; Prospective Studies; Radial Artery; Reproducibility of Results; Risk Factors; ROC Curve; S100 Calcium Binding Protein beta Subunit; Time Factors; Treatment Outcome | 2016 |
Increased serum concentrations of asymmetric dimethylarginine (ADMA) in patients with early-onset coronary artery disease.
Topics: Age of Onset; Arginine; Coronary Artery Disease; Coronary Vessels; Female; Humans; Male; Middle Aged; Risk | 2017 |
Effect of l-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine on ischemic heart disease risk: A Mendelian randomization study.
Topics: Arginine; Female; Genome-Wide Association Study; Humans; Male; Mediator Complex; Mendelian Randomization Analysis; Myocardial Infarction; Polymorphism, Single Nucleotide; Transaminases | 2016 |
Endocan, TGF-beta, and ADMA as Risk Factors for Endothelial Dysfunction and Possible Vascular Disease in Patients with Subclinical Hypothyroidism.
Topics: Adult; Arginine; Biomarkers; Demography; Endothelium, Vascular; Female; Humans; Hypothyroidism; Inflammation; Male; Neoplasm Proteins; Proteoglycans; Risk Factors; Thyroid Function Tests; Transforming Growth Factor beta; Vascular Diseases | 2016 |
Plasma Apelin and Asymmetric Dimethylarginine (ADMA) Levels Shortly After Laparoscopic Greater Curvature Plication.
Topics: Adolescent; Adult; Apelin; Arginine; Bariatric Surgery; Female; Humans; Laparoscopy; Male; Middle Aged; Obesity, Morbid; Young Adult | 2017 |
Protective effect of tanshinone IIA against cardiac hypertrophy in spontaneously hypertensive rats through inhibiting the Cys-C/Wnt signaling pathway.
Topics: Abietanes; Animals; Arginine; Cardiomegaly; Cardiovascular Agents; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type III; Cystatin C; Disease Models, Animal; Hypertension; Male; Myocardium; NADPH Oxidase 4; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Troponin I; Wnt Signaling Pathway | 2017 |
Evaluation of endothelial dysfunction in patients with familial Mediterranean fever: the relationship between the levels of asymmetric dimethylarginine and endocan with carotid intima-media thickness and endothelium-dependent vasodilation.
Topics: Adult; Arginine; Atherosclerosis; Biomarkers; Carotid Intima-Media Thickness; Case-Control Studies; Endothelium, Vascular; Familial Mediterranean Fever; Female; Humans; Inflammation; Male; Neoplasm Proteins; Proteoglycans; ROC Curve; Turkey; Vasodilation; Young Adult | 2017 |
Endothelial dysfunction in the early postoperative period after major colon cancer surgery.
Topics: Aged; Arginine; Colonic Neoplasms; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Nitric Oxide; Postoperative Complications; Prospective Studies; Troponin I | 2017 |
Involvement of DDAH/ADMA/NOS/cGMP and COX-2/PTGIS/cAMP Pathways in Human Tissue Kallikrein 1 Protecting Erectile Function in Aged Rats.
Topics: Aging; Amidohydrolases; Animals; Arginine; Cyclic AMP; Cyclic GMP; Cyclooxygenase 2; Cytochrome P-450 Enzyme System; Erectile Dysfunction; Humans; Intramolecular Oxidoreductases; Male; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Penile Erection; Penis; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Recombinant Proteins; RNA, Messenger; Signal Transduction; Tissue Kallikreins | 2017 |
Admission levels of asymmetric and symmetric dimethylarginine predict long-term outcome in patients with community-acquired pneumonia.
Topics: Adult; Aged; Arginine; Biomarkers; Community-Acquired Infections; Female; Humans; Longitudinal Studies; Male; Middle Aged; Patient Admission; Pneumonia; Prevalence; Proportional Hazards Models; Risk Assessment; Risk Factors; Survival Analysis; Switzerland | 2017 |
Increased brachial intima-media thickness is associated with circulating levels of asymmetric dimethylarginine in patients with COPD.
Topics: Aged; Arginine; Asymptomatic Diseases; Atherosclerosis; Biomarkers; Brachial Artery; Case-Control Studies; Female; Humans; Inflammation; Inflammation Mediators; Linear Models; Lung; Male; Middle Aged; Multivariate Analysis; Prognosis; Pulmonary Disease, Chronic Obstructive; Risk Assessment; Risk Factors; Sex Factors; Smoking; Spirometry; Tunica Intima; Tunica Media; Ultrasonography | 2017 |
Investigation of Asymmetric and Symmetric Dimethylarginine Levels after Iloprost Treatment in Patients with Buerger's Disease.
Topics: Adult; Aged; Arginine; Biomarkers; Female; Humans; Iloprost; Infusions, Intravenous; Male; Middle Aged; Thromboangiitis Obliterans; Time Factors; Treatment Outcome; Vasodilator Agents | 2017 |
Repetitive ischemia increases myocardial dimethylarginine dimethylaminohydrolase 1 expression.
Topics: Amidohydrolases; Animals; Arginine; Cell Hypoxia; Cells, Cultured; Collateral Circulation; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Dogs; Endothelial Cells; Humans; Interleukin-1beta; Myocardial Ischemia; Myocardium; Neovascularization, Physiologic; Nitric Oxide Synthase Type II; Protein-Arginine N-Methyltransferases; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor A | 2017 |
Preservation of vascular DDAH activity contributes to the protection of captopril against endothelial dysfunction in hyperlipidemic rabbits.
Topics: Amidohydrolases; Animals; Arginine; Captopril; Diet, High-Fat; Endothelium, Vascular; Enzyme Inhibitors; Hyperlipidemias; Male; Rabbits | 2017 |
DdaR (PA1196) Regulates Expression of Dimethylarginine Dimethylaminohydrolase for the Metabolism of Methylarginines in Pseudomonas aeruginosa PAO1.
Topics: Amidohydrolases; Arginine; Bacterial Proteins; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; omega-N-Methylarginine; Pseudomonas aeruginosa; RNA Polymerase Sigma 54 | 2017 |
ADMA predicts major adverse renal events in patients with mild renal impairment and/or diabetes mellitus undergoing coronary angiography.
Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Contrast Media; Coronary Angiography; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Predictive Value of Tests; Proportional Hazards Models; Renal Insufficiency; Severity of Illness Index | 2017 |
Carotid Plaque Score and Risk of Cardiovascular Mortality in the Oldest Old: Results from the TOOTH Study.
Topics: Aged; Aged, 80 and over; Aging; Arginine; Cardiovascular Diseases; Carotid Stenosis; Cohort Studies; Female; Humans; Japan; Kaplan-Meier Estimate; Male; Multivariate Analysis; Proportional Hazards Models; Risk Factors; Sensitivity and Specificity; Treatment Outcome | 2018 |
[Clinical value of ADMA in patients with pulmonary arterial hypertension combination with congenital heart disease].
Topics: Adult; Arginine; Biomarkers; Echocardiography; Female; Heart Defects, Congenital; Hemodynamics; Humans; Hypertension, Pulmonary; Male; Prognosis; Sensitivity and Specificity; Sildenafil Citrate | 2017 |
Asymmetric dimethylarginine in the assessment of febrile neutropenia in hematological patients.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Arginine; Bacteremia; Biomarkers; C-Reactive Protein; Febrile Neutropenia; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Prospective Studies; Shock, Septic; Stem Cell Transplantation; Transplantation, Autologous | 2017 |
Metabolic profiling of presymptomatic Huntington's disease sheep reveals novel biomarkers.
Topics: Amino Acids, Branched-Chain; Animals; Animals, Genetically Modified; Area Under Curve; Arginine; Biomarkers; Citrulline; Genotype; Huntington Disease; Logistic Models; Metabolomics; ROC Curve; Sheep | 2017 |
Analysis of risk factors in patients with leukoaraiosis.
Topics: Age Factors; Aged; Arginine; Blood Chemical Analysis; Enzyme-Linked Immunosorbent Assay; Factor Analysis, Statistical; Female; Humans; Leukoaraiosis; Logistic Models; Male; Middle Aged; Risk Factors | 2017 |
The role of L-arginine/L-homoarginine/nitric oxide pathway for aortic distensibility and intima-media thickness in stroke patients.
Topics: Aorta; Arginine; Atherosclerosis; Endothelium, Vascular; Female; Homoarginine; Humans; Male; Middle Aged; Nitric Oxide; Stroke; Ultrasonography; Vascular Remodeling | 2017 |
Time-course changes of nLDL-induced erectile dysfunction.
Topics: Animals; Arginine; Disease Models, Animal; Endothelium, Vascular; Erectile Dysfunction; Hyperlipidemias; Lipoproteins, LDL; Male; Nitric Oxide Synthase Type III; Rats, Wistar; Time Factors | 2017 |
Myeloperoxidase, asymmetric dimethyl-arginine and the renin-angiotensin-aldosterone-system in cardiovascular risk patients: Cross-sectional findings from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study.
Topics: Aged; Aldosterone; Arginine; Austria; Biomarkers; Cardiovascular Diseases; Cohort Studies; Coronary Angiography; Cross-Sectional Studies; Female; Follow-Up Studies; Germany; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Male; Middle Aged; Mortality; Peroxidase; Predictive Value of Tests; Prevalence; Prospective Studies; Renin-Angiotensin System; Risk Factors | 2017 |
Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study.
Topics: Aged; Arginine; Cardiovascular Diseases; Case-Control Studies; Chromatography, Liquid; Citrulline; Cohort Studies; Female; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; omega-N-Methylarginine; Ornithine; Proportional Hazards Models; Prospective Studies; Risk Factors; Stroke; Tandem Mass Spectrometry | 2017 |
Positive correlation of airway resistance and serum asymmetric dimethylarginine level in COPD patients with systemic markers of low-grade inflammation.
Topics: Aged; Airway Resistance; Arginine; Biomarkers; Bronchodilator Agents; C-Reactive Protein; Chi-Square Distribution; Cross-Sectional Studies; Disease Progression; Female; Humans; Inflammation Mediators; Linear Models; Lung; Male; Maximal Midexpiratory Flow Rate; Middle Aged; Plethysmography, Whole Body; Pulmonary Disease, Chronic Obstructive; Surveys and Questionnaires | 2017 |
HIV-infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation.
Topics: Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; HIV Infections; Humans; Inflammation; Male; Methylamines; Middle Aged; Risk Factors; Tandem Mass Spectrometry | 2017 |
Asymmetric dimethylarginine and arginine metabolites in women with and without a history of gestational diabetes.
Topics: Adult; Arginine; Cardiovascular Diseases; Diabetes, Gestational; Female; Follow-Up Studies; Glucose Tolerance Test; Humans; Postpartum Period; Pregnancy; Prognosis | 2017 |
The asymmetric dimethylarginine-mediated inhibition of nitric oxide in the rostral ventrolateral medulla contributes to regulation of blood pressure in hypertensive rats.
Topics: Amidohydrolases; Angiotensin II; Animals; Arginine; Blood Pressure; Heart Rate; Kidney; Losartan; Male; Medulla Oblongata; Nitric Oxide; omega-N-Methylarginine; Protein-Arginine N-Methyltransferases; Rats, Inbred WKY; Rats, Sprague-Dawley; Sympathetic Nervous System | 2017 |
Effect of arginine:lysine and glycine:methionine intake ratios on dyslipidemia and selected biomarkers implicated in cardiovascular disease: A study with hypercholesterolemic rats.
Topics: Administration, Oral; Amino Acids; Animals; Arginine; Biomarkers; Body Weight; Cardiovascular Diseases; Dyslipidemias; Glycine; Homocysteine; Hypercholesterolemia; Lipids; Liver; Lysine; Male; Methionine; Nitric Oxide; Organ Size; Rats, Wistar | 2017 |
Association of circulatory asymmetric dimethylarginine (ADMA) with diabetic nephropathy in Asian Indians and its causative role in renal cell injury.
Topics: Adult; Albuminuria; Animals; Arginine; Asian People; Biomarkers; Cell Line; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Fibroblasts; Glomerular Mesangium; Glycated Hemoglobin; Humans; India; Male; Middle Aged; Rats | 2017 |
The ADMA/DDAH/NO pathway in human vein endothelial cells exposed to arsenite.
Topics: Amidohydrolases; Arginine; Arsenites; Cell Survival; Cells, Cultured; Human Umbilical Vein Endothelial Cells; Humans; NADPH Oxidase 4; Nitric Oxide; Oxidative Stress; Protein-Arginine N-Methyltransferases; Repressor Proteins | 2017 |
Regulation of c-Jun N-Terminal Protein Kinase (JNK) Pathway in Apoptosis of Endothelial Outgrowth Cells Induced by Asymmetric Dimethylarginine.
Topics: Anthracenes; Apoptosis; Arginine; Cell Proliferation; Cell Survival; Endothelial Cells; Flow Cytometry; Fluorescence; Humans; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Neovascularization, Physiologic; Phosphorylation; Protein Kinase Inhibitors; Staining and Labeling | 2017 |
Evaluation of ADMA, carbonyl groups, CAT and NKA in depressed patients with and without posttraumatic stress disorder.
Topics: Adult; Arginine; Biomarkers; Catalase; Depressive Disorder, Major; Female; Gene Expression Regulation; Humans; Male; Middle Aged; Neurokinin A; Stress Disorders, Post-Traumatic | 2017 |
Methionine metabolism and multiple sclerosis.
Topics: Adult; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Cysteine; Electrochemical Techniques; Female; Glutathione; Homocysteine; Humans; Male; Methionine; Middle Aged; Multiple Sclerosis | 2017 |
Human dimethylarginine dimethylaminohydrolase 1 inhibition by proton pump inhibitors and the cardiovascular risk marker asymmetric dimethylarginine: in vitro and in vivo significance.
