Page last updated: 2024-09-03

n,n-dimethylarginine and arginine

n,n-dimethylarginine has been researched along with arginine in 2107 studies

Compound Research Comparison

Studies
(n,n-dimethylarginine)
Trials
(n,n-dimethylarginine)
Recent Studies (post-2010)
(n,n-dimethylarginine)
Studies
(arginine)
Trials
(arginine)
Recent Studies (post-2010) (arginine)
2,2162281,22146,3881,68811,176

Protein Interaction Comparison

ProteinTaxonomyn,n-dimethylarginine (IC50)arginine (IC50)
Cationic amino acid transporter 3Homo sapiens (human)283

Research

Studies (2,107)

TimeframeStudies, this research(%)All Research%
pre-19908 (0.38)18.7374
1990's59 (2.80)18.2507
2000's716 (33.98)29.6817
2010's1187 (56.34)24.3611
2020's137 (6.50)2.80

Authors

AuthorsStudies
Fast, W; Hong, L1
Calver, A; Collier, J; Leone, A; Moncada, S; Vallance, P3
Lazarides, E; Lin, JM; Wang, C1
Kakimoto, Y; Kondoh, K; Kotani, K; Sano, A; Ueno, S1
Kakimoto, Y; Kotani, K; Sano, A; Ueno, S1
Busch, H; Cook, RG; Lischwe, MA; Ochs, RL; Reddy, R; Reichlin, M; Tan, EM; Yeoman, LC1
Kimoto, M; Ogawa, T; Sasaoka, K; Watanabe, H1
Christensen, ME; Fuxa, KP1
Kimoto, M; Ogawa, T; Sasaoka, K1
Amalric, F; Dumbar, TS; Ghaffari, SH; Lapeyre, B; Olson, MO; Rao, SV1
Ahn, YS; Busch, H; Cook, RG; Lischwe, MA; Yeoman, LC1
Nissim, I; Pereira, G; Segal, S; Yudkoff, M1
Fuchs, JP; Jacob, M; Judes, C1
Brian, JE; Faraci, FM; Heistad, DD1
MacAllister, RJ; Vallance, P; Whitley, GS1
Fickling, SA; MacAllister, RJ; Vallance, P; Whitley, GS1
Aneman, A; Backman, V; Fändriks, L; Pettersson, A; Snygg, J; von Bothmer, C1
Granger, DN; Grisham, MB; Kurose, I; Wolf, R1
Kim, S; Lee, YJ; Paik, WK; Park, JO; Rawal, N; Whitaker, JN1
Aswad, DW; Johnson, BA; Najbauer, J; Young, AL1
Fickling, SA; Nussey, SS; Vallance, P; Whitley, GS; Williams, D1
Li, YJ; Xiong, Y; Yu, XJ1
Bennett, T; Gardiner, SM; Kemp, PA; Moncada, S; Palmer, RM1
Arese, M; Bosia, A; Bussolino, F; Costamagna, C; Ghigo, D; MacAllister, R; Ruva, C; Strasly, M; Tetta, C; Verzetti, G1
Barefield, D; Ram, S; White, R; Work, J1
Bode-Böger, SM; Böger, RH; Frölich, JC; Junker, W; Kienke, S1
Ellory, JC; Lane, C; Mendes Ribeiro, AC; Roberts, NB; Yaqoob, M1
Brennecke, SP; Di Iulio, JL; Gude, NM; King, RG1
D'Alecy, LG; Jin, JS1
Hoffmann, KH; MacAllister, RJ; Rambausek, MH; Ritz, E; Vallance, P; Williams, D1
Imaizumi, T; Itoh, S; Iwami, G; Kimoto, M; Kohno, K; Matsuoka, H; Okuda, S; Tamai, O; Wada, Y; Yasukawa, H1
Hecker, M; Meyer, J; Richter, N1
Alexander, K; Bode-Böger, SM; Böger, RH; Frölich, JC; Junker, W; Thiele, W1
Kim, S; Kumar, A; Merrill, BM; Paik, WK; Papov, VV; Rajpurohit, R; Schneiders, JM; Stone, KL; Szer, W; Williams, KR; Wilson, SH1
Azuma, H; Hamasaki, H; Isotani, E; Masuda, H; Obayashi, S; Sato, J; Tamaoki, S; Udagawa, T1
Backman, V; Pettersson, A; Uggla, L1
Chen, BM; Xia, LW; Zhao, RQ1
Azuma, H; Masuda, H; Niwa, K; Sato, J; Tokoro, T1
Dillon, MJ; Frend, A; Goonasekera, CD; Rees, DD; Shah, V; Woolard, P1
Anderstam, B; Bergström, J; Katzarski, K1
Bode-Böger, SM; Böger, RH1
Herlitz, H; Petersson, A; Sigström, L; Wennmalm, A; Westberg, G1
Bremer, V; Kimoto, M; Kimura, K; Ogawa, T; Omata, M; Tojo, A; Vallance, P; Welch, WJ; Wilcox, CS1
Frölich, JC; Junker, W; Tsikas, D1
Imaizumi, T; Matsuoka, H; Miyazaki, H; Okuda, S; Ueda, S; Usui, M1
Arnold, JM; Feng, Q; Fortin, AJ; Hedner, T; Kline, RL; Lu, X; Pettersson, A1
Kim, S; Lee, HW; Lim, IK; Paik, WK; Park, TJ1
Li, NS; Li, YJ; Liu, GZ; Xiong, Y; Yu, XJ1
Blaschke, TF; Bode-Böger, SM; Böger, RH; Chan, JR; Cooke, JP; Szuba, A; Tangphao, O; Tsao, PS1
Azuma, H; Hamasaki, H; Ishizaka, K; Masuda, H; Matsubara, O; Sato, J; Tamaoki, S1
Kelly, JJ; Lawson, J; Tam, SH; Whitworth, JA; Williamson, PM1
Alexander, K; Bode-Böger, SM; Böger, RH; Creutzig, A; Frölich, JC; Thiele, W1
Barnes, PJ; Cole, PJ; Dowling, RB; Newton, R; Robichaud, A; Wilson, R1
Acchiardo, SR; Cardenas, R; Chiang, TM; Kang, ES; Myers, LK; Tevlin, MT; Wang, YB1
Azuma, H; Goto, M; Masuda, H; Tamaoki, S1
Cooke, JP; Imaizumi, T; Matsuoka, H; Miyazaki, H; Okuda, S; Ueda, S; Usui, M2
Barbey, M; Bode-Böger, SM; Böger, RH; Frölich, JC; Kielstein, JT; Koch, KM; Schäffer, J1
Brand, R; Egberts, J; van den Bosch, N1
Deng, HW; Li, YJ; Lu, R; Xiong, Y1
Cartwright, JE; Holden, DP; Whitley, GS1
Aldasoro, M; Ballester, RM; Lluch, P; Lluch, S; Medina, P; Pelligrino, DA; Segarra, G; Vila, JM1
Cartwright, JE; Fickling, SA; Holden, DP; Nussey, SS; Vallance, P; Whitley, GS1
Egberts, J; Soederhuizen, P; van den Bosch, N1
Azuma, H1
Leiper, J; Vallance, P3
Fujiwara, N; Kamada, T; Katoh, T; Okumura, K; Osanai, T; Takahashi, K1
Bode-Böger, SM; Böger, RH; Cooke, JP; Imaizumi, T; Matsuoka, H; Miyazaki, H; Okuda, S; Ueda, S; Usui, M1
Al Banchaabouchi, M; D'Hooge, R; De Deyn, PP; Levillain, O; Marescau, B; Possemiers, I1
Blaschke, TF; Bode-Böger, SM; Böger, RH; Chan, JR; Cooke, JP; Tangphao, O; Tsao, PS1
Johnstone, AP; Millatt, LJ; Nussey, SS; Whitley, GS1
Arnal, JF; Bayle, C; Caussé, E; Couderc, F; Malatray, P; Salvayre, R; Siri, N; Valdiguié, P1
Bode-Böger, SM; Böger, RH; Heistad, DD; Lentz, SR; Sydow, K1
Dillon, MJ; Goonasekera, CD; Rees, DD; Shah, V1
Bode-Böger, SM; Böger, RH; Borlak, J; Lenzen, H; Schubert, B; Sydow, K; Thum, T; Tsikas, D1
Bode-Böger, SM; Böger, RH; Frölich, JC; Sandmann, J; Tsikas, D1
Kimura, K; Masuyama, Y; Nishio, I; Tsuda, K1
Berglund, L; Bryant, TA; Cannon, PJ; Chen, NT; Di Tullio, MR; Donis, JA; Fard, A; Ginsberg, HN; Homma, S; Ramasamy, R; Sciacca, R; Torres-Tamayo, M; Tuck, CH; Wu, HD1
Duan, J; Ikeda, H; Imaizumi, T; Katoh, A; Kawata, H; Murohara, T; Sasaki, K; Shintani, S; Yamamoto, N1
Bode-Böger, SM; Böger, RH; Frölich, JC; Haller, H; Kielstein, JT1
Fleck, C; Janz, A; Karge, E; Schweitzer, F; Schwertfeger, M; Stein, G1
Beck, W; Deppisch, RM; Pommer, W; Riedel, E; Schröder, M1
Vallance, P1
Bode-Böger, SM; Böger, RH; Haynes, WG; Knapp, HR; Lentz, SR1
Acchiardo, SR; Cates, TB; Kang, ES; Miles, DE; Tevlin, MT1
Baylis, C; Schmidt, RJ; Wagner, L; Xiao, S1
Cooke, JP; Oka, RK1
Fiehn, W; Gorenflo, M; Ulmer, HE; Werle, E; Zheng, C1
Aswad, DW; Bunick, GJ; Chen, D; Hanson, BL; Harp, JM; Henschen-Edman, A; Koh, SS; Mackay, DR; Schurter, BT; Stallcup, MR1
Abbs, I; Dalton, RN; Denton, M; Swaminathan, R; Turner, C; Wahbi, N1
Dreyfuss, G; Friesen, WJ; Massenet, S; Paushkin, S; Wyce, A1
Kimura, K; Masuyama, Y; Nishio, I; Shimamoto, Y; Tsuda, K1
Branscombe, TL; Clarke, S; Cook, JR; Frankel, A; Lee, JH; Pestka, S; Yang , Z1
Bengtsson, A; Ellis, J; Hagberg, H; Lilja, H; Pettersson, A; Sultan, B; Wennergren, M; Wennerholm, UB1
Cooke, JP; Eriksson, MJ; Hamsten, A; Lundman, P; Stühlinger, M; Tornvall, P1
Kimura, K; Kinoshita, Y; Masuyama, Y; Nishio, I; Tsuda, K1
Bode-Böger, SM; Böger, RH; Chowienczyk, PJ; Fisher, I; Jackson, G; McGing, E; Ritter, JM; Walker, HA1
Fliser, D; Frölich, JC; Haller, H; Kielstein, JT1
Chen, BM; Deng, HW; Li, YJ; Xiong, Y; Yuan, LW1
Lee, SC; Yoo, JH1
Abe, T; Isobe, C; Murata, T; Sato, C; Tohgi, H1
Chen, QQ; Deng, HW; Jiang, CH; Li, YJ; Qu, XP; Quarles, LD; Xiao, ZS; Yu, YH; Zhou, HH1
Abbasi, F; Asagmi, T; Cooke, JP; Lamendola, C; McLaughlin, T; Reaven, GM; Stuehlinger, M; Tsao, PS1
Dreyfuss, G; Friesen, WJ; Mann, M; Massenet, S; Paushkin, S; Pesiridis, GS; Rappsilber, J; Van Duyne, G; Wyce, A1
Balint, RF; Cooke, JP; Her, JH; Kimoto, M; Stühlinger, MC; Tsao, PS1
Bode-Böger, SM; Böger, RH; Fliser, D; Frölich, JC; Haller, H; Kielstein, JT; Ritz, E1
Aso, T; Azuma, H; Beppu, M; Goto, M; Obayashi, S1
Benedetto, FA; Böger, R; Maas, R; Mallamaci, F; Salvatore Malatino, L; Tripepi, G; Zoccali, C1
Blandon, P; Jones, KL; Levi, M; Raj, DS; Robbins, RA; Sato, E; Shah, V; Simpson, K; Vincent, B; Welbourne, TC; Zager, P1
Jaimes, EA; Leclercq, B; Raij, L1
Azuma, H; Masuda, H1
Deng, HW; Jiang, JL; Li Ns, NS; Li, YJ1
Henrion, D; Lévy, BI; Loufrani, L; Matrougui, K1
Maxwell, AJ1
Abbasi, F; Chu, JW; Cooke, JP; Lamendola, C; McLaughlin, TL; Reaven, GM; Stühlinger, MC; Tsao, PS1
Nash, DT1
Decking, UK; Fingas, CD; Janosi, RA; Laussmann, T; Schlack, W; Schlieper, GR; Schrader, J1
de Jong, S; Nijveldt, RJ; Teerlink, T; van Leeuwen, PA1
Azuma, H; Goto, M; Kihara, K; Masuda, H; Okuno, T; Tsujii, T2
Achan, V; Arrigoni, F; Leiper, JM; Tran, CT; Vallance, P; Whitley, GS1
Edebo, A; Fändriks, L; Lönroth, H; Olbe, L; Pettersson, A; von Bothmer, C1
Cooke, JP; Losordo, DW1
Abbasi, F; Asagami, T; Cooke, JP; Lamendola, C; McLaughlin, T; Reaven, GM; Stuelinger, M; Tsao, PS1
Bellanuova, I; Benedetto, FA; Böger, R; Cataliotti, A; Maas, R; Malatino, LS; Mallamaci, F; Tripepi, G; Zoccali, C1
Cardounel, AJ; Zweier, JL1
Hu, CP; Li, YJ; Liao, EY; Lu, R; Wu, XP1
Baylis, C; Couser, W; Erdely, A; Riggleman, A; Wagner, L1
Delles, C; Gekle, M; John, S; Schmieder, RE; Schneider, MP1
Martinez, AC; Mulvany, MJ; Simonsen, U; Stankevicius, E1
Adimoolam, S; Asagami, T; Cooke, JP; Ito, A; Kimoto, M; Lin, KY; Reaven, GM; Tsao, PS; Tsuji, H1
Fujii, M; Kinoshita, M; Matsumoto, T; Ohnishi, M; Takayama, T; Tsutamoto, T; Wada, A; Wang, X; Yamamoto, T1
Blomberg, M; de Jong, S; Mulder, C; Scheltens, P; Teerlink, T; van Kamp, GJ; Wahlund, LO1
Fujiwara, N; Nakamura, M; Okumura, K; Osanai, T; Osawa, H; Saitoh, M; Sasaki, S; Tomita, H; Yamabe, H1
Zoccali, C6
Egashira, K; Ito, A; Muramatsu, K; Narishige, T; Takeshita, A1
Hansson, L; Hedner, T; Himmelmann, A1
Kautzky-Willer, A; Mayer, BX; Meyer, A; Mittermayer, F; Pacini, G; Wagner, OF; Winzer, C; Wolzt, M1
Knuuti, J; Laakso, J; Laaksonen, R; Laine, H; Päivä, H; Raitakari, OT1
Chang, MS; Chen, JW; Hsu, NW; Lin, SJ; Wu, TC1
Nijveldt, RJ; Rauwerda, JA; Stehouwer, CD; Teerlink, T; Van Guldener, C; Van Leeuwen, PA1
Aagaard, E; Andreassen, AK; Aukrust, P; Frøland, SS; Gullestad, L; Haugstad, TS; Holm, T; Kjekshus, J; Simonsen, S; Ueland, T1
Hermenegildo, C; Lluch, S; Medina, P; Ortega, J; Peiró, M; Segarra, G; Vila, JM1
Chan, JC; Chan, NN1
Arakawa, N; Bode-Böger, SM; Böger, RH; Frölich, JC; Hornig, B; Schwedhelm, E; Sydow, K; Tsikas, D1
Li, NS; Li, YJ; Lu, R; Peng, J; Zhu, HQ1
Barrigón, S; Boscá, L; Calleja, J; Callejas, NA; Casado, M; Dulin, E; Garutti, I; Martín-Sanz, P; Olmedilla, L; Pérez-Peña, J; Sanz, J1
Chan, JC; Chan, NN; Chan, WB1
Maeda, T; Okamura, H; Yoshimura, T1
Arnesen, H; Eid, HM; Eritsland, J; Larsen, J; Seljeflot, I1
Isomustajärvi, M; Laakso, J; Laaksonen, R; Lehtimäki, T; Päivä, H; Ruokonen, I1
Chierchia, S; Fermo, I; Fragasso, G; Galluccio, E; Lucotti, P; Margonato, A; Monti, LD; Paroni, R; Piatti, P; Pozza, G; Setola, E1
Nijveldt, RJ; Rauwerda, JA; Siroen, MP; Teerlink, T; van Lambalgen, AA; van Leeuwen, PA1
Kuik, DJ; Nijveldt, RJ; Rauwerda, JA; Siroen, MP; Teerlink, T; Van Der Hoven, B; van Leeuwen, PA1
Nijveldt, RJ; Teerlink, T; van Leeuwen, PA1
Imaizumi, T; Kato, S; Kimoto, M; Matsuoka, H; Morimatsu, M; Okuda, S; Ueda, S1
Chen, BM; Tao, LJ; Zhang, WR1
Arrigoni, FI; Haworth, SG; Leiper, JM; Vallance, P1
de Jong, S; Neele, SJ; Netelenbos, JC; Stehouwer, CD; Teerlink, T1
Aukrust, P; Haugstad, TS; Holm, T; Holven, KB; Nenseter, MS; Ose, L1
Laakso, J; Laaksonen, R; Lehtimäki, T; Päivä, H; Pasternack, A; Rantalaiho, V; Ruokonen, I; Wirta, O1
Cooke, JP; Weis, M1
Aizawa, Y; Hori, T; Ishibashi, T; Kubota, K; Matsubara, T; Mezaki, T; Nakamura, Y; Nasuno, A; Nishio, M; Ozaki, K; Tanaka, T; Tsuchida, K; Yamazoe, M1
Bode-Böger, SM; Fliser, D; Frölich, JC; Haller, H; Kielstein, JT; Ritz, E1
McGrath, BP; Teede, HJ1
Bode-Böger, SM; Fliser, D; Haller, H; Kielstein, JT2
Bode-Böger, SM; Fliser, D; Graf, S; Haller, H; Kielstein, JT; Klein, G1
John, S; Schmieder, RE1
Frölich, JC; Hingorani, AD; Nicolaides, KH; Savvidou, MD; Tsikas, D; Vallance, P1
Hörl, WH1
Bonfigli, AR; Coppa, G; Gambini, A; Marra, M; Testa, I; Testa, R1
Abdalla, DS; Bersch, D; Bertolami, MC; Faludi, AA; Pereira, EC; Salem, M1
Achan, V; Broadhead, M; Leiper, J; MacAllister, R; Malaki, M; Vallance, P; Whitley, G1
Fujita, M; Hori, M; Kitakaze, M; Nanto, S; Node, K1
Hedner, T; Hultberg, B; Jonasson, TF; Ohlin, H1
Billecke, SS; Demady, DR; Dunbar, AY; Everett, AC; Kamada, Y; Lowe, ER; Osawa, Y1
Anderson, DE; Cooke, JP; Fleg, JL; Lakatta, EG; Scuteri, A; Stuehlinger, MC; Wright, JG1
Brook, R; Chakrabarti, A; D'Alecy, LG; Kaplan, MJ; Kehrer, C; Mukherjee, D; Pavlic, R; Pfenninger, D; Rajagopalan, S; Somers, E1
Fu, SH; Fu, YF; Xiong, Y; Zhou, HH1
Cooke, JP; Graf, EE; Kapoor, O; Malinow, MR; Oka, RK; Pachinger, O; Schmölzer, I; Stühlinger, MC; Szuba, A; Upson, BM; Wascher, TC1
Anthony, S; Arrigoni, FI; Birdsey, GM; Leiper, JM; Smith, CL; Vallance, P1
Selley, ML1
Carey, RM; Johns, RA; Leiper, JM; Li, D; Millatt, LJ; Siragy, HM; Whitley, GS1
Cartwright, JE; Holden, DP; Nussey, SS; Whitley, GS1
Kenemans, P; Post, MS; Stehouwer, CD; Teerlink, T; van der Mooren, MJ; Verhoeven, MO1
Busch, M; Fleck, C; Karge, E; Schweitzer, F; Stein, G1
Cooke, JP5
Cynober, L1
Becker, T; Frölich, JC; Klempnauer, J; Nashan, B; Rode, I; Tsikas, D1
Hanada, H; Ishizaka, H; Kamada, T; Matsunaga, T; Okumura, K; Osanai, T; Saitoh, M1
Abdulhayoglu, E; Barbato, D; Bustami, R; D'Alecy, LG; Desai, A; Handelman, GJ; Novak, JE; Rajagopalan, S; Saran, R; Warren, JS; Weitzel, W1
Böger, RH9
Matsunaga, T; Okumura, K; Osanai, T; Saitoh, M; Sasaki, S; Tomita, H1
Charng, MJ; Ding, YA; Lin, SJ; Lu, TM1
Ding, YA; Lee, WS; Lin, SJ; Lu, TM; Tai, HC1
Brattström, L; Brudin, L; Hultberg, B; Teerlink, T; Wanby, P1
Nijveldt, RJ; Prins, HA; Rauwerda, JA; Stehouwer, CD; Teerlink, T; van Guldener, C; van Lambalgen, AA; van Leeuwen, PA1
Deng, HW; Jiang, JL; Li, YJ; Lu, R; Zhang, XH; Zhu, HQ1
Magota, K; Murakami, S; Nakamura, M; Okumura, K; Osanai, T; Osawa, H; Saitoh, M; Sasaki, S; Tomita, H; Yamabe, H1
Achan, V; Adimoolam, S; Cooke, JP; Dayoub, H; Jacobi, J; Kimoto, M; Patterson, AJ; Stuehlinger, MC; Tsao, PS; Vallance, P; Wang, BY1
Bode-Böger, SM; Fliser, D; Frölich, JC; Haller, H; Hoeper, MM; Impraim, B; Kielstein, JT; Simmel, S; Tsikas, D1
Böger, RH; Cooke, JP; Vallance, P2
Isomustajärvi, M; Laakso, J; Laaksonen, R; Lakka, TA; Lehtimäki, T; Päivä, H; Ruokonen, I; Salonen, JT; Valkonen, VP1
Böger, RH; Zoccali, C1
Böger, RH; Hanefeld, C; Mügge, A1
Leiper, JM; Tran, CT; Vallance, P1
Münzel, T; Sydow, K1
Dayal, S; Lentz, SR; Rodionov, RN1
Mallamaci, F; Tripepi, G; Zoccali, C1
Cooke, JP; Gao, SZ; Kledal, TN; Lin, KY; Mocarski, ES; Panchal, SN; Valantine, HA; Weis, M1
Ritz, E1
Mittermayer, F; Namiranian, K; Pleiner, J; Schaller, G; Wolzt, M1
Böger, R; Maas, R; Malatino, L; Mallamaci, F; Tripepi, G; Zoccali, C1
Faraci, FM; Lentz, SR1
Nishio, I; Tsuda, K7
Böger, RH; Casas, JP; Díaz, LA; López-Jaramillo, P; Maas, R; Schwedhelm, E; Serrano, N1
Janatuinen, T; Knuuti, J; Laakso, J; Laaksonen, R; Lehtimäki, T; Nuutila, P; Raitakari, OT; Vesalainen, R1
Goligorsky, MS; Sawamura, T; Smirnova, IV1
Goligorsky, MS; Kajstura, M; Sawamura, T; Smirnova, IV1
Bode-Böger, SM; Dierkes, J; Luley, C; Martens-Lobenhoffer, J; Westphal, S1
Dietz, S; Faurie, F; Gross, R; Lajoix, AD; Linck, N; Mani, JC; Petit, P; Pugnière, M; Ribes, G; Roquet, F1
Kurabayashi, M; Morita, H; Nagai, R; Nakamura, T; Saito, Y1
Hirata, Y2
Boucher, JL; Brunet, A; David-Dufilho, M; Devynck, MA; Millanvoye, E; Rendu, F; Topal, G1
Azuma, H; Kihara, K; Kurosaki, E; Masuda, H; Sakai, Y; Yamauchi, Y1
Brook, JR; Brook, RD; D'Alecy, LG; Dvonch, JT; Harkema, JR; Keeler, GJ; Marsik, FJ; Morishita, M; Rajagopalan, S; Timm, EJ; Wagner, JG; Yip, FY1
Deng, HW; Jiang, DJ; Jiang, JL; Li, NS; Li, YJ; Tang, YH1
Condorelli, M; de Nigris, F; Ignarro, LJ; Liguori, A; Napoli, C; Pignalosa, O; Sica, V1
Hayashida, Y; Morishita, T; Nakashima, Y; Nakata, S; Sasaguri, Y; Suda, O; Tasaki, H; Toyohira, Y; Tsujimoto, T; Tsutsui, M; Ueno, S; Ueta, Y; Yanagihara, N1
Achan, V1
Del Olmo, JA; Lluch, P; Medina, P; Rodrigo, JM; Segarra, G; Serra, MA; Torondel, B1
Dai, Z; Deng, HW; Jiang, DJ; Jiang, JL; Li, YJ; Zhu, HQ1
Beckmann, B; Bode-Böger, SM; Borlak, J; Martens-Lobenhoffer, J; Scalera, F; Täger, M; Thum, T1
McCarty, MF1
Bode-Böger, SM; Böger, RH; Frölich, JC; Phivthong-Ngam, L; Schwedhelm, E; Tsikas, D1
Fujii, H; Hiuge, A; Horio, T; Kamide, K; Kawano, Y; Nakatani, S; Ogihara, T; Rakugi, H; Takiuchi, S1
Laaksonen, R; Valkonen, VP1
Cohen, JJ; Harrington, JT; Hörl, WH; Madias, NE; Zusman, CJ1
Nijveldt, RJ; Siroen, MP; Teerlink, T; van Leeuwen, PA1
Bode-Böger, SM; Krug, O; Martens-Lobenhoffer, J1
Yoshizumi, M1
Arakawa, N; Bode-Böger, SM; Böger, RH; Hornig, B; Münzel, T; Sydow, K; Tsikas, D1
Krywawych, S; Petros, AJ; Pierce, CM1
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Malden, DE; Mangoni, AA; McNeil, C; Murray, AD; Soiza, RL; Thies, F; Woodman, RJ1
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Bahls, M; Böger, RH; Büttner, P; Hindricks, G; Kornej, J; Schwedhelm, E; Thiele, H1
Burger, AL; Demyanets, S; Diedrich, A; Pezawas, T; Stojkovic, S; Wojta, J1
Ochoa-Martínez, ÁC; Orta-García, ST; Pérez-Maldonado, IN; Varela-Silva, JA1
Bartha, E; Molnar, T; Nagy, L; Szabo, Z1
Chen, F; Guo, Q; Huang, Z; Lin, J; Liu, H; Xu, J; Yao, Q; Zhang, Z1
Böger, RH; Botha-Le Roux, S; Fourie, CMT; Mels, CMC; Mokhaneli, MC; Schwedhelm, E1
Bassu, S; Carru, C; Castagna, F; Erre, GL; Mangoni, AA; Passiu, G; Piga, M; Sotgia, S; Zinellu, A1
Abusoglu, S; Akyurek, F; Ataseven, A; Kurku, H; Saylam Kurtipek, G; Tunçez Akyürek, F; Unlu, A1
Fromm, MF; Gessner, A; König, J; Maas, R; Taghikhani, E; Taudte, RV1
Corrêa, HL; Costa, F; de Melo, GF; Deus, LA; Haro, AS; Honorato, FS; Moraes, MR; Moura, SRG; Neves, RVP; Prestes, J; Rosa, TS; Silva, JAB; Simões, HG; Souza, MK; Stone, W; Tzanno-Martins, C; Vieira, EC1
Arslan, D; Deniz, CD; Gunenc, O; Ozcelik, HS; Uysal, C; Vatansev, H1
Guo, L; Lian, B; Liao, P; Lu, H; Pan, W; Zhang, M1
Du, Q; Gao, J; Jin, Y; Lu, R; Yan, Y; Yu, C; Zou, Y1
Bhandari, S; Brunetti, L; Ferrante, C; Orlando, G; Parati, G; Soranna, D; Verratti, V; Zambon, A1
Huang, D; Tan, B; Wang, C; Wang, Y; Wu, M; Ye, C; Yuan, M; Zou, Y1
Gulhan, MF; Ozdemir, B; Sahna, E; Selamoglu, Z1
Appel, D; Böger, R; Goetz, AE; Hannemann, J; Heinze, G; Windolph, J1
Doi, Y; Fukae, S; Ikeda, S; Kawano, H; Koga, S; Maemura, K; Minami, T; Nakata, T; Tsuneto, A; Yonekura, T1
Durmus, S; Ersoz, F; Gelisgen, R; Gokce, AH; Gokce, FS; Hajiyeva, R; Uzun, H1
Binder, H; Closs, EI; Gericke, A; Habermeier, A; Pfeiffer, N; Ponto, KA; Rosner, AK; Scharrer, I1
Bergia, RE; Campbell, WW; Kim, JE; Roseguini, BT1
Balasubramanyam, M; Jayachandran, I; Manickam, N; Mohan, V; Paadukaana, S; Sundararajan, S; Venkatesan, S1
Alper, AB; Bodana, S; Bokhari, SR; Bundy, JD; Chandra, S; Chen, CS; Chen, J; Guo, Y; Hamm, LL; He, H; He, J; Hernandez, J; Kleinpeter, M; Kumbala, DR; Livingston, T; Lukitsch, I; Lustigova, E; Mahone, E; Nieman, DC; Obst, K; Schaefer, CM; Starcke, CC; Vadalia, AM1
Doroszko, A; Fortuna, P; Gajecki, D; Gawryś, J; Gawryś, K; Leśniewska, J; Majda, F; Mlynarz, P; Szahidewicz-Krupska, E; Wiśniewski, J1
Al-Dhabi, NA; Arasu, MV; Arockiaraj, J; Arshad, A; Charles, S; Madhavan, T; Mala, K; Munusamy-Ramanujam, G; Saraswathi, NT; Singh, P1
López, V; Moraga, FA; Uribe, E1
Batista, MC; de Oliveira Beraldo, D; Quinto, BMR; Rodrigues, CJ1
Dragičević, M; Košuta, I; Kruezi, E; Lovrenčić, MV; Mrzljak, A1
Bentli, R; Dogan, A; Taskapan, H; Taskapan, MC1
Bollinger, L; Ertelt, A; Gehlen, H; Kuban, S; Liertz, S; Merle, R; Stumpff, F1
Lynch, KL; van Wijk, XMR; Yun, C1
Carru, C; Cauli, A; Erre, GL; Mangoni, AA; Paliogiannis, P; Piga, M; Pintus, G; Sotgia, S; Tommasi, S; Zinellu, A1
Molek, P; Nessler, J; Wlodarczyk, A; Zalewski, J; Zmudzki, P1
Chen, Y; Dai, Y; Gao, Y; He, X; Li, TH; Yan, SB1
Berent, TE; Dorschner, JM; Jatoi, A; Kumar, R; Kunz, HE; Lanza, IR; Meyer, T; Wang, X1
Appel, D; Böger, R; Czorlich, P; Haddad, M; Hannemann, J; Lamszus, K; Mader, MM; Mohme, M; Schwedhelm, E; Westphal, M1
Adamiec, R; Dumas, I; Fiodorenko-Dumas, Z; Małecki, R; Paprocka-Borowicz, M; Rabczynski, M1
Abuşoğlu, G; Akdağ, T; Dursunoğlu, D; Kaynar, M; Saygın, Y; Sivrikaya, A; Ünlü, A1
Asghari, S; Hosseinzadeh-Attar, MJ; Nikooei, P; Norouzy, A; Vasheghani-Farahani, A; Yaseri, M1
Abusoglu, G; Abusoglu, S; Aydemir, HY; Ekmekci, AH; Isık, SMT; Onmaz, DE; Ozturk, S; Sivrikaya, A; Unlu, A1
Adachi, H; Enomoto, M; Fukami, A; Fukumoto, Y; Hamamura, H; Morikawa, N; Nakamura, S; Nohara, Y; Sakaue, A; Toyomasu, K; Yamamoto, M1
Alptekin, H; Karaman, S; Onmaz, DE; Sivrikaya, A1
Abdel Haie, OM; Abed, NT; Almonaem, ERA; Mansour, AI1
Bakker, SJL; Bollenbach, A; Post, A; Tsikas, D1
Alhussini, K; Bening, C; Benitez, RC; Keller, D; Leyh, R; Madrahimov, N; Radakovic, D; Sales, VL1
Dai, Y; Mao, H; Ye, J; Zhang, J; Zheng, W1
Charkiewicz, AE; Garley, M; Jabłońska, E; Maślach, D; Nowak, K; Omeljaniuk, WJ; Ratajczak-Wrona, W1
Chen, Y; Huang, Q; Qin, Z; Tang, L; Tang, X; Zhong, W1
Chan, JYH; Chang-Chien, GP; Hou, CY; Hsu, CN; Lee, CT; Lin, S; Tain, YL1
Couderc, F; Koval, D; Sommerová, B; Tůma, P1
Braun, D; Haen, E; Schlossmann, J1
Miyata, K; Obayashi, K; Ogata, N; Saeki, K; Yoshikawa, T1
He, YL; Li, XM; Nie, F; Xiong, Y; Zhou, XK1
Balfanz, P; Böger, R; Dahl, E; Dreher, M; Hannemann, J; Hartmann, B; Marx, N; Müller-Wieland, D; Schwedhelm, E; Ule, J1
Asıl, M; Kebapçılar, L; Korkmaz, H; Öztürk, B; Temel, T1
Do-Nguyen, CC; Mulinari, L; Ochoa Gautier, JB; Stevens, RM; Throckmorton, A1
Baş, T; Hançer, H; Işık, O; Koç, M; Kutsal, A1
Değertekin, MM; Gezer Taş, S; Güleç, S; İşbir, T; Mutlu, B; Olgun Yıldızeli, Ş; Özveren, O; Şimşek, MA; Türer Cabbar, A; Yanartaş, M; Yıldızeli, B1
Gorbunov, AS; Krylatov, AV; Kurbatov, BK; Logvinov, SV; Maslov, LN; Mukhomedzyanov, AV; Nagarajan, RP; Naryzhnaya, NV; Oeltgen, PR; Prokudina, ES; Saushkin, VV; Sementsov, AS; Voronkov, NS; Zavadovsky, KV1
Dai, Z; Fan, Y; Xiang, S; Zhang, H1
Abusoglu, G; Abusoglu, S; Gezer, İA; Isik, K; Onmaz, DE; Sivrikaya, A; Unlu, A; Yerlikaya, FH1
Chang, KA; Chen, YC; Hsu, MH; Huang, LT; Lin, IC; Sheen, JM1
Akduman, H; Ataş, N; Aydoğan, S; Dilli, D; Kabataş, EU; Oğuz, B; Şah Ipek, M; Zenciroğlu, A1
Choi, S; Islam, SMT; Khan, M; Kim, J; Saxena, N; Singh, AK; Singh, I; Won, J1
Gradek, J; Kusmierczyk, J; Szygula, Z; Szymura, J; Wiecek, M1
Baião, DDS; da Silva, DVT; Paschoalin, VMF; Trindade, LR1
Doroszko, A; Fortuna, P; Gajecki, D; Gawryś, J; Szahidewicz-Krupska, E; Wiśniewski, J1
Attia, JR; Hancock, SJ; Holliday, E; Mangoni, AA; McEvoy, MA; Oldmeadow, C; Peel, R; Smith, WT; Talley, NJ; Walker, MM1
Chen, CH; Guo, BC; Hsu, CP; Lee, TS; Lu, TM1
Aljesri, K; Kavala, AA; Norel, X; Ozen, G; Topal, G; Turkyilmaz, G; Turkyilmaz, S1
Atzler, D; Böger, RH; Duncan, MS; Hannemann, J; Maas, R; Moser, C; Schwedhelm, E; Vasan, RS; Xanthakis, V; Yola, IM1
Aoyagi, H; Ariyoshi, M; Hanada, N; Imamura, A; Kawahara, H; Kosaka, M; Matin, K; Mizukaki, T; Murata, T; Okada, A; Otsuka, R; Sato, T; Suzuki, M; Tateno, K; Uematsu, H; Wakiyama, R; Yamashita, M1
Alpoim, PN; Carvalho, MDG; da Silva, AJ; de Oliveira, MM; Dusse, LMS; Ferreira, LGR; Martins, SR; Mendes, FS; Pinheiro, MB; Rios, DRA; Toledo, SLO1
Al-Dhabi, NA; Arasu, MV; Arockiaraj, J; C, M; Chatterjee, S; Choi, KC; Karuppiah, K; Natarajan, S; Raj, V; Ramanujam, GM; Ramasamy, M1
Chen, MF; Cheng, JF; Li, YJ; Ni, GH; Xie, QY; Yang, TL1
Baser, O; Can, B; Catak, M; Cetin, Z; Guler, S; Kosem, A1
Guo, M; Jiang, GT; Liu, H; Liu, J; She, J; Zhou, B1
Bosch, A; Fromm, MF; Gemeinhardt, A; Gessner, A; Kannenkeril, D; Maas, R; Mayr, A; Schmieder, RE; Staerk, C1
Chen, J; Fan, S; Fang, X; Hou, L; Jie, Z; Li, X; Ma, Q; Ning, L; Qin, A; Shen, S; Wang, H; Wang, J; Wang, S; Wu, Y; Xie, Z; Xu, W; Yuan, P; Zhang, X; Zhao, X1
Mangoni, AA; Zinellu, A1
Aguirre, C; Atsuta, N; Baba, K; Hotta, Y; Ikenaka, K; Ito, D; Kakuda, K; Katsuno, M; Kimura, K; Kimura, Y; Maeda, Y; Mochizuki, H; Nagano, S; Sobue, G; Tatebe, H; Tokuda, T; Torii, R; Yamada, S1
Ding, JJ; Gu, M; Lu, Q; Zhang, WT1
Beckmann, B; Brinkmann, F; Dillenhöfer, S; Frank, M; Hamelmann, E; Hanusch, B; Holtmann, M; Jöckel, KH; Koerner-Rettberg, C; Langrock, C; Legenbauer, T; Lücke, T; Maasjosthusmann, P; Reinehr, T; Sinningen, K; Tsikas, D1
Basile, D; Lee, Y; Singh, J; Steinbach, SML1
Dehnad, A; Hajahmadi, M; Hosseini, S; Janani, L; Mofid, V; Naderi, N; Pourrajab, B; Shidfar, F; Sohouli, MH1
Bonnitcha, P; Fitzpatrick, M; Ireland, A; Koay, YC; Nguyen, VL; O'Sullivan, J; Sullivan, D1
Bode-Böger, SM; Bornstein, SR; Burdin, D; Chen, Y; Cordasic, N; Hilgers, K; Hofmann, A; Hohenstein, B; Hugo, CPM; Jacobi, J; Jarzebska, N; Kolouschek, A; Maas, R; Markov, AG; Martens-Lobenhoffer, J; Morawietz, H; O'Sullivan, JF; Pfluecke, C; Rodionov, RN; Rubets, E; Todorov, V; Weiss, N1
Abd El Hady, NMS; Abdallah, HM; Abdelmageed, SM; Aboelghar, HM; Garib, MI; Mahmoud, AA1
Chen, F; Chen, S; Cui, M; Dong, Q; Fang, K; Wang, Y1
Kellum, JA; Lee, Y; Singh, J1
Gao, H; Li, T; Liu, R; Wang, H; Yin, C; Zhang, Q; Zhang, T1
Belizna, C; Djokovic, A; Dopsaj, V; Marisavljevic, D; Markovic, O; Saponjski, D; Saponjski, J; Stanisavljevic, N; Stojanovich, L; Todic, B; Zdravkovic, M1
Antosiewicz, J; Calder, PC; Chroboczek, M; Fisk, HL; Jost, Z; Przewłócka, K; Tomczyk, M1
Andraweera, PH; Arstall, MA; Kosmider, L; Lassi, ZS; Tiong, P1
Lazaros, G; Oikonomou, E; Papageorgiou, N; Sagris, M; Theofilis, P; Tousoulis, D1
Dimitroulas, T; Doumas, M; Garyfallos, A; Karagiannis, A; Katsiki, N; Kitas, G; Loutradis, C; Malliari, A; Pagkopoulou, E; Soulaidopoulos, S1
Dzięgiel, P; Malicka, I; Martynowicz, H; Podhorska-Okołów, M; Szuba, A; Woźniewski, M1
Doğan, Ö; Haşimi, A; Serdar, CC; Serdar, MA1
Chen, J; Fan, S; Hong, Z; Jie, Z; Ma, Y; Mei, Z; Ni, W; Qin, A; Shen, P; Shen, S; Sun, X; Wan, S; Wang, K; Wang, Q; Wu, H; Wu, Y; Xie, Z; Xu, W; Zhang, H; Zhou, H1
Drapała, A; Samborowska, E; Szlęzak, D; Ufnal, M; Wróbel, M1
Erdogan, H; Gonulveren, G; Gultekin, G; Gultekin, M; Pasa, S; Ural, K1
Fukuo, K; Imamura, T; Otaki, N; Tanino, N; Yano, M; Yokoro, M1
Alghamdi, F; Dowsett, L; Duluc, L; Fast, W; Higgins, E; Leiper, J; Salt, IP1
He, S; Huang, C; Jiang, J; Li, G; Li, N; Li, T; Niu, B; Tong, W; Wang, S; Wu, M; Wu, T; Yan, L1
Anderson, AH; Bhat, Z; Brown, J; Brunengraber, H; Charleston, J; Chen, J; Feldman, HI; He, J; Hostetter, TH; Hsu, CY; Ix, JH; Kimmel, PL; Mehta, R; Rao, P; Sapa, H; Schelling, JR; Schrauben, SJ; Seegmiller, JC; Shafi, T; Shlipak, MG; Townsend, R; Vasan, RS; Xie, D; Zhang, X1
Bełtowski, J; Czechowska, G; Fornal, E; Góralczyk, A; Korolczuk, A; Kozub, A; Marzec-Kotarska, B; Nikolaichuk, H; Pradiuch, A; Stachniuk, A; Trzpil, A; Wójcicka, G1
Bassi, F; Böger, R; Cescutti, D; Cifù, A; Curcio, F; Fabris, M; Fapranzi, S; Hannemann, J; Ripoli, A; Sbrana, F; Sozio, E; Sponza, M; Tascini, C; Vetrugno, L1
Antosiewicz, J; Brzezińska, P; Kochanowicz, A; Kowalik, T; Mieszkowski, J; Niespodziński, B; Reczkowicz, J; Stankiewicz, B; Waldziński, T; Zolodkiewicz, K1

Reviews

236 review(s) available for n,n-dimethylarginine and arginine

ArticleYear
[Endothelial dysfunction in peripheral arterial occlusive disease: from basic research to clinical use].
    VASA. Zeitschrift fur Gefasskrankheiten, 1997, Volume: 26, Issue:3

    Topics: Arginine; Arterial Occlusive Diseases; Arteriosclerosis; Endothelium, Vascular; Humans; Nitric Oxide; Vasodilation

1997
Biological significance of endogenous methylarginines that inhibit nitric oxide synthases.
    Cardiovascular research, 1999, Aug-15, Volume: 43, Issue:3

    Topics: Amidohydrolases; Animals; Arginine; Cytosol; Enzyme Inhibitors; Humans; Hydrolases; Isoenzymes; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Protein-Arginine N-Methyltransferases

1999
Relationship of asymmetric dimethylarginine to dialysis treatment and atherosclerotic disease.
    Kidney international. Supplement, 2001, Volume: 78

    Topics: Arginine; Arteriosclerosis; Biomarkers; Humans; In Vitro Techniques; Kidney Failure, Chronic; Nitric Oxide; Peritoneal Dialysis; Renal Dialysis; Uremia

2001
Atherogenesis and the arginine hypothesis.
    Current atherosclerosis reports, 2001, Volume: 3, Issue:3

    Topics: Arginine; Enzyme Inhibitors; Humans; Nitric Oxide

2001
ADMA (asymmetric dimethylarginine): an atherosclerotic disease mediating agent in patients with renal disease?
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2001, Volume: 16, Issue:9

    Topics: Animals; Arginine; Arteriosclerosis; Enzyme Inhibitors; Humans; Kidney Diseases; Nitric Oxide Synthase

2001
Nitric oxide synthase and hypertension.
    Current opinion in nephrology and hypertension, 2002, Volume: 11, Issue:2

    Topics: Animals; Arginine; Endothelium, Vascular; Humans; Hypertension; Nitric Oxide Synthase

2002
[Biological and pathophysiological roles of endogenous methylarginines as inhibitors of nitric oxide synthase].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2002, Volume: 119, Issue:1

    Topics: Animals; Arginine; Nitric Oxide Synthase; omega-N-Methylarginine

2002
Mechanisms of dysfunction of the nitric oxide pathway in vascular diseases.
    Nitric oxide : biology and chemistry, 2002, Volume: 6, Issue:2

    Topics: Animals; Arginine; Endothelium, Vascular; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Polymorphism, Genetic; Signal Transduction; Vascular Diseases

2002
Asymmetric dimethylarginine (ADMA): a potential link between endothelial dysfunction and cardiovascular diseases in insulin resistance syndrome?
    Diabetologia, 2002, Volume: 45, Issue:12

    Topics: Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Metabolic Syndrome

2002
Cardiac allograft vasculopathy and dysregulation of the NO synthase pathway.
    Arteriosclerosis, thrombosis, and vascular biology, 2003, Apr-01, Volume: 23, Issue:4

    Topics: Animals; Arginine; Cardiovascular Agents; Coronary Artery Disease; Endothelium, Vascular; Graft Rejection; Heart Transplantation; Humans; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Postoperative Complications; Rabbits; Transplantation, Homologous; Vasodilation; Vasomotor System

2003
[Cardiovascular events in chronic advanced renal insufficiency. Current concepts].
    Recenti progressi in medicina, 2003, Volume: 94, Issue:3

    Topics: Anemia; Arginine; C-Reactive Protein; Cardiovascular Diseases; Humans; Hyperhomocysteinemia; Hyperlipidemias; Hypertension; Inflammation; Kidney Failure, Chronic; Nitric Oxide Synthase; Risk Factors; Sleep Apnea Syndromes; Smoking

2003
Asymmetric dimethylarginine: a cardiovascular risk factor in renal disease?
    Kidney international. Supplement, 2003, Issue:84

    Topics: Arginine; Cardiovascular Diseases; Humans; Kidney Diseases; Risk Factors

2003
Potential mechanisms of impaired endothelial function in arterial hypertension and hypercholesterolemia.
    Current hypertension reports, 2003, Volume: 5, Issue:3

    Topics: Animals; Arginine; Biological Availability; Cyclic GMP; Endothelium, Vascular; Humans; Hypercholesterolemia; Hypertension; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Prognosis; Vasodilation

2003
[Atherosclerosis and uremia: signifance of non-traditional risk factors].
    Wiener klinische Wochenschrift, 2003, Apr-30, Volume: 115, Issue:7-8

    Topics: Arginine; Arteriosclerosis; Homocysteine; Humans; Kidney Failure, Chronic; Oxidative Stress; Phosphates; Prognosis; Risk Factors; Uremia

2003
Functional changes in the ageing kidney: is there a role for asymmetric dimethylarginine?
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2003, Volume: 18, Issue:7

    Topics: Adult; Aged; Aging; Arginine; Enzyme Inhibitors; Humans; Kidney; Kidney Diseases

2003
[ADMA (asymmetric dimethyl arginine) and coronary artery disease].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 5

    Topics: Animals; Arginine; Coronary Disease; Humans

2003
Serum concentrations of asymmetric (ADMA) and symmetric (SDMA) dimethylarginine in patients with chronic kidney diseases.
    Clinica chimica acta; international journal of clinical chemistry, 2003, Volume: 336, Issue:1-2

    Topics: Amino Acids; Arginine; Case-Control Studies; Creatinine; Heart Diseases; Humans; Hypertension; Kidney Failure, Chronic; Kidney Transplantation; Regression Analysis; Renal Dialysis

2003
A novel mechanism for pulmonary arterial hypertension?
    Circulation, 2003, Sep-23, Volume: 108, Issue:12

    Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Humans; Hypertension, Pulmonary; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pulmonary Artery; Rats; Vasomotor System

2003
The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor.
    Cardiovascular research, 2003, Oct-01, Volume: 59, Issue:4

    Topics: Amidohydrolases; Arginine; Biomarkers; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide Synthase; Risk Factors

2003
ADMA: a novel risk factor that explains excess cardiovascular event rate in patients with end-stage renal disease.
    Atherosclerosis. Supplements, 2003, Volume: 4, Issue:4

    Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Kidney Failure, Chronic; Nitric Oxide Synthase; Risk Factors

2003
Plasma concentration of asymmetric dimethylarginine and the risk of coronary heart disease: rationale and design of the multicenter CARDIAC study.
    Atherosclerosis. Supplements, 2003, Volume: 4, Issue:4

    Topics: Arginine; Coronary Disease; Endothelium, Vascular; Enzyme Inhibitors; Follow-Up Studies; Humans; Nitric Oxide; Prospective Studies; Risk Factors; Vasodilation

2003
The DDAH/ADMA/NOS pathway.
    Atherosclerosis. Supplements, 2003, Volume: 4, Issue:4

    Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide Synthase; Vasodilation

2003
ADMA and oxidative stress.
    Atherosclerosis. Supplements, 2003, Volume: 4, Issue:4

    Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide Synthase; Oxidative Stress; Vasodilation

2003
NO and angiogenesis.
    Atherosclerosis. Supplements, 2003, Volume: 4, Issue:4

    Topics: Angiogenesis Inhibitors; Arginine; Cardiovascular Diseases; Cell Movement; Cell Survival; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide

2003
Hyperhomocysteinemia, endothelial dysfunction, and cardiovascular risk: the potential role of ADMA.
    Atherosclerosis. Supplements, 2003, Volume: 4, Issue:4

    Topics: Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hyperhomocysteinemia; Risk Factors

2003
Novel cardiovascular risk factors in end-stage renal disease.
    Journal of the American Society of Nephrology : JASN, 2004, Volume: 15 Suppl 1

    Topics: Arginine; Calcinosis; Cardiovascular Diseases; Humans; Hypertension; Inflammation; Kidney Failure, Chronic; Nitric Oxide Synthase; Oxidative Stress; Risk Factors

2004
Atherosclerosis in dialyzed patients.
    Blood purification, 2004, Volume: 22, Issue:1

    Topics: Anemia; Animals; Arginine; Arteriosclerosis; Biomarkers; Cause of Death; Comorbidity; Coronary Artery Disease; Diabetes Mellitus; Europe; Humans; Hyperlipidemias; Hypertension; Inflammation; Kidney Failure, Chronic; Mice; Mice, Knockout; Nitric Oxide; Phosphates; Renal Dialysis

2004
Asymmetric dimethylarginine (ADMA) modulates endothelial function--therapeutic implications.
    Vascular medicine (London, England), 2003, Volume: 8, Issue:3

    Topics: Animals; Arginine; Cardiovascular Diseases; Drug Therapy, Combination; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide Synthase; Up-Regulation

2003
[Asymmetrical methylarginine (ADMA) as a cardiovascular risk factor: epidemiological and prospective data].
    Deutsche medizinische Wochenschrift (1946), 2004, Apr-08, Volume: 129, Issue:15

    Topics: Adult; Aged; Aged, 80 and over; Animals; Arginine; Arteriosclerosis; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Cells, Cultured; Child; Coronary Disease; Diabetes Mellitus, Type 2; Disease Models, Animal; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Female; Free Radicals; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Multicenter Studies as Topic; Multivariate Analysis; Nitric Oxide Synthase; Oxidative Stress; Pre-Eclampsia; Pregnancy; Prospective Studies; Rabbits; Regression Analysis; Renal Dialysis; Risk Factors; Stroke

2004
Asymmetrical dimethylarginine: the Uber marker?
    Circulation, 2004, Apr-20, Volume: 109, Issue:15

    Topics: Amidohydrolases; Arginine; Arteriosclerosis; Biomarkers; Blood Vessels; Endothelium, Vascular; Humans; Nitric Oxide Synthase; Risk Factors; Vascular Resistance

2004
Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway.
    Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Cardiovascular Physiological Phenomena; Diabetes Mellitus; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Mice; Models, Biological; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Pre-Eclampsia; Pregnancy; Protein-Arginine N-Methyltransferases; Renal Insufficiency

2004
[Involvement of homocysteine in the pathogenesis of hypertension and hypertensive target-organ damage].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 3

    Topics: Arginine; Arteriosclerosis; Biopterins; Cell Division; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Hypertension; Insulin Resistance; Muscle, Smooth, Vascular; Nitric Oxide; Oxidative Stress; Risk Factors

2004
[NO and hypertension].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 3

    Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Arginine; Arteriosclerosis; Biopterins; C-Reactive Protein; Endothelium, Vascular; Humans; Hypertension; Mutation; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Perindopril; Reactive Oxygen Species; Vasodilation

2004
The pivotal role of nitric oxide for vascular health.
    The Canadian journal of cardiology, 2004, Volume: 20 Suppl B

    Topics: Arginine; Arteriosclerosis; Cardiovascular Diseases; Disease Progression; Endothelium, Vascular; Female; Homeostasis; Humans; Male; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Predictive Value of Tests; Risk Factors; Sensitivity and Specificity; Survival Analysis

2004
Asymmetric dimethylarginine (ADMA) and acute vascular events.
    Clinica chimica acta; international journal of clinical chemistry, 2004, Volume: 348, Issue:1-2

    Topics: Acute Disease; Angina Pectoris; Arginine; Cardiovascular Diseases; Humans; Myocardial Infarction; Stroke

2004
Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the "L-arginine paradox" and acts as a novel cardiovascular risk factor.
    The Journal of nutrition, 2004, Volume: 134, Issue:10 Suppl

    Topics: Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide Synthase; Risk Factors

2004
Elimination of asymmetric dimethylarginine by the kidney and the liver: a link to the development of multiple organ failure?
    The Journal of nutrition, 2004, Volume: 134, Issue:10 Suppl

    Topics: Animals; Arginine; Enzyme Inhibitors; Humans; Kidney; Liver; Multiple Organ Failure; Nitric Oxide Synthase

2004
[Asymmetric dimethylarginine and endothelial dysfunction].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 9

    Topics: Amidohydrolases; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Hemodynamics; Humans; Methylation; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Renin-Angiotensin System

2004
Asymmetric dimethyl-L-arginine (ADMA): a possible link between homocyst(e)ine and endothelial dysfunction.
    Current drug metabolism, 2005, Volume: 6, Issue:1

    Topics: Animals; Arginine; Arteriosclerosis; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Nitric Oxide; Vascular Diseases

2005
L-Arginine improves vascular function by overcoming deleterious effects of ADMA, a novel cardiovascular risk factor.
    Alternative medicine review : a journal of clinical therapeutic, 2005, Volume: 10, Issue:1

    Topics: Arginine; Arteriosclerosis; Cardiovascular Diseases; Endothelium, Vascular; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III

2005
Endothelial cell dysfunction: the syndrome in making.
    Kidney international, 2005, Volume: 67, Issue:5

    Topics: Animals; Apoptosis; Arginine; Cardiovascular Diseases; Cellular Senescence; Endothelium, Vascular; Glycation End Products, Advanced; Humans; Hyperhomocysteinemia; Kidney Diseases; Models, Biological; Oxidative Stress; Syndrome

2005
Cardiovascular tests: use & limits of biochemical markers - therapeutic measurements of ADMA involved in cardiovascular disorders.
    Current pharmaceutical design, 2005, Volume: 11, Issue:17

    Topics: Arginine; Biomarkers; Diagnostic Techniques, Cardiovascular; Humans

2005
Clinical epidemiology of major nontraditional risk factors in peritoneal dialysis patients.
    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 2005, Volume: 25 Suppl 3

    Topics: Arginine; Autonomic Nervous System Diseases; C-Reactive Protein; Cardiovascular Diseases; Humans; Hyperhomocysteinemia; Inflammation; Italy; Kidney Failure, Chronic; Nitric Oxide Synthase; Norepinephrine; Peritoneal Dialysis; Risk Factors

2005
Asymmetric dimethylarginine: a cardiovascular risk factor and a uremic toxin coming of age?
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 46, Issue:2

    Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Cardiovascular Diseases; Carotid Arteries; Carotid Stenosis; Cross-Sectional Studies; Endocrine System Diseases; Endothelium, Vascular; Haplorhini; Humans; Hypertension; Kidney Diseases; Kidney Failure, Chronic; Nitric Oxide; Rats; Rats, Inbred Dahl; Renal Dialysis; Risk Factors; Sodium Chloride, Dietary; Tunica Intima; Tunica Media; Uremia

2005
Elevated levels of asymmetric dimethylarginine (ADMA) as a marker of cardiovascular disease and mortality.
    Clinical chemistry and laboratory medicine, 2005, Volume: 43, Issue:10

    Topics: Animals; Arginine; Biomarkers; Cardiovascular Diseases; Endothelial Cells; Humans; Nitric Oxide; Prognosis

2005
Measurement of asymmetric dimethylarginine in plasma: methodological considerations and clinical relevance.
    Clinical chemistry and laboratory medicine, 2005, Volume: 43, Issue:10

    Topics: Animals; Arginine; Cardiovascular Diseases; Homocysteine; Humans; Risk Factors; Sensitivity and Specificity

2005
Biomarkers in chronic kidney disease: utility and issues towards better understanding.
    Current opinion in nephrology and hypertension, 2005, Volume: 14, Issue:6

    Topics: Animals; Arginine; Biomarkers; C-Reactive Protein; Chronic Disease; Disease Progression; Glomerular Filtration Rate; Homocysteine; Humans; Kidney Diseases; Kidney Failure, Chronic; Natriuretic Peptide, Brain; Troponin T

2005
Nitric oxide pathway as new drug targets for refractory hypertension.
    Current pharmaceutical design, 2005, Volume: 11, Issue:25

    Topics: Animals; Antihypertensive Agents; Arginine; Blood Pressure; Endothelium, Vascular; Humans; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Signal Transduction; Superoxides

2005
Endothelial function and its assessment.
    Expert opinion on investigational drugs, 2005, Volume: 14, Issue:11

    Topics: Animals; Arginine; Atherosclerosis; C-Reactive Protein; Endothelial Cells; Endothelin-1; Endothelium, Vascular; Humans; Nitric Oxide; Stem Cells; Tissue Plasminogen Activator; Vascular Cell Adhesion Molecule-1; Vasodilation; von Willebrand Factor

2005
[Molecular mechanisms of dysfunction of vascular endothelium].
    Kardiologiia, 2005, Volume: 45, Issue:12

    Topics: Adult; Animals; Apoptosis; Arginine; Atherosclerosis; Cardiovascular Diseases; Cells, Cultured; Child; Endothelial Cells; Endothelin-1; Endothelium, Vascular; Epoprostenol; Female; GTP-Binding Proteins; Hemodynamics; Humans; Macrophages; Male; Multienzyme Complexes; Mutation; NADH, NADPH Oxidoreductases; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Pregnancy; Rats; Rats, Inbred Dahl; Reactive Oxygen Species; Risk Factors; RNA, Messenger

2005
Endogenous production of nitric oxide synthase inhibitors.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Arginine; Enzyme Inhibitors; Humans; Isoenzymes; Nitric Oxide Synthase; omega-N-Methylarginine; Protein-Arginine N-Methyltransferases; Renal Insufficiency

2005
ADMA: its role in vascular disease.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Mice; Mice, Transgenic; Models, Animal; Nitric Oxide; Nitric Oxide Synthase; Risk Factors

2005
Asymmetric dimethylarginine (ADMA) and cardiovascular disease: insights from prospective clinical trials.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Clinical Trials as Topic; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide; Nitric Oxide Synthase; Prospective Studies; Randomized Controlled Trials as Topic; Risk Factors; Vasodilation

2005
ADMA and hyperhomocysteinemia.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Homocysteine; Humans; Hyperhomocysteinemia; Nitric Oxide; Nitric Oxide Synthase Type III; Risk Factors; Superoxides; Vasodilation

2005
Insulin resistance: potential role of the endogenous nitric oxide synthase inhibitor ADMA.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Animals; Arginine; Cardiovascular Diseases; Drug Evaluation, Preclinical; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metabolic Syndrome; Nitric Oxide; Nitric Oxide Synthase; Randomized Controlled Trials as Topic; Risk Factors; Vasodilation

2005
DDAH gene and cardiovascular risk.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Amidohydrolases; Arginine; Cardiovascular Diseases; Humans; Hypertension; Male; Mutation; Polymorphism, Genetic; Risk Factors

2005
Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA).
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Amidohydrolases; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Biomarkers; Cardiovascular Diseases; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperhomocysteinemia; Nitric Oxide; Nitric Oxide Synthase; Protein-Arginine N-Methyltransferases; Renal Insufficiency

2005
Spotlight on endothelial progenitor cell inhibitors: short review.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Angiotensin II; Animals; Arginine; Atherosclerosis; Bone Marrow Cells; Cell Differentiation; Cell Movement; Endothelial Cells; Humans; Lipoproteins, LDL; Nitric Oxide; Stem Cells

2005
ADMA metabolism and clearance.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Amidohydrolases; Amino Acid Transport Systems, Basic; Animals; Arginine; Humans; Kidney; Kinetics; Liver; Methylation; Peptide Hydrolases; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Proteins

2005
Quantification of ADMA: analytical approaches.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Arginine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Enzyme-Linked Immunosorbent Assay; Gas Chromatography-Mass Spectrometry; Humans; omega-N-Methylarginine; Reproducibility of Results

2005
[The best of epidemiology and cardiovascular prevention in 2005].
    Archives des maladies du coeur et des vaisseaux, 2006, Volume: 99 Spec No 1, Issue:1

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Diabetes Complications; Environmental Pollutants; Humans; Metabolic Syndrome; Publishing; Risk Factors; Smoking

2006
[Nephrosclerosis: Pathogenesis, pathophysiology, and therapy].
    Nihon rinsho. Japanese journal of clinical medicine, 2006, Volume: 64 Suppl 2

    Topics: Animals; Arginine; Atherosclerosis; Embolism, Cholesterol; Endothelium, Vascular; Free Radicals; Homocysteine; Humans; Hypertension, Renal; Nephrosclerosis; Renal Artery Obstruction

2006
Asymmetric dimethylarginine (ADMA): a cardiovascular and renal risk factor on the move.
    Journal of hypertension, 2006, Volume: 24, Issue:4

    Topics: Arginine; Cardiovascular Diseases; Humans; Renal Insufficiency; Risk Factors

2006
[Asymmetric dimethylarginine--a novel cardiovascular risk factor].
    Vnitrni lekarstvi, 2006, Volume: 52, Issue:3

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus; Endothelium, Vascular; Humans; Kidney Failure, Chronic; Nitric Oxide; Nitric Oxide Synthase; Vasodilation

2006
[The importance of regulation of endogenous methylarginine concentrations in clinical practice].
    Przeglad lekarski, 2005, Volume: 62, Issue:12

    Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Humans; Protein-Arginine N-Methyltransferases

2005
L-arginine: a new opportunity in the management of clinical derangements in dialysis patients.
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2006, Volume: 16, Issue:3

    Topics: Adult; Aged; Animals; Arginine; Citrulline; Diabetic Nephropathies; Endothelium, Vascular; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Renal Dialysis

2006
[Nitric oxide].
    Nihon rinsho. Japanese journal of clinical medicine, 2006, Volume: 64 Suppl 5

    Topics: Adiponectin; Aldosterone; Animals; Arginine; Blood Pressure; Cardiovascular Diseases; Endothelium, Vascular; Humans; Hypertension; Nitric Oxide; Nitric Oxide Synthase Type III; Stem Cells; Stress, Mechanical

2006
HPLC analysis of ADMA and other methylated L-arginine analogs in biological fluids.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, May-15, Volume: 851, Issue:1-2

    Topics: Animals; Arginine; Body Fluids; Chromatography, High Pressure Liquid; Humans; Methylation; Reference Values; Reproducibility of Results

2007
Arginine, arginine analogs and nitric oxide production in chronic kidney disease.
    Nature clinical practice. Nephrology, 2006, Volume: 2, Issue:4

    Topics: Absorption; Amidohydrolases; Arginine; Biological Availability; Cardiovascular Diseases; Chronic Disease; Comorbidity; Enzyme Inhibitors; Humans; Kidney; Kidney Diseases; Kidney Failure, Chronic; Nitric Oxide; Nitric Oxide Synthase; Polymorphism, Genetic

2006
Endogenous inhibitors of nitric oxide and preeclampsia: a review.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2006, Volume: 19, Issue:8

    Topics: Amidohydrolases; Arginine; Endothelium, Vascular; Female; Humans; Nitric Oxide; Nitric Oxide Synthase; Placental Circulation; Pre-Eclampsia; Pregnancy; Uterus; Vasodilation

2006
The lung in the balance: arginine, methylated arginines, and nitric oxide.
    American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 292, Issue:1

    Topics: Animals; Arginine; Humans; Lung; Methylation; Models, Biological; Nitric Oxide; omega-N-Methylarginine; Protein-Arginine N-Methyltransferases

2007
Protein arginine methylation: Cellular functions and methods of analysis.
    Biochimica et biophysica acta, 2006, Volume: 1764, Issue:12

    Topics: Arginine; DNA Repair; F-Box Proteins; Humans; Mass Spectrometry; Methyltransferases; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Proteomics; RNA Processing, Post-Transcriptional; S-Adenosylmethionine; Signal Transduction; Transcription, Genetic

2006
An overview of plasma concentrations of asymmetric dimethylarginine (ADMA) in health and disease and in clinical studies: methodological considerations.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, May-15, Volume: 851, Issue:1-2

    Topics: Animals; Arginine; Chromatography, High Pressure Liquid; Clinical Laboratory Techniques; Disease; Health; Humans; Mass Spectrometry

2007
Asymmetric dimethylarginine in end-stage renal disease patients: a biomarker modifiable by calcium blockade and angiotensin II antagonism?
    Kidney international, 2006, Volume: 70, Issue:12

    Topics: Amlodipine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Arginine; Biomarkers; Calcium; Calcium Channel Blockers; Humans; Kidney Failure, Chronic; Risk Factors; Tetrazoles; Valine; Valsartan

2006
Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH.
    Neurological research, 2006, Volume: 28, Issue:7

    Topics: Amidohydrolases; Animals; Arginine; Cerebral Arteries; Cerebrovascular Circulation; Humans; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2006
Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: assessing the health of the endothelium.
    Vascular health and risk management, 2005, Volume: 1, Issue:1

    Topics: Arginine; Biological Factors; Biomarkers; C-Reactive Protein; Cell Differentiation; Cell Proliferation; Cellular Senescence; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelial Cells; Endothelium, Vascular; Humans; Hyperglycemia; Nitric Oxide; Oxidative Stress; Stem Cells; Vasodilation; Vasodilator Agents

2005
Asymmetric dimethylarginine (ADMA) a novel cardiovascular risk factor--evidence from epidemiological and prospective clinical trials.
    Pharmacological reports : PR, 2006, Volume: 58 Suppl

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Clinical Trials as Topic; Cross-Sectional Studies; Endothelium, Vascular; Humans; Nitric Oxide; Nitric Oxide Synthase; Prospective Studies; Risk Factors

2006
[Coronary allograft vasculopathy: pathophysiological interaction between the immune system, infections and metabolic syndrome].
    Giornale italiano di cardiologia (2006), 2007, Volume: 8, Issue:2

    Topics: Animals; Arginine; Clinical Trials as Topic; Coronary Disease; Cytomegalovirus Infections; Disease Models, Animal; Endothelium, Vascular; Graft Rejection; Graft Survival; Heart Transplantation; Humans; Hypolipidemic Agents; Immunosuppression Therapy; Immunosuppressive Agents; Metabolic Syndrome; Quality of Life; Risk Assessment; Risk Factors; Rodentia; Stents; Time Factors

2007
The past, presence and future of ADMA in nephrology.
    Nephrologie & therapeutique, 2007, Volume: 3, Issue:2

    Topics: Arginine; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Kidney Diseases; Kidney Function Tests; Nitric Oxide Synthase; Risk Factors

2007
Asymmetric dimethylarginine (ADMA) in vascular, renal and hepatic disease and the regulatory role of L-arginine on its metabolism.
    Molecular genetics and metabolism, 2007, Volume: 91, Issue:4

    Topics: Arginine; Citrulline; Dietary Supplements; Hepatocytes; Homocysteine; Humans; Kidney Diseases; Liver Diseases; Nitric Oxide Synthase; Obesity; Risk Factors; Vascular Diseases

2007
C-reactive protein and asymmetric dimethylarginine: markers or mediators in cardiovascular disorders?
    Current pharmaceutical design, 2007, Volume: 13, Issue:16

    Topics: Animals; Arginine; Atherosclerosis; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Humans; Inflammation; Nitric Oxide; Risk Assessment; Risk Factors

2007
Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease.
    Clinical and experimental nephrology, 2007, Volume: 11, Issue:2

    Topics: Arginine; Cardiovascular Diseases; Chronic Disease; Endothelium, Vascular; Humans; Kidney Diseases; Nitric Oxide; Nitric Oxide Synthase

2007
Chronic kidney disease: effects on the cardiovascular system.
    Circulation, 2007, Jul-03, Volume: 116, Issue:1

    Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Atherosclerosis; Biomarkers; Bone Resorption; Calcinosis; Calcium; Cardiovascular Diseases; Chronic Disease; Clinical Trials as Topic; Cohort Studies; Creatinine; Cystatin C; Cystatins; Diabetes Complications; Disease Progression; Dogs; Dyslipidemias; Endothelium, Vascular; Glomerular Filtration Rate; Humans; Hypertension, Renal; Inflammation Mediators; Kidney Diseases; Oxidative Stress; Phosphates; Renin-Angiotensin System; Risk Factors

2007
Asymmetric dimethylarginine (ADMA)--a modulator of nociception in opiate tolerance and addiction?
    Nitric oxide : biology and chemistry, 2007, Volume: 17, Issue:2

    Topics: Analgesics, Opioid; Arginine; Drug Tolerance; Humans; Nitric Oxide Synthase Type I; Opioid-Related Disorders; Pain

2007
Arginase: a critical regulator of nitric oxide synthesis and vascular function.
    Clinical and experimental pharmacology & physiology, 2007, Volume: 34, Issue:9

    Topics: Animals; Arginase; Arginine; Cardiovascular Diseases; Cell Proliferation; Collagen; Endothelium, Vascular; Homeostasis; Humans; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Urea

2007
Dimethylarginine dimethylaminohydrolase: a new therapeutic target for the modulation of nitric oxide and angiogenesis.
    Current opinion in investigational drugs (London, England : 2000), 2007, Volume: 8, Issue:9

    Topics: Amidohydrolases; Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Animals; Arginine; Endothelium, Vascular; Humans; Neovascularization, Pathologic; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III

2007
Nitric oxide deficiency in chronic kidney disease.
    American journal of physiology. Renal physiology, 2008, Volume: 294, Issue:1

    Topics: Arginine; Chronic Disease; Humans; Kidney Diseases; Nitric Oxide; Nitric Oxide Synthase

2008
Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Diabetes Mellitus; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Kidney; Kidney Diseases; Liver Diseases; Nitric Oxide; Nitric Oxide Synthase; Vasodilation

2007
Emerging biomarkers for evaluating cardiovascular risk in the chronic kidney disease patient: how do new pieces fit into the uremic puzzle?
    Clinical journal of the American Society of Nephrology : CJASN, 2008, Volume: 3, Issue:2

    Topics: Albuminuria; Arginine; Cardiovascular Diseases; Chronic Disease; Endothelium, Vascular; Humans; Kidney Diseases; Ossification, Heterotopic; Oxidative Stress; Risk Assessment; Uremia

2008
Biomarkers in acute and chronic kidney disease.
    Current opinion in nephrology and hypertension, 2008, Volume: 17, Issue:2

    Topics: Acute Kidney Injury; Acute-Phase Proteins; Arginine; Biomarkers; Cystatin C; Cystatins; Fatty Acid-Binding Proteins; Hepatitis A Virus Cellular Receptor 1; Humans; Interleukin-18; Lipocalin-2; Lipocalins; Membrane Glycoproteins; Predictive Value of Tests; Prognosis; Proto-Oncogene Proteins; Receptors, Virus; Renal Insufficiency, Chronic; Reproducibility of Results; Severity of Illness Index

2008
Asymmetric dimethylarginine--mechanisms and targets for therapeutic management.
    Folia medica, 2008, Volume: 50, Issue:1

    Topics: Angiotensin-Converting Enzyme Inhibitors; Arginine; Endothelium, Vascular; Estrogen Replacement Therapy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypoglycemic Agents; Nitric Oxide Synthase Type III

2008
Determination of asymmetric dimethylarginine in biological fluids: a paradigm for a successful analytical story.
    Current opinion in clinical nutrition and metabolic care, 2008, Volume: 11, Issue:5

    Topics: Arginine; Calibration; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Humans; Mass Spectrometry; Reference Values; Sensitivity and Specificity; Solid Phase Extraction

2008
[Pathophysiology of mild hypertension: role of endothelial function].
    Nihon rinsho. Japanese journal of clinical medicine, 2008, Volume: 66, Issue:8

    Topics: Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arginine; Calcium Channel Blockers; Endothelium, Vascular; Humans; Hypertension; Nitric Oxide; Oxidative Stress; Randomized Controlled Trials as Topic; Severity of Illness Index

2008
Cardiovascular disease in patients with diabetic nephropathy.
    Current molecular medicine, 2008, Volume: 8, Issue:6

    Topics: Anemia; Arginine; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Enzyme Inhibitors; Glycation End Products, Advanced; Homocysteine; Humans; Prognosis; Risk Factors

2008
[Endothelial injury and CKD].
    Nihon rinsho. Japanese journal of clinical medicine, 2008, Volume: 66, Issue:9

    Topics: Animals; Arginine; Cardiovascular Diseases; Chronic Disease; Endothelium, Vascular; Humans; Kidney Diseases; Kidney Failure, Chronic; Nitric Oxide; Risk Factors

2008
Asymmetric dimethylarginine (ADMA) and other endogenous nitric oxide synthase (NOS) inhibitors as an important cause of vascular insulin resistance.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2008, Volume: 40, Issue:9

    Topics: Animals; Arginine; Endothelium; Enzyme Inhibitors; Humans; Insulin Resistance; Nitric Oxide; Nitric Oxide Synthase

2008
[Asymmetric dimethylarginine (ADMA): A cardiovascular risk factor].
    Wiener klinische Wochenschrift, 2008, Volume: 120, Issue:15-16

    Topics: Adult; Arginine; Austria; Biomarkers; Cardiovascular Diseases; Humans; Male; Prevalence; Risk Assessment; Risk Factors

2008
Cardiac biomarkers and chronic renal diseases.
    Bratislavske lekarske listy, 2008, Volume: 109, Issue:8

    Topics: Animals; Arginine; Biomarkers; C-Reactive Protein; Coronary Artery Disease; Disease Progression; Homocysteine; Humans; Kidney Failure, Chronic; Natriuretic Peptide, Brain; Troponin

2008
[Novelties in the field of progression factors in chronic kidney disease].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2008, Volume: 28 Suppl 5

    Topics: Adult; Amidohydrolases; Animals; Arginine; Carbon; Cardiovascular Diseases; Chronic Disease; Clinical Trials as Topic; Disease Progression; Female; Genetic Therapy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infant, Low Birth Weight; Infant, Newborn; Kidney Diseases; Male; Oxides; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Uremia; Uric Acid

2008
L-arginine analogs--inactive markers or active agents in atherogenesis?
    Cardiovascular & hematological agents in medicinal chemistry, 2008, Volume: 6, Issue:4

    Topics: Arginine; Atherosclerosis; Biomarkers; Coronary Disease; Endothelium, Vascular; Humans; Inflammation; Nitric Oxide; Oxidative Stress

2008
Asymmetric dimethylarginine: a novel marker of risk and a potential target for therapy in chronic kidney disease.
    Current opinion in nephrology and hypertension, 2008, Volume: 17, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Chronic Disease; Disease Progression; Genetic Therapy; Glomerular Filtration Rate; Growth Hormone; Humans; Kidney Diseases; Obesity; Risk Factors; Severity of Illness Index; Treatment Outcome

2008
Roles of oxidants, nitric oxide, and asymmetric dimethylarginine in endothelial function.
    Journal of cardiovascular pharmacology and therapeutics, 2008, Volume: 13, Issue:4

    Topics: Animals; Arginine; Atherosclerosis; Endothelium, Vascular; Humans; Models, Biological; Nitric Oxide; Oxidants; Reactive Oxygen Species; Risk Factors

2008
ADMA, cardiovascular disease and diabetes.
    Diabetes research and clinical practice, 2008, Dec-15, Volume: 82 Suppl 2

    Topics: Arginine; Cardiovascular Diseases; Diabetes Mellitus; Humans; Models, Biological

2008
Role of asymmetric dimethylarginine (ADMA) in diabetic vascular complications.
    Current pharmaceutical design, 2008, Volume: 14, Issue:25

    Topics: Amidohydrolases; Animals; Arginine; Diabetic Angiopathies; Humans; Nitric Oxide Synthase; Risk Factors

2008
From arginine methylation to ADMA: a novel mechanism with therapeutic potential in chronic lung diseases.
    BMC pulmonary medicine, 2009, Jan-29, Volume: 9

    Topics: Arginine; Biomarkers; Chronic Disease; Humans; Lung Diseases; Methylation; Protein Processing, Post-Translational

2009
Dimethylarginine dimethylaminohydrolase regulation: a novel therapeutic target in cardiovascular disease.
    Expert opinion on drug metabolism & toxicology, 2009, Volume: 5, Issue:3

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Agents; Cardiovascular Diseases; Disease Progression; Drug Delivery Systems; Gene Expression Regulation, Enzymologic; Humans; Nitric Oxide

2009
Asymmetric dimethylarginine (ADMA): an endogenous inhibitor of nitric oxide synthase and a novel cardiovascular risk molecule.
    Medical science monitor : international medical journal of experimental and clinical research, 2009, Volume: 15, Issue:4

    Topics: Animals; Arginine; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Kidney; Nitric Oxide Synthase; Risk Factors

2009
[Biology of arterial ageing and arteriosclerosis].
    Comptes rendus biologies, 2009, Volume: 332, Issue:5

    Topics: Adult; Aged; Aging; Arginine; Arteriosclerosis; Atherosclerosis; Calcinosis; Diagnostic Techniques, Cardiovascular; Endothelium, Vascular; Extracellular Matrix; Female; Humans; Hypertension; Lipoproteins; Male; Middle Aged; Monocytes; Osteoblasts; Tunica Media; Vascular Resistance

2009
Asymmetric dimethylarginine (ADMA) and endothelial dysfunction: implications for atherogenesis.
    Clinics (Sao Paulo, Brazil), 2009, Volume: 64, Issue:5

    Topics: Animals; Arginine; Atherosclerosis; Biomarkers; Endothelium, Vascular; Humans; Nitric Oxide; Renal Insufficiency, Chronic

2009
Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality--an update on patient populations with a wide range of cardiovascular risk.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Animals; Arginine; Biomarkers; Cardiovascular Diseases; Clinical Trials as Topic; Humans; Prospective Studies; Risk Factors

2009
ADMA and the role of the genes: lessons from genetically modified animals and human gene polymorphisms.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Animals; Animals, Genetically Modified; Arginine; Disease Models, Animal; Humans; Polymorphism, Genetic

2009
Cellular ADMA: regulation and action.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Animals; Arginine; Cardiovascular Diseases; Endothelial Cells; Humans; Nitric Oxide Synthase; Signal Transduction

2009
Role of the PRMT-DDAH-ADMA axis in the regulation of endothelial nitric oxide production.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Cardiovascular Diseases; Endothelium, Vascular; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Protein-Arginine N-Methyltransferases

2009
The emerging role of symmetric dimethylarginine in vascular disease.
    Advances in clinical chemistry, 2009, Volume: 48

    Topics: Arginine; Cardiovascular Diseases; Homeostasis; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Renal Insufficiency

2009
The role of nitric oxide synthase inhibition by asymmetric dimethylarginine in the pathophysiology of preeclampsia.
    Gynecologic and obstetric investigation, 2010, Volume: 69, Issue:1

    Topics: Arginine; Biomarkers; Endothelium, Vascular; Female; Humans; Nitric Oxide Synthase; Pre-Eclampsia; Pregnancy

2010
The DDAH/ADMA pathway in the control of endothelial cell migration and angiogenesis.
    Biochemical Society transactions, 2009, Volume: 37, Issue:Pt 6

    Topics: Amidohydrolases; Animals; Apoptosis; Arginine; Cell Movement; Cell Proliferation; Endothelial Cells; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Humans; Neovascularization, Physiologic; Nitric Oxide Synthase; rho GTP-Binding Proteins; Signal Transduction; Stem Cells

2009
Stroke biomarkers: progress and challenges for diagnosis, prognosis, differentiation, and treatment.
    Clinical chemistry, 2010, Volume: 56, Issue:1

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Arginine; Biomarkers; Diffusion Magnetic Resonance Imaging; Glial Fibrillary Acidic Protein; Humans; Matrix Metalloproteinase 9; Nerve Growth Factors; Prognosis; Receptors, N-Methyl-D-Aspartate; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Stroke; Tomography, X-Ray Computed

2010
The biochemistry, measurement and current clinical significance of asymmetric dimethylarginine.
    Annals of clinical biochemistry, 2010, Volume: 47, Issue:Pt 1

    Topics: Amidohydrolases; Animals; Arginine; Biochemistry; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Metabolic Clearance Rate; Models, Biological; Nitric Oxide Synthase; Oxidative Stress; Prognosis

2010
[Homocysteine and asymmetric dimethylarginine (ADMA) in epilepsy].
    Przeglad lekarski, 2009, Volume: 66, Issue:8

    Topics: Anticonvulsants; Arginine; Carbamazepine; Epilepsy; Homocysteine; Humans; Nitric Oxide; Nitric Oxide Synthase; Valproic Acid

2009
Nitric oxide and oxidative stress in vascular disease.
    Pflugers Archiv : European journal of physiology, 2010, Volume: 459, Issue:6

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Arginine; Aryldialkylphosphatase; Biopterins; Calcium; Cardiovascular Diseases; Catalase; Electron Transport; Glutathione Peroxidase; Heme Oxygenase (Decyclizing); Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mitochondria; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Protein Multimerization; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Risk Factors; Superoxide Dismutase; Superoxides; Thioredoxins; Vascular Diseases; Xanthine Oxidase

2010
Asymmetric dimethylarginine as a mediator of vascular dysfunction and a marker of cardiovascular disease and mortality: an intriguing interaction with diabetes mellitus.
    Diabetes & vascular disease research, 2010, Volume: 7, Issue:2

    Topics: Arginine; Diabetic Angiopathies; Endothelium, Vascular; Humans

2010
Emerging interface between metabolic syndrome and asthma.
    American journal of respiratory cell and molecular biology, 2011, Volume: 44, Issue:3

    Topics: Animals; Arginase; Arginine; Asthma; Humans; Hyperinsulinism; Inflammation; Insulin; Insulin Resistance; Metabolic Syndrome; Mice; Mitochondria; Nitric Oxide Synthase Type III; Somatomedins; Th2 Cells

2011
Usefulness of cardiovascular biomarkers and cardiac imaging in systemic rheumatic diseases.
    Autoimmunity reviews, 2010, Volume: 9, Issue:12

    Topics: Arginine; Atherosclerosis; Biomarkers; C-Reactive Protein; Diagnostic Imaging; Early Diagnosis; High-Throughput Screening Assays; Humans; Rheumatic Diseases; Risk Factors; Serum Amyloid P-Component

2010
Effect of selected drugs on plasma asymmetric dimethylarginine (ADMA) levels.
    Die Pharmazie, 2010, Volume: 65, Issue:8

    Topics: Adrenergic beta-Antagonists; Amidohydrolases; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Arginine; Aspirin; Estrogens; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Receptors, Cytoplasmic and Nuclear; Vitamin A; Vitamin B Complex; Vitamins

2010
Post-challenge hyperglycaemia, nitric oxide production and endothelial dysfunction: the putative role of asymmetric dimethylarginine (ADMA).
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2011, Volume: 21, Issue:1

    Topics: Animals; Arginine; Diabetes Mellitus, Type 2; Endothelium, Vascular; Glucose; Glucose Tolerance Test; Heart Diseases; Humans; Hyperglycemia; Metabolic Diseases; Nitric Oxide; Oxidative Stress

2011
Pharmacological interventions on asymmetric dimethylarginine, a clinical marker of vascular disease.
    Current medicinal chemistry, 2011, Volume: 18, Issue:5

    Topics: Adrenergic Antagonists; Angiotensins; Arginine; Diabetes Complications; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperhomocysteinemia; Hypertension; Kidney Diseases; Microcirculation; Nitric Oxide Synthase Type III; Peroxisome Proliferator-Activated Receptors; Receptors, Cytoplasmic and Nuclear; Vascular Diseases

2011
L-arginine, NO and asymmetrical dimethylarginine in hypertension and type 2 diabetes.
    Frontiers in bioscience (Landmark edition), 2011, 01-01, Volume: 16, Issue:1

    Topics: Animals; Antihypertensive Agents; Arginine; Diabetes Mellitus, Type 2; Endothelium, Vascular; Humans; Hypertension; Insulin Resistance; Nitric Oxide; Nitric Oxide Synthase Type III; Prognosis

2011
The biology and therapeutic potential of the DDAH/ADMA pathway.
    Current pharmaceutical design, 2010, Volume: 16, Issue:37

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Molecular Targeted Therapy; Nitric Oxide; Nitric Oxide Synthase

2010
Novel endothelial biomarkers: implications for periodontal disease and CVD.
    Journal of dental research, 2011, Volume: 90, Issue:9

    Topics: Animals; Arginine; Biomarkers; Cardiovascular Diseases; Cell-Derived Microparticles; Endothelial Cells; Endothelium, Vascular; Gingivitis; Humans; Nitric Oxide Synthase; Periodontitis; Stem Cells

2011
Asymmetric dimethylarginine: clinical applications in pediatric medicine.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2011, Volume: 110, Issue:2

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Child, Preschool; Endothelium, Vascular; Enzyme Inhibitors; Humans; Infant; Nitric Oxide Synthase; Pediatrics; Reference Values; Risk Factors

2011
The role of asymmetric and symmetric dimethylarginines in renal disease.
    Nature reviews. Nephrology, 2011, Volume: 7, Issue:5

    Topics: Arginine; Humans; Kidney; Renal Insufficiency, Chronic; Risk Factors

2011
The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis.
    Nature reviews. Drug discovery, 2011, Volume: 10, Issue:4

    Topics: Amidohydrolases; Animals; Arginine; Cytoplasm; Drug Delivery Systems; Humans; Methylation; Nitric Oxide; Nitric Oxide Synthase; Protein Isoforms; Protein Processing, Post-Translational

2011
Oxidative stress and endothelial dysfunction in hypertension.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2011, Volume: 34, Issue:6

    Topics: Animals; Arginine; Endothelium, Vascular; Humans; Hypertension; NADPH Oxidases; Nitric Oxide Synthase Type III; Oxidative Stress; Prognosis; Reactive Oxygen Species; Xanthine Oxidase

2011
[Analysis of transporter function and development to clinical application].
    Seikagaku. The Journal of Japanese Biochemical Society, 2011, Volume: 83, Issue:4

    Topics: Aconitic Acid; Animals; Arginine; Guanidines; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperuricemia; Kidney; Organic Anion Transporters; Organic Cation Transport Proteins; Rats; Renal Insufficiency; Succinates

2011
Asymmetric dimethylarginine: a novel biomarker of gastric mucosal injury?
    World journal of gastroenterology, 2011, May-07, Volume: 17, Issue:17

    Topics: Animals; Arginine; Biomarkers; Gastric Mucosa; Helicobacter pylori; Humans; Nicotine; Nitric Oxide

2011
Nitric oxide (NO) and asymmetric dimethylarginine (ADMA): their pathophysiological role and involvement in intracerebral hemorrhage.
    Neurological research, 2011, Volume: 33, Issue:5

    Topics: Animals; Arginine; Cerebral Hemorrhage; Humans; Nitric Oxide; Nitric Oxide Synthase

2011
The biochemistry of asthma.
    Biochimica et biophysica acta, 2011, Volume: 1810, Issue:11

    Topics: Aldehyde Oxidoreductases; Animals; Arginase; Arginine; Asthma; Humans; Hydrogen-Ion Concentration; Nitrites

2011
Nitric oxide synthase derangements and hypertension in kidney disease.
    Current opinion in nephrology and hypertension, 2012, Volume: 21, Issue:1

    Topics: Amidohydrolases; Animals; Arginine; Chronic Disease; Disease Progression; Humans; Hypertension; Kidney; Kidney Diseases; Nitric Oxide; Nitric Oxide Synthase

2012
Peripheral hemorheological and vascular correlates of coronary blood flow.
    Clinical hemorheology and microcirculation, 2011, Volume: 49, Issue:1-4

    Topics: Arginine; Blood Flow Velocity; Chest Pain; Coronary Circulation; Diagnosis, Differential; Endothelium, Vascular; Female; Hemorheology; Humans; Hyperhomocysteinemia; Inflammation; Male; Microvessels; Myocardial Ischemia; Nitric Oxide; Platelet Activation; Syndrome; Vascular Resistance; Vasodilator Agents

2011
Asymmetric dimethylarginine and reactive oxygen species: unwelcome twin visitors to the cardiovascular and kidney disease tables.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 59, Issue:2

    Topics: Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Humans; Kidney Diseases; Rats; Reactive Oxygen Species; Risk Factors

2012
Cardiovascular involvement in psoriatic arthritis.
    Reumatismo, 2011, Nov-09, Volume: 63, Issue:3

    Topics: Antirheumatic Agents; Arginine; Arthritis, Psoriatic; Coronary Circulation; Coronary Disease; Cytokines; Heart Diseases; Humans; Inflammation; Microcirculation; Risk Factors; Tumor Necrosis Factor-alpha

2011
Association of circulating levels of asymmetric dimethylarginine (ADMA) with carotid intima-media thickness: evidence from 6168 participants.
    Ageing research reviews, 2013, Volume: 12, Issue:2

    Topics: Adult; Aged; Arginine; Carotid Intima-Media Thickness; Epidemiologic Studies; Female; Humans; Kidney Function Tests; Male; Middle Aged; Nitric Oxide Synthase; Renal Insufficiency, Chronic; Statistics as Topic

2013
Endogenous nitric oxide synthase inhibitors in the biology of disease: markers, mediators, and regulators?
    Arteriosclerosis, thrombosis, and vascular biology, 2012, Volume: 32, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Binding Sites; Binding, Competitive; Biomarkers; Cardiovascular Agents; Cardiovascular Diseases; Catalytic Domain; Enzyme Inhibitors; Humans; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine

2012
[Methylarginies-induced endothelial dysfunction in chronic kidney disease].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2012, Volume: 132, Issue:4

    Topics: Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Renal Insufficiency, Chronic; Risk Factors

2012
New directions in cardiovascular risk assessment: the role of secondary risk stratification markers.
    International journal of clinical practice, 2012, Volume: 66, Issue:7

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Adrenomedullin; Ankle Brachial Index; Arginine; Biomarkers; Blood Flow Velocity; C-Reactive Protein; Cardiovascular Diseases; Carotid Intima-Media Thickness; Early Diagnosis; Humans; Lipoprotein(a); Natriuretic Peptide, Brain; Peptide Fragments; Protein Precursors; Risk Assessment; Troponin; Vascular Calcification; Vasodilation

2012
Biomarkers in hemodialysis patients.
    Advances in clinical chemistry, 2012, Volume: 57

    Topics: Animals; Arginine; Biomarkers; Cardiovascular Physiological Phenomena; Cell Adhesion Molecules; Humans; Inflammation; Kidney Failure, Chronic; Natriuretic Peptide, Brain; Renal Dialysis; Troponin

2012
Biomarkers in pre-eclampsia: a novel approach to early detection of the disease.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2012, Volume: 32, Issue:7

    Topics: Antigens, CD; Arginine; Biomarkers; Endoglin; Female; Galectins; Homocysteine; Humans; Leptin; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; Pregnancy Trimester, First; Pregnancy-Associated Plasma Protein-A; Receptors, Cell Surface; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1

2012
The impact of asymmetric dimethylarginine (ADAMA), the endogenous nitric oxide (NO) synthase inhibitor, to the pathogenesis of gastric mucosal damage.
    Current pharmaceutical design, 2013, Volume: 19, Issue:1

    Topics: Animals; Apoptosis; Arginine; Gastric Mucosa; Gastrointestinal Tract; Helicobacter Infections; Helicobacter pylori; Humans; Inflammation; Nitric Oxide; Nitric Oxide Synthase; Rats; Risk Factors

2013
Cardiovascular risk in autoimmune disorders: role of asymmetric dimethylarginine.
    European journal of pharmacology, 2012, Dec-05, Volume: 696, Issue:1-3

    Topics: Animals; Arginine; Autoimmune Diseases; Cardiovascular Diseases; Humans; Risk

2012
Asymmetric dimethylarginine: a possible link between vascular disease and dementia.
    Current Alzheimer research, 2013, May-01, Volume: 10, Issue:4

    Topics: Arginine; Brain; Dementia; Endothelium; Enzyme Inhibitors; Humans; Neuroprotective Agents; Nitric Oxide; Oxidative Stress; Risk Factors; Vascular Diseases

2013
The role of dimethylarginine dimethylaminohydrolase (DDAH) in pulmonary fibrosis.
    The Journal of pathology, 2013, Volume: 229, Issue:2

    Topics: Amidohydrolases; Animals; Arginine; Enzyme Inhibitors; Humans; Idiopathic Pulmonary Fibrosis; Lung; Nitric Oxide; Nitric Oxide Synthase Type II; Signal Transduction

2013
Asymmetric dimethylarginine, endothelial dysfunction and renal disease.
    International journal of molecular sciences, 2012, Volume: 13, Issue:9

    Topics: Adult; Amidohydrolases; Arginine; Biomarkers; Cardiovascular Diseases; Child; Disease Progression; Endothelial Cells; Endothelium, Vascular; Humans; Kidney; Kidney Diseases; Kidney Transplantation; Nitric Oxide; Oxidative Stress; Risk Factors

2012
Asymmetric dimethylarginine as a surrogate marker of endothelial dysfunction and cardiovascular risk in patients with systemic rheumatic diseases.
    International journal of molecular sciences, 2012, Sep-26, Volume: 13, Issue:10

    Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Nitric Oxide; Nitric Oxide Synthase; Rheumatic Diseases; Risk Factors

2012
Roles of nitric oxide and asymmetric dimethylarginine in pregnancy and fetal programming.
    International journal of molecular sciences, 2012, Nov-09, Volume: 13, Issue:11

    Topics: Animals; Arginine; Female; Fetal Development; Humans; Metabolic Networks and Pathways; Nitric Oxide; Placenta; Placental Insufficiency; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects

2012
Beta blockers, nitric oxide, and cardiovascular disease.
    Current opinion in pharmacology, 2013, Volume: 13, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Antioxidants; Arginine; Cardiovascular Diseases; Humans; Nitric Oxide; Vasodilation

2013
Clinical and research markers of oxidative stress in chronic kidney disease.
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2013, Volume: 18, Issue:2

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Advanced Oxidation Protein Products; Arginine; Biomarkers; Clinical Trials as Topic; Deoxyguanosine; F2-Isoprostanes; Glutathione; Humans; Kidney; Lipid Peroxidation; Lipid Peroxides; Malondialdehyde; Oxidative Stress; Protein Carbonylation; Renal Insufficiency, Chronic

2013
Asymmetric dimethyarginine as marker and mediator in ischemic stroke.
    International journal of molecular sciences, 2012, Nov-28, Volume: 13, Issue:12

    Topics: Animals; Arginine; Biomarkers; Brain Ischemia; Cerebrovascular Circulation; Enzyme Inhibitors; Humans; Methylation; Nitric Oxide Synthase; Oxidative Stress; Protein Processing, Post-Translational; Stroke

2012
Asymmetric Dimethylarginine (ADMA): a promising biomarker for cardiovascular disease?
    Current topics in medicinal chemistry, 2013, Volume: 13, Issue:2

    Topics: Aging; Amidohydrolases; Arginine; Biomarkers; Cardiovascular Diseases; Cerebrovascular Disorders; Chromatography, High Pressure Liquid; Diabetes Complications; Enzyme-Linked Immunosorbent Assay; Humans; Hypertension; Mass Spectrometry; Nitric Oxide; Oxidative Stress; Reference Values; Risk Factors; Smoking

2013
A novel metabolic balance model for describing the metabolic disruption of and interactions between cardiovascular-related markers during acute myocardial infarction.
    Metabolism: clinical and experimental, 2013, Volume: 62, Issue:10

    Topics: Acute Disease; Adenosine Triphosphate; Amidohydrolases; Animals; Arginine; Biomarkers; Cardiovascular System; Kidney; Male; Myocardial Infarction; Rats; Rats, Sprague-Dawley

2013
Role of asymmetric dimethylarginine in cardiorenal syndrome.
    Current pharmaceutical design, 2014, Volume: 20, Issue:14

    Topics: Animals; Arginine; Cardio-Renal Syndrome; Cardiovascular Agents; Drug Delivery Systems; Humans; Nitric Oxide Synthase

2014
Asymmetric dimethylarginine and critical illness.
    Current opinion in clinical nutrition and metabolic care, 2014, Volume: 17, Issue:1

    Topics: Amidohydrolases; Arginine; Critical Illness; Enzyme Inhibitors; Heart Failure; Humans; Intensive Care Units; Nitric Oxide; Nitric Oxide Synthase; Risk Factors

2014
Is asymmetric dimethylarginine associated with being born small and large for gestational age?
    Antioxidants & redox signaling, 2014, May-20, Volume: 20, Issue:15

    Topics: Arginine; Biomarkers; Birth Weight; Cardiovascular Diseases; Female; Gestational Age; Humans; Metabolic Diseases; Pregnancy

2014
Increased circulatory asymmetric dimethylarginine and multiple organ failure: bile duct ligation in rat as a model.
    International journal of molecular sciences, 2014, Mar-05, Volume: 15, Issue:3

    Topics: Animals; Arginine; Bile Ducts; Disease Models, Animal; Fibrosis; Ligation; Liver; Liver Cirrhosis; Multiple Organ Failure; Rats

2014
The endothelial ADMA/NO pathway in hypoxia-related chronic respiratory diseases.
    BioMed research international, 2014, Volume: 2014

    Topics: Amidohydrolases; Animals; Arginine; Chronic Disease; Humans; Hypoxia; Nitric Oxide; Respiratory Tract Diseases

2014
Dimethylarginines ADMA and SDMA: the real water-soluble small toxins?
    Seminars in nephrology, 2014, Volume: 34, Issue:2

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Humans; Kidney Diseases; Water

2014
Restoration of asymmetric dimethylarginine-nitric oxide balance to prevent the development of hypertension.
    International journal of molecular sciences, 2014, Jul-02, Volume: 15, Issue:7

    Topics: Animals; Arginine; Humans; Hypertension; Nitric Oxide

2014
Endothelial (dys)function in lone atrial fibrillation.
    Current pharmaceutical design, 2015, Volume: 21, Issue:5

    Topics: Arginine; Atrial Fibrillation; Biomarkers; E-Selectin; Endocardium; Endothelium, Vascular; Humans; Predictive Value of Tests; Prognosis; Risk Factors; Thrombomodulin; von Willebrand Factor

2015
The association between systemic sclerosis, arginine and asymmetric dimethylarginine.
    Inflammation, 2015, Volume: 38, Issue:1

    Topics: Animals; Arginine; Case-Control Studies; Humans; Nitric Oxide; Scleroderma, Systemic

2015
Arginine metabolism in asthma.
    Immunology and allergy clinics of North America, 2014, Volume: 34, Issue:4

    Topics: Animals; Anti-Asthmatic Agents; Arginine; Asthma; Bronchial Hyperreactivity; Humans; Molecular Targeted Therapy; Nitric Oxide Synthase

2014
Recovery from acute kidney injury: the role of biomarkers.
    Nephron. Clinical practice, 2014, Volume: 127, Issue:1-4

    Topics: Acute Kidney Injury; Acute-Phase Proteins; Apoptosis Regulatory Proteins; Arginine; Biomarkers; Coronary Artery Bypass; Creatinine; Critical Care; Cytokine TWEAK; Diagnosis, Differential; Diuresis; Glomerular Filtration Rate; Graft Rejection; Hepatitis A Virus Cellular Receptor 1; Humans; Interleukin-18; Kidney; Kidney Transplantation; Lipocalin-2; Lipocalins; Membrane Glycoproteins; Membrane Proteins; Peptides; Postoperative Complications; Prognosis; Proto-Oncogene Proteins; Receptors, Virus; Recovery of Function; Renal Replacement Therapy; Reperfusion Injury; Severity of Illness Index; Trefoil Factor-3; Tumor Necrosis Factors

2014
Asymmetric Dimethylarginine (ADMA) in cardiovascular and renal disease.
    Clinica chimica acta; international journal of clinical chemistry, 2015, Feb-02, Volume: 440

    Topics: Arginine; Cardiovascular Diseases; Humans; Kidney Diseases; Kidney Transplantation; Nitric Oxide; Nitric Oxide Synthase; Proteinuria

2015
Nutritional factors in the prevention and management of coronary artery disease and heart failure.
    Nutrition (Burbank, Los Angeles County, Calif.), 2015, Volume: 31, Issue:2

    Topics: Alprostadil; Anti-Inflammatory Agents; Arginine; CD59 Antigens; Coronary Artery Disease; Diabetes Mellitus, Type 2; Epoprostenol; Fatty Acids, Essential; Fatty Acids, Unsaturated; Female; Folic Acid; Heart Failure; Humans; Hypertension; Lipoxins; Magnesium; Male; Middle Aged; Nitric Oxide; Nutritional Status; Serum Albumin; Vasodilation; Vitamin B 12; Vitamin B 6

2015
Liver plays a central role in asymmetric dimethylarginine-mediated organ injury.
    World journal of gastroenterology, 2015, May-07, Volume: 21, Issue:17

    Topics: Animals; Arginine; Biomarkers; Critical Illness; Humans; Liver; Liver Diseases; Multiple Organ Failure; Prognosis; Risk Factors; Signal Transduction; Up-Regulation

2015
Levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, and risk of coronary artery disease: A meta-analysis based on 4713 participants.
    European journal of preventive cardiology, 2016, Volume: 23, Issue:5

    Topics: Adult; Aged; Arginine; Biomarkers; Case-Control Studies; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Prognosis; Risk Assessment; Risk Factors; Up-Regulation

2016
A systematic review and meta-analysis of the effect of statins on plasma asymmetric dimethylarginine concentrations.
    Scientific reports, 2015, May-13, Volume: 5

    Topics: Arginine; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Publication Bias; Randomized Controlled Trials as Topic

2015
Asymmetric dimethylarginine and cardiovascular risk: systematic review and meta-analysis of 22 prospective studies.
    Journal of the American Heart Association, 2015, May-28, Volume: 4, Issue:6

    Topics: Arginine; Cardiovascular Diseases; Humans; Odds Ratio; Prospective Studies; Stroke

2015
Sodium Intake as a Modulator of Kidney Function.
    Current hypertension reviews, 2015, Volume: 11, Issue:1

    Topics: Angiotensin I; Arginine; Blood Pressure; Homeostasis; Humans; Kidney; Peptide Fragments; Sodium, Dietary

2015
Asymmetric Dimethylarginine: Clinical Significance and Novel Therapeutic Approaches.
    Current medicinal chemistry, 2015, Volume: 22, Issue:24

    Topics: Alzheimer Disease; Animals; Arginine; Cardiovascular Diseases; Diabetes Mellitus; Female; Humans; Hypercholesterolemia; Neoplasms; Pre-Eclampsia; Pregnancy; Renal Insufficiency, Chronic

2015
Homoarginine in the shadow of asymmetric dimethylarginine: from nitric oxide to cardiovascular disease.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Amidinotransferases; Animals; Arginine; Atherosclerosis; Endothelium, Vascular; Homoarginine; Humans; Nitric Oxide; Nitric Oxide Synthase Type III

2015
Asymmetric dimethylarginine as a mediator of vascular dysfunction in cirrhosis.
    World journal of gastroenterology, 2015, Aug-28, Volume: 21, Issue:32

    Topics: Amidohydrolases; Animals; Arginine; Hemodynamics; Humans; Hypertension, Portal; Liver; Liver Cirrhosis; Nitric Oxide; Nitric Oxide Synthase Type III; Portal Vein

2015
Diet in children with phenylketonuria and risk of cardiovascular disease: A narrative overview.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2016, Volume: 26, Issue:3

    Topics: Adiponectin; Arginine; Blood Pressure; Cardiovascular Diseases; Child; Cholesterol, HDL; Cholesterol, LDL; Diet; Homocysteine; Humans; Oxidative Stress; Pediatric Obesity; Phenylalanine; Phenylketonurias; Risk Factors

2016
Endothelial Dysfunction in Renal Failure: Current Update.
    Current medicinal chemistry, 2016, Volume: 23, Issue:19

    Topics: Arginine; Endothelium, Vascular; Humans; Nitric Oxide; Oxidative Stress; Renal Insufficiency; Uremia; Vascular Cell Adhesion Molecule-1; Vitamin D Deficiency

2016
Effect of asymmetric dimethylarginine (ADMA) on heart failure development.
    Nitric oxide : biology and chemistry, 2016, Apr-01, Volume: 54

    Topics: Amidohydrolases; Animals; Arginine; Heart Failure; Humans; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Peroxynitrous Acid; Signal Transduction; Superoxides

2016
Potential Signaling Pathways Involved in the Clinical Application of Oxymatrine.
    Phytotherapy research : PTR, 2016, Volume: 30, Issue:7

    Topics: Alkaloids; Arginine; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-bcl-2; Quinolizines; Signal Transduction; Sophora; STAT Transcription Factors; Toll-Like Receptors; Transforming Growth Factor beta

2016
When Is It Appropriate to Use Arginine in Critical Illness?
    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2016, Volume: 31, Issue:4

    Topics: Arginine; Critical Care; Critical Illness; Dietary Supplements; Humans

2016
The cytoskeleton as a novel target for treatment of renal fibrosis.
    Pharmacology & therapeutics, 2016, Volume: 166

    Topics: Actins; Animals; Arginine; Cytoskeleton; Disease Progression; Epithelial Cells; Fibrosis; Humans; Kidney Failure, Chronic; Podocytes; Renal Insufficiency, Chronic; rho-Associated Kinases

2016
Circulating Biomarkers of Diabetic Retinopathy: An Overview Based on Physiopathology.
    Journal of diabetes research, 2016, Volume: 2016

    Topics: Adrenomedullin; Arginine; Autoantibodies; Basement Membrane; Biomarkers; C-Reactive Protein; Collagen Type IV; Diabetic Retinopathy; E-Selectin; Endothelial Progenitor Cells; Extracellular Matrix; Glycation End Products, Advanced; Homocysteine; Humans; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-6; Laminin; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; MicroRNAs; Retinol-Binding Proteins, Plasma; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

2016
Nitric Oxide's Involvement in the Spectrum of Psychotic Disorders.
    Current medicinal chemistry, 2016, Volume: 23, Issue:24

    Topics: Antipsychotic Agents; Arginine; Brain; Clinical Trials as Topic; Humans; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase 5 Inhibitors; Psychotic Disorders; Schizophrenia; Sildenafil Citrate

2016
Role of Asymmetrical Dimethylarginine in Diabetic Microvascular Complications.
    Journal of cardiovascular pharmacology, 2016, Volume: 68, Issue:4

    Topics: Animals; Arginine; Biomarkers; Diabetes Mellitus; Diabetic Angiopathies; Enzyme Inhibitors; Humans; Nitric Oxide Synthase

2016
Asymmetric Dimethylarginine and Hepatic Encephalopathy: Cause, Effect or Association?
    Neurochemical research, 2017, Volume: 42, Issue:3

    Topics: Animals; Arginine; Brain; Cognition Disorders; Endothelium, Vascular; Hepatic Encephalopathy; Humans; Inflammation; Nitric Oxide Synthase; Nitrosation; Oxidative Stress

2017
Targeting on Asymmetric Dimethylarginine-Related Nitric Oxide-Reactive Oxygen Species Imbalance to Reprogram the Development of Hypertension.
    International journal of molecular sciences, 2016, Dec-02, Volume: 17, Issue:12

    Topics: Animals; Arginine; Humans; Hypertension; Kidney; Nitric Oxide; Reactive Oxygen Species

2016
Novel Pathophysiological Mechanisms in Hypertension.
    Advances in experimental medicine and biology, 2017, Volume: 956

    Topics: Animals; Antihypertensive Agents; Arginine; Biomarkers; Blood Pressure; Cytokines; Drug Resistance; Humans; Hypertension; Immunity, Innate; Inflammation Mediators; Renin-Angiotensin System; Signal Transduction

2017
Pathophysiological Role of Adiponectin, Leptin and Asymmetric Dimethylarginine in the Process of Atherosclerosis.
    Folia medica, 2016, 12-01, Volume: 58, Issue:4

    Topics: Adiponectin; Arginine; Atherosclerosis; C-Reactive Protein; E-Selectin; Endothelin-1; Humans; Intercellular Adhesion Molecule-1; Interleukin-8; Leptin; Nitric Oxide; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

2016
Oxidative Stress and Cardiovascular Aging: Interaction Between NRF-2 and ADMA.
    Current cardiology reviews, 2017, Volume: 13, Issue:3

    Topics: Aging; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction

2017
Toxic Dimethylarginines: Asymmetric  Dimethylarginine (ADMA) and Symmetric  Dimethylarginine (SDMA).
    Toxins, 2017, 03-06, Volume: 9, Issue:3

    Topics: Animals; Arginine; Humans; Toxins, Biological

2017
Interplay between Oxidative Stress and Nutrient Sensing Signaling in the Developmental Origins of Cardiovascular Disease.
    International journal of molecular sciences, 2017, Apr-15, Volume: 18, Issue:4

    Topics: Animals; Arginine; Cardiovascular Diseases; Disease Models, Animal; Energy Metabolism; Humans; Nitric Oxide; Nutritional Physiological Phenomena; Oxidative Stress; Reactive Oxygen Species; Signal Transduction

2017
The issue of plasma asymmetric dimethylarginine reference range - A systematic review and meta-analysis.
    PloS one, 2017, Volume: 12, Issue:5

    Topics: Arginine; Chromatography, High Pressure Liquid; Confidence Intervals; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Reference Values

2017
An Expanding Role of Biomarkers in Pulmonary Arterial Hypertension.
    Current pharmaceutical biotechnology, 2017, Volume: 18, Issue:6

    Topics: Arginine; Biomarkers; Endothelins; Humans; Hypertension, Pulmonary; Prognosis; Sensitivity and Specificity; Severity of Illness Index; von Willebrand Factor

2017
Polycystic ovarian syndrome-associated cardiovascular complications: An overview of the association between the biochemical markers and potential strategies for their prevention and elimination.
    Diabetes & metabolic syndrome, 2017, Volume: 11 Suppl 2

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Female; Glycation End Products, Advanced; Homocysteine; Humans; Oxidative Stress; Polycystic Ovary Syndrome; Receptor for Advanced Glycation End Products; von Willebrand Factor

2017
Using Chemistry to Target Neuroblastoma.
    ACS chemical neuroscience, 2017, 10-18, Volume: 8, Issue:10

    Topics: Animals; Arginine; Humans; Neural Crest; Neuroblastoma; Oncogene Proteins; Reactive Oxygen Species; Signal Transduction

2017
Prognostic efficacy of circulating asymmetric dimethylarginine in patients with peripheral arterial disease: A meta-analysis of prospective cohort studies.
    Vascular, 2018, Volume: 26, Issue:3

    Topics: Arginine; Atherosclerosis; Biomarkers; Female; Humans; Male; Middle Aged; Peripheral Arterial Disease; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Factors

2018
AGXT2: An unnegligible aminotransferase in cardiovascular and urinary systems.
    Journal of molecular and cellular cardiology, 2017, Volume: 113

    Topics: Animals; Arginine; Cardiovascular Diseases; Cardiovascular System; Humans; Kidney Diseases; Transaminases

2017
Nitric oxide bioavailability dysfunction involves in atherosclerosis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97

    Topics: Animals; Arginine; Atherosclerosis; Biological Availability; Cardiovascular Diseases; Endothelium, Vascular; Humans; Nitric Oxide; Obesity; Oxidative Stress; Smoking; Vasodilation

2018
Association of Circulating Levels of ADMA with Carotid Intima-Media Thickness in Patients with CKD: a Systematic Review and Meta-Analysis.
    Kidney & blood pressure research, 2018, Volume: 43, Issue:1

    Topics: Arginine; Atherosclerosis; Cardiovascular Diseases; Carotid Intima-Media Thickness; Humans; Renal Insufficiency, Chronic

2018
Asymmetric Dimethyl Arginine as a Biomarker of Atherosclerosis in Rheumatoid Arthritis.
    Mediators of inflammation, 2018, Volume: 2018

    Topics: Animals; Arginine; Arthritis, Rheumatoid; Atherosclerosis; Biomarkers; Humans

2018
Asymmetric dimethylarginine (ADMA) as an important risk factor for the increased cardiovascular diseases and heart failure in chronic kidney disease.
    Nitric oxide : biology and chemistry, 2018, 08-01, Volume: 78

    Topics: Amidohydrolases; Animals; Arginine; Endothelium, Vascular; Heart Failure; Humans; Nitric Oxide Synthase; omega-N-Methylarginine; Renal Insufficiency, Chronic; Risk Factors; Signal Transduction

2018
Systemic concentrations of asymmetric dimethylarginine (ADMA) in chronic obstructive pulmonary disease (COPD): state of the art.
    Amino acids, 2018, Volume: 50, Issue:9

    Topics: Animals; Arginine; Humans; Nitric Oxide Synthase; Oxidative Stress; Pulmonary Disease, Chronic Obstructive

2018
The clinical effects of l-arginine and asymmetric dimethylarginine: implications for treatment in secondary Raynaud's phenomenon.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2019, Volume: 33, Issue:3

    Topics: Arginine; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Raynaud Disease; Scleroderma, Systemic; Vasodilation

2019
Asymmetric dimethylarginine levels in preeclampsia - Systematic review and meta-analysis.
    Placenta, 2018, Volume: 69

    Topics: Arginine; Biomarkers; Female; Humans; Pre-Eclampsia; Pregnancy

2018
Asymmetric dimethylarginine and angiogenesis: biological significance.
    International angiology : a journal of the International Union of Angiology, 2018, Volume: 37, Issue:6

    Topics: Animals; Arginine; Atherosclerosis; Cardiovascular Diseases; Endothelial Cells; Humans; Neovascularization, Pathologic; Neovascularization, Physiologic; Plaque, Atherosclerotic; Signal Transduction; Up-Regulation

2018
Association of l-Arginine Supplementation with Markers of Endothelial Function in Patients with Cardiovascular or Metabolic Disorders: A Systematic Review and Meta-Analysis.
    Nutrients, 2018, Dec-20, Volume: 11, Issue:1

    Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Diabetes Mellitus; Dietary Supplements; Endothelium, Vascular; Female; Humans; Hyperemia; Male; Middle Aged; Nitrates; Nitrites; Obesity; Treatment Outcome

2018
Elevated circulating asymmetric dimethylarginine levels in rheumatoid arthritis: a systematic review and meta-analysis.
    Amino acids, 2019, Volume: 51, Issue:5

    Topics: Arginine; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Humans; Risk Factors

2019
An update on arginine in sickle cell disease.
    Expert review of hematology, 2019, Volume: 12, Issue:4

    Topics: Anemia, Sickle Cell; Animals; Arginine; Hemolysis; Humans; Nitric Oxide; Nitric Oxide Synthase Type III

2019
Mortality in critical illness: The impact of asymmetric dimethylarginine on survival-A systematic review and meta-analysis.
    Acta anaesthesiologica Scandinavica, 2019, Volume: 63, Issue:6

    Topics: Area Under Curve; Arginine; Cause of Death; Critical Illness; Humans; Intensive Care Units; Quality Assurance, Health Care

2019
Relationship between Serum Asymmetric Dimethylarginine Level and Microvascular Complications in Diabetes Mellitus: A Meta-Analysis.
    BioMed research international, 2019, Volume: 2019

    Topics: Arginine; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Female; Humans; Male; Risk Factors

2019
Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases.
    Scientific reports, 2019, 04-01, Volume: 9, Issue:1

    Topics: Arginine; Biomarkers; Case-Control Studies; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Rheumatic Diseases

2019
Asymmetric dimethylarginine: An crucial regulator in tissue fibrosis.
    European journal of pharmacology, 2019, Jul-05, Volume: 854

    Topics: Animals; Arginine; Fibrosis; Humans

2019
Testosterone Deficiency and Endothelial Dysfunction: Nitric Oxide, Asymmetric Dimethylarginine, and Endothelial Progenitor Cells.
    Sexual medicine reviews, 2019, Volume: 7, Issue:4

    Topics: Arginine; Cyclic Nucleotide Phosphodiesterases, Type 5; Endothelial Progenitor Cells; Endothelium, Vascular; Humans; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Testosterone; Vasculitis

2019
Genetic regulation of dimethylarginines and endothelial dysfunction in rheumatoid arthritis.
    Amino acids, 2019, Volume: 51, Issue:7

    Topics: Arginine; Arthritis, Rheumatoid; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Endothelium, Vascular; Humans; Inflammation; Nitric Oxide; Nitric Oxide Synthase; Polymorphism, Single Nucleotide; Transaminases

2019
The Role of Nitric Oxide, ADMA, and Homocysteine in The Etiopathogenesis of Preeclampsia-Review.
    International journal of molecular sciences, 2019, Jun-05, Volume: 20, Issue:11

    Topics: Arginine; Female; Homocysteine; Humans; Nitric Oxide; Pre-Eclampsia; Pregnancy; Signal Transduction

2019
New horizons in arginine metabolism, ageing and chronic disease states.
    Age and ageing, 2019, 11-01, Volume: 48, Issue:6

    Topics: Aged; Aging; Arginine; Chronic Disease; Homoarginine; Humans

2019
The Biological Axis of Protein Arginine Methylation and Asymmetric Dimethylarginine.
    International journal of molecular sciences, 2019, Jul-06, Volume: 20, Issue:13

    Topics: Animals; Arginine; Humans; Metabolome; Methylation; Protein-Arginine N-Methyltransferases; Proteins

2019
Asymmetric (ADMA) and Symmetric (SDMA) Dimethylarginines in Chronic Kidney Disease: A Clinical Approach.
    International journal of molecular sciences, 2019, Jul-26, Volume: 20, Issue:15

    Topics: Aging; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Metabolic Networks and Pathways; Molecular Targeted Therapy; Prognosis; Renal Dialysis; Renal Insufficiency, Chronic

2019
The Second Life of Methylarginines as Cardiovascular Targets.
    International journal of molecular sciences, 2019, Sep-17, Volume: 20, Issue:18

    Topics: Amidohydrolases; Animals; Arginine; Biological Transport; Biomarkers; Cardiovascular Diseases; Cardiovascular System; Disease Susceptibility; Energy Metabolism; Humans; Molecular Targeted Therapy

2019
Uremic Toxin-Targeting as a Therapeutic Strategy for Preventing Cardiorenal Syndrome.
    Circulation journal : official journal of the Japanese Circulation Society, 2019, 12-25, Volume: 84, Issue:1

    Topics: Arginine; Cardio-Renal Syndrome; Glycation End Products, Advanced; Humans; Methylamines; Renal Insufficiency, Chronic

2019
Intraplatelet L-Arginine-Nitric Oxide Metabolic Pathway: From Discovery to Clinical Implications in Prevention and Treatment of Cardiovascular Disorders.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Amidohydrolases; Arginine; Blood Platelets; Cardiovascular Diseases; Endothelium, Vascular; Humans; Metabolic Networks and Pathways; Nitric Oxide; Nitric Oxide Synthase; Risk Factors

2020
Prognostic Value of Asymmetric Dimethylarginine in Patients with Heart Failure: A Systematic Review and Meta-analysis.
    BioMed research international, 2020, Volume: 2020

    Topics: Aged; Arginine; Heart Failure; Humans; Middle Aged; Prognosis

2020
Activation of arginase II by asymmetric dimethylarginine and homocysteine in hypertensive rats induced by hypoxia: a new model of nitric oxide synthesis regulation in hypertensive processes?
    Hypertension research : official journal of the Japanese Society of Hypertension, 2021, Volume: 44, Issue:3

    Topics: Animals; Arginase; Arginine; Disease Models, Animal; Homocysteine; Hypertension; Hypoxia; Nitric Oxide; Rats; Rats, Wistar

2021
Asymmetric Dimethylarginine: a Key Player in the Pathophysiology of Endothelial Dysfunction, Vascular Inflammation and Atherosclerosis in Rheumatoid Arthritis?
    Current pharmaceutical design, 2021, Volume: 27, Issue:18

    Topics: Arginine; Arthritis, Rheumatoid; Atherosclerosis; Endothelial Cells; Endothelium, Vascular; Humans; Inflammation; Nitric Oxide

2021
Prognostic value of asymmetric dimethylarginine in patients with coronary artery disease: A meta-analysis.
    Nitric oxide : biology and chemistry, 2021, 05-01, Volume: 109-110

    Topics: Arginine; Biomarkers; Coronary Artery Disease; Humans; Prognosis

2021
A systematic review of the correlation between serum asymmetric dimethylarginine, carotid atherosclerosis and ischaemic stroke.
    European journal of clinical investigation, 2021, Volume: 51, Issue:8

    Topics: Arginine; Carotid Artery Diseases; Humans; Ischemic Stroke

2021
Asymmetric dimethylarginine level as biomarkers of cardiovascular or all-cause mortality in patients with chronic kidney disease: a meta-analysis.
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2021, Volume: 26, Issue:7

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Cause of Death; Humans; Mortality; Renal Insufficiency, Chronic

2021
Increasing the Power of Polyphenols through Nanoencapsulation for Adjuvant Therapy against Cardiovascular Diseases.
    Molecules (Basel, Switzerland), 2021, Jul-30, Volume: 26, Issue:15

    Topics: Antioxidant Response Elements; Antioxidants; Arginine; Cardiotonic Agents; Diabetes Mellitus; Drug Carriers; Drug Compounding; Dyslipidemias; Gene Expression Regulation; Humans; Hypertension; Myocardial Ischemia; Nanocapsules; NF-E2-Related Factor 2; Nitric Oxide; Oxidative Stress; Polyphenols; Signal Transduction

2021
An updated systematic review and meta-analysis of the effect of statins on asymmetric dimethylarginine.
    Nitric oxide : biology and chemistry, 2022, 03-01, Volume: 120

    Topics: Arginine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors

2022
A new perspective on NO pathway in sepsis and ADMA lowering as a potential therapeutic approach.
    Critical care (London, England), 2022, 08-12, Volume: 26, Issue:1

    Topics: Animals; Arginine; Humans; Ischemia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Sepsis

2022
Asymmetric dimethylarginine and gestational diabetes mellitus: a systematic review and meta-analysis.
    Endocrine, 2023, Volume: 80, Issue:2

    Topics: Arginine; Cardiovascular Diseases; Diabetes, Gestational; Female; Humans; Postpartum Period; Pregnancy

2023

Trials

220 trial(s) available for n,n-dimethylarginine and arginine

ArticleYear
Concentration of dimethyl-L-arginine in the plasma of patients with end-stage renal failure.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1996, Volume: 11, Issue:12

    Topics: Adult; Aged; Arginine; Chromatography, High Pressure Liquid; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Uremia

1996
Increased endogenous nitric oxide synthase inhibitor in patients with congestive heart failure.
    Life sciences, 1998, Volume: 62, Issue:26

    Topics: Arginine; Echocardiography; Enzyme Inhibitors; Female; Heart Failure; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II

1998
Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia.
    Circulation, 1998, Nov-03, Volume: 98, Issue:18

    Topics: Arginine; Double-Blind Method; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Injections, Intravenous; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Osmolar Concentration; Risk Factors

1998
Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease.
    Journal of the American College of Cardiology, 1998, Volume: 32, Issue:5

    Topics: Aged; Aged, 80 and over; Alprostadil; Arginine; Arterial Occlusive Diseases; Blood Flow Velocity; Chronic Disease; Cyclic GMP; Double-Blind Method; Exercise Test; Female; Femoral Artery; Follow-Up Studies; Humans; Infusions, Intravenous; Intermittent Claudication; Leg; Male; Middle Aged; Nitrates; Nitric Oxide; Peripheral Vascular Diseases; Treatment Outcome; Ultrasonography, Doppler, Duplex; Vasodilation; Vasodilator Agents

1998
Asymmetric dimethylarginine plasma concentrations differ in patients with end-stage renal disease: relationship to treatment method and atherosclerotic disease.
    Journal of the American Society of Nephrology : JASN, 1999, Volume: 10, Issue:3

    Topics: Adult; Aged; Analysis of Variance; Arginine; Arteriosclerosis; Female; Humans; Kidney Failure, Chronic; Kidney Function Tests; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Prognosis; Reference Values; Renal Dialysis; Severity of Illness Index

1999
Effects of some guanidino compounds on human cerebral arteries.
    Stroke, 1999, Volume: 30, Issue:10

    Topics: Adult; Aged; Arginine; Enzyme Inhibitors; Female; Guanidines; Humans; Male; Methylguanidine; Middle Aged; Middle Cerebral Artery; Nitric Oxide Synthase; omega-N-Methylarginine; Vasoconstrictor Agents; Vasodilator Agents

1999
Acute elevations of plasma asymmetric dimethylarginine and impaired endothelial function in response to a high-fat meal in patients with type 2 diabetes.
    Arteriosclerosis, thrombosis, and vascular biology, 2000, Volume: 20, Issue:9

    Topics: Adult; Aged; Arginine; Diabetes Mellitus, Type 2; Dietary Fats; Endothelium, Vascular; Female; Humans; Lipids; Male; Middle Aged; Triglycerides; Vasodilation

2000
Endothelium-dependent vasodilation is independent of the plasma L-arginine/ADMA ratio in men with stable angina: lack of effect of oral L-arginine on endothelial function, oxidative stress and exercise performance.
    Journal of the American College of Cardiology, 2001, Volume: 38, Issue:2

    Topics: Administration, Oral; Angina Pectoris; Arginine; Dinoprost; Double-Blind Method; Endothelium, Vascular; Exercise; Exercise Test; F2-Isoprostanes; Forearm; Heart Rate; Humans; Injections, Intra-Arterial; Male; Middle Aged; Oxidative Stress; Regional Blood Flow; Vasodilation

2001
Metformin treatment lowers asymmetric dimethylarginine concentrations in patients with type 2 diabetes.
    Metabolism: clinical and experimental, 2002, Volume: 51, Issue:7

    Topics: Arginine; Blood Glucose; Creatinine; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Sulfonylurea Compounds; Treatment Outcome

2002
Angiotensin converting enzyme inhibition and angiotensin II AT1-receptor blockade reduce the levels of asymmetrical N(G), N(G)-dimethylarginine in human essential hypertension.
    American journal of hypertension, 2002, Volume: 15, Issue:7 Pt 1

    Topics: Acrylates; Adult; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arginine; Blood Pressure; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Enalapril; Endothelium, Vascular; Humans; Hypertension; Imidazoles; Male; Receptor, Angiotensin, Type 1; Thiophenes

2002
Relationship between salt intake, nitric oxide and asymmetric dimethylarginine and its relevance to patients with end-stage renal disease.
    Blood purification, 2002, Volume: 20, Issue:5

    Topics: Arginine; Blood Pressure; Cardiovascular Diseases; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Renal Dialysis; Risk Factors; Sodium Chloride

2002
Long-term angiotensin-converting enzyme inhibition reduces plasma asymmetric dimethylarginine and improves endothelial nitric oxide bioavailability and coronary microvascular function in patients with syndrome X.
    The American journal of cardiology, 2002, Nov-01, Volume: 90, Issue:9

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Arginine; Biological Availability; Coronary Circulation; Double-Blind Method; Enalapril; Endothelium, Vascular; Exercise Test; Female; Hemodynamics; Humans; Male; Microcirculation; Microvascular Angina; Middle Aged; Nitric Oxide; Statistics as Topic; Time; Treatment Outcome; von Willebrand Factor

2002
ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins.
    Cardiovascular research, 2003, Volume: 57, Issue:1

    Topics: Aged; Analysis of Variance; Arginine; Arterial Occlusive Diseases; Double-Blind Method; Female; Folic Acid; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nitric Oxide Synthase; Oxidative Stress; Peripheral Vascular Diseases; Vitamin B 12; Vitamin B 6; Vitamins

2003
Increased levels of asymmetric dimethylarginine in populations at risk for atherosclerotic disease. Effects of pravastatin.
    Atherosclerosis, 2003, Volume: 166, Issue:2

    Topics: Arginine; Arteriosclerosis; Cholesterol, LDL; Diabetes Mellitus, Type 1; Female; Humans; Hypercholesterolemia; Incidence; Male; Pravastatin; Predictive Value of Tests; Probability; Reference Values; Risk Assessment; Sensitivity and Specificity

2003
Effect of high-dose statin treatment on plasma concentrations of endogenous nitric oxide synthase inhibitors.
    Journal of cardiovascular pharmacology, 2003, Volume: 41, Issue:2

    Topics: Aged; Analysis of Variance; Arginine; Azo Compounds; Chi-Square Distribution; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Nitric Oxide Synthase

2003
Acute intravenous L-arginine infusion decreases endothelin-1 levels and improves endothelial function in patients with angina pectoris and normal coronary arteriograms: correlation with asymmetric dimethylarginine levels.
    Circulation, 2003, Jan-28, Volume: 107, Issue:3

    Topics: Angina Pectoris; Arginine; Blood Pressure; Coronary Angiography; Cyclic GMP; Endothelin-1; Endothelium, Vascular; Female; Forearm; Humans; Infusions, Intravenous; Insulin; Male; Middle Aged; Nitric Oxide; Regional Blood Flow; Syndrome

2003
Oestrogen replacement therapy lowers plasma levels of asymmetrical dimethylarginine in healthy postmenopausal women.
    Clinical science (London, England : 1979), 2003, Volume: 105, Issue:1