Topics: Aged; Aged, 80 and over; Amidohydrolases; Arginine; Australia; Biomarkers; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Female; Humans; Male; Mass Spectrometry; Middle Aged; Proton Pump Inhibitors; Risk Assessment | 2017 |
Asymmetric Dimethylarginine Induced Apoptosis and Dysfunction of Endothelial Progenitor Cells: Role of Endoplasmic Reticulum Stress Pathway.
Topics: Apoptosis; Arginine; Cells, Cultured; eIF-2 Kinase; Endoplasmic Reticulum Stress; Endothelial Progenitor Cells; Humans; Phosphorylation; Transcription Factor CHOP | 2017 |
Association of the -449GC and -1151AC polymorphisms in the DDAH2 gene with asymmetric dimethylarginine and erythropoietin resistance in Chinese patients on maintenance hemodialysis.
Topics: Alleles; Amidohydrolases; Arginine; Asian People; Erythropoietin; Female; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Renal Dialysis | 2017 |
Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice.
Topics: Aging; Aldosterone; Amidohydrolases; Animals; Arginine; Cell Line; Creatinine; Diabetes Mellitus, Experimental; Disease Models, Animal; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibrosis; Gene Knockout Techniques; Humans; Kidney Diseases; Kidney Tubules, Proximal; Mice | 2017 |
Effect of Visible Light on Vasospasticity of Post-Subarachnoid Hemorrhage Cerebrospinal Fluid.
Topics: Animals; Arginine; Bilirubin; Female; Humans; Light; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oxidation-Reduction; Rats; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2017 |
Asymmetric Dimethylarginine Contributes to the Impaired Response to Erythropoietin in CKD-Anemia.
Topics: Aged; Amidohydrolases; Anemia; Animals; Arginine; Cytokines; Drug Resistance; Erythrocyte Indices; Erythrocytes; Erythropoietin; Female; Gene Expression; Hematinics; Hematocrit; Hemoglobins; Humans; Male; Mice; Middle Aged; Muscle Proteins; Nephrectomy; Plasma; Receptors, Erythropoietin; Renal Insufficiency, Chronic | 2017 |
Paraoxonase-1 and myeloperoxidase correlate with vascular biomarkers in overweight patients with newly diagnosed untreated hyperlipidaemia.
Topics: Adult; Aged; Arginine; Aryldialkylphosphatase; Biomarkers; C-Reactive Protein; Case-Control Studies; CD40 Ligand; Female; Humans; Hyperlipidemias; Intercellular Adhesion Molecule-1; Lipoproteins, LDL; Male; Middle Aged; Overweight; Peroxidase; Predictive Value of Tests; Vascular Cell Adhesion Molecule-1 | 2017 |
Association between vitamin D status and asymmetric dimethylarginine (ADMA) concentration in the Korean elderly population.
Topics: Aged; Aged, 80 and over; Arginine; Asian People; Biomarkers; Cardiovascular Diseases; Cross-Sectional Studies; Female; Humans; Longitudinal Studies; Male; Middle Aged; Vitamin D; Vitamin D Deficiency | 2017 |
Renalase Assessment With Regard to Kidney Function, Lipid Disturbances, and Endothelial Dysfunction Parameters in Stable Renal Transplant Recipients.
Topics: Adult; Antihypertensive Agents; Arginine; C-Reactive Protein; Case-Control Studies; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Creatinine; Cross-Sectional Studies; Endothelium, Vascular; Female; Glomerular Filtration Rate; Hemoglobins; Humans; Hypertension; Intercellular Adhesion Molecule-1; Kidney Transplantation; Male; Middle Aged; Monoamine Oxidase; Renal Insufficiency, Chronic; Severity of Illness Index; Vascular Cell Adhesion Molecule-1 | 2017 |
Energy regulation in newly diagnosed TB with chronic energy deficiency: free fatty acids and RBP4.
Topics: Adolescent; Adult; Arginine; Body Mass Index; Cross-Sectional Studies; Energy Metabolism; Fatty Acids, Nonesterified; Female; Humans; Male; Malnutrition; Middle Aged; Retinol-Binding Proteins, Plasma; Tuberculosis; Young Adult | 2017 |
Importance of endothelial dysfunction biomarkers in patients with Crimean-Congo hemorrhagic fever.
Topics: Adult; Aged; Arginine; Biomarkers; Cytokines; Endothelin-1; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Hemorrhage; Hemorrhagic Fever Virus, Crimean-Congo; Hemorrhagic Fever, Crimean; Humans; Kinetics; Male; Middle Aged; Prognosis; Prospective Studies; ROC Curve; Thrombomodulin; Turkey; von Willebrand Factor | 2017 |
The prognostic biomarker L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B.
Topics: Amino Acid Transport Systems, Basic; Arginine; Biological Transport, Active; Cationic Amino Acid Transporter 1; Gene Expression; HEK293 Cells; Homoarginine; Humans; Kinetics; Protein Isoforms; Substrate Specificity; Transgenes | 2017 |
Physical activity - related changes in ADMA and vWF levels in patients with type 2 diabetes: A preliminary study.
Topics: Adult; Arginine; Cholesterol, HDL; Diabetes Mellitus, Type 2; Exercise; Female; Humans; Male; Middle Aged; von Willebrand Factor | 2017 |
Metabolism and distribution of pharmacological homoarginine in plasma and main organs of the anesthetized rat.
Topics: Amidinotransferases; Animals; Arginine; Glycine; Guanidinoacetate N-Methyltransferase; Half-Life; Homoarginine; Humans; Kidney; Lipid Peroxidation; Malondialdehyde; Models, Animal; Nitric Oxide Synthase; Pilot Projects; Rats; Rats, Sprague-Dawley; Takotsubo Cardiomyopathy; Tissue Distribution | 2017 |
Increased plasma asymmetric dimethylarginine level is associated with ascending aorta dilatation: a case-control study.
Topics: Aged; Aorta; Aortic Diseases; Arginine; Case-Control Studies; Cross-Sectional Studies; Dilatation, Pathologic; Female; Humans; Male; Middle Aged; ROC Curve | 2017 |
A new key player in VEGF-dependent angiogenesis in human hepatocellular carcinoma: dimethylarginine dimethylaminohydrolase 1.
Topics: Aged; Amidohydrolases; Arginine; Carcinoma, Hepatocellular; Cell Hypoxia; Female; Hep G2 Cells; Humans; Liver Neoplasms; Male; Neovascularization, Pathologic; Nitric Oxide; Nitric Oxide Synthase Type II; Vascular Endothelial Growth Factor A | 2017 |
Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction.
Topics: Amidohydrolases; Animals; Arginine; Atrial Natriuretic Factor; Disease Models, Animal; Fibrosis; Genetic Predisposition to Disease; Hypertrophy, Left Ventricular; Male; Mice, Knockout; Myocytes, Cardiac; Nitric Oxide; Phenotype; Signal Transduction; Tyrosine; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2017 |
Influence on serum asymmetric dimethylarginine (ADMA) concentrations of human paraoxonase 1 polymorphism (Q192R) and exposure to polycyclic aromatic hydrocarbons (PAHs) in Mexican women, a gene-environment interaction.
Topics: Adult; Alleles; Arginine; Aryldialkylphosphatase; Biomarkers; Cardiovascular Diseases; Creatinine; Environmental Exposure; Environmental Pollutants; Female; Gene Frequency; Gene-Environment Interaction; Genetic Predisposition to Disease; Genotype; Humans; Mexico; Polycyclic Aromatic Hydrocarbons; Polymorphism, Genetic; Pyrenes; Risk Factors | 2017 |
Resveratrol prevents the combined maternal plus postweaning high-fat-diets-induced hypertension in male offspring.
Topics: Animals; Arginine; Blood Pressure; Diet, High-Fat; Female; Hypertension; Male; Maternal Nutritional Physiological Phenomena; Oxidative Stress; Pregnancy; Rats, Sprague-Dawley; Renin-Angiotensin System; Resveratrol; Stilbenes; Weaning | 2017 |
Asymmetric dimethylarginine and symmetric dimethylarginine prospectively relates to carotid wall thickening in black men: the SABPA study.
Topics: Adult; Arginine; Black People; Cardiovascular Diseases; Carotid Intima-Media Thickness; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Regression Analysis; South America; White People | 2017 |
Effects of propolis, caffeic acid phenethyl ester, and pollen on renal injury in hypertensive rat: An experimental and theoretical approach.
Topics: Animals; Antioxidants; Arginine; Aryldialkylphosphatase; Binding Sites; Caffeic Acids; Glutathione Reductase; Half-Life; Hypertension; Kidney Diseases; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; NF-kappa B; Oxidative Stress; Phenylethyl Alcohol; Pollen; Propolis; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley | 2017 |
Systemic vascular resistance and endogenous inhibitors of nitric oxide synthesis in early- compared to late-onset preeclampsia: preliminary findings.
Topics: Adult; Arginine; Case-Control Studies; Female; Humans; Pre-Eclampsia; Pregnancy; Vascular Resistance; Young Adult | 2017 |
Asymmetric Dimethylarginine Predicts Long-Term Outcome in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.
Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Disease Progression; Female; Humans; Male; Middle Aged; Prognosis; Proportional Hazards Models; Pulmonary Disease, Chronic Obstructive; Risk Factors; Severity of Illness Index; Survival Rate; Switzerland; Time Factors | 2017 |
Asymmetric dimethylarginine downregulates sarco/endoplasmic reticulum calcium‑ATPase 3 and induces endoplasmic reticulum stress in human umbilical vein endothelial cells.
Topics: Apoptosis; Arginine; Calcium; Caspase 3; Cells, Cultured; Down-Regulation; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Endoribonucleases; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Human Umbilical Vein Endothelial Cells; Humans; Membrane Proteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Transcription Factor CHOP | 2017 |
Sub-therapeutic doses of fluvastatin and valsartan are more effective than therapeutic doses in providing beneficial cardiovascular pleiotropic effects in rats: A proof of concept study.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Arginine; Blood Pressure; Cholesterol; Coronary Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Indoles; Male; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Rats, Wistar; Receptor, Endothelin A; Time Factors; Valsartan; Vasodilation | 2017 |
Blood asymmetric dimethylarginine and nitrite/nitrate concentrations in short-stature children born small for gestational age with and without growth hormone therapy.
Topics: Arginine; Biomarkers; Body Height; Case-Control Studies; Child; Child, Preschool; Dwarfism; Female; Growth Hormone; Humans; Infant, Newborn; Infant, Small for Gestational Age; Longitudinal Studies; Male; Nitrates; Nitrites | 2018 |
Inverse relations of serum phosphatidylcholines and lysophosphatidylcholines with vascular damage and heart rate in patients with atherosclerosis.
Topics: Aged; Angiography, Digital Subtraction; Arginine; Biomarkers; Case-Control Studies; Coronary Artery Disease; Cross-Sectional Studies; Endothelium, Vascular; Heart Rate; Humans; Lysophosphatidylcholines; Male; Metabolomics; Middle Aged; Peripheral Arterial Disease; Phosphatidylcholines; Pulse Wave Analysis; Vascular Stiffness | 2018 |
Spontaneous variability of pre-dialysis concentrations of uremic toxins over time in stable hemodialysis patients.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Arginine; beta 2-Microglobulin; Creatinine; Female; Hemodialysis Solutions; Hippurates; Humans; Indican; Male; Middle Aged; Observer Variation; Phosphorus; Renal Dialysis; Renal Insufficiency, Chronic; Toxins, Biological; Urea; Uric Acid | 2017 |
Time-Dependent Production of Endothelium-Related Biomarkers is Affected Differently in Hemorrhagic and Septic Shocks.
Topics: Animals; Antioxidants; Arginine; Biomarkers; Blood Pressure; Disease Models, Animal; Endothelial Cells; Hydrogen Sulfide; Male; Nitric Oxide; Rats, Wistar; Resuscitation; Shock, Hemorrhagic; Shock, Septic; Time Factors | 2018 |
Association of serum asymmetric dimethylarginine, homocysteine, and l-arginine concentrations during early pregnancy with hypertensive disorders of pregnancy.
Topics: Adult; Area Under Curve; Arginine; Biomarkers; Body Mass Index; Case-Control Studies; Female; Gestational Age; Homocysteine; Humans; Logistic Models; Nitric Oxide; Overweight; Parity; Pre-Eclampsia; Pregnancy; Risk Factors | 2017 |
Diclofenac but not celecoxib improves endothelial function in rheumatoid arthritis: A study in adjuvant-induced arthritis.
Topics: Animals; Aorta, Thoracic; Arginase; Arginine; Arthritis, Experimental; Biological Factors; Blood Pressure; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Endothelium, Vascular; Freund's Adjuvant; In Vitro Techniques; Male; NADPH Oxidases; Nitric Oxide Synthase Type III; Phosphorylation; Rats, Inbred Lew; Vasodilation; Vasodilator Agents | 2017 |
Opposing effects of rheumatoid arthritis and low dose prednisolone on arginine metabolomics.
Topics: Administration, Oral; Aged; Arginine; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Chromatography, Liquid; Drug Administration Schedule; Endothelium, Vascular; Female; Glucocorticoids; Homoarginine; Humans; Male; Mass Spectrometry; Metabolomics; Middle Aged; Prednisolone; Time Factors; Treatment Outcome | 2017 |
Independent Association of Plasma Hydroxysphingomyelins With Physical Function in the Atherosclerosis Risk in Communities (ARIC) Study.
Topics: Aged; Arginine; Atherosclerosis; Cross-Sectional Studies; Female; Hand Strength; Humans; Linear Models; Male; Phosphatidylcholines; Physical Fitness; Risk Factors; Sphingomyelins; Walking Speed | 2018 |
Impaired Arginine Metabolism Coupled to a Defective Redox Conduit Contributes to Low Plasma Nitric Oxide in Polycystic Ovary Syndrome.
Topics: Amidohydrolases; Arginine; Argininosuccinate Lyase; Cationic Amino Acid Transporter 1; Female; Humans; Hydrogen Peroxide; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Oxidation-Reduction; Polycystic Ovary Syndrome; Protein-Arginine N-Methyltransferases; Repressor Proteins | 2017 |
Relationship between asymmetric dimethylarginine, nitrite and genetic polymorphisms: Impact on erectile dysfunction therapy.
Topics: Amidohydrolases; Arginine; Biomarkers; Erectile Dysfunction; Humans; Male; Nitrites; Phosphodiesterase 5 Inhibitors; Polymorphism, Genetic; Sildenafil Citrate | 2017 |
Elevated plasma asymmetric dimethylarginine levels in children with beta-thalassemia major may be an early marker for endothelial dysfunction.
Topics: Adolescent; Arginine; beta-Thalassemia; Biomarkers; C-Reactive Protein; Child; Child, Preschool; Endothelium; Female; Humans; Intercellular Adhesion Molecule-1; Male; P-Selectin; Serum Amyloid P-Component; Vascular Cell Adhesion Molecule-1 | 2018 |
ADMA reduction does not protect mice with streptozotocin-induced diabetes mellitus from development of diabetic nephropathy.
Topics: Albuminuria; Amidohydrolases; Animals; Arginine; Cell Proliferation; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Progression; Down-Regulation; Genetic Predisposition to Disease; Glomerular Mesangium; Glomerulonephritis; Hydrolysis; Kidney; Male; Mice, Inbred C57BL; Mice, Transgenic; Phenotype; Streptozocin | 2017 |
Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y⁺LAT2 Carrier-Mediated Loss.
Topics: Amidohydrolases; Amino Acid Transport System y+; Ammonia; Animals; Arginine; Astrocytes; Cell Line; Cells, Cultured; Fusion Regulatory Protein 1, Light Chains; Nitric Oxide; Protein-Arginine N-Methyltransferases; Rats; Rats, Wistar | 2017 |
Symmetric dimethylarginine (SDMA) outperforms asymmetric dimethylarginine (ADMA) and other methylarginines as predictor of renal and cardiovascular outcome in non-dialysis chronic kidney disease.
Topics: Aged; Arginine; Biomarkers; Cardiovascular Diseases; Chromatography, Liquid; Disease Progression; Female; Germany; Humans; Incidence; Male; Middle Aged; omega-N-Methylarginine; Prognosis; Renal Dialysis; Renal Insufficiency, Chronic; Risk Assessment; Risk Factors | 2018 |
Elevated Levels of ADMA Are Associated with Lower DDAH2 and Higher PRMT1 in LPS-Induced Endometritis Rats.
Topics: Amidohydrolases; Animals; Arginine; Dinoprost; Disease Models, Animal; Down-Regulation; Endometriosis; Female; Interleukin-6; Lipopolysaccharides; Peroxidase; Protein-Arginine N-Methyltransferases; Rats, Wistar; Reactive Oxygen Species; Tumor Necrosis Factor-alpha; Up-Regulation; Uterus | 2018 |
Erythropoietin reduces collagen deposition after myocardial infarction but does not improve cardiac function.
Topics: Animals; Apoptosis; Arginine; Collagen; Diastole; Erythropoietin; Glutathione; Heart; Hematocrit; Hemoglobins; Male; Myocardial Infarction; Myocardium; Oxidative Stress; Rats | 2018 |
Effects of betaine supplementation on nitric oxide metabolism, atherosclerotic parameters, and fatty liver in guinea pigs fed a high cholesterol plus methionine diet.
Topics: Animals; Arginine; Atherosclerosis; Betaine; Cholesterol; Cholesterol, Dietary; Diet, High-Fat; Dietary Supplements; Fatty Liver; Guinea Pigs; Hyperlipidemias; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methionine; Nitric Oxide; Tyrosine | 2018 |
New Oxidative Stress Markers Useful in the Diagnosis of Acute Appendicitis in Children: Thiol/Disulfide Homeostasis and the Asymmetric Dimethylarginine Level.
Topics: Adolescent; Antioxidants; Appendicitis; Arginine; Biomarkers; C-Reactive Protein; Case-Control Studies; Child; Disulfides; Female; Homeostasis; Humans; Male; Oxidative Stress; Sulfhydryl Compounds | 2020 |
Dimethylarginine dimethylaminohydrolase-1 (DDAH1) is frequently upregulated in prostate cancer, and its overexpression conveys tumor growth and angiogenesis by metabolizing asymmetric dimethylarginine (ADMA).
Topics: Amidohydrolases; Animals; Arginine; Cell Movement; Cell Proliferation; Fibroblast Growth Factor 2; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-8; Male; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasm Transplantation; Neovascularization, Pathologic; Nitric Oxide; Nitric Oxide Synthase Type II; PC-3 Cells; Platelet Endothelial Cell Adhesion Molecule-1; Prostatic Neoplasms; Signal Transduction; Up-Regulation; Vascular Endothelial Growth Factor A | 2018 |
Testosterone Deficiency Causes Endothelial Dysfunction via Elevation of Asymmetric Dimethylarginine and Oxidative Stress in Castrated Rats.
Topics: Animals; Arginine; Castration; Endothelium; Erectile Dysfunction; Humans; Male; Nitric Oxide; Oxidative Stress; Penile Erection; Penis; Rats; Rats, Wistar; Testosterone | 2017 |
Relation of Serum ADMA, Apelin-13 and LOX-1 Levels with Inflammatory and Echocardiographic Parameters in Hemodialysis Patients.
Topics: Arginine; Biomarkers; C-Reactive Protein; Echocardiography; Enzyme-Linked Immunosorbent Assay; Female; Humans; Inflammation; Intercellular Signaling Peptides and Proteins; Lymphocytes; Male; Middle Aged; Neutrophils; Renal Dialysis; Scavenger Receptors, Class E | 2018 |
The prognostic value of asymmetric dimethylarginine in patients with cardiac syndrome X.
Topics: Aged; Arginine; Endothelium, Vascular; Female; Humans; Male; Metabolic Syndrome; Middle Aged; Prognosis | 2017 |
Role of DDAH/ADMA pathway in TGF-β1-mediated activation of hepatic stellate cells.
Topics: Amidohydrolases; Animals; Arginine; Cell Proliferation; Collagen Type I; Hepatic Stellate Cells; Male; MAP Kinase Signaling System; Rats; Signal Transduction; Transforming Growth Factor beta1 | 2018 |
Distinct Roles of Endothelial Dysfunction and Inflammation in Intracranial Atherosclerotic Stroke.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Aged; Arginine; Biomarkers; Endothelium; Female; Humans; Inflammation; Intracranial Arteriosclerosis; Male; Middle Aged; Stroke | 2017 |
Protein arginine methyltransferase expression and activity during myogenesis.
Topics: Animals; Arginine; Cell Differentiation; Gene Expression Regulation, Developmental; Histones; Mice; Muscle Cells; Muscle Development; Muscle Fibers, Skeletal; Muscle, Skeletal; Protein-Arginine N-Methyltransferases | 2018 |
Inverse correlation between maternal plasma asymmetric dimethylarginine (ADMA) and birthweight percentile in women with impaired placental perfusion: circulating ADMA as an NO-independent indicator of fetal growth restriction?
Topics: Adult; Arginine; Biomarkers; Birth Weight; Female; Fetal Growth Retardation; Fetus; Gestational Age; Humans; Infant, Newborn; Male; Nitrates; Nitric Oxide; Nitrites; Placenta; Pre-Eclampsia; Pregnancy; Pregnancy Outcome | 2018 |
Amniotic Fluid Arginine from Gestational Weeks 13 to 15 Is a Predictor of Birth Weight, Length, and Head Circumference.
Topics: Adult; Amniotic Fluid; Arginine; Birth Weight; Dietary Supplements; Female; Fetal Growth Retardation; Humans; Infant; Male; Middle Aged; Nitric Oxide; Pregnancy; Pregnancy Trimesters; Young Adult | 2017 |
Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function.
Topics: Animals; Arginine; Disease Models, Animal; Glutathione Peroxidase; Heart Diseases; Mice; Mice, Knockout; Platelet Aggregation; Reactive Oxygen Species; Renal Insufficiency, Chronic; Thrombosis; Ventricular Dysfunction, Left | 2018 |
Anti-Atherogenic Activity of Polyphenol-Rich Extract from Bee Pollen.
Topics: Angiotensin II; Animals; Arginine; Atherosclerosis; Bees; Cholesterol; Coronary Artery Disease; Diet, High-Fat; Dose-Response Relationship, Drug; Female; Hypercholesterolemia; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Peptidyl-Dipeptidase A; Pollen; Polyphenols | 2017 |
Serum Concentrations of New Predictive Cardiovascular Disease Biomarkers in Mexican Women Exposed to Lead.
Topics: Adiponectin; Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Cardiovascular Diseases; Chemokines; Cross-Sectional Studies; Environmental Exposure; Fatty Acid-Binding Proteins; Female; Humans; Intercellular Signaling Peptides and Proteins; Lead; Male; Mexico; Middle Aged | 2018 |
Global arginine bioavailability ratio is decreased in patients with major depressive disorder.
Topics: Adult; Aged; Arginine; Biological Availability; Citrulline; Depressive Disorder, Major; Female; Humans; Male; Middle Aged; Nitric Oxide; Ornithine; Oxidative Stress; Surveys and Questionnaires; Young Adult | 2018 |
The farnesoid X receptor agonist obeticholic acid upregulates biliary excretion of asymmetric dimethylarginine via MATE-1 during hepatic ischemia/reperfusion injury.
Topics: Animals; Antiporters; Arginine; Biliary Tract; Blotting, Western; Carrier Proteins; Chenodeoxycholic Acid; Liver Diseases; Male; Nitric Oxide Synthase; Organic Cation Transport Proteins; Protein-Arginine N-Methyltransferases; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Reperfusion Injury; RNA, Messenger; Up-Regulation | 2018 |
Asymmetric dimethylarginine (ADMA) is identified as a potential biomarker of insulin resistance in skeletal muscle.
Topics: Adolescent; Adult; Animals; Arginine; Biomarkers; Cohort Studies; Humans; Insulin Resistance; Mice; Mice, Inbred C57BL; Middle Aged; Muscle, Skeletal; Signal Transduction | 2018 |
Relation of asymmetrical dimethylarginine levels with renal outcomes in hypertensive patients with and without type 2 diabetes mellitus.
Topics: Aged; Albuminuria; Arginine; Biomarkers; Case-Control Studies; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Male; Middle Aged; Renal Insufficiency, Chronic | 2018 |
Asymmetric dimethylarginine levels are associated with augmentation index across naïve untreated patients with different hypertension phenotypes.
Topics: Adult; Arginine; Arterial Pressure; Biomarkers; Case-Control Studies; Essential Hypertension; Female; Humans; Hypertension; Male; Masked Hypertension; Middle Aged; Pulse Wave Analysis; Risk Factors; Vascular Stiffness; White Coat Hypertension | 2018 |
Increased Endothelial Dysfunction and Insulin Resistance in Patients with Klinefelter Syndrome.
Topics: Arginine; Biomarkers; Blood Glucose; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Cholesterol, HDL; Endothelium, Vascular; Humans; Inflammation; Inflammation Mediators; Insulin; Insulin Resistance; Klinefelter Syndrome; Male; Multivariate Analysis; Prevalence; Risk Factors; Testosterone; Turkey; Young Adult | 2018 |
Kidney Mass Reduction Leads to l-Arginine Metabolism-Dependent Blood Pressure Increase in Mice.
Topics: Animals; Arginase; Arginine; Blood Pressure; Citrulline; Female; Kidney; Male; Mice, Inbred C57BL; Mice, Knockout; Nephrectomy; Nitric Oxide; Organ Size | 2018 |
Serum Methylarginines and Hearing Loss in a Population-based Cohort of Older Adults.
Topics: Aged; Arginine; Biomarkers; Cohort Studies; Cross-Sectional Studies; Female; Hearing Loss; Humans; Male; Middle Aged | 2018 |
Homoarginine and inhibition of human arginase activity: kinetic characterization and biological relevance.
Topics: Aged; Aged, 80 and over; Agmatine; Arginase; Arginine; Cell Line; Chromatography, Liquid; Enzyme Activation; Female; Homoarginine; Humans; Kinetics; Male; Proline; Protein Isoforms; Tandem Mass Spectrometry | 2018 |
Asymmetric dimethylarginine levels and diabetes duration: Relationship with measures of subclinical atherosclerosis and cardiac function in children and adolescents with Type 1 diabetes.
Topics: Adolescent; Adult; Arginine; Atherosclerosis; Carotid Intima-Media Thickness; Child; Diabetes Mellitus, Type 1; Echocardiography; Echocardiography, Doppler; Female; Humans; Male; Myocardium; Ventricular Function, Left; Young Adult | 2018 |
Malaria in pregnancy alters l-arginine bioavailability and placental vascular development.
Topics: Animals; Arginine; Female; Humans; Malaria; Mice; Nitric Oxide; Placenta; Pregnancy; Pregnancy Outcome; Prospective Studies | 2018 |
Estimation of asymmetric dimethylarginine (ADMA), placental growth factor (PLGF) and pentraxin 3 (PTX 3) in women with preeclampsia.
Topics: Adult; Arginine; Biomarkers; C-Reactive Protein; Case-Control Studies; Disease Progression; Female; Humans; India; Placenta Growth Factor; Pre-Eclampsia; Predictive Value of Tests; Pregnancy; Prospective Studies; ROC Curve; Serum Amyloid P-Component; Young Adult | 2018 |
Serum concentrations of asymmetric and symmetric dimethylarginine are associated with mortality in acute heart failure patients.