    Topics: Analysis of Variance; Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Double-Blind Method; Estrogen Replacement Therapy; Estrogens, Conjugated (USP); Female; Humans; Hysterectomy; Middle Aged; Nitric Oxide Synthase; Postmenopause; Protein Isoforms; Raloxifene Hydrochloride; Risk Factors; Selective Estrogen Receptor Modulators; Sensitivity and Specificity

2003
Folic acid treatment reduces elevated plasma levels of asymmetric dimethylarginine in hyperhomocysteinaemic subjects.
    The British journal of nutrition, 2003, Volume: 89, Issue:3

    Topics: Adult; Aged; Arginine; Biomarkers; Dietary Supplements; Enzyme Inhibitors; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nitric Oxide Synthase

2003
Effects of simvastatin and L-arginine on vasodilation, nitric oxide metabolites and endogenous NOS inhibitors in hypercholesterolemic subjects.
    Free radical research, 2003, Volume: 37, Issue:5

    Topics: Anticholesteremic Agents; Arginine; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Free Radicals; Humans; Hypercholesterolemia; Lipids; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; S-Nitrosothiols; Simvastatin; Time Factors; Vasodilation

2003
Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase.
    Arteriosclerosis, thrombosis, and vascular biology, 2003, Aug-01, Volume: 23, Issue:8

    Topics: Adult; Amidohydrolases; Arginine; Blood Pressure; Cardiac Output; Double-Blind Method; Heart Rate; Humans; Hypertension; Injections, Intravenous; Male; Vascular Resistance

2003
Hyperhomocysteinaemia is not associated with increased levels of asymmetric dimethylarginine in patients with ischaemic heart disease.
    European journal of clinical investigation, 2003, Volume: 33, Issue:7

    Topics: Adult; Arginine; Female; Folic Acid; Humans; Hyperhomocysteinemia; Male; Middle Aged; Myocardial Ischemia; Nitric Oxide Synthase; Pyridoxine; Vitamin B 12

2003
Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine.
    Circulation, 2003, Aug-26, Volume: 108, Issue:8

    Topics: Adult; Age Factors; Aged; Arginine; Arteriosclerosis; Brachial Artery; Endothelium, Vascular; Female; Homocysteine; Homocystine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Peripheral Vascular Diseases; Regional Blood Flow; Regression Analysis; Vasodilation

2003
Increased concentrations of homocysteine and asymmetric dimethylarginine and decreased concentrations of nitric oxide in the plasma of patients with Alzheimer's disease.
    Neurobiology of aging, 2003, Volume: 24, Issue:7

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Arginine; Enzyme Inhibitors; Female; Homocysteine; Humans; Male; Matched-Pair Analysis; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Reference Values; Statistics as Topic

2003
Effect of hormone replacement therapy on plasma levels of the cardiovascular risk factor asymmetric dimethylarginine: a randomized, placebo-controlled 12-week study in healthy early postmenopausal women.
    The Journal of clinical endocrinology and metabolism, 2003, Volume: 88, Issue:9

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Dydrogesterone; Estradiol; Estrogen Replacement Therapy; Female; Humans; Isomerism; Middle Aged; Progesterone Congeners; Promegestone; Risk Factors; Spectrometry, Fluorescence

2003
Impact of vitamin E on plasma asymmetric dimethylarginine (ADMA) in chronic kidney disease (CKD): a pilot study.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2003, Volume: 18, Issue:11

    Topics: Adult; Aged; alpha-Tocopherol; Antioxidants; Arginine; Chronic Disease; Female; Humans; Kidney; Kidney Diseases; Male; Middle Aged; Oxidative Stress; Pilot Projects

2003
Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans.
    Circulation, 2004, Jan-20, Volume: 109, Issue:2

    Topics: Arginine; Cardiac Output; Cross-Over Studies; Cyclic GMP; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Hemodynamics; Humans; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Vascular Resistance

2004
Asymmetrical dimethylarginine (ADMA) and risk of acute coronary events. Does statin treatment influence plasma ADMA levels?
    Atherosclerosis. Supplements, 2003, Volume: 4, Issue:4

    Topics: Acute Disease; Adult; Aged; Arginine; Atorvastatin; Biomarkers; Blood Glucose; Case-Control Studies; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Double-Blind Method; Endothelium, Vascular; Enzyme Inhibitors; Female; Finland; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Male; Middle Aged; Prospective Studies; Pyrroles; Risk Factors; Simvastatin; Statistics as Topic; Triglycerides

2003
Acute Escherichia coli endotoxaemia decreases the plasma l-arginine/asymmetrical dimethylarginine ratio in humans.
    Clinical science (London, England : 1979), 2004, Volume: 106, Issue:6

    Topics: Acute Disease; Arginine; Blood Pressure; Body Temperature; Double-Blind Method; Endotoxemia; Escherichia coli Infections; Heart Rate; Humans; Leukocyte Count; Lipopolysaccharides; Male; Nitric Oxide Synthase

2004
Plasma asymmetric dimethylarginine modifies the effect of pravastatin on myocardial blood flow in young adults.
    Vascular medicine (London, England), 2003, Volume: 8, Issue:3

    Topics: Adenosine; Adult; Anticholesteremic Agents; Arginine; Blood Flow Velocity; Coronary Circulation; Double-Blind Method; Enzyme Inhibitors; Humans; Hyperemia; Male; Nitric Oxide Synthase; Pravastatin; Regional Blood Flow; Tomography, Emission-Computed

2003
Fenofibrate increases the L-arginine:ADMA ratio by increase of L-arginine concentration but has no effect on ADMA concentration.
    Atherosclerosis, 2004, Volume: 173, Issue:2

    Topics: Adult; Arginine; Biomarkers; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Fenofibrate; Follow-Up Studies; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Probability; Reference Values; Risk Assessment; Severity of Illness Index; Treatment Outcome

2004
Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension.
    American heart journal, 2004, Volume: 148, Issue:1

    Topics: Angiotensin-Converting Enzyme Inhibitors; Arginine; Captopril; Enalapril; Female; Humans; Hypertension; Lipid Peroxidation; Lipoproteins, LDL; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Oxidative Stress

2004
Asymmetric dimethyl arginine and symmetric dimethyl arginine levels in infants with persistent pulmonary hypertension of the newborn.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2004, Volume: 5, Issue:6

    Topics: Arginine; Chromatography, High Pressure Liquid; Cohort Studies; Female; Humans; Hypertension, Pulmonary; Infant, Newborn; Intensive Care Units, Pediatric; Male; Nitric Oxide Synthase

2004
Elevated plasma concentration of asymmetric dimethylarginine that is reduced by single dose testosterone administration in idiopathic hypogonadotropic hypogonadism patients.
    The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:3

    Topics: Adult; Androgens; Arginine; Humans; Hypogonadism; Male; Nitrates; Nitric Oxide; Nitrites; Testosterone

2005
Home-based exercise training modulates pro-oxidant substrates in patients with chronic heart failure.
    European journal of heart failure, 2005, Mar-02, Volume: 7, Issue:2

    Topics: Adult; Arginine; Cross-Over Studies; Exercise; Female; Heart Failure; Humans; Hypoxanthine; Male; Middle Aged; Nitrates; Nitrites; Xanthine

2005
L-arginine improves the symptoms of strokelike episodes in MELAS.
    Neurology, 2005, Feb-22, Volume: 64, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Amino Acids; Arginine; Cerebral Arteries; Child; Child, Preschool; Cholesterol; Cyclic GMP; Female; Headache; Humans; Male; MELAS Syndrome; Nitric Oxide; Paresis; Seizures; Stroke; Treatment Outcome; Vasodilation; Vision Disorders; Vomiting

2005
Modulation of asymmetric dimethylarginine in critically ill patients receiving intensive insulin treatment: a possible explanation of reduced morbidity and mortality?
    Critical care medicine, 2005, Volume: 33, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Arginine; Critical Illness; Female; Humans; Insulin; Male; Middle Aged; Morbidity; Nitric Oxide Synthase; Prospective Studies; Regression Analysis; Risk Factors; Survival Rate

2005
[Changes of serum asymmetric dimethylarginine in essential hypertension before and after the treatment].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2005, Volume: 30, Issue:1

    Topics: Adult; Aged; Antihypertensive Agents; Arginine; Enalapril; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase

2005
Plasma asymmetric dimethylarginine (ADMA) concentration is independently associated with carotid intima-media thickness and plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) concentration in patients with mild-to-moderate renal failure.
    Kidney international, 2005, Volume: 68, Issue:5

    Topics: Adult; Aged; Antioxidants; Arginine; Biomarkers; C-Reactive Protein; Carotid Artery Diseases; Female; Homocysteine; Humans; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Oxidative Stress; Solubility; Tunica Intima; Tunica Media; Ultrasonography; Vascular Cell Adhesion Molecule-1

2005
Long-term use of vitamin E-coated polysulfone membrane reduces oxidative stress markers in haemodialysis patients.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2005, Volume: 20, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Arginine; Biomarkers; Coated Materials, Biocompatible; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic; Lipoproteins, LDL; Male; Membranes, Artificial; Middle Aged; Nitric Oxide Synthase; Oxidative Stress; Polymers; Prognosis; Renal Dialysis; Sulfones; Time Factors; Vitamin E

2005
Dissociation between the short-term effects of nocturnal hemodialysis on endothelium dependent vasodilation and plasma ADMA.
    Arteriosclerosis, thrombosis, and vascular biology, 2005, Volume: 25, Issue:12

    Topics: Adult; Appointments and Schedules; Arginine; Circadian Rhythm; Endothelium, Vascular; Female; Humans; Kidney Failure, Chronic; Male; Renal Dialysis; Vasodilation

2005
Free fatty acids do not acutely increase asymmetrical dimethylarginine concentrations.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2005, Volume: 37, Issue:12

    Topics: Adult; Arginine; Blood Pressure; Endothelial Cells; Endothelium, Vascular; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Humans; Insulin Resistance; Male; Reference Values; Statistics, Nonparametric; Umbilical Veins

2005
Effect of fenofibrate on the level of asymmetric dimethylarginine in individuals with hypertriglyceridemia.
    European journal of clinical pharmacology, 2006, Volume: 62, Issue:3

    Topics: Adult; Anticholesteremic Agents; Arginine; Blood Flow Velocity; Brachial Artery; Cholesterol; Cholesterol, HDL; Diet; Endothelium, Vascular; Female; Fenofibrate; Humans; Hypertriglyceridemia; Male; Malondialdehyde; Middle Aged; Nitric Oxide; Treatment Outcome; Triglycerides; Tumor Necrosis Factor-alpha; Vasodilation

2006
No effect of B vitamins on ADMA levels in patients at increased cardiovascular risk.
    Clinical endocrinology, 2006, Volume: 64, Issue:5

    Topics: Adolescent; Adult; Arginine; Atherosclerosis; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Female; Folic Acid; Humans; Hyperhomocysteinemia; Linear Models; Male; Middle Aged; Pyridoxine; Risk Factors; Time Factors; Treatment Failure; Vitamin B Complex

2006
Plasma markers of NO synthase activity in women after ovarian hyperstimulation: influence of estradiol on ADMA.
    Vascular medicine (London, England), 2006, Volume: 11, Issue:1

    Topics: Adult; Arginine; Cells, Cultured; Endothelial Cells; Estradiol; Female; Follicle Stimulating Hormone; Follicular Phase; Humans; Luteinizing Hormone; Nitrates; Nitric Oxide Synthase; Nitrites; Ovulation Induction; Recombinant Proteins

2006
ADMA increases arterial stiffness and decreases cerebral blood flow in humans.
    Stroke, 2006, Volume: 37, Issue:8

    Topics: Adult; Arginine; Cerebral Arteries; Cerebrovascular Circulation; Compliance; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Humans; Injections, Intravenous; Magnetic Resonance Imaging; Male; Nitric Oxide Synthase; Reference Values; Vasomotor System

2006
Effects of combined supplementation with B vitamins and antioxidants on plasma levels of asymmetric dimethylarginine (ADMA) in subjects with elevated risk for cardiovascular disease.
    Atherosclerosis, 2007, Volume: 193, Issue:1

    Topics: Adult; Aged; Antioxidants; Arginine; Cardiovascular Diseases; Double-Blind Method; Female; Humans; Lipids; Male; Middle Aged; Risk Factors; Vitamin B Complex

2007
Daily consumption for six weeks of a lignan complex isolated from flaxseed does not affect endothelial function in healthy postmenopausal women.
    The Journal of nutrition, 2006, Volume: 136, Issue:9

    Topics: 4-Butyrolactone; Aged; Arginine; Blood Pressure; Body Weight; Cross-Over Studies; Diet; Double-Blind Method; Endothelin-1; Endothelium, Vascular; Female; Flax; Humans; Lignans; Middle Aged; Nitrates; Nitrites; Nitroglycerin; Patient Compliance; Placebos; Postmenopause; Vasodilation

2006
Effect of iloprost on plasma asymmetric dimethylarginine and plasma and platelet serotonin in patients with peripheral arterial occlusive disease.
    Prostaglandins & other lipid mediators, 2006, Volume: 80, Issue:3-4

    Topics: Aged; Aged, 80 and over; Arginine; Arterial Occlusive Diseases; Blood Platelets; Blood Pressure; Diabetes Mellitus, Type 2; Drug Administration Schedule; Exercise Test; Female; Humans; Iloprost; Infusions, Intravenous; Male; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Serotonin; Treatment Outcome

2006
No benefit of hemodiafiltration over hemodialysis in lowering elevated levels of asymmetric dimethylarginine in ESRD patients.
    Blood purification, 2006, Volume: 24, Issue:5-6

    Topics: Adult; Aged; Arginine; beta 2-Microglobulin; Female; Hemodiafiltration; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase

2006
Effects of amlodipine and valsartan on oxidative stress and plasma methylarginines in end-stage renal disease patients on hemodialysis.
    Kidney international, 2006, Volume: 70, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Arginine; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Female; Humans; Hypertension, Renal; Kidney Failure, Chronic; Male; Methylation; Middle Aged; Oxidative Stress; Renal Dialysis; Tetrazoles; Valine; Valsartan

2006
Pioglitazone improves endothelial function in non-diabetic patients with coronary artery disease.
    Cardiology, 2007, Volume: 108, Issue:3

    Topics: Adult; Aged; Arginine; Blood Sedimentation; Brachial Artery; C-Reactive Protein; Cardiovascular Agents; Coronary Artery Disease; Endothelium, Vascular; Fibrinogen; Humans; Lipids; Male; Middle Aged; Pioglitazone; PPAR gamma; Prospective Studies; Thiazolidinediones

2007
Changes of plasma asymmetric dimethylarginine levels after coronary artery bypass grafting.
    Scandinavian cardiovascular journal : SCJ, 2006, Volume: 40, Issue:6

    Topics: Arginine; Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Disease; Female; Heart Arrest, Induced; Humans; Hyperoxia; Male; Middle Aged; Myocardium; Postoperative Period; Time Factors

2006
Effects of alpha-lipoic acid on the plasma levels of asymmetric dimethylarginine in diabetic end-stage renal disease patients on hemodialysis: a pilot study.
    American journal of nephrology, 2007, Volume: 27, Issue:1

    Topics: Adult; Antioxidants; Arginine; Biomarkers; C-Reactive Protein; Cholesterol; Chromatography, High Pressure Liquid; Diabetic Nephropathies; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Kidney Failure, Chronic; Lipoproteins, LDL; Male; Middle Aged; Nitric Oxide Synthase; Oxidation-Reduction; Pilot Projects; Renal Dialysis; Thioctic Acid; Treatment Outcome

2007
Beneficial metabolic effects of nateglinide versus acarbose in patients with newly-diagnosed type 2 diabetes.
    Acta pharmacologica Sinica, 2007, Volume: 28, Issue:4

    Topics: Acarbose; Arginine; Blood Glucose; Cross-Over Studies; Cyclohexanes; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin; Lipids; Male; Middle Aged; Nateglinide; Phenylalanine; Prospective Studies

2007
The administration of estrogens, combined with anti-androgens, has beneficial effects on the hormonal features and asymmetric dimethyl-arginine levels, in women with the polycystic ovary syndrome.
    Atherosclerosis, 2008, Volume: 196, Issue:2

    Topics: Adult; Androgen Antagonists; Arginine; Cyproterone Acetate; Desogestrel; Drug Therapy, Combination; Endothelin-1; Estradiol; Estrogens; Estrogens, Conjugated (USP); Ethinyl Estradiol; Female; Hormones; Humans; Insulin Resistance; Polycystic Ovary Syndrome

2008
Effects of a supplement containing isoflavones and Actaea racemosa L. on asymmetric dimethylarginine, lipids, and C-reactive protein in menopausal women.
    Fertility and sterility, 2007, Volume: 87, Issue:4

    Topics: Aged; Arginine; C-Reactive Protein; Cholesterol, LDL; Cimicifuga; Coronary Disease; Double-Blind Method; Female; Humans; Isoflavones; Lipids; Menopause; Sample Size

2007
Asymmetric dimethylarginine determines the improvement of endothelium-dependent vasodilation by simvastatin: Effect of combination with oral L-arginine.
    Journal of the American College of Cardiology, 2007, Jun-12, Volume: 49, Issue:23

    Topics: Aged; Aged, 80 and over; Arginine; C-Reactive Protein; Drug Therapy, Combination; Endothelium, Vascular; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins; Male; Middle Aged; Nitric Oxide Synthase Type III; Simvastatin; Vasodilation

2007
Improvement in central arterial pressure waveform during hemodialysis is related to a reduction in asymmetric dimethylarginine (ADMA) levels.
    Nephron. Clinical practice, 2007, Volume: 106, Issue:4

    Topics: Aged; Arginine; Blood Pressure; Female; Humans; Kidney Failure, Chronic; Male; Renal Dialysis

2007
Hyperbaric oxygen therapy mediates increased nitric oxide production associated with wound healing: a preliminary study.
    Advances in skin & wound care, 2007, Volume: 20, Issue:7

    Topics: Arginine; Chromatography, High Pressure Liquid; Chronic Disease; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Exudates and Transudates; Fasting; Female; Granulation Tissue; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Nitric Oxide; Oxidation-Reduction; Time Factors; Treatment Outcome; Wound Healing; Wounds and Injuries

2007
Plasma dimethylarginine levels in chronic hemodialysis patients are independent of the type of dialyzer applied.
    Blood purification, 2007, Volume: 25, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Arginine; beta 2-Microglobulin; Biocompatible Materials; Complement C3a; Cross-Over Studies; Equipment Design; Female; Humans; Kidney Failure, Chronic; Male; Membranes, Artificial; Middle Aged; Nitric Oxide; Prospective Studies; Renal Dialysis

2007
Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.
    British journal of clinical pharmacology, 2008, Volume: 65, Issue:1

    Topics: Administration, Oral; Arginine; Citrulline; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Placebos; Vasodilation

2008
Improving proteinuria, endothelial functions and asymmetric dimethylarginine levels in chronic kidney disease: ramipril versus valsartan.
    Blood purification, 2007, Volume: 25, Issue:4

    Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Arginine; Biomarkers; Blood Glucose; C-Reactive Protein; Female; Glomerular Filtration Rate; Hemorheology; Humans; Insulin Resistance; Kidney Failure, Chronic; Lipids; Male; Middle Aged; Proteinuria; Ramipril; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan; Vasodilation

2007
Obstructive sleep apnea and endothelial function in school-aged nonobese children: effect of adenotonsillectomy.
    Circulation, 2007, Nov-13, Volume: 116, Issue:20

    Topics: Adenoidectomy; Arginine; Body Weight; CD40 Ligand; Child; Endothelium, Vascular; Female; Humans; Hyperemia; Hypoxia; Male; Nitric Oxide; Polysomnography; Sleep Apnea, Obstructive; Tonsillectomy; Tyrosine; Vasculitis

2007
Temporal effects of low-dose ACE inhibition on endothelial function in Type 1 diabetic patients.
    Journal of endocrinological investigation, 2007, Volume: 30, Issue:9

    Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Arginine; Diabetes Mellitus, Type 1; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Humans; Indoles; Male; Oxidative Stress; Thiobarbituric Acid Reactive Substances; Vasodilation

2007
Effect of telmisartan on forearm postischemic hyperemia and serum asymmetric dimethylarginine levels.
    American journal of hypertension, 2007, Volume: 20, Issue:12

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Arginine; Benzimidazoles; Benzoates; Blood Pressure; Endothelium, Vascular; Female; Forearm; Humans; Hyperemia; Hypertension; Male; Middle Aged; Telmisartan; Tetrazoles; Valine; Valsartan

2007
Rosiglitazone improves endothelial function and inflammation but not asymmetric dimethylarginine or oxidative stress in patients with type 2 diabetes mellitus.
    Vascular medicine (London, England), 2007, Volume: 12, Issue:4

    Topics: Adult; Aged; Arginine; Biomarkers; Blood Glucose; Blood Pressure; Brachial Artery; C-Reactive Protein; Carotid Arteries; Diabetes Mellitus; Double-Blind Method; Drug Therapy, Combination; Elasticity; Endothelium, Vascular; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Inflammation; Insulin; Male; Metformin; Middle Aged; Oxidative Stress; Rosiglitazone; Thiazolidinediones; Treatment Outcome; Vasodilation

2007
Effects of normalization of plasma testosterone levels in hypogonadal men on plasma levels and urinary excretion of asymmetric dimethylarginine (ADMA).
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2008, Volume: 40, Issue:1

    Topics: Adult; Aged; Arginine; Body Mass Index; Humans; Hypogonadism; Male; Middle Aged; Nitrates; Nitrites; Testosterone

2008
The effects of renal replacement therapy on plasma, asymmetric dimethylarginine, nitric oxide and C-reactive protein levels.
    Clinical and investigative medicine. Medecine clinique et experimentale, 2008, Volume: 31, Issue:1

    Topics: Adult; Arginine; Atherosclerosis; C-Reactive Protein; Endothelium, Vascular; Female; Humans; Inflammation; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Peritoneal Dialysis, Continuous Ambulatory; Risk Factors; Time Factors

2008
Metformin, arterial function, intima-media thickness and nitroxidation in metabolic syndrome: the mefisto study.
    Clinical and experimental pharmacology & physiology, 2008, Volume: 35, Issue:8

    Topics: Adult; Arginine; Carotid Arteries; Female; Humans; Hypoglycemic Agents; Male; Metabolic Syndrome; Metformin; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Tunica Intima

2008
Asymmetric dimethylarginine and the effect of folate substitution in children with familial hypercholesterolemia and diabetes mellitus type 1.
    Physiological research, 2009, Volume: 58, Issue:2

    Topics: Adolescent; Anticholesteremic Agents; Arginine; Azetidines; Biomarkers; Child; Diabetes Mellitus, Type 1; Drug Therapy, Combination; Endothelium, Vascular; Ezetimibe; Female; Folic Acid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Lipoproteins, LDL; Male; Risk Factors; Ultrasonography; Vitamin B Complex

2009
Acute effects of passive smoking on peripheral vascular function.
    Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:6

    Topics: Acute Disease; Administration, Sublingual; Adult; Aorta; Arginine; Blood Pressure; Carboxyhemoglobin; Cross-Over Studies; Endothelium, Vascular; Environmental Exposure; Heart Rate; Humans; Male; Nicotine; Nicotinic Agonists; Nitric Oxide; Nitric Oxide Synthase; Regional Blood Flow; Skin; Tobacco Smoke Pollution

2008
Effect of atorvastatin on plasma levels of asymmetric dimethylarginine in patients with non-ischaemic heart failure.
    European journal of heart failure, 2008, Volume: 10, Issue:5

    Topics: Arginine; Atorvastatin; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Heart Failure; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pyrroles; Ventricular Dysfunction, Left

2008
Antiproteinuric effects of angiotensin receptor blockers: telmisartan versus valsartan in hypertensive patients with type 2 diabetes mellitus and overt nephropathy.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:10

    Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Arginine; Benzimidazoles; Benzoates; Blood Pressure; C-Reactive Protein; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dinoprost; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Prospective Studies; Proteinuria; Renin-Angiotensin System; Telmisartan; Tetrazoles; Valine; Valsartan

2008
Short term fluvastatin treatment lowers serum asymmetric dimethylarginine levels in patients with metabolic syndrome.
    International heart journal, 2008, Volume: 49, Issue:3

    Topics: Adult; Arginine; Cholesterol; Endothelium, Vascular; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Male; Metabolic Syndrome; Middle Aged; Treatment Outcome

2008
Asymmetric dimethylarginine concentration and early recurrence of atrial fibrillation after electrical cardioversion.
    Pacing and clinical electrophysiology : PACE, 2008, Volume: 31, Issue:8

    Topics: Aged; Arginine; Atrial Fibrillation; Biomarkers; Electric Countershock; Female; Humans; Male; Middle Aged; Prognosis; Reproducibility of Results; Secondary Prevention; Sensitivity and Specificity; Treatment Outcome

2008
Nebivolol treatment reduces serum levels of asymmetric dimethylarginine and improves endothelial dysfunction in essential hypertensive patients.
    American journal of hypertension, 2008, Volume: 21, Issue:11

    Topics: Adrenergic beta-Antagonists; Aged; Amidohydrolases; Antihypertensive Agents; Arginine; Atenolol; Benzopyrans; Double-Blind Method; Endothelium, Vascular; Ethanolamines; Female; Humans; Hypertension; Male; Middle Aged; Nebivolol; Nitric Oxide Synthase Type III; Vasodilation

2008
Randomized placebo-controlled trial assessing a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on plasma asymmetric dimethylarginine concentration in mild to moderate CKD.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2009, Volume: 53, Issue:1

    Topics: Adult; Aged; Anticholesteremic Agents; Arginine; Carotid Arteries; Chronic Disease; Creatinine; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Kidney Diseases; Lipoproteins, LDL; Male; Middle Aged; Pravastatin; Vitamin B 12; Vitamin B 6; Vitamin E

2009
Effect of nitrous oxide anesthesia on plasma homocysteine and endothelial function.
    Anesthesiology, 2008, Volume: 109, Issue:4

    Topics: Aged; Anesthetics, Inhalation; Arginine; Endothelium, Vascular; Female; Homocysteine; Humans; Male; Middle Aged; Nitrous Oxide; Oxidative Stress; Prospective Studies; Time Factors

2008
Reduction of plasma asymmetric dimethylarginine in obese patients with chronic kidney disease after three years of a low-protein diet supplemented with keto-amino acids: a randomized controlled trial.
    Wiener klinische Wochenschrift, 2008, Volume: 120, Issue:15-16

    Topics: Adult; Aged; Amino Acids; Arginine; Combined Modality Therapy; Diet, Protein-Restricted; Dietary Supplements; Female; Humans; Keto Acids; Kidney Failure, Chronic; Male; Middle Aged; Obesity; Treatment Outcome; Young Adult

2008
Effects of growth hormone treatment on arginine to asymmetric dimethylarginine ratio and endothelial function in patients with growth hormone deficiency.
    Metabolism: clinical and experimental, 2008, Volume: 57, Issue:12

    Topics: Adiposity; Adolescent; Adult; Arginine; Body Weight; Endothelium, Vascular; Female; Growth Disorders; Hormone Replacement Therapy; Human Growth Hormone; Humans; Insulin-Like Growth Factor I; Lipids; Male; Middle Aged; Waist Circumference; Young Adult

2008
Endothelial function and insulin resistance in polycystic ovary syndrome: the effects of medical therapy.
    Fertility and sterility, 2010, Volume: 93, Issue:1

    Topics: Adult; Arginine; Biomarkers; Blood Glucose; C-Reactive Protein; Contraceptives, Oral, Combined; Contraceptives, Oral, Hormonal; Cyproterone Acetate; Drug Therapy, Combination; Endothelium, Vascular; Ethinyl Estradiol; Female; Humans; Hyperandrogenism; Hypoglycemic Agents; Inflammation Mediators; Insulin; Insulin Resistance; Lipids; Metformin; Plasminogen Activator Inhibitor 1; Polycystic Ovary Syndrome; Sex Hormone-Binding Globulin; Testosterone; Time Factors; Treatment Outcome; Vasodilation; von Willebrand Factor

2010
Study of the correlation between clinical efficiency of impaza and serum ADMA level.
    Bulletin of experimental biology and medicine, 2008, Volume: 145, Issue:3

    Topics: Adult; Antibodies; Arginine; Double-Blind Method; Erectile Dysfunction; Humans; Male; Nitric Oxide Synthase Type III

2008
Endothelial dysfunction, ADMA and insulin resistance in essential hypertension.
    International journal of cardiology, 2010, Jul-23, Volume: 142, Issue:3

    Topics: Acetylcholine; Adult; Arginine; Case-Control Studies; Endothelium, Vascular; Female; Homeostasis; Humans; Hypertension; Insulin Resistance; Male; Middle Aged; Nitric Oxide Synthase Type III; Nitroprusside; Regional Blood Flow; Risk Factors; Vasodilator Agents

2010
The effects of G-CSF-induced mobilization of progenitor cells are limited by ADMA.
    International journal of cardiology, 2010, Sep-03, Volume: 143, Issue:3

    Topics: Aged; Aged, 80 and over; Angina Pectoris; Antioxidants; Arginine; Cells, Cultured; Chromans; Coronary Disease; Endothelial Cells; Female; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Humans; Leukocytosis; Male; Middle Aged; Oxidative Stress; Peroxidase; Umbilical Veins

2010
Ranolazine improves endothelial function in patients with stable coronary artery disease.
    Coronary artery disease, 2009, Volume: 20, Issue:5

    Topics: Acetanilides; Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Agents; Coronary Artery Disease; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Humans; Hyperemia; Inflammation Mediators; Male; Manometry; Middle Aged; Piperazines; Ranolazine; Time Factors; Treatment Outcome; Vasodilation

2009
The effect of rosiglitazone on asymmetric dimethylarginine (ADMA) in critically ill patients.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Aged; Arginine; Critical Illness; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pilot Projects; Rosiglitazone; Thiazolidinediones

2009
Co-administration of ezetimibe enhances proteinuria-lowering effects of pitavastatin in chronic kidney disease patients partly via a cholesterol-independent manner.
    Pharmacological research, 2010, Volume: 61, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Anticholesteremic Agents; Arginine; Azetidines; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Deoxyguanosine; Drug Therapy, Combination; Dyslipidemias; Ezetimibe; Fatty Acid-Binding Proteins; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Diseases; Male; Middle Aged; Proteinuria; Quinolines; Severity of Illness Index; Treatment Outcome; Triglycerides

2010
Acute effects of 5-methyltetrahydrofolate on endothelial function and asymmetric dimethylarginine in patients with chronic heart failure.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2010, Volume: 20, Issue:5

    Topics: Aged; Arginine; Chronic Disease; Endothelium, Vascular; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Tetrahydrofolates

2010
Postprandial vascular effects of VIAject compared with insulin lispro and regular human insulin in patients with type 2 diabetes.
    Diabetes care, 2010, Volume: 33, Issue:1

    Topics: Arginine; Blood Glucose; Blood Vessels; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Injections, Subcutaneous; Insulin; Insulin Lispro; Male; Microcirculation; Middle Aged; Postprandial Period; Tyrosine

2010
Effects of an exercise intervention using Dance Dance Revolution on endothelial function and other risk factors in overweight children.
    International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity, 2009, Volume: 4, Issue:4

    Topics: Arginine; Biomarkers; Blood Glucose; Blood Pressure; Body Height; Body Mass Index; Body Weight; Brachial Artery; Child; Dance Therapy; Endothelium, Vascular; Exercise Therapy; Female; Humans; Inflammation Mediators; Insulin; Lipids; Male; Nitrates; Nitrites; Overweight; Oxygen Consumption; Patient Compliance; Physical Fitness; Risk Factors; Time Factors; Treatment Outcome; Ultrasonography; Vasodilation; Video Games

2009
Treatment with alpha-lipoic acid reduces asymmetric dimethylarginine in patients with type 2 diabetes mellitus.
    Translational research : the journal of laboratory and clinical medicine, 2010, Volume: 155, Issue:1

    Topics: Arginine; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Male; Middle Aged; Thioctic Acid

2010
Effect of genistein therapy on plasma levels of asymmetric dimethylarginine in healthy postmenopausal women: a randomized, placebo-controlled study.
    Fertility and sterility, 2010, Volume: 94, Issue:2

    Topics: Adult; Arginine; Atherosclerosis; Female; Genistein; Humans; Middle Aged; Phytoestrogens; Placebos; Postmenopause; Reference Values; Risk Factors

2010
Prophylactics of erectile dysfunction in patients with metabolic syndrome.
    Bulletin of experimental biology and medicine, 2009, Volume: 148, Issue:2

    Topics: Adult; Aged; Antibodies; Antihypertensive Agents; Arginine; Erectile Dysfunction; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Male; Metabolic Syndrome; Middle Aged

2009
Postprandial hyperglycemia is a determinant of platelet activation in early type 2 diabetes mellitus.
    Journal of thrombosis and haemostasis : JTH, 2010, Volume: 8, Issue:4

    Topics: Acarbose; Aged; Arginine; Biomarkers; Blood Glucose; C-Reactive Protein; CD40 Ligand; Diabetes Mellitus, Type 2; Dinoprost; Double-Blind Method; Enzyme Inhibitors; Female; Glycated Hemoglobin; Glycoside Hydrolase Inhibitors; Humans; Hyperglycemia; Hypoglycemic Agents; Italy; Lipid Peroxidation; Male; Middle Aged; P-Selectin; Platelet Activation; Postprandial Period; Thromboxane B2; Time Factors; Treatment Outcome

2010
Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailability.
    Arteriosclerosis, thrombosis, and vascular biology, 2010, Volume: 30, Issue:4

    Topics: AC133 Antigen; Adult; Alcoholic Beverages; Antigens, CD; Antigens, CD34; Arginine; Beer; Biological Availability; Biomarkers; Cell Adhesion; Cell Movement; Cell Proliferation; Cells, Cultured; Cellular Senescence; Endothelial Cells; Enzyme Inhibitors; Ethanol; Female; Flow Cytometry; Glycoproteins; Humans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Peptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Prospective Studies; Proto-Oncogene Proteins c-akt; Resveratrol; Stem Cells; Stilbenes; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor Receptor-2; Vasodilation; Wine

2010
Green tea catechins improve human forearm endothelial dysfunction and have antiatherosclerotic effects in smokers.
    Circulation journal : official journal of the Japanese Circulation Society, 2010, Volume: 74, Issue:3

    Topics: Acetylcholine; Adult; Arginine; Atherosclerosis; C-Reactive Protein; Catechin; CD40 Ligand; Chemokine CCL2; Endothelium, Vascular; Forearm; Humans; Male; Malondialdehyde; Nitroprusside; Oxidative Stress; Plant Extracts; Smoking; Tea; Vasodilation; Vasodilator Agents

2010
Robotic treadmill training improves cardiovascular function in spinal cord injury patients.
    International journal of cardiology, 2011, Jun-16, Volume: 149, Issue:3

    Topics: Adult; Aged; Arginine; Cardiovascular Physiological Phenomena; Coronary Circulation; Diastole; Echocardiography; Endothelium, Vascular; Exercise Therapy; Female; Humans; Male; Middle Aged; Physical Fitness; Robotics; Spinal Cord Injuries; Ventricular Function, Left

2011
Effect of moderate and high-dose simvastatin on asymmetric dimethylarginine-homocysteine metabolic pathways in patients with newly detected severe hypercholesterolemia.
    Cardiovascular therapeutics, 2011, Volume: 29, Issue:5

    Topics: Adult; Arginine; Biomarkers; Bulgaria; Cholesterol, LDL; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Prospective Studies; Severity of Illness Index; Simvastatin; Time Factors; Treatment Outcome

2011
Effect of supplementation with B vitamins and antioxidants on levels of asymmetric dimethylarginine (ADMA) and C-reactive protein (CRP): a double-blind, randomised, factorial design, placebo-controlled trial.
    European journal of nutrition, 2010, Volume: 49, Issue:8

    Topics: Adult; Antioxidants; Arginine; Ascorbic Acid; beta Carotene; Biomarkers; Blood Pressure; C-Reactive Protein; Cardiovascular Diseases; Cholesterol; Dietary Supplements; Double-Blind Method; Homocysteine; Humans; Male; Middle Aged; Protective Agents; Triglycerides; Vitamin B Complex; Vitamin E

2010
Randomized controlled trial of the effect of short-term coadministration of methylcobalamin and folate on serum ADMA concentration in patients receiving long-term hemodialysis.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2010, Volume: 55, Issue:6

    Topics: Administration, Oral; Aged; Arginine; Cardiovascular Diseases; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Injections, Intravenous; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Risk Factors; Vitamin B 12; Vitamin B Complex

2010
Asymmetric dimethylarginine correlates with measures of disease severity, major adverse cardiovascular events and all-cause mortality in patients with peripheral arterial disease.
    Vascular medicine (London, England), 2010, Volume: 15, Issue:4

    Topics: Aged; Aged, 80 and over; Ankle Brachial Index; Arginine; Blood Glucose; Creatinine; Exercise Test; Female; Follow-Up Studies; Humans; Insulin; Lipids; Male; Middle Aged; Peripheral Arterial Disease; Risk Factors; Severity of Illness Index

2010
N-3 polyunsaturated fatty acids early supplementation improves ultrasound indices of endothelial function, but not through NO inhibitors in patients with acute myocardial infarction: N-3 PUFA supplementation in acute myocardial infarction.
    Clinical nutrition (Edinburgh, Scotland), 2011, Volume: 30, Issue:1

    Topics: Aged; Angioplasty, Balloon, Coronary; Arginine; Blood Flow Velocity; Dietary Supplements; Dilatation, Pathologic; Endothelium, Vascular; Fatty Acids, Omega-3; Female; Humans; Linear Models; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Prospective Studies; Treatment Outcome; Ultrasonography

2011
The differences of asymmetric dimethylarginine removal by different dialysis treatments.
    Renal failure, 2010, Volume: 32, Issue:8

    Topics: Adult; Age Factors; Aged; Arginine; Dialysis Solutions; Female; Glomerular Filtration Rate; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Risk Factors

2010
Simvastatin and asymmetric dimethylarginine-homocysteine metabolic pathways in patients with newly detected severe hypercholesterolemia.
    Clinical laboratory, 2010, Volume: 56, Issue:7-8

    Topics: Adult; Anticholesteremic Agents; Arginine; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Homocysteine; Humans; Hypercholesterolemia; Lipids; Male; Simvastatin; Treatment Outcome

2010
Symmetrical and asymmetrical dimethylarginine as predictors for mortality in patients referred for coronary angiography: the Ludwigshafen Risk and Cardiovascular Health study.
    Clinical chemistry, 2011, Volume: 57, Issue:1

    Topics: Aged; Arginine; Biomarkers; Cardiovascular Diseases; Coronary Angiography; Coronary Disease; Female; Humans; Linear Models; Male; Middle Aged; Mortality; Predictive Value of Tests; Prognosis; Renal Insufficiency; Risk Factors

2011
Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men.
    International journal of cardiology, 2012, Mar-08, Volume: 155, Issue:2

    Topics: Ankle Brachial Index; Arginine; Blood Pressure; Citrulline; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type III; Placebos; Pulsatile Flow; Vascular Stiffness

2012
Statin treatment decreased serum asymmetric dimethylarginine (ADMA) levels in ischemic stroke patients.
    Journal of atherosclerosis and thrombosis, 2011, Volume: 18, Issue:2

    Topics: Aged; Aged, 80 and over; Arginine; Atherosclerosis; Atorvastatin; Brain Ischemia; Cholesterol, LDL; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Linear Models; Male; Middle Aged; Pravastatin; Prospective Studies; Pyrroles; Quinolines; Stroke

2011
Inflammatory-metabolic parameters in obese and nonobese normoandrogenemic polycystic ovary syndrome during metformin and oral contraceptive treatment.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2011, Volume: 27, Issue:9

    Topics: Adult; Arginine; Body Mass Index; Cardiovascular Diseases; Contraceptives, Oral; Female; Homocysteine; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Obesity; Polycystic Ovary Syndrome; Prospective Studies; Risk Factors; Young Adult

2011
Transient endothelial dysfunction following flow-mediated dilation assessment.
    Heart and vessels, 2011, Volume: 26, Issue:5

    Topics: Adult; Arginine; Biomarkers; Brachial Artery; Endothelium, Vascular; Female; Humans; Hyperemia; Infusions, Intravenous; Italy; Male; Time Factors; Ultrasonography, Doppler; Vasodilation; Young Adult

2011
Helicobacter pylori eradication lowers serum asymmetric dimethylarginine levels.
    Mediators of inflammation, 2010, Volume: 2010

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Amoxicillin; Anti-Bacterial Agents; Arginine; Atherosclerosis; Cardiovascular Abnormalities; Clarithromycin; Enzyme Inhibitors; Female; Helicobacter Infections; Helicobacter pylori; Humans; Lansoprazole; Male; Middle Aged; Nitric Oxide Synthase Type III; Young Adult

2010
Weight loss improves endothelial function independently of ADMA reduction in severe obesity.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2011, Volume: 43, Issue:5

    Topics: Adolescent; Adult; Aged; Arginine; Body Mass Index; Caloric Restriction; Cell Adhesion Molecules; Endothelial Cells; Female; Humans; Male; Middle Aged; Obesity; Weight Loss; Young Adult

2011
Influence of dietary fat ingestion on asymmetrical dimethylarginine in lean and obese human subjects.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2012, Volume: 22, Issue:9

    Topics: Adult; Arginine; Chromatography, Gas; Cross-Over Studies; Diet; Dietary Fats; Eating; Energy Intake; Female; Humans; Male; Meals; Nitrates; Nitrites; Obesity; Tandem Mass Spectrometry

2012
Effects of walking on heart rate recovery, endothelium modulators and quality of life in patients with heart failure.
    European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 2011, Volume: 18, Issue:4

    Topics: Aged; Analysis of Variance; Arginine; Biomarkers; Chronic Disease; Endothelium, Vascular; Exercise Therapy; Female; Greece; Heart Failure; Heart Rate; Homocysteine; Humans; Inflammation Mediators; Male; Middle Aged; Oxidative Stress; Quality of Life; Recovery of Function; Surveys and Questionnaires; Time Factors; Treatment Outcome; Walking

2011
Exercise training increases endothelial progenitor cells and decreases asymmetric dimethylarginine in peripheral arterial disease: a randomized controlled trial.
    Atherosclerosis, 2011, Volume: 217, Issue:1

    Topics: Aged; Arginine; Cell Movement; Chemokine CXCL12; Endothelial Cells; Exercise; Female; Flow Cytometry; Humans; Intermittent Claudication; Male; Middle Aged; Neovascularization, Pathologic; Peripheral Arterial Disease; Stem Cells; Time Factors; Vascular Endothelial Growth Factor A

2011
Serum retinol-binding protein 4, leptin, and plasma asymmetric dimethylarginine levels in obese and nonobese young women with polycystic ovary syndrome.
    Fertility and sterility, 2011, Volume: 96, Issue:1

    Topics: Adult; Arginine; Biomarkers; Female; Humans; Leptin; Obesity; Polycystic Ovary Syndrome; Prospective Studies; Retinol-Binding Proteins, Plasma; Young Adult

2011
The impact of pioglitazone on ADMA and oxidative stress markers in patients with type 2 diabetes.
    Primary care diabetes, 2012, Volume: 6, Issue:2

    Topics: Academic Medical Centers; Arginine; Biomarkers; Cross-Over Studies; Diabetes Mellitus, Type 2; Dinoprost; F2-Isoprostanes; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Nitrates; Nitrites; Oxidative Stress; Pioglitazone; Prospective Studies; South Carolina; Thiazolidinediones; Time Factors; Treatment Outcome

2012
Salt sensitivity in blacks: evidence that the initial pressor effect of NaCl involves inhibition of vasodilatation by asymmetrical dimethylarginine.
    Hypertension (Dallas, Tex. : 1979), 2011, Volume: 58, Issue:3

    Topics: Adult; Arginine; Black or African American; Blood Pressure; Dose-Response Relationship, Drug; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Sodium Chloride, Dietary; Time Factors; Vascular Resistance; Vasodilation

2011
Effects of 7 days of arginine-alpha-ketoglutarate supplementation on blood flow, plasma L-arginine, nitric oxide metabolites, and asymmetric dimethyl arginine after resistance exercise.
    International journal of sport nutrition and exercise metabolism, 2011, Volume: 21, Issue:4

    Topics: Adolescent; Adult; Arginine; Blood Pressure; Dietary Supplements; Double-Blind Method; Heart Rate; Hemodynamics; Humans; Ketoglutaric Acids; Male; Nitrates; Nitric Oxide; Nitrites; Resistance Training; Young Adult

2011
Renovascular protective effects of erythropoietin in patients with chronic kidney disease.
    Internal medicine (Tokyo, Japan), 2011, Volume: 50, Issue:18

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acute Kidney Injury; Aged; Arginine; Atherosclerosis; Biomarkers; Cardiovascular System; Carotid Intima-Media Thickness; Deoxyguanosine; Dose-Response Relationship, Drug; Erythropoietin; Fatty Acid-Binding Proteins; Female; Glomerular Filtration Rate; Hemoglobins; Humans; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Natriuretic Peptide, Brain; Oxidative Stress; Prospective Studies; Recombinant Proteins; Treatment Outcome

2011
Postprandial hyperglycemia impairs vascular endothelial function in healthy men by inducing lipid peroxidation and increasing asymmetric dimethylarginine:arginine.
    The Journal of nutrition, 2011, Volume: 141, Issue:11

    Topics: Adolescent; Adult; Area Under Curve; Arginine; Blood Glucose; Chromatography, High Pressure Liquid; Cross-Over Studies; Endothelium, Vascular; Homeostasis; Humans; Hyperglycemia; Insulin; Lipid Peroxidation; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Postprandial Period; Young Adult

2011
Addition of liraglutide in patients with Type 2 diabetes well controlled on metformin monotherapy improves several markers of vascular function.
    Diabetic medicine : a journal of the British Diabetic Association, 2012, Volume: 29, Issue:9

    Topics: Adult; Aged; Arginine; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; E-Selectin; Endothelium, Vascular; Female; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Liraglutide; Male; Metformin; Microcirculation; Middle Aged; Plasminogen Activator Inhibitor 1; Proinsulin; Prospective Studies

2012
Sesame oil consumption exerts a beneficial effect on endothelial function in hypertensive men.
    European journal of preventive cardiology, 2013, Volume: 20, Issue:2

    Topics: Adult; Analysis of Variance; Arginine; Biomarkers; Blood Pressure; Brachial Artery; Diet; Endothelium, Vascular; Greece; Humans; Hypertension; Inflammation Mediators; Intercellular Adhesion Molecule-1; Male; Middle Aged; Postprandial Period; Sesame Oil; Time Factors; Treatment Outcome; Ultrasonography; Vasodilation

2013
Vascular effects of nebivolol added to hydrochlorothiazide in African Americans with hypertension and echocardiographic evidence of diastolic dysfunction: the NASAA study.
    Journal of cardiovascular pharmacology and therapeutics, 2012, Volume: 17, Issue:3

    Topics: Adult; Aged; Antihypertensive Agents; Arginine; Benzopyrans; Black or African American; Dose-Response Relationship, Drug; Drug Therapy, Combination; Echocardiography; Ethanolamines; Female; Heart Failure, Diastolic; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Nebivolol; Nitrates; Nitric Oxide; Nitrites

2012
Effect of nisoldipine and olmesartan on endothelium-dependent vasodilation in essential hypertensive patients.
    CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:5

    Topics: Aged; Anthracenes; Antihypertensive Agents; Arginine; Blood Pressure; C-Reactive Protein; Case-Control Studies; Endothelin-1; Endothelium; Female; Humans; Hypertension; Imidazoles; Male; Middle Aged; Nisoldipine; Nitric Oxide; Propane; Prostaglandins F; Single-Blind Method; Tetrazoles; Vasodilation

2012
The effect of diet and exercise on markers of endothelial function in overweight and obese women with polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2012, Volume: 27, Issue:7

    Topics: Adult; Arginine; Body Mass Index; Cardiovascular Diseases; Diet; Endothelium, Vascular; Exercise; Exercise Therapy; Female; Humans; Insulin Resistance; Intercellular Adhesion Molecule-1; Overweight; Plasminogen Activator Inhibitor 1; Polycystic Ovary Syndrome; Risk; Vascular Cell Adhesion Molecule-1

2012
Ramipril sensitizes platelets to nitric oxide: implications for therapy in high-risk patients.
    Journal of the American College of Cardiology, 2012, Sep-04, Volume: 60, Issue:10

    Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Arginine; Biomarkers; Blood Platelets; Cohort Studies; Cyclic GMP; Double-Blind Method; Drug Administration Schedule; Female; Guanylate Cyclase; Humans; Male; Malondialdehyde; Middle Aged; Nitric Oxide; Nitroprusside; Oxidative Stress; Platelet Aggregation; Ramipril; Thrombospondin 1

2012
Probing the mechanisms of intradialytic hypertension: a pilot study targeting endothelial cell dysfunction.
    Clinical journal of the American Society of Nephrology : CJASN, 2012, Volume: 7, Issue:8

    Topics: AC133 Antigen; Adult; Aged; Aldehyde Dehydrogenase; Antigens, CD; Antigens, CD34; Antihypertensive Agents; Arginine; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Body Weight; Carbazoles; Carvedilol; Endothelin-1; Endothelium, Vascular; Female; Glycoproteins; Humans; Hypertension; Male; Middle Aged; Peptides; Pilot Projects; Propanolamines; Prospective Studies; Renal Dialysis; Stem Cells; Texas; Time Factors; Treatment Outcome; Vascular Stiffness; Vasodilation; Vasodilator Agents

2012
Supplementation of a γ-tocopherol-rich mixture of tocopherols in healthy men protects against vascular endothelial dysfunction induced by postprandial hyperglycemia.
    The Journal of nutritional biochemistry, 2013, Volume: 24, Issue:1

    Topics: Adolescent; Adult; Antioxidants; Arginine; Ascorbic Acid; Blood Glucose; Brachial Artery; Dietary Supplements; Endothelium, Vascular; gamma-Tocopherol; Humans; Hyperglycemia; Insulin; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Tocopherols; Uric Acid; Young Adult

2013
Feasibility of landiolol and bisoprolol for prevention of atrial fibrillation after coronary artery bypass grafting: a pilot study.
    The Journal of thoracic and cardiovascular surgery, 2012, Volume: 144, Issue:5

    Topics: Administration, Oral; Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Antioxidants; Arginine; Atrial Fibrillation; Biomarkers; Bisoprolol; C-Reactive Protein; Coronary Artery Bypass; Creatine Kinase, MB Form; Drug Administration Schedule; Fatty Acid Binding Protein 3; Fatty Acid-Binding Proteins; Female; Hemodynamics; Humans; Infusions, Intravenous; Japan; Male; Middle Aged; Morpholines; Natriuretic Peptide, Brain; Pilot Projects; Serum Amyloid P-Component; Single-Blind Method; Time Factors; Treatment Outcome; Troponin I; Urea

2012
Blood pressure and plasma renin activity responses to different strategies to inhibit the renin-angiotensin-aldosterone system during exercise.
    Journal of the renin-angiotensin-aldosterone system : JRAAS, 2013, Volume: 14, Issue:1

    Topics: Adult; Aged; Amides; Arginine; Blood Pressure; Demography; Endpoint Determination; Exercise; Female; Fumarates; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Renin; Renin-Angiotensin System; Systole; Tetrazoles; Valine; Valsartan

2013
Serum levels of asymmetric dimethylarginine and apelin as potential markers of vascular endothelial dysfunction in early rheumatoid arthritis.
    Mediators of inflammation, 2012, Volume: 2012

    Topics: Adult; Aged; Antirheumatic Agents; Apelin; Arginine; Arthritis, Rheumatoid; Endothelium, Vascular; Female; Humans; Intercellular Signaling Peptides and Proteins; Male; Middle Aged

2012
Improved blood pressure, nitric oxide and asymmetric dimethylarginine are independent after bariatric surgery.
    Annals of clinical biochemistry, 2012, Volume: 49, Issue:Pt 6

    Topics: Arginine; Bariatric Surgery; Blood Pressure; Female; Humans; Male; Nitric Oxide; Obesity, Morbid; Weight Loss

2012
[Regular exercise training decreases asymmetric dimethylarginine after kidney transplantation].
    Vnitrni lekarstvi, 2012, Volume: 58, Issue:9

    Topics: Adiponectin; Adult; Aged; Arginine; C-Reactive Protein; Exercise Therapy; Female; Humans; Kidney Transplantation; Male; Middle Aged; Nitric Oxide Synthase; Tumor Necrosis Factor-alpha

2012
Oral L-arginine supplementation in patients with mild arterial hypertension and its effect on plasma level of asymmetric dimethylarginine, L-citruline, L-arginine and antioxidant status.
    European review for medical and pharmacological sciences, 2012, Volume: 16, Issue:12

    Topics: Administration, Oral; Adult; Antioxidants; Arginine; Blood Pressure Monitoring, Ambulatory; Citrulline; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypertension; Male

2012
The biological evaluation of ADMA/SDMA and eNOS in patients with ACHF.
    Frontiers in bioscience (Elite edition), 2013, 01-01, Volume: 5, Issue:2

    Topics: Adult; Aged; Alanine Transaminase; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Arginine; Aspartate Aminotransferases; Blotting, Western; Chromatography, High Pressure Liquid; Digoxin; Diuretics; Echocardiography; Electron Transport Complex IV; Female; Heart Failure; Humans; Kidney Function Tests; Leukocytes, Mononuclear; Male; Middle Aged; Nitric Oxide Synthase Type III; Oxygen

2013
Organic nitrates favor regression of left ventricular hypertrophy in hypertensive patients on chronic peritoneal dialysis.
    International journal of molecular sciences, 2013, Jan-07, Volume: 14, Issue:1

    Topics: Adult; Aged; Antihypertensive Agents; Arginine; Blood Pressure; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Isosorbide Dinitrate; Kidney Failure, Chronic; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Prospective Studies; Time Factors; Treatment Outcome; Vasodilator Agents

2013
[Impact of adding folic acid, vitamin B(12) and probucol to standard antihypertensive medication on plasma homocysteine and asymmetric dimethylarginine levels of essential hypertension patients].
    Zhonghua xin xue guan bing za zhi, 2012, Volume: 40, Issue:12

    Topics: Aged; Antihypertensive Agents; Arginine; Female; Folic Acid; Homocysteine; Humans; Hypertension; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type III; Plasma; Probucol; Vitamin B 12; Vitamin B Complex; Vitamins

2012
Hypothermia decreases cerebrospinal fluid asymmetric dimethylarginine levels in children with traumatic brain injury.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2013, Volume: 14, Issue:4

    Topics: Adolescent; Arginine; Brain Injuries; Case-Control Studies; Cerebrospinal Fluid; Child; Child, Preschool; Chromatography, Liquid; Female; Humans; Hypothermia, Induced; Infant; Male; Nitrates; Nitrites; Tandem Mass Spectrometry

2013
Aspirin increases nitric oxide formation in chronic stable coronary disease.
    Journal of cardiovascular pharmacology and therapeutics, 2013, Volume: 18, Issue:3

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Aspirin; Biomarkers; Cardiovascular Agents; Coronary Disease; Dose-Response Relationship, Drug; Double-Blind Method; Down-Regulation; Female; Heme Oxygenase-1; Humans; Male; Middle Aged; Nitric Oxide; Platelet Aggregation Inhibitors; Tablets, Enteric-Coated; Up-Regulation

2013
The association between progression of atherosclerosis and the methylated amino acids asymmetric dimethylarginine and trimethyllysine.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Adenosine; Aged; Arginine; Coronary Angiography; Coronary Artery Disease; Disease Progression; Ethionine; Female; Folic Acid; Follow-Up Studies; Humans; Lysine; Male; Methylation; Middle Aged; Treatment Outcome; Vitamin B 12; Vitamin B 6; Vitamin B Complex

2013
Pioglitazone decreases asymmetric dimethylarginine levels in patients with impaired glucose tolerance or type 2 diabetes.
    Rejuvenation research, 2013, Volume: 16, Issue:5

    Topics: Aged; Aged, 80 and over; Arginine; Diabetes Mellitus, Type 2; Female; Fibronectins; Glucose Intolerance; Humans; Male; Middle Aged; Pioglitazone; Regression Analysis; Sulfonylurea Compounds; Thiazolidinediones

2013
Asymmetric dimethylarginine in response to recombinant tissue-type plasminogen activator and erythropoietin in acute stroke.
    Stroke, 2013, Volume: 44, Issue:8

    Topics: Acute Disease; Aged; Aged, 80 and over; Arginine; Double-Blind Method; Drug Therapy, Combination; Erythropoietin; Female; Humans; Male; Middle Aged; Severity of Illness Index; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome

2013
Lifestyle modification decreases arterial stiffness and plasma asymmetric dimethylarginine level in overweight and obese men.
    Coronary artery disease, 2013, Volume: 24, Issue:7

    Topics: Adult; Animals; Ankle Brachial Index; Arginine; Biomarkers; Caloric Restriction; Cardiovascular Diseases; Down-Regulation; Exercise; Humans; Male; Middle Aged; Obesity; Overweight; Pulse Wave Analysis; Risk Reduction Behavior; Time Factors; Treatment Outcome; Vascular Stiffness

2013
Serum uric acid levels and endothelial dysfunction in patients with autosomal dominant polycystic kidney disease.
    Nephron. Clinical practice, 2013, Volume: 123, Issue:3-4

    Topics: Adult; Arginine; C-Reactive Protein; Cross-Sectional Studies; Endothelium, Vascular; Glomerular Filtration Rate; Humans; Middle Aged; Multivariate Analysis; Polycystic Kidney, Autosomal Dominant; Uric Acid; Vasodilation

2013
Low-fat milk ingestion prevents postprandial hyperglycemia-mediated impairments in vascular endothelial function in obese individuals with metabolic syndrome.
    The Journal of nutrition, 2013, Volume: 143, Issue:10

    Topics: Adult; Animals; Area Under Curve; Arginine; Blood Glucose; Brachial Artery; Cross-Over Studies; Diet; Dietary Fats; Double-Blind Method; Endothelium, Vascular; Fasting; Female; Humans; Hyperglycemia; Lipid Peroxidation; Male; Malondialdehyde; Metabolic Syndrome; Milk; Nitric Oxide; Obesity; Oryza; Oxidative Stress; Plant Preparations; Postprandial Period; Vascular Diseases; Vasodilation

2013
Disparate effects of anti-TNF-α therapies on measures of disease activity and mediators of endothelial damage in ankylosing spondylitis.
    Pharmacological reports : PR, 2013, Volume: 65, Issue:4

    Topics: Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arginine; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Etanercept; Female; Humans; Immunoglobulin G; Male; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha

2013
Comparision of effects of rosuvastatin versus atorvastatin treatment on plasma levels of asymmetric dimethylarginine in patients with hyperlipidemia having coronary artery disease.
    Angiology, 2014, Volume: 65, Issue:9

    Topics: Arginine; Atorvastatin; Biomarkers; Coronary Angiography; Coronary Stenosis; Down-Regulation; Female; Fluorobenzenes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Lipids; Male; Middle Aged; Prospective Studies; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Severity of Illness Index; Sulfonamides; Time Factors; Treatment Outcome; Turkey

2014
Aerobic exercise training decreases plasma asymmetric dimethylarginine concentrations with increase in arterial compliance in postmenopausal women.
    American journal of hypertension, 2014, Volume: 27, Issue:3

    Topics: Aged; Arginine; Biomarkers; Carotid Arteries; Carotid Intima-Media Thickness; Compliance; Down-Regulation; Exercise; Female; Heart Rate; Humans; Japan; Middle Aged; Postmenopause; Time Factors; Vascular Stiffness

2014
Effect of vildagliptin add-on treatment to metformin on plasma asymmetric dimethylarginine in type 2 diabetes mellitus patients.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Adamantane; Adult; Aged; Arginine; C-Reactive Protein; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Combinations; Female; Fibrinogen; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Nitric Oxide; Nitriles; Pyrrolidines; Vildagliptin

2014
Nutrition before, during, and after surgery increases the arginine:asymmetric dimethylarginine ratio and relates to improved myocardial glucose metabolism: a randomized controlled trial.
    The American journal of clinical nutrition, 2014, Volume: 99, Issue:6

    Topics: Aged; Algorithms; Arginine; Coronary Artery Bypass, Off-Pump; Enteral Nutrition; Fluorodeoxyglucose F18; Glucose; Heart; Humans; Male; Middle Aged; Myocardium; Netherlands; Nutritional Status; Parenteral Nutrition; Perioperative Care; Positron-Emission Tomography; Postoperative Care; Postoperative Complications; Preoperative Care; Risk

2014
Supplementation of folic acid and vitamin B₁₂ reduces plasma levels of asymmetric dimethylarginine in patients with acute ischemic stroke.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2014, Volume: 21, Issue:9

    Topics: Aged; Arginine; Blood Chemical Analysis; Brain Ischemia; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Stroke; Time Factors; Treatment Outcome; Vitamin B 12

2014
Effect of high potassium diet on endothelial function.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2014, Volume: 24, Issue:9

    Topics: Adolescent; Adult; Aged; Arginine; Blood Glucose; Blood Pressure; Body Mass Index; Cross-Over Studies; E-Selectin; Endothelin-1; Endothelium, Vascular; Female; Fruit; Healthy Volunteers; Humans; Intercellular Adhesion Molecule-1; Male; Middle Aged; Patient Compliance; Potassium, Dietary; Pulse Wave Analysis; Single-Blind Method; Urinalysis; Vegetables; Young Adult

2014
Asymmetric dimethylarginine and L-arginine levels in neonatal sepsis and septic shock.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2015, Volume: 28, Issue:8

    Topics: Arginine; Biomarkers; Case-Control Studies; Female; Humans; Infant, Newborn; Male; Multiple Organ Failure; Prognosis; Prospective Studies; Sepsis; Severity of Illness Index; Shock, Septic

2015
The importance of intraoperative selenium blood levels on organ dysfunction in patients undergoing off-pump cardiac surgery: a randomised controlled trial.
    PloS one, 2014, Volume: 9, Issue:8

    Topics: Aged; Arginine; Biomarkers; Coronary Artery Bypass, Off-Pump; Creatine Kinase, MB Form; Female; Glutathione Peroxidase; Humans; Interleukin-6; Male; Middle Aged; Oxidative Stress; Postoperative Complications; Postoperative Period; Predictive Value of Tests; Selenium

2014
Decreased levels of homoarginine and asymmetric dimethylarginine in children with type 1 diabetes: associations with cardiovascular risk factors but no effect by atorvastin.
    Journal of pediatric endocrinology & metabolism : JPEM, 2015, Volume: 28, Issue:1-2

    Topics: Adolescent; Anticholesteremic Agents; Arginine; Atorvastatin; Cardiovascular Diseases; Diabetes Mellitus, Type 1; Female; Follow-Up Studies; Glycated Hemoglobin; Heptanoic Acids; Homoarginine; Humans; Lipids; Male; Pilot Projects; Pyrroles; Risk Factors; Treatment Outcome

2015
Effects of an energy-restricted diet rich in plant-derived α-linolenic acid on systemic inflammation and endothelial function in overweight-to-obese patients with metabolic syndrome traits.
    The British journal of nutrition, 2014, Oct-28, Volume: 112, Issue:8

    Topics: Adipokines; Adult; alpha-Linolenic Acid; Arginine; Biomarkers; C-Reactive Protein; Chitinase-3-Like Protein 1; Diet, Reducing; Down-Regulation; E-Selectin; Endothelium, Vascular; Fatty Acids, Monounsaturated; Female; Humans; Inflammation Mediators; Intercellular Adhesion Molecule-1; Lectins; Male; Metabolic Syndrome; Middle Aged; Obesity; Overweight; Plant Oils; Rapeseed Oil; Vasculitis; Weight Loss

2014
Decrease of asymmetric dimethyl arginine after anti-TNF therapy in patients with rheumatoid arthritis.
    Drug development research, 2014, Volume: 75 Suppl 1

    Topics: Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arginine; Arthritis, Rheumatoid; Etanercept; Female; Humans; Immunoglobulin G; Male; Middle Aged; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha

2014
The impact of different supervised exercise regimens on endothelial function in patients with intermittent claudication.
    Vascular, 2015, Volume: 23, Issue:6

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Endothelium, Vascular; Exercise Test; Exercise Therapy; Exercise Tolerance; Female; Humans; Hyperemia; Intermittent Claudication; Male; Middle Aged; Nitric Oxide; Pain Measurement; Quality of Life; Resistance Training; South Australia; Surveys and Questionnaires; Time Factors; Treatment Outcome; Vasodilation; Walking

2015
Digital plethysmography and arginine metabolism in prehypertension: effect of nebivolol therapy.
    Journal of clinical hypertension (Greenwich, Conn.), 2015, Volume: 17, Issue:1

    Topics: Adult; Antihypertensive Agents; Arginine; Benzopyrans; Blood Pressure; Citrulline; Endothelium, Vascular; Ethanolamines; Female; Humans; Male; Middle Aged; Nebivolol; Nitric Oxide; Plethysmography; Prehypertension; Prospective Studies; Regional Blood Flow

2015
Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Aged; Arginine; Arthritis, Rheumatoid; Coronary Artery Disease; Female; Homoarginine; Homocysteine; Humans; Male; Middle Aged; Peripheral Arterial Disease

2015
[Salvia Miltiorrhiza reduces plasma levels of asymmetric ADMA in patients with non-ST elevation myocardial infarction undergoing percutaneous coronary intervention].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2014, Volume: 34, Issue:12

    Topics: Arginine; Drugs, Chinese Herbal; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Salvia miltiorrhiza

2014
Effects of dialysis solution on the cardiovascular function in peritoneal dialysis patients.
    Internal medicine (Tokyo, Japan), 2015, Volume: 54, Issue:1

    Topics: Adult; Aged; Arginine; Biomarkers; Blood Flow Velocity; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Carotid Artery Diseases; Carotid Intima-Media Thickness; Causality; Comorbidity; Dialysis Solutions; Echocardiography; Female; Humans; Hydrogen-Ion Concentration; Incidence; Male; Middle Aged; Peritoneal Dialysis; Prospective Studies; Renal Insufficiency

2015
Comparison of Before and After Varicocelectomy Levels of Trace Elements, Nitric Oxide, Asymmetric Dimethylarginine and Malondialdehyde in the Seminal Plasma and Peripheral and Spermatic Veins.
    Biological trace element research, 2015, Volume: 167, Issue:2

    Topics: Adult; Arginine; Humans; Male; Malondialdehyde; Nitric Oxide; Postoperative Period; Preoperative Period; Semen; Trace Elements; Varicocele

2015
Proton pump inhibitors and vascular function: A prospective cross-over pilot study.
    Vascular medicine (London, England), 2015, Volume: 20, Issue:4

    Topics: Administration, Oral; Adult; Arginine; Biomarkers; California; Coronary Disease; Cross-Over Studies; Drug Administration Schedule; Female; Humans; Lansoprazole; Male; Middle Aged; Pilot Projects; Predictive Value of Tests; Prospective Studies; Proton Pump Inhibitors; Reproducibility of Results; Risk Assessment; Time Factors; Upper Extremity; Vasodilation; Young Adult

2015
Differential associations of circulating asymmetric dimethylarginine and cell adhesion molecules with metformin use in patients with type 2 diabetes mellitus and stable coronary artery disease.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Aged; Aged, 80 and over; Arginine; Cell Adhesion Molecules; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; Male; Metformin; Middle Aged; Time Factors

2015
Asymmetric dimethylarginine (ADMA) in human blood: effects of extended haemodialysis in the critically ill patient with acute kidney injury, protein binding to human serum albumin and proteolysis by thermolysin.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Acute Kidney Injury; Arginine; Critical Illness; Female; Humans; Male; Protein Binding; Proteolysis; Renal Dialysis; Serum Albumin; Thermolysin

2015
Changes in plasma levels of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine after a single dose of vardenafil in patients with pulmonary hypertension.
    Vascular pharmacology, 2015, Volume: 73

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Arginine; Atrial Function, Right; Atrial Pressure; Biomarkers; Cardiac Output; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Phosphodiesterase 5 Inhibitors; Time Factors; Treatment Outcome; Vardenafil Dihydrochloride; Vasodilator Agents

2015
Impact of Indoxyl Sulfate, a Uremic Toxin, on Non-Culprit Coronary Plaque Composition Assessed on Integrated Backscatter Intravascular Ultrasound.
    Circulation journal : official journal of the Japanese Circulation Society, 2015, Volume: 79, Issue:8

    Topics: Aged; Arginine; Biomarkers; Coronary Artery Disease; Female; Humans; Indican; Male; Middle Aged; Plaque, Atherosclerotic; Risk Factors; Ultrasonography, Interventional

2015
Chronic heart failure and aging - effects of exercise training on endothelial function and mechanisms of endothelial regeneration: Results from the Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study.
    European journal of preventive cardiology, 2016, Volume: 23, Issue:4

    Topics: Aged; Aging; Arginine; Blood Flow Velocity; Cell Count; Chemokine CXCL12; Endothelial Progenitor Cells; Endothelium, Vascular; Exercise Therapy; Heart Failure; Humans; Intercellular Adhesion Molecule-1; Middle Aged; Prospective Studies; Radial Artery; Regeneration; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor A

2016
Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free L-arginine in humans.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Adolescent; Adult; Amidinotransferases; Amino Acid Metabolism, Inborn Errors; Animals; Arginine; Child; Coronary Artery Disease; Developmental Disabilities; Female; Guanidinoacetate N-Methyltransferase; Homoarginine; Humans; Intellectual Disability; Language Development Disorders; Male; Mice; Mice, Knockout; Middle Aged; Movement Disorders; Peripheral Arterial Disease; Speech Disorders

2015
Serum and cerebrospinal fluid concentrations of homoarginine, arginine, asymmetric and symmetric dimethylarginine, nitrite and nitrate in patients with multiple sclerosis and neuromyelitis optica.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Adult; Arginine; Female; Homoarginine; Humans; Male; Middle Aged; Multiple Sclerosis; Neuromyelitis Optica; Nitrates; Nitrites

2015
The L-arginine/NO pathway and homoarginine are altered in Duchenne muscular dystrophy and improved by glucocorticoids.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Adolescent; Adult; Arginine; Child; Child, Preschool; Cross-Sectional Studies; Glucocorticoids; Homoarginine; Humans; Infant; Male; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Nitric Oxide; Pilot Projects

2015
Plasma ADMA associates with all-cause mortality in renal transplant recipients.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Adult; Aged; Arginine; Disease-Free Survival; Endothelium, Vascular; Female; Follow-Up Studies; Graft Rejection; Humans; Kidney Transplantation; Male; Middle Aged; Models, Biological; Survival Rate

2015
Homocysteine and Arginine-to-Asymmetric Dimethylarginine Ratio Associated With Blood Pressure Abnormalities in Children With Early Chronic Kidney Disease.
    Circulation journal : official journal of the Japanese Circulation Society, 2015, Volume: 79, Issue:9

    Topics: Adolescent; Arginine; Blood Pressure; Child; Cross-Sectional Studies; Female; Homocysteine; Humans; Hypertension; Male; Renal Insufficiency, Chronic; Vascular Stiffness

2015
Homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in short stature children without and with growth hormone deficiency: hArg and ADMA are involved differently in growth in the childhood.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Adolescent; Adult; Arginine; Child; Female; Growth Disorders; Homoarginine; Human Growth Hormone; Humans; Insulin-Like Growth Factor I; Male

2015
Interrelationship of Multiple Endothelial Dysfunction Biomarkers with Chronic Kidney Disease.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: Adult; Aged; Albuminuria; Arginine; Biomarkers; Blood Glucose; Cell Adhesion Molecules; Comorbidity; Creatinine; Diabetes Mellitus; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Hypertension; Inflammation; Kidney Function Tests; Lipids; Male; Middle Aged; Nitric Oxide; Renal Insufficiency, Chronic; Risk; Sensitivity and Specificity; Thrombophilia; Vasodilation; von Willebrand Factor; Young Adult

2015
Asymmetric and Symmetric Dimethylarginine and Sympathetic Nerve Traffic after Renal Denervation in Patients with Resistant Hypertension.
    Clinical journal of the American Society of Nephrology : CJASN, 2015, Sep-04, Volume: 10, Issue:9

    Topics: Aged; Arginine; Blood Pressure; Drug Resistance; Female; Heart Rate; Humans; Hypertension; Longitudinal Studies; Male; Middle Aged; Muscle, Skeletal; Sympathectomy; Sympathetic Nervous System

2015
Reduction in asymmetric dimethylarginine plasma levels by coenzyme Q10 supplementation in patients with type 2 diabetes mellitus.
    Minerva endocrinologica, 2015, Volume: 40, Issue:4

    Topics: Adult; Aged; Antioxidants; Arginine; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Supplements; Double-Blind Method; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Ubiquinone

2015
Angiotensin converting enzyme inhibition increases ADMA concentration in patients on maintenance hemodialysis--a randomized cross-over study.
    BMC nephrology, 2015, Oct-22, Volume: 16

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Arginine; Bradykinin; Cell Line; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Ramipril; Renal Dialysis; Valsartan

2015
Microvascular effects of the inhibition of dipeptidylpeptidase IV by linagliptin in nondiabetic hypertensive patients.
    Journal of hypertension, 2016, Volume: 34, Issue:2

    Topics: Aged; Arginine; Arterial Pressure; C-Reactive Protein; Cyclic GMP; Cystatin C; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Female; Glycated Hemoglobin; Humans; Hypertension; Linagliptin; Male; Microvessels; Middle Aged; Regional Blood Flow; Retinal Vessels; Transforming Growth Factor beta1

2016
Association of Serum Asymmetric Dimethylarginine With Muscle Strength and Gait Speed: A Cross-Sectional Study of the HEIJO-KYO Cohort.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2016, Volume: 31, Issue:5

    Topics: Aged; Aged, 80 and over; Arginine; Cohort Studies; Cross-Sectional Studies; Female; Gait; Hand Strength; Humans; Male; Middle Aged; Quadriceps Muscle

2016
Asymmetric Dimethylarginine Limits the Efficacy of Simvastatin Activating Endothelial Nitric Oxide Synthase.
    Journal of the American Heart Association, 2016, Apr-18, Volume: 5, Issue:4

    Topics: Aged; Animals; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Activation; Female; Humans; Male; Mice; Nitric Oxide; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Signal Transduction; Simvastatin

2016
Effect of the transdermal low-level laser therapy on endothelial function.
    Lasers in medical science, 2016, Volume: 31, Issue:7

    Topics: Adult; Angiostatins; Arginine; Female; Fibroblast Growth Factors; Glutathione; Humans; Lasers, Semiconductor; Low-Level Light Therapy; Male; Nitric Oxide; Vascular Endothelial Growth Factor A

2016
Effect of trelagliptin on vascular endothelial functions and serum adiponectin level in patients with type 2 diabetes: a preliminary single-arm prospective pilot study.
    Cardiovascular diabetology, 2016, 11-04, Volume: 15, Issue:1

    Topics: Adiponectin; Adult; Aged; Arginine; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Endothelium, Vascular; Female; Glycated Hemoglobin; Humans; Japan; Male; Middle Aged; Pilot Projects; Prospective Studies; Time Factors; Treatment Outcome; Up-Regulation; Uracil; Vasodilation

2016
Effects of Vitamin D3 on asymmetric- and symmetric dimethylarginine in arterial hypertension.
    The Journal of steroid biochemistry and molecular biology, 2018, Volume: 175

    Topics: Aged; Analysis of Variance; Arginine; Blood Pressure; Cholecalciferol; Dietary Supplements; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Vitamin D; Vitamin D Deficiency

2018
Serum Asymmetric and Symmetric Dimethylarginine and Morbidity and Mortality in Hemodialysis Patients.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017, Volume: 70, Issue:1

    Topics: Arginine; Cardiovascular Diseases; Female; Humans; Male; Middle Aged; Morbidity; Prospective Studies; Renal Dialysis

2017
Genetic variations in the alanine-glyoxylate aminotransferase 2 (AGXT2) gene and dimethylarginines levels in rheumatoid arthritis.
    Amino acids, 2017, Volume: 49, Issue:6

    Topics: Aged; Arginine; Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Transaminases

2017
Effect of Febuxostat on the Endothelial Dysfunction in Hemodialysis Patients: A Randomized, Placebo-Controlled, Double-Blinded Study.
    American journal of nephrology, 2017, Volume: 45, Issue:5

    Topics: Administration, Oral; Adult; Alanine Transaminase; Arginine; Aspartate Aminotransferases; C-Reactive Protein; Cardiovascular Diseases; Double-Blind Method; Endothelium, Vascular; Enzyme Inhibitors; Febuxostat; Female; Humans; Incidence; Kidney Failure, Chronic; Male; Middle Aged; Pancytopenia; Placebos; Prospective Studies; Renal Dialysis; Risk Factors; Treatment Outcome; Uric Acid; Xanthine Oxidase

2017
Does Vitamin D Status Correlate with Cardiometabolic Risk Factors in Adults with Growth Hormone Deficiency?
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2017, Volume: 49, Issue:7

    Topics: 25-Hydroxyvitamin D 2; Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Blood Glucose; C-Reactive Protein; Female; Human Growth Hormone; Humans; Insulin; Male; Metabolic Syndrome; Middle Aged; Uric Acid

2017
Improvement in asymmetric dimethylarginine and oxidative stress in patients with limb salvage after autologous mononuclear stem cell application for critical limb ischemia.
    Stem cell research & therapy, 2017, 07-12, Volume: 8, Issue:1

    Topics: Aged; Arginine; Autografts; Extremities; Female; Follow-Up Studies; Humans; Ischemia; Leukocytes, Mononuclear; Male; Middle Aged; Oxidative Stress; Stem Cell Transplantation; Stem Cells

2017
Dietary Plant Sterols Supplementation Increases In Vivo Nitrite and Nitrate Production in Healthy Adults: A Randomized, Controlled Study.
    Journal of food science, 2017, Volume: 82, Issue:7

    Topics: Adult; Arginine; Cholesterol; Cross-Over Studies; Dietary Supplements; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Nitrates; Nitrites; Phytosterols; Young Adult

2017
Impact of Asymmetric Dimethylarginine on Coronary Physiology Early After Heart Transplantation.
    The American journal of cardiology, 2017, Sep-15, Volume: 120, Issue:6

    Topics: Arginine; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Follow-Up Studies; Fractional Flow Reserve, Myocardial; Heart Transplantation; Humans; Male; Microcirculation; Middle Aged; Prognosis; Prospective Studies; Time Factors; Vascular Resistance

2017
Associations of Plasma Nitrite, L-Arginine and Asymmetric Dimethylarginine With Morbidity and Mortality in Patients With Necrotizing Soft Tissue Infections.
    Shock (Augusta, Ga.), 2018, Volume: 49, Issue:6

    Topics: Adult; Aged; Arginine; Biomarkers; Disease-Free Survival; Female; Hospital Mortality; Humans; Male; Middle Aged; Nitrites; Prospective Studies; Severity of Illness Index; Shock, Septic; Soft Tissue Infections; Survival Rate; Time Factors

2018
Vitamin D and methylarginines in chronic kidney disease (CKD).
    PloS one, 2017, Volume: 12, Issue:10

    Topics: Aged; Arginine; Calcium; Cross-Sectional Studies; Double-Blind Method; Ergocalciferols; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Parathyroid Hormone; Placebos; Vitamin D

2017
Effect of statin on arginine metabolites in treated HIV-infection.
    Atherosclerosis, 2017, Volume: 266

    Topics: Adult; Anti-HIV Agents; Arginine; Biomarkers; Carotid Artery Diseases; Carotid Intima-Media Thickness; Chi-Square Distribution; Cholesterol, LDL; Double-Blind Method; Female; HIV Infections; HIV-1; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Linear Models; Male; Middle Aged; Ohio; Risk Factors; RNA, Viral; Rosuvastatin Calcium; Time Factors; Treatment Outcome; Viral Load

2017
Renin-angiotensin system blockade promotes a cardio-renal protection in albuminuric homozygous sickle cell patients.
    British journal of haematology, 2017, Volume: 179, Issue:5

    Topics: Adult; Albuminuria; Anemia, Sickle Cell; Angiotensin-Converting Enzyme Inhibitors; Arginine; Biomarkers; Blood Pressure; Creatinine; Female; Glomerular Filtration Rate; Humans; Male; Pulse Wave Analysis; Renin-Angiotensin System; Tricuspid Valve Insufficiency

2017
How does spa treatment affect cardiovascular function and vascular endothelium in patients with generalized osteoarthritis? A pilot study through plasma asymmetric di-methyl arginine (ADMA) and L-arginine/ADMA ratio.
    International journal of biometeorology, 2018, Volume: 62, Issue:5

    Topics: Aged; Arginine; Balneology; Blood Pressure; Endothelium, Vascular; Female; Heart Rate; Humans; Male; Middle Aged; Osteoarthritis; Pilot Projects

2018
Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction.
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2018, Volume: 23, Issue:6

    Topics: Aged; Arginine; Biomarkers; Exercise Therapy; Female; Follow-Up Studies; Heart Failure; Humans; Male; Middle Aged; Nitric Oxide; Prospective Studies; Signal Transduction; Stroke Volume

2018
Hemodiafiltration is associated with reduced inflammation, oxidative stress and improved endothelial risk profile compared to high-flux hemodialysis in children.
    PloS one, 2018, Volume: 13, Issue:6

    Topics: Adolescent; Arginine; Biomarkers; Child; Female; Hemodiafiltration; Humans; Inflammation; Male; Oxidative Stress; Prospective Studies; Treatment Outcome

2018
Asymmetric dimethylarginine and soluble inter-cellular adhesion molecule-1 serum levels alteration following ginger supplementation in patients with type 2 diabetes: a randomized double-blind, placebo-controlled clinical trial.
    Journal of complementary & integrative medicine, 2018, Aug-11, Volume: 16, Issue:2

    Topics: Adult; Arginine; Biomarkers; Diabetes Mellitus, Type 2; Dietary Supplements; Double-Blind Method; Female; Humans; Intercellular Adhesion Molecule-1; Male; Middle Aged; Plant Extracts; Zingiber officinale

2018
Asymmetric dimethylarginine serum levels are associated with early mortality after allogeneic stem cell transplantation.
    Haematologica, 2019, Volume: 104, Issue:4

    Topics: Allografts; Arginine; Disease-Free Survival; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Risk Factors; Survival Rate

2019
Serum Levels of Protein-Bound Methylglyoxal-Derived Hydroimidazolone-1 are Independently Correlated with Asymmetric Dimethylarginine.
    Rejuvenation research, 2019, Volume: 22, Issue:5

    Topics: Aged; Arginine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glucose Intolerance; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Imidazoles; Inflammation; Male; Middle Aged; Protein Binding; Pyruvaldehyde; Vascular Stiffness

2019
The Effect of Vitamin D on Serum Asymmetric Dimethylarginine in Patients with Mild to Moderate Ulcerative Colitis.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 2020, Volume: 90, Issue:1-2

    Topics: Arginine; Colitis, Ulcerative; Humans; Vitamin D; Vitamins

2020
Effects of Selenium Supplementation on Asymmetric Dimethylarginine and Cardiometabolic Risk Factors in Patients with Polycystic Ovary Syndrome.
    Biological trace element research, 2020, Volume: 196, Issue:2

    Topics: Adolescent; Adult; Arginine; Cardiometabolic Risk Factors; Dietary Supplements; Double-Blind Method; Female; Humans; Middle Aged; Polycystic Ovary Syndrome; Selenium; Testosterone; Young Adult

2020
L-Citrulline increases nitric oxide and improves control in obese asthmatics.
    JCI insight, 2019, 12-19, Volume: 4, Issue:24

    Topics: Adult; Aged; Arginine; Asthma; Citrulline; Dietary Supplements; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Obesity; Oxidative Stress; Pilot Projects; Proof of Concept Study; Severity of Illness Index; Treatment Outcome; Young Adult

2019
Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial.
    Nutrients, 2020, 05-07, Volume: 12, Issue:5

    Topics: Adult; Arginine; Blood Pressure; Carotid Intima-Media Thickness; Diet Therapy; Endothelium, Vascular; Exercise Therapy; Female; Healthy Lifestyle; Humans; Hypertension; Male; Middle Aged; Severity of Illness Index; Treatment Outcome; Vascular Stiffness

2020
The Effect of Corrected Inflammation, Oxidative Stress and Endothelial Dysfunction on Fmd Levels in Patients with Selected Chronic Diseases: A Quasi-Experimental Study.
    Scientific reports, 2020, 06-02, Volume: 10, Issue:1

    Topics: Adult; Aged; Antioxidants; Arginine; Atherosclerosis; C-Reactive Protein; Chronic Disease; Dietary Supplements; Endothelium, Vascular; Fatty Acids, Omega-3; Female; Humans; Inflammation; Male; Malondialdehyde; Middle Aged; Morinda; Oxidative Stress; Serum Amyloid P-Component; Vasodilation

2020
ADMA mediates gastric cancer cell migration and invasion via Wnt/β-catenin signaling pathway.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2021, Volume: 23, Issue:2

    Topics: Adenocarcinoma; Arginine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Invasiveness; Prognosis; Stomach Neoplasms; Wnt Signaling Pathway; Wound Healing

2021
Resistance training improves sleep quality, redox balance and inflammatory profile in maintenance hemodialysis patients: a randomized controlled trial.
    Scientific reports, 2020, 07-16, Volume: 10, Issue:1

    Topics: Aged; Arginine; Biomarkers; Endothelium; Humans; Inflammation; Male; Middle Aged; Muscle Strength; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Renal Dialysis; Renal Insufficiency, Chronic; Resistance Training; Sleep; Sleep Wake Disorders; Treatment Outcome

2020
Asymmetric dimethylarginine predicts perioperative cardiovascular complications in patients undergoing medium-to-high risk non-cardiac surgery.
    The Journal of international medical research, 2020, Volume: 48, Issue:8

    Topics: Arginine; C-Reactive Protein; Citrulline; Humans; Prospective Studies

2020
Randomized, Open-Label, Cross-Over Comparison of the Effects of Benzbromarone and Febuxostat on Endothelial Function in Patients with Hyperuricemia.
    International heart journal, 2020, Sep-29, Volume: 61, Issue:5

    Topics: Adiponectin; Aged; Arginine; Benzbromarone; Cross-Over Studies; Endothelium, Vascular; Febuxostat; Female; Gout Suppressants; Humans; Hyperemia; Hyperuricemia; Male; Middle Aged; Organic Anion Transporters; Organic Cation Transport Proteins; Treatment Outcome; Uric Acid; Uricosuric Agents; Xanthine Oxidase

2020
A high-protein meal does not improve blood pressure or vasoactive biomarker responses to acute exercise in humans.
    Nutrition research (New York, N.Y.), 2020, Volume: 81

    Topics: Adult; Arginine; Biomarkers; Blood Pressure; Cross-Over Studies; Dietary Fats; Dietary Proteins; Double-Blind Method; Exercise; Female; Humans; Male; Meals; Postprandial Period

2020
Combination Treatment with Sodium Nitrite and Isoquercetin on Endothelial Dysfunction among Patients with CKD: A Randomized Phase 2 Pilot Trial.
    Clinical journal of the American Society of Nephrology : CJASN, 2020, 11-06, Volume: 15, Issue:11

    Topics: Aged; Amine Oxidase (Copper-Containing); Antioxidants; Arginine; Biomarkers; Cell Adhesion Molecules; Drug Therapy, Combination; E-Selectin; Endostatins; Endothelium; Female; Glomerular Filtration Rate; Humans; Inflammation; Intercellular Adhesion Molecule-1; Male; Medication Adherence; Middle Aged; Oxidative Stress; Pilot Projects; Quercetin; Renal Insufficiency, Chronic; Sodium Nitrite; Vasodilation; von Willebrand Factor

2020
Role of endothelial function determined by asymmetric dimethylarginine in the prediction of resistant hypertension: A subanalysis of ReHOT trial.
    Journal of clinical hypertension (Greenwich, Conn.), 2020, Volume: 22, Issue:11

    Topics: Antihypertensive Agents; Arginine; Blood Pressure; Humans; Hypertension

2020
Effects of virgin coconut oil consumption on metabolic syndrome components and asymmetric dimethylarginine: A randomized controlled clinical trial.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2021, 03-10, Volume: 31, Issue:3

    Topics: Adult; Arginine; Biomarkers; Blood Glucose; Coconut Oil; Dietary Fats; Female; Humans; Iran; Lipids; Male; Metabolic Syndrome; Middle Aged; Time Factors; Young Adult

2021
Whole-Body Cryotherapy Increases the Activity of Nitric Oxide Synthase in Older Men.
    Biomolecules, 2021, 07-16, Volume: 11, Issue:7

    Topics: Aged; Arginine; Athletes; Body Mass Index; Cryotherapy; Exercise; Humans; Interleukins; Male; Middle Aged; Nitric Oxide Synthase Type II; Oxidative Stress; Physical Endurance; Tyrosine

2021
Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial.
    PloS one, 2021, Volume: 16, Issue:9

    Topics: Adult; Aged; Arginine; Atherosclerosis; Biomarkers; Brachial Artery; Dilatation, Pathologic; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Japan; Male; Mandible; Maxilla; Middle Aged; Oral Hygiene; Periodontal Diseases; Self Care; Treatment Outcome; Young Adult

2021
Effects of treatment with SGLT-2 inhibitors on arginine-related cardiovascular and renal biomarkers.
    Cardiovascular diabetology, 2022, 01-06, Volume: 21, Issue:1

    Topics: Arginine; Benzhydryl Compounds; Biomarkers; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucosides; Glycated Hemoglobin; Humans; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Sodium-Glucose Transporter 2 Inhibitors; Time Factors; Treatment Outcome

2022
The impact of probiotic yogurt versus ordinary yogurt on serum sTWEAK, sCD163, ADMA, LCAT and BUN in patients with chronic heart failure: a randomized, triple-blind, controlled trial.
    Journal of the science of food and agriculture, 2022, Volume: 102, Issue:13

    Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Arginine; Blood Urea Nitrogen; Cytokine TWEAK; Heart Failure; Humans; Phosphatidylcholine-Sterol O-Acyltransferase; Probiotics; Receptors, Cell Surface; Tumor Necrosis Factor-alpha; Yogurt

2022
Vitamin D Supplementation Influences Ultramarathon-Induced Changes in Serum Amino Acid Levels, Tryptophan/Branched-Chain Amino Acid Ratio, and Arginine/Asymmetric Dimethylarginine Ratio.
    Nutrients, 2023, Aug-11, Volume: 15, Issue:16

    Topics: Amino Acids; Amino Acids, Branched-Chain; Arginine; Dietary Supplements; Humans; Male; Tryptophan; Vitamin D; Vitamins

2023

Other Studies

1651 other study(ies) available for n,n-dimethylarginine and arginine

ArticleYear
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia.
    The Journal of biological chemistry, 2007, Nov-30, Volume: 282, Issue:48

    Topics: Amidohydrolases; Amino Acid Sequence; Animals; Binding Sites; Cloning, Molecular; Cysteine; Dose-Response Relationship, Drug; Drug Design; Homocysteine; Humans; Hydrogen Peroxide; Hyperhomocysteinemia; Kinetics; Molecular Sequence Data; Oxidation-Reduction; Sequence Homology, Amino Acid; Substrate Specificity

2007
Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis.
    Journal of cardiovascular pharmacology, 1992, Volume: 20 Suppl 12

    Topics: Amino Acid Oxidoreductases; Arginine; Chromatography, High Pressure Liquid; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Nitric Oxide; Nitric Oxide Synthase

1992
Methylations of 70,000-Da heat shock proteins in 3T3 cells: alterations by arsenite treatment, by different stages of growth and by virus transformation.
    Archives of biochemistry and biophysics, 1992, Aug-15, Volume: 297, Issue:1

    Topics: 3T3 Cells; Animals; Arginine; Arsenic; Arsenites; Avian Sarcoma Viruses; Cell Division; Cell Transformation, Viral; Chromatography, Ion Exchange; Electrophoresis, Gel, Two-Dimensional; Heat-Shock Proteins; Lysine; Methionine; Methylation; Mice; Molecular Weight; omega-N-Methylarginine

1992
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure.
    Lancet (London, England), 1992, Mar-07, Volume: 339, Issue:8793

    Topics: Adult; Animals; Aorta; Arginine; Blood Pressure; Cells, Cultured; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Forearm; Guinea Pigs; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; omega-N-Methylarginine; Rats; Reference Values; Regional Blood Flow

1992
Distribution of free methylarginines in rat tissues and in the bovine brain.
    Journal of neurochemistry, 1992, Volume: 59, Issue:6

    Topics: Animals; Arginine; Brain Chemistry; Cattle; Intestines; Male; Myocardium; omega-N-Methylarginine; Rats; Rats, Wistar; Spleen; Testis; Tissue Distribution

1992
Isolation and identification of methylarginines from bovine brain.
    Journal of neurochemistry, 1992, Volume: 58, Issue:3

    Topics: Animals; Arginine; Brain; Cattle; Chromatography, High Pressure Liquid; Electrophoresis, Paper; omega-N-Methylarginine

1992
Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pI, 8.5) rich in NG,NG-dimethylarginine.
    The Journal of biological chemistry, 1985, Nov-15, Volume: 260, Issue:26

    Topics: Amino Acid Sequence; Amino Acids; Animals; Antigens; Arginine; Autoantibodies; Cell Nucleolus; Fluorescent Antibody Technique; Histocytochemistry; Humans; Immunologic Techniques; Immunosorbent Techniques; Liver Neoplasms, Experimental; Microscopy, Electron; Molecular Weight; Physarum; Proteins; RNA; Scleroderma, Systemic

1985
Metabolism of NG,NG-and NG,N'G-dimethylarginine in rats.
    Archives of biochemistry and biophysics, 1987, Feb-01, Volume: 252, Issue:2

    Topics: Animals; Arginine; Carbon Dioxide; Gas Chromatography-Mass Spectrometry; Isomerism; Rats; Tissue Distribution

1987
The nucleolar protein, B-36, contains a glycine and dimethylarginine-rich sequence conserved in several other nuclear RNA-binding proteins.
    Biochemical and biophysical research communications, 1988, Sep-30, Volume: 155, Issue:3

    Topics: Amino Acid Sequence; Arginine; Carrier Proteins; Glycine; Molecular Sequence Data; Molecular Weight; Nuclear Proteins; Physarum; Protein O-Methyltransferase; RNA-Binding Proteins

1988
Occurrence of a new enzyme catalyzing the direct conversion of NG,NG-dimethyl-L-arginine to L-citrulline in rats.
    Biochemical and biophysical research communications, 1987, Oct-29, Volume: 148, Issue:2

    Topics: Amidohydrolases; Animals; Arginine; Citrulline; Female; Hydrolases; Kidney; Mass Spectrometry; Rats; Rats, Inbred Strains

1987
Protein and cDNA sequence of a glycine-rich, dimethylarginine-containing region located near the carboxyl-terminal end of nucleolin (C23 and 100 kDa).
    The Journal of biological chemistry, 1986, Jul-15, Volume: 261, Issue:20

    Topics: Amino Acid Sequence; Animals; Arginine; Base Sequence; Cricetinae; Cricetulus; DNA; DNA, Recombinant; Female; Glycine; Liver Neoplasms, Experimental; Nucleolin; Nucleoproteins; Ovary; Peptide Fragments; Phosphoproteins; Protein Processing, Post-Translational; RNA-Binding Proteins

1986
Clustering of glycine and NG,NG-dimethylarginine in nucleolar protein C23.
    Biochemistry, 1985, Oct-22, Volume: 24, Issue:22

    Topics: Amino Acid Sequence; Animals; Arginine; Glycine; Liver Neoplasms, Experimental; Molecular Weight; Nuclear Proteins; Nucleophosmin; Peptide Fragments; Rats; Ribonucleoproteins; Structure-Activity Relationship; Trypsin

1985
Urinary excretion of dimethylarginines in premature infants.
    Biochemical medicine, 1984, Volume: 32, Issue:2

    Topics: Adolescent; Adult; Aging; Arginine; Body Weight; Child; Child, Preschool; Diet; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Premature; Male; Methylhistidines; Muscle Proteins; Nitrogen; Proteins

1984
Characterization of glycine-rich proteins from the ribonucleoproteins containing heterogeneous nuclear ribonucleic acid.
    Biochemistry, 1980, Mar-18, Volume: 19, Issue:6

    Topics: Arginine; Glycine; Molecular Weight; Nucleoproteins; Peptide Fragments; Ribonucleoproteins; RNA, Heterogeneous Nuclear; Thermolysin; Trypsin

1980
Response of cerebral blood vessels to an endogenous inhibitor of nitric oxide synthase.
    The American journal of physiology, 1995, Volume: 269, Issue:5 Pt 2

    Topics: Animals; Arginine; Basilar Artery; Brain; Cerebellum; Cerebrovascular Circulation; Citrulline; Nitric Oxide Synthase; Rabbits; Rats; Rats, Sprague-Dawley

1995
Effects of guanidino and uremic compounds on nitric oxide pathways.
    Kidney international, 1994, Volume: 45, Issue:3

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Guanidines; Humans; Macrophages; Mice; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Saphenous Vein

1994
Metabolism of methylarginines by human vasculature; implications for the regulation of nitric oxide synthesis.
    British journal of pharmacology, 1994, Volume: 112, Issue:1

    Topics: Amino Acid Oxidoreductases; Arginase; Arginine; Cells, Cultured; Chromatography, High Pressure Liquid; Citrulline; Cytosol; Endothelium, Vascular; Humans; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Saphenous Vein; Umbilical Veins

1994
Accumulation of an endogenous inhibitor of nitric oxide synthase during graded hemorrhagic shock.
    Circulatory shock, 1994, Volume: 44, Issue:3

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Cardiac Output; Nitric Oxide Synthase; Shock, Hemorrhagic; Swine; Vascular Resistance

1994
Effects of an endogenous inhibitor of nitric oxide synthesis on postcapillary venules.
    The American journal of physiology, 1995, Volume: 268, Issue:6 Pt 2

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Flow Velocity; Blood Platelets; Cell Adhesion; Cell Aggregation; Endothelium, Vascular; Kinetics; Leukocytes; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Splanchnic Circulation; Stereoisomerism; Venules

1995
Urinary excretion of NG-dimethylarginines in multiple sclerosis patients: preliminary observations.
    Journal of the neurological sciences, 1995, Volume: 129, Issue:2

    Topics: Arginine; Case-Control Studies; Chromatography, High Pressure Liquid; Humans; Multiple Sclerosis; Reference Values; Sensitivity and Specificity

1995
Peptides with sequences similar to glycine, arginine-rich motifs in proteins interacting with RNA are efficiently recognized by methyltransferase(s) modifying arginine in numerous proteins.
    The Journal of biological chemistry, 1993, May-15, Volume: 268, Issue:14

    Topics: Amino Acid Sequence; Animals; Arginine; Brain; Cattle; Chromosomal Proteins, Non-Histone; Glycine; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Methylation; Methyltransferases; Molecular Sequence Data; Nuclear Proteins; Nucleolin; PC12 Cells; Peptides; Phosphoproteins; Protein-Arginine N-Methyltransferases; Ribonucleoproteins; RNA; RNA-Binding Proteins; Sequence Homology, Amino Acid; Substrate Specificity

1993
Plasma concentrations of endogenous inhibitor of nitric oxide synthesis in normal pregnancy and pre-eclampsia.
    Lancet (London, England), 1993, Jul-24, Volume: 342, Issue:8865

    Topics: Animals; Arginine; Female; Humans; Hypertension; Nitric Oxide; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Sheep

1993
Increase of an endogenous inhibitor of nitric oxide synthesis in serum of high cholesterol fed rabbits.
    Life sciences, 1994, Volume: 54, Issue:12

    Topics: Animals; Arginine; Arteriosclerosis; Cholesterol, Dietary; Creatine; Lipids; Male; Nitric Oxide; Rabbits

1994
Regional and cardiac haemodynamic effects of NG, NG,dimethyl-L-arginine and their reversibility by vasodilators in conscious rats.
    British journal of pharmacology, 1993, Volume: 110, Issue:4

    Topics: Animals; Arginine; Glutathione; Hemodynamics; Hydralazine; Male; Nitroprusside; Nitroso Compounds; omega-N-Methylarginine; Penicillamine; Rats; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Vasodilator Agents

1993
Effect of local intra-arterial asymmetric dimethylarginine (ADMA) on the forearm arteriolar bed of healthy volunteers.
    Journal of human hypertension, 1993, Volume: 7, Issue:2

    Topics: Adult; Arginine; Arterioles; Female; Forearm; Humans; Injections, Intra-Arterial; Male; Regional Blood Flow; Vascular Resistance

1993
Regulation of nitric oxide synthesis in uraemia.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1995, Volume: 10, Issue:8

    Topics: Analysis of Variance; Animals; Arginine; Chronic Disease; Dialysis Solutions; Endothelium, Vascular; Female; Humans; Male; Mice; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Renal Dialysis; Uremia

1995
Peritoneal dialysis solutions reverse the hemodynamic effects of nitric oxide synthesis inhibitors.
    Kidney international, 1995, Volume: 48, Issue:6

    Topics: Animals; Arginine; Dialysis Solutions; Enzyme Inhibitors; Hemodynamics; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peritoneal Dialysis; Rats; Rats, Sprague-Dawley; Renal Insufficiency

1995
Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits.
    Biochemical and biophysical research communications, 1996, Feb-15, Volume: 219, Issue:2

    Topics: Arginine; Cholesterol, Dietary; Chromatography, High Pressure Liquid; Diet; Food, Fortified; Hypercholesterolemia; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Reference Values

1996
Accumulation of the endogenous L-arginine analogue NG-monomethyl-L-arginine in human end-stage renal failure patients on regular haemodialysis.
    Experimental physiology, 1996, Volume: 81, Issue:3

    Topics: Adult; Arginine; Biological Transport; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Erythrocytes; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase; Renal Dialysis; Scintillation Counting; Uremia

1996
Effect of asymmetric dimethyl arginine on nitric oxide synthase activity in normal and pre-eclamptic placentae.
    Reproduction, fertility, and development, 1995, Volume: 7, Issue:6

    Topics: Arginine; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Nitric Oxide Synthase; Placenta; Pre-Eclampsia; Pregnancy

1995
Central and peripheral effects of asymmetric dimethylarginine, an endogenous nitric oxide synthetase inhibitor.
    Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:3

    Topics: Animals; Aorta; Arginine; Baroreflex; Dose-Response Relationship, Drug; Hemodynamics; In Vitro Techniques; Injections, Intravenous; Injections, Intraventricular; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley

1996
Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension.
    Hypertension (Dallas, Tex. : 1979), 1997, Volume: 29, Issue:1 Pt 2

    Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Hydrolases; Hypertension; Kidney; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium Chloride, Dietary; Species Specificity

1997
High-performance liquid chromatographic determination of nitric oxide synthase-related arginine derivatives in vitro and in vivo.
    Analytical biochemistry, 1997, Apr-05, Volume: 247, Issue:1

    Topics: Animals; Arginine; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Female; Humans; In Vitro Techniques; Macrophages, Alveolar; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Reference Values; Reproducibility of Results; Sensitivity and Specificity

1997
Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease.
    Circulation, 1997, Apr-15, Volume: 95, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Aging; Arginine; Arterial Occlusive Diseases; Cyclic GMP; Disease Progression; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Peripheral Vascular Diseases; Vasodilation

1997
Identification of N(G)-methylarginine residues in human heterogeneous RNP protein A1: Phe/Gly-Gly-Gly-Arg-Gly-Gly-Gly/Phe is a preferred recognition motif.
    Biochemistry, 1997, Apr-29, Volume: 36, Issue:17

    Topics: Amino Acid Sequence; Arginine; Chromatography, High Pressure Liquid; Enzyme Inhibitors; HeLa Cells; Heterogeneous Nuclear Ribonucleoprotein A1; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Heterogeneous-Nuclear Ribonucleoproteins; Humans; Methylation; Molecular Sequence Data; Peptide Mapping; Ribonucleoproteins; RNA-Binding Proteins; RNA, Heterogeneous Nuclear; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

1997
Effect of nicotine on the intimal hyperplasia after endothelial removal of the rabbit carotid artery.
    General pharmacology, 1997, Volume: 28, Issue:5

    Topics: Animals; Arginine; Body Weight; Carotid Arteries; Endothelin-1; Endothelium, Vascular; Hyperplasia; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nicotine; Nitric Oxide Synthase; omega-N-Methylarginine; Rabbits; Tunica Intima

1997
Determination of dimethylated arginines in human plasma by high-performance liquid chromatography.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, May-09, Volume: 692, Issue:2

    Topics: Arginine; Chromatography, High Pressure Liquid; Humans; Isomerism; Spectrometry, Fluorescence

1997
Determination of N(G),N(G)-dimethylarginine in human plasma by high-performance liquid chromatography.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, May-09, Volume: 692, Issue:2

    Topics: Amino Acids; Arginine; Chromatography, High Pressure Liquid; Female; Humans; Pregnancy; Pregnancy Complications, Cardiovascular; Reproducibility of Results

1997
A possible role of endogenous inhibitor for nitric oxide synthesis in the bovine ciliary muscle.
    Experimental eye research, 1997, Volume: 64, Issue:5

    Topics: Animals; Arginine; Calcimycin; Cattle; Ciliary Body; Ionophores; Muscle Relaxation; Nitric Oxide; Nitroprusside; omega-N-Methylarginine

1997
Nitric oxide synthase inhibitors and hypertension in children and adolescents.
    Journal of hypertension, 1997, Volume: 15, Issue:8

    Topics: Adolescent; Animals; Arginine; Child; Endothelium, Vascular; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Humans; Hypertension; Hypertension, Renal; Hypertension, Renovascular; In Vitro Techniques; Male; Mice; Muscle Contraction; Nitric Oxide Synthase; omega-N-Methylarginine; Phenylephrine; Renin; Vasoconstrictor Agents

1997
Serum levels of NG, NG-dimethyl-L-arginine, a potential endogenous nitric oxide inhibitor in dialysis patients.
    Journal of the American Society of Nephrology : JASN, 1997, Volume: 8, Issue:9

    Topics: Arginine; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Humans; Nitric Oxide; omega-N-Methylarginine; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis

1997
The arginine-nitric oxide pathway in thrombotic microangiopathy.
    Scandinavian journal of urology and nephrology, 1997, Volume: 31, Issue:5

    Topics: Adult; Aged; Arginine; Child, Preschool; Enzyme Inhibitors; Hemolytic-Uremic Syndrome; Humans; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Plasma; Plasmapheresis; Purpura, Thrombotic Thrombocytopenic; Recurrence

1997
Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney.
    Kidney international, 1997, Volume: 52, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Enzyme Inhibitors; Hydrolases; Kidney Glomerulus; Loop of Henle; Male; Methylation; Microscopy, Immunoelectron; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Tritium

1997
Determination of dimethylated arginines in human plasma by high-performance liquid chromatography.
    Journal of chromatography. B, Biomedical sciences and applications, 1998, Jan-23, Volume: 705, Issue:1

    Topics: Arginine; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Humans; Indicators and Reagents; Nitric Oxide Synthase; o-Phthalaldehyde; Spectrometry, Fluorescence; Stereoisomerism

1998
Elevation of an endogenous inhibitor of nitric oxide synthesis in experimental congestive heart failure.
    Cardiovascular research, 1998, Volume: 37, Issue:3

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Endothelium, Vascular; Heart Failure; Kidney; Male; Metabolic Clearance Rate; Nitric Oxide Synthase; Nitroprusside; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Renal Circulation; Vasodilation; Vasodilator Agents

1998
Enzymatic methylation of recombinant TIS21 protein-arginine residues.
    Biochemistry and molecular biology international, 1998, Volume: 45, Issue:5

    Topics: Arginine; Escherichia coli; Immediate-Early Proteins; Methylation; Protein-Arginine N-Methyltransferases; Recombinant Proteins

1998
Endogenous inhibitors of nitric oxide synthesis and lipid peroxidation in hyperlipidemic rabbits.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1996, Volume: 17, Issue:2

    Topics: Animals; Aorta, Thoracic; Arginine; Hyperlipidemias; Lipid Peroxidation; Male; Malondialdehyde; Nitric Oxide; Rabbits; Vasodilation; Vitamin E

1996
Endogenous asymmetrical dimethylarginine and hypertension associated with puromycin nephrosis in the rat.
    British journal of pharmacology, 1998, Volume: 125, Issue:3

    Topics: Animals; Arginine; Blood Pressure; Body Weight; Cyclic GMP; Endothelium; Glomerulosclerosis, Focal Segmental; Hypertension; Kidney; Male; Nitrous Oxide; Puromycin Aminonucleoside; Rats; Rats, Sprague-Dawley

1998
The nitric oxide system and cortisol-induced hypertension in humans.
    Clinical and experimental pharmacology & physiology, 1998, Volume: 25, Issue:11

    Topics: Arginine; Humans; Hydrocortisone; Hypertension; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites

1998
Effect of inhibition of nitric oxide synthase on Pseudomonas aeruginosa infection of respiratory mucosa in vitro.
    American journal of respiratory cell and molecular biology, 1998, Volume: 19, Issue:6

    Topics: Arginine; Bacterial Adhesion; Enzyme Inhibitors; Gene Expression; Humans; Microscopy, Electron, Scanning; Mucous Membrane; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; omega-N-Methylarginine; Organ Culture Techniques; Pseudomonas aeruginosa; Respiratory System; RNA, Messenger

1998
Hemodialysis hypotension: interaction of inhibitors, iNOS, and the interdialytic period.
    The American journal of the medical sciences, 1999, Volume: 317, Issue:1

    Topics: Adult; Arginine; Blood Pressure; Blotting, Western; Enzyme Inhibitors; Female; Humans; Hypotension; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Regression Analysis; Renal Dialysis

1999
Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia.
    British journal of pharmacology, 1999, Volume: 126, Issue:1

    Topics: Alloxan; Animals; Arginine; Blood Glucose; Body Weight; Carotid Arteries; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Hyperglycemia; Hyperplasia; In Vitro Techniques; Male; Nitric Oxide; omega-N-Methylarginine; Rabbits; Tunica Intima; Tunica Media; Weight Gain

1999
Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis.
    Circulation, 1999, Mar-09, Volume: 99, Issue:9

    Topics: Adult; Aged; Arginine; Arteriosclerosis; Biomarkers; Carotid Artery, Common; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Risk Factors; Tunica Intima

1999
[Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis].
    Journal of cardiology, 1999, Volume: 33, Issue:2

    Topics: Arginine; Biomarkers; Coronary Artery Disease; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase

1999
Nitric oxide metabolites, cyclic guanosine 3,5 monophosphate and dimethylarginines during and after uncomplicated pregnancies: a longitudinal study.
    European journal of obstetrics, gynecology, and reproductive biology, 1999, Volume: 82, Issue:1

    Topics: Adult; Arginine; Chromatography, High Pressure Liquid; Creatinine; Cyclic GMP; Enzyme Inhibitors; Ethylenediamines; Female; Free Radical Scavengers; Humans; Immunoenzyme Techniques; Longitudinal Studies; Male; Nitrates; Nitric Oxide; Nitrites; Postpartum Period; Pregnancy; Reference Values; Sulfanilamides; Time Factors

1999
Elevation of an endogenous inhibitor of nitric oxide synthase in diabetic rat serum.
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1997, Volume: 18, Issue:6

    Topics: Animals; Aorta; Arginine; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Vasodilation

1997
Hepatocyte growth factor regulates human trophoblast motility and invasion: a role for nitric oxide.
    British journal of pharmacology, 1999, Volume: 128, Issue:1

    Topics: Arginine; Cell Division; Cell Line; Cell Movement; Cell Size; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Induction; Female; Fibrin; Hepatocyte Growth Factor; Humans; Integrins; Interleukin-1; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; RNA, Messenger; Transfection; Trophoblasts; Tumor Necrosis Factor-alpha

1999
Regulation of macrophage nitric oxide synthesis by endothelial cells: a role for NG,NG-dimethylarginine.
    Acta physiologica Scandinavica, 1999, Volume: 167, Issue:2

    Topics: Animals; Arginine; Blotting, Western; Cell Count; Cell Line, Transformed; Cell Transformation, Viral; Cells, Cultured; Coculture Techniques; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III

1999
Amniotic fluid nitric oxide metabolites, cyclic guanosine 3',5' monophosphate and dimethylarginine in alloimmunized pregnancies.
    European journal of obstetrics, gynecology, and reproductive biology, 1999, Volume: 85, Issue:2

    Topics: Amniocentesis; Amniotic Fluid; Arginine; Blood Transfusion, Intrauterine; Creatinine; Cyclic GMP; Embryonic and Fetal Development; Erythroblastosis, Fetal; Female; Gestational Age; Humans; Infant, Newborn; Nitric Oxide; Nitrites; Pregnancy; Reference Values; Regression Analysis; Retrospective Studies; Rh Isoimmunization

1999
[Role of L-arginine--endogenous NOS inhibitors--endothelin-1 pathway for the vascular remodelling].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1999, Volume: 114 Suppl 1

    Topics: Animals; Arginine; Carotid Arteries; Cell Division; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Male; Muscle, Smooth, Vascular; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rabbits; Regeneration

1999
Study on the relationship between plasma nitrite and nitrate level and salt sensitivity in human hypertension : modulation of nitric oxide synthesis by salt intake.
    Circulation, 2000, Feb-29, Volume: 101, Issue:8

    Topics: Adult; Aged; Arginine; Blood Pressure; Electrolytes; Female; Humans; Hypertension; Lipids; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Norepinephrine; Renin; Smoking; Sodium Chloride, Dietary; Vascular Resistance

2000
Is asymmetric dimethylarginine a novel marker of atherosclerosis?
    Circulation, 2000, Apr-11, Volume: 101, Issue:14

    Topics: Arginine; Arteriosclerosis; Biomarkers; Carotid Arteries; Chromatography, High Pressure Liquid; Cyclic GMP; Enzyme Inhibitors; Humans; Nitrates; Nitric Oxide Synthase; Regression Analysis; Stereoisomerism; Tunica Intima

2000
NG, NG-dimethylarginine and NG, NG-dimethylarginine in renal insufficiency.
    Pflugers Archiv : European journal of physiology, 2000, Volume: 439, Issue:5

    Topics: Aged; Aged, 80 and over; Animals; Arginine; Blood Urea Nitrogen; Creatinine; Female; Humans; Isomerism; Male; Mice; Mice, Inbred C57BL; Middle Aged; Nephrectomy; Rats; Rats, Sprague-Dawley; Renal Insufficiency; Species Specificity; Urea

2000
Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans.
    Arteriosclerosis, thrombosis, and vascular biology, 2000, Volume: 20, Issue:4

    Topics: Adult; Animals; Aorta; Arginine; Cattle; Cell Adhesion; Chromatography, High Pressure Liquid; Coculture Techniques; Endothelium, Vascular; Enzyme Inhibitors; Female; Flow Cytometry; Humans; Hypercholesterolemia; Leukocytes, Mononuclear; Male; Matched-Pair Analysis; Middle Aged; Nitric Oxide Synthase

2000
Thyrocyte release of asymmetric dimethylarginine does not account for human thyrocyte inhibition of endothelial cell cyclic GMP.
    European journal of endocrinology, 2000, Volume: 142, Issue:5

    Topics: Arginine; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide Synthase; Radioimmunoassay; Thyroid Gland; Umbilical Veins

2000
Determination of asymmetrical dimethylarginine by capillary electrophoresis-laser-induced fluorescence.
    Journal of chromatography. B, Biomedical sciences and applications, 2000, Apr-28, Volume: 741, Issue:1

    Topics: Arginine; Calibration; Electrophoresis, Capillary; Fluorescence; Humans; Kidney Failure, Chronic; Lasers; Reproducibility of Results; Sensitivity and Specificity

2000
Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia.
    Arteriosclerosis, thrombosis, and vascular biology, 2000, Volume: 20, Issue:6

    Topics: Animals; Arginine; Cell Line, Transformed; Cholesterol; Diet; Dietary Fats; Endothelium, Vascular; Enzyme Inhibitors; Homocysteine; Humans; Hypercholesterolemia; Hyperhomocysteinemia; Macaca fascicularis; Methionine; Nitric Oxide Synthase; Regression Analysis; Vasodilation

2000
Vascular endothelial cell activation associated with increased plasma asymmetric dimethyl arginine in children and young adults with hypertension: a basis for atheroma?
    Blood pressure, 2000, Volume: 9, Issue:1

    Topics: Adolescent; Adult; Arginine; Arteriosclerosis; Child; Child, Preschool; Endothelium, Vascular; Female; Glomerular Filtration Rate; Humans; Hypertension; Infant; Male; Vascular Cell Adhesion Molecule-1

2000
LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases.
    Circulation research, 2000, Jul-21, Volume: 87, Issue:2

    Topics: Arginine; Cell Line; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Humans; Kinetics; Lipoproteins, LDL; Methionine; Nitric Oxide Synthase; Protein-Arginine N-Methyltransferases; S-Adenosylmethionine

2000
Endogenous nitric oxide synthase inhibitors are responsible for the L-arginine paradox.
    FEBS letters, 2000, Jul-28, Volume: 478, Issue:1-2

    Topics: Animals; Arginine; Binding, Competitive; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Meta-Analysis as Topic; Models, Biological; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Thermodynamics

2000
Nitric oxide improves membrane fluidity of erythrocytes in essential hypertension: An electron paramagnetic resonance investigation.
    Biochemical and biophysical research communications, 2000, Sep-07, Volume: 275, Issue:3

    Topics: Arginine; Blood Pressure; Calcimycin; Cell Membrane; Cyclic GMP; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Erythrocytes; Hemorheology; Humans; Hypertension; Membrane Fluidity; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Penicillamine; Spin Labels

2000
Hypercholesterolemia inhibits angiogenesis in response to hindlimb ischemia: nitric oxide-dependent mechanism.
    Circulation, 2000, Nov-07, Volume: 102, Issue:19 Suppl 3

    Topics: Administration, Oral; Animals; Arginine; Body Weight; Cholesterol, Dietary; Collateral Circulation; Cyclic GMP; Endothelium, Vascular; Hindlimb; Hypercholesterolemia; Immunohistochemistry; Ischemia; Laser-Doppler Flowmetry; Lipids; Male; Neovascularization, Physiologic; Nitrates; Nitric Oxide; Nitrites; Rats; Rats, Sprague-Dawley; Regional Blood Flow

2000
Serum concentrations of asymmetric (ADMA) and symmetric (SDMA) dimethylarginine in renal failure patients.
    Kidney international. Supplement, 2001, Volume: 78

    Topics: Adult; Aged; Amino Acids; Arginine; Blood Pressure; Case-Control Studies; Creatinine; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Renal Dialysis

2001
Increased reduction of dimethylarginines and lowered interdialytic blood pressure by the use of biocompatible membranes.
    Kidney international. Supplement, 2001, Volume: 78

    Topics: Adult; Aged; Arginine; beta 2-Microglobulin; Biocompatible Materials; Blood Pressure; Diabetic Nephropathies; Female; Hematocrit; Hemodiafiltration; Hemoglobins; Humans; Kidney Failure, Chronic; Kidneys, Artificial; Male; Membranes, Artificial; Middle Aged; Renal Dialysis; Urea

2001
Comment: the asymmetrical dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in the regulation of nitric oxide generation.
    Clinical science (London, England : 1979), 2001, Volume: 100, Issue:2

    Topics: Amidohydrolases; Arginine; Endothelium, Vascular; Humans; Hydrolases; Hyperhomocysteinemia; Nitric Oxide

2001
Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inaemia in humans.
    Clinical science (London, England : 1979), 2001, Volume: 100, Issue:2

    Topics: Acute Disease; Adult; Arginine; Brachial Artery; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Nitroglycerin; Vasodilation; Vasodilator Agents

2001
Reversible sequestration of nitric oxide by hemoglobin during hemodialysis in end-stage renal disease.
    The American journal of the medical sciences, 2001, Volume: 321, Issue:2

    Topics: Anemia; Arginine; Erythropoietin; Hematocrit; Hemoglobins; Humans; Hypotension; Kidney Failure, Chronic; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Renal Dialysis; Skin Temperature

2001
Circulating endothelial nitric oxide synthase inhibitory factor in some patients with chronic renal disease.
    Kidney international, 2001, Volume: 59, Issue:4

    Topics: Adult; Aged; Arginine; Blood Physiological Phenomena; Blood Urea Nitrogen; Cells, Cultured; Creatinine; Endothelium, Vascular; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Reference Values; Skin

2001
Plasma levels of asymmetrical dimethyl-L-arginine in patients with congenital heart disease and pulmonary hypertension.
    Journal of cardiovascular pharmacology, 2001, Volume: 37, Issue:4

    Topics: Adolescent; Adult; Arginine; Child; Child, Preschool; Enzyme Inhibitors; Heart Defects, Congenital; Hemodynamics; Humans; Hypertension, Pulmonary; Infant; Nitric Oxide Synthase

2001
Methylation of histone H3 by coactivator-associated arginine methyltransferase 1.
    Biochemistry, 2001, May-15, Volume: 40, Issue:19

    Topics: Amino Acid Sequence; Amino Acids; Animals; Arginine; Catalysis; Cattle; Chickens; Chromatography, High Pressure Liquid; Enzyme Activation; Histones; Kinetics; Methylation; Molecular Sequence Data; Oligopeptides; omega-N-Methylarginine; Protein-Arginine N-Methyltransferases; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity

2001
Dimethylarginines in chronic renal failure.
    Journal of clinical pathology, 2001, Volume: 54, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Chromatography, High Pressure Liquid; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis

2001
SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets.
    Molecular cell, 2001, Volume: 7, Issue:5

    Topics: Amino Acid Sequence; Arginine; Autoantigens; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; HeLa Cells; Humans; Methylation; Molecular Sequence Data; Muscular Atrophy, Spinal; Nerve Tissue Proteins; Protein Binding; Recombinant Fusion Proteins; Ribonucleoproteins, Small Nuclear; RNA-Binding Proteins; SMN Complex Proteins; snRNP Core Proteins; Substrate Specificity

2001
Estriol improves membrane fluidity of erythrocytes by the nitric oxide-dependent mechanism: an electron paramagnetic resonance study.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2001, Volume: 24, Issue:3

    Topics: Arginine; Cyclic GMP; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Erythrocyte Membrane; Estriol; Female; Humans; In Vitro Techniques; Male; Membrane Fluidity; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine

2001
PRMT5 (Janus kinase-binding protein 1) catalyzes the formation of symmetric dimethylarginine residues in proteins.
    The Journal of biological chemistry, 2001, Aug-31, Volume: 276, Issue:35

    Topics: Arginine; Binding Sites; HeLa Cells; Humans; Methylation; Models, Molecular; Myelin Basic Protein; Protein Conformation; Protein Methyltransferases; Protein-Arginine N-Methyltransferases; Recombinant Fusion Proteins; Recombinant Proteins; S-Adenosylmethionine

2001
Levels of dimethylarginines and cytokines in mild and severe preeclampsia.
    Acta obstetricia et gynecologica Scandinavica, 2001, Volume: 80, Issue:7

    Topics: Arginine; Blood Pressure; Cytokines; Female; Gestational Age; Humans; Nitric Oxide Synthase; Pre-Eclampsia; Pregnancy; Statistics, Nonparametric; Uric Acid

2001
Mild-to-moderate hypertriglyceridemia in young men is associated with endothelial dysfunction and increased plasma concentrations of asymmetric dimethylarginine.
    Journal of the American College of Cardiology, 2001, Volume: 38, Issue:1

    Topics: Adult; Arginine; Brachial Artery; Carotid Artery, Common; Endothelium, Vascular; Humans; Hypertriglyceridemia; Male; Nitric Oxide Synthase; Ultrasonography, Interventional; Vasodilation

2001
Electron paramagnetic resonance investigation on modulatory effect of 17beta-estradiol on membrane fluidity of erythrocytes in postmenopausal women.
    Arteriosclerosis, thrombosis, and vascular biology, 2001, Volume: 21, Issue:8

    Topics: Aged; Arginine; Cyclic GMP; Electron Spin Resonance Spectroscopy; Erythrocytes; Estradiol; Female; Humans; Hypertension; In Vitro Techniques; Membrane Fluidity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Postmenopause; S-Nitroso-N-Acetylpenicillamine

2001
Elevated serum endogenous inhibitor of nitric oxide synthase and endothelial dysfunction in aged rats.
    Clinical and experimental pharmacology & physiology, 2001, Volume: 28, Issue:10

    Topics: Acetylcholine; Aging; Animals; Aorta, Thoracic; Arginine; Endothelium, Vascular; Kidney; Male; Nitric Oxide Synthase; Nitrites; Rats; Rats, Sprague-Dawley; Vasodilator Agents

2001
Elevated levels of plasma homocyst(e)ine and asymmetric dimethylarginine in elderly patients with stroke.
    Atherosclerosis, 2001, Volume: 158, Issue:2

    Topics: Aged; Aged, 80 and over; Arginine; Cerebral Infarction; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Female; Homocysteine; Humans; Logistic Models; Male; Nitric Oxide Synthase; Recurrence; Risk Factors; Stroke

2001
Reduction in asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in the cerebrospinal fluid during aging and in patients with Alzheimer's disease.
    Neuroscience letters, 2001, Oct-26, Volume: 312, Issue:3

    Topics: Aged; Aging; Alzheimer Disease; Arginine; Brain; Female; Humans; Male; Middle Aged; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress

2001
Effect of asymmetric dimethylarginine on osteoblastic differentiation.
    Kidney international, 2001, Volume: 60, Issue:5

    Topics: Alkaline Phosphatase; Animals; Arginine; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Female; Kidney Failure, Chronic; Mice; Nitric Oxide; Osteoblasts; RNA, Messenger

2001
Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus.
    The American journal of cardiology, 2001, Nov-15, Volume: 88, Issue:10

    Topics: Arginine; Blood Glucose; Case-Control Studies; Cholesterol; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase

2001
The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins.
    Molecular and cellular biology, 2001, Volume: 21, Issue:24

    Topics: Arginine; Blotting, Western; Carrier Proteins; Cell Survival; Cells, Cultured; Cytoplasm; DNA; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epitopes; Glutathione Transferase; Humans; Mass Spectrometry; Methylation; Methyltransferases; Models, Biological; Precipitin Tests; Protein Binding; Protein Methyltransferases; Protein Structure, Tertiary; Protein-Arginine N-Methyltransferases; Recombinant Fusion Proteins; Recombinant Proteins; Sucrose; Transfection

2001
Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine.
    Circulation, 2001, Nov-20, Volume: 104, Issue:21

    Topics: Amidohydrolases; Animals; Aorta; Arginine; Arteriosclerosis; Cattle; Cell Line; Culture Techniques; Endothelium, Vascular; Homocysteine; Hydrolases; Hyperhomocysteinemia; Kinetics; Methionine; Nitric Oxide; Nitric Oxide Synthase; Recombinant Fusion Proteins; Signal Transduction

2001
Marked increase of asymmetric dimethylarginine in patients with incipient primary chronic renal disease.
    Journal of the American Society of Nephrology : JASN, 2002, Volume: 13, Issue:1

    Topics: Adult; Arginine; Creatinine; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Osmolar Concentration; Reference Values; Severity of Illness Index

2002
Endogenous nitric oxide synthase inhibitors in endothelial cells, endothelin-1 within the vessel wall, and intimal hyperplasia in perimenopausal human uterine arteries.
    Journal of cardiovascular pharmacology, 2002, Volume: 39, Issue:2

    Topics: Adult; Arginine; Arteries; Chromatography, High Pressure Liquid; Climacteric; Cyclic GMP; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hyperplasia; In Vitro Techniques; Middle Aged; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Tunica Intima; Tunica Media; Uterus

2002
Asymmetric dimethylarginine, C-reactive protein, and carotid intima-media thickness in end-stage renal disease.
    Journal of the American Society of Nephrology : JASN, 2002, Volume: 13, Issue:2

    Topics: Adult; Aged; Arginine; C-Reactive Protein; Carotid Arteries; Cohort Studies; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic; Male; Middle Aged; Single-Blind Method; Tunica Intima; Tunica Media; Ultrasonography, Doppler, Color

2002
Hemodynamic changes during hemodialysis: role of nitric oxide and endothelin.
    Kidney international, 2002, Volume: 61, Issue:2

    Topics: Adult; Aged; Arginine; Endothelin-1; Female; Humans; Hypertension, Renal; Hypotension; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Renal Dialysis

2002
Probucol preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level.
    British journal of pharmacology, 2002, Volume: 135, Issue:5

    Topics: Animals; Aorta, Thoracic; Arginine; Endothelium, Vascular; Enzyme Inhibitors; Lipoproteins, LDL; Male; Malondialdehyde; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Probucol; Rats; Rats, Sprague-Dawley; Vasodilation

2002
High NaCl intake decreases both flow-induced dilation and pressure-induced myogenic tone in resistance arteries from normotensive rats: involvement of cyclooxygenase-2.
    Pharmacology & toxicology, 2001, Volume: 89, Issue:4

    Topics: Animals; Arginine; Blood Pressure; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Endothelium, Vascular; Indomethacin; Isoenzymes; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred WKY; Regional Blood Flow; Sodium Chloride, Dietary; Sulfonamides; Vasodilation

2001
Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor.
    JAMA, 2002, Mar-20, Volume: 287, Issue:11

    Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Cross-Sectional Studies; Enzyme Inhibitors; Female; Humans; Hypertension; Hypoglycemic Agents; Lipoproteins; Male; Metabolic Diseases; Metabolic Syndrome; Middle Aged; Nitric Oxide Synthase; Regression Analysis; Risk Factors; Rosiglitazone; Thiazoles; Thiazolidinediones; Vasodilator Agents

2002
Insulin resistance, ADMA levels, and cardiovascular disease.
    JAMA, 2002, Mar-20, Volume: 287, Issue:11

    Topics: Arginine; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Insulin Resistance; Metabolic Syndrome; Nitric Oxide Synthase; Risk Factors

2002
Myocardial proteome analysis reveals reduced NOS inhibition and enhanced glycolytic capacity in areas of low local blood flow.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, Volume: 16, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Coronary Circulation; Dogs; Electrophoresis, Gel, Two-Dimensional; Energy Metabolism; Enzyme Inhibitors; Fatty Acids; Glycolysis; Hydrolases; Kinetics; Mass Spectrometry; Models, Cardiovascular; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Proteome

2002
Determination of arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in human plasma and other biological samples by high-performance liquid chromatography.
    Analytical biochemistry, 2002, Apr-15, Volume: 303, Issue:2

    Topics: Arginine; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Humans; In Vitro Techniques; Quality Control

2002
Localization and role of nitric oxide synthase and endogenous nitric oxide synthase inhibitors in the rabbit lower urinary tract.
    The Journal of urology, 2002, Volume: 167, Issue:5

    Topics: Animals; Arginine; Culture Techniques; Enzyme Inhibitors; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rabbits; Urethra; Urinary Bladder