Topics: Acute Disease; Aged; Aged, 80 and over; Arginine; Biomarkers; Cohort Studies; Female; Heart Failure; Humans; Male; Mortality; Stroke Volume | 2018 |
Asymmetric and Symmetric Dimethylarginines are Markers of Delayed Cerebral Ischemia and Neurological Outcome in Patients with Subarachnoid Hemorrhage.
Topics: Adult; Aged; Arginine; Biomarkers; Brain Ischemia; Cerebral Angiography; Female; Humans; Incidence; Male; Middle Aged; Outcome Assessment, Health Care; Subarachnoid Hemorrhage | 2018 |
Endothelium, asymmetric dimethylarginine, and atherosclerosis in chronic kidney disease.
Topics: Arginine; Atherosclerosis; Endothelium; Humans; Radial Artery; Renal Insufficiency, Chronic | 2018 |
Asymmetric dimethylarginine as a useful risk marker of radial artery calcification in patients with advanced kidney disease.
Topics: Aged; Arginine; Biomarkers; Calcinosis; Female; Humans; Male; Middle Aged; Radial Artery; Renal Insufficiency, Chronic | 2018 |
Association of endothelial dysfunction with cardiovascular risk factors and new-onset diabetes mellitus in patients with hypertension.
Topics: Aged; Arginine; Brazil; C-Reactive Protein; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus, Type 2; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Hypertension; Male; Metabolic Syndrome; Middle Aged; Nitric Oxide Synthase; Predictive Value of Tests; Prospective Studies; Risk Factors; Triglycerides | 2018 |
Alterations in plasma L-arginine and methylarginines in heart failure and after heart transplantation.
Topics: Arginine; Biomarkers; Citrulline; Endothelium, Vascular; Female; Heart Failure; Heart Transplantation; Hemodynamics; Humans; Male; Middle Aged; Nitric Oxide; Ornithine; Prospective Studies; Time Factors; Treatment Outcome | 2018 |
Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction.
Topics: Arginine; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Endothelium; Feces; Female; Gastrointestinal Microbiome; HIV Infections; Humans; Inflammation; Kynurenine; Male; Metabolism; Middle Aged; Neopterin; Risk Factors; RNA, Ribosomal, 16S; Tryptophan | 2018 |
Oxysterols Increase Inflammation, Lipid Marker Levels and Reflect Accelerated Endothelial Dysfunction in Experimental Animals.
Topics: Animals; Arginine; Aryldialkylphosphatase; C-Reactive Protein; Cholesterol; Dyslipidemias; Homocysteine; Hypercholesterolemia; Inflammation; Interleukin-6; Lipids; Male; Oxysterols; Rabbits; Tumor Necrosis Factor-alpha | 2018 |
Asymmetric dimethylarginine contributes to retinal neovascularization of diabetic retinopathy through EphrinB2 pathway.
Topics: Amidohydrolases; Animals; Arginine; Cell Hypoxia; Cell Line; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelial Cells; Ephrin-B2; Human Umbilical Vein Endothelial Cells; Humans; Macaca mulatta; Male; Protein-Arginine N-Methyltransferases; Rats, Sprague-Dawley; Retinal Neovascularization; Retinal Vessels; RNA Interference; Signal Transduction | 2018 |
Asymmetric and symmetric dimethylarginines and mortality in patients with hematological malignancies-A prospective study.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers, Tumor; Case-Control Studies; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; Middle Aged; Prognosis; Prospective Studies; Survival Rate; Young Adult | 2018 |
Dimethylarginine dimethylaminohydrolase (DDAH) overexpression enhances wound repair in airway epithelial cells exposed to agricultural organic dust.
Topics: Amidohydrolases; Animal Husbandry; Animals; Arginine; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dust; Epithelial Cells; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Protein Kinase C; Trachea; Wound Healing | 2018 |
Asymmetrical Dimethylarginine Levels in Hepatitis B Virus-Positive Patients.
Topics: Adult; Alanine Transaminase; alpha-Fetoproteins; Arginine; Aspartate Aminotransferases; Carrier State; Case-Control Studies; DNA, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged | 2018 |
Correlation of Salusin Beta with hs-CRP and ADMA in Hypertensive Children and Adolescents.
Topics: Adolescent; Arginine; C-Reactive Protein; Child; Cohort Studies; Female; Humans; Hypertension; Intercellular Signaling Peptides and Proteins; Male; Prospective Studies | 2018 |
Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis.
Topics: Aged; Arginase; Arginine; Arthritis, Rheumatoid; Biomarkers; Cardiovascular Diseases; Comorbidity; Female; Humans; Hyperlipidemias; Hypertension; Male; Middle Aged; Prevalence; Risk Factors; United States | 2018 |
Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Blood Pressure; Blood Urea Nitrogen; Cardiovascular Diseases; Celecoxib; Creatinine; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Kidney; Metabolome; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteoarthritis; Placebo Effect | 2018 |
Role of plasma asymmetric dimethyl-L-arginine levels in detection of pulmonary hypertension in children with CHD.
Topics: Arginine; Biomarkers; Child, Preschool; Echocardiography; Female; Follow-Up Studies; Heart Defects, Congenital; Humans; Hypertension, Pulmonary; Infant; Infant, Newborn; Male; Nitric Oxide Synthase; Predictive Value of Tests; Prospective Studies; Pulmonary Wedge Pressure | 2018 |
Evaluation of serum Asymmetric Dimethyl Arginine concentrations in coronary artery disease patients without traditional cardiovascular risk factors.
Topics: Arginine; Biomarkers; Case-Control Studies; Coronary Artery Disease; Coronary Stenosis; Female; Humans; Male; Middle Aged | 2018 |
Gender differences in the relationships between chronic kidney disease, asymmetric dimethylarginine, and sleep quality: The HEIJO-KYO cohort.
Topics: Aged; Arginine; Cohort Studies; Female; Humans; Male; Multivariate Analysis; Quality of Life; Renal Insufficiency, Chronic; Sex Characteristics; Sex Factors; Sleep Hygiene; Surveys and Questionnaires | 2018 |
Proton pump inhibitors and Raynaud's phenomenon: is there a link?
Topics: Adverse Drug Reaction Reporting Systems; Amidohydrolases; Arginine; Gastroesophageal Reflux; Histamine H2 Antagonists; Humans; Pharmacovigilance; Proton Pump Inhibitors; Raynaud Disease | 2018 |
FGF23 impairs peripheral microvascular function in renal failure.
Topics: Animals; Arginine; Cells, Cultured; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Endothelial Cells; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Gracilis Muscle; Humans; Kidney; Male; Mice, Inbred C57BL; Microcirculation; Microvessels; Renal Insufficiency, Chronic; Signal Transduction; Vascular Resistance; Vasodilation; Vasodilator Agents | 2018 |
SZSJ protects against insomnia by a decrease in ADMA level and an improvement in DDAH production in sleep-deprived rats.
Topics: Amidohydrolases; Animals; Arginine; Hypnotics and Sedatives; Male; Protective Agents; Rats; Rats, Sprague-Dawley; Sleep Deprivation; Sleep Initiation and Maintenance Disorders; Ziziphus | 2018 |
Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons.
Topics: Aging; Amino Acid Sequence; Animals; Arginine; Cell Line; Cyclic AMP Response Element-Binding Protein; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; Isometric Contraction; Male; Mice; Mice, Knockout; Mice, Transgenic; Motor Neurons; Muscle Cells; Neuromuscular Junction; Protein-Arginine N-Methyltransferases; Recombinant Fusion Proteins; Reflex, Abnormal; RNA Interference; RNA, Small Interfering; Rotarod Performance Test; Spinal Cord | 2018 |
Nephroprotective effects of nebivolol in 2K1C rats through regulation of the kidney ROS-ADMA-NO pathway.
Topics: Amidohydrolases; Angiotensin II; Animals; Arginine; Atenolol; Blood Pressure; Hypertension, Renovascular; Kidney; Kidney Function Tests; Male; NADPH Oxidases; Nebivolol; Nitric Oxide; Nitric Oxide Synthase; Protective Agents; Protein-Arginine N-Methyltransferases; Rats; Reactive Oxygen Species; Signal Transduction | 2018 |
Plasma Homoarginine Concentrations According to Use of Hormonal Contraception.
Topics: Adolescent; Adult; Arginine; Chromatography, Liquid; Contraception; Contraceptives, Oral, Hormonal; Estrogens; Female; Homoarginine; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Progestins; Tandem Mass Spectrometry; Young Adult | 2018 |
ADMA, homocysteine and redox status improvement affected by 7-nitroindazole in spontaneously hypertensive rats.
Topics: Animals; Aorta; Arginine; Biomarkers; Disease Models, Animal; Enzyme Inhibitors; Heart Ventricles; Homocysteine; Hypertension; Indazoles; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidation-Reduction; Rats, Inbred SHR | 2018 |
Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial.
Topics: Aged; Aged, 80 and over; Arginine; Case-Control Studies; Citrulline; Cohort Studies; Diabetes Mellitus, Type 2; Diet, Fat-Restricted; Diet, Mediterranean; Female; Humans; Incidence; Insulin Resistance; Male; Middle Aged; omega-N-Methylarginine; Ornithine; Risk Factors | 2019 |
Cerebrovascular reactivity and cerebral perfusion of rats with acute liver failure: role of L-glutamine and asymmetric dimethylarginine in L-arginine-induced response.
Topics: Animals; Arginine; Brain; Cerebrovascular Circulation; Extracellular Space; Glutamine; Liver Failure, Acute; Magnetic Resonance Imaging; Male; Middle Cerebral Artery; Muscle, Smooth, Vascular; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Thioacetamide | 2018 |
Serum asymmetric dimethylarginine and nitric oxide levels in Turkish patients with acute ischemic stroke.
Topics: Aged; Aged, 80 and over; Arginine; Brain Ischemia; Female; Humans; Male; Middle Aged; Nitric Oxide; Stroke | 2019 |
Plethysmographic and biochemical markers in the diagnosis of endothelial dysfunction in pediatric acute lymphoblastic leukemia survivors - new applications.
Topics: Adolescent; Arginine; Biomarkers; C-Reactive Protein; Child; E-Selectin; Endothelium, Vascular; Female; Humans; Male; Plethysmography; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Risk Factors; Vascular Diseases | 2018 |
Urinary sodium-to-potassium ratio and serum asymmetric dimethylarginine levels in patients with type 2 diabetes.
Topics: Adult; Aged, 80 and over; Arginine; Blood Pressure; Carotid Intima-Media Thickness; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Obesity; Potassium; Sodium | 2018 |
Usefulness of Asymmetric Dimethylarginine to Predict Outcomes After Heart Transplantation.
Topics: Adult; Allografts; Arginine; Biomarkers; California; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Heart Transplantation; Humans; Incidence; Male; Middle Aged; Nitric Oxide Synthase; Postoperative Period; Primary Graft Dysfunction; Prognosis; Retrospective Studies; Risk Assessment; Risk Factors; Survival Rate; Time Factors | 2018 |
Development of a novel UHPLC-MS/MS-based platform to quantify amines, amino acids and methylarginines for applications in human disease phenotyping.
Topics: Aged; Amines; Amino Acids; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Female; Humans; Male; Prognosis; Systemic Inflammatory Response Syndrome; Tandem Mass Spectrometry | 2018 |
Homoarginine/ADMA ratio and homoarginine/SDMA ratio as independent predictors of cardiovascular mortality and cardiovascular events in lower extremity arterial disease.
Topics: Aged; Arginine; Biomarkers; Cardiovascular Diseases; Cardiovascular System; Female; Homoarginine; Humans; Incidence; Lower Extremity; Male; Middle Aged; Prospective Studies; Risk Factors; Vascular Diseases | 2018 |
Association of Uremic Toxins and Inflammatory Markers with Physical Performance in Dialysis Patients.
Topics: Adult; Aged; Arginine; beta 2-Microglobulin; Biomarkers; C-Reactive Protein; Female; Hand Strength; Humans; Indican; Inflammation; Insulin-Like Growth Factor I; Interleukin-6; Male; Middle Aged; Myostatin; Physical Functional Performance; Renal Dialysis; Toxins, Biological; Urea; Uremia; Walking | 2018 |
AGXT2 and DDAH-1 genetic variants are highly correlated with serum ADMA and SDMA levels and with incidence of coronary artery disease in Egyptians.
Topics: Adult; Amidohydrolases; Arginine; Case-Control Studies; Coronary Artery Disease; Egypt; Female; Genetic Variation; Genotype; Humans; Incidence; Male; Middle Aged; Nitric Oxide; Polymorphism, Single Nucleotide; Transaminases | 2018 |
Role of microcirculatory function and plasma biomarkers in determining the development of cardiovascular adverse events in patients with peripheral arterial disease: A 5-year follow-up.
Topics: Arginine; Biomarkers; Blood Flow Velocity; C-Reactive Protein; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Male; Microcirculation; Middle Aged; Peripheral Arterial Disease; Predictive Value of Tests; Prospective Studies; Risk Factors; Turkey | 2018 |
Utility of homoarginine in the GC-MS quantification of asymmetric dimethylarginine (ADMA) in human serum proteins.
Topics: Aged; Amino Acids; Arginine; Blood Proteins; Female; Gas Chromatography-Mass Spectrometry; Homoarginine; Humans; Male | 2018 |
Hemodynamic, Autonomic, and Vascular Function Changes after Sleep Deprivation for 24, 28, and 32 Hours in Healthy Men.
Topics: Adult; Arginine; Autonomic Nervous System; Baroreflex; Blood Pressure; Female; Healthy Volunteers; Heart; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Nitric Oxide Synthase Type III; Sleep Deprivation; Young Adult | 2018 |
ADMA and NT pro-BNP are associated with overall mortality in elderly.