2002
all-trans-Retinoic acid increases nitric oxide synthesis by endothelial cells: a role for the induction of dimethylarginine dimethylaminohydrolase.
    Circulation research, 2002, Apr-19, Volume: 90, Issue:7

    Topics: Amidohydrolases; Arginine; Blotting, Northern; Cell Line; Endothelium, Vascular; Enzyme Induction; Enzyme Inhibitors; Genes, Reporter; Isoenzymes; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Promoter Regions, Genetic; RNA, Messenger; Tretinoin

2002
Helicobacter pylori infection inhibits antral mucosal nitric oxide production in humans.
    Scandinavian journal of gastroenterology, 2002, Volume: 37, Issue:4

    Topics: Adolescent; Adult; Aged; Arginine; Biopsy, Needle; Blotting, Western; Chromatography, High Pressure Liquid; Female; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pyloric Antrum; Up-Regulation

2002
Nitric oxide and angiogenesis.
    Circulation, 2002, May-07, Volume: 105, Issue:18

    Topics: Angiogenesis Inhibitors; Angiostatins; Animals; Arginine; Arteriosclerosis; Coronary Circulation; Dogs; Endothelium, Vascular; Matrix Metalloproteinases; Myocardial Ischemia; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Plasminogen

2002
Accumulated endogenous NOS inhibitors, decreased NOS activity, and impaired cavernosal relaxation with ischemia.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:6

    Topics: Animals; Arginine; Calcium; Carbachol; Cholinergic Agonists; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Endothelium, Vascular; Enzyme Inhibitors; Iliac Artery; Impotence, Vasculogenic; In Vitro Techniques; Ischemia; Male; Nitric Oxide Synthase; omega-N-Methylarginine; Penis; Rabbits; Vasoconstrictor Agents; Vasodilator Agents

2002
Left ventricular hypertrophy, cardiac remodeling and asymmetric dimethylarginine (ADMA) in hemodialysis patients.
    Kidney international, 2002, Volume: 62, Issue:1

    Topics: Adult; Aged; Arginine; Echocardiography; Endothelium, Vascular; Female; Humans; Hypertrophy, Left Ventricular; Kidney Failure, Chronic; Male; Middle Aged; Multivariate Analysis; Nitric Oxide; Renal Dialysis; Vasodilation; Ventricular Dysfunction, Left

2002
Endogenous methylarginines regulate neuronal nitric-oxide synthase and prevent excitotoxic injury.
    The Journal of biological chemistry, 2002, Sep-13, Volume: 277, Issue:37

    Topics: Animals; Arginine; Cell Survival; Cells, Cultured; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; omega-N-Methylarginine; Rats

2002
Effect of age on bone mineral density and the serum concentration of endogenous nitric oxide synthase inhibitors in rats.
    Comparative medicine, 2002, Volume: 52, Issue:3

    Topics: Absorptiometry, Photon; Aging; Animals; Arginine; Bone and Bones; Bone Density; Enzyme Inhibitors; Male; Malondialdehyde; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley

2002
Reduced nitric oxide synthase activity in rats with chronic renal disease due to glomerulonephritis.
    Kidney international, 2002, Volume: 62, Issue:2

    Topics: Animals; Antibodies; Arginine; Autoantibodies; Blood Urea Nitrogen; Creatinine; Glomerulonephritis; Kidney Failure, Chronic; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrites; Proteinuria; Rats; Rats, Sprague-Dawley

2002
Blunted acetylcholine relaxation and nitric oxide release in arteries from renal hypertensive rats.
    Journal of hypertension, 2002, Volume: 20, Issue:8

    Topics: Acetylcholine; Animals; Arginine; Free Radical Scavengers; Hypertension, Renovascular; In Vitro Techniques; Male; Mesenteric Artery, Superior; Nitric Oxide; Nitric Oxide Donors; Oxyhemoglobins; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase; Vasodilation

2002
Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase.
    Circulation, 2002, Aug-20, Volume: 106, Issue:8

    Topics: Amidohydrolases; Animals; Antioxidants; Aorta; Arginine; Cell Line; Cells, Cultured; Cyclic GMP; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Glucose; Humans; Male; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Oxidative Stress; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Superoxide Dismutase

2002
Endothelin stimulates an endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, in experimental heart failure.
    Clinical science (London, England : 1979), 2002, Volume: 103 Suppl 48

    Topics: Animals; Arginine; Cardiac Output; Cardiac Pacing, Artificial; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Heart Failure; Models, Animal; Nitric Oxide Synthase; Pyrimidines; Random Allocation; Receptor, Endothelin A; Sulfonamides; Vascular Resistance

2002
Alzheimer's disease is not associated with altered concentrations of the nitric oxide synthase inhibitor asymmetric dimethylarginine in cerebrospinal fluid.
    Journal of neural transmission (Vienna, Austria : 1996), 2002, Volume: 109, Issue:9

    Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Arginine; Brain; Cytoskeleton; Dimethylamines; Female; Humans; Male; Middle Aged; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Peptide Fragments; tau Proteins

2002
Endothelial damage, asymmetric dimethylarginine and cardiovascular risk in end-stage renal disease.
    Blood purification, 2002, Volume: 20, Issue:5

    Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Kidney Failure, Chronic; Models, Cardiovascular; Risk Factors

2002
Angiotensin-converting enzyme activity is involved in the mechanism of increased endogenous nitric oxide synthase inhibitor in patients with type 2 diabetes mellitus.
    Circulation journal : official journal of the Japanese Circulation Society, 2002, Volume: 66, Issue:9

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Arginine; Cross-Over Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Immunoassay; Male; Nitric Oxide Synthase; Peptidyl-Dipeptidase A; Perindopril; Renin-Angiotensin System; von Willebrand Factor

2002
Homocysteine and ADMA--emerging risk factors for cardiovascular disease?
    Blood pressure, 2002, Volume: 11, Issue:4

    Topics: Arginine; Cardiovascular Diseases; Homocysteine; Humans; Predictive Value of Tests; Risk Factors

2002
Circulating concentrations of asymmetrical dimethyl-L-arginine are increased in women with previous gestational diabetes.
    Diabetologia, 2002, Volume: 45, Issue:10

    Topics: Adult; Arginine; Biomarkers; Body Mass Index; Diabetes, Gestational; Female; Follow-Up Studies; Humans; Postpartum Period; Pregnancy

2002
Plasma asymmetric dimethylarginine and hyperemic myocardial blood flow in young subjects with borderline hypertension or familial hypercholesterolemia.
    Journal of the American College of Cardiology, 2002, Oct-02, Volume: 40, Issue:7

    Topics: Adult; Age Factors; Arginine; Biomarkers; Blood Flow Velocity; Case-Control Studies; Coronary Circulation; Cross-Sectional Studies; Dipyridamole; Humans; Hyperemia; Hyperlipoproteinemia Type II; Hypertension; Linear Models; Male; Multivariate Analysis; Nitric Oxide Synthase; Tomography, Emission-Computed; Vasodilator Agents

2002
Net renal extraction of asymmetrical (ADMA) and symmetrical (SDMA) dimethylarginine in fasting humans.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2002, Volume: 17, Issue:11

    Topics: Aged; Arginine; Arteries; Creatinine; Fasting; Female; Humans; Kidney; Male; Middle Aged; Molecular Conformation; Osmolar Concentration

2002
Hypertension in relation to nitric oxide, asymmetric dimethylarginine, and inflammation: different patterns in heart transplant recipients and individuals with essential hypertension.
    Transplantation, 2002, Nov-27, Volume: 74, Issue:10

    Topics: Arginine; Blood Pressure; Female; Heart Transplantation; Humans; Hypertension; Inflammation; Male; Middle Aged; Nitric Oxide; Tumor Necrosis Factor-alpha

2002
Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in hyperthyroid patients.
    The Journal of clinical endocrinology and metabolism, 2002, Volume: 87, Issue:12

    Topics: Adult; Aged; Arginine; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Osmolar Concentration; Reference Values

2002
Endothelium-dependent vasorelaxation and the expression of calcitonin gene-related peptide in aged rats.
    Neuropeptides, 2002, Volume: 36, Issue:6

    Topics: Aging; Animals; Arginine; Calcitonin Gene-Related Peptide; Endothelium, Vascular; Gene Expression; Male; Phenylephrine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Vasoconstrictor Agents; Vasodilation

2002
Presence of methylated arginine derivatives in orthotopic human liver transplantation: relevance for liver function.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2003, Volume: 9, Issue:1

    Topics: Animals; Arginine; Cells, Cultured; Chromatography, High Pressure Liquid; Female; Hepatocytes; Humans; Liver Transplantation; Male; Middle Aged; Nitric Oxide Synthase; Postoperative Period; Rats; Reperfusion Injury

2003
Reduction of total homocysteine levels by oral folic acid fails to improve endothelial function in children with chronic renal failure.
    Circulation, 2003, Jan-07, Volume: 107, Issue:1

    Topics: Administration, Oral; Arginine; Child; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Kidney Failure, Chronic; Vasodilation

2003
Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, in maternal and fetal circulation.
    Journal of the Society for Gynecologic Investigation, 2003, Volume: 10, Issue:1

    Topics: Adolescent; Adult; Arginine; Enzyme Inhibitors; Female; Fetal Blood; Gestational Age; Humans; Labor, Obstetric; Nitric Oxide Synthase; Pregnancy; Reference Values; Umbilical Veins

2003
The liver is an important organ in the metabolism of asymmetrical dimethylarginine (ADMA).
    Clinical nutrition (Edinburgh, Scotland), 2003, Volume: 22, Issue:1

    Topics: Animals; Arginine; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Kidney; Liver; Liver Circulation; Male; Rats; Rats, Wistar; Regional Blood Flow; Renal Circulation

2003
Asymmetrical dimethylarginine (ADMA) in critically ill patients: high plasma ADMA concentration is an independent risk factor of ICU mortality.
    Clinical nutrition (Edinburgh, Scotland), 2003, Volume: 22, Issue:1

    Topics: Adult; Aged; Analysis of Variance; Arginine; Critical Illness; Cross-Sectional Studies; Enzyme Inhibitors; Female; Humans; Intensive Care Units; Liver Failure; Male; Middle Aged; Multiple Organ Failure; Pilot Projects; Renal Insufficiency; Risk Factors

2003
The asymmetrical dimethylarginine (ADMA)-multiple organ failure hypothesis.
    Clinical nutrition (Edinburgh, Scotland), 2003, Volume: 22, Issue:1

    Topics: Arginine; Critical Illness; Enzyme Inhibitors; Humans; Liver; Multiple Organ Failure; Nitric Oxide

2003
Regulation of cytokine-induced nitric oxide synthesis by asymmetric dimethylarginine: role of dimethylarginine dimethylaminohydrolase.
    Circulation research, 2003, Feb-07, Volume: 92, Issue:2

    Topics: Amidohydrolases; Animals; Arginine; Cells, Cultured; Culture Media, Conditioned; Cytokines; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Interleukin-1; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Transfection

2003
[Relationship between serum asymmetric dimethylarginine and blood pressure in patients with chronic renal failure].
    Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 2002, Apr-28, Volume: 27, Issue:2

    Topics: Adult; Arginine; Chromatography, High Pressure Liquid; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase; Renal Dialysis

2002
Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxia.
    Circulation, 2003, Mar-04, Volume: 107, Issue:8

    Topics: Amidohydrolases; Animals; Animals, Newborn; Arginine; Hypertension, Pulmonary; Hypoxia; Immunohistochemistry; Lung; Male; Pressure; Protein Isoforms; Rats; Rats, Sprague-Dawley; RNA, Messenger; Swine

2003
Plasma concentrations of asymmetric-dimethyl-arginine in type 2 diabetes associate with glycemic control and glomerular filtration rate but not with risk factors of vasculopathy.
    Metabolism: clinical and experimental, 2003, Volume: 52, Issue:3

    Topics: Aged; Arginine; Blood Glucose; Blood Pressure; Cholesterol; Cholesterol, HDL; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Glomerular Filtration Rate; Glycated Hemoglobin; Humans; Insulin; Linear Models; Male; Middle Aged; Risk Factors; Triglycerides

2003
Significance of asymmetric dimethylarginine (ADMA) concentrations during coronary circulation in patients with vasospastic angina.
    Circulation journal : official journal of the Japanese Circulation Society, 2003, Volume: 67, Issue:4

    Topics: Aged; Angina Pectoris; Arginine; Case-Control Studies; Coronary Angiography; Coronary Circulation; Coronary Vasospasm; Coronary Vessels; Enzyme Inhibitors; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Nitrites; Osmolar Concentration; Risk Factors; Vasodilator Agents; Vasomotor System

2003
Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects.
    Circulation, 2003, Apr-15, Volume: 107, Issue:14

    Topics: Adult; Aged; Aging; Arginine; Blood Pressure; Female; Glomerular Filtration Rate; Hemodynamics; Humans; Hypertension; Kidney; Male; Renal Circulation; Renal Plasma Flow, Effective

2003
Oestrogen and the cardiovascular system.
    Clinical science (London, England : 1979), 2003, Volume: 105, Issue:1

    Topics: Arginine; Cardiovascular Physiological Phenomena; Coronary Disease; Endothelium, Vascular; Estrogens, Conjugated (USP); Female; Humans; Lipid Metabolism; Male; Nitric Oxide; Nitric Oxide Synthase; Risk Factors; Selective Estrogen Receptor Modulators

2003
ADMA: a critical cardio-renal link in heart failure?
    European journal of clinical investigation, 2003, Volume: 33, Issue:5

    Topics: Arginine; Heart Failure; Humans; Kidney Failure, Chronic; Nitric Oxide

2003
Endogenous nitric oxide synthase inhibitors and renal perfusion in patients with heart failure.
    European journal of clinical investigation, 2003, Volume: 33, Issue:5

    Topics: Aged; Arginine; Endothelium, Vascular; Heart Failure; Humans; Kidney Diseases; Male; Renal Circulation; Vasodilation

2003
Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia.
    Lancet (London, England), 2003, May-03, Volume: 361, Issue:9368

    Topics: Arginine; Brachial Artery; Endothelium, Vascular; Female; Humans; Placental Circulation; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Ultrasonography, Doppler, Color; Ultrasonography, Prenatal; Uterus; Vasodilation

2003
High-performance liquid chromatographic assay of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine in human plasma by derivatization with naphthalene-2,3-dicarboxaldehyde.
    Analytical biochemistry, 2003, Jul-01, Volume: 318, Issue:1

    Topics: Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Naphthalenes; Reference Standards; Reproducibility of Results; Spectrometry, Fluorescence; Stereoisomerism

2003
Metabolism-based inactivation of neuronal nitric-oxide synthase by components of cigarette and cigarette smoke.
    Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:7

    Topics: Arginine; Calmodulin; Enzyme Inhibitors; NADP; Nicotiana; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Smoke; Solubility; Water

2003
Nitric oxide inhibition as a mechanism for blood pressure increase during salt loading in normotensive postmenopausal women.
    Journal of hypertension, 2003, Volume: 21, Issue:7

    Topics: Arginine; Blood Pressure; Brachial Artery; Endothelium, Vascular; Female; Humans; Middle Aged; Natriuresis; Nitric Oxide; Postmenopause; Predictive Value of Tests; Regression Analysis; Sodium Chloride, Dietary; Vasodilation

2003
Increased asymmetric dimethylarginine and endothelin 1 levels in secondary Raynaud's phenomenon: implications for vascular dysfunction and progression of disease.
    Arthritis and rheumatism, 2003, Volume: 48, Issue:7

    Topics: Adult; Arginine; Brachial Artery; Chemokine CCL2; Cold Temperature; Disease Progression; Endothelin-1; Female; Humans; Laser-Doppler Flowmetry; Male; Microcirculation; Middle Aged; Raynaud Disease; Vascular Cell Adhesion Molecule-1; Vascular Resistance; Vasoconstriction

2003
Elevated levels of the serum endogenous inhibitor of nitric oxide synthase and metabolic control in rats with streptozotocin-induced diabetes.
    Journal of cardiovascular pharmacology, 2003, Volume: 42, Issue:2

    Topics: Animals; Arginine; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Insulin; Male; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley

2003
Dimethylarginine dimethylaminohydrolase activity modulates ADMA levels, VEGF expression, and cell phenotype.
    Biochemical and biophysical research communications, 2003, Sep-05, Volume: 308, Issue:4

    Topics: Amidohydrolases; Arginine; Blotting, Northern; Cells, Cultured; Collagen; Drug Combinations; Endothelial Growth Factors; Endothelium, Vascular; Humans; Immunoblotting; Intercellular Signaling Peptides and Proteins; Laminin; Lymphokines; Phenotype; Plasmids; Proteoglycans; RNA, Messenger; Time Factors; Transfection; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2003
Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension.
    Circulation, 2003, Sep-23, Volume: 108, Issue:12

    Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Chronic Disease; Disease Models, Animal; Enzyme Activation; Hypertension, Pulmonary; Hypoxia; Isoenzymes; Lung; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Rats; Rats, Sprague-Dawley

2003
Estrogen stimulates dimethylarginine dimethylaminohydrolase activity and the metabolism of asymmetric dimethylarginine.
    Circulation, 2003, Sep-30, Volume: 108, Issue:13

    Topics: Amidohydrolases; Arginine; Cardiotonic Agents; Cell Line; Drug Implants; Endothelium, Vascular; Enzyme Activation; Estradiol; Female; Humans; Middle Aged; Postmenopause; Receptors, Estrogen; Tamoxifen

2003
Asymmetrical dimethylarginine and multiple organ failure.
    Clinical nutrition (Edinburgh, Scotland), 2003, Volume: 22, Issue:5

    Topics: Animals; Arginine; Enzyme Inhibitors; Liver; Multiple Organ Failure; Nitric Oxide; Nitric Oxide Synthase; Rats

2003
Elevated plasma and urine levels of ADMA and 15(S)-8-iso-PGF2alpha in end-stage liver disease.
    Hepatology (Baltimore, Md.), 2003, Volume: 38, Issue:4

    Topics: Adult; Aged; Arginine; Dinoprost; F2-Isoprostanes; Female; Humans; Kidney Failure, Chronic; Liver Diseases; Male; Middle Aged

2003
High plasma level of asymmetric dimethylarginine in patients with acutely exacerbated congestive heart failure: role in reduction of plasma nitric oxide level.
    Heart and vessels, 2003, Volume: 18, Issue:4

    Topics: Acute Disease; Arginine; Chromatography, High Pressure Liquid; Chronic Disease; Cytokines; Enzyme Inhibitors; Female; Heart Failure; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Tumor Necrosis Factor-alpha

2003
Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells.
    Hypertension (Dallas, Tex. : 1979), 2003, Volume: 42, Issue:5

    Topics: Amidohydrolases; Arginine; Cell Line, Transformed; Endothelium, Vascular; Gene Expression Regulation; Humans; Microscopy, Fluorescence; NF-kappa B; Protein-Arginine N-Methyltransferases; Stress, Mechanical; Transcription Factor RelA

2003
Asymmetrical dimethylarginine: a novel risk factor for coronary artery disease.
    Clinical cardiology, 2003, Volume: 26, Issue:10

    Topics: Aged; Arginine; Biomarkers; Coronary Angiography; Coronary Artery Disease; Exercise Test; Female; Humans; Male; Multivariate Analysis; Nitric Oxide Synthase; Predictive Value of Tests; Prospective Studies; Risk Factors

2003
When the endothelium cannot say 'NO' anymore. ADMA, an endogenous inhibitor of NO synthase, promotes cardiovascular disease.
    European heart journal, 2003, Volume: 24, Issue:21

    Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Humans; Nitric Oxide; Nitric Oxide Synthase

2003
Plasma levels of asymmetrical dimethylarginine and adverse cardiovascular events after percutaneous coronary intervention.
    European heart journal, 2003, Volume: 24, Issue:21

    Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Coronary Disease; Death, Sudden, Cardiac; Female; Follow-Up Studies; Humans; Male; Multivariate Analysis; Myocardial Infarction; Nitric Oxide Synthase; Prospective Studies; Risk Factors; Survival Analysis

2003
Asymmetric dimethylarginine and total homocysteine in plasma after oral methionine loading.
    Scandinavian journal of clinical and laboratory investigation, 2003, Volume: 63, Issue:5

    Topics: Administration, Oral; Adult; Arginine; Homocysteine; Humans; Male; Methionine; Middle Aged; Time Factors

2003
Handling of asymmetrical dimethylarginine and symmetrical dimethylarginine by the rat kidney under basal conditions and during endotoxaemia.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2003, Volume: 18, Issue:12

    Topics: Animals; Arginine; Biological Transport; Endotoxemia; Enzyme Inhibitors; Kidney; Lipopolysaccharides; Male; Microspheres; Nitric Oxide Synthase; Rats; Rats, Wistar; Renal Circulation

2003
The protective effects of monophosphoryl lipid A on the ischemic myocardium and endothelium in rats.
    Cardiovascular drugs and therapy, 2003, Volume: 17, Issue:4

    Topics: Animals; Arginine; Cholesterol, LDL; Creatine Kinase; Endothelium, Vascular; Heart; Lipid A; Male; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Vasodilation

2003
Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease.
    Kidney international, 2003, Volume: 64, Issue:6

    Topics: Aged; Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Mitochondrial Proton-Translocating ATPases; Oxidative Phosphorylation Coupling Factors; Radioimmunoassay; Risk Factors

2003
Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence.
    Circulation, 2003, Dec-16, Volume: 108, Issue:24

    Topics: Amidohydrolases; Animals; Arginine; Cells, Cultured; Endothelium; Hemodynamics; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Nitric Oxide Synthase; Transfection

2003
Asymmetric dimethylarginine (ADMA): a key regulator of nitric oxide synthase.
    Atherosclerosis. Supplements, 2003, Volume: 4, Issue:4

    Topics: Arginine; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Homeostasis; Humans; Hyperhomocysteinemia; Hyperlipidemias; Nitric Oxide Synthase; Vasodilation

2003
Cytomegalovirus infection impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine in transplant arteriosclerosis.
    Circulation, 2004, Feb-03, Volume: 109, Issue:4

    Topics: Amidohydrolases; Arginine; Cardiovascular Diseases; Cells, Cultured; Coronary Angiography; Coronary Artery Disease; Cyclic GMP; Cytomegalovirus Infections; Endothelium, Vascular; Female; Heart Transplantation; Humans; Male; Middle Aged; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Risk Factors; Signal Transduction

2004
Analysis of the relationship between norepinephrine and asymmetric dimethyl arginine levels among patients with end-stage renal disease.
    Journal of the American Society of Nephrology : JASN, 2004, Volume: 15, Issue:2

    Topics: Arginine; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic; Male; Middle Aged; Norepinephrine; Survival Analysis; Time Factors

2004
Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction.
    Stroke, 2004, Volume: 35, Issue:2

    Topics: Arginine; Cerebrovascular Circulation; DNA Methylation; Homocysteine; Humans; Hyperhomocysteinemia; Oxidative Stress; Reactive Oxygen Species; Risk Factors; Stroke

2004
Asymmetric dimethylarginine and circulatory disorders in postmenopausal women.
    Circulation, 2004, Feb-10, Volume: 109, Issue:5

    Topics: Aged; Arginine; Endothelium, Vascular; Estrogen Replacement Therapy; Female; Humans; Middle Aged; Peripheral Vascular Diseases; Postmenopause; Vasodilation

2004
Plasma concentrations of asymmetric dimethylarginine (ADMA) in Colombian women with pre-eclampsia.
    JAMA, 2004, Feb-18, Volume: 291, Issue:7

    Topics: Adult; Arginine; Case-Control Studies; Colombia; Female; Humans; Pre-Eclampsia; Pregnancy

2004
Upregulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in endothelial cells by nitric oxide deficiency.
    American journal of physiology. Renal physiology, 2004, Volume: 287, Issue:1

    Topics: Arginine; Arteriosclerosis; Blotting, Western; Cell Culture Techniques; Endothelial Cells; Enzyme Inhibitors; Gene Expression Regulation; Humans; Kidney Failure, Chronic; Lipid Metabolism; Nitric Oxide; Nitric Oxide Synthase; Receptors, LDL; Receptors, Oxidized LDL; Reverse Transcriptase Polymerase Chain Reaction; Scavenger Receptors, Class E; Up-Regulation

2004
Asymmetric dimethylarginine upregulates LOX-1 in activated macrophages: role in foam cell formation.
    American journal of physiology. Heart and circulatory physiology, 2004, Volume: 287, Issue:2

    Topics: Arginine; Cell Differentiation; Endothelium, Vascular; Enzyme Inhibitors; Foam Cells; Free Radical Scavengers; HL-60 Cells; Humans; Lipoproteins, LDL; Macrophages; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Receptors, Cell Surface; Receptors, LDL; RNA, Small Interfering; Umbilical Veins; Up-Regulation

2004
Estrogen and asymmetric dimethylarginine in postmenopausal women.
    Circulation, 2004, Mar-30, Volume: 109, Issue:12

    Topics: Amidohydrolases; Arginine; Endothelium, Vascular; Erythrocyte Membrane; Estradiol; Estrogen Replacement Therapy; Female; Hemodynamics; Humans; Membrane Fluidity; Middle Aged; Nitric Oxide; Postmenopause

2004
Changes in the dimeric state of neuronal nitric oxide synthase affect the kinetics of secretagogue-induced insulin response.
    Diabetes, 2004, Volume: 53, Issue:6

    Topics: Animals; Arginine; Carrier Proteins; Cell Line; Dimerization; Drosophila Proteins; Dyneins; Enzyme Inhibitors; Glucose; Indazoles; Insulin; Insulin Secretion; Kinetics; Male; Miconazole; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroarginine; Nitroprusside; Rats; Rats, Wistar; Surface Plasmon Resonance

2004
Homocysteine induces oxidative stress by uncoupling of NO synthase activity through reduction of tetrahydrobiopterin.
    Free radical biology & medicine, 2004, Jun-15, Volume: 36, Issue:12

    Topics: Antioxidants; Arginine; Ascorbic Acid; Biopterins; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Ethidium; Fluorescent Dyes; Homocysteine; Humans; L-Lactate Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Pterins; Reactive Nitrogen Species; Superoxides; Thrombin; Time Factors

2004
Homocysteine, vitamin B6, and endothelial dysfunction in circulatory disorders.
    Stroke, 2004, Volume: 35, Issue:8

    Topics: Arginine; C-Reactive Protein; Endothelium, Vascular; Homocysteine; Humans; Nitric Oxide; Pyridoxal Phosphate; Stroke; Vitamin B 6; Vitamin B 6 Deficiency

2004
Involvement of increased arginase activity in impaired cavernous relaxation with aging in the rabbit.
    The Journal of urology, 2004, Volume: 172, Issue:1

    Topics: Aging; Animals; Arginase; Arginine; Carbachol; Cholinergic Agonists; Endothelium, Vascular; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; omega-N-Methylarginine; Penis; Rabbits

2004
Effects of concentrated fine ambient particles on rat plasma levels of asymmetric dimethylarginine.
    Inhalation toxicology, 2004, Volume: 16, Issue:6-7

    Topics: Air Pollutants; Animals; Arginine; Atmosphere Exposure Chambers; Inhalation Exposure; Male; Meteorological Concepts; Nitric Oxide Synthase; Particle Size; Pilot Projects; Rats; Rats, Inbred BN

2004
Effect of simvastatin on endothelium-dependent vaso-relaxation and endogenous nitric oxide synthase inhibitor.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:7

    Topics: Animals; Arginine; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Humans; Lipoproteins, LDL; Male; Monocytes; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Simvastatin; Tumor Necrosis Factor-alpha; Umbilical Cord; Vasodilation

2004
Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice: involvement of renin-angiotensin system and oxidative stress.
    Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:9

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Coronary Disease; Enzyme Induction; Homocysteine; Imidazoles; Infusion Pumps, Implantable; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcirculation; Myocardium; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Olmesartan Medoxomil; omega-N-Methylarginine; Oxidative Stress; Peptidyl-Dipeptidase A; Renin-Angiotensin System; Superoxides; Tetrazoles; Thiazepines

2004
Cardiovascular effects of asymmetric dimethylarginine.
    Circulation, 2004, Jun-29, Volume: 109, Issue:25

    Topics: Amidohydrolases; Animals; Arginine; Double-Blind Method; Guinea Pigs; Hemodynamics; Humans; Randomized Controlled Trials as Topic

2004
Plasma concentrations of nitric oxide and asymmetric dimethylarginine in human alcoholic cirrhosis.
    Journal of hepatology, 2004, Volume: 41, Issue:1

    Topics: Arginine; Endothelium, Vascular; Female; Humans; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Vasodilation

2004
17beta-estradiol preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level.
    International journal of cardiology, 2004, Volume: 96, Issue:2

    Topics: Analysis of Variance; Animals; Aorta, Thoracic; Arginine; Cholesterol, LDL; Disease Models, Animal; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Estradiol; Male; Malondialdehyde; Nitric Oxide Synthase; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity

2004
Sex hormones and asymmetric dimethylarginine in transplant arteriosclerosis.
    Circulation, 2004, Jul-20, Volume: 110, Issue:3

    Topics: Arginine; Coronary Artery Disease; Endothelium, Vascular; Estrogens; Female; Gonadal Steroid Hormones; Heart Transplantation; Humans; Male

2004
Serum homocysteine and endothelial dysfunction in circulatory disorders in women.
    Circulation, 2004, Jul-27, Volume: 110, Issue:4

    Topics: Arginine; Coronary Disease; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Middle Aged; Myocardial Infarction; Nitric Oxide; Risk; Risk Factors

2004
Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence.
    Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:10

    Topics: Allantoin; Amidohydrolases; Arginine; Cells, Cultured; Cellular Senescence; Chemokine CCL2; Endothelial Cells; Enzyme Inhibitors; Flow Cytometry; Humans; Immunophenotyping; Interleukin-8; Nitric Oxide Synthase; Oxidative Stress; S-Adenosylhomocysteine; Telomerase; Umbilical Veins

2004
Vascular endothelium is the organ chiefly responsible for the catabolism of plasma asymmetric dimethylarginine--an explanation for the elevation of plasma ADMA in disorders characterized by endothelial dysfunction.
    Medical hypotheses, 2004, Volume: 63, Issue:4

    Topics: Amidohydrolases; Arginine; Biomarkers; Catalysis; Clinical Trials as Topic; Endothelium, Vascular; Evidence-Based Medicine; Humans; Models, Cardiovascular; Oxidative Stress; Vascular Diseases

2004
Hypercholesterolemia impairs basal nitric oxide synthase turnover rate: a study investigating the conversion of L-[guanidino-(15)N(2)]-arginine to (15)N-labeled nitrate by gas chromatography--mass spectrometry.
    Nitric oxide : biology and chemistry, 2004, Volume: 11, Issue:1

    Topics: Animals; Arginine; Cholesterol; Cholesterol, Dietary; Diet, Atherogenic; Endothelium, Vascular; Gas Chromatography-Mass Spectrometry; Hypercholesterolemia; Indicator Dilution Techniques; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrogen Isotopes; Rabbits

2004
Plasma asymmetric dimethylarginine and coronary and peripheral endothelial dysfunction in hypertensive patients.
    American journal of hypertension, 2004, Volume: 17, Issue:9

    Topics: Aged; Arginine; Coronary Circulation; Echocardiography, Doppler; Endothelium, Vascular; Female; Forearm; Humans; Hypertension; Hypertrophy, Left Ventricular; Insulin Resistance; Male; Middle Aged

2004
Atherosclerosis and uremic retention solutes.
    Kidney international, 2004, Volume: 66, Issue:4

    Topics: Arginine; Arteriosclerosis; Female; Glomerulosclerosis, Focal Segmental; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Middle Aged; Nitric Oxide; Oxidative Stress; Phosphates; Uremia

2004
Determination of arginine and asymmetric dimethylarginine (ADMA) in human plasma by liquid chromatography/mass spectrometry with the isotope dilution technique.
    Journal of mass spectrometry : JMS, 2004, Volume: 39, Issue:11

    Topics: Adult; Aged; Arginine; Calibration; Carbon Isotopes; Chromatography, Liquid; Citrulline; Female; Humans; Indicator Dilution Techniques; Kidney Failure, Chronic; Male; Mass Spectrometry; Middle Aged; Plasma; Sensitivity and Specificity

2004
Endothelial dysfunction in patients with peripheral arterial disease and chronic hyperhomocysteinemia: potential role of ADMA.
    Vascular medicine (London, England), 2004, Volume: 9, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Arterial Occlusive Diseases; Chronic Disease; Endothelium, Vascular; Enzyme Inhibitors; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Nitric Oxide Synthase; Peripheral Vascular Diseases; Radial Artery; Ultrasonography; Vasodilation

2004
Association between cerebrospinal fluid levels of asymmetric dimethyl-L-arginine, an endogenous inhibitor of endothelial nitric oxide synthase, and cerebral vasospasm in a primate model of subarachnoid hemorrhage.
    Journal of neurosurgery, 2004, Volume: 101, Issue:5

    Topics: Animals; Arginine; Disease Models, Animal; Enzyme Inhibitors; Macaca fascicularis; Middle Cerebral Artery; Nitric Oxide; Nitric Oxide Synthase; Subarachnoid Hemorrhage; Time Factors; Vasospasm, Intracranial

2004
The transplanted liver graft is capable of clearing asymmetric dimethylarginine.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2004, Volume: 10, Issue:12

    Topics: Acute Disease; Arginine; Biomarkers; Case-Control Studies; Chronic Disease; Graft Rejection; Humans; Kidney; Liver; Liver Failure; Liver Transplantation; Osmolar Concentration; Postoperative Period; Prospective Studies

2004
Relationship between obesity, smoking, and the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine.
    Metabolism: clinical and experimental, 2004, Volume: 53, Issue:12

    Topics: Aged; Arginine; Arteriosclerosis; Coronary Disease; Cross-Sectional Studies; Enzyme Inhibitors; Humans; Insulin Resistance; Male; Metabolic Diseases; Middle Aged; Nitric Oxide Synthase; Obesity; Risk Factors; Smoking

2004
Relationship of asymmetric dimethylarginine to haemodialysis hypotension.
    Nitric oxide : biology and chemistry, 2004, Volume: 11, Issue:3

    Topics: Aged; Arginine; Female; Humans; Hypotension; Male; Nitrates; Nitrites; Renal Dialysis; Tumor Necrosis Factor-alpha

2004
Aspirin protected against endothelial damage induced by LDL: role of endogenous NO synthase inhibitors in rats.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:12

    Topics: Amidohydrolases; Animals; Aorta, Thoracic; Arginine; Aspirin; Dose-Response Relationship, Drug; Endothelium, Vascular; Intercellular Adhesion Molecule-1; Lipoproteins, LDL; Male; Malondialdehyde; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha

2004
Determination of asymmetric dimethylarginine (ADMA) using a novel ELISA assay.
    Clinical chemistry and laboratory medicine, 2004, Volume: 42, Issue:12

    Topics: Animals; Arginine; Cells, Cultured; Coronary Vessels; Culture Media, Conditioned; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Humans; Linear Models; Mice; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase; Rats; Sensitivity and Specificity

2004
Weight loss reduces circulating asymmetrical dimethylarginine concentrations in morbidly obese women.
    The Journal of clinical endocrinology and metabolism, 2004, Volume: 89, Issue:12

    Topics: Adult; Arginine; Body Mass Index; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Gastroplasty; Humans; Middle Aged; Obesity, Morbid; Osmolar Concentration; Weight Loss

2004
Plasma levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell disease.
    Annals of hematology, 2005, Volume: 84, Issue:5

    Topics: Adult; Anemia, Sickle Cell; Arginine; Female; Hemoglobin, Sickle; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Vascular Cell Adhesion Molecule-1

2005
A calcium channel blocker, benidipine, improves cell membrane fluidity in human subjects via a nitric oxide-dependent mechanism. An electron paramagnetic resonance investigation.
    American journal of hypertension, 2004, Volume: 17, Issue:12 Pt 1

    Topics: Aged; Arginine; Calcium Channel Blockers; Cell Membrane; Cyclic GMP; Dihydropyridines; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Erythrocytes; Female; Hemorheology; Humans; Male; Membrane Fluidity; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Viscosity

2004
Capillary electrophoretic and micellar electrokinetic separations of asymmetric dimethyl-L-arginine and structurally related amino acids: quantitation in human plasma.
    Journal of separation science, 2004, Volume: 27, Issue:17-18

    Topics: 4-Chloro-7-nitrobenzofurazan; Arginine; Chromatography, Micellar Electrokinetic Capillary; Electrophoresis, Capillary; Humans

2004
A reduction of endogenous asymmetric dimethylarginine contributes to the effect of captopril on endothelial dysfunction induced by homocysteine in rats.
    European journal of pharmacology, 2005, Jan-31, Volume: 508, Issue:1-3

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Captopril; Creatinine; Dose-Response Relationship, Drug; Endothelium, Vascular; Homocysteine; In Vitro Techniques; Liver; Male; Malondialdehyde; Nitrates; Nitric Oxide Synthase; Nitrites; Peptidyl-Dipeptidase A; Phenylephrine; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Vasoconstriction; Vasodilator Agents

2005
Erythropoietin increases asymmetric dimethylarginine in endothelial cells: role of dimethylarginine dimethylaminohydrolase.
    Journal of the American Society of Nephrology : JASN, 2005, Volume: 16, Issue:4

    Topics: Amidohydrolases; Antioxidants; Arginine; Cells, Cultured; Darbepoetin alfa; Endothelial Cells; Erythropoietin; Humans; Intracellular Membranes; Nitric Oxide; Oxidative Stress; Pyrrolidines; Recombinant Proteins; Thiocarbamates

2005
Circulating ADMA concentrations are elevated in hypopituitary adults with and without growth hormone deficiency.
    European journal of clinical investigation, 2005, Volume: 35, Issue:3

    Topics: Arginine; Enzyme Inhibitors; Female; Human Growth Hormone; Humans; Hypopituitarism; Male; Middle Aged; Nitric Oxide Synthase

2005
A new method for the liquid chromatography analysis of methylated arginines in biological fluids and tissues by o-phthaldialdehyde postcolumn derivatization.
    Analytical biochemistry, 2005, Mar-15, Volume: 338, Issue:2

    Topics: Arginine; Chromatography, High Pressure Liquid; Humans; o-Phthalaldehyde; Online Systems

2005
Hyperglycemia, asymmetric dimethylarginine, and patient survival: Dysregulation of complex networks and the metabolic basis of disease.
    Critical care medicine, 2005, Volume: 33, Issue:3

    Topics: Arginine; Critical Illness; Homocysteine; Humans; Insulin; Nitric Oxide Synthase; Signal Transduction; Survival Rate

2005
Plasma asymmetric dimethylarginine concentrations in newly diagnosed patients with acute myocardial infarction or unstable angina pectoris during two weeks of medical treatment.
    The American journal of cardiology, 2005, Mar-15, Volume: 95, Issue:6

    Topics: Adult; Aged; alpha-Tocopherol; Angina, Unstable; Angioplasty, Balloon, Coronary; Arginine; C-Reactive Protein; Cardiovascular Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Combined Modality Therapy; Coronary Angiography; Coronary Artery Disease; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Insulin; Lipoproteins, HDL; Male; Middle Aged; Myocardial Infarction; Statistics as Topic; Treatment Outcome; Triglycerides

2005
Acute hyperhomocysteinemia decreases NO bioavailability in healthy adults.
    Atherosclerosis, 2005, Volume: 179, Issue:2

    Topics: Acute Disease; Animals; Arginine; Biological Availability; Enzyme Inhibitors; Haplorhini; Humans; Hyperhomocysteinemia; Methionine; Nitric Oxide; Oxidative Stress; Reproducibility of Results

2005
Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis.
    Circulation, 2005, Mar-22, Volume: 111, Issue:11

    Topics: Amidohydrolases; Animals; Arginine; Enzyme Induction; Female; Hindlimb; Humans; Ischemia; Laser-Doppler Flowmetry; Mice; Mice, Transgenic; Microspheres; Muscle, Skeletal; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Prostheses and Implants; Recombinant Fusion Proteins

2005
Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:9

    Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Humans; Hypertension, Pulmonary; Isoenzymes; Lung; Male; Monocrotaline; Nitric Oxide; Rats; Rats, Sprague-Dawley

2005
Increased circulating concentrations of asymmetric dimethylarginine (ADMA) in white coat hypertension.
    Journal of human hypertension, 2005, Volume: 19, Issue:8

    Topics: Adult; Arginine; Blood Pressure Monitoring, Ambulatory; Case-Control Studies; Endothelium, Vascular; Female; Humans; Hypertension; Male; Middle Aged; Nitric Oxide; Office Visits

2005
Asymmetrical dimethylarginine plasma concentrations are related to basal nitric oxide release but not endothelium-dependent vasodilation of resistance arteries in peritoneal dialysis patients.
    Journal of the American Society of Nephrology : JASN, 2005, Volume: 16, Issue:6

    Topics: Arginine; Arteries; Endothelium, Vascular; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Peritoneal Dialysis; Vascular Resistance; Vasodilation

2005
Asymmetrical dimethylarginine in idiopathic pulmonary arterial hypertension.
    Arteriosclerosis, thrombosis, and vascular biology, 2005, Volume: 25, Issue:7

    Topics: Adult; Arginine; Biomarkers; Cardiac Catheterization; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Male; Middle Aged; Nitric Oxide Synthase Type III; Pulmonary Circulation; Stroke Volume; Survival Analysis; Vascular Resistance

2005
Effect of diabetic duration on serum concentrations of endogenous inhibitor of nitric oxide synthase in patients and rats with diabetes.
    Life sciences, 2005, May-27, Volume: 77, Issue:2

    Topics: Adult; Aged; Animals; Arginine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Streptozocin; Time Factors; Vasoconstriction

2005
Prognostic value of combined use of biomarkers of inflammation, endothelial dysfunction, and myocardiopathy in patients with ESRD.
    Kidney international, 2005, Volume: 67, Issue:6

    Topics: Adult; Aged; Arginine; Arteriosclerosis; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Endothelium, Vascular; Female; Heart Failure; Humans; Kidney Failure, Chronic; Male; Middle Aged; Natriuretic Peptide, Brain; Prognosis

2005
ADMA regulates angiogenesis: genetic and metabolic evidence.
    Vascular medicine (London, England), 2005, Volume: 10, Issue:1

    Topics: Animals; Arginine; Blotting, Western; Disease Models, Animal; Female; Hypercholesterolemia; Ischemia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neovascularization, Physiologic; Nitric Oxide Synthase

2005
Asymmetric dimethylarginine and progression of chronic kidney disease: the mild to moderate kidney disease study.
    Journal of the American Society of Nephrology : JASN, 2005, Volume: 16, Issue:8

    Topics: Adult; Arginine; Creatinine; Disease Progression; Female; Glomerular Filtration Rate; Hemoglobins; Humans; Kidney; Kidney Diseases; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Parathyroid Hormone; Proportional Hazards Models; Renal Insufficiency; Treatment Outcome

2005
Relations between plasma asymmetric dimethylarginine (ADMA) and risk factors for coronary disease.
    Atherosclerosis, 2006, Volume: 184, Issue:2

    Topics: Adult; Aged; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Coronary Angiography; Coronary Disease; Disease Progression; Female; Follow-Up Studies; Glomerular Filtration Rate; Homocysteine; Humans; Male; Middle Aged; Nitric Oxide Synthase; Prognosis; Retrospective Studies; Risk Factors; Smoking

2006
Asymmetrical dimethylarginine predicts progression to dialysis and death in patients with chronic kidney disease: a competing risks modeling approach.
    Journal of the American Society of Nephrology : JASN, 2005, Volume: 16, Issue:8

    Topics: Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular System; Cohort Studies; Dialysis; Disease Progression; Enzyme Inhibitors; Follow-Up Studies; Glomerular Filtration Rate; Hemoglobins; Homocysteine; Humans; Inflammation; Kidney Failure, Chronic; Middle Aged; Models, Statistical; Models, Theoretical; Proportional Hazards Models; Proteinuria; Regression Analysis; Risk; Risk Factors; Time Factors; Treatment Outcome

2005
Liquid chromatography-tandem mass spectrometry method for the analysis of asymmetric dimethylarginine in human plasma.
    Clinical chemistry, 2005, Volume: 51, Issue:7

    Topics: Arginine; Chromatography, High Pressure Liquid; Humans; Reference Values; Spectrometry, Mass, Electrospray Ionization

2005
Asymmetric dimethylarginine and kidney disease--marker or mediator?
    Journal of the American Society of Nephrology : JASN, 2005, Volume: 16, Issue:8

    Topics: Animals; Arginine; Biomarkers; Humans; Kidney; Kidney Diseases; Nitric Oxide; Renal Insufficiency; Risk

2005
Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase.
    Journal of medicinal chemistry, 2005, Jul-14, Volume: 48, Issue:14

    Topics: Amidohydrolases; Animals; Arginine; Cell Line; Cell Survival; In Vitro Techniques; Kidney; Male; Nitric Oxide Synthase; Rats; Rats, Inbred WKY; Structure-Activity Relationship

2005
Endothelial dysfunction induced by postprandial lipemia is neutralized by addition of proteins to the fatty meal.
    Atherosclerosis, 2006, Volume: 185, Issue:2

    Topics: Adult; Arginine; Blood Flow Velocity; Brachial Artery; Caseins; Dietary Fats; Dietary Proteins; Endothelium, Vascular; Fatty Acids, Nonesterified; Female; Humans; Insulin; Lipids; Male; Postprandial Period; Soybean Proteins; Triglycerides; Ultrasonography; Vasodilation

2006
Asymmetric dimethyl arginine levels correlate with cardiovascular risk factors in patients with erectile dysfunction.
    Atherosclerosis, 2006, Volume: 185, Issue:2

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Arginine; Blood Pressure; C-Reactive Protein; Cardiovascular Diseases; Cholesterol, LDL; E-Selectin; Enzyme Inhibitors; Erectile Dysfunction; Humans; Male; Middle Aged; Nitric Oxide Synthase; Piperazines; Purines; Risk Factors; Sildenafil Citrate; Sulfones

2006
Asymmetric dimethylarginine, L-arginine, and endothelial dysfunction in essential hypertension.
    Journal of the American College of Cardiology, 2005, Aug-02, Volume: 46, Issue:3

    Topics: Acetylcholine; Arginine; Blood Pressure Determination; Case-Control Studies; Chromatography, High Pressure Liquid; Endothelium, Vascular; Female; Humans; Hypertension; Infusions, Intra-Arterial; Male; Nitroprusside; Probability; Reference Values; Sensitivity and Specificity; Severity of Illness Index

2005
Asymmetric dimethylarginine (ADMA) as a risk marker for stroke and TIA in a Swedish population.
    Atherosclerosis, 2006, Volume: 185, Issue:2

    Topics: Acute Disease; Aged; Arginine; Biomarkers; Cerebral Hemorrhage; Cerebral Infarction; Enzyme Inhibitors; Female; Glycated Hemoglobin; Humans; Ischemic Attack, Transient; Male; Multivariate Analysis; Nitric Oxide Synthase; Odds Ratio; Risk Factors; Stroke

2006
The effects of thyroxine replacement on the levels of serum asymmetric dimethylarginine (ADMA) and other biochemical cardiovascular risk markers in patients with subclinical hypothyroidism.
    Clinical endocrinology, 2005, Volume: 63, Issue:2

    Topics: Adolescent; Adult; Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Cholesterol; Enzyme Inhibitors; Female; Homocysteine; Hormone Replacement Therapy; Humans; Hypothyroidism; Lipoproteins, HDL; Lipoproteins, LDL; Middle Aged; Nitric Oxide; Risk Factors; Thyrotropin; Thyroxine; Triiodothyronine

2005
Pioglitazone lowers systemic asymmetric dimethylarginine by inducing dimethylarginine dimethylaminohydrolase in rats.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2005, Volume: 28, Issue:3

    Topics: Amidohydrolases; Animals; Arginine; Cell Line; Dogs; Enzyme Induction; Gene Expression Regulation, Enzymologic; Homocysteine; Hypoglycemic Agents; Kidney Tubules; Male; Nitric Oxide; Pioglitazone; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Sodium; Thiazolidinediones; Up-Regulation

2005
Asymmetric dimethylarginine and the risk of cardiovascular events and death in patients with coronary artery disease: results from the AtheroGene Study.
    Circulation research, 2005, Sep-02, Volume: 97, Issue:5

    Topics: Adult; Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Coronary Disease; Creatinine; Female; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Prospective Studies; Risk Factors

2005
Raised plasma levels of asymmetric dimethylarginine are associated with cardiovascular events, disease activity, and organ damage in patients with systemic lupus erythematosus.
    Annals of the rheumatic diseases, 2005, Volume: 64, Issue:9

    Topics: Adult; Arginine; Biomarkers; Cardiovascular Diseases; Female; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Nitric Oxide Synthase; Regression Analysis; Risk Factors; Severity of Illness Index

2005
Systemic nitric oxide production rate during hemodialysis and its relationship with nitric oxide-related factors.
    Blood purification, 2005, Volume: 23, Issue:4

    Topics: Arginine; Biopterins; Blood Pressure; Female; Humans; Lipoproteins, LDL; Male; Middle Aged; Nitrates; Nitric Oxide; Renal Dialysis

2005
Asymmetric dimethylarginine: a molecule responsible for the coexistence of insulin resistance and atherosclerosis via dual nitric oxide synthase inhibition.
    Medical hypotheses, 2005, Volume: 65, Issue:6

    Topics: Animals; Arginine; Atherosclerosis; Biomarkers; Enzyme Inhibitors; Evidence-Based Medicine; Humans; Insulin Resistance; Models, Biological; Nitric Oxide; Nitric Oxide Synthase

2005
Dimethylarginine dimethylaminohydrolase overexpression suppresses graft coronary artery disease.
    Circulation, 2005, Sep-13, Volume: 112, Issue:11

    Topics: Amidohydrolases; Animals; Arginine; Coronary Artery Disease; Cytokines; Enzyme Inhibitors; Female; Heart; Heart Transplantation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocarditis; Myocardium; Nitrates; Nitric Oxide Synthase; Nitrites; Osmolar Concentration; Postoperative Period; Pregnancy; Superoxides; Time Factors; Transplantation, Heterotopic; Transplantation, Homologous; Tumor Necrosis Factor-alpha

2005
The GLU298ASP variant of nitric oxide synthase interacts with asymmetric dimethyl arginine in determining cardiovascular mortality in patients with end-stage renal disease.
    Journal of hypertension, 2005, Volume: 23, Issue:10

    Topics: Adult; Aged; Amino Acid Substitution; Analysis of Variance; Arginine; Aspartic Acid; Cardiovascular Diseases; Female; Gene Frequency; Genotype; Glutamic Acid; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase; Polymorphism, Genetic; Regression Analysis; Survival Rate

2005
Determination of a reference value for N(G), N(G)-dimethyl-L-arginine in 500 subjects.
    European journal of clinical investigation, 2005, Volume: 35, Issue:10

    Topics: Adult; Aged; Aging; Arginine; Biomarkers; Cardiovascular Diseases; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Reference Values; Sensitivity and Specificity; Sex Characteristics

2005
An association between plasma asymmetric dimethylarginine and membrane fluidity of erythrocytes in hypertensive and normotensive men: an electron paramagnetic resonance investigation.
    American journal of hypertension, 2005, Volume: 18, Issue:9 Pt 1

    Topics: Arginine; Electron Spin Resonance Spectroscopy; Erythrocyte Membrane; Humans; Hypertension; Male; Membrane Fluidity; Middle Aged; Nitrates; Nitrites

2005
Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA.
    PLoS medicine, 2005, Volume: 2, Issue:10

    Topics: Arginine; Atherosclerosis; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins; Cardiovascular Diseases; Cell Culture Techniques; Endothelial Cells; Gene Expression Profiling; Gene Expression Regulation; Humans; Hypertension, Pulmonary; Oligonucleotide Array Sequence Analysis; Protein-Arginine N-Methyltransferases; Smad5 Protein; Transforming Growth Factor beta

2005
Concentrations of homocysteine, related metabolites and asymmetric dimethylarginine in preeclamptic women with poor nutritional status.
    Clinical chemistry and laboratory medicine, 2005, Volume: 43, Issue:10

    Topics: Adult; Arginine; Female; Homocysteine; Humans; Nutritional Status; Pre-Eclampsia; Pregnancy; Time Factors; Vitamins

2005
Asymmetric dimethylarginine, homocysteine and renal function--is there a relation?
    Clinical chemistry and laboratory medicine, 2005, Volume: 43, Issue:10

    Topics: Adult; Age Factors; Arginine; Female; Homocysteine; Humans; Hyperhomocysteinemia; Kidney; Kidney Function Tests; Male; Middle Aged; Renal Dialysis

2005
Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation.
    Arteriosclerosis, thrombosis, and vascular biology, 2005, Volume: 25, Issue:12

    Topics: Animals; Antioxidants; Aorta, Thoracic; Arginine; Biopterins; Cells, Cultured; Cystathionine beta-Synthase; Endothelium, Vascular; Enzyme Activation; Female; Gene Expression Regulation, Enzymologic; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Homocysteine; Humans; Hyperhomocysteinemia; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Kinase C; Pterins; Superoxide Dismutase; Vasodilation

2005
[ADMA (asymmetric dimethylarginine)--the inhibitor of nitric oxide (NO) synthesis: a new marker for vascular pathology].
    Harefuah, 2005, Volume: 144, Issue:9

    Topics: Arginine; Biomarkers; Humans; Nitric Oxide; Nitric Oxide Synthase; Vascular Diseases; Vasoconstriction

2005
ADMA, endothelial progenitor cells, and cardiovascular risk.
    Circulation research, 2005, Oct-14, Volume: 97, Issue:8

    Topics: Arginine; Cardiovascular Diseases; Endothelial Cells; Humans; Risk Factors; Stem Cells

2005
Homocysteine-induced vascular dysregulation is mediated by the NMDA receptor.
    Vascular medicine (London, England), 2005, Volume: 10, Issue:3

    Topics: Animals; Aorta, Thoracic; Arginine; Cell Culture Techniques; Cell Movement; Cell Proliferation; Homocysteine; Interleukin-1; Matrix Metalloproteinase 9; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger

2005
L-NAME- and ADMA-induced sympathetic neural activation in conscious rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2006, Volume: 290, Issue:3

    Topics: Animals; Arginine; Baroreflex; Consciousness; Female; Kidney; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Sinoatrial Node; Sympathectomy; Sympathetic Nervous System

2006
Determination of asymmetric dimethylarginine: liquid chromatography-mass spectrometry or ELISA?
    Clinical chemistry, 2005, Volume: 51, Issue:11

    Topics: Arginine; Chromatography, Liquid; Enzyme-Linked Immunosorbent Assay; Humans; Hypercholesterolemia; Hypertriglyceridemia; Kidney Failure, Chronic; Mass Spectrometry

2005
Reduced nitric oxide concentration in the renal cortex of streptozotocin-induced diabetic rats: effects on renal oxygenation and microcirculation.
    Diabetes, 2005, Volume: 54, Issue:11

    Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Kidney Cortex; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Oxygen; Rats; Rats, Inbred WF; Renal Circulation

2005
Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine.
    Journal of the American College of Cardiology, 2005, Nov-01, Volume: 46, Issue:9

    Topics: Arginine; Cell Count; Cells, Cultured; Coronary Artery Disease; Endothelium, Vascular; Enzyme Inhibitors; Humans; Stem Cells

2005
ADMAring Endothelial Progenitor Cells Accident, Association, or Antecedent.
    Journal of the American College of Cardiology, 2005, Nov-01, Volume: 46, Issue:9

    Topics: Arginine; Cell Differentiation; Cell Movement; Endothelium, Vascular; Enzyme Inhibitors; Stem Cells

2005
In vitro and in vivo effects of probucol on hydrolysis of asymmetric dimethyl L-arginine and vasospasm in primates.
    Journal of neurosurgery, 2005, Volume: 103, Issue:4

    Topics: Animals; Antioxidants; Arginine; Bilirubin; Cell Culture Techniques; Double-Blind Method; Endothelial Cells; Enzyme Inhibitors; Hydrolysis; Lipid Peroxidation; Macaca fascicularis; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidation-Reduction; Placebos; Probucol; Random Allocation; Subarachnoid Hemorrhage; Time Factors; Umbilical Veins; Vasospasm, Intracranial

2005
Serum asymmetric dimethylarginine as a marker of coronary microcirculation in patients with non-insulin dependent diabetes mellitus: correlation with coronary flow reserve.
    Heart (British Cardiac Society), 2005, Volume: 91, Issue:12

    Topics: Aged; Arginine; Biomarkers; Blood Flow Velocity; Coronary Artery Disease; Coronary Circulation; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; Male; Microcirculation; Regression Analysis

2005
Lysophosphatidylcholine-induced elevation of asymmetric dimethylarginine level by the NADPH oxidase pathway in endothelial cells.
    Vascular pharmacology, 2006, Volume: 44, Issue:3

    Topics: Amidohydrolases; Arginine; Biphenyl Compounds; Cell Line; Cell Survival; Endothelial Cells; Enzyme Inhibitors; Humans; Lysophosphatidylcholines; NADPH Oxidases; Nitric Oxide; Onium Compounds; Protein-Arginine N-Methyltransferases; Reactive Oxygen Species; Repressor Proteins

2006
A role for asymmetric dimethylarginine in the pathophysiology of portal hypertension in rats with biliary cirrhosis.
    Hepatology (Baltimore, Md.), 2005, Volume: 42, Issue:6

    Topics: Acetylcholine; Animals; Arginine; Hypertension, Portal; Liver; Liver Cirrhosis, Biliary; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Thioacetamide; Vasodilation

2005
A gas, an amino acid, and an imposter: the story of nitric oxide, L-arginine, and ADMA in portal hypertension.
    Hepatology (Baltimore, Md.), 2005, Volume: 42, Issue:6

    Topics: Animals; Arginine; Hypertension, Portal; Nitric Oxide; Rats

2005
Comparison of HPLC method and commercial ELISA assay for asymmetric dimethylarginine (ADMA) determination in human serum.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006, Feb-02, Volume: 831, Issue:1-2

    Topics: Arginine; Calibration; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Humans

2006
Elevated serum interleukin-18 levels might reflect the high risk of hospitalization in patients on peritoneal dialysis.
    Nephrology (Carlton, Vic.), 2005, Volume: 10, Issue:6

    Topics: Aged; Arginine; Atherosclerosis; beta 2-Microglobulin; Biomarkers; Female; Hospitalization; Humans; Inflammation Mediators; Interleukin-18; Kidney Failure, Chronic; Male; Peritoneal Dialysis; Risk Factors

2005
Umbilical vein plasma concentrations of asymmetrical dimethylarginine are increased in male but not female neonates delivered preterm: a pilot study.
    Early human development, 2006, Volume: 82, Issue:7

    Topics: Arginine; Blood Circulation; Body Weight; Female; Fetal Blood; Humans; Infant, Newborn; Male; Nitric Oxide Synthase; Pilot Projects; Premature Birth; Sex Characteristics; Time Factors

2006
Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease.
    American journal of hypertension, 2005, Volume: 18, Issue:12 Pt 1

    Topics: Aged; Arginine; Atherosclerosis; Carotid Arteries; Carotid Artery Diseases; Female; Gene Frequency; Genotype; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase Type III; Polymorphism, Genetic; Regression Analysis; Tunica Intima; Tunica Media; White People

2005
Elevations of plasma methylarginines in obesity and ageing are related to insulin sensitivity and rates of protein turnover.
    Diabetologia, 2006, Volume: 49, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Arginine; Blood Glucose; Body Composition; Female; Glucose; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Lipids; Male; Metabolic Syndrome; Middle Aged; Obesity; omega-N-Methylarginine; Proteins; Regression Analysis; Sex Characteristics

2006
Treatment with niacin lowers ADMA.
    Atherosclerosis, 2006, Volume: 184, Issue:2

    Topics: Adult; Aged; Arginine; Atherosclerosis; Biomarkers; Female; Humans; Hypolipidemic Agents; Male; Middle Aged; Niacin; Nitric Oxide Synthase; Risk Factors; Treatment Outcome

2006
The determinants of endothelial dysfunction in CKD: oxidative stress and asymmetric dimethylarginine.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2006, Volume: 47, Issue:1

    Topics: Adult; Arginine; Brachial Artery; Cardiovascular Diseases; Chronic Disease; Copper; Endothelium, Vascular; Erythrocytes; Female; Glomerular Filtration Rate; Glutathione Peroxidase; Humans; Kidney Diseases; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Selenium; Severity of Illness Index; Superoxide Dismutase; Vasodilation; Zinc

2006
Accumulation of symmetric dimethylarginine in hepatorenal syndrome.
    Experimental biology and medicine (Maywood, N.J.), 2006, Volume: 231, Issue:1

    Topics: Arginine; Case-Control Studies; Creatinine; Fibrosis; Hepatorenal Syndrome; Humans; Kidney; Liver; Male; Middle Aged; Nitric Oxide; Renal Insufficiency

2006
Fast and efficient determination of arginine, symmetric dimethylarginine, and asymmetric dimethylarginine in biological fluids by hydrophilic-interaction liquid chromatography-electrospray tandem mass spectrometry.
    Clinical chemistry, 2006, Volume: 52, Issue:3

    Topics: Adult; Arginine; Body Fluids; Cells, Cultured; Chromatography, Liquid; Female; Humans; Male; Middle Aged; Spectrometry, Mass, Electrospray Ionization

2006
Abnormal nitric oxide metabolism in systemic sclerosis: increased levels of nitrated proteins and asymmetric dimethylarginine.
    Rheumatology (Oxford, England), 2006, Volume: 45, Issue:6

    Topics: Adult; Arginine; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Raynaud Disease; Scleroderma, Diffuse; Scleroderma, Limited; Scleroderma, Systemic; Severity of Illness Index

2006
Detection of dimethylarginines in protein hydrolysates by matrix-assisted laser desorption/ionization mass spectrometry.
    Analytical biochemistry, 2006, Mar-01, Volume: 350, Issue:1

    Topics: Animals; Arginine; Blood Proteins; Collodion; Coumaric Acids; Fish Proteins; Protein Hydrolysates; Protein-Arginine N-Methyltransferases; Repressor Proteins; Saccharomyces cerevisiae Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2006
Endurance training reduces circulating asymmetric dimethylarginine and myeloperoxidase levels in persons at risk of coronary events.
    Thrombosis and haemostasis, 2005, Volume: 94, Issue:6

    Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Cyclic GMP; Exercise; Female; Humans; Male; Middle Aged; Peroxidase; Risk Factors

2005
Asymmetric dimethylarginine is associated with macrovascular disease and total homocysteine in patients with type 2 diabetes.
    Atherosclerosis, 2006, Volume: 189, Issue:1

    Topics: Aged; Arginine; Arterial Occlusive Diseases; Biomarkers; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Homocysteine; Humans; Hypoglycemic Agents; Incidence; Male; Middle Aged; Nitric Oxide Synthase; Prognosis; Risk Factors; Severity of Illness Index

2006
Estrogen replacement effectively improves the accelerated intimal hyperplasia following balloon injury of carotid artery in the ovariectomized rats.
    Journal of cardiovascular pharmacology, 2006, Volume: 47, Issue:1

    Topics: Animals; Arginine; Carotid Arteries; Catheterization; Cyclic GMP; Estradiol; Estrogen Replacement Therapy; Female; Follicle Stimulating Hormone; Hyperplasia; Immunohistochemistry; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Ovariectomy; Rats; Rats, Sprague-Dawley; Tunica Intima; Vasodilation

2006
Coronary endothelial dysfunction is associated with erectile dysfunction and elevated asymmetric dimethylarginine in patients with early atherosclerosis.
    European heart journal, 2006, Volume: 27, Issue:7

    Topics: Arginine; C-Reactive Protein; Coronary Artery Disease; Endothelium, Vascular; Erectile Dysfunction; Humans; Male; Middle Aged; Risk Factors

2006
ADMA: an emerging cardiovascular risk factor.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Animals; Arginine; Cardiovascular Physiological Phenomena; Humans; Nitric Oxide Synthase

2005
Asymmetric dimethylarginine (ADMA) accelerates cell senescence.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Amidohydrolases; Arginine; Cells, Cultured; Cellular Senescence; Chemokine CCL2; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Humans; Interleukin-8; Nitric Oxide Synthase; Oxidative Stress; Reactive Oxygen Species; S-Adenosylhomocysteine; Telomerase

2005
ADMA and oxidative stress may relate to the progression of renal disease: rationale and design of the VIVALDI study.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Arginine; Benzimidazoles; Benzoates; Clinical Protocols; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dinoprost; Endothelium, Vascular; Humans; Hypertension; Middle Aged; Multicenter Studies as Topic; Oxidative Stress; Randomized Controlled Trials as Topic; Renal Insufficiency; Telmisartan; Tetrazoles; Valine; Valsartan

2005
Effect of vasoconstrictor coupling factor 6 on gene expression profile in human vascular endothelial cells: enhanced release of asymmetric dimethylarginine.
    Journal of hypertension, 2006, Volume: 24, Issue:3

    Topics: Amidohydrolases; Arginine; Blotting, Western; Cells, Cultured; Endothelial Cells; Gene Expression Profiling; Humans; Mitochondrial Proton-Translocating ATPases; Nitric Oxide Synthase; Oligonucleotide Array Sequence Analysis; Oxidative Phosphorylation Coupling Factors; Protein-Arginine N-Methyltransferases; Umbilical Veins

2006
Asymmetric arginine dimethylation of heterogeneous nuclear ribonucleoprotein K by protein-arginine methyltransferase 1 inhibits its interaction with c-Src.
    The Journal of biological chemistry, 2006, Apr-21, Volume: 281, Issue:16

    Topics: Amino Acid Sequence; Arginine; CSK Tyrosine-Protein Kinase; DNA Methylation; Dose-Response Relationship, Drug; Embryo, Mammalian; Ethanolamines; HeLa Cells; Heterogeneous-Nuclear Ribonucleoprotein K; Humans; Mass Spectrometry; Methylation; Microscopy, Fluorescence; Molecular Sequence Data; Phosphorylation; Plasmids; Protein Binding; Protein Biosynthesis; Protein Interaction Mapping; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein-Arginine N-Methyltransferases; Protein-Tyrosine Kinases; Recombinant Proteins; Repressor Proteins; RNA; Sepharose; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; src-Family Kinases; Stem Cells; Transcription, Genetic; Transfection

2006
Asymmetric dimethylarginine induces apoptosis via p38 MAPK/caspase-3-dependent signaling pathway in endothelial cells.
    Journal of molecular and cellular cardiology, 2006, Volume: 40, Issue:4

    Topics: Apoptosis; Arginine; Caspase 3; Caspases; Cells, Cultured; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; MAP Kinase Signaling System; Nitric Oxide Synthase Type III; p38 Mitogen-Activated Protein Kinases; Pyridines; Umbilical Veins

2006
Dimethylarginine dimethylaminohydrolase inhibition and asymmetric dimethylarginine accumulation contribute to endothelial dysfunction in rats exposed to glycosylated protein: effects of aminoguanidine.
    Atherosclerosis, 2007, Volume: 190, Issue:1

    Topics: Amidohydrolases; Animals; Antioxidants; Aorta; Arginine; Blood Proteins; Endothelium, Vascular; Enzyme Inhibitors; Glycosylation; Guanidines; Lipid Peroxidation; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Vasodilation

2007
[Protective effect of losartan on injury induced by ox-LDL in endothelial cells and the relationship with asymmetric dimethylarginine].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2006, Volume: 31, Issue:1

    Topics: Amidohydrolases; Arginine; Cells, Cultured; Endothelium, Vascular; Humans; L-Lactate Dehydrogenase; Lipoproteins, LDL; Losartan; Nitric Oxide; Protective Agents; Umbilical Veins

2006
Asymmetric dimethylarginine in homocystinuria due to cystathionine beta-synthase deficiency: relevance of renal function.
    Journal of inherited metabolic disease, 2006, Volume: 29, Issue:1

    Topics: Adult; Arginine; Creatinine; Cystathionine beta-Synthase; Cystatin C; Cystatins; Female; Homocysteine; Homocystinuria; Humans; Kidney; Male; Middle Aged; Nitrates; Nitrites; Pyridoxine; Renal Insufficiency

2006
Analysis of asymmetric dimethylarginine in plasma by HPLC using a monolithic column.
    Analytical biochemistry, 2006, Jun-15, Volume: 353, Issue:2

    Topics: Arginine; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results

2006
Plasma asymmetric dimethylarginine (ADMA), nitrate and the indices of low-density lipoprotein oxidation.
    Clinica chimica acta; international journal of clinical chemistry, 2006, Volume: 371, Issue:1-2

    Topics: Adult; Aged; Arginine; Atherosclerosis; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lipid Metabolism; Lipid Peroxidation; Lipoproteins, LDL; Male; Mass Spectrometry; Middle Aged; Nitrates; Nitric Oxide; Risk Factors

2006
Intensive treatment of risk factors in patients with type-2 diabetes mellitus is associated with improvement of endothelial function coupled with a reduction in the levels of plasma asymmetric dimethylarginine and endogenous inhibitor of nitric oxide synt
    European heart journal, 2006, Volume: 27, Issue:10

    Topics: Arginine; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Female; Humans; Hyperglycemia; Male; Middle Aged; Nitric Oxide Synthase; Risk Factors; Tumor Necrosis Factor-alpha

2006
Urotensin II and biomarkers of endothelial activation and atherosclerosis in end-stage renal disease.
    American journal of hypertension, 2006, Volume: 19, Issue:5

    Topics: Arginine; Atherosclerosis; Biomarkers; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Immunoenzyme Techniques; Intercellular Adhesion Molecule-1; Kidney Failure, Chronic; Male; Middle Aged; Regression Analysis; Risk Factors; Urotensins

2006
Plasma levels of asymmetric dimethylarginine (ADMA) are related to intima-media thickness of the carotid artery: an epidemiological study.
    Atherosclerosis, 2007, Volume: 191, Issue:1

    Topics: Aged; Arginine; Blood Pressure; Carotid Arteries; Female; Humans; Japan; Male; Middle Aged; Multivariate Analysis; Tunica Intima; Ultrasonography

2007
Effect of L-arginine on asymmetric dimethylarginine (ADMA) or homocysteine-accelerated endothelial cell aging.
    Biochemical and biophysical research communications, 2006, Jul-07, Volume: 345, Issue:3

    Topics: Aging; Arginine; Cells, Cultured; Cellular Senescence; Endothelial Cells; Endothelium, Vascular; Homocysteine; Humans; NG-Nitroarginine Methyl Ester; Oxidative Stress; Telomerase; Time Factors

2006
L-arginine chlorination results in the formation of a nonselective nitric-oxide synthase inhibitor.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 318, Issue:3

    Topics: Animals; Arginine; Cyclic GMP; Enzyme Inhibitors; Hypochlorous Acid; Male; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilation

2006
Evidence for associations between common polymorphisms of estrogen receptor beta gene with homocysteine and nitric oxide.
    Climacteric : the journal of the International Menopause Society, 2006, Volume: 9, Issue:3

    Topics: Aged; Arginine; Body Mass Index; Cardiovascular Diseases; Cross-Sectional Studies; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Folic Acid; Genetic Variation; Genotype; Homocysteine; Humans; Linkage Disequilibrium; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Polymorphism, Single Nucleotide; Postmenopause; Risk Factors; Vitamin B 12

2006
Determination of NG,NG-dimethyl-L-arginine in rat plasma and dimethylarginine dimethylaminohydrolase activity in rat kidney using a monolithic silica column.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006, Nov-07, Volume: 843, Issue:2

    Topics: Amidohydrolases; Animals; Arginine; Chromatography, High Pressure Liquid; Kidney; Male; Rats; Rats, Sprague-Dawley; Silicon Dioxide

2006
Adverse effects of cigarette smoke on NO bioavailability: role of arginine metabolism and oxidative stress.
    Hypertension (Dallas, Tex. : 1979), 2006, Volume: 48, Issue:2

    Topics: Adult; Animals; Antioxidants; Arginine; Biological Availability; Biological Transport; Cationic Amino Acid Transporter 1; Cattle; Cells, Cultured; Citrulline; Cotinine; Culture Media; Endothelial Cells; Enzyme Activation; Humans; Male; Nicotiana; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Oxidative Stress; Reactive Oxygen Species; Smoke; Smoking

2006
Molecular mechanism for elevation of asymmetric dimethylarginine and its role for hypertension in chronic kidney disease.
    Journal of the American Society of Nephrology : JASN, 2006, Volume: 17, Issue:8

    Topics: Adenoviridae; Amidohydrolases; Animals; Arginine; Cholesterol; Hypertension; Kidney; Kidney Failure, Chronic; Kinetics; Liver; Male; Nephrectomy; Protein-Arginine N-Methyltransferases; Rats; Rats, Sprague-Dawley; Time Factors

2006
ADMA, proteinuria, and insulin resistance in non-diabetic stage I chronic kidney disease.
    Kidney international, 2006, Volume: 70, Issue:4

    Topics: Adult; Arginine; Biomarkers; C-Reactive Protein; Case-Control Studies; Chronic Disease; Disease Progression; Female; Homeostasis; Humans; Insulin; Insulin Resistance; Kidney Diseases; Male; Proteinuria; Regression Analysis

2006
Asymmetrical dimethylarginine (ADMA) and coronary endothelial function in patients with coronary artery disease and mild hypercholesterolemia.
    Atherosclerosis, 2007, Volume: 191, Issue:1

    Topics: Acetylcholine; Adenosine; Aged; Arginine; Coronary Artery Disease; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Nitroglycerin; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

2007
Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of ADMA.
    American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 292, Issue:1

    Topics: Adult; Amidohydrolases; Animals; Arginine; Bronchoalveolar Lavage Fluid; Cardiovascular System; Female; Humans; In Vitro Techniques; Kidney; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Myocardium; Nitric Oxide; Protein-Arginine N-Methyltransferases

2007
Letter by Kielstein et al regarding article, "Renal function as a predictor of outcome in a broad spectrum of patients with heart failure".
    Circulation, 2006, Aug-08, Volume: 114, Issue:6

    Topics: Angiotensin-Converting Enzyme Inhibitors; Arginine; Cardiac Output, Low; Creatinine; Disease Progression; Glomerular Filtration Rate; Humans; Kidney; Kidney Failure, Chronic; Predictive Value of Tests; Risk Factors

2006
Probucol decreases asymmetrical dimethylarginine level by alternation of protein arginine methyltransferase I and dimethylarginine dimethylaminohydrolase activity.
    Cardiovascular drugs and therapy, 2006, Volume: 20, Issue:4

    Topics: Amidohydrolases; Antioxidants; Arginine; Cell Line; Endothelial Cells; Humans; L-Lactate Dehydrogenase; Lipoproteins, LDL; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type III; Probucol; Protein-Arginine N-Methyltransferases

2006
Epigallocatechin gallate preserves endothelial function by reducing the endogenous nitric oxide synthase inhibitor level.
    Canadian journal of physiology and pharmacology, 2006, Volume: 84, Issue:2

    Topics: Animals; Arginine; Catechin; Cells, Cultured; Cholesterol, LDL; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Male; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Vasodilation

2006
Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study.
    American heart journal, 2006, Volume: 152, Issue:3

    Topics: Aged; Arginine; Case-Control Studies; Coronary Disease; Female; Humans; Male; Middle Aged; Risk Factors

2006
Cigarettes and ADMA: the smoke hasn't cleared yet.
    Hypertension (Dallas, Tex. : 1979), 2006, Volume: 48, Issue:4

    Topics: Arginine; Endothelial Cells; Humans; Nicotiana; Nitric Oxide Synthase; Osmolar Concentration; Smoke

2006
Proceedings of the 2nd International Symposium on ADMA -- An Emerging Cardiovascular Risk Factor, November 6, 2004, New Orleans, Louisiana, USA.
    Vascular medicine (London, England), 2005, Volume: 10 Suppl 1

    Topics: Animals; Arginine; Cardiovascular Physiological Phenomena; Humans; Nitric Oxide Synthase

2005
Gene polymorphism and requirement for vasopressor infusion after cardiac surgery.
    The Annals of thoracic surgery, 2006, Volume: 82, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Aged; Alleles; Amidohydrolases; Arginine; Cardiac Surgical Procedures; Casein Kinase II; Cohort Studies; Comorbidity; Elective Surgical Procedures; Epinephrine; Female; Genetic Predisposition to Disease; Genotype; Histocompatibility Antigens Class II; Humans; Inflammation; Lymphotoxin-alpha; Major Histocompatibility Complex; Male; Middle Aged; Norepinephrine; Polymorphism, Single Nucleotide; Postoperative Complications; Tumor Necrosis Factor-alpha; Vascular Resistance; Vasoconstrictor Agents; Vasodilation

2006
Asymmetric dimethylarginine predicts major adverse cardiovascular events in patients with advanced peripheral artery disease.
    Arteriosclerosis, thrombosis, and vascular biology, 2006, Volume: 26, Issue:11

    Topics: Aged; Arginine; Arteries; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Cohort Studies; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Osmolar Concentration; Peripheral Vascular Diseases; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Severity of Illness Index

2006
Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression.
    Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 102, Issue:1

    Topics: Adolescent; Adult; Aged; Aging; Amidohydrolases; Arginine; Biological Availability; Brachial Artery; Carotid Arteries; Endothelium, Vascular; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Regional Blood Flow; Vasodilation

2007
Involvement of DDAH/ADMA/NOS pathway in nicotine-induced endothelial dysfunction.
    Biochemical and biophysical research communications, 2006, Oct-20, Volume: 349, Issue:2

    Topics: Amidohydrolases; Animals; Arginine; Calcium; Endothelium, Vascular; Humans; Male; Nicotine; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; RNA, Messenger; Vascular Diseases

2006
Salt loading on plasma asymmetrical dimethylarginine and the protective role of potassium supplement in normotensive salt-sensitive asians.
    Hypertension (Dallas, Tex. : 1979), 2006, Volume: 48, Issue:4

    Topics: Adult; Arginine; Asian People; Blood Pressure; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Osmolar Concentration; Potassium, Dietary; Reference Values; Sodium Chloride, Dietary

2006
Elevated plasma asymmetric dimethyl-L-arginine in a patient with Gordon syndrome.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2007, Volume: 22, Issue:1

    Topics: Arginine; Diagnosis, Differential; Electrolytes; Female; Humans; Hyperkalemia; Hypertension; Middle Aged; Nitric Oxide; Pseudohypoaldosteronism; Syndrome

2007
Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study.
    Critical care (London, England), 2006, Volume: 10, Issue:5

    Topics: Alleles; Amidohydrolases; Arginine; Female; Genetic Variation; Humans; Male; Polymorphism, Genetic; Prospective Studies; Shock, Septic

2006
Accurate quantification of dimethylamine (DMA) in human urine by gas chromatography-mass spectrometry as pentafluorobenzamide derivative: evaluation of the relationship between DMA and its precursor asymmetric dimethylarginine (ADMA) in health and disease
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, May-15, Volume: 851, Issue:1-2

    Topics: Acetazolamide; Adult; Arginine; Benzamides; Circadian Rhythm; Coronary Artery Disease; Dimethylamines; Diuretics; Female; Gas Chromatography-Mass Spectrometry; Health; Humans; Liver Diseases; Male; Middle Aged; Quality Control; Time Factors; Urinalysis

2007
Asymmetric dimethylarginine (ADMA) and hyperhomocysteinemia in patients with acute myocardial infarction.
    Clinical biochemistry, 2007, Volume: 40, Issue:1-2

    Topics: Aged; Arginine; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Middle Aged; Myocardial Infarction; Regression Analysis; Risk Factors; Statistics, Nonparametric; Stereoisomerism

2007
Asymmetric dimethylarginine is not elevated in exfoliation syndrome but symmetric dimethylarginine is related to exfoliative glaucoma.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2007, Volume: 245, Issue:2

    Topics: Aged; Arginine; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Exfoliation Syndrome; Female; Glaucoma; Homocysteine; Humans; Male; Oxidative Stress; Prospective Studies

2007
Asymmetric dimethylarginine and cerebrovascular disorders in humans.
    Stroke, 2006, Volume: 37, Issue:12

    Topics: Arginine; Cerebrovascular Disorders; Humans; Nitric Oxide Synthase

2006
Plasma asymmetric dimethylarginine level and extent of lesion at coronary angiography.
    Coronary artery disease, 2006, Volume: 17, Issue:7

    Topics: Adolescent; Adult; Aged; Angina Pectoris; Arginine; Coronary Angiography; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Risk; Severity of Illness Index

2006
Association of homocysteine and asymmetric dimethylarginine with atherosclerosis and cardiovascular events in maintenance hemodialysis patients.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2006, Volume: 48, Issue:5

    Topics: Arginine; Atherosclerosis; Cardiovascular Diseases; Comorbidity; Female; Homocysteine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase; Proportional Hazards Models; Regression Analysis; Renal Dialysis; Risk Factors

2006
Medium-term methionine supplementation increases plasma homocysteine but not ADMA and improves blood pressure control in rats fed a diet rich in protein and adequate in folate and choline.
    European journal of nutrition, 2006, Volume: 45, Issue:7

    Topics: Adaptation, Physiological; Animals; Area Under Curve; Arginine; Blood Pressure; Choline; Dietary Proteins; Dietary Supplements; Folic Acid; Homocysteine; Male; Methionine; Methylation; Nitric Oxide; Random Allocation; Rats; Rats, Wistar; Time Factors

2006
Level of asymmetric dimethylarginine and carotid atherosclerosis in patients with chronic kidney disease.
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2006, Volume: 31, Issue:5

    Topics: Adult; Arginine; Carotid Artery Diseases; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase; Renal Dialysis

2006
[Effect of asymmetric dimethylarginine on platelet-aggregation and losartan intervention in spontaneous hypertensive rat models].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2006, Volume: 31, Issue:5

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Arginine; Hypertension; Losartan; Male; Platelet Aggregation; Rats; Rats, Inbred SHR; Rats, Inbred WKY

2006
Farnesoid X receptor agonist reduces serum asymmetric dimethylarginine levels through hepatic dimethylarginine dimethylaminohydrolase-1 gene regulation.
    The Journal of biological chemistry, 2006, Dec-29, Volume: 281, Issue:52

    Topics: Amidohydrolases; Animals; Arginine; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Humans; Isoxazoles; Liver; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Transcription Factors

2006
Vaso-occlusion in Schimke-immuno-osseous dysplasia: is the NO pathway involved?
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2006, Volume: 38, Issue:10

    Topics: Adolescent; Adult; Arginine; Arterial Occlusive Diseases; Atherosclerosis; Child; Child, Preschool; Female; Glomerulosclerosis, Focal Segmental; Humans; Male; Nephrotic Syndrome; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Osteochondrodysplasias

2006
Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function.
    The Journal of biological chemistry, 2007, Jan-12, Volume: 282, Issue:2

    Topics: Animals; Aorta; Arginine; Carotid Artery Injuries; Catheterization; Cattle; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Kinetics; Male; Methylation; Nitric Oxide; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Rats; Rats, Wistar; Vasodilation

2007
Effects of breed, gender, exercise and white-coat effect on markers of endothelial function in dogs.
    Research in veterinary science, 2007, Volume: 82, Issue:3

    Topics: Alaska; Animals; Arginine; Biomarkers; Color; Dogs; Endothelium; Enzyme Inhibitors; Female; Gene Expression Regulation; Hair; Male; Nitric Oxide; Physical Conditioning, Animal; Sex Characteristics; von Willebrand Factor

2007
Live and let die: asymmetric dimethylarginine and septic shock.
    Critical care (London, England), 2006, Volume: 10, Issue:6

    Topics: Arginine; Critical Illness; Humans; Nitric Oxide; Nitric Oxide Synthase; Shock, Septic

2006
Asymmetric dimethylarginine reduced erythrocyte deformability in streptozotocin-induced diabetic rats.
    Microvascular research, 2007, Volume: 73, Issue:2

    Topics: Animals; Aorta, Thoracic; Arginine; Diabetes Mellitus, Experimental; Endothelium, Vascular; Erythrocyte Deformability; In Vitro Techniques; Male; Malondialdehyde; Nitric Oxide; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Vitamin E

2007
Asymmetric dimethylarginine and nitric oxide levels as signs of endothelial dysfunction in Behcet's disease.
    Annals of clinical and laboratory science, 2006,Autumn, Volume: 36, Issue:4

    Topics: Adult; Arginine; Behcet Syndrome; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Vasculitis

2006
Insulin and adiponectin inhibit the TNFalpha-induced ADMA accumulation in human endothelial cells: the role of DDAH.
    Atherosclerosis, 2007, Volume: 194, Issue:2

    Topics: Adiponectin; Amidohydrolases; Arginine; Cells, Cultured; Coronary Vessels; Endothelial Cells; Humans; Insulin; Tumor Necrosis Factor-alpha; Umbilical Veins

2007
Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine in citrullinemia.
    Metabolism: clinical and experimental, 2006, Volume: 55, Issue:12

    Topics: Arginine; Citrullinemia; Enzyme Inhibitors; Humans; Nitric Oxide; Nitric Oxide Synthase

2006
Asymmetric dimethylarginine induces oxidative and nitrosative stress in murine lung epithelial cells.
    American journal of respiratory cell and molecular biology, 2007, Volume: 36, Issue:5

    Topics: Animals; Arginine; Cell Line; Epithelial Cells; Ethidium; Fluorescence; Interferon-gamma; Lipopolysaccharides; Lung; Mice; Models, Biological; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Nitrosation; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Rhodamines; Superoxides; Tumor Necrosis Factor-alpha

2007
Nontraditional atherosclerotic risk factors and extent of coronary atherosclerosis in patients with combined impaired fasting glucose and impaired glucose tolerance.
    Metabolism: clinical and experimental, 2007, Volume: 56, Issue:1

    Topics: Adult; Aged; Arginine; Blood Glucose; C-Reactive Protein; Cholesterol; Coronary Artery Disease; Discriminant Analysis; Female; Glucose Clamp Technique; Homocysteine; Humans; Insulin Resistance; Male; Middle Aged; Risk Factors; Triglycerides

2007
Asymmetric dimethyl-arginine (ADMA) response to inflammation in acute infections.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2007, Volume: 22, Issue:3

    Topics: Acute Disease; Arginine; Bacterial Infections; Biomarkers; Blood Pressure; C-Reactive Protein; Calcitonin; Calcitonin Gene-Related Peptide; Chromatography, High Pressure Liquid; Creatinine; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Glycoproteins; Humans; Inflammation; Interleukin-6; Male; Middle Aged; Nitric Oxide Synthase; Protein Precursors; Severity of Illness Index; Tyrosine

2007
Asymmetric dimethylarginine, cortisol/cortisone ratio, and C-peptide: markers for diabetes and cardiovascular risk?
    American heart journal, 2007, Volume: 153, Issue:1

    Topics: Arginine; Biomarkers; Blood Glucose; C-Peptide; Case-Control Studies; Coronary Disease; Cortisone; Diabetes Mellitus; Female; Humans; Hydrocortisone; Hyperinsulinism; Logistic Models; Male; Middle Aged; Myocardial Infarction; Nitric Oxide Synthase; Predictive Value of Tests; Risk Assessment

2007
Asymmetrical dimethylarginine independently predicts total and cardiovascular mortality in individuals with angiographic coronary artery disease (the Ludwigshafen Risk and Cardiovascular Health study).
    Clinical chemistry, 2007, Volume: 53, Issue:2

    Topics: Analysis of Variance; Arginine; Biomarkers; Cardiovascular Diseases; Coronary Angiography; Coronary Disease; Female; Humans; Male; Middle Aged; Mortality; Predictive Value of Tests; Regression Analysis; Risk Factors

2007
Increasing dimethylarginine levels are associated with adverse clinical outcome in severe alcoholic hepatitis.
    Hepatology (Baltimore, Md.), 2007, Volume: 45, Issue:1

    Topics: Adult; Aged; Amidohydrolases; Arginine; Biomarkers; Case-Control Studies; Female; Gene Expression Regulation; Hepatitis, Alcoholic; Humans; Hypertension, Portal; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Predictive Value of Tests; Prognosis; Protein-Arginine N-Methyltransferases; Repressor Proteins; Sensitivity and Specificity; Survival Rate

2007
High-throughput liquid chromatographic-tandem mass spectrometric determination of arginine and dimethylated arginine derivatives in human and mouse plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, May-15, Volume: 851, Issue:1-2

    Topics: Analytic Sample Preparation Methods; Animals; Arginine; Chromatography, Liquid; Humans; Mice; Mice, Inbred C57BL; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2007
Asymmetric dimethylarginine in cerebral small vessel disease.
    Stroke, 2007, Volume: 38, Issue:2

    Topics: Aged; Arginine; Cerebrovascular Circulation; Cerebrovascular Disorders; Female; Humans; Leukoaraiosis; Male; Microcirculation; Middle Aged

2007
[Effect of puerarin on ADMA-DDAH system in human umbilical vein endothelial cells cultured with oxidized free radical].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2006, Volume: 26, Issue:12

    Topics: Amidohydrolases; Arginine; Blotting, Western; Cells, Cultured; Culture Media; Endothelial Cells; Endothelins; Free Radicals; Humans; Isoflavones; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidation-Reduction; Umbilical Veins

2006
Increased plasma levels of asymmetric dimethylarginine in patients with carotid stenosis: no evidence for the role of the common FABP2 A54T gene polymorphism.
    Acta neurologica Scandinavica, 2007, Volume: 115, Issue:2

    Topics: Aged; Arginine; Carotid Artery, Internal; Carotid Stenosis; Case-Control Studies; Fatty Acid-Binding Proteins; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Ultrasonography

2007
Plasma concentrations of asymmetric dimethylarginine (ADMA) in metabolic syndrome.
    International journal of cardiology, 2007, Nov-15, Volume: 122, Issue:2

    Topics: Adolescent; Adult; Arginine; C-Reactive Protein; Colombia; Humans; Insulin Resistance; Male; Metabolic Syndrome; White People

2007
Asymmetrical dimethylarginine inhibits shear stress-induced nitric oxide release and dilation and elicits superoxide-mediated increase in arteriolar tone.
    Hypertension (Dallas, Tex. : 1979), 2007, Volume: 49, Issue:3

    Topics: Animals; Arginine; Arterioles; Enzyme Inhibitors; Male; Models, Animal; Muscle, Skeletal; Nitric Oxide; Rats; Rats, Wistar; Shear Strength; Stress, Mechanical; Superoxides; Vascular Resistance; Vasoconstriction; Vasodilation

2007
Asymmetric dimethylarginine (ADMA) induces vascular endothelium impairment and aggravates post-ischemic ventricular dysfunction in rats.
    European journal of pharmacology, 2007, Feb-28, Volume: 557, Issue:2-3

    Topics: Acetylcholine; Angiotensin II; Animals; Aorta; Arginine; Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Heart Rate; Male; Myocardial Reperfusion Injury; Nitrates; Nitrites; Perfusion; Rats; Rats, Wistar; RNA, Messenger; Vasoconstrictor Agents; Vasodilator Agents; Ventricular Dysfunction

2007
Should we measure asymmetric dimethylarginine in patients with coronary artery disease?
    Clinical chemistry, 2007, Volume: 53, Issue:2

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Coronary Artery Disease; Humans; Mortality; Predictive Value of Tests; Risk Factors

2007
Asymmetric dimethylarginine and reduced nitric oxide bioavailability in young Black African men.
    Hypertension (Dallas, Tex. : 1979), 2007, Volume: 49, Issue:4

    Topics: Adult; Arginine; Biological Availability; Black People; Brachial Artery; Endothelium, Vascular; Enzyme Inhibitors; Humans; Male; Nitric Oxide; Regional Blood Flow; Regression Analysis; Single-Blind Method; Ultrasonography; Vasodilation; White People

2007
[Dimethylarginine dimethylaminohydrolase and endothelium dysfunction].
    Sheng li ke xue jin zhan [Progress in physiology], 2006, Volume: 37, Issue:4

    Topics: Amidohydrolases; Animals; Arginine; Endothelium, Vascular; Humans; Vascular Diseases

2006
[The influence of tobacco smoke on plasma atherogenic compounds levels in active smokers (preliminary report)].
    Przeglad lekarski, 2006, Volume: 63, Issue:10

    Topics: Adult; Arginine; Chromatography, High Pressure Liquid; Cotinine; Homocystine; Humans; Male; Middle Aged; Smoking

2006
Dimethylarginines at the crossroad of insulin resistance and atherosclerosis.
    Metabolism: clinical and experimental, 2007, Volume: 56, Issue:3

    Topics: Adult; Arginine; Atherosclerosis; Female; Humans; Insulin Resistance; Male; Middle Aged

2007
Taurine protects against low-density lipoprotein-induced endothelial dysfunction by the DDAH/ADMA pathway.
    Vascular pharmacology, 2007, Volume: 46, Issue:5

    Topics: Acetylcholine; Amidohydrolases; Animals; Arginine; Cardiovascular Agents; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Humans; Lipoproteins, LDL; Male; Malondialdehyde; Nitric Oxide; Rats; Rats, Sprague-Dawley; Taurine; Time Factors; Tumor Necrosis Factor-alpha; Vasodilation; Vasodilator Agents; Vitamin E

2007
A stable-isotope based technique for the determination of dimethylarginine dimethylaminohydrolase (DDAH) activity in mouse tissue.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, May-15, Volume: 851, Issue:1-2

    Topics: Amidohydrolases; Animals; Arginine; Chromatography, High Pressure Liquid; Isotope Labeling; Kidney; Liver; Mice; Mice, Inbred C57BL; Reproducibility of Results; Tandem Mass Spectrometry

2007
Asymmetric dimethylarginine, smoking, and risk of coronary heart disease in apparently healthy men: prospective analysis from the population-based Monitoring of Trends and Determinants in Cardiovascular Disease/Kooperative Gesundheitsforschung in der Regi
    Clinical chemistry, 2007, Volume: 53, Issue:4

    Topics: Adult; Aged; Arginine; Case-Control Studies; Cell Line; Coronary Disease; Endothelium, Vascular; Female; Humans; Male; Mass Screening; Middle Aged; Nitric Oxide Synthase; Plasma; Prospective Studies; Risk; Smoking

2007
Arterial wave reflections and determinants of endothelial function a hypothesis based on peripheral mode of action.
    American journal of hypertension, 2007, Volume: 20, Issue:3

    Topics: Age Factors; Aged; Aorta; Arginine; Blood Flow Velocity; Blood Pressure; Coronary Artery Disease; Cross-Sectional Studies; Elasticity; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Humans; Linear Models; Male; Manometry; Middle Aged; Predictive Value of Tests; Prospective Studies; Pulsatile Flow; Radial Artery

2007
The ADMA/DDAH pathway is a critical regulator of endothelial cell motility.
    Journal of cell science, 2007, Mar-15, Volume: 120, Issue:Pt 6

    Topics: Actin Cytoskeleton; Amidohydrolases; Animals; Arginine; cdc42 GTP-Binding Protein; Cell Movement; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytoskeleton; Endothelial Cells; Enzyme Activation; Focal Adhesions; Lung; Mice; Mice, Knockout; Neovascularization, Physiologic; rac1 GTP-Binding Protein; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; Signal Transduction; Stress Fibers; Swine

2007
Elevated plasma asymmetric dimethyl-L-arginine levels are linked to endothelial progenitor cell depletion and carotid atherosclerosis in rheumatoid arthritis.
    Arthritis and rheumatism, 2007, Volume: 56, Issue:3

    Topics: Adult; Arginine; Arthritis, Rheumatoid; Carotid Arteries; Carotid Artery Diseases; Case-Control Studies; Cell Count; Endothelial Cells; Female; Humans; Male; Mesenchymal Stem Cells; Middle Aged; Nitric Oxide; Ultrasonography

2007
Dimethylarginine dimethylaminohydrolase promotes endothelial repair after vascular injury.
    Journal of the American College of Cardiology, 2007, Mar-13, Volume: 49, Issue:10

    Topics: Amidohydrolases; Animals; Arginine; Cell Proliferation; Disease Models, Animal; Endothelium, Vascular; Enzyme Induction; Femoral Artery; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neovascularization, Physiologic; Nitric Oxide; Probability; Random Allocation; Sensitivity and Specificity; Species Specificity; Vascular Diseases

2007
ADMA is independently related to flow-mediated vasodilation in subjects at low cardiovascular risk.
    European journal of clinical investigation, 2007, Volume: 37, Issue:4

    Topics: Adult; Aged; Analysis of Variance; Arginine; Cardiovascular Diseases; Endothelium, Vascular; Female; Humans; Insulin; Male; Middle Aged; Risk Factors; Vasodilation

2007
Asymmetric dimethylarginine (ADMA) in the aqueous humor of diabetic patients.
    Endocrine journal, 2007, Volume: 54, Issue:2

    Topics: Aged; Aqueous Humor; Arginine; Cataract; Cataract Extraction; Diabetes Complications; Diabetes Mellitus; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Nitrates; Nitrites

2007
Serum asymmetric dimethylarginine negatively correlates with intima-media thickness in early-onset atherosclerosis.
    Cerebrovascular diseases (Basel, Switzerland), 2007, Volume: 23, Issue:5-6

    Topics: Age of Onset; Arginine; Atherosclerosis; Biomarkers; Carotid Artery, Internal; Carotid Stenosis; Case-Control Studies; Female; Humans; Inflammation; Linear Models; Male; Middle Aged; Nitric Oxide Synthase; Severity of Illness Index; Tunica Intima; Tunica Media; Ultrasonography

2007
Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease.
    Journal of the American Society of Nephrology : JASN, 2007, Volume: 18, Issue:5

    Topics: Amidohydrolases; Animals; Arginine; Capillaries; Chronic Disease; Disease Models, Animal; Disease Progression; Fibrosis; Gene Expression Regulation, Enzymologic; Genetic Therapy; Kidney; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta

2007
Oral administration of both tetrahydrobiopterin and L-arginine prevents endothelial dysfunction in rats with chronic renal failure.
    Journal of cardiovascular pharmacology, 2007, Volume: 49, Issue:3

    Topics: Acetylcholine; Administration, Oral; Animals; Aorta; Arginine; Biopterins; Blood Pressure; Calcimycin; Drug Synergism; Drug Therapy, Combination; Endothelium, Vascular; Kidney Failure, Chronic; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxides

2007
A new perspective for the treatment of renal diseases?
    Journal of the American Society of Nephrology : JASN, 2007, Volume: 18, Issue:5

    Topics: Amidohydrolases; Arginine; Cardiovascular Diseases; Chronic Disease; Humans; Kidney Diseases; Nitric Oxide Synthase; Risk Factors

2007
Asymmetric dimethyl-arginine and coronary artery calcification in young adults entering middle age: the CARDIA Study.
    European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 2007, Volume: 14, Issue:2

    Topics: Adult; Analysis of Variance; Arginine; Biomarkers; Calcinosis; Case-Control Studies; Coronary Artery Disease; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Humans; Linear Models; Logistic Models; Male; Middle Aged; Research Design; Risk Factors; Tomography, X-Ray Computed; Treatment Outcome

2007
Asymmetric dimethylarginine predicts cardiovascular events in patients with type 2 diabetes.
    Diabetes care, 2007, Volume: 30, Issue:7

    Topics: Aged; Arginine; C-Reactive Protein; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Middle Aged; Predictive Value of Tests; Prospective Studies; Risk Assessment

2007
Biological variation of asymmetric dimethylarginine and related arginine metabolites and analytical performance goals for their measurement in human plasma.
    European journal of clinical investigation, 2007, Volume: 37, Issue:5

    Topics: Adult; Arginine; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Female; Humans; Male; Middle Aged; Reference Standards; Reproducibility of Results

2007
The inhibitory effect of simvastatin on the ADMA-induced inflammatory reaction is mediated by MAPK pathways in endothelial cells.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 2007, Volume: 85, Issue:1

    Topics: Arginine; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intercellular Adhesion Molecule-1; MAP Kinase Signaling System; NF-kappa B; Nitric Oxide Synthase; Phosphorylation; Protein Kinase Inhibitors; Signal Transduction; Simvastatin; Tumor Necrosis Factor-alpha

2007
Serum leptin, oxidized low density lipoprotein and plasma asymmetric dimethylarginine levels and their relationship with dyslipidaemia in adolescent girls with polycystic ovary syndrome.
    Clinical endocrinology, 2007, Volume: 67, Issue:1

    Topics: Adolescent; Apolipoproteins B; Arginine; Biomarkers; Case-Control Studies; Cholesterol; Cholesterol, LDL; Dyslipidemias; Female; Humans; Leptin; Lipoprotein(a); Lipoproteins, LDL; Lipoproteins, VLDL; Multivariate Analysis; Obesity; Polycystic Ovary Syndrome; Triglycerides

2007
Regulation by DDAH/ADMA pathway of lipopolysaccharide-induced tissue factor expression in endothelial cells.
    Thrombosis and haemostasis, 2007, Volume: 97, Issue:5

    Topics: Amidohydrolases; Arginine; Base Sequence; Cells, Cultured; DNA Primers; Endothelial Cells; Gene Expression; Humans; Lipopolysaccharides; NF-kappa B; Reactive Oxygen Species; RNA, Messenger; Thromboplastin

2007
Flow- and acetylcholine-induced dilatation in small arteries from rats with renovascular hypertension--effect of tempol treatment.
    European journal of pharmacology, 2007, Jul-02, Volume: 566, Issue:1-3

    Topics: Acetylcholine; Animals; Antioxidants; Arginine; Blood Pressure; Coronary Vessels; Cyclic N-Oxides; Hypertension, Renovascular; Male; Mesenteric Arteries; NADPH Oxidases; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Renal Circulation; S-Nitroso-N-Acetylpenicillamine; Spin Labels; Superoxides; Vasodilation; Vasodilator Agents

2007
High-throughput CZE-UV determination of arginine and dimethylated arginines in human plasma.
    Electrophoresis, 2007, Volume: 28, Issue:12

    Topics: Arginine; Electrophoresis, Capillary; Homoarginine; Humans; Plasma; Spectrophotometry, Ultraviolet

2007
Asymmetric dimethylarginine levels in thyroid diseases.
    Journal of endocrinological investigation, 2007, Volume: 30, Issue:3

    Topics: Adult; Arginine; Biomarkers; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Thyroid Diseases

2007
Asymmetric dimethylarginine and hypertension in cerebral small vessel disease.
    Stroke, 2007, Volume: 38, Issue:7

    Topics: Arginine; Blood Pressure; Cerebrovascular Disorders; Enzyme Inhibitors; Humans; Hypertension; Leukoaraiosis; Nitric Oxide; Nitric Oxide Synthase

2007
Increased asymmetric dimethylarginine concentrations in stimulated peripheral blood mononuclear cells.
    Scandinavian journal of immunology, 2007, Volume: 65, Issue:6

    Topics: Arginine; Atorvastatin; Cells, Cultured; Concanavalin A; Enzyme Inhibitors; Heptanoic Acids; Humans; Leukocytes, Mononuclear; Mitogens; Nitric Oxide; Nitric Oxide Synthase; Phytohemagglutinins; Pyrroles; Salicylic Acid

2007
Effects of atorvastatin therapy on hypercholesterolemic rabbits with respect to oxidative stress, nitric oxide pathway and homocysteine.
    Life sciences, 2007, Jun-20, Volume: 81, Issue:2

    Topics: Animals; Arginine; Aryldialkylphosphatase; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Diet; Heptanoic Acids; Homocysteine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipid Peroxidation; Male; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Pyrroles; Rabbits; Thiobarbituric Acid Reactive Substances; Triglycerides

2007
ADMA correlates with portal pressure in patients with compensated cirrhosis.
    European journal of clinical investigation, 2007, Volume: 37, Issue:6

    Topics: Adult; Aged; Arginine; Case-Control Studies; Female; Hepatitis C, Chronic; Humans; Hypertension, Portal; Liver Cirrhosis; Male; Middle Aged; Nitric Oxide; Portal Pressure

2007
Role of asymmetric dimethylarginine in inflammatory reactions by angiotensin II.
    Journal of vascular research, 2007, Volume: 44, Issue:5

    Topics: Amidohydrolases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Arginine; Cell Adhesion; Cells, Cultured; Culture Media, Conditioned; Endothelial Cells; Endothelium, Vascular; Gene Expression Regulation; Humans; Interleukin-8; Losartan; Monocytes; NF-kappa B; Nitrates; Nitric Oxide; Nitrites; Protein-Arginine N-Methyltransferases; Reactive Oxygen Species; Receptors, Interleukin-8B; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha; Umbilical Veins; Vasculitis; Vasodilation

2007
Asymmetric dimethyl L-arginine (ADMA) is a critical regulator of myocardial reperfusion injury.
    Cardiovascular research, 2007, Jul-15, Volume: 75, Issue:2

    Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Endothelium, Vascular; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxidase

2007
Pressure-related increase of asymmetric dimethylarginine caused by hyperbaric oxygen in the rat brain: a possible neuroprotective mechanism.
    Neurochemical research, 2007, Volume: 32, Issue:9

    Topics: Animals; Arginine; Brain; Hyperbaric Oxygenation; Male; Nitrates; Nitrites; Rats; Rats, Sprague-Dawley

2007
Asymmetric dimethylarginine enhances cardiovascular risk prediction in patients with chronic heart failure.
    Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:9

    Topics: Aged; Arginine; Austria; Biomarkers; Disease-Free Survival; Female; Heart Failure; Humans; Male; Natriuretic Peptide, Brain; Peptide Fragments; Prognosis; Prospective Studies; Risk Assessment; Ventricular Dysfunction, Left

2007
Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine predict adverse events in patients undergoing noncardiac surgery.
    Critical care medicine, 2007, Volume: 35, Issue:8

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Female; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Nitric Oxide Synthase; Perioperative Care; Postoperative Complications; Prospective Studies; Risk Assessment; Surgical Procedures, Operative

2007
Aqueous humor levels of asymmetric dimethylarginine (ADMA) are positively associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis.
    The British journal of ophthalmology, 2008, Volume: 92, Issue:1

    Topics: Adult; Aged; Aqueous Humor; Arginine; Biomarkers; Chemokine CCL2; Eye Infections; Humans; Middle Aged; Uveitis

2008
Plasma asymmetric dimethylarginine concentration during the perinatal period.
    Neonatology, 2007, Volume: 92, Issue:1

    Topics: Adult; Arginine; Blood Circulation; Endothelium, Vascular; Female; Humans; Infant, Newborn; Nitric Oxide; Nitric Oxide Synthase; Placental Circulation; Postpartum Period; Pregnancy; Pregnancy Trimester, Third

2007
Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2.
    Circulation research, 2007, Jul-20, Volume: 101, Issue:2

    Topics: Amidohydrolases; Amlodipine; Angiotensin II; Animals; Arginine; Blood Pressure; Coronary Circulation; Coronary Vessels; Creatine Kinase, MB Form; Enzyme Activation; Enzyme Inhibitors; Fibrosis; Heart Diseases; Imidazoles; Mice; Mice, Transgenic; Myocardium; Nitric Oxide; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peptidyl-Dipeptidase A; Pyridines; Time Factors; Tunica Media; Up-Regulation; Vasodilator Agents

2007
[Effect of asymmetric dimethylarginine on the activation of hepatic stellate cells and its mechanism].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2007, Volume: 32, Issue:3

    Topics: Actins; Animals; Arginine; Cells, Cultured; Collagen Type I; Dose-Response Relationship, Drug; Gene Expression; Hepatocytes; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta

2007
Asymmetric dimethylarginine is a marker of poor prognosis and coronary calcium in systemic lupus erythematosus.
    The Journal of rheumatology, 2007, Volume: 34, Issue:7

    Topics: Adult; Antibodies, Antinuclear; Arginine; Biomarkers; Calcinosis; Coronary Angiography; Coronary Disease; Ethnicity; Female; Humans; Lipids; Lupus Erythematosus, Systemic; Male; Maryland; Prognosis; Risk Factors

2007
Soluble RAGE in type 2 diabetes: association with oxidative stress.
    Free radical biology & medicine, 2007, Aug-15, Volume: 43, Issue:4

    Topics: Arginine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Dinoprost; Enzyme-Linked Immunosorbent Assay; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Oxidative Stress; Receptor for Advanced Glycation End Products; Receptors, Immunologic

2007
Determination of dimethylarginine dimethylaminohydrolase activity in the kidney.
    Kidney international, 2007, Volume: 72, Issue:7

    Topics: Amidohydrolases; Animals; Arginine; Citrulline; Kidney; Male; Rats; Rats, Sprague-Dawley; Urea

2007
Plasma adhesion and inflammation markers: asymmetrical dimethyl-L-arginine and secretory phospholipase A2 concentrations before and after laparoscopic gastric banding in morbidly obese patients.
    Obesity surgery, 2007, Volume: 17, Issue:5

    Topics: Adult; Arginine; C-Reactive Protein; Case-Control Studies; Cell Adhesion Molecules; Cohort Studies; Female; Gastroplasty; Group II Phospholipases A2; Humans; Laparoscopy; Male; Obesity, Morbid; Phospholipases A; Phospholipases A2; Weight Loss

2007
Reduced asymmetric dimethylarginine (ADMA) levels mediate in the protection from metabolic syndrome by smoking.
    Atherosclerosis, 2008, Volume: 196, Issue:1

    Topics: Arginine; Female; Humans; Male; Metabolic Syndrome; Middle Aged; Obesity; Smoking

2008
Measurement of arginine derivatives in pediatric patients with chronic kidney disease using high-performance liquid chromatography-tandem mass spectrometry.
    Clinical chemistry and laboratory medicine, 2007, Volume: 45, Issue:10

    Topics: Adolescent; Arginine; Biomarkers; Case-Control Studies; Child; Chromatography, High Pressure Liquid; Female; Humans; Kidney Failure, Chronic; Male; Reproducibility of Results; Sensitivity and Specificity; Siblings; Tandem Mass Spectrometry; Time Factors

2007
Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO.
    Circulation research, 2007, Sep-14, Volume: 101, Issue:6

    Topics: Acetylcholine; Amidohydrolases; Animals; Arginine; Dose-Response Relationship, Drug; Endothelium-Dependent Relaxing Factors; Gene Expression Regulation, Enzymologic; Isoenzymes; Kidney Cortex; Liver; Male; Mesenteric Arteries; Nitric Oxide; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Messenger; RNA, Small Interfering; Time Factors; Vasodilation; Vasodilator Agents

2007
Methylated arginines in stable and acute patients with coronary artery disease before and after percutaneous revascularization.
    International journal of cardiology, 2008, Sep-26, Volume: 129, Issue:2

    Topics: Angioplasty, Balloon, Coronary; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Coronary Artery Disease; Endothelium; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Myocardial Infarction; Nitric Oxide Synthase; Prospective Studies

2008
Presence of asymmetric dimethylarginine gradients across high-grade lesions in patients with coronary artery disease.
    Coronary artery disease, 2007, Volume: 18, Issue:6

    Topics: Aged; Angioplasty, Balloon, Laser-Assisted; Arginine; Atherosclerosis; Biomarkers; Coronary Artery Disease; Coronary Vessels; Endothelium, Vascular; Female; Humans; Male; Middle Aged

2007
Lowering asymmetric dimethylarginine--a new mechanism mediating the renoprotective effects of renin-angiotensin system inhibitors in proteinuric patients?
    Blood purification, 2007, Volume: 25, Issue:4

    Topics: Amidohydrolases; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Biomarkers; Hemorheology; Humans; Kidney; Kidney Failure, Chronic; Proteinuria; Rats; Renin-Angiotensin System; Vasodilation

2007
Impaired vascular nitric oxide bioactivity in women with previous gestational diabetes.
    Wiener klinische Wochenschrift, 2007, Volume: 119, Issue:15-16

    Topics: Adult; Arginine; Body Mass Index; Diabetes Mellitus, Type 2; Diabetes, Gestational; Diabetic Angiopathies; Endothelium, Vascular; Female; Humans; Insulin Resistance; Male; Nitric Oxide; Obesity; Pregnancy; Reference Values; Risk Factors; Sex Factors; Vasoconstriction; Vasodilation

2007
Brachial artery flow-mediated dilation and asymmetrical dimethylarginine in the cardiovascular risk in young Finns study.
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Adult; Arginine; Biomarkers; Brachial Artery; Cardiovascular Diseases; Cross-Sectional Studies; Endothelium, Vascular; Female; Finland; Follow-Up Studies; Hemorheology; Humans; Male; Nitric Oxide Synthase Type III; Oxidative Stress; Risk; Sampling Studies; Vasodilation

2007
Changes of asymmetric dimethylarginine, nitric oxide, tetrahydrobiopterin, and oxidative stress in patients with acute myocardial infarction by medical treatments.
    Clinical hemorheology and microcirculation, 2007, Volume: 37, Issue:3

    Topics: Adult; Aged; Arginine; Biopterins; Case-Control Studies; Drug Therapy; Endothelium, Vascular; Female; Humans; Lipoproteins, LDL; Male; Middle Aged; Myocardial Infarction; Nitric Oxide; Oxidative Stress; Superoxides

2007
Tilarginine in patients with acute myocardial infarction and cardiogenic shock.
    JAMA, 2007, Sep-05, Volume: 298, Issue:9

    Topics: Arginine; Enzyme Inhibitors; Glomerular Filtration Rate; Humans; Myocardial Infarction; Nitric Oxide Synthase; Shock, Cardiogenic; Vasoconstrictor Agents

2007
GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo in
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Oct-15, Volume: 858, Issue:1-2

    Topics: Amidohydrolases; Animals; Arginine; Catalysis; Diabetes Mellitus, Experimental; Dimethylamines; Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Liver; Male; Molecular Structure; Nitrates; Nitrites; Rats; Rats, Wistar; Reproducibility of Results; S-Nitrosothiols

2007
Relations between markers of renal function, coronary risk factors and the occurrence and severity of coronary artery disease.
    Atherosclerosis, 2008, Volume: 197, Issue:2

    Topics: Age Factors; Aged; Arginine; Biomarkers; Cohort Studies; Coronary Artery Disease; Cystatin C; Cystatins; Female; Glomerular Filtration Rate; Homocysteine; Humans; Male; Middle Aged; Renal Insufficiency; Risk Factors

2008
Health-associated reference values for arginine, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) measured with high-performance liquid chromatography.
    Scandinavian journal of clinical and laboratory investigation, 2007, Volume: 67, Issue:8

    Topics: Adult; Age Distribution; Aged; Arginine; Chromatography, High Pressure Liquid; Female; Health; Humans; Male; Middle Aged; Reference Values

2007
Asymmetric dimethylarginine is increased in chronic thromboembolic pulmonary hypertension.
    American journal of respiratory and critical care medicine, 2007, Dec-01, Volume: 176, Issue:11

    Topics: Aged; Arginine; Chronic Disease; Endothelial Cells; Enzyme Inhibitors; Female; Humans; Hypertension, Pulmonary; Kaplan-Meier Estimate; Male; Middle Aged; Nitric Oxide Synthase; Osmolar Concentration; Prognosis; Pulmonary Artery; Severity of Illness Index; Thromboembolism

2007
Unchanged asymmetric dimethylarginine levels in non-diabetic, premenopausal obese women who have common risk factors for cardiovascular disease.
    Endocrine, 2007, Volume: 31, Issue:2

    Topics: Adult; Arginine; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Case-Control Studies; Female; Humans; Insulin Resistance; Middle Aged; Obesity; Overweight; Premenopause; Regression Analysis; Risk Factors

2007
Oxidative stress in cardiovascular disease: successful translation from bench to bedside?
    Circulation, 2007, Sep-18, Volume: 116, Issue:12

    Topics: Arginine; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Endothelium, Vascular; Hemorheology; Humans; Nitric Oxide; Oxidative Stress; Reactive Oxygen Species; Risk; Thrombosis; Vasodilation

2007
Role of DDAH-1 in lipid peroxidation product-mediated inhibition of endothelial NO generation.
    American journal of physiology. Cell physiology, 2007, Volume: 293, Issue:5

    Topics: Aldehydes; Amidohydrolases; Animals; Antioxidants; Arginine; Calcimycin; Calcium; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Glutathione; Humans; Ionophores; Lipid Peroxidation; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Recombinant Proteins

2007
Reduction of asymmetric dimethylarginine involved in the cardioprotective effect of losartan in spontaneously hypertensive rats.
    Canadian journal of physiology and pharmacology, 2007, Volume: 85, Issue:8

    Topics: Animals; Arginine; Blood Pressure; Hypertension; Losartan; Male; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation

2007
Oxidative stress and asymmetric dimethylarginine is independently associated with carotid intima media thickness in peritoneal dialysis patients.
    American journal of nephrology, 2008, Volume: 28, Issue:1

    Topics: Adult; Arginine; Biomarkers; Carotid Artery Diseases; Carotid Artery, Common; Female; Glycation End Products, Advanced; Humans; Kidney Failure, Chronic; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Peritoneal Dialysis; Predictive Value of Tests; Risk Factors; Thiobarbituric Acid Reactive Substances; Tunica Intima; Ultrasonography

2008
Plasma asymmetric dimethylarginine and L-arginine levels in patients with cardiac syndrome X.
    Coronary artery disease, 2007, Volume: 18, Issue:7

    Topics: Aged; Arginine; Coronary Angiography; Coronary Circulation; Exercise Test; Female; Humans; Male; Microvascular Angina; Middle Aged; Myocardium; Nitric Oxide; Perfusion; Pericardium

2007
Asymmetric dimethylarginine plasma concentrations and L-arginine/asymmetric dimethylarginine ratio in patients with slow coronary flow.
    Coronary artery disease, 2007, Volume: 18, Issue:7

    Topics: Adult; Aged; Arginine; Blood Flow Velocity; Cardiovascular Diseases; Case-Control Studies; Chromatography, High Pressure Liquid; Coronary Angiography; Coronary Circulation; Exercise Test; Female; Humans; Male; Middle Aged; Myocardium; Nitric Oxide; Sensitivity and Specificity; Thrombolytic Therapy

2007
Direct analysis of un-derivatized asymmetric dimethylarginine (ADMA) and L-arginine from plasma using mixed-mode ion-exchange liquid chromatography-tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Nov-15, Volume: 859, Issue:2

    Topics: Arginine; Chromatography, Ion Exchange; Humans; Reproducibility of Results; Tandem Mass Spectrometry

2007
Asymmetric dimethylarginine is associated with parameters of glucose metabolism in Caucasian but not in African women from South Africa.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2007, Volume: 115, Issue:9

    Topics: Adult; Arginine; Black People; Body Mass Index; C-Reactive Protein; Cross-Sectional Studies; Fatty Acids, Nonesterified; Female; Glucose; Glucose Tolerance Test; Humans; Insulin; Obesity; Proinsulin; South Africa; White People

2007
Nebivolol reduces asymmetric dimethylarginine in endothelial cells by increasing dimethylarginine dimethylaminohydrolase 2 (DDAH2) expression and activity.
    Pharmacological research, 2007, Volume: 56, Issue:6

    Topics: Adrenergic beta-Antagonists; Amidohydrolases; Antihypertensive Agents; Arginine; Atenolol; Benzopyrans; Cell Line; Endothelial Cells; Ethanolamines; Female; Humans; Male; Nebivolol; Nitric Oxide Synthase Type III; RNA, Messenger

2007
Association of an endogenous inhibitor of nitric oxide synthase with cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.
    Journal of neurosurgery, 2007, Volume: 107, Issue:5

    Topics: Adult; Aged; Arginine; Arnold-Chiari Malformation; Citrulline; Enzyme Inhibitors; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Nitric Oxide Synthase; Nitrites; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2007
Asymmetrical dimethylarginine, inflammatory and metabolic parameters in women with polycystic ovary syndrome before and after metformin treatment.
    The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:1

    Topics: Adult; Androgens; Arginine; Blood Glucose; Body Mass Index; C-Reactive Protein; Cholesterol, LDL; Cross-Sectional Studies; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Polycystic Ovary Syndrome; Statistics, Nonparametric; Triglycerides; Waist-Hip Ratio

2008
Assessment of protein-incorporated arginine methylation in biological specimens by CZE UV-detection.
    Electrophoresis, 2007, Volume: 28, Issue:23

    Topics: Arginine; Blood Proteins; Cells, Cultured; Electrophoresis, Capillary; Endothelium, Vascular; Feasibility Studies; Humans; Methylation; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Proteins; Sensitivity and Specificity; Specimen Handling; Spectrophotometry, Ultraviolet; Umbilical Veins

2007
Reduction of NO- and EDHF-mediated vasodilatation in hypertension: role of asymmetric dimethylarginine.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2007, Volume: 29, Issue:7

    Topics: Animals; Arginine; Biological Factors; Cell Culture Techniques; Down-Regulation; Epoprostenol; Female; Humans; Hypertension; Male; Mesenteric Arteries; Nitric Oxide; Nitric Oxide Synthase; Potassium Channels, Calcium-Activated; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Small-Conductance Calcium-Activated Potassium Channels; Vasodilation

2007
Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals.
    American journal of physiology. Renal physiology, 2008, Volume: 294, Issue:2

    Topics: Animals; Arginine; Blood Pressure; Disease Models, Animal; Diuresis; Enzyme Inhibitors; Hydronephrosis; Hypertension; Indazoles; Kidney; Kidney Cortex; Kidney Tubules, Proximal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Sodium Chloride, Dietary; Ureteral Obstruction

2008
A new selective pre-column ninhydrin-based derivatization for a RP-HPLC determination of plasma asymmetric dimethyl-L-arginine (ADMA) by fluorescence detection.
    Amino acids, 2008, Volume: 34, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Chromatography, High Pressure Liquid; Female; Fluorescence; Humans; Male; Middle Aged; Ninhydrin; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Time Factors

2008
Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation.
    Stroke, 2008, Volume: 39, Issue:1

    Topics: Acetylcholine; Amidohydrolases; Animals; Aorta; Arginine; Arterioles; Cardiovascular Diseases; Carotid Arteries; Cerebrovascular Circulation; Endothelium, Vascular; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Vasodilator Agents

2008
Asymmetric dimethylarginine and impaired cardiovascular healing.
    Journal of thrombosis and thrombolysis, 2009, Volume: 27, Issue:2

    Topics: Apoptosis; Arginine; Cardiovascular Diseases; Humans; Kidney Diseases; Myocardial Ischemia; Nitric Oxide; Prognosis; Regeneration; Stem Cells; Treatment Outcome

2009
Simultaneous assessment of endothelial function, nitric oxide synthase activity, nitric oxide-mediated signaling, and oxidative stress in individuals with and without hypercholesterolemia.
    Clinical chemistry, 2008, Volume: 54, Issue:2

    Topics: Adolescent; Adult; Aged; Arginine; Cyclic GMP; Dinoprost; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Male; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Sex Factors

2008
Methylglyoxal and methylglyoxal-arginine adducts do not directly inhibit endothelial nitric oxide synthase.
    Annals of the New York Academy of Sciences, 2008, Volume: 1126

    Topics: Anthracenes; Arginine; Endothelium, Vascular; Enzyme Inhibitors; Humans; Nitric Oxide Synthase Type III; Propane; Pyruvaldehyde; Umbilical Veins

2008
Effect of angiotensin-converting enzyme inhibitor on serum asymmetric dimethylarginine and coronary circulation in patients with type 2 diabetes mellitus.
    International journal of cardiology, 2009, Feb-20, Volume: 132, Issue:2

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Arginine; Coronary Circulation; Diabetes Mellitus, Type 2; Female; Humans; Male; Thiazepines

2009
Urotensin II and cardiomyopathy in end-stage renal disease.
    Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:2

    Topics: Adult; Aged; Arginine; Cardiomyopathies; Cardiotonic Agents; Echocardiography; Female; Heart Atria; Humans; Kidney Failure, Chronic; Male; Medical Records; Middle Aged; Multivariate Analysis; Nitric Oxide; Sympathetic Nervous System; Urotensins; Ventricular Function, Left

2008
Contrast-induced nephropathy and mortality: possible crucial role of asymmetric dimethylarginine.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2007, Volume: 8, Issue:12

    Topics: Acetylcysteine; Angioplasty, Balloon, Coronary; Antioxidants; Arginine; Biomarkers; Contrast Media; Coronary Angiography; Humans; Kidney Diseases; Nitric Oxide

2007
Elevated asymmetric dimethylarginine concentrations precede clinical preeclampsia, but not pregnancies with small-for-gestational-age infants.
    American journal of obstetrics and gynecology, 2008, Volume: 198, Issue:1

    Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Female; Humans; Infant, Newborn; Infant, Small for Gestational Age; Pre-Eclampsia; Predictive Value of Tests; Pregnancy; Pregnancy Outcome; Probability; Reference Values; Risk Assessment; Sampling Studies; Sensitivity and Specificity

2008
Dysfunction of endothelial NO system originated from homocysteine-induced aberrant methylation pattern in promoter region of DDAH2 gene.
    Chinese medical journal, 2007, Dec-05, Volume: 120, Issue:23

    Topics: Amidohydrolases; Arginine; Cells, Cultured; DNA Methylation; Homocysteine; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Promoter Regions, Genetic

2007
ADMA correlates with portal pressure in patients with compensated cirrhosis by Vizzutti et al. Eur J Clin Invest 2007; 37: 509-15.
    European journal of clinical investigation, 2008, Volume: 38, Issue:1

    Topics: Arginine; Humans; Liver Cirrhosis; Nitric Oxide; Portal Pressure

2008
Elevated asymmetric dimethylarginine (ADMA) and inverse correlation between circulating ADMA and glomerular filtration rate in children with sporadic focal segmental glomerulosclerosis (FSGS).
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:2

    Topics: Adolescent; Arginine; Child; Child, Preschool; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Humans; Nitric Oxide

2008
Polycystic ovarian syndrome, biomarkers, and metformin: research, risk, and reality.
    The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:1

    Topics: Arginine; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Risk Factors

2008
Determination of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, in umbilical blood.
    Metabolism: clinical and experimental, 2008, Volume: 57, Issue:2

    Topics: Adolescent; Adult; Arginine; Child; Child, Preschool; Enzyme Inhibitors; Female; Fetal Blood; Humans; Infant, Newborn; Infant, Premature; Linear Models; Male; Middle Aged; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Pregnancy; Umbilical Veins

2008
ADMA levels correlate with proteinuria, secondary amyloidosis, and endothelial dysfunction.
    Journal of the American Society of Nephrology : JASN, 2008, Volume: 19, Issue:2

    Topics: Adult; Amyloidosis; Arginine; Chronic Disease; Endothelium; Female; Glomerulonephritis; Humans; Male; Multivariate Analysis; Predictive Value of Tests; Proteinuria; Risk Factors

2008
Human recombinant erythropoietin augments serum asymmetric dimethylarginine concentrations but does not compromise nitric oxide generation in mice.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:5

    Topics: Amidohydrolases; Animals; Arginine; Base Sequence; Cells, Cultured; DNA Primers; Endothelial Cells; Epoetin Alfa; Erythropoietin; Humans; Kidney; Kidney Failure, Chronic; Liver; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase Type II; Recombinant Proteins; Up-Regulation; Vascular Diseases

2008
Asymmetric dimethylarginine and lipid peroxidation products in early autosomal dominant polycystic kidney disease.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2008, Volume: 51, Issue:2

    Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Cross-Sectional Studies; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Humans; Linoleic Acids; Lipid Peroxidation; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Polycystic Kidney, Autosomal Dominant

2008
Response of asymmetric dimethylarginine to hemodialysis-associated hypotension in end-stage renal disease patients.
    Nephron. Clinical practice, 2008, Volume: 108, Issue:2

    Topics: Aged; Arginine; Biomarkers; Blood Pressure Determination; Case-Control Studies; Female; Follow-Up Studies; Humans; Hypotension; Kidney Failure, Chronic; Male; Middle Aged; Probability; Reference Values; Renal Dialysis; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Treatment Outcome

2008
Dimethylarginine dimethylaminohydrolase overexpression enhances insulin sensitivity.
    Arteriosclerosis, thrombosis, and vascular biology, 2008, Volume: 28, Issue:4

    Topics: Amidohydrolases; Animals; Arginine; Female; Gene Expression; Glucose Tolerance Test; Glycogen; Humans; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Skeletal; Nitric Oxide; Recombinant Proteins

2008
Effect of telmisartan on nitric oxide--asymmetrical dimethylarginine system: role of angiotensin II type 1 receptor gamma and peroxisome proliferator activated receptor gamma signaling during endothelial aging.
    Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:3

    Topics: Acrylates; Amidohydrolases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Anilides; Arginine; Benzimidazoles; Benzoates; Cells, Cultured; Cellular Senescence; Down-Regulation; Endothelium, Vascular; Humans; Imidazoles; Nitric Oxide; Oxidative Stress; PPAR gamma; Receptor, Angiotensin, Type 1; Signal Transduction; Telmisartan; Thiophenes; Up-Regulation

2008
First-trimester uterine artery resistance and maternal serum concentration of asymmetric dimethylarginine.
    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2008, Volume: 31, Issue:2

    Topics: Adult; Arginine; Arteries; Blood Pressure; Female; Humans; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, First; Ultrasonography, Doppler; Uterus; Vascular Resistance

2008
Increased plasma asymmetric dimethylarginine (ADMA) levels in retinal venous occlusive disease.
    Clinical chemistry and laboratory medicine, 2008, Volume: 46, Issue:3

    Topics: Aged; Arginine; Case-Control Studies; Cohort Studies; Cysteine; Female; Humans; Male; Middle Aged; Retinal Vein Occlusion; Risk Factors

2008
Impact of asymmetric dimethylarginine on mortality after acute myocardial infarction.
    Arteriosclerosis, thrombosis, and vascular biology, 2008, Volume: 28, Issue:5

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Predictive Value of Tests; Prognosis; Prospective Studies; Regression Analysis

2008
Metformin and oral contraceptive treatments reduced circulating asymmetric dimethylarginine (ADMA) levels in patients with polycystic ovary syndrome (PCOS).
    Atherosclerosis, 2008, Volume: 200, Issue:2

    Topics: Adult; Androgens; Arginine; Body Mass Index; Case-Control Studies; Contraceptives, Oral; Cyproterone Acetate; Ethinyl Estradiol; Female; Gonadotropins; Humans; Insulin Resistance; Metformin; Polycystic Ovary Syndrome; Time Factors

2008
Involvement of the endothelial DDAH/ADMA pathway in nitroglycerin tolerance: the role of ALDH-2.
    Life sciences, 2008, Mar-26, Volume: 82, Issue:13-14

    Topics: Acetylcysteine; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Amidohydrolases; Arginine; Cell Line; Cyclic GMP; Drug Tolerance; Endothelial Cells; Humans; Lipid Peroxides; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitroglycerin; Oxidative Stress; Reactive Oxygen Species

2008
Asymmetric dimethylarginine independently predicts fatal and nonfatal myocardial infarction and stroke in women: 24-year follow-up of the population study of women in Gothenburg.
    Arteriosclerosis, thrombosis, and vascular biology, 2008, Volume: 28, Issue:5