Topics: Age Distribution; Aged; Aged, 80 and over; Arginine; Austria; Biomarkers; Body Mass Index; Cardiovascular Diseases; Female; Health Services for the Aged; Hospitalization; Humans; Male; Natriuretic Peptide, Brain; Peptide Fragments; Prospective Studies; Risk Factors; Sex Distribution; Survival Analysis | 2019 |
Serum ADMA, endothelial dysfunction, and atherosclerosis in hypervolemic \
hemodialysis patients
Topics: Arginine; Atherosclerosis; C-Reactive Protein; Carotid Intima-Media Thickness; Cohort Studies; Echocardiography; Female; Humans; Male; Middle Aged; Renal Dialysis | 2018 |
Arginine bioavailability and endothelin-1 system in the regulation of vascular function of umbilical vein endothelial cells from intrauterine growth restricted newborns.
Topics: Adult; Amidohydrolases; Arginase; Arginine; Case-Control Studies; Cell Proliferation; Cells, Cultured; Endothelin-1; Female; Fetal Growth Retardation; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Infant, Newborn; Male; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Pregnancy; Protein-Arginine N-Methyltransferases; Receptor, Endothelin B; Repressor Proteins; Signal Transduction; Umbilical Veins | 2018 |
Probucol improves erectile function via Activation of Nrf2 and coordinates the HO-1 / DDAH / PPAR-γ/ eNOS pathways in streptozotocin-induced diabetic rats.
Topics: Amidohydrolases; Animals; Arginine; Blood Glucose; Body Weight; Cyclic GMP; Diabetes Mellitus, Experimental; Erectile Dysfunction; Heme Oxygenase-1; Male; Malondialdehyde; NF-E2-Related Factor 2; Nitric Oxide Synthase Type III; PPAR gamma; Probucol; Rats, Sprague-Dawley; Signal Transduction; Streptozocin; Superoxide Dismutase | 2018 |
Impact of arsenic exposure on clinical biomarkers indicative of cardiovascular disease risk in Mexican women.
Topics: Adult; Aged; Arginine; Arsenic; Biomarkers; Cardiovascular Diseases; Cross-Sectional Studies; Drinking Water; Environmental Exposure; Fatty Acid-Binding Proteins; Female; Humans; Male; Mexico; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Risk Factors; Surveys and Questionnaires; Water Pollutants, Chemical | 2019 |
Protein-energy wasting and asymmetric dimethylarginine in peritoneal dialysis patients.
Topics: Adiponectin; Adult; Aged; Arginine; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Energy Metabolism; Humans; Interleukin-6; Kidney Failure, Chronic; Leptin; Lipoproteins, LDL; Middle Aged; Peritoneal Dialysis; Risk Factors; Tumor Necrosis Factor-alpha | 2018 |
Alterations in arginine and energy metabolism, structural and signalling lipids in metastatic breast cancer in mice detected in plasma by targeted metabolomics and lipidomics.
Topics: Animals; Arginase; Arginine; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Chromatography, High Pressure Liquid; Disease Models, Animal; Energy Metabolism; Female; Humans; Lipid Metabolism; Lipids; Metabolomics; Mice; Mice, Inbred BALB C; Neoplasm Staging; Polyamines; Tandem Mass Spectrometry | 2018 |
Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity.
Topics: Amidohydrolases; Arginine; Biomarkers; Humans; Organ Dysfunction Scores; Polymorphism, Single Nucleotide; Protective Agents; Shock, Septic; Statistics, Nonparametric; Time Factors | 2018 |
Chronic intermittent hypoxia-mediated renal sympathetic nerve activation in hypertension and cardiovascular disease.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Angiotensins; Animals; Arginine; Cardiovascular Diseases; Deoxyguanosine; Disease Models, Animal; Humans; Hypertension; Hypoxia; Kidney; Male; Mice; Mice, Inbred C57BL; Norepinephrine; Oxidative Stress; Sympathectomy; Sympathetic Nervous System | 2018 |
Plasma asymmetric dimethylarginine concentrations are not related to differences in maximal oxygen uptake in endurance trained and untrained men.
Topics: Adult; Arginine; Endurance Training; Exercise; Exercise Test; Humans; Male; Muscles; Nitric Oxide; Oxygen; Physical Endurance | 2019 |
DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats.
Topics: Amidohydrolases; Animals; Arginine; Cell Line; Diabetic Cardiomyopathies; Fibrosis; Male; Matrix Metalloproteinase 2; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Rats; Signal Transduction; Tissue Inhibitor of Metalloproteinase-2 | 2019 |
The iridoid loganic acid and anthocyanins from the cornelian cherry (Cornus mas L.) fruit increase the plasma l-arginine/ADMA ratio and decrease levels of ADMA in rabbits fed a high-cholesterol diet.
Topics: Amidohydrolases; Animals; Anthocyanins; Arginine; Atherosclerosis; Cholesterol, Dietary; Citrulline; Cornus; Dimethylamines; Fruit; Iridoids; Liver; Male; Nitric Oxide Synthase Type III; Rabbits | 2019 |
Association of serum asymmetric dimethyl-arginine and troponin I levels as a risk of myocardial infarction in thalassemia.
Topics: Arginine; Biomarkers; Case-Control Studies; Creatine Kinase, MB Form; Humans; L-Lactate Dehydrogenase; Myocardial Infarction; Risk Factors; Thalassemia; Troponin I | 2018 |
Guanidino compound ratios are associated with stroke etiology, internal carotid artery stenosis and CHA
Topics: Aged; Arginine; Biomarkers; Brain Ischemia; Carotid Arteries; Carotid Stenosis; Cross-Sectional Studies; Female; Homoarginine; Humans; Intracranial Hemorrhages; Male; Middle Aged; Recurrence; Stroke | 2019 |
Novel Cellularly Active Inhibitor Regresses DDAH1 Induced Prostate Tumor Growth by Restraining Tumor Angiogenesis through Targeting DDAH1/ADMA/NOS Pathway.
Topics: Amidohydrolases; Animals; Antineoplastic Agents; Arginine; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemokines; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice, Nude; Molecular Docking Simulation; Neovascularization, Pathologic; Nitric Oxide; Nitric Oxide Synthase Type II; Prostatic Neoplasms; Pyridines; Signal Transduction; Transcription Factors; Vascular Endothelial Growth Factor A | 2019 |
Is Asymmetric Dimethylarginine a Useful Biomarker in Children With Carbon Monoxide Poisoning?
Topics: Adolescent; Arginine; Biomarkers; Blood Gas Analysis; Carbon Monoxide Poisoning; Carboxyhemoglobin; Case-Control Studies; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lactic Acid; Male; Methemoglobin | 2019 |
Increased asymmetric dimethylarginine in vitamin B12 deficient adolescents.
Topics: Adolescent; Arginine; Atherosclerosis; Biomarkers; Carotid Arteries; Carotid Intima-Media Thickness; Case-Control Studies; Child; Chromatography, High Pressure Liquid; Echocardiography; Female; Humans; Hyperhomocysteinemia; Male; Vascular Stiffness; Vitamin B 12 Deficiency | 2019 |
Total methylated arginine load as a risk parameter in subjects with masked hypertension.
Topics: Arginine; Biomarkers; Blood Pressure Determination; Female; Humans; Hypertension; Male; Masked Hypertension; Middle Aged; Nitric Oxide; omega-N-Methylarginine; Risk Factors | 2020 |
Reduced asymmetric dimethylarginine accumulation through inhibition of the type I protein arginine methyltransferases promotes renal fibrosis in obstructed kidneys.
Topics: Animals; Arginine; Cell Line; Gene Expression Regulation, Enzymologic; Humans; Kidney Diseases; Male; Mice; Nitric Oxide; Protein-Arginine N-Methyltransferases; Specific Pathogen-Free Organisms; Ureteral Obstruction | 2019 |
LC-QQQ-MS routine analysis method for new biomarker quantification in plasma aimed at early chronic kidney disease diagnosis.
Topics: Arginine; Biomarkers; Child; Child, Preschool; Chromatography, Liquid; Citrulline; Creatinine; Early Diagnosis; Female; Glomerular Filtration Rate; Humans; Male; Metabolomics; Plasma; Renal Insufficiency, Chronic; S-Adenosylmethionine; Tandem Mass Spectrometry | 2019 |
Procyanidin B2 from lotus seedpod regulate NO/ADMA/DDAH pathway to treat insomnia in rats.
Topics: Amidohydrolases; Animals; Arginine; Biflavonoids; Brain; Catechin; Lotus; Neurons; Nitric Oxide; Proanthocyanidins; Rats; Rats, Sprague-Dawley; Seeds; Signal Transduction; Sleep; Sleep Initiation and Maintenance Disorders | 2019 |
The renal transport protein OATP4C1 mediates uptake of the uremic toxin asymmetric dimethylarginine (ADMA) and efflux of cardioprotective L-homoarginine.
Topics: Arginine; Cardiovascular Diseases; HEK293 Cells; Homoarginine; Humans; Inhibitory Concentration 50; Kidney; Kinetics; Organic Anion Transporters; Toxins, Biological | 2019 |
Plasma ADMA, urinary ADMA excretion, and late mortality in renal transplant recipients.
Topics: Adult; Arginine; Biomarkers; Cardiovascular Diseases; Creatinine; Female; Gas Chromatography-Mass Spectrometry; Humans; Kidney Transplantation; Male; Middle Aged; Netherlands; Tandem Mass Spectrometry; Transplant Recipients | 2019 |
Negative Ion Mode Collision-Induced Dissociation for Analysis of Protein Arginine Methylation.
Topics: Amino Acid Sequence; Arginine; omega-N-Methylarginine; Peptides; Protein Processing, Post-Translational; Proteins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2019 |
Asymmetric dimethylarginine - a prognostic marker for transplant outcome?
Topics: Arginine; Hematopoietic Stem Cell Transplantation; Prognosis; Stem Cell Transplantation | 2019 |
Asymmetric dimethylarginine as a potential biomarker for management and follow-up of phenylketonuria.
Topics: Arginine; Biomarkers; Case-Control Studies; Child; Creatinine; Cross-Sectional Studies; Diet, Protein-Restricted; Female; Humans; Male; Phenylketonurias; Spain | 2019 |
Increased plasma concentration of 4-pyridone-3-carboxamide-1-ß-D-ribonucleoside (4PYR) in lung cancer. Preliminary studies.
Topics: Aged; Arginine; Biomarkers, Tumor; Carcinoma, Squamous Cell; Endothelial Cells; Female; Humans; Lung Neoplasms; Male; Middle Aged; Niacinamide; Nucleosides; Pyridones; Tandem Mass Spectrometry | 2019 |
Dronedarone induces regression of coronary artery remodeling related to better global antioxidant status.
Topics: Animals; Antioxidants; Arginine; Coronary Vessels; Dronedarone; Male; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Remodeling; Vasoconstriction | 2019 |
Decline of popliteal artery flow-mediated dilation with aging and possible involvement of asymmetric dimethylarginine in healthy men.
Topics: Adult; Age Factors; Aging; Arginine; Brachial Artery; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Popliteal Artery; Reference Values; Sex Factors; Vasodilation | 2019 |
Synthesis of docosahexaenoic acid-loaded silver nanoparticles for improving endothelial dysfunctions in experimental diabetes.
Topics: Animals; Arginine; Aryldialkylphosphatase; Blood Glucose; Diabetes Mellitus, Experimental; DNA Damage; Docosahexaenoic Acids; Insulin; Male; Membrane Lipids; Metal Nanoparticles; Nitric Oxide; Rats, Wistar; Silver | 2019 |
Asymmetric dimethylation and citrullination of proteinic arginine and homoarginine synthesis in human Helicobacter pylori infection.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Citrullination; Citrulline; Female; Gas Chromatography-Mass Spectrometry; Helicobacter Infections; Helicobacter pylori; Homoarginine; Humans; Lysine; Male; Methylation; Middle Aged; Nitric Oxide; Ornithine | 2019 |
Distinct associations between plasma osteoprotegerin, homoarginine and asymmetric dimethylarginine in chronic kidney disease male patients with coronary artery disease.
Topics: Aged; Arginine; Biomarkers; Coronary Artery Disease; Homoarginine; Humans; Male; Middle Aged; Osteoprotegerin; Renal Insufficiency, Chronic | 2019 |
Asymmetric Dimethylarginine Predicts One-year Recurrent Cardiovascular Events: Potential Biomarker of "Toxin Syndrome" in Coronary Heart Disease.
Topics: Arginine; Biomarkers; Coronary Disease; Humans; Odds Ratio; Recurrence; Risk Factors; ROC Curve; Syndrome | 2019 |
Association between asymmetric dimethylarginine and in-stent restenosis tissue characteristics assessed by optical coherence tomography.
Topics: Aged; Arginine; Biomarkers; Coronary Angiography; Coronary Restenosis; Coronary Vessels; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Plaque, Atherosclerotic; Prospective Studies; Prosthesis Failure; Risk Factors; Time Factors; Tomography, Optical Coherence | 2019 |
The protective effects of polysaccharide extract from Xin-Ji-Er-Kang formula on Ang II-induced HUVECs injury, L-NAME-induced hypertension and cardiovascular remodeling in mice.
Topics: Angiotensin II; Animals; Aorta; Arginine; Blood Pressure; Cytokines; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Endothelial Cells; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Hypertension; Inflammation; Male; Malondialdehyde; Mice; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phytotherapy; Superoxide Dismutase; Vascular Remodeling | 2019 |
Asymmetric and Symmetric Protein Arginine Dimethylation: Concept and Postprandial Effects of High-Fat Protein Meals in Healthy Overweight Men.