    Topics: Adult; Arginine; Biomarkers; Cohort Studies; Female; Follow-Up Studies; Homocysteine; Humans; Longitudinal Studies; Middle Aged; Myocardial Infarction; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Factors; Stroke; Sweden

2008
Effects of moderate hyperhomocysteinaemia induced by 4 weeks methionine-enriched diet on metabolite profile and mesenteric artery function in rats.
    The British journal of nutrition, 2008, Volume: 99, Issue:5

    Topics: Animals; Arginine; Biomarkers; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Diet; Homocysteine; Hyperhomocysteinemia; Male; Mesenteric Arteries; Methionine; Rats; Rats, Wistar; Vasodilation

2008
Endothelin-1 and asymmetric dimethylarginine in children with left-to-right shunt after intracardiac repair.
    Clinical research in cardiology : official journal of the German Cardiac Society, 2008, Volume: 97, Issue:6

    Topics: Adolescent; Adult; Arginine; Biomarkers; Cardiopulmonary Bypass; Child; Child, Preschool; Endothelin-1; Female; Humans; Hypertension, Pulmonary; Infant; Male; Nitric Oxide Synthase; Pancreatitis-Associated Proteins; Postoperative Complications; Prospective Studies; Statistics, Nonparametric; Time Factors; Treatment Outcome; Young Adult

2008
[Differentiation of 2 endothelial progenitor cells in vitro and inhibitory effect of asymmetric dimethylarginine on its proliferation].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2008, Volume: 33, Issue:2

    Topics: Arginine; Cell Differentiation; Cell Proliferation; Cells, Cultured; Culture Media; Depression, Chemical; Endothelial Cells; Fetal Blood; Humans; Leukocytes, Mononuclear; Stem Cells

2008
Gene transfer of dimethylarginine dimethylaminohydrolase-2 improves the impairments of DDAH/ADMA/NOS/NO pathway in endothelial cells induced by lysophosphatidylcholine.
    European journal of pharmacology, 2008, Apr-14, Volume: 584, Issue:1

    Topics: Amidohydrolases; Arginine; Cell Line, Transformed; Cell Survival; Endothelial Cells; Enzyme Inhibitors; Enzyme Repression; Humans; Lysophosphatidylcholines; Nitric Oxide; Nitric Oxide Synthase; Signal Transduction; Transcription, Genetic; Transfection

2008
Anti-hypertensive effects of Rosuvastatin are associated with decreased inflammation and oxidative stress markers in hypertensive rats.
    Free radical research, 2008, Volume: 42, Issue:3

    Topics: Animals; Antihypertensive Agents; Arginine; Blood Pressure; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-4; Male; NADPH Oxidases; Oxidative Stress; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Rosuvastatin Calcium; Sulfonamides

2008
Asymmetric dimethylarginine and cardiac allograft vasculopathy progression: modulation by sirolimus.
    Transplantation, 2008, Mar-27, Volume: 85, Issue:6

    Topics: Adult; Aged; Arginine; Biomarkers; Heart Transplantation; Humans; Hyperplasia; Immunosuppressive Agents; Longitudinal Studies; Middle Aged; Sirolimus; Transplantation, Homologous; Tunica Intima; Ultrasonography; Vascular Diseases

2008
Asymmetrical dimethylarginine level in atrial fibrillation.
    Acta cardiologica, 2008, Volume: 63, Issue:1

    Topics: Acute Disease; Arginine; Atrial Fibrillation; Chromatography, High Pressure Liquid; Chronic Disease; Humans; Middle Aged

2008
Plasma concentrations of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell patients but do not increase further during painful crisis.
    American journal of hematology, 2008, Volume: 83, Issue:7

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Arginine; Child; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Stereoisomerism

2008
Asymmetric dimethylarginine inhibits HSP90 activity in pulmonary arterial endothelial cells: role of mitochondrial dysfunction.
    American journal of physiology. Cell physiology, 2008, Volume: 294, Issue:6

    Topics: Adenosine Triphosphate; Animals; Arginine; Cells, Cultured; HSP90 Heat-Shock Proteins; Humans; Ion Channels; Mitochondria; Mitochondrial Proteins; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Protein Binding; Protein Transport; Pulmonary Artery; Recombinant Proteins; Sheep; Signal Transduction; Superoxides; Tyrosine; Uncoupling Protein 2

2008
Alpha-defensin-like product and asymmetric dimethylarginine increase in mesenteric lymph after hemorrhage in anesthetized rat.
    Shock (Augusta, Ga.), 2008, Volume: 30, Issue:4

    Topics: alpha-Defensins; Anesthesia; Animals; Antimicrobial Cationic Peptides; Arginine; Enzyme-Linked Immunosorbent Assay; Hemorrhage; Inflammation; Intestinal Mucosa; Lymph Nodes; Male; Phospholipases A2; Rats; Rats, Sprague-Dawley; Time Factors

2008
[Does tobacco smoke influence the concentration of asymmetric dimethylarginine (ADMA) in healthy males plasma?].
    Przeglad lekarski, 2007, Volume: 64, Issue:10

    Topics: Adolescent; Adult; Arginine; Cotinine; Humans; Male; Middle Aged; Smoking; Surveys and Questionnaires; Tobacco Smoke Pollution

2007
Role of endogenous nitric oxide synthase inhibitor in gastric mucosal injury.
    Canadian journal of physiology and pharmacology, 2008, Volume: 86, Issue:3

    Topics: Amidohydrolases; Animals; Arginine; Campylobacter jejuni; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Ethanol; Gastric Acid; Gastric Mucosa; Helicobacter pylori; Humans; Indomethacin; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Stomach Diseases; Tumor Necrosis Factor-alpha

2008
Putative role of asymmetric dimethylarginine in microvascular disease of kidney and heart in hypertensive patients.
    American journal of hypertension, 2008, Volume: 21, Issue:6

    Topics: Aged; Arginine; Carotid Arteries; Echocardiography; Female; Glomerular Filtration Rate; Heart Diseases; Humans; Hypertension; Male; Middle Aged; Renal Insufficiency

2008
Disturbed angiogenesis in systemic sclerosis: high levels of soluble endoglin.
    Rheumatology (Oxford, England), 2008, Volume: 47, Issue:7

    Topics: Adult; Aged; Antigens, CD; Arginine; Biomarkers; Cross-Sectional Studies; Endoglin; Female; Humans; Male; Middle Aged; Neovascularization, Pathologic; Receptors, Cell Surface; Scleroderma, Systemic; Solubility; Vascular Endothelial Growth Factor A

2008
The homocysteine paradox.
    Arteriosclerosis, thrombosis, and vascular biology, 2008, Volume: 28, Issue:6

    Topics: Animals; Arginine; Cardiovascular Diseases; Cystatin C; Cystatins; Disease Models, Animal; Folic Acid; Glomerular Filtration Rate; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Diseases; Risk Factors; Vitamin B 12; Vitamin B 6

2008
Effect of acute variations of insulin and glucose on plasma concentrations of asymmetric dimethylarginine in young people with Type 1 diabetes.
    Clinical science (London, England : 1979), 2008, Volume: 115, Issue:12

    Topics: Adolescent; Arginine; Biomarkers; Blood Glucose; Creatinine; Diabetes Mellitus, Type 1; Drug Administration Schedule; Female; Glucose Clamp Technique; Humans; Insulin; Male; Phenylalanine; Valine; Young Adult

2008
Glomerular filtration and coronary flow: is ADMA the faucet regulating both?
    American journal of hypertension, 2008, Volume: 21, Issue:6

    Topics: Arginine; Coronary Circulation; Glomerular Filtration Rate; Humans; Nitric Oxide Synthase

2008
Oxidative stress and asymmetric dimethylarginine are associated with cardiovascular complications in hemodialysis patients: improvements by L-arginine intake.
    Kidney & blood pressure research, 2008, Volume: 31, Issue:3

    Topics: Aged; Arginine; Cardiovascular Diseases; Case-Control Studies; Homocysteine; Humans; Kidney Failure, Chronic; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Peroxidase; Renal Dialysis; Risk Factors

2008
Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension.
    Circulation, 2008, Jun-10, Volume: 117, Issue:23

    Topics: AC133 Antigen; Aged; Antigens, CD; Antigens, CD34; Arginine; Cells, Cultured; Cyclic GMP; Down Syndrome; Eisenmenger Complex; Endothelium, Vascular; Exercise; Female; Flow Cytometry; Glycoproteins; Hematopoietic Stem Cells; Humans; Hypertension, Pulmonary; Inflammation Mediators; Male; Middle Aged; Natriuretic Peptide, Brain; Peptides; Piperazines; Pulmonary Artery; Purines; Sildenafil Citrate; Stem Cells; Sulfones; Vascular Endothelial Growth Factor Receptor-2; Vasodilator Agents

2008
Asymmetric dimethylarginine (ADMA) is tightly correlated with growth in juveniles without correlations to obesity related disorders.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2008, Volume: 116, Issue:9

    Topics: Adolescent; Alkaline Phosphatase; Arginine; Atherosclerosis; Blood Pressure; Body Mass Index; Child; Female; Growth; Humans; Male; Obesity; Reference Values; Regression Analysis; Young Adult

2008
Evaluation of the relationship between flow-mediated vasodilation and some atherogenic risk markers in severe hypercholesterolemia.
    Folia medica, 2008, Volume: 50, Issue:1

    Topics: Arginine; Atherosclerosis; Biomarkers; Cholesterol, LDL; Humans; Hypercholesterolemia; Risk Factors; Vasodilation

2008
Asymmetric dimethylarginine (ADMA) has a role in regulating systemic vascular tone in young healthy subjects: the cardiovascular risk in young Finns study.
    American journal of hypertension, 2008, Volume: 21, Issue:8

    Topics: Adult; Arginine; Blood Pressure; Cardiovascular Diseases; Female; Finland; Humans; Kidney; Lipids; Male; Nitric Oxide; Risk Factors; Vascular Resistance; Vasoconstriction; Young Adult

2008
Symmetric dimethylarginine is an independent predictor of intradialytic hypotension.
    American journal of hypertension, 2008, Volume: 21, Issue:8

    Topics: Aged; Arginine; Biomarkers; Blood Pressure; Female; Humans; Hypotension; Kidney Failure, Chronic; Male; Middle Aged; omega-N-Methylarginine; Predictive Value of Tests; Renal Dialysis

2008
Regulation of eNOS-derived superoxide by endogenous methylarginines.
    Biochemistry, 2008, Jul-08, Volume: 47, Issue:27

    Topics: Arginine; Biopterins; Electron Spin Resonance Spectroscopy; Heme; Humans; NADP; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Superoxides

2008
Coronary artery calcification, ADMA, and insulin resistance in CKD patients.
    Clinical journal of the American Society of Nephrology : CJASN, 2008, Volume: 3, Issue:5

    Topics: Aged; Arginine; Calcinosis; Case-Control Studies; Chronic Disease; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Insulin Resistance; Kidney Diseases; Male; Middle Aged; Risk Assessment; Severity of Illness Index; Tomography, X-Ray Computed

2008
[Asymmetric dimethil-arginine (ADMA) as a link between insulin resistance and atherosclerosis].
    Ideggyogyaszati szemle, 2008, May-30, Volume: 61, Issue:5-6

    Topics: Adult; Arginine; Atherosclerosis; Cardiovascular Diseases; Carotid Stenosis; Chromatography; Enzyme Inhibitors; Female; Homocysteine; Humans; Insulin Resistance; Linear Models; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Risk Factors; Tunica Intima; Tunica Media; Ultrasonography, Doppler, Color

2008
Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:2

    Topics: Amidohydrolases; Animals; Arginine; Carotid Arteries; Cell Line; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; RNA, Messenger; Vasodilation; Vasodilator Agents

2008
The relationship among asymmetric dimethylarginine (ADMA) levels, residual renal function, and left ventricular hypertrophy in continuous ambulatory peritoneal dialysis patients.
    Renal failure, 2008, Volume: 30, Issue:4

    Topics: Adult; Analysis of Variance; Arginine; Biomarkers; Case-Control Studies; Creatinine; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Hypertrophy, Left Ventricular; Incidence; Kidney Failure, Chronic; Kidney Function Tests; Male; Middle Aged; Multivariate Analysis; Peritoneal Dialysis, Continuous Ambulatory; Probability; Reference Values; Regression Analysis; Risk Assessment; Severity of Illness Index; Survival Rate; Treatment Outcome; Ultrasonography

2008
Plasma asymmetric dimethylarginine and cardiovascular events in patients with acute decompensated heart failure.
    Translational research : the journal of laboratory and clinical medicine, 2008, Volume: 152, Issue:1

    Topics: Aged; Arginine; Austria; Cohort Studies; Female; Heart Failure; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Prospective Studies; Risk Assessment; Ventricular Dysfunction, Left

2008
Differential long-term effects of carvedilol on proinflammatory and antiinflammatory cytokines, asymmetric dimethylarginine, and left ventricular function in patients with heart failure.
    Journal of cardiovascular pharmacology, 2008, Volume: 52, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Arginine; Carbazoles; Carvedilol; Cytokines; Drug Administration Schedule; Female; Heart Failure; Humans; Interleukin-10; Interleukin-18; Male; Propanolamines; Prospective Studies; Ventricular Function, Left

2008
EPO induces rise in serum ADMA but does not prevent the increase in NO release: the likely involvement of HO-1.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:9

    Topics: Animals; Apoptosis; Arginine; Endothelium, Vascular; Epoetin Alfa; Erythropoietin; Heme Oxygenase-1; Humans; Kidney Failure, Chronic; Nitric Oxide; Nitric Oxide Synthase; Recombinant Proteins; Renal Dialysis

2008
Determination of dimethylarginine levels in rats using HILIC-MS/MS: an in vivo microdialysis study.
    Journal of separation science, 2008, Volume: 31, Issue:13

    Topics: Animals; Arginine; Chromatography, Liquid; Enzyme Inhibitors; Microdialysis; Nitric Oxide Synthase; Prefrontal Cortex; Rats; Rats, Wistar; Reference Standards; Tandem Mass Spectrometry

2008
Asymmetrical dimethylarginine is increased in plasma and decreased in cerebrospinal fluid of patients with Alzheimer's disease.
    Dementia and geriatric cognitive disorders, 2008, Volume: 26, Issue:1

    Topics: Aged; Alzheimer Disease; Arginine; Biomarkers; Body Mass Index; Case-Control Studies; Cognition Disorders; Female; Humans; Hypercholesterolemia; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Risk Factors

2008
[The effect of plasma asymmetric dimethylarginine (ADMA) level and L-arginine/ADMA ratio on the development of coronary collaterals].
    Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2008, Volume: 36, Issue:3

    Topics: Arginine; Chromatography, High Pressure Liquid; Collateral Circulation; Confidence Intervals; Coronary Stenosis; Female; Humans; Logistic Models; Male; Middle Aged; Nitric Oxide Synthase; Odds Ratio; Risk Factors

2008
Association of asymmetric dimethylarginine with sickle cell disease-related pulmonary hypertension.
    Haematologica, 2008, Volume: 93, Issue:9

    Topics: Adult; Anemia, Sickle Cell; Arginine; Biomarkers; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged

2008
Evaluation of mobile phase, ion pairing, and temperature influence on an HILIC-MS/MS method for L-arginine and its dimethylated derivatives detection.
    Journal of separation science, 2008, Volume: 31, Issue:13

    Topics: Acrylonitrile; Arginine; Blood Chemical Analysis; Chromatography, Liquid; Indicators and Reagents; Reference Standards; Tandem Mass Spectrometry; Temperature; Trifluoroacetic Acid

2008
Relationship between serum pre-B cell colony-enhancing factor/visfatin and atherosclerotic parameters in chronic hemodialysis patients.
    American journal of nephrology, 2009, Volume: 29, Issue:1

    Topics: Aged; Aorta; Arginine; Arteries; Atherosclerosis; B-Lymphocytes; Body Mass Index; C-Reactive Protein; Chronic Disease; Female; Humans; Male; Middle Aged; Nicotinamide Phosphoribosyltransferase; Renal Dialysis

2009
Down-regulation of asymmetric arginine methylation during replicative and H2O2-induced premature senescence in WI-38 human diploid fibroblasts.
    Journal of biochemistry, 2008, Volume: 144, Issue:4

    Topics: Arginine; Cell Line; Cell Proliferation; Cellular Senescence; Down-Regulation; Fibroblasts; HeLa Cells; Humans; Hydrogen Peroxide; Methylation; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases

2008
Asymmetric dimethylarginine, oxidative stress, and vascular nitric oxide synthase in essential hypertension.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 296, Issue:2

    Topics: Adult; Arginine; Blood Pressure; Buttocks; Endothelium-Dependent Relaxing Factors; Female; Humans; Hypertension; Linoleic Acids; Lipid Peroxidation; Male; Microvessels; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Subcutaneous Tissue; Up-Regulation; Vasodilation; Young Adult

2009
Obstructive sleep apnoea syndrome is associated with enhanced sub-clinical inflammation and asymmetric dimethyl-arginine levels in hypertensives.
    Journal of human hypertension, 2009, Volume: 23, Issue:1

    Topics: Adult; Arginine; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases; Cross-Sectional Studies; Endothelium, Vascular; Female; Humans; Hypertension; Inflammation; Interleukin-18; Interleukin-6; Male; Middle Aged; Risk Factors; Severity of Illness Index; Sleep Apnea, Obstructive; Tumor Necrosis Factor-alpha

2009
Determination of protein-incorporated methylated arginine reference values in healthy subjects whole blood and evaluation of factors affecting protein methylation.
    Clinical biochemistry, 2008, Volume: 41, Issue:14-15

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Female; Health; Humans; Male; Methylation; Middle Aged; omega-N-Methylarginine; Proteins; Reference Values; Regression Analysis

2008
Plasma level of asymmetric dimethylarginine (ADMA) as a predictor of carotid intima-media thickness progression: six-year prospective study using carotid ultrasonography.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2008, Volume: 31, Issue:6

    Topics: Aged; Arginine; Atherosclerosis; Carotid Arteries; Disease Progression; Female; Humans; Linear Models; Male; Middle Aged; Prospective Studies; Tunica Intima; Tunica Media; Ultrasonography

2008
L-Arginine is related to endothelium-dependent vasodilation in resistance and conduit arteries in divergent ways-The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study.
    Atherosclerosis, 2009, Volume: 203, Issue:2

    Topics: Aged; Arginine; Arteries; Endothelium; Endothelium-Dependent Relaxing Factors; Female; Humans; Linear Models; Male; Nitric Oxide; Prospective Studies; Vasodilation; Vasodilator Agents

2009
Decrease in the synthesis and release of calcitonin gene-related peptide in dorsal root ganglia of spontaneously hypertensive rat: role of nitric oxide synthase inhibitors.
    European journal of pharmacology, 2008, Oct-31, Volume: 596, Issue:1-3

    Topics: Animals; Arginine; Blood Pressure; Calcitonin Gene-Related Peptide; Cells, Cultured; Ganglia, Spinal; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroso Compounds; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Species Specificity

2008
Increased asymmetric dimethylarginine levels in young men with familial Mediterranean fever (FMF): is it early evidence of interaction between inflammation and endothelial dysfunction in FMF?
    The Journal of rheumatology, 2008, Volume: 35, Issue:10

    Topics: Adult; Arginine; C-Reactive Protein; Case-Control Studies; Colchicine; Endothelium, Vascular; Familial Mediterranean Fever; Humans; Inflammation; Lipids; Male; Young Adult

2008
Development and validation of a fast quantitative method for plasma dimethylarginines analysis using liquid chromatography-tandem mass spectrometry.
    Clinical biochemistry, 2008, Volume: 41, Issue:16-17

    Topics: Arginine; Calibration; Chromatography, Liquid; Humans; Quality Control; Reproducibility of Results; Tandem Mass Spectrometry

2008
Blood content of asymmetric dimethylarginine: new insights into its dysregulation in renal disease.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:2

    Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Erythrocytes; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Peptide Hydrolases; Plasma

2009
Relationship of asymmetric dimethylarginine with flow-mediated dilatation in subjects with newly detected severe hypercholesterolemia.
    Clinical physiology and functional imaging, 2008, Volume: 28, Issue:6

    Topics: Adult; Arginine; Biomarkers; Brachial Artery; Case-Control Studies; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Lipids; Male; Regional Blood Flow; Severity of Illness Index; Ultrasonography; Up-Regulation; Vasodilation

2008
Nitric oxide upregulates dimethylarginine dimethylaminohydrolase-2 via cyclic GMP induction in endothelial cells.
    Hypertension (Dallas, Tex. : 1979), 2008, Volume: 52, Issue:5

    Topics: Amidohydrolases; Animals; Arginine; Carbazoles; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Male; Natriuretic Peptide, C-Type; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitro Compounds; omega-N-Methylarginine; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Up-Regulation

2008
Plasma asymmetric dimethylarginine, L-arginine and left ventricular structure and function in a community-based sample.
    Atherosclerosis, 2009, Volume: 204, Issue:1

    Topics: Aged; Arginine; Female; Heart Atria; Heart Ventricles; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Myocardial Contraction; Obesity; Population Surveillance; Risk Assessment; Risk Factors; Ultrasonography; Ventricular Dysfunction, Left

2009
Elevated plasma adiponectin and decreased plasma homocysteine and asymmetric dimethylarginine in children with type 1 diabetes.
    Scandinavian journal of clinical and laboratory investigation, 2009, Volume: 69, Issue:1

    Topics: Adiponectin; Adolescent; Arginine; C-Reactive Protein; Case-Control Studies; Child; Child, Preschool; Confidence Intervals; Diabetes Mellitus, Type 1; Female; Homocysteine; Humans; Intercellular Adhesion Molecule-1; Male; Statistics, Nonparametric

2009
ADMA impairs nitric oxide-mediated arteriolar function due to increased superoxide production by angiotensin II-NAD(P)H oxidase pathway.
    Hypertension (Dallas, Tex. : 1979), 2008, Volume: 52, Issue:5

    Topics: Acetophenones; Angiotensin II; Animals; Arginine; Arterioles; Enzyme Inhibitors; Losartan; Male; Muscle, Skeletal; NADPH Oxidases; Nitric Oxide; Oxidative Stress; Quinapril; Rats; Rats, Wistar; Signal Transduction; Superoxides; Tetrahydroisoquinolines; Vasoconstriction; Vasodilation

2008
Endogenous nitric oxide synthase inhibitors, arterial hemodynamics, and subclinical vascular disease: the PREVENCION Study.
    Hypertension (Dallas, Tex. : 1979), 2008, Volume: 52, Issue:6

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Blood Flow Velocity; Blood Pressure; Carotid Artery Diseases; Female; Humans; Hypertension; Male; Middle Aged; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Predictive Value of Tests; Prognosis; Pulsatile Flow; Regression Analysis; Risk Factors

2008
Modulation of Rac1 activity by ADMA/DDAH regulates pulmonary endothelial barrier function.
    Molecular biology of the cell, 2009, Volume: 20, Issue:1

    Topics: Adherens Junctions; Amidohydrolases; Animals; Antigens, CD; Arginine; Cadherins; cdc42 GTP-Binding Protein; Cell Adhesion Molecules; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases; Cytoskeleton; Endothelium; Enzyme Activation; Enzyme Inhibitors; Isoenzymes; Lung; Mice; Mice, Knockout; Microfilament Proteins; Nitric Oxide; Nitric Oxide Synthase; Permeability; Phosphoproteins; rac1 GTP-Binding Protein; Reactive Oxygen Species; rhoA GTP-Binding Protein; Swine

2009
Asymmetric dimethylarginine and coronary collateral vessel development.
    Coronary artery disease, 2008, Volume: 19, Issue:7

    Topics: Adult; Aged; Arginine; Biomarkers; Collateral Circulation; Coronary Angiography; Coronary Circulation; Coronary Stenosis; Female; Humans; Male; Middle Aged; Odds Ratio

2008
Relation between asymmetric dimethylarginine (ADMA) and hearing loss in patients with renal impairment.
    Renal failure, 2008, Volume: 30, Issue:9

    Topics: Adult; Arginine; C-Reactive Protein; Case-Control Studies; Creatinine; Female; Hearing Loss, Sensorineural; Humans; Lipids; Male; Middle Aged; Renal Insufficiency, Chronic; Risk Factors

2008
Asymmetric dimethylarginine levels decrease because of insulin infusion: is it an unexpected finding?
    Metabolism: clinical and experimental, 2008, Volume: 57, Issue:11

    Topics: Arginine; Humans; Insulin; Insulin Resistance

2008
Increased plasma levels of asymmetric dimethylarginine and soluble CD40 ligand in patients with sleep apnea.
    Respiration; international review of thoracic diseases, 2009, Volume: 77, Issue:1

    Topics: Adult; Arginine; Atherosclerosis; Cardiovascular Diseases; Case-Control Studies; CD40 Ligand; Endothelin-1; Humans; Male; Middle Aged; Risk Factors; Sleep Apnea, Obstructive

2009
Unchanged plasma levels of dimethylarginines and nitric oxide in chronic hepatitis C.
    Scandinavian journal of gastroenterology, 2009, Volume: 44, Issue:2

    Topics: Adult; Antiviral Agents; Arginine; Case-Control Studies; Female; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Nitric Oxide; Polyethylene Glycols; Recombinant Proteins; Ribavirin

2009
Smoker's paradox in heart failure: might asymmetric dimethylarginine be the possible explanation?
    European heart journal, 2008, Volume: 29, Issue:23

    Topics: Arginine; Cardiovascular Diseases; Heart Failure; Hospital Mortality; Humans; Smoking

2008
Plasma levels of asymmetric dimethylarginine in cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy.
    Cerebrovascular diseases (Basel, Switzerland), 2008, Volume: 26, Issue:6

    Topics: Adult; Antihypertensive Agents; Arginine; Biomarkers; Brain; CADASIL; Chromatography, High Pressure Liquid; Endothelium, Vascular; Female; Humans; Hypertension; Lipids; Magnetic Resonance Imaging; Male; Middle Aged; Receptor, Notch3; Receptors, Notch; Risk Factors

2008
Plasma ADMA concentrations at birth and mechanical ventilation in preterm infants: a prospective pilot study.
    Pediatric pulmonology, 2008, Volume: 43, Issue:12

    Topics: Arginine; Female; Gestational Age; Humans; Infant, Newborn; Male; Nitric Oxide Synthase; Pilot Projects; Premature Birth; Prospective Studies; Respiration, Artificial; Respiratory Distress Syndrome, Newborn; Time Factors

2008
Plasma levels of asymmetric dimethylarginine in premature neonates: its possible involvement in developmental programming of chronic diseases.
    Acta paediatrica (Oslo, Norway : 1992), 2009, Volume: 98, Issue:3

    Topics: Arginine; Cardiovascular Diseases; Chronic Disease; Diabetes Mellitus, Type 2; Female; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Male; Metabolic Syndrome

2009
Carotid intima-media thickness in patients with cardiac syndrome X and its association with high circulating levels of asymmetric dimethylarginine.
    Atherosclerosis, 2009, Volume: 204, Issue:2

    Topics: Adult; Arginine; Carotid Artery Diseases; Carotid Artery, Common; Case-Control Studies; Female; Humans; Male; Microvascular Angina; Middle Aged; Nitrates; Nitrites; Tunica Intima; Tunica Media; Ultrasonography; Up-Regulation

2009
Involvement of asymmetric dimethylarginine (ADMA) in tubulointerstitial ischaemia in the early phase of diabetic nephropathy.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:4

    Topics: Adenoviridae; Amidohydrolases; Animals; Arginine; Diabetic Nephropathies; Disease Models, Animal; Genetic Vectors; Ischemia; Kidney; Male; Nephritis, Interstitial; Nitric Oxide; Rats; Rats, Sprague-Dawley

2009
HPLC analysis of asymmetric dimethylarginine (ADMA) and related arginine metabolites in human plasma using a novel non-endogenous internal standard.
    Clinica chimica acta; international journal of clinical chemistry, 2009, Volume: 401, Issue:1-2

    Topics: Arginine; Chromatography, High Pressure Liquid; Humans; Reference Standards; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction

2009
Asymmetric dimethylarginine predicts outcome and time of stay in hospital in patients attending an internal medicine emergency room.
    Clinica chimica acta; international journal of clinical chemistry, 2009, Volume: 401, Issue:1-2

    Topics: Adult; Aged; Arginine; Emergency Service, Hospital; Female; Humans; Length of Stay; Logistic Models; Male; Middle Aged; Prognosis; Proportional Hazards Models; Risk Assessment

2009
Asymmetric dimethylarginine in hematological malignancies: a preliminary study.
    Leukemia & lymphoma, 2008, Volume: 49, Issue:12

    Topics: Adult; Aged; Arginine; Biomarkers, Tumor; Case-Control Studies; Female; Hematologic Neoplasms; Humans; Male; Middle Aged; Prognosis; Risk Factors

2008
Evaluation of asymmetric dimethylarginine and homocysteine in microangiopathy-related cerebral damage.
    American journal of hypertension, 2009, Volume: 22, Issue:3

    Topics: Arginine; Arteriosclerosis; Biomarkers; Blood Pressure; Brain Damage, Chronic; Cerebral Infarction; Cerebrovascular Disorders; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Homocysteine; Humans; Hypertension; Japan; Magnetic Resonance Imaging; Male; Middle Aged; Nitric Oxide Synthase; Odds Ratio; Regression Analysis; Risk Assessment

2009
Role of symmetric dimethylarginine in vascular damage by increasing ROS via store-operated calcium influx in monocytes.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:5

    Topics: Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Arginine; Calcium; Calcium Channel Blockers; Calcium Channels; Captopril; Edetic Acid; Enzyme Inhibitors; Humans; Imidazoles; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Reactive Oxygen Species; Respiratory Burst; Thapsigargin; Vascular Diseases

2009
Advanced oxidative protein products are independently associated with endothelial function in peritoneal dialysis patients.
    Nephrology (Carlton, Vic.), 2009, Volume: 14, Issue:3

    Topics: Adult; Arginine; Cross-Sectional Studies; Endothelium, Vascular; Female; Glycation End Products, Advanced; Humans; Kidney Failure, Chronic; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress; Peritoneal Dialysis; Regression Analysis

2009
Transjugular intrahepatic portosystemic shunt-placement increases arginine/asymmetric dimethylarginine ratio in cirrhotic patients.
    World journal of gastroenterology, 2008, Dec-21, Volume: 14, Issue:47

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Female; Follow-Up Studies; Humans; Hypertension, Portal; Liver; Liver Cirrhosis; Male; Middle Aged; Nitric Oxide; Portasystemic Shunt, Transjugular Intrahepatic

2008
The beneficial effects of angiotensin-converting enzyme inhibitors on serum asymmetric dimethylarginine levels in the patients with cardiovascular disease.
    International journal of cardiology, 2010, Jun-25, Volume: 142, Issue:1

    Topics: Angiotensin-Converting Enzyme Inhibitors; Arginine; Biomarkers; Cardiovascular Diseases; Humans

2010
Asymmetric and symmetric dimethylarginines are of similar predictive value for cardiovascular risk in the general population.
    Atherosclerosis, 2009, Volume: 205, Issue:1

    Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Cohort Studies; Female; Humans; Male; Mass Spectrometry; Middle Aged; Nitric Oxide; Proportional Hazards Models; Prospective Studies; Risk

2009
Asymmetric dimethylarginine levels and carotid intima-media thickness in obese patients with polycystic ovary syndrome and their relationship to metabolic parameters.
    Fertility and sterility, 2010, Mar-01, Volume: 93, Issue:4

    Topics: Adolescent; Adult; Arginine; Energy Metabolism; Female; Humans; Obesity; Polycystic Ovary Syndrome; Prospective Studies; Tunica Intima; Tunica Media; Ultrasonography; Young Adult

2010
Plasma ADMA predicts restenosis of arteriovenous fistula.
    Journal of the American Society of Nephrology : JASN, 2009, Volume: 20, Issue:1

    Topics: Adult; Aged; Angioplasty, Balloon; Arginine; Arteriovenous Shunt, Surgical; C-Reactive Protein; Constriction, Pathologic; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multivariate Analysis; Renal Dialysis; Risk Factors

2009
Clinical implications of elevated asymmetric dimethylarginine in chronic kidney disease and end-stage renal disease.
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2009, Volume: 19, Issue:1

    Topics: Arginine; Cardiovascular Diseases; Carotid Arteries; Humans; Kidney Diseases; Kidney Failure, Chronic; Risk Factors; Uremia

2009
Asymmetric dimethylarginine is closely associated with the development and progression of nephropathy in patients with type 2 diabetes.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:6

    Topics: Adult; Aged; Albuminuria; Arginine; Biomarkers; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Humans; Japan; Male; Middle Aged; Nitric Oxide Synthase; Prognosis; Proportional Hazards Models; Prospective Studies

2009
Acute effects of Helicobacter pylori extracts on gastric mucosal blood flow in the mouse.
    World journal of gastroenterology, 2009, Jan-14, Volume: 15, Issue:2

    Topics: Animals; Arginine; Blood Flow Velocity; Gastric Mucosa; Helicobacter pylori; Lidocaine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type II; Signal Transduction; Water

2009
Circulating asymmetric dimethylarginine, endothelin-1 and cell adhesion molecules in women with gestational diabetes.
    Acta diabetologica, 2009, Volume: 46, Issue:4

    Topics: Adult; Arginine; Blood Glucose; Case-Control Studies; Diabetes, Gestational; Endothelin-1; Female; Humans; Pregnancy; Vascular Cell Adhesion Molecule-1

2009
Endothelial and red blood cell turnover rate--factors possibly affecting circulating ADMA levels?
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:4

    Topics: Amidohydrolases; Arginine; Endothelial Cells; Erythrocytes; Erythropoietin; Humans

2009
[The effect of plasma asymmetric dimethylarginine (ADMA) level and L-arginine/ADMA ratio on the development of coronary collaterals].
    Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2008, Volume: 36, Issue:6

    Topics: Arginine; Collateral Circulation; Coronary Stenosis; Humans; Nitric Oxide Synthase

2008
Losartan inhibits monocytic adhesion induced by ADMA via downregulation of chemokine receptors in monocytes.
    European journal of clinical pharmacology, 2009, Volume: 65, Issue:5

    Topics: Arginine; Cell Adhesion; Cells, Cultured; Chemokine CCL2; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Humans; Interleukin-8; Losartan; Monocytes; NF-kappa B; Receptors, Chemokine; RNA, Messenger; Time Factors

2009
Asymmetric dimethylarginine induces tissue factor expression in monocytes via NF-kappaB-dependent pathway: Role in acute coronary syndromes.
    Atherosclerosis, 2009, Volume: 205, Issue:2

    Topics: Acute Coronary Syndrome; Aged; Angina Pectoris; Arginine; Blood Coagulation; Case-Control Studies; Coagulants; Female; Humans; Male; Middle Aged; Monocytes; NF-kappa B; Nitric Oxide Synthase; Thromboplastin

2009
De novo synthesis of trideuteromethyl esters of amino acids for use in GC-MS and GC-tandem MS exemplified for ADMA in human plasma and urine: standardization, validation, comparison and proof of evidence for their aptitude as internal standards.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Aug-01, Volume: 877, Issue:23

    Topics: Arginine; Gas Chromatography-Mass Spectrometry; Humans; Reference Standards; Tandem Mass Spectrometry

2009
ADMA and SDMA levels in healthy men exposed to tobacco smoke.
    Atherosclerosis, 2009, Volume: 205, Issue:2

    Topics: Adolescent; Adult; Arginine; Cerebrovascular Disorders; Coronary Vessels; Humans; Male; Middle Aged; Nitric Oxide Synthase; Regression Analysis; Risk Factors; Smoking; Tobacco Smoke Pollution

2009
Asymmetrical dimethylarginine triggers lipolysis and inflammatory response via induction of endoplasmic reticulum stress in cultured adipocytes.
    American journal of physiology. Endocrinology and metabolism, 2009, Volume: 296, Issue:4

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Arginine; Carrier Proteins; Cells, Cultured; Endoplasmic Reticulum; Inflammation; Lipolysis; Mice; Muscle Fibers, Skeletal; NF-kappa B; Perilipin-1; Phosphoproteins; Protein Processing, Post-Translational; Stress, Physiological; Up-Regulation

2009
ADMA and the brain: an unfolding story.
    American journal of hypertension, 2009, Volume: 22, Issue:3

    Topics: Animals; Arginine; Brain Chemistry; Cattle; Cerebrovascular Circulation; Cerebrovascular Disorders; Cross-Sectional Studies; Glomerular Filtration Rate; Homocysteine; Magnetic Resonance Imaging; Nitric Oxide Synthase

2009
Relationship of baseline plasma ADMA levels to cardiovascular outcomes at 2 years in men with acute coronary syndrome referred for coronary angiography.
    Coronary artery disease, 2009, Volume: 20, Issue:2

    Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Arginine; Biomarkers; Coronary Angiography; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Time Factors; Up-Regulation

2009
Telmisartan decreases plasma levels of asymmetrical dimethyl-L-arginine and improves lipid and glucose metabolism and vascular function.
    International heart journal, 2009, Volume: 50, Issue:1

    Topics: Administration, Oral; Aged; Angiotensin II Type 1 Receptor Blockers; Arginine; Benzimidazoles; Benzoates; Blood Glucose; Blood Pressure; Cholesterol, LDL; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Humans; Hypertension; Male; Nitric Oxide Synthase Type III; PPAR gamma; Telmisartan; Treatment Outcome

2009
Maternal serum ADMA is not associated with proinflammatory cytokines or C-reactive protein during normal pregnancy.
    Cytokine, 2009, Volume: 46, Issue:2

    Topics: Adult; Arginine; Biomarkers; C-Reactive Protein; Creatinine; Cytokines; Enzyme Inhibitors; Female; Gestational Age; Humans; Interleukin-6; Lipids; Pregnancy; Tumor Necrosis Factor-alpha

2009
Determinants of platelet activation in hypertensives with microalbuminuria.
    Free radical biology & medicine, 2009, Apr-01, Volume: 46, Issue:7

    Topics: Aged; Albuminuria; Arginine; Biomarkers; Disease Progression; Endothelium; Female; Humans; Hypertension; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Male; Middle Aged; Nitric Oxide; Oxidative Stress; P-Selectin; Platelet Activation; Prostaglandins A; Thromboxane B2; Vitamin E

2009
Asymmetric dimethylarginine and nitric oxide levels in migraine during the interictal period.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2009, Volume: 16, Issue:5

    Topics: Adult; Arginine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Migraine Disorders; Nitrates; Nitric Oxide; Nitrites; Statistics, Nonparametric

2009
Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community.
    Circulation, 2009, Mar-31, Volume: 119, Issue:12

    Topics: Aged; Arginine; Cardiovascular Diseases; Cause of Death; Diabetes Mellitus; Follow-Up Studies; Humans; Incidence; Middle Aged; Mortality; Predictive Value of Tests; Prognosis; Proportional Hazards Models

2009
Dimethylarginine levels in cerebrospinal fluid of hyperacute ischemic stroke patients are associated with stroke severity.
    Neurochemical research, 2009, Volume: 34, Issue:9

    Topics: Aged; Arginine; Brain Ischemia; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Stroke

2009
Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis.
    European heart journal, 2009, Volume: 30, Issue:9

    Topics: Aged; Arginine; Atherosclerosis; Coronary Artery Bypass; Coronary Artery Disease; Endothelium, Vascular; Female; Humans; Male; Nitric Oxide Synthase Type III; Oxidative Stress; Saphenous Vein; Superoxides; Vasodilation

2009
ADMA injures the glomerular filtration barrier: role of nitric oxide and superoxide.
    American journal of physiology. Renal physiology, 2009, Volume: 296, Issue:6

    Topics: Albumins; Animals; Anthracenes; Arginine; Free Radical Scavengers; Glomerular Basement Membrane; Guanylate Cyclase; Male; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidation-Reduction; Permeability; Propane; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Superoxides

2009
Differential effects of cross-sex hormonal treatment on plasma asymmetric dimethylarginine (ADMA) in healthy male-to-female and female-to-male transsexuals.
    Atherosclerosis, 2009, Volume: 206, Issue:1

    Topics: Adult; Amino Acids; Androgen Antagonists; Arginine; Cyproterone Acetate; Estradiol; Estrogens; Ethinyl Estradiol; Female; Gonadal Steroid Hormones; Humans; Male; Testosterone; Transsexualism

2009
Correlation of biomarkers of endothelium dysfunction and matrix remodeling in patients with systemic sclerosis.
    The Journal of rheumatology, 2009, Volume: 36, Issue:5

    Topics: Arginine; Biomarkers; Endothelium, Vascular; Enzyme Inhibitors; Extracellular Matrix; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Raynaud Disease; Regional Blood Flow; Scleroderma, Systemic; Skin; Tissue Inhibitor of Metalloproteinase-1

2009
Relationship between cerebral arterial pulsatility and carotid intima media thickness in diabetic and non-diabetic patients with non-alcoholic fatty liver disease.
    Journal of endocrinological investigation, 2009, Volume: 32, Issue:1

    Topics: Aged; Arginine; Basilar Artery; Carotid Arteries; Diabetes Mellitus, Type 2; Fatty Liver; Female; Humans; Male; Middle Aged; Pulsatile Flow; Tunica Intima; Tunica Media; Ultrasonography

2009
Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death.
    British journal of haematology, 2009, Volume: 145, Issue:4

    Topics: Anemia, Sickle Cell; Arginine; Case-Control Studies; Citrulline; Follow-Up Studies; Hemolysis; Humans; Hypertension, Pulmonary; Kidney Diseases; Linear Models; Nitric Oxide Synthase; omega-N-Methylarginine; Oxygen; Proportional Hazards Models; Risk; Survival Rate

2009
Involvement of asymmetric dimethylarginine (ADMA) in glomerular capillary loss and sclerosis in a rat model of chronic kidney disease (CKD).
    Life sciences, 2009, Jun-05, Volume: 84, Issue:23-24

    Topics: Amidohydrolases; Animals; Arginine; Capillaries; Disease Models, Animal; Glomerulosclerosis, Focal Segmental; Humans; Kidney Failure, Chronic; Kidney Glomerulus; Rats

2009
Elevation of serum apelin-13 is positively correlated with ADMA in patients on maintenance hemodialysis.
    Clinical nephrology, 2009, Volume: 71, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Female; Humans; Intercellular Signaling Peptides and Proteins; Kidney Failure, Chronic; Male; Middle Aged; Nitrates; Nitrites; Renal Dialysis; Time Factors

2009
HDL-cholesterol, blood pressure, and asymmetric dimethylarginine are significantly associated with arterial wall thickness in children.
    Arteriosclerosis, thrombosis, and vascular biology, 2009, Volume: 29, Issue:6

    Topics: Arginine; Biomarkers; Blood Pressure; Cardiovascular Diseases; Carotid Arteries; Carotid Artery Diseases; Child; Cholesterol, HDL; Cross-Sectional Studies; Disease Progression; Female; Humans; Male; New South Wales; Risk Factors; Tunica Intima; Tunica Media; Ultrasonography

2009
Stent placement in patients with coronary heart disease decreases plasma levels of the endogenous nitric oxide synthase inhibitor ADMA.
    International journal of molecular medicine, 2009, Volume: 23, Issue:5

    Topics: Aged; Arginine; Cardiovascular Surgical Procedures; Case-Control Studies; Coronary Disease; Down-Regulation; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitric Oxide Synthase; Stents; Time Factors

2009
Vascular biomarkers in the metabolic syndrome.
    Expert review of molecular diagnostics, 2009, Volume: 9, Issue:3

    Topics: Arginine; Biomarkers; Blood Vessels; Endothelium, Vascular; Enzyme Inhibitors; Glycation End Products, Advanced; Humans; Insulin Resistance; Metabolic Syndrome; Signal Transduction; Stem Cells

2009
Low arginine/asymmetric dimethylarginine ratio deteriorates systemic hemodynamics and organ blood flow in a rat model.
    Critical care medicine, 2009, Volume: 37, Issue:6

    Topics: Animals; Arginine; Hemodynamics; Male; Rats; Rats, Wistar; Regional Blood Flow

2009
Asymmetric dimethylarginine and mortality in stages 3 to 4 chronic kidney disease.
    Clinical journal of the American Society of Nephrology : CJASN, 2009, Volume: 4, Issue:6

    Topics: Adult; Arginine; Cohort Studies; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multivariate Analysis; Nitric Oxide; Prevalence; Proportional Hazards Models; Randomized Controlled Trials as Topic; Renal Insufficiency, Chronic; Risk Factors; Severity of Illness Index

2009
Ezetimibe decreases serum levels of asymmetric dimethylarginine (ADMA) and ameliorates renal injury in non-diabetic chronic kidney disease patients in a cholesterol-independent manner.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Adult; Arginine; Azetidines; Cholesterol; Dyslipidemias; Ezetimibe; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged

2009
Serum asymmetric dimethylarginine and endothelial function after renal transplantation.
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2009, Volume: 34, Issue:4

    Topics: Adult; Arginine; Case-Control Studies; Endothelium, Vascular; Female; Humans; Kidney Transplantation; Male; Middle Aged; Postoperative Period; Uremia

2009
Circulating levels of advanced glycation end products (AGE) and interleukin-6 (IL-6) are independent determinants of serum asymmetric dimethylarginine (ADMA) levels in patients with septic shock.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Aged; Arginine; Biomarkers; Female; Glycation End Products, Advanced; Humans; Interleukin-6; Male; Middle Aged; Shock, Septic

2009
Role of anandamide transporter in regulating calcitonin gene-related peptide production and blood pressure in hypertension.
    Journal of hypertension, 2009, Volume: 27, Issue:6

    Topics: Animals; Arachidonic Acids; Arginine; Base Sequence; Blood Pressure; Calcitonin Gene-Related Peptide; Carrier Proteins; Case-Control Studies; DNA Primers; Endocannabinoids; Ganglia, Spinal; Humans; Hypertension; Hypertension, Renovascular; In Vitro Techniques; Lymphocytes; Male; Polyunsaturated Alkamides; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; RNA, Messenger

2009
Non-invasive assessment of coronary flow reserve and ADMA levels: a case-control study of early rheumatoid arthritis patients.
    Rheumatology (Oxford, England), 2009, Volume: 48, Issue:7

    Topics: Adult; Aged; Arginine; Arthritis, Rheumatoid; Biomarkers; Carotid Artery, Common; Case-Control Studies; Coronary Circulation; Dipyridamole; Echocardiography, Stress; Female; Humans; Linear Models; Male; Microcirculation; Middle Aged; Nitric Oxide Synthase; Regional Blood Flow; Tunica Media; Vasodilator Agents

2009
Inhibition of natriuretic factors increases blood pressure in rats.
    American journal of physiology. Renal physiology, 2009, Volume: 297, Issue:2

    Topics: Amidohydrolases; Animals; Antioxidants; Arginine; Blood Pressure; Buthionine Sulfoximine; Cyclic N-Oxides; Disease Models, Animal; Dopamine; Hypertension; Kidney Tubules, Proximal; Male; Natriuresis; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidants; Oxidative Stress; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Serine; Signal Transduction; Sodium Chloride, Dietary; Sodium-Potassium-Exchanging ATPase; Spin Labels

2009
A study of endothelial function and circulating asymmetric dimethylarginine levels in people with Type 1 diabetes without macrovascular disease or microalbuminuria.
    Cardiovascular diabetology, 2009, Jun-01, Volume: 8

    Topics: Adolescent; Adult; Albuminuria; Arginine; Biomarkers; Brachial Artery; Case-Control Studies; Cell Adhesion Molecules; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Endothelium, Vascular; Female; Humans; Male; Nitric Oxide Synthase Type III; Risk Factors; Ultrasonography; Vasodilation; Young Adult

2009
Methylarginines and mortality in patients with end stage renal disease: a prospective cohort study.
    Atherosclerosis, 2009, Volume: 207, Issue:2

    Topics: Adult; Aged; Arginine; Biomarkers; Female; Hemoglobins; Humans; Kaplan-Meier Estimate; Kidney Failure, Chronic; Male; Methylation; Middle Aged; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Renal Dialysis; Risk Assessment; Risk Factors

2009
Postmenopausal women with osteoporosis may be associated with high endothelin-1.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2009, Volume: 25, Issue:10

    Topics: Arginine; Bone Density; Chi-Square Distribution; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Female; Humans; Middle Aged; Osteoporosis, Postmenopausal; Regression Analysis

2009
Asymmetric dimethylarginine reference intervals determined with liquid chromatography-tandem mass spectrometry: results from the Framingham offspring cohort.
    Clinical chemistry, 2009, Volume: 55, Issue:8

    Topics: Age Factors; Aged; Arginine; Cardiovascular Diseases; Chromatography, Liquid; Cohort Studies; Female; Homocysteine; Humans; Male; Middle Aged; Multivariate Analysis; Reference Standards; Sensitivity and Specificity; Sex Factors; Tandem Mass Spectrometry

2009
Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: potential mechanisms beyond nitric oxide synthase inhibition.
    Arteriosclerosis, thrombosis, and vascular biology, 2009, Volume: 29, Issue:9

    Topics: Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Citrulline; Coronary Artery Disease; Creatinine; Female; Humans; Lysine; Male; Metabolomics; Methylation; Middle Aged; Nitric Oxide Synthase; Odds Ratio; omega-N-Methylarginine; Ornithine; Prognosis; Prospective Studies; Protein Processing, Post-Translational; Risk Assessment; Risk Factors; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Time Factors

2009
Paradoxical effect of L-arginine: acceleration of endothelial cell senescence.
    Biochemical and biophysical research communications, 2009, Sep-04, Volume: 386, Issue:4

    Topics: Arginase; Arginine; Cationic Amino Acid Transporter 1; Cationic Amino Acid Transporter 2; Cells, Cultured; Cellular Senescence; Endothelial Cells; Endothelium, Vascular; Humans; Nitric Oxide; Oxidative Stress

2009
Correlates of arterial stiffness in an ageing population: role of asymmetric dimethylarginine.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Aged; Aging; Arginine; Endothelium, Vascular; Female; Humans; Hypertension; Male; Middle Aged; Risk Factors; Vascular Resistance

2009
Renal resistance index in renal allograft recipients: a role for ADMA.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2009, Volume: 54, Issue:2

    Topics: Adult; Aged; Arginine; Female; Humans; Kidney Transplantation; Male; Middle Aged; Renal Artery; Vascular Resistance; Young Adult

2009
[Relationship between changes of endogenous nitric oxide synthase inhibitor and hydrolase and initiation of pre-eclampsia].
    Zhonghua fu chan ke za zhi, 2009, Volume: 44, Issue:4

    Topics: Adult; Amidohydrolases; Arginine; Chromatography, High Pressure Liquid; Female; Humans; Nitric Oxide; Nitric Oxide Synthase; Placenta; Polymerase Chain Reaction; Pre-Eclampsia; Pregnancy; RNA, Messenger

2009
Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), arginine, and 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha) level in patients with inflammatory bowel diseases.
    Inflammatory bowel diseases, 2010, Volume: 16, Issue:1

    Topics: Adolescent; Adult; Aged; Arginine; Biomarkers; Case-Control Studies; Colitis, Ulcerative; Crohn Disease; Dinoprost; Female; Humans; Male; Middle Aged; Oxidative Stress; Young Adult

2010
Asymmetric dimethylarginine in the maternal and fetal circulation in preeclampsia.
    Pediatric research, 2009, Volume: 66, Issue:4

    Topics: Adult; Arginine; Female; Fetus; Humans; Infant, Newborn; Maternal-Fetal Exchange; Nitric Oxide; Pre-Eclampsia; Pregnancy; Young Adult

2009
Asymmetric dimethylarginine impairs glucose utilization via ROS/TLR4 pathway in adipocytes: an effect prevented by vitamin E.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2009, Volume: 24, Issue:1-2

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Arginine; Cell Line; Enzyme Inhibitors; Glucose; Glucose Transporter Type 4; Insulin Receptor Substrate Proteins; Mice; Nitric Oxide; Nitric Oxide Synthase; Reactive Oxygen Species; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Vitamin E

2009
Positive association of serum levels of advanced glycation end products and high mobility group box-1 with asymmetric dimethylarginine in nondiabetic chronic kidney disease patients.
    Metabolism: clinical and experimental, 2009, Volume: 58, Issue:11

    Topics: Adult; Arginine; Cross-Sectional Studies; Dyslipidemias; Female; Glycation End Products, Advanced; Hemodynamics; HMGB1 Protein; Humans; Kidney Failure, Chronic; Male; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Regression Analysis

2009
Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginine.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 331, Issue:1

    Topics: Amidohydrolases; Animals; Arginine; Cationic Amino Acid Transporter 1; Cell Line; Cells, Cultured; Haplorhini; Humans; Isoxazoles; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase; Receptors, Cytoplasmic and Nuclear

2009
Proteomic identification of cytosolic proteins that undergo arginine methylation during rat liver regeneration.
    Electrophoresis, 2009, Volume: 30, Issue:14

    Topics: Amino Acid Sequence; Animals; Arginine; Cytosol; Electrophoresis, Gel, Two-Dimensional; Liver Regeneration; Mass Spectrometry; Methylation; Molecular Sequence Data; Protein-Arginine N-Methyltransferases; Proteins; Proteomics; Rats; Rats, Sprague-Dawley

2009
Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study.
    Stroke, 2009, Volume: 40, Issue:9

    Topics: Adult; Aged; Arginine; Atherosclerosis; Biomarkers; Brain; Brain Infarction; Cohort Studies; Endothelium, Vascular; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nitric Oxide Synthase Type III; Radiography; Risk Factors

2009
The conjoint detrimental effect of chronic periodontal disease and systemic inflammation on asymmetric dimethyl-arginine in untreated hypertensive subjects.
    Atherosclerosis, 2010, Volume: 208, Issue:1

    Topics: Arginine; Chronic Disease; Cross-Sectional Studies; Female; Humans; Hypertension; Inflammation; Male; Middle Aged; Periodontal Diseases

2010
Altered asymmetric dimethyl arginine metabolism in allergically inflamed mouse lungs.
    American journal of respiratory cell and molecular biology, 2010, Volume: 42, Issue:1

    Topics: Amidohydrolases; Animals; Arginine; Asthma; Collagen; Cytosol; Inflammation; Lung; Male; Mice; Mice, Inbred BALB C; Mitochondria; Nitric Oxide Synthase; Peroxynitrous Acid; Protein-Arginine N-Methyltransferases

2010
Plasma concentrations of the cardiovascular risk factor asymmetric dimethylarginine (ADMA) are increased in patients with HIV-1 infection and correlate with immune activation markers.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Cohort Studies; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Risk Factors; Th1 Cells; Young Adult

2009
Quantification of arginine and its mono- and dimethylated analogs NMMA, ADMA and SDMA in biological fluids by LC-MS/MS: Is LC superfluous?
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Oct-01, Volume: 877, Issue:27

    Topics: Arginine; Chromatography, Liquid; Humans; Reproducibility of Results; Tandem Mass Spectrometry

2009
Nested case-control study of one-carbon metabolites in mid-pregnancy and risks of cleft lip with and without cleft palate.
    Pediatric research, 2009, Volume: 66, Issue:5

    Topics: Adult; Arginine; Carbon; Case-Control Studies; Cleft Lip; Cleft Palate; Dietary Supplements; Female; Folic Acid; Humans; Maternal Age; Nutritional Sciences; Odds Ratio; Pregnancy; Vitamins

2009
Increased nitric oxide stress is associated with migraine.
    Cephalalgia : an international journal of headache, 2010, Volume: 30, Issue:4

    Topics: Adult; Aged; Amidohydrolases; Arginine; Female; Humans; Male; Migraine with Aura; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Polymorphism, Genetic; Risk Factors; Stress, Physiological

2010
Determinants of occurrence of aortic sclerosis in an aging population.
    JACC. Cardiovascular imaging, 2009, Volume: 2, Issue:8

    Topics: Age Factors; Aged; Aorta; Aortic Valve; Aortic Valve Stenosis; Arginine; Biomarkers; Blood Platelets; Body Mass Index; Calcinosis; Cardiovascular Diseases; Cross-Sectional Studies; Disease Progression; Echocardiography, Doppler; Elasticity; Endothelium, Vascular; Female; Heart Valve Diseases; Humans; Linear Models; Male; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Platelet Aggregation; Prospective Studies; Pulsatile Flow; Risk Assessment; Risk Factors; Sclerosis

2009
Collagen synthesis, nitric oxide and asymmetric dimethylarginine in diabetic subjects undergoing hyperbaric oxygen therapy.
    Physiological research, 2010, Volume: 59, Issue:3

    Topics: Aged; Arginine; Biomarkers; Collagen; Diabetic Foot; Female; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Nitric Oxide; Peptide Fragments; Procollagen; Time Factors; Treatment Outcome; Wound Healing

2010
Increased levels of asymmetric dimethylarginine (ADMA) in patients with ankylosing spondylitis.
    Internal medicine (Tokyo, Japan), 2009, Volume: 48, Issue:16

    Topics: Adult; Arginine; Biomarkers; Endothelin-1; Female; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Risk Factors; Spondylitis, Ankylosing; Up-Regulation

2009
Effect of keto acids on asymmetric dimethylarginine, muscle, and fat tissue in chronic kidney disease and after kidney transplantation.
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2009, Volume: 19, Issue:5 Suppl

    Topics: Adipose Tissue; Adult; Aged; Amino Acids; Arginine; Body Mass Index; Diet, Protein-Restricted; Humans; Keto Acids; Kidney Failure, Chronic; Kidney Transplantation; Middle Aged; Muscles; Obesity; Randomized Controlled Trials as Topic; Serum Albumin

2009
Is asymmetric dimethylarginine responsible for the vascular events in patients under antiepileptic drug treatment?
    Epilepsy research, 2009, Volume: 87, Issue:1

    Topics: Adult; Anticonvulsants; Arginine; Arterial Occlusive Diseases; Carbamazepine; Drug Monitoring; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Statistics, Nonparametric; Valproic Acid; Vitamin B 12

2009
Asymmetric dimethylarginine endogenous inhibition of nitric oxide synthase causes differential vasculature effects.
    Medical science monitor : international medical journal of experimental and clinical research, 2009, Volume: 15, Issue:9

    Topics: Animals; Arginine; Arteries; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Humans; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Tissue Culture Techniques

2009
Synergistic effects of asymmetrical dimethyl-L-arginine accumulation and endothelial progenitor cell deficiency on renal function decline during a 2-year follow-up in stable angina.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Volume: 25, Issue:8

    Topics: Adult; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antigens, CD34; Arginine; Biomarkers; Cell Count; Endothelial Cells; Follow-Up Studies; Glomerular Filtration Rate; Humans; Kidney; Leukocytes; Male; Middle Aged; Multivariate Analysis; Stem Cells

2010
PRMT-1 and DDAHs-induced ADMA upregulation is involved in ROS- and RAS-mediated diabetic retinopathy.
    Experimental eye research, 2009, Volume: 89, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Cells, Cultured; Cyclic GMP; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelial Cells; Male; Protein-Arginine N-Methyltransferases; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Renin-Angiotensin System; Up-Regulation

2009
Role of neutrophils in arginine-asymmetric dimethylarginine pathway subsequent to endotoxemia.
    Annals of the New York Academy of Sciences, 2009, Volume: 1173 Suppl 1

    Topics: Animals; Arginine; Disease Models, Animal; Endotoxemia; Guinea Pigs; Lipopolysaccharides; Liver; Male; Neutrophils; Peroxidase; Tyrosine

2009
Altered metabolisms of mediators controlling vascular function and enhanced oxidative stress in asymptomatic children with congenital portosystemic venous shunt.
    Metabolism: clinical and experimental, 2010, Volume: 59, Issue:1

    Topics: Amino Acids; Ammonia; Arginine; Blood Vessels; Child, Preschool; Endothelin-1; Female; Humans; Infant; Male; Nitric Oxide; Oxidative Stress; Portal System

2010
Ex vivo gene transferring of human dimethylarginine dimethylaminohydrolase-2 improved endothelial dysfunction in diabetic rat aortas and high glucose-treated endothelial cells.
    Atherosclerosis, 2010, Volume: 209, Issue:1

    Topics: Amidohydrolases; Animals; Aorta; Arginine; Diabetes Mellitus; Diabetes Mellitus, Experimental; Endothelium, Vascular; Gene Transfer Techniques; Glucose; Humans; Hyperglycemia; Male; Rats; Rats, Sprague-Dawley

2010
[Effects of Xuefu Zhuyu decoction on serum asymmetric dimethylarginine in atherosclerosis rabbits].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009, Volume: 34, Issue:12

    Topics: Animals; Arginine; Atherosclerosis; Cholesterol; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Male; Rabbits; Random Allocation; Triglycerides

2009
The ADMA/DDAH pathway regulates VEGF-mediated angiogenesis.
    Arteriosclerosis, thrombosis, and vascular biology, 2009, Volume: 29, Issue:12

    Topics: Amidohydrolases; Animals; Apoptosis; Arginine; Cell Adhesion Molecules; Cell Polarity; Cell Proliferation; Cells, Cultured; Chemotaxis; Endothelial Cells; Focal Adhesions; Humans; In Vitro Techniques; Mice; Mice, Knockout; Microfilament Proteins; Neovascularization, Physiologic; Neuropeptides; Nitric Oxide; Phosphoproteins; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Signal Transduction; Vascular Endothelial Growth Factor A

2009
Association of homocysteine, asymmetric dimethylarginine, and nitric oxide with preeclampsia.
    Archives of gynecology and obstetrics, 2010, Volume: 282, Issue:4

    Topics: Arginine; Biomarkers; Case-Control Studies; Chromatography, Liquid; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Nitric Oxide; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Third; Tandem Mass Spectrometry

2010
Dimethylarginine dimethylaminohydrolase-1 transgenic mice are not protected from ischemic stroke.
    PloS one, 2009, Oct-07, Volume: 4, Issue:10

    Topics: Amidohydrolases; Animals; Arginine; Brain; Endothelium, Vascular; Genotype; Infarction, Middle Cerebral Artery; Ischemia; Male; Mice; Mice, Transgenic; Models, Biological; Nitric Oxide; Stroke

2009
Role of asymmetric-dimethyl-L-arginine (ADMA) and nitrite/nitrate (NOx) in the pathogenesis of oxidative stress in female subjects with uncomplicated type 1 diabetes mellitus.
    Diabetes research and clinical practice, 2009, Volume: 86, Issue:3

    Topics: Adult; Arginine; Blood Glucose; Blood Specimen Collection; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 1; Feeding Behavior; Female; Glycated Hemoglobin; Humans; Nitrates; Nitrites; Oxidative Stress; Reference Values; Uric Acid

2009
Asymmetrical dimethylarginine is associated with renal and cardiovascular outcomes and all-cause mortality in renal transplant recipients.
    Kidney international, 2010, Volume: 77, Issue:1

    Topics: Adult; Arginine; Cardiovascular Diseases; Graft Rejection; Humans; Kidney Diseases; Kidney Transplantation; Middle Aged; Randomized Controlled Trials as Topic; Survival Rate; Treatment Outcome

2010
Asymmetric dimethylarginine: understanding the physiology, genetics, and clinical relevance of this novel biomarker. Proceedings of the 4th International Symposium on ADMA.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Arginine; Austria; Biomarkers; Cardiovascular Diseases; Humans; Internationality; Nitric Oxide

2009
Distribution of asymmetric dimethylarginine among 980 healthy, older adults of different ethnicities.
    Clinical chemistry, 2010, Volume: 56, Issue:1

    Topics: Aged; Arginine; Asian People; Black People; Cardiovascular Diseases; Cystatin C; Enzyme-Linked Immunosorbent Assay; Female; Glomerular Filtration Rate; Hispanic or Latino; Humans; Male; Middle Aged; Regression Analysis; Risk Factors; White People

2010
Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:1

    Topics: Amidohydrolases; Arginine; Blotting, Western; Cells, Cultured; Chromatin; Chromatography, High Pressure Liquid; DNA Primers; Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoprecipitation; Lentivirus; Nitrites; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2; Transfection

2010
Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1-deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine.
    Circulation, 2009, Dec-01, Volume: 120, Issue:22

    Topics: Acetylcholine; Amidohydrolases; Animals; Aorta; Arginine; Brain; Cholinergic Agents; Endothelium, Vascular; Female; Hypertension; Kidney; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Nitric Oxide; Vasodilation; Ventricular Function, Left

2009
A click chemistry mediated in vivo activity probe for dimethylarginine dimethylaminohydrolase.
    Journal of the American Chemical Society, 2009, Oct-28, Volume: 131, Issue:42

    Topics: Amidohydrolases; Arginine; Cell Line; Humans; Molecular Structure; Substrate Specificity

2009
ADMA concentration changes across the menstrual cycle and during oral contraceptive use: the Cardiovascular Risk in Young Finns Study.
    European journal of endocrinology, 2010, Volume: 162, Issue:2

    Topics: Adult; Arginine; Atherosclerosis; Brachial Artery; C-Reactive Protein; Contraceptives, Oral; Creatinine; Estrogens; Female; Finland; Humans; Menstrual Cycle; Progesterone Congeners; Prospective Studies; Risk Factors; Vasodilation; Young Adult

2010
Asymmetric dimethylarginine damages connexin43-mediated endothelial gap junction intercellular communication.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 2009, Volume: 87, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Cell Communication; Cells, Cultured; Connexin 43; Endothelial Cells; Enzyme Inhibitors; Fluorescence Recovery After Photobleaching; Gap Junctions; Humans; Lysophosphatidylcholines; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Signal Transduction