Topics: Adult; Arginine; Biomarkers; Diet, High-Fat; Diet, High-Protein; Gas Chromatography-Mass Spectrometry; Humans; Interleukin-6; Male; Middle Aged; Overweight; Postprandial Period; Time Factors; Tumor Necrosis Factor-alpha; Urinalysis; Young Adult | 2019 |
The ameliorative effect of angiotensin 1-7 on experimentally induced-preeclampsia in rats: Targeting the role of peroxisome proliferator-activated receptors gamma expression & asymmetric dimethylarginine.
Topics: Angiotensin I; Animals; Arginine; Blood Pressure; Female; Oxidative Stress; Peptide Fragments; Placenta; PPAR gamma; Pre-Eclampsia; Pregnancy; Proteinuria; Rats, Wistar; Sodium | 2019 |
Establishment of reference values for the lysine acetylation marker N
Topics: Adolescent; Adult; Arginine; Biomarkers; Cardiovascular Diseases; Carnitine; Chromatography, Liquid; Citrulline; Creatinine; Female; Homoarginine; Humans; Lysine; Male; Middle Aged; Ornithine; Reference Values; Renal Insufficiency, Chronic; Tandem Mass Spectrometry; Young Adult | 2019 |
Metabolites of the Nitric Oxide (NO) Pathway Are Altered and Indicative of Reduced NO and Arginine Bioavailability in Patients with Cardiometabolic Diseases Complicated with Chronic Wounds of Lower Extremities: Targeted Metabolomics Approach (LC-MS/MS).
Topics: Aged; Arginine; Cardiovascular Diseases; Case-Control Studies; Chemokines; Citrulline; Cytokines; Female; Growth Hormone; Humans; Lower Extremity; Male; Metabolomics; Middle Aged; Nitric Oxide; Wounds and Injuries | 2019 |
Asymmetric dimethylarginine predicts impaired epicardial coronary vasomotion in patients with angina in the absence of obstructive coronary artery disease.
Topics: Angina Pectoris; Arginine; Biomarkers; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Female; Humans; Male; Middle Aged; Retrospective Studies; Risk Factors; Vasomotor System | 2020 |
Intradialytic hypotension: beyond hemodynamics.
Topics: Aged; Aged, 80 and over; Aldosterone; Angiotensin-Converting Enzyme 2; Arginine; Biomarkers; Blood Pressure; Endothelin-1; Endothelium, Vascular; Female; Humans; Hypotension; Kidney Diseases; Male; Membrane Glycoproteins; Middle Aged; Peptidyl-Dipeptidase A; Renal Dialysis; Renin; Time Factors; Vascular Endothelial Growth Factor C | 2019 |
The detrimental effect of asymmetric dimethylarginine on cholesterol efflux of macrophage foam cells: Role of the NOX/ROS signaling.
Topics: Amidohydrolases; Animals; Arginine; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; Cholesterol; Cytokines; Enzyme Inhibitors; Foam Cells; Hyperlipidemias; Lipoproteins, LDL; Macrophages; Male; Mice; Mice, Knockout, ApoE; NADPH Oxidase 1; Reactive Oxygen Species; Triglycerides | 2019 |
Interleukin enhancement binding factor 3 inhibits cardiac hypertrophy by targeting asymmetric dimethylarginine-nitric oxide.
Topics: Amidohydrolases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arginine; Cardiomegaly; Down-Regulation; Gene Knockdown Techniques; Losartan; Male; Myocytes, Cardiac; Nitric Oxide; Nuclear Factor 90 Proteins; Rats, Sprague-Dawley | 2019 |
Young rats with increased circulatory asymmetric dimethylarginine exhibited spatial deficit and alterations in dorsal hippocampus brain-derived neurotrophic factor and asymmetric dimethylarginine: Effects of melatonin.
Topics: Animals; Arginine; Brain-Derived Neurotrophic Factor; Hippocampus; Male; Melatonin; Rats; Rats, Sprague-Dawley; Spatial Behavior | 2019 |
Targeted metabolomic analysis of nitric oxide/L-arginine pathway metabolites in dementia: association with pathology, severity, and structural brain changes.
Topics: Arginine; Biomarkers; Brain; Citrulline; Dementia; Female; Humans; Male; Metabolomics; Middle Aged; Nitric Oxide; Signal Transduction | 2019 |
Asymmetric dimethylarginine aggravates blood-retinal barrier breakdown of diabetic retinopathy via inhibition of intercellular communication in retinal pericytes.
Topics: Animals; Apoptosis; Arginine; Blood-Retinal Barrier; Cell Communication; Cell Membrane Permeability; Cells, Cultured; Connexin 43; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Gap Junctions; Glucose; Male; Pericytes; Rats; Rats, Sprague-Dawley; Streptozocin | 2019 |
Melatonin rescued methotrexate-induced spatial deficit and hyperhomocysteinemia and increased asymmetric dimethylarginine in plasma and dorsal hippocampus in developing rats.
Topics: Animals; Animals, Newborn; Antimetabolites, Antineoplastic; Arginine; Disease Models, Animal; Hippocampus; Hyperhomocysteinemia; Male; Maze Learning; Melatonin; Methotrexate; Rats; Rats, Sprague-Dawley; Spatial Behavior | 2020 |
Assessment of Endothelial Dysfunction with Methylated Arginines and L-arginine in Cadmium-Exposed People: a Pilot Study.
Topics: Adult; Arginine; Atherosclerosis; Cadmium; Chromatography, Liquid; Endothelium, Vascular; Environmental Pollutants; Humans; Hypertension; Male; Middle Aged; Occupational Exposure; Pilot Projects; Tandem Mass Spectrometry | 2019 |
Dimethylarginine Dimethylaminohydrolase 1 Polymorphisms and Venous Intimal Hyperplasia in Hemodialysis Patients.
Topics: Aged; Aged, 80 and over; Amidohydrolases; Arginine; Arteriovenous Shunt, Surgical; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Hyperplasia; Kidney Failure, Chronic; Male; Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies; Renal Dialysis; Tunica Intima; Veins | 2019 |
Changes in Water Soluble Uremic Toxins and Urinary Acute Kidney Injury Biomarkers After 10- and 100-km Runs.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Adult; Albuminuria; Arginine; Biomarkers; Creatinine; Female; Glomerular Filtration Rate; Humans; Lipocalin-2; Lipocalins; Male; Methylamines; Middle Aged; Running; Urea; Uric Acid; Water | 2019 |
Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis.
Topics: Animals; Aorta; Arginine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 Enzyme System; Female; Intramolecular Oxidoreductases; Kidney; Male; Mice, Knockout; PPAR-beta; Prostaglandin-E Synthases; Prostaglandins I; Receptors, Cytoplasmic and Nuclear; Receptors, Epoprostenol; Receptors, Prostaglandin E | 2020 |
Cell-Free Hemoglobin Is Associated With Increased Vascular Resistance and Reduced Peripheral Perfusion in Severe Malaria.
Topics: Adult; Arginine; Arterial Pressure; Bacteremia; Case-Control Studies; Echocardiography; Female; Hematocrit; Hemoglobins; Humans; Malaria, Falciparum; Male; Middle Aged; Nitric Oxide; Patient Acuity; Regional Blood Flow; Vascular Resistance; Young Adult | 2020 |
Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice.
Topics: Amidohydrolases; Animals; Anthocyanins; Aortic Valve Stenosis; Apoptosis; Arginine; Blueberry Plants; Cardiovascular Diseases; Disease Models, Animal; Gene Expression Regulation; Humans; Mice; Myocytes, Cardiac; Nitric Oxide; Oxidative Stress; Plant Extracts; Signal Transduction | 2020 |
Impact of zinc oxide nanoparticles on thioredoxin-interacting protein and asymmetric dimethylarginine as biochemical indicators of cardiovascular disorders in gamma-irradiated rats.
Topics: Animals; Arginine; Biomarkers; Cardiotoxicity; Cell Cycle Proteins; Cytokines; Dose-Response Relationship, Drug; Gamma Rays; Heart; Inflammation; Male; Nanoparticles; Oxidative Stress; Radiation Injuries, Experimental; Rats; Zinc Oxide | 2020 |
DDAH-2 alleviates contrast medium iopromide-induced acute kidney injury through nitric oxide synthase.
Topics: Acute Kidney Injury; Amidohydrolases; Animals; Arginine; Cell Line; Contrast Media; Female; Humans; Iohexol; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase; Rats; Reperfusion Injury | 2019 |
Iron Overload Damages the Endothelial Mitochondria
Topics: Amidohydrolases; Animals; Arginine; Human Umbilical Vein Endothelial Cells; Humans; Iron Overload; Mice; Mitochondria; Nitric Oxide; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Signal Transduction | 2019 |
ADMA elevation does not exacerbate development of diabetic nephropathy in mice with streptozotocin-induced diabetes mellitus.
Topics: Amidohydrolases; Animals; Arginine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glomerular Filtration Rate; Male; Mice; Mice, Inbred C57BL; Risk Factors; Streptozocin | 2019 |
Comparison of asymmetric dimethylarginine levels between pre- and post-menopausal women - a cross-sectional study from Rawalpindi.
Topics: Adult; Arginine; Cross-Sectional Studies; Female; Humans; Middle Aged; Pakistan; Postmenopause; Premenopause | 2019 |
Restoration of Adiponectin-Connexin43 Signaling Mitigates Myocardial Inflammation and Dysfunction in Diabetic Female Rats.
Topics: Adiponectin; Animals; Arginine; Connexin 43; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Estradiol; Estrogen Receptor alpha; Female; Heme Oxygenase (Decyclizing); Hypertrophy, Left Ventricular; Ovariectomy; Piperidines; Rats, Wistar; Receptors, Adiponectin; Receptors, G-Protein-Coupled; Signal Transduction; Tumor Necrosis Factor-alpha; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2020 |
Quercetin protects the vascular endothelium against iron overload damages via ROS/ADMA/DDAHⅡ/eNOS/NO pathway.
Topics: Amidohydrolases; Antioxidants; Apoptosis; Arginine; Cell Line; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Iron Overload; Mitochondria; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Quercetin; Reactive Oxygen Species; Signal Transduction | 2020 |
Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy.
Topics: Adenoviridae; Albuminuria; Amidohydrolases; Animals; Arginine; Cytokines; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibrosis; Genetic Therapy; Genetic Vectors; Inflammation Mediators; Kidney; Male; Mice, Inbred DBA; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Signal Transduction; Thiobarbituric Acid Reactive Substances | 2020 |
Homocysteine and Asymmetrical Dimethylarginine in Diabetic Rats Treated with Docosahexaenoic Acid-Loaded Zinc Oxide Nanoparticles.
Topics: Animals; Arginine; Cellulose; Diabetes Mellitus, Experimental; Docosahexaenoic Acids; Homocysteine; Hyperhomocysteinemia; Insulin; Insulin Resistance; Male; Metal Nanoparticles; Microscopy, Electron, Transmission; Nitric Oxide; Rats; Risk Factors; Zinc Oxide | 2020 |
Cardiovascular risk factors and the concentration of asymmetric dimethylarginine.
Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Middle Aged; Risk Factors | 2020 |
The Role of Reactive Oxygen Species and Nitric Oxide in the Inhibition of
Topics: Arginine; Catecholamines; Cell Line; Enzyme Inhibitors; Humans; Imidazolines; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Peptide Hydrolases; Reactive Oxygen Species; Trichophyton | 2020 |
Maternal serum levels of asymmetric dimethylarginine in normal and preeclamptic pregnancies.
Topics: Adult; Arginine; Case-Control Studies; Cross-Sectional Studies; Female; Fetal Growth Retardation; Humans; Maternal Serum Screening Tests; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Third; Young Adult | 2020 |
Tetramethylpyrazine alleviates iron overload damage in vascular endothelium via upregulating DDAHII expression.
Topics: Amidohydrolases; Apoptosis; Arginine; Cell Survival; Cells, Cultured; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Iron Overload; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Pyrazines; Reactive Oxygen Species | 2020 |
Dimethylarginine dimethylaminohydrolase-1 contributes to exercise-induced cardiac angiogenesis in mice.
Topics: Amidohydrolases; Animals; Arginine; Behavior, Animal; Coronary Vessels; Glycogen Synthase Kinase 3 beta; Heart; Male; Mice; Mice, Knockout; Models, Animal; Neovascularization, Physiologic; Nitric Oxide; Physical Conditioning, Animal; Proto-Oncogene Proteins c-akt; ras Proteins; Sedentary Behavior; Signal Transduction | 2020 |
Asymmetric dimethylarginine exacerbates cognitive dysfunction associated with cerebrovascular pathology.
Topics: Amyloid beta-Protein Precursor; Animals; Arginine; Cerebrovascular Disorders; Cognitive Dysfunction; Endothelium, Vascular; Enzyme Inhibitors; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic | 2020 |
Serum Apelin and Asymmetric Dimethylarginine Levels in Patients With Exfoliation Syndrome or Exfoliative Glaucoma.
Topics: Aged; Aged, 80 and over; Apelin; Arginine; Cross-Sectional Studies; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Exfoliation Syndrome; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmoscopy; Prospective Studies; Slit Lamp Microscopy; Tonometry, Ocular | 2020 |
Dihydromyricetin increases endothelial nitric oxide production and inhibits atherosclerosis through microRNA-21 in apolipoprotein E-deficient mice.
Topics: Amidohydrolases; Animals; Apolipoproteins E; Arginine; Atherosclerosis; Enzyme Activation; Flavonols; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipid Metabolism; Lipids; Liver; Male; Mice, Inbred C57BL; MicroRNAs; Nitric Oxide; Nitric Oxide Synthase Type III; Signal Transduction | 2020 |
Evaluation of asymmetric dimethylarginine as an inflammatory and prognostic marker in dogs with acute pancreatitis.
Topics: Animals; Arginine; Biomarkers; C-Reactive Protein; Cohort Studies; Dog Diseases; Dogs; Female; Lipase; Male; Pancreatitis; Prognosis; Systemic Inflammatory Response Syndrome | 2020 |
Asymmetric dimethylarginine and angiopoietin-like protein-2 are independent predictors of cardiovascular risk in pre-dialysis non-diabetic chronic kidney disease patients.
Topics: Adolescent; Adult; Angiopoietin-Like Protein 2; Angiopoietin-like Proteins; Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Predictive Value of Tests; Renal Insufficiency, Chronic; Risk Assessment; Young Adult | 2020 |
Circulating asymmetric dimethylarginine and cognitive decline: A 4-year follow-up study of the 1936 Aberdeen Birth Cohort.
Topics: Arginine; Cognitive Dysfunction; Follow-Up Studies; Humans; Nitric Oxide Synthase | 2020 |
Arginine derivatives in atrial fibrillation progression phenotypes.
Topics: Aged; Arginine; Atrial Fibrillation; Biomarkers; Cohort Studies; Disease Progression; Female; Homoarginine; Humans; Male; Middle Aged; Phenotype | 2020 |
Elevated plasma levels of asymmetric dimethylarginine and the risk for arrhythmic death in ischemic and non-ischemic, dilated cardiomyopathy - A prospective, controlled long-term study.
Topics: Aged; Arginine; Arrhythmias, Cardiac; Cardiomyopathy, Dilated; Case-Control Studies; Female; Heart Arrest; Humans; Male; Middle Aged; Myocardial Ischemia; Prospective Studies; Risk Factors; Ventricular Dysfunction, Left | 2020 |
Influence of Human Paraoxonase-1 Polymorphism (Q192R) on Serum Levels of Clinical Biomarkers Indicatives of Cardiovascular Diseases Risk in Mexican Women.
Topics: Adult; Arginine; Aryldialkylphosphatase; Biomarkers; Cardiovascular Diseases; Cross-Sectional Studies; Fatty Acid-Binding Proteins; Female; Genetic Predisposition to Disease; Heart Disease Risk Factors; Humans; Male; Mexico; MicroRNAs; Polymorphism, Genetic; Sex Factors | 2020 |
Increased symmetric dimethylarginine, but not asymmetric dimethylarginine, concentrations are associated with transient myocardial ischemia and predict outcome.
Topics: Aged; Arginine; Biomarkers; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Dipyridamole; Female; Follow-Up Studies; Heart; Heart Function Tests; Humans; Male; Middle Aged; Myocardial Perfusion Imaging; Prospective Studies; Risk Assessment; Tomography, X-Ray Computed | 2020 |
Asymmetric dimethylarginine and L-homoarginine prospectively relate to carotid wall thickness in a South African cohort.
Topics: Aged; Arginine; Black People; Blood Pressure; Carotid Intima-Media Thickness; Cohort Studies; Female; Homoarginine; Humans; Male; Middle Aged; Nitric Oxide; Prospective Studies; Ultrasonography | 2020 |
Comprehensive arginine metabolomics and peripheral vasodilatory capacity in rheumatoid arthritis: A monocentric cross-sectional study.
Topics: Aged; Aged, 80 and over; Arginine; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Citrulline; Cross-Sectional Studies; Female; Fingers; Homoarginine; Humans; Italy; Male; Metabolomics; Middle Aged; Vasodilation | 2020 |
Assessment of ADMA, IMA, and Vitamin A and E Levels in Patients with Acne Vulgaris.
Topics: Acne Vulgaris; Adolescent; Adult; Arginine; Biomarkers; Humans; Serum Albumin; Serum Albumin, Human; Vitamin A | 2020 |
Vectorial transport of the arginine derivatives asymmetric dimethylarginine (ADMA) and L-homoarginine by OATP4C1 and P-glycoprotein studied in double-transfected MDCK cells.
Topics: Animals; Arginine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dogs; Homoarginine; Humans; Madin Darby Canine Kidney Cells; Organic Anion Transporters; Transcytosis; Transfection | 2020 |
Evaluation of Plasma Asymmetric Dimethylarginine Levels and Abdominal Aortic Intima-Media Thickness in Infants of Smoker Mothers.
Topics: Adult; Aorta, Abdominal; Arginine; Case-Control Studies; Cigarette Smoking; Echocardiography; Female; Humans; Infant, Newborn; Male; Maternal Exposure; Mothers; Pregnancy; Prospective Studies; Smokers; Tunica Intima | 2021 |
Asymmetric dimethylarginine compartmental behavior during high-flux hemodialysis.
Topics: Adult; Arginine; Cardiovascular Diseases; Creatinine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Tandem Mass Spectrometry; Urea | 2020 |
Effect of high-altitude trekking on blood pressure and on asymmetric dimethylarginine and isoprostane production: Results from a Mount Ararat expedition.
Topics: Altitude; Arginine; Blood Pressure; Expeditions; Humans; Hypertension; Hypoxia; Isoprostanes; Male; Turkey | 2020 |
Renal asymmetric dimethylarginine inhibits fibrosis.
Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Fibronectins; Fibrosis; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Renal Insufficiency, Chronic; Ureteral Obstruction | 2020 |
The investigation of antioxidant and anti-inflammatory potentials of apitherapeutic agents on heart tissues in nitric oxide synthase inhibited rats via Nω-nitro-L-arginine methyl ester.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arginine; Aryldialkylphosphatase; Blood Pressure; Caffeic Acids; Free Radical Scavengers; Male; Myocardium; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidants; Oxidative Stress; Phenylethyl Alcohol; Pollen; Propolis; Rats; Rats, Sprague-Dawley | 2021 |
The effect of nitric oxide, endothelial nitric oxide synthetase, and asymmetric dimethylarginine in hemorrhoidal disease.
Topics: Arginine; Hemorrhoids; Humans; Nitric Oxide; Nitric Oxide Synthase Type III | 2020 |
[Asymmetric dimethylarginine (ADMA) in retinal vein occlusion-Results from the Gutenberg RVO study].
Topics: Aged; Arginine; Humans; Hypertension; Retinal Vein Occlusion; Risk Factors | 2021 |
ADMA (asymmetric dimethylarginine) and angiogenic potential in patients with type 2 diabetes and prediabetes.
Topics: Adult; Aged; Arginine; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Neovascularization, Physiologic; Prediabetic State; Solubility; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2021 |
Asymmetric dimethylarginine (ADMA) accelerates renal cell fibrosis under high glucose condition through NOX4/ROS/ERK signaling pathway.
Topics: Animals; Arginine; Cell Line; Cell Movement; Cell Proliferation; Cells, Cultured; Diabetic Retinopathy; Fibroblasts; Fibrosis; Glucose; Kidney; MAP Kinase Signaling System; Mesangial Cells; Models, Biological; NADPH Oxidase 4; Rats; Reactive Oxygen Species | 2020 |
Increased Intraplatelet ADMA Level May Promote Platelet Activation in Diabetes Mellitus.
Topics: Adenosine Diphosphate; Adult; Aged; Arginine; Blood Platelets; Calcium; Case-Control Studies; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Female; Humans; Male; Mass Spectrometry; Middle Aged; Nitric Oxide; Platelet Activation; Platelet Aggregation; Risk Factors | 2020 |
Pharmacologic downregulation of protein arginine methyltransferase1 expression by adenosine dialdehyde increases cell senescence in breast cancer.
Topics: Adenosine; Antineoplastic Combined Chemotherapy Protocols; Arginine; Betaine-Homocysteine S-Methyltransferase; Breast Neoplasms; Cell Cycle Checkpoints; Cell Proliferation; Cellular Senescence; Down-Regulation; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Methylation; Molecular Docking Simulation; Oxidative Stress; Phosphatidylethanolamine N-Methyltransferase; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Repressor Proteins; Signal Transduction; Tamoxifen | 2021 |
Association of Asymmetric Dimethylarginine and Nitric Oxide with Cardiovascular Risk in Patients with End-Stage Liver Disease.
Topics: Adult; Arginine; Cardiovascular Diseases; End Stage Liver Disease; Heart Disease Risk Factors; Humans; Nitric Oxide; Risk Factors; Severity of Illness Index | 2020 |
Serum asymmetric-dimethylarginine, apelin and NT-pro BNP levels in dialysis patients.
Topics: Adult; Aged; Apelin; Arginine; Biomarkers; Blood Pressure; Blood Pressure Determination; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Peritoneal Dialysis; Renal Dialysis | 2020 |
Asymmetric dimethylarginine-A potential cardiac biomarker in horses.
Topics: Animals; Arginine; Biomarkers; Enzyme-Linked Immunosorbent Assay; Female; Heart Diseases; Horse Diseases; Horses; Male; Prospective Studies; Reference Values | 2021 |
Evaluation of Biomarkers in Sepsis: High Dimethylarginine (ADMA and SDMA) Concentrations Are Associated with Mortality.
Topics: Arginine; Biomarkers; Humans; Sepsis | 2021 |
The shifted balance of arginine metabolites in acute myocardial infarction patients and its clinical relevance.
Topics: Arginine; Citrulline; Coronary Angiography; Female; Humans; Male; Middle Aged; Ornithine; Proline; ST Elevation Myocardial Infarction; Treatment Outcome | 2021 |
The Effect and Mechanism of Asymmetric Dimethylarginine Regulating Trophoblastic Autophagy on Fetal Growth Restriction.
Topics: Adenine; Adult; Arginine; Autophagy; Beclin-1; Cell Line, Tumor; Female; Fetal Growth Retardation; Humans; Matrix Metalloproteinase 9; Microtubule-Associated Proteins; Placenta; Pregnancy; Trophoblasts | 2021 |
Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting.
Topics: Animals; Arginine; Cachexia; Female; Heterografts; Humans; Male; Mice; Mice, Inbred C57BL; Mitochondria, Muscle; Muscle Proteins; Neoplasms; omega-N-Methylarginine | 2020 |
Intrathecal and systemic alterations of L-arginine metabolism in patients after intracerebral hemorrhage.
Topics: Aged; Arginine; Case-Control Studies; Cerebral Hemorrhage; Chromatography, High Pressure Liquid; Citrulline; Female; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Risk Factors; Tandem Mass Spectrometry; Up-Regulation | 2021 |
Lack of evidence of the correlation between plasma Asymmetrical Dimethylarginine correlation and IMT in type 2 diabetic patients with chronic vascular complication.
Topics: Adult; Aged; Arginine; Atherosclerosis; Carotid Artery, Internal; Carotid Intima-Media Thickness; Case-Control Studies; Chronic Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; Male; Middle Aged; Risk Factors; Ultrasonography, Doppler, Color | 2021 |
Is there a relation between serum methylarginine levels and infertility?
Topics: Adult; Arginine; Biomarkers; Disease Susceptibility; Humans; Infertility; Male; Oligospermia; ROC Curve; Semen Analysis; Sperm Count; Young Adult | 2021 |
Serum ADMA levels were positively correlated with EDSS scores in patients with multiple sclerosis.
Topics: Adult; Arginine; Female; Humans; Male; Multiple Sclerosis, Relapsing-Remitting; Nitric Oxide; Severity of Illness Index | 2021 |
Impact of combined elevations of homocysteine and asymmetric dimethylarginine on all-cause death - The Tanushimaru Study.
Topics: Arginine; Female; Homocysteine; Humans; Male; Middle Aged; Proportional Hazards Models; Regression Analysis | 2021 |
Altered methylarginine levels after surgery in subjects with multinodular goiter.
Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Goiter, Nodular; Humans; Male; Middle Aged; omega-N-Methylarginine; Postoperative Period; Sensitivity and Specificity | 2021 |
Relation of asymmetric dimethylarginine with pulmonary morbidities in neonatal respiratory distress syndrome.
Topics: Adolescent; Arginine; Humans; Infant, Newborn; Infant, Premature; Morbidity; Prospective Studies; Respiratory Distress Syndrome, Newborn | 2021 |
Whole-body arginine dimethylation is associated with all-cause mortality in adult renal transplant recipients.
Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Cause of Death; Female; Heart Disease Risk Factors; Humans; Kidney Transplantation; Male; Methylation; Middle Aged; Protein Processing, Post-Translational; Tissue Donors; Transplant Recipients | 2021 |
Clinically inapparent right heart dysfunction is associated with reduced myofilament force development in coronary artery disease.
Topics: Aged; Arginine; Asymptomatic Diseases; Biomarkers; C-Reactive Protein; Calcium; Coronary Artery Bypass; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Myocardial Contraction; Myofibrils; Serum Albumin, Human; Serum Amyloid P-Component; Treatment Outcome; Ventricular Dysfunction, Right; Ventricular Function, Right | 2021 |
Profile of new vascular damage biomarkers in middle-aged men with arterial hypertension.
Topics: Adult; Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Endothelium, Vascular; Follow-Up Studies; Humans; Hypertension; Male; Malondialdehyde; Middle Aged; Nitric Oxide; Prognosis | 2021 |
Maternal resveratrol therapy protected adult rat offspring against hypertension programmed by combined exposures to asymmetric dimethylarginine and trimethylamine-N-oxide.
Topics: Animals; Antioxidants; Arginine; Female; Gastrointestinal Microbiome; Hypertension; Methylamines; Pregnancy; Prenatal Exposure Delayed Effects; Prenatal Nutritional Physiological Phenomena; Rats; Renin-Angiotensin System; Resveratrol | 2021 |
Electrophoretic Determination of Symmetric and Asymmetric Dimethylarginine in Human Blood Plasma with Whole Capillary Sample Injection.
Topics: Acetonitriles; Anions; Arginine; Electric Conductivity; Electrophoresis, Capillary; Humans; Limit of Detection | 2021 |
Asymmetric dimethylarginine in psychiatric disorders.