2009
Serum ADMA concentration-- an independent factor determining FMD impairment in cardiac syndrome X.
    Upsala journal of medical sciences, 2009, Volume: 114, Issue:4

    Topics: Aged; Arginine; Biomarkers; Carotid Arteries; Case-Control Studies; Endothelium, Vascular; Female; Humans; Male; Microvascular Angina; Middle Aged; Nitric Oxide; Nitroglycerin; Tunica Intima; Ultrasonography; Vasodilation

2009
Dimethylarginines: their vascular and metabolic roles in Africans and Caucasians.
    European journal of endocrinology, 2010, Volume: 162, Issue:3

    Topics: Adult; Age Factors; Aged; Arginine; Black People; Blood Flow Velocity; Blood Glucose; Blood Pressure; Blood Vessels; Cross-Sectional Studies; Female; Humans; Insulin; Insulin Resistance; Male; Middle Aged; Patient Selection; Pulsatile Flow; Regression Analysis; Sex Factors; South Africa; Vascular Resistance; White People

2010
Increased serum asymmetric dimethylarginine levels in primary dysmenorrhea.
    Gynecologic and obstetric investigation, 2010, Volume: 69, Issue:3

    Topics: Adolescent; Adult; Arginine; Biomarkers; Body Mass Index; C-Reactive Protein; Cholesterol, LDL; Cohort Studies; Dysmenorrhea; Endothelium, Vascular; Female; Humans; Ischemia; Nitric Oxide; Pelvic Pain; Sensitivity and Specificity; Triglycerides; Uterus; Young Adult

2010
Association between plasma asymmetrical dimethylarginine activity and saphenous vein graft disease in patients with coronary bypass.
    Coronary artery disease, 2010, Volume: 21, Issue:1

    Topics: Aged; Arginine; Biomarkers; Coronary Angiography; Coronary Artery Bypass; Enzyme-Linked Immunosorbent Assay; Female; Graft Occlusion, Vascular; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Platelet Count; Predictive Value of Tests; Risk Assessment; Risk Factors; Saphenous Vein; Up-Regulation; Vascular Patency

2010
Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphisms.
    Kidney international, 2010, Volume: 77, Issue:5

    Topics: Alleles; Amidohydrolases; Arginine; Case-Control Studies; Cohort Studies; Cross-Sectional Studies; Enzyme Inhibitors; Female; Gene Frequency; Genetic Variation; Genotype; Glomerular Filtration Rate; Humans; Kidney Failure, Chronic; Longitudinal Studies; Male; Polymorphism, Genetic; RNA, Messenger

2010
Growth differentiation factor 15 and coronary collateral formation.
    Clinical cardiology, 2010, Volume: 33, Issue:1

    Topics: Aged; Analysis of Variance; Arginine; Collateral Circulation; Coronary Angiography; Coronary Artery Disease; Coronary Circulation; Coronary Stenosis; Cross-Sectional Studies; Female; Growth Differentiation Factor 15; Humans; Male; Middle Aged; Prognosis; Statistics, Nonparametric; Vascular Endothelial Growth Factor Receptor-1

2010
Asymmetric dimethylarginine in angiotensin II-induced hypertension.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2010, Volume: 298, Issue:3

    Topics: Amidohydrolases; Angiotensin II; Animals; Arginine; Blood Pressure; Fibrosis; Hypertension, Renal; Kidney Cortex; Male; NADPH Oxidases; Nitrates; Nitrites; Oxidative Stress; Protein-Arginine N-Methyltransferases; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Vasoconstrictor Agents

2010
Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production.
    The Journal of biological chemistry, 2010, Feb-19, Volume: 285, Issue:8

    Topics: Adenoviridae; Animals; Arginine; Atherosclerosis; Chlorocebus aethiops; Citrulline; COS Cells; Diabetes Mellitus; Endothelial Cells; Gene Expression; Heart Failure; Humans; Hydrolysis; Hypertension; Kidney; Liver; Mice; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Transaminases; Transduction, Genetic

2010
Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia.
    Circulation research, 2010, Feb-19, Volume: 106, Issue:3

    Topics: Acetylcholine; Amidohydrolases; Animals; Arginine; Arterioles; Carotid Artery Thrombosis; Cerebral Arterial Diseases; Diet; Folic Acid Deficiency; Humans; Hyperhomocysteinemia; Hypertrophy; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Papaverine; Vasodilation; Vasodilator Agents

2010
Ethylene glycol induced hyperoxaluria increases plasma and renal tissue asymmetrical dimethylarginine in rats: a new pathogenetic link in hyperoxaluria induced disorders.
    The Journal of urology, 2010, Volume: 183, Issue:2

    Topics: Animals; Arginine; Ethylene Glycol; Hyperoxaluria; Rats; Rats, Sprague-Dawley; Tissue Distribution; Verapamil

2010
Asymmetric dimethylarginine (ADMA) is present in plasma proteins of healthy subjects at the low nmol-per-g-level.
    Nitric oxide : biology and chemistry, 2010, May-15, Volume: 22, Issue:4

    Topics: Arginine; Blood Proteins; Enzyme Inhibitors; Female; Humans; Male

2010
Asymmetric dimethylarginine (ADMA) as a possible risk marker for ischemic stroke.
    Journal of the neurological sciences, 2010, Mar-15, Volume: 290, Issue:1-2

    Topics: Age Factors; Aged; Arginine; Biomarkers; Blood Glucose; Brain Ischemia; Cholesterol, LDL; Dyslipidemias; Female; Humans; Hypertension; Male; Middle Aged; Nitric Oxide; Predictive Value of Tests; Risk Factors; Sensitivity and Specificity; Stroke; Up-Regulation

2010
Arginine methylation of vasa protein is conserved across phyla.
    The Journal of biological chemistry, 2010, Mar-12, Volume: 285, Issue:11

    Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Arginine; Argonaute Proteins; Cell Cycle Proteins; DEAD-box RNA Helicases; Drosophila melanogaster; Drosophila Proteins; Female; Gene Expression Regulation, Enzymologic; Humans; Male; Methylation; Mice; Oogenesis; Phylogeny; Protein Methyltransferases; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Proteins; Ribonucleoproteins; Ribonucleoproteins, Small Nuclear; Spermatogenesis; Xenopus laevis; Xenopus Proteins

2010
Assessment of the relationship between asymmetric dimethylarginine and severity of erectile dysfunction and coronary artery disease.
    International urology and nephrology, 2010, Volume: 42, Issue:4

    Topics: Arginine; Coronary Artery Disease; Erectile Dysfunction; Humans; Male; Middle Aged; Severity of Illness Index; Surveys and Questionnaires

2010
A novel predictor of restenosis and adverse cardiac events: asymmetric dimethylarginine.
    Heart and vessels, 2010, Volume: 25, Issue:1

    Topics: Aged; Angioplasty, Balloon, Coronary; Arginine; Biomarkers; C-Reactive Protein; Coronary Angiography; Coronary Restenosis; Coronary Stenosis; Female; Humans; Male; Metals; Middle Aged; Natriuretic Peptide, Brain; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Prosthesis Design; Protein Precursors; Risk Assessment; Risk Factors; Stents; Time Factors; Treatment Outcome

2010
Asymmetric dimethylarginine, an endogenous NO synthase inhibitor, in human breast milk.
    Early human development, 2010, Volume: 86, Issue:2

    Topics: Arginine; Enzyme Inhibitors; Female; Gestational Age; Humans; Infant, Newborn; Male; Milk, Human; Nitric Oxide; Nitric Oxide Synthase; Postpartum Period

2010
Effect of aspirin on high glucose-induced senescence of endothelial cells.
    Chinese medical journal, 2009, Dec-20, Volume: 122, Issue:24

    Topics: Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Aspirin; Caveolin 1; Cells, Cultured; Cellular Senescence; Chromatography, High Pressure Liquid; Endothelial Cells; Flow Cytometry; Glucose; Humans; Immunoblotting; Immunoprecipitation; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Propane; Reactive Oxygen Species

2009
Inflammatory/oxidative stress during the first week after different types of cardiac surgery.
    Scandinavian cardiovascular journal : SCJ, 2010, Volume: 44, Issue:2

    Topics: Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Coronary Artery Bypass; Female; Heart Valve Prosthesis Implantation; Homocysteine; Humans; Inflammation; Inflammation Mediators; Interleukin-6; Male; Middle Aged; Oxidative Stress; Peroxidase; Time Factors; Treatment Outcome

2010
Increased levels of asymmetric dimethylarginine and C-reactive protein are associated with impaired vascular reactivity in essential hypertension.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2010, Volume: 32, Issue:1

    Topics: Adult; Aged; Arginine; Blood Flow Velocity; Brachial Artery; C-Reactive Protein; Female; Humans; Hypertension; Inflammation; Male; Middle Aged; Vasodilation

2010
A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease.
    Circulation research, 2010, Apr-02, Volume: 106, Issue:6

    Topics: Aged; Amidohydrolases; Arginine; Asian People; Binding Sites; Biomarkers; Case-Control Studies; Cells, Cultured; Chi-Square Distribution; China; Coronary Artery Disease; DNA Mutational Analysis; DNA-Binding Proteins; Female; Gene Expression Regulation, Enzymologic; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Mutagenesis, Insertional; Odds Ratio; Phenotype; Polymorphism, Genetic; Promoter Regions, Genetic; Risk Assessment; Risk Factors; Sequence Deletion; Stroke; Thrombosis; Transcription Factor MTF-1; Transcription Factors; Transcriptional Activation; Transfection

2010
Circulating angiopoietin-2 levels increase with progress of chronic kidney disease.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Volume: 25, Issue:8

    Topics: Adult; Aged; Angiopoietin-2; Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Chronic Disease; Disease Progression; Female; Glomerular Filtration Rate; Humans; Kidney Diseases; Male; Middle Aged; Nephrectomy; Risk Factors; Tissue Donors

2010
Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype.
    Blood cells, molecules & diseases, 2010, Apr-15, Volume: 44, Issue:4

    Topics: Adult; Albuminuria; Anemia, Sickle Cell; Arginine; beta-Thalassemia; Cholelithiasis; Female; Hemolysis; Humans; Hypertension, Pulmonary; Leg Ulcer; Male; Middle Aged; Nitric Oxide; Osteonecrosis; Phenotype; Priapism; Retinal Diseases; Sickle Cell Trait; Young Adult

2010
Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase.
    Journal of hypertension, 2010, Volume: 28, Issue:4

    Topics: Animals; Aorta, Thoracic; Arginine; Cattle; Cells, Cultured; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Endothelial Cells; Glycation End Products, Advanced; Hypoglycemic Agents; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Vascular Diseases; Vasodilation; Vasodilator Agents

2010
ADMA, C-reactive protein, and albuminuria in untreated essential hypertension: a cross-sectional study.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2010, Volume: 55, Issue:6

    Topics: Adult; Albuminuria; Arginine; Blood Pressure; C-Reactive Protein; Creatinine; Cross-Sectional Studies; Endothelium, Vascular; Female; Humans; Hypertension; Inflammation; Male; Middle Aged; Regression Analysis; Serum Albumin

2010
Early detection of cardiac involvement in systemic sclerosis assessed by tissue-Doppler echocardiography: relationship with neurohormonal activation and endothelial dysfunction.
    The Journal of rheumatology, 2010, Volume: 37, Issue:5

    Topics: Adult; Aged; Analysis of Variance; Arginine; Blood Flow Velocity; Echocardiography, Doppler; Endothelium, Vascular; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Myocardial Contraction; Natriuretic Peptide, Brain; Peptide Fragments; Prospective Studies; Scleroderma, Systemic; Ventricular Dysfunction, Left

2010
Effects of stent implementation on plasma levels of asymmetric dimethylarginine in patients with or without ST-segment elevation acute myocardial infarction.
    International journal of molecular medicine, 2010, Volume: 25, Issue:4

    Topics: Angioplasty, Balloon, Coronary; Arginine; Case-Control Studies; Coronary Angiography; Female; Humans; Male; Methylation; Middle Aged; Myocardial Infarction; Ornithine; Stents; Ultrasonography

2010
Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes.
    PloS one, 2010, Mar-01, Volume: 5, Issue:3

    Topics: Aged; Amidohydrolases; Arginine; Diabetes Mellitus, Type 2; Female; Gene Expression Regulation; Genotype; Haplotypes; Humans; Male; Mass Spectrometry; Middle Aged; Polymorphism, Genetic

2010
Melatonin prevents increased asymmetric dimethylarginine in young rats with bile duct ligation.
    Journal of pineal research, 2010, Volume: 48, Issue:3

    Topics: Amidohydrolases; Analysis of Variance; Animals; Arginine; Bile Ducts; Cholestasis, Intrahepatic; Disease Models, Animal; Immunohistochemistry; Kidney; Liver; Male; Melatonin; Oxidative Stress; Rats; Rats, Sprague-Dawley

2010
Adenoviral-mediated overexpression of DDAH improves vascular tone regulation.
    Vascular medicine (London, England), 2010, Volume: 15, Issue:3

    Topics: Adenoviridae; Amidohydrolases; Animals; Arginine; Carotid Arteries; Endothelial Cells; Gene Expression; Genetic Therapy; Green Fluorescent Proteins; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Peripheral Arterial Disease; Umbilical Veins; Vasoconstriction

2010
Effect of uric acid on coronary microvascular endothelial function in women: association with eGFR and ADMA.
    Journal of atherosclerosis and thrombosis, 2010, Mar-31, Volume: 17, Issue:3

    Topics: Aged; Angiography; Arginine; Endothelium, Vascular; Female; Glomerular Filtration Rate; Hemodynamics; Humans; Male; Microcirculation; Middle Aged; Oxidative Stress; Risk Factors; Sex Factors; Uric Acid

2010
Effects of long-term disease-modifying antirheumatic drugs on endothelial function in patients with early rheumatoid arthritis.
    Cardiovascular therapeutics, 2010, Volume: 28, Issue:5

    Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arginine; Arthritis, Rheumatoid; Biomarkers; Carotid Artery, Common; Case-Control Studies; Coronary Circulation; Coronary Vessels; Echocardiography, Doppler; Endothelium, Vascular; Female; Humans; Italy; Male; Methotrexate; Microcirculation; Middle Aged; Severity of Illness Index; Time Factors; Treatment Outcome

2010
Reduced proteinuria using ramipril in diabetic CKD stage 1 decreases circulating cell death receptor activators concurrently with ADMA. A novel pathophysiological pathway?
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Volume: 25, Issue:10

    Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Arginine; Chronic Disease; Diabetic Nephropathies; fas Receptor; Female; Humans; Kidney Diseases; Male; Middle Aged; Multivariate Analysis; Myostatin; Proteinuria; Ramipril

2010
Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine.
    The American journal of pathology, 2010, Volume: 176, Issue:5

    Topics: Amidohydrolases; Animals; Aorta; Apolipoproteins E; Arginine; Atherosclerosis; Blood Pressure; Cardiovascular Diseases; Humans; Male; Mice; Mice, Transgenic; Models, Genetic; Nitric Oxide; Risk

2010
Down but not out: candidate gene-based studies still have value in a world dominated by whole genome approaches.
    Circulation research, 2010, Apr-02, Volume: 106, Issue:6

    Topics: Amidohydrolases; Arginine; Asian People; Biomarkers; China; Coronary Artery Disease; Evidence-Based Medicine; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Phenotype; Polymorphism, Genetic; Promoter Regions, Genetic; Risk Factors; Stroke; Thrombosis

2010
Massive quantities of asymmetric dimethylarginine (ADMA) are incorporated in red blood cell proteins and may be released by proteolysis following hemolytic stress.
    Blood cells, molecules & diseases, 2010, Jun-15, Volume: 45, Issue:1

    Topics: Anemia, Sickle Cell; Arginine; Blood Proteins; Erythrocytes; Hemolysis; Humans

2010
The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels.
    Atherosclerosis, 2010, Volume: 211, Issue:2

    Topics: Aged; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Arginine; China; Coronary Artery Disease; Endothelium, Vascular; Female; Glutamic Acid; Humans; Lysine; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic; Risk Factors

2010
ADMA is a correlate of insulin resistance in early-stage diabetes independent of hs-CRP and body adiposity.
    Annales d'endocrinologie, 2010, Volume: 71, Issue:4

    Topics: Adiposity; Adult; Arginine; Biomarkers; Blood Glucose; C-Reactive Protein; Case-Control Studies; Cholesterol, HDL; Cholesterol, LDL; Creatinine; Diabetes Mellitus, Type 2; Fasting; Homeostasis; Humans; Inflammation; Insulin Resistance; Male; Middle Aged; Triglycerides

2010
Correlation between plasma asymmetric dimethylarginine and different types of coronary heart disease.
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2010, Volume: 35, Issue:4

    Topics: Acute Coronary Syndrome; Aged; Angina Pectoris; Arginine; Biomarkers; Coronary Disease; Female; Humans; Male; Middle Aged; Nitric Oxide; von Willebrand Factor

2010
Association between exaggerated blood pressure response to exercise and serum asymmetric dimethylarginine levels.
    Circulation journal : official journal of the Japanese Circulation Society, 2010, Volume: 74, Issue:6

    Topics: Adult; Arginine; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cardiovascular Diseases; Case-Control Studies; Chromatography, High Pressure Liquid; Exercise; Exercise Test; Female; Humans; Hypertension; Male; Middle Aged; Predictive Value of Tests

2010
Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers.
    International journal of cancer, 2011, Feb-01, Volume: 128, Issue:3

    Topics: Anthracenes; Arginine; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Line, Tumor; DNA Replication; Enzyme-Linked Immunosorbent Assay; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Neoplasms; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Propane; Protein-Arginine N-Methyltransferases; Repressor Proteins; RNA, Small Interfering; Urinary Bladder Neoplasms

2011
Effects of angiotensin type 1 receptor blockade on arginine and ADMA synthesis and metabolic pathways in fawn-hooded hypertensive rats.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Volume: 25, Issue:11

    Topics: Amidohydrolases; Angiotensin II Type 1 Receptor Blockers; Animals; Arginine; Biphenyl Compounds; Citrulline; Hypertension; Irbesartan; Male; Metabolic Networks and Pathways; Nitric Oxide; Rats; Tetrazoles

2010
Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism.
    Circulation research, 2010, Jul-09, Volume: 107, Issue:1

    Topics: Angiogenesis Inhibitors; Arginine; Coronary Artery Disease; Gene Expression Regulation; Humans; MicroRNAs; Neovascularization, Pathologic; Stem Cells

2010
Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics.
    Toxicology and applied pharmacology, 2010, Aug-15, Volume: 247, Issue:1

    Topics: Arginine; Biomarkers; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Embryonic Stem Cells; Forecasting; Humans; Metabolomics; Models, Statistical; Teratogens; Toxicity Tests

2010
Plasma apelin and ADMA Levels in patients with essential hypertension.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2010, Volume: 32, Issue:3

    Topics: Adult; Apelin; Arginine; Biomarkers; Blood Pressure; Body Mass Index; Case-Control Studies; Endothelium, Vascular; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Hypertension; Intercellular Signaling Peptides and Proteins; Male; Statistics, Nonparametric; Young Adult

2010
[Prevalence of cardiovascular disease in uraemia and relevance of cardiovascular risk factors].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2010, Volume: 30, Issue:3

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Blood Proteins; Cardiovascular Diseases; Comorbidity; Cross-Sectional Studies; Diabetes Complications; Female; Humans; Hyperhomocysteinemia; Hyperlipidemias; Kidney Transplantation; Male; Middle Aged; Postoperative Complications; Prevalence; Risk Factors; Smoking; Stroke Volume; Ultrasonography; Uremia

2010
Left atrial volume and N-terminal pro-B type natriuretic peptide are associated with elevated pulmonary artery pressure in patients with systemic sclerosis.
    Clinical rheumatology, 2010, Volume: 29, Issue:9

    Topics: Aged; Arginine; Biomarkers; Blood Pressure; Cross-Sectional Studies; Female; Follow-Up Studies; Heart Atria; Humans; Hypertension, Pulmonary; Male; Middle Aged; Multivariate Analysis; Natriuretic Peptide, Brain; Peptide Fragments; Predictive Value of Tests; Prospective Studies; Pulmonary Artery; Scleroderma, Systemic; Ultrasonography; Ventricular Dysfunction, Right

2010
Neuroprotective effect of asymmetric dimethylarginine against 1-methyl-4-phenylpyridinium ion-induced damage in PC12 cells.
    Clinical and experimental pharmacology & physiology, 2010, Volume: 37, Issue:5-6

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Arginine; Cell Culture Techniques; Cell Survival; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; PC12 Cells; Rats; Reactive Oxygen Species

2010
HPLC determination of plasma dimethylarginines: method validation and preliminary clinical application.
    Clinica chimica acta; international journal of clinical chemistry, 2010, Nov-11, Volume: 411, Issue:21-22

    Topics: Adolescent; Adult; Aged; Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Creatine; Endothelium, Vascular; Female; Glomerular Filtration Rate; Humans; Kidney Function Tests; Male; Middle Aged; Renal Insufficiency, Chronic; Young Adult

2010
Relationships between dimethylarginine and the presence of vertebral fractures in type 2 diabetes mellitus.
    Clinical endocrinology, 2010, Volume: 73, Issue:4

    Topics: Adult; Aged; Arginine; Bone Density; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Risk Factors; Spinal Fractures

2010
The role of the DDAH-ADMA pathway in the protective effect of resveratrol analog BTM-0512 on gastric mucosal injury.
    Canadian journal of physiology and pharmacology, 2010, Volume: 88, Issue:5

    Topics: Amidohydrolases; Animals; Anti-Ulcer Agents; Arginine; Disease Models, Animal; Ethanol; Hydroxyl Radical; Male; Molecular Structure; Nitric Oxide; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Stomach Ulcer; Superoxides

2010
Simvastatin improves epithelial dysfunction and airway hyperresponsiveness: from asymmetric dimethyl-arginine to asthma.
    American journal of respiratory cell and molecular biology, 2011, Volume: 44, Issue:4

    Topics: Airway Remodeling; Animals; Arginine; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Chronic Disease; Disease Models, Animal; Epithelial Cells; Epithelium; Lung; Male; Mice; Mice, Inbred BALB C; Mucus; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrosation; Pneumonia; Simvastatin; Stress, Physiological

2011
Interethnic differences in ADMA concentrations and negative association with nitric oxide formation in preeclampsia.
    Clinica chimica acta; international journal of clinical chemistry, 2010, Oct-09, Volume: 411, Issue:19-20

    Topics: Adult; Arginine; Biomarkers; Black People; Case-Control Studies; Ethnicity; Female; Humans; Nitric Oxide; Nitrites; Pre-Eclampsia; Pregnancy; White People; Young Adult

2010
Differential sensitivity of basal and acetylcholine-induced activity of nitric oxide to blockade by asymmetric dimethylarginine in the rat aorta.
    British journal of pharmacology, 2010, Volume: 160, Issue:6

    Topics: Acetylcholine; Animals; Aorta; Arginine; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Nitric Oxide; omega-N-Methylarginine; Phenylephrine; Rats; Rats, Wistar

2010
Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and plasma concentrations of asymmetric dimethylarginine in Turkish pre-eclamptic women without fetal growth retardation.
    The journal of obstetrics and gynaecology research, 2010, Volume: 36, Issue:3

    Topics: Adult; Analysis of Variance; Arginine; Chromatography, High Pressure Liquid; Female; Fetal Growth Retardation; Genetic Association Studies; Genotype; Humans; Nitric Oxide Synthase Type III; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Pre-Eclampsia; Pregnancy; Turkey

2010
Alpha-lipoic acid activates dimethylarginine dimethylaminohydrolase in cultured endothelial cells.
    Biochemical and biophysical research communications, 2010, Aug-06, Volume: 398, Issue:4

    Topics: Amidohydrolases; Animals; Arginine; Cell Line, Tumor; Endothelial Cells; Enzyme Induction; Mice; Promoter Regions, Genetic; STAT3 Transcription Factor; Thioctic Acid

2010
FGF-23 and vascular dysfunction in patients with stage 3 and 4 chronic kidney disease.
    Kidney international, 2010, Volume: 78, Issue:7

    Topics: Adult; Arginine; Chronic Disease; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Forearm; Humans; Kidney Diseases; Linear Models; Male; Middle Aged; Multivariate Analysis; Nitric Oxide; Risk Factors; Vasodilation

2010
A miR-thless perspective: how asymmetric dimethylarginine impairs the functions of angiogenic progenitor cells.
    Circulation research, 2010, Jul-09, Volume: 107, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; Arginine; Humans; MicroRNAs; Risk Factors; Stem Cells

2010
Increased production of asymmetric dimethylarginine (ADMA) in ankylosing spondylitis: association with other clinical and laboratory parameters.
    Joint bone spine, 2011, Volume: 78, Issue:2

    Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Female; Humans; Male; Middle Aged; Osteoarthritis, Hip; Osteoarthritis, Knee; Risk Factors; Spondylitis, Ankylosing

2011
Antiretrovirals induce endothelial dysfunction via an oxidant-dependent pathway and promote neointimal hyperplasia.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 117, Issue:2

    Topics: Animals; Anti-HIV Agents; Arginine; Atherosclerosis; Biomarkers; Cell Proliferation; Drug Therapy, Combination; Endothelium, Vascular; Free Radical Scavengers; Hyperplasia; Indinavir; Male; Metalloporphyrins; Mice; Mice, Inbred C57BL; Neointima; Zidovudine

2010
Adipokines, endothelial dysfunction and nutritional status in peritoneal dialysis patients.
    Scandinavian journal of urology and nephrology, 2010, Volume: 44, Issue:6

    Topics: Adiponectin; Adult; Aged; Aldehydes; Arginine; Biomarkers; Body Mass Index; Body Weight; C-Reactive Protein; Cardiovascular Diseases; Endothelium; Female; Humans; Inflammation; Interleukin-6; Leptin; Lipoproteins, LDL; Male; Malnutrition; Malondialdehyde; Middle Aged; Nutritional Status; Oxidative Stress; Peritoneal Dialysis; Risk Factors; Tumor Necrosis Factor-alpha

2010
Association between plasma asymmetrical dimethylarginine activity and severity of aortic valve stenosis.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2011, Volume: 12, Issue:2

    Topics: Aged; Aortic Valve Stenosis; Arginine; Biomarkers; Chi-Square Distribution; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Predictive Value of Tests; Severity of Illness Index; Turkey; Up-Regulation

2011
Asymmetric dimethylarginine in hemodialysis, hemodiafiltration, and peritoneal dialysis.
    Artificial organs, 2010, Volume: 34, Issue:5

    Topics: Aged; Arginine; Female; Glycation End Products, Advanced; Homocysteine; Humans; Male; Middle Aged; Oxidative Stress; Peritoneal Dialysis; Renal Dialysis

2010
Immunoregulatory effects of the flavonol quercetin in vitro and in vivo.
    European journal of nutrition, 2011, Volume: 50, Issue:3

    Topics: Adult; Animals; Anti-Inflammatory Agents; Apoptosis; Arginine; Cell Adhesion; Cell Differentiation; Cell Line; Dendritic Cells; Endocytosis; Endothelial Cells; Humans; Leukocytes; Lipoproteins, LDL; Male; Mice; Mice, Inbred C57BL; Monocytes; NF-kappa B; Quercetin; Up-Regulation

2011
Levels of asymmetrical dimethylarginine are predictive of brachial artery flow-mediated dilation 6 years later. The Cardiovascular Risk in Young Finns Study.
    Atherosclerosis, 2010, Volume: 212, Issue:2

    Topics: Adult; Arginine; Brachial Artery; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Cohort Studies; Endothelium, Vascular; Female; Finland; Humans; Male; Middle Aged; Multivariate Analysis; Risk Factors

2010
Modulatory role of the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine (ADMA), in morphine tolerance and dependence in mice.
    Journal of neural transmission (Vienna, Austria : 1996), 2010, Volume: 117, Issue:9

    Topics: Animals; Arginine; Chromatography, High Pressure Liquid; Drug Tolerance; Homoarginine; Male; Mice; Mice, Inbred BALB C; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Pain Measurement

2010
Predictors of the intima-media thickness of carotid artery in asymptomatic newly detected severe hypercholesterolemic patients.
    Clinical physiology and functional imaging, 2010, Volume: 30, Issue:4

    Topics: Adult; Age Factors; Arginine; Biomarkers; Bulgaria; Carotid Arteries; Carotid Artery Diseases; Case-Control Studies; Cell Adhesion Molecules; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Homocysteine; Humans; Hypercholesterolemia; Linear Models; Lipids; Male; Predictive Value of Tests; Risk Assessment; Risk Factors; Severity of Illness Index; Tunica Intima; Tunica Media; Ultrasonography

2010
The DDAH-ADMA pathway. Proceedings of the 4th International Symposium on ADMA. August 28-30, 2008. Bregenz, Austria.
    Pharmacological research, 2009, Volume: 60, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Humans

2009
Evaluation of asymmetric dimethylarginine, nitric oxide levels and associated independent variables in obese and lean patients with polycystic ovarian syndrome.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2011, Volume: 27, Issue:9

    Topics: Adolescent; Adult; Arginine; Biomarkers; Blood Glucose; Cardiovascular Diseases; Cholesterol; Female; Hormones; Humans; Nitric Oxide; Obesity; Polycystic Ovary Syndrome; Risk Factors; Young Adult

2011
Angiotensin II and NADPH oxidase increase ADMA in vascular smooth muscle cells.
    Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:3

    Topics: Analysis of Variance; Angiotensin II; Animals; Arginine; Benzimidazoles; Biphenyl Compounds; Blotting, Western; Cells, Cultured; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Rats; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Tetrazoles

2010
Bile duct ligation in developing rats: temporal progression of liver, kidney, and brain damage.
    Journal of pediatric surgery, 2010, Volume: 45, Issue:8

    Topics: Animals; Arginine; Bile Ducts; Brain; Brain Diseases; Cholestasis; Disease Progression; End Stage Liver Disease; Kidney; Kidney Diseases; Laparotomy; Ligation; Lipocalins; Liver; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Time Factors

2010
Do sea stars have low ADMA levels? High ADMA and low EPC count--duo infernal for the kidney.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010, Volume: 25, Issue:10

    Topics: Animals; Arginine; Cell Count; Chronic Disease; Endothelial Cells; Glomerular Filtration Rate; Humans; Kidney Diseases; Stem Cells

2010
Impact of reversible myocardial ischaemia on nitric oxide and asymmetric dimethylarginine production in patients with high risk for coronary heart disease.
    Medical science monitor : international medical journal of experimental and clinical research, 2010, Volume: 16, Issue:9

    Topics: Arginine; Coronary Disease; Diabetes Complications; Exercise Tolerance; Female; Humans; Male; Middle Aged; Nitric Oxide; Risk Factors; Ultrasonography

2010
Circulating levels of asymmetric dimethylarginine are an independent risk factor for left ventricular hypertrophy and predict cardiovascular events in pre-dialysis patients with chronic kidney disease.
    European journal of internal medicine, 2010, Volume: 21, Issue:5

    Topics: Adult; Arginine; Female; Follow-Up Studies; Humans; Hypertrophy, Left Ventricular; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Prospective Studies; Renal Dialysis; Renal Insufficiency, Chronic; Risk Factors

2010
Simultaneous quantitative determination of N(G),N(G)-dimethyl-L-arginine or asymmetric dimethylarginine and related pathway's metabolites in biological fluids by ultrahigh-performance liquid chromatography/electrospray ionization-tandem mass spectrometry.
    Analytica chimica acta, 2010, Sep-16, Volume: 677, Issue:2

    Topics: Adult; Arginine; Body Fluids; Chromatography, High Pressure Liquid; Citrulline; Enzyme Inhibitors; Humans; Infant, Newborn; Middle Aged; Nitric Oxide; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2010
Impaired endothelial function and microvascular asymmetrical dimethylarginine in angiotensin II-infused rats: effects of tempol.
    Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:5

    Topics: Analysis of Variance; Angiotensin II; Animals; Antioxidants; Arginine; Arterioles; Cyclic N-Oxides; Endothelium, Vascular; Male; Malondialdehyde; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Spin Labels; Vasoconstrictor Agents

2010
Asymmetric dimethylarginine (ADMA) induces chronic kidney disease through a mechanism involving collagen and TGF-β1 synthesis.
    The Journal of pathology, 2011, Volume: 223, Issue:1

    Topics: Animals; Arginine; Collagen; Endothelin-1; Enzyme Inhibitors; Fibrosis; Gene Expression Regulation; Hypertension; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Renal Insufficiency, Chronic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta1

2011
The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism.
    Cell cycle (Georgetown, Tex.), 2010, Sep-01, Volume: 9, Issue:17

    Topics: 3-Hydroxybutyric Acid; Animals; Arginine; Autophagy; Biomarkers; Breast Neoplasms; Caveolin 1; Female; Gene Expression Profiling; Humans; Mice; MicroRNAs; Models, Biological; Oxidative Stress; Stromal Cells

2010
Relationship between L-arginine/asymmetric dimethylarginine, homocysteine, folic acid, vitamin B levels, and coronary artery ectasia.
    Coronary artery disease, 2010, Volume: 21, Issue:8

    Topics: Aged; Arginine; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Dilatation, Pathologic; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Prospective Studies; Turkey; Vitamin B Complex

2010
Plasma levels of asymmetric dimethylarginine in patients with biopsy-proven nonalcoholic fatty liver disease.
    Metabolism: clinical and experimental, 2011, Volume: 60, Issue:6

    Topics: Adult; Arginine; Biopsy; Blood Glucose; Chromatography, High Pressure Liquid; Fatty Liver; Female; Glomerular Filtration Rate; Humans; Insulin Resistance; Liver; Male; Middle Aged

2011
Negative association of L-arginine methylation products with oocyte numbers.
    Human reproduction (Oxford, England), 2010, Volume: 25, Issue:12

    Topics: Adult; Arginine; Female; Fertilization in Vitro; Follicular Fluid; Humans; Methylation; Oocytes; Ovulation Induction

2010
C-terminus of heat shock protein 70-interacting protein-dependent GTP cyclohydrolase I degradation in lambs with increased pulmonary blood flow.
    American journal of respiratory cell and molecular biology, 2011, Volume: 45, Issue:1

    Topics: Animals; Anthracenes; Arginine; Blood Flow Velocity; Disease Models, Animal; Female; GTP Cyclohydrolase; Heart Defects, Congenital; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Lung; Nitric Oxide; Nitric Oxide Synthase; Propane; Proteasome Endopeptidase Complex; Sheep

2011
Sequential change of asymmetric dimethylarginine levels after initiation of peritoneal dialysis in patients with end-stage renal disease.
    Nephrology (Carlton, Vic.), 2010, Volume: 15, Issue:6

    Topics: Aged; Arginine; Biomarkers; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nutritional Status; Peritoneal Dialysis, Continuous Ambulatory; Time Factors; Treatment Outcome

2010
Asymmetric dimethylarginine as a risk marker for early-onset ischemic stroke in Indian population.
    Clinica chimica acta; international journal of clinical chemistry, 2011, Jan-14, Volume: 412, Issue:1-2

    Topics: Adolescent; Adult; Analysis of Variance; Arginine; Biomarkers; Brain Ischemia; Case-Control Studies; Female; Humans; India; Linear Models; Male; Middle Aged; Risk; Stroke; Time Factors; Young Adult

2011
Transplantation of endothelial progenitor cells overexpressing endothelial nitric oxide synthase enhances inhibition of neointimal hyperplasia and restores endothelium-dependent vasodilatation.
    Microvascular research, 2011, Volume: 81, Issue:1

    Topics: Acetylcholine; Animals; Arginine; Bone Marrow Cells; Carotid Artery Injuries; Catheterization; Cell Differentiation; Cell Proliferation; Endothelial Cells; Humans; Hyperplasia; Lipoproteins, LDL; Male; Neointima; Nitric Oxide; Nitric Oxide Synthase Type III; Plant Lectins; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Stem Cells; Transfection; Vasodilation; von Willebrand Factor

2011
Asymmetric dimethylarginine potentiates lung inflammation in a mouse model of allergic asthma.
    American journal of physiology. Lung cellular and molecular physiology, 2010, Volume: 299, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enzyme Inhibitors; Epithelial Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide Synthase Type II; Nitrites; Ovalbumin; Pneumonia; Respiratory Mucosa

2010
The impact of rapid atrial pacing on ADMA and endothelial NOS.
    International journal of cardiology, 2012, Jan-26, Volume: 154, Issue:2

    Topics: Aged; Animals; Arginine; Atrial Fibrillation; Calcium-Binding Proteins; Disease Models, Animal; Endothelium, Vascular; Female; Heart Rate; Human Umbilical Vein Endothelial Cells; Humans; Male; Middle Aged; Myocardial Contraction; Nitric Oxide Synthase Type III; Oxidative Stress; Pacemaker, Artificial; Risk Factors; Swine; Tachycardia; Ventricular Function, Left

2012
Acute lung injury-induced collagen deposition is associated with elevated asymmetric dimethylarginine and arginase activity.
    Shock (Augusta, Ga.), 2011, Volume: 35, Issue:3

    Topics: Acute Lung Injury; Amidohydrolases; Animals; Arginase; Arginine; Blotting, Western; Collagen; Female; Lipid Peroxidation; Nitrates; Nitrites; Sheep

2011
Plasma asymmetric dimethylarginine (ADMA) levels and atherosclerotic disease in ankylosing spondylitis: a cross-sectional study.
    Clinical rheumatology, 2011, Volume: 30, Issue:1

    Topics: Adult; Arginine; Arteries; Atherosclerosis; Carotid Artery, Common; Cross-Sectional Studies; Electrophoresis, Capillary; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Risk Factors; Spondylitis, Ankylosing

2011
Melatonin prevents hypertension and increased asymmetric dimethylarginine in young spontaneous hypertensive rats.
    Journal of pineal research, 2010, Volume: 49, Issue:4

    Topics: Analysis of Variance; Animals; Arginine; Blood Pressure; Blotting, Western; Body Weight; Citrulline; Histocytochemistry; Hypertension; Male; Melatonin; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Organ Size; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY

2010
Ramipril retards development of aortic valve stenosis in a rabbit model: mechanistic considerations.
    British journal of pharmacology, 2011, Volume: 162, Issue:3

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic Valve; Aortic Valve Stenosis; Arginine; Carrier Proteins; Disease Models, Animal; Disease Progression; Echocardiography; Enzyme Inhibitors; Ergocalciferols; Humans; Male; Rabbits; Ramipril; Vitamins

2011
Asymmetric dimethylarginine concentrations are elevated in women with gestational diabetes.
    Endocrine, 2010, Volume: 38, Issue:1

    Topics: Adolescent; Adult; Arginine; C-Reactive Protein; Diabetes, Gestational; Female; Homocysteine; Humans; Insulin Resistance; Pregnancy; Pregnancy Trimester, Third; Young Adult

2010
Chitotriosidase activity predicts endothelial dysfunction in type-2 diabetes mellitus.
    Endocrine, 2010, Volume: 37, Issue:3

    Topics: Adult; Arginine; Diabetes Mellitus, Type 2; Endothelium; Female; Hexosaminidases; Humans; Male; Middle Aged; Young Adult

2010
Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes.
    European heart journal, 2011, Volume: 32, Issue:10

    Topics: Animals; Arginine; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Heart Failure; Humans; Mice; Mice, Knockout; MicroRNAs; Myocytes, Cardiac; Nitric Oxide Synthase Type III; Rats; STAT3 Transcription Factor; Ubiquitin-Conjugating Enzymes; Up-Regulation

2011
Characterization of C-alkyl amidines as bioavailable covalent reversible inhibitors of human DDAH-1.
    ChemMedChem, 2011, Jan-03, Volume: 6, Issue:1

    Topics: Amidines; Aminohydrolases; Arginine; Biological Availability; Calorimetry, Differential Scanning; Cell Line; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase

2011
The alteration of asymmetric dimetilarginine (ADMA) levels in cardiac and gastrocnemius muscles following radioactive iodine application in guinea pigs and the effect of L-carnitine on this alteration.
    International journal of radiation biology, 2011, Volume: 87, Issue:1

    Topics: Animals; Arginine; Carnitine; Guinea Pigs; Heart; Homoarginine; Iodine Radioisotopes; Male; Muscle, Skeletal; Myocardium; Radiation-Protective Agents; Thyroid Hormones

2011
Serum asymmetric dimethylarginine levels in normotensive obese individuals.
    Medical science monitor : international medical journal of experimental and clinical research, 2010, Volume: 16, Issue:11

    Topics: Adult; Arginine; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Male; Middle Aged; Obesity; Risk Factors

2010
Low levels of asymmetric dimethylarginine in children with diabetes mellitus type I compared with healthy children.
    The Journal of pediatrics, 2011, Volume: 158, Issue:4

    Topics: Adolescent; Arginine; Child; Child, Preschool; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Female; Glycated Hemoglobin; Humans; Lipoproteins, HDL; Male; Nitric Oxide Synthase; Oxidative Stress; Young Adult

2011
The adipose tissue gene expression in mice with different nitric oxide availability.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2010, Volume: 61, Issue:5

    Topics: Adipose Tissue; Adipose Tissue, Brown; Adipose Tissue, White; Amidohydrolases; Animals; Arginine; Female; Gene Expression; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III

2010
[Plasma asymmetric dimethylarginine and cystatin C levels in patients with coronary artery disease].
    Zhonghua xin xue guan bing za zhi, 2010, Volume: 38, Issue:9

    Topics: Aged; Arginine; Case-Control Studies; Coronary Disease; Cystatin C; Female; Humans; Male; Middle Aged

2010
[Asymmetric dimethylarginine (ADMA) in children with diabetes type 1].
    Pediatric endocrinology, diabetes, and metabolism, 2010, Volume: 16, Issue:3

    Topics: Adolescent; Adult; Arginine; Biomarkers; Child; Comorbidity; Diabetes Mellitus, Type 1; Endothelium, Vascular; Female; Humans; Hypertension; Male; Nitric Oxide Synthase; Young Adult

2010
Association of asymmetric dimethylarginine with severity of kidney injury and decline in kidney function in IgA nephropathy.
    American journal of nephrology, 2011, Volume: 33, Issue:1

    Topics: Adult; Arginine; Case-Control Studies; Chronic Disease; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Glomerulonephritis, IGA; Humans; Kidney; Kidney Function Tests; Male; Regression Analysis; Retrospective Studies; Smoking

2011
Posttranslational arginine methylation of lamin A/C during myoblast fusion.
    Biochimica et biophysica acta, 2011, Volume: 1814, Issue:2

    Topics: Amino Acid Sequence; Animals; Arginine; Blotting, Western; Cell Differentiation; Cells, Cultured; Electrophoresis, Gel, Two-Dimensional; Lamin Type A; Membrane Fusion; Methylation; Molecular Sequence Data; Muscle Development; Muscle Fibers, Skeletal; Myoblasts, Skeletal; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2011
Dimethylarginines and serotonin in the blood of spontaneously hypertensive rats.
    Bulletin of experimental biology and medicine, 2009, Volume: 148, Issue:6

    Topics: Animals; Arginine; Hydroxyindoleacetic Acid; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Wistar; Serotonin

2009
Nitric oxide synthase inhibitors and cerebral vasospasm.
    Acta neurochirurgica. Supplement, 2011, Volume: 110, Issue:Pt 1

    Topics: Animals; Arginine; Citrulline; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; S-Adenosylmethionine; Vasospasm, Intracranial

2011
Down syndrome patients with pulmonary hypertension have elevated plasma levels of asymmetric dimethylarginine.
    European journal of pediatrics, 2011, Volume: 170, Issue:7

    Topics: Arginine; Biomarkers; Down Syndrome; Female; Humans; Hypertension, Pulmonary; Infant; Male; Nitrates; Nitrites

2011
Asymmetric dimethylarginine levels in essential thrombocythemia--a retrospective analysis.
    Annals of hematology, 2011, Volume: 90, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Body Mass Index; Cohort Studies; Disease Progression; Humans; Middle Aged; Retrospective Studies; Thrombocythemia, Essential; Young Adult

2011
Asymmetric dimethylarginine as a risk factor for cardiovascular disease in Japanese patients with type 2 diabetes mellitus.
    Clinical endocrinology, 2011, Volume: 74, Issue:4

    Topics: Aged; Arginine; Asian People; Cardiovascular Diseases; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Regression Analysis; Risk Factors

2011
Asymmetric dimethylarginine in ELBW newborns exposed to chorioamnionitis.
    Early human development, 2011, Volume: 87, Issue:2

    Topics: Arginine; Chorioamnionitis; Female; Gestational Age; Humans; Infant, Extremely Low Birth Weight; Infant, Newborn; Male; Osmolar Concentration; Pregnancy; Prenatal Exposure Delayed Effects

2011
Serum asymmetric dimethylarginine (ADMA), homocysteine, vitamin B(12), folate levels, and lipid profiles in epileptic children treated with valproic acid.
    European journal of pediatrics, 2011, Volume: 170, Issue:7

    Topics: Adolescent; Anticonvulsants; Arginine; Biomarkers; Case-Control Studies; Child; Child, Preschool; Cholesterol; Cross-Sectional Studies; Drug Administration Schedule; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Triglycerides; Valproic Acid; Vitamin B 12; Vitamin B Complex

2011
Association between asymmetric dimethylarginine and indices of vascular function in patients with essential hypertension.
    Blood pressure, 2011, Volume: 20, Issue:2

    Topics: Adult; Arginine; Cardiovascular System; Endothelium, Vascular; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nitric Oxide Synthase; Regression Analysis; Tunica Intima

2011
Asymmetric dimethylarginine in normotensive pregnant women with isolated fetal intrauterine growth restriction: a comparison with preeclamptic women with and without intrauterine growth restriction.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2011, Volume: 24, Issue:7

    Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Female; Fetal Growth Retardation; Humans; Pre-Eclampsia; Pregnancy

2011
Time course of asymmetric dimethylarginine (ADMA) and oxidative stress in fructose-hypertensive rats: a model related to metabolic syndrome.
    Atherosclerosis, 2011, Volume: 214, Issue:2

    Topics: Animals; Aorta; Arginine; Blood Glucose; Blood Pressure; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fructose; Heart Rate; Hypertension; Male; Metabolic Syndrome; NADPH Oxidases; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents

2011
Urinary asymmetric dimethylarginine (ADMA) is a predictor of mortality risk in patients with coronary artery disease.
    International journal of cardiology, 2012, May-03, Volume: 156, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Predictive Value of Tests; Risk Factors

2012
Plasma dimethylarginines during the acute inflammatory response.
    European journal of clinical investigation, 2011, Volume: 41, Issue:6

    Topics: Acute-Phase Reaction; Aged; Aged, 80 and over; Arginine; Arthroplasty, Replacement, Knee; Cohort Studies; Dimethylamines; Enzyme Inhibitors; Female; Humans; Inflammation; Knee Joint; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Postoperative Complications

2011
Asymmetric dimethylarginine as an independent risk marker for mortality in ambulatory patients with peripheral arterial disease.
    Journal of internal medicine, 2011, Volume: 269, Issue:3

    Topics: Aged; Arginine; Biomarkers; Cardiovascular Diseases; Cerebrovascular Disorders; Enzyme Inhibitors; Epidemiologic Methods; Female; Germany; Humans; Male; Nitric Oxide Synthase; Peripheral Arterial Disease; Prognosis

2011
Asymmetric dimethylarginine upregulates the expression of ACAT-1 in THP-1 macrophage-derived foam cells.
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2010, Volume: 30, Issue:12

    Topics: Acetyl-CoA C-Acetyltransferase; Arginine; Cell Line; Cholesterol; Foam Cells; Humans; Macrophages; Monocytes; RNA, Messenger; Up-Regulation

2010
Serum paraoxonase 1 activity, asymmetric dimethylarginine levels, and brachial artery flow-mediated dilatation in women with polycystic ovary syndrome.
    Fertility and sterility, 2011, Mar-01, Volume: 95, Issue:3

    Topics: Adult; Arginine; Aryldialkylphosphatase; Biomarkers; Blood Flow Velocity; Brachial Artery; Case-Control Studies; Endothelium, Vascular; Female; Hormones; Humans; Polycystic Ovary Syndrome; Prospective Studies; Risk Factors; Ultrasonography; Vasodilation; Young Adult

2011
The effects of endothelial dysfunction and inflammation on slow coronary flow.
    Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2010, Volume: 38, Issue:5

    Topics: Arginine; Blood Flow Velocity; C-Reactive Protein; Case-Control Studies; Coronary Angiography; Coronary Vessels; Dilatation, Pathologic; Endothelium, Vascular; Female; Humans; Inflammation; Logistic Models; Male; Middle Aged; No-Reflow Phenomenon; Ultrasonography

2010
Dimethylarginine dimethylaminohydrolase 1 modulates endothelial cell growth through nitric oxide and Akt.
    Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:4

    Topics: Amidohydrolases; Animals; Arginine; Cell Movement; Cell Proliferation; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Humans; Mice; Mice, Knockout; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; ras Proteins; RNA Interference; Signal Transduction; Time Factors; Tissue Culture Techniques; Transfection

2011
3,4,5,6-Tetrahydroxyxanthone preserves intercellular communication by reduction of the endogenous nitric oxide synthase inhibitor level.
    Journal of Asian natural products research, 2011, Volume: 13, Issue:1

    Topics: Arginine; Cell Survival; Connexin 43; Lysophosphatidylcholines; Molecular Structure; Nitric Oxide Synthase; Reactive Oxygen Species; Xanthones

2011
Effect of asymmetric dimethylarginine on MIF expression and TNF-α and IL-8 secretion in THP-1 monocytes-derived macrophages.
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2011, Volume: 31, Issue:1

    Topics: Arginine; Cell Differentiation; Cell Line; Humans; Interleukin-8; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Macrophages; Monocytes; Phenanthrenes; RNA, Messenger; Tumor Necrosis Factor-alpha

2011
Elevated concentrations of Nɛ-homocysteinyl-lysine isopeptide in acute myocardial infarction: links with ADMA formation.
    Clinical chemistry and laboratory medicine, 2011, Volume: 49, Issue:4

    Topics: Arginine; Autoantibodies; Dipeptides; Endothelium; Female; Fibrinolysis; Humans; Male; Middle Aged; Myocardial Infarction; Oxidative Stress; Thrombin

2011
Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with cystic fibrosis.
    American journal of respiratory and critical care medicine, 2011, May-15, Volume: 183, Issue:10

    Topics: Adolescent; Airway Obstruction; Arginine; Child; Chromatography, Liquid; Cystic Fibrosis; Female; Humans; Lung; Male; Nitric Oxide; Respiratory System; Sputum; Tandem Mass Spectrometry

2011
Carotid restenosis is associated with plasma ADMA concentrations in carotid endarterectomy patients.
    Clinical chemistry and laboratory medicine, 2011, Volume: 49, Issue:5

    Topics: Aged; Arginine; Carotid Artery Diseases; Cohort Studies; Cysteine; Endarterectomy, Carotid; Female; Homocysteine; Humans; Male; Middle Aged; Regression Analysis

2011
Asymmetric dimethylarginine (ADMA) levels are increased in patients with fibromyalgia: correlation with tumor necrosis factor-α (TNF-α) and 8-iso-prostaglandin F(2α) (8-iso-PGF(2α)).
    Clinical biochemistry, 2011, Volume: 44, Issue:5-6

    Topics: Adult; Arginine; Dinoprost; Female; Fibromyalgia; Humans; Male; Middle Aged; Surveys and Questionnaires; Tumor Necrosis Factor-alpha

2011
Acute effects of hyperglycaemia on asymmetric dimethylarginine (ADMA), adiponectin and inflammatory markers (IL-6, hs-CRP) in overweight and obese women with metabolic syndrome.
    British journal of biomedical science, 2010, Volume: 67, Issue:4

    Topics: Adiponectin; Adult; Aged; Arginine; Biomarkers; Female; Humans; Hyperglycemia; Interleukin-6; Metabolic Syndrome; Middle Aged; Obesity; Young Adult

2010
Asymmetric dimethylarginine in young people with Type 1 diabetes: a paradoxical association with HbA(1c).
    Diabetic medicine : a journal of the British Diabetic Association, 2011, Volume: 28, Issue:6

    Topics: Adolescent; Albuminuria; Arginine; Biomarkers; Blood Glucose; Cardiovascular Diseases; Child; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Female; Glycated Hemoglobin; Humans; Longitudinal Studies; Male; Risk Factors

2011
Effects of asymmetric dimethylarginine on bovine retinal capillary endothelial cell proliferation, reactive oxygen species production, permeability, intercellular adhesion molecule-1, and occludin expression.
    Molecular vision, 2011, Feb-01, Volume: 17

    Topics: Animals; Antioxidants; Arginine; Blotting, Western; Cattle; Cell Proliferation; Endothelial Cells; Enzyme Inhibitors; Intercellular Adhesion Molecule-1; Membrane Proteins; Occludin; Permeability; Reactive Oxygen Species; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; Tight Junctions

2011
The L-arginine-asymmetric dimethylarginine ratio is strongly related to the severity of chronic heart failure. No effects of exercise training.
    Journal of cardiac failure, 2011, Volume: 17, Issue:2

    Topics: Aged; Aged, 80 and over; Arginine; Endothelium, Vascular; Exercise Therapy; Exercise Tolerance; Female; Flow Cytometry; Health Status Indicators; Heart Failure; Humans; Leukocytes; Male; Middle Aged; Natriuretic Peptide, Brain; Nitric Oxide Synthase; Peptide Fragments; Reactive Oxygen Species; Severity of Illness Index; Stroke Volume; Treatment Outcome; Ventricular Function, Left

2011
The association of dimethylarginine dimethylaminohydrolase 1 gene polymorphism with type 2 diabetes: a cohort study.
    Cardiovascular diabetology, 2011, Feb-09, Volume: 10

    Topics: Aged; Amidohydrolases; Analysis of Variance; Arginine; Biomarkers; Blood Glucose; Cardiovascular Diseases; Case-Control Studies; Chi-Square Distribution; Chromatography, High Pressure Liquid; Cohort Studies; Coronary Angiography; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; Humans; Insulin; Insulin Resistance; Kaplan-Meier Estimate; Linear Models; Linkage Disequilibrium; Logistic Models; Male; Middle Aged; Odds Ratio; Phenotype; Polymorphism, Genetic; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Taiwan

2011
Simultaneous gas chromatography-tandem mass spectrometry quantification of symmetric and asymmetric dimethylarginine in human urine.
    Analytical biochemistry, 2011, Jun-01, Volume: 413, Issue:1

    Topics: Adult; Arginine; Gas Chromatography-Mass Spectrometry; Humans; Stereoisomerism; Tandem Mass Spectrometry

2011
Regional differences in hypertensive cardiovascular remodeling between fishing and farming communities in Japan.
    American journal of hypertension, 2011, Volume: 24, Issue:4

    Topics: Aged; Agriculture; Arginine; Carotid Arteries; Cross-Sectional Studies; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Female; Fisheries; Heart Ventricles; Humans; Hypertension; Japan; Male; Middle Aged; Ultrasonography

2011
Inflammation and reduced endothelial function in the course of severe acute heart failure.
    Translational research : the journal of laboratory and clinical medicine, 2011, Volume: 157, Issue:3

    Topics: Acute Disease; Aged; Aged, 80 and over; Arginine; Biomarkers; Case-Control Studies; Endothelium, Vascular; Female; Heart Failure; Humans; Inflammation; Inflammation Mediators; Intercellular Adhesion Molecule-1; Interleukin-6; Interleukin-8; Male; Middle Aged; Prospective Studies; Shock, Cardiogenic; Vascular Cell Adhesion Molecule-1; Vasodilation

2011
Serum asymmetric dimethylarginine levels in diabetic patients with neuropathy.
    Diabetes research and clinical practice, 2011, Volume: 92, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Diabetic Neuropathies; Electrophysiology; Female; Humans; Male; Middle Aged

2011
NO problem: arterial and venous endothelial function and erectile dysfunction.
    European urology, 2011, Volume: 59, Issue:6

    Topics: Arginine; Arteries; Biomarkers; Blood Flow Velocity; Cardiovascular Diseases; Endothelium, Vascular; Humans; Impotence, Vasculogenic; Male; Nitric Oxide; Penile Erection; Penis; Predictive Value of Tests; Regional Blood Flow; Risk Assessment; Risk Factors; Severity of Illness Index; Ultrasonography, Doppler, Color; Up-Regulation; Veins

2011
Asymmetric dimethylarginine and vascular indices of atherosclerosis in patients after coarctation of aorta repair.
    International journal of cardiology, 2012, Jul-26, Volume: 158, Issue:3

    Topics: Adult; Aortic Coarctation; Arginine; Atherosclerosis; Biomarkers; Blood Flow Velocity; C-Reactive Protein; Cardiac Surgical Procedures; Carotid Intima-Media Thickness; Female; Humans; Male; Nitrates; Nitrites; Postoperative Complications; Pulsatile Flow; Vascular Stiffness; Vasodilation

2012
Relationship of asymmetric dimethylarginine with penile Doppler ultrasound parameters in men with vasculogenic erectile dysfunction.
    European urology, 2011, Volume: 59, Issue:6

    Topics: Adult; Aged; Analysis of Variance; Arginine; Arteries; Biomarkers; Blood Flow Velocity; Cardiovascular Diseases; Case-Control Studies; Greece; Humans; Impotence, Vasculogenic; Male; Middle Aged; Penile Erection; Penis; Predictive Value of Tests; Regional Blood Flow; Regression Analysis; Retrospective Studies; Risk Assessment; Risk Factors; ROC Curve; Severity of Illness Index; Ultrasonography, Doppler, Color; Up-Regulation; Veins

2011
[The correlation of asymmetrical dimethylarginine level and oxidative stress to the onset of Alzheimer's disease].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2010, Volume: 45, Issue:8

    Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Arginine; Female; Humans; Male; Malondialdehyde; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Peptide Fragments; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine

2010
Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine.
    The journal of headache and pain, 2011, Volume: 12, Issue:2

    Topics: Adolescent; Adult; Arginine; Biomarkers; Cerebral Arteries; Endothelial Cells; Female; Humans; Male; Middle Aged; Migraine Disorders; Nitric Oxide; Oxidative Stress; Up-Regulation; Young Adult

2011
High concentrations of asymmetric dimethylarginine are associated with ST-segment resolution failure after reperfusion for acute myocardial infarction.
    Clinical chemistry and laboratory medicine, 2011, Volume: 49, Issue:5

    Topics: Angioplasty; Arginine; Biomarkers; Blood Circulation; Electrocardiography; Female; Humans; Lipid Metabolism; Male; Microvessels; Middle Aged; Myocardial Infarction; Reperfusion; Risk Factors

2011
Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsis.
    PloS one, 2011, Feb-18, Volume: 6, Issue:2

    Topics: Adult; Aged; Arginine; Biological Availability; Case-Control Studies; Endothelium, Vascular; Female; Humans; Longitudinal Studies; Male; Middle Aged; Multiple Organ Failure; Nitric Oxide; Sepsis; Severity of Illness Index

2011
Blood pressure and not uraemia is the major determinant of arterial stiffness and endothelial dysfunction in patients with chronic kidney disease and minimal co-morbidity.
    Atherosclerosis, 2011, Volume: 216, Issue:1

    Topics: Adult; Analysis of Variance; Arginine; Biomarkers; Blood Pressure; Brachial Artery; C-Reactive Protein; Carotid Arteries; Case-Control Studies; Chronic Disease; Comorbidity; Compliance; Cross-Sectional Studies; Disease Progression; Endothelin-1; Endothelium, Vascular; Female; Femoral Artery; Glomerular Filtration Rate; Humans; Isoprostanes; Kidney; Kidney Diseases; Linear Models; Male; Middle Aged; Peripheral Arterial Disease; Prospective Studies; Pulsatile Flow; Risk Assessment; Risk Factors; Scotland; Uremia; Vasodilation

2011
cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.
    Circulation, 2011, Mar-22, Volume: 123, Issue:11

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amidohydrolases; Apoptosis; Arginine; Cell Proliferation; Cell Survival; Cells, Cultured; Cyclic GMP; Cytokines; Endothelial Cells; Hemodynamics; Humans; Hypertension, Pulmonary; Naphthyridines; Nitric Oxide; Phosphodiesterase Inhibitors; Promoter Regions, Genetic; Pulmonary Gas Exchange

2011
Targeting dimethylarginine dimethylaminohydrolases in pulmonary arterial hypertension: a new approach to improve vascular dysfunction?
    Circulation, 2011, Mar-22, Volume: 123, Issue:11

    Topics: Amidohydrolases; Arginine; Humans; Hypertension, Pulmonary; Naphthyridines; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase Inhibitors

2011
Effects of coronary revascularization with or without cardiopulmonary bypass on plasma levels of asymmetric dimethylarginine.
    Coronary artery disease, 2011, Volume: 22, Issue:4

    Topics: Aged; Arginine; Biomarkers; Cardiopulmonary Bypass; Chromatography, High Pressure Liquid; Coronary Artery Bypass; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Reperfusion Injury; Tandem Mass Spectrometry

2011
Relationships between serum levels of thyroid hormones and serum concentrations of asymmetric dimethylarginine (ADMA) and N-terminal-pro-B-type natriuretic peptide (NT-proBNP) in patients with Graves' disease.
    Endocrine, 2011, Volume: 39, Issue:3

    Topics: Adult; Arginine; Biomarkers; Blood Pressure; Cardiovascular Diseases; Cross-Sectional Studies; Endothelium, Vascular; Female; Graves Disease; Heart Rate; Hospitals, University; Humans; Immunoglobulins, Thyroid-Stimulating; Male; Natriuretic Peptide, Brain; Peptide Fragments; Risk Factors; Thyroid Hormones; Thyroxine; Triiodothyronine

2011
Exercise-induced alterations of retinal vessel diameters and cardiovascular risk reduction in obesity.
    Atherosclerosis, 2011, Volume: 216, Issue:2

    Topics: Adult; Arginine; Athletes; Cardiovascular Diseases; Enzyme-Linked Immunosorbent Assay; Exercise; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Nitric Oxide; Obesity; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; Surveys and Questionnaires

2011
Arginine/asymmetric dimethylarginine ratio and cardiovascular risk factors in patients with predialytic chronic kidney disease.
    Clinical biochemistry, 2011, Volume: 44, Issue:8-9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Cardiovascular Diseases; Female; Glomerular Filtration Rate; Humans; Kidney Failure, Chronic; Male; Middle Aged; Risk Factors; Young Adult

2011
Elevated concentration of asymmetric dimethylarginine (ADMA) in individuals with metabolic syndrome.
    Nitric oxide : biology and chemistry, 2011, May-31, Volume: 24, Issue:4

    Topics: Arginine; Body Mass Index; Case-Control Studies; Chile; Cholesterol, LDL; Female; Humans; Insulin Resistance; Lipid Peroxidation; Male; Malondialdehyde; Metabolic Syndrome; Middle Aged; Nitric Oxide Synthase; Oxidative Stress; Plasminogen Activator Inhibitor 1; Vascular Cell Adhesion Molecule-1; Waist Circumference

2011
Could ADMA levels in young adults born preterm predict an early endothelial dysfunction?
    International journal of cardiology, 2012, Sep-06, Volume: 159, Issue:3

    Topics: Adolescent; Adult; Arginine; Early Diagnosis; Endothelium, Vascular; Female; Gestational Age; Humans; Infant, Extremely Low Birth Weight; Infant, Low Birth Weight; Infant, Newborn; Male; Predictive Value of Tests; Premature Birth; Vascular Diseases; Young Adult

2012
Increased plasma level of asymmetric dimethylarginine in hypertensive rats facilitates platelet aggregation: role of plasma tissue factor.
    Canadian journal of physiology and pharmacology, 2011, Volume: 89, Issue:3

    Topics: Animals; Arginine; Hypertension; Male; Platelet Aggregation; Random Allocation; Rats; Rats, Inbred WKY; Thromboplastin; Up-Regulation

2011
Asymmetric dimethylarginine impairs fibrinolytic activity in human umbilical vein endothelial cells via p38 MAPK and NF-κB pathways.
    Thrombosis research, 2011, Volume: 128, Issue:1

    Topics: Arginine; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; MAP Kinase Signaling System; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Plasminogen Activator Inhibitor 1; RNA, Messenger; Signal Transduction; Tissue Plasminogen Activator; Umbilical Veins

2011
Asymmetric dimethylarginine levels in Buerger's disease.
    Annals of vascular surgery, 2011, Volume: 25, Issue:4

    Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Chi-Square Distribution; Female; Humans; Male; Middle Aged; Peripheral Arterial Disease; Predictive Value of Tests; Prognosis; Risk Assessment; Risk Factors; Severity of Illness Index; Smoking; Thromboangiitis Obliterans; Turkey; Up-Regulation; Young Adult

2011
Contribution of endogenous inhibitor of nitric oxide synthase to hepatic mitochondrial dysfunction in streptozotocin-induced diabetic rats.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2011, Volume: 27, Issue:3-4

    Topics: Adenosine Triphosphate; Animals; Arginine; Cell Line, Tumor; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Hepatocytes; Ion Channels; Liver; Male; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria, Liver; Mitochondrial Proteins; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Superoxide Dismutase; Transcription Factors; Uncoupling Protein 2

2011
The levels of nitric oxide and asymmetric dimethylarginine in the rat endometriosis model.
    The journal of obstetrics and gynaecology research, 2011, Volume: 37, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Disease Models, Animal; Endometriosis; Female; Nitric Oxide; Peritoneal Diseases; Random Allocation; Rats; Rats, Sprague-Dawley

2011
Methionine-induced