Topics: Arginine; Bipolar Disorder; Female; Humans; Male; Psychotic Disorders; Schizophrenia | 2021 |
Association Between the Asymmetric Dimethylarginine Levels and Glaucoma Severity: A Cross-Sectional Analysis of the LIGHT Study.
Topics: Aged; Arginine; Biomarkers; Cross-Sectional Studies; Female; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Male; Severity of Illness Index | 2021 |
Endogenous asymmetric dimethylarginine accumulation precipitates the cardiac and mitochondrial dysfunctions in type 1 diabetic rats.
Topics: Acetylcysteine; Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Free Radical Scavengers; Glycosylation; Heart Diseases; Insulin Resistance; Male; Mitochondria; Myocardial Contraction; Myocytes, Cardiac; Nitric Oxide; Papillary Muscles; Rats, Sprague-Dawley; Signal Transduction; Streptozocin | 2021 |
Elevated serum SDMA and ADMA at hospital admission predict in-hospital mortality of COVID-19 patients.
Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Cohort Studies; COVID-19; Female; Hospital Mortality; Hospitalization; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Risk Factors; SARS-CoV-2 | 2021 |
Evaluation of serum neutrophil gelatinase-associated lipocalin (NGAL), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) levels, and their relations with disease type and activity in inflammatory bowel diseases
Topics: Adult; Aged; Arginine; Biomarkers; Colitis, Ulcerative; Crohn Disease; Female; Humans; Inflammatory Bowel Diseases; Lipocalin-2; Male; Middle Aged | 2021 |
Invited commentary for asymmetric dimethylarginine (ADMA): Is it a risk factor in the repair of aortic coarctation?
Topics: Aortic Coarctation; Arginine; Endothelium, Vascular; Humans; Risk Factors | 2021 |
Asymmetric dimethylarginine: Is it a risk facgtor in the repair of aortic coarctation?
Topics: Adult; Aorta; Aortic Coarctation; Arginine; Humans; Infant, Newborn; Nitric Oxide Synthase | 2021 |
Evaluation of Asymmetric Dimethylarginine Levels in Patients With Chronic Thromboembolic Pulmonary Hypertension Undergoing Pulmonary Endarterectomy.
Topics: Arginine; Chronic Disease; Endarterectomy; Humans; Hypertension, Pulmonary | 2022 |
The role of adrenergic and muscarinic receptors in stress-induced cardiac injury.
Topics: Animals; Arginine; Corticosterone; Female; Heart Injuries; Male; Natriuretic Peptide, Brain; Organ Size; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Muscarinic; Spleen; Stress, Physiological | 2021 |
Determination of serum methylarginine levels by tandem mass spectrometric method in patients with ankylosing spondylitis.
Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Female; Humans; Male; Spondylitis, Ankylosing; Tandem Mass Spectrometry | 2021 |
Resveratrol prevented spatial deficits and rescued disarrayed hippocampus asymmetric dimethylarginine and brain-derived neurotrophic factor levels in young rats with increased circulating asymmetric dimethylarginine.
Topics: Animals; Antioxidants; Arginine; Brain-Derived Neurotrophic Factor; Hippocampus; Male; Maze Learning; Rats; Rats, Sprague-Dawley; Resveratrol; Spatial Behavior | 2021 |
The Serum Levels of Asymmetric Dimethylarginine, Vascular Endothelial Growth Factor, and Insulin-Like Growth Factor-1 in Preterms with Retinopathy of Prematurity.
Topics: Arginine; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Insulin-Like Growth Factor I; Retinopathy of Prematurity; Vascular Endothelial Growth Factor A | 2022 |
Vascular and immunopathological role of Asymmetric Dimethylarginine (ADMA) in Experimental Autoimmune Encephalomyelitis.
Topics: Animals; Arginine; Blood-Brain Barrier; CD4-Positive T-Lymphocytes; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Mice; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Pertussis Toxin | 2021 |
A Cross-Talk between the Erythrocyte L-Arginine/ADMA/Nitric Oxide Metabolic Pathway and the Endothelial Function in Subjects with Type 2 Diabetes Mellitus.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Citrulline; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Endothelium, Vascular; Erythrocytes; Female; Humans; Male; Metabolic Networks and Pathways; Middle Aged; Nitric Oxide | 2021 |
Serum L-arginine and endogenous methylarginine concentrations predict irritable bowel syndrome in adults: A nested case-control study.
Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Case-Control Studies; Cohort Studies; Female; Humans; Irritable Bowel Syndrome; Logistic Models; Male; Middle Aged; Nitric Oxide; Odds Ratio; Psychological Distress; ROC Curve | 2021 |
Hyperuricemia induces endothelial dysfunction and accelerates atherosclerosis by disturbing the asymmetric dimethylarginine/dimethylarginine dimethylaminotransferase 2 pathway.
Topics: Amidohydrolases; Animals; Arginine; Atherosclerosis; Endothelial Cells; Humans; Hyperuricemia; Mice; Nitric Oxide | 2021 |
Comparative study of coronary artery bypass graft materials: reduced contraction and ADMA levels in internal mammary artery versus saphenous vein.
Topics: Arginine; Biomarkers; Coronary Artery Bypass; Humans; In Vitro Techniques; Mammary Arteries; Saphenous Vein; Vascular Patency; Vasoconstriction; Vasoconstrictor Agents | 2022 |
Associations of circulating dimethylarginines with the metabolic syndrome in the Framingham Offspring study.
Topics: Arginine; Biomarkers; Cross-Sectional Studies; Female; Humans; Male; Metabolic Syndrome; Middle Aged; Prevalence; Prospective Studies; Tandem Mass Spectrometry | 2021 |
Endothelial dysfunction biomarkers in sickle cell disease: is there a role for ADMA and PAI-1?
Topics: Adolescent; Adult; Anemia, Sickle Cell; Arginine; Biomarkers; Child; Cross-Sectional Studies; Endothelium; Female; Humans; Male; Plasminogen Activator Inhibitor 1; Severity of Illness Index; Young Adult | 2022 |
Cholecalciferol and metformin protect against lipopolysaccharide-induced endothelial dysfunction and senescence by modulating sirtuin-1 and protein arginine methyltransferase-1.
Topics: Antioxidants; Arginine; Cell Cycle Checkpoints; Cell Line; Cellular Senescence; Cholecalciferol; Endothelium; Homocysteine; Humans; Lipopolysaccharides; Metformin; Methylation; NAD; Nitric Oxide; Protective Agents; Protein-Arginine N-Methyltransferases; Repressor Proteins; S-Adenosylmethionine; Sirtuin 1; Telomerase; Vitamin D Response Element | 2021 |
Effect of profilin-1 on the asymmetric dimethylarginine-induced vascular lesion-associated hypertension.
Topics: Animals; Arginine; Cell Proliferation; Endothelium, Vascular; Humans; Hypertension; Myocytes, Smooth Muscle; Profilins; Rats | 2022 |
The Relationship of Thyroid Functions with ADMA, IMA, and Metabolic Laboratory Parameters in Euthyroid Adults with and without Autoimmune Thyroiditis.
Topics: Adult; Arginine; Biomarkers; Humans; Serum Albumin; Serum Albumin, Human; Thyroiditis, Autoimmune; Thyrotropin; Thyroxine | 2022 |
Dysregulated Arginine Metabolism in Young Patients with Chronic Persistent Asthma and in Human Bronchial Epithelial Cells.
Topics: Adult; Arginine; Asthma; Bronchi; Case-Control Studies; Cell Culture Techniques; Chronic Disease; Citrulline; Eosinophils; Epithelial Cells; Female; Humans; Male; Nitric Oxide; Ornithine; Prospective Studies; Young Adult | 2021 |
Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation.
Topics: Amidohydrolases; Animals; Arginine; Bone and Bones; Female; Hydrolysis; Male; Mechanical Phenomena; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteogenesis | 2022 |
Serum asymmetric dimethylarginine level correlates with the progression and prognosis of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Arginine; Biomarkers; Disease Progression; Humans; Nitric Oxide; Prognosis | 2022 |
Association of asymmetric dimethylarginine with the pathological process of persistent pulmonary hypertension of the newborn.
Topics: Arginine; Biomarkers; Humans; Hypertension, Pulmonary; Infant, Newborn; Prospective Studies | 2022 |
Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases.
Topics: Arginine; Asthma; Child; Dermatitis, Atopic; Female; Homoarginine; Humans; Male; Malondialdehyde; Nitrates; Nitric Oxide; Nitrites; Oxidative Stress; Signal Transduction | 2022 |
A Therapeutic Extracorporeal Device for Specific Removal of Pathologic Asymmetric Dimethylarginine from the Blood.
Topics: Animals; Arginine; Kidney Diseases; Swine | 2022 |
Design and validation of an LC-MS/MS method for simultaneous quantification of asymmetric dimethylguanidino valeric acid, asymmetric dimethylarginine and symmetric dimethylarginine in human plasma.
Topics: Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Female; Humans; Male; Non-alcoholic Fatty Liver Disease; Tandem Mass Spectrometry | 2022 |
Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling.
Topics: Amidohydrolases; Animals; Aorta; Arginine; Blood Pressure; Mice; Transaminases; Vascular Diseases | 2022 |
Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs.
Topics: Anticonvulsants; Arginine; Carotid Intima-Media Thickness; Child; Epilepsy; Homocysteine; Humans; Levetiracetam; Valproic Acid | 2022 |
Asymmetric Dimethylarginine Protects Neurons from Oxygen Glucose Deprivation Insult by Modulating Connexin-36 Expression.
Topics: Animals; Arginine; Cells, Cultured; Connexins; Glucose; L-Lactate Dehydrogenase; Neurons; Nitric Oxide; Oxygen; Rats | 2022 |
The ADMA-DDAH1 axis in ovarian apoptosis of polycystic ovary syndrome.
Topics: Amidohydrolases; Animals; Apoptosis; Arginine; Dehydroepiandrosterone; Female; Humans; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Signal Transduction | 2023 |
Asymmetric Dimethylarginine Is a Marker of Endothelial Dysfunction in Thrombotic Antiphospholipid Syndrome Patients.
Topics: Antiphospholipid Syndrome; Arginine; Biomarkers; C-Reactive Protein; Dilatation, Pathologic; Endothelium, Vascular; Humans; Nitroglycerin; Thrombosis; Vasodilation | 2022 |
Increased Plasma L-Arginine Levels and L-Arginine/ADMA Ratios after Twelve Weeks of Omega-3 Fatty Acid Supplementation in Amateur Male Endurance Runners.
Topics: Arginine; Dietary Supplements; Docosahexaenoic Acids; Fatty Acids, Omega-3; Humans; Male | 2022 |
Asymmetric Dimethylarginine as a Biomarker in Coronary Artery Disease.
Topics: Arginine; Atherosclerosis; Biomarkers; Coronary Artery Disease; Humans; Risk Factors | 2023 |
The role of asymmetric dimethylarginine in endothelial dysfunction and abnormal nitric oxide metabolism in systemic sclerosis: results from a pilot study.
Topics: Adult; Aged; Arginine; Atherosclerosis; Biomarkers; Carotid Intima-Media Thickness; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Nitric Oxide; Pilot Projects; Scleroderma, Systemic | 2023 |
Asymmetric Dimethylarginine in an NMU-induced Rat Mammary Tumor Model.
Topics: Animals; Arginine; Female; Rats; Rats, Sprague-Dawley | 2023 |
Association of serum ADMA, SDMA and L-NMMA concentrations with disease progression in COVID-19 patients.
Topics: Arginine; COVID-19; Disease Progression; Humans; omega-N-Methylarginine | 2023 |
Metabolite asymmetric dimethylarginine (ADMA) functions as a destabilization enhancer of SOX9 mediated by DDAH1 in osteoarthritis.
Topics: Animals; Arginine; Mice; Ubiquitin-Specific Peptidase 7 | 2023 |
Urinary excretion of asymmetric (ADMA) and symmetric (SDMA) dimethylarginine is positively related to nitric oxide level in tissues of normotensive and hypertensive rats.
Topics: Animals; Arginine; Chromatography, Liquid; Citrulline; Hypertension; Male; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tandem Mass Spectrometry | 2023 |
Arginine, symmetric and asymmetric dimethylarginine levels in canine leishmaniasis.
Topics: Animals; Arginine; Creatinine; Dogs; Kidney; Leishmaniasis | 2023 |
Association between asymmetric dimethylarginine and sarcopenia in community-dwelling older women.
Topics: Aged; Arginine; Female; Humans; Independent Living; Sarcopenia; Vascular Diseases | 2023 |
Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation.
Topics: Arginine; HEK293 Cells; Humans; Lipids; Nitric Oxide Synthase; Receptors, Calcium-Sensing | 2023 |
LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway.
Topics: Amidohydrolases; Animals; Arginine; Endothelial Cells; Fibrosis; Forkhead Box Protein O1; Glucose; Humans; Rats; RNA, Long Noncoding; Signal Transduction | 2023 |
Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study.
Topics: Arginine; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus; Diabetic Nephropathies; Heart Failure; Humans; Renal Insufficiency, Chronic | 2023 |
The effect of exenatide (a GLP-1 analogue) and sitagliptin (a DPP-4 inhibitor) on asymmetric dimethylarginine (ADMA) metabolism and selected biomarkers of cardiac fibrosis in rats with fructose-induced metabolic syndrome.
Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Chromatography, Liquid; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Fibrosis; Fructose; Glucagon-Like Peptide 1; Hypoglycemic Agents; Metabolic Syndrome; Nitric Oxide; Protease Inhibitors; Rats; Sitagliptin Phosphate; Tandem Mass Spectrometry | 2023 |
The role of asymmetric dimethylarginine (ADMA) in COVID-19: association with respiratory failure and predictive role for outcome.
Topics: Arginine; Biomarkers; COVID-19; Humans; Respiratory Insufficiency; RNA, Viral; SARS-CoV-2 | 2023 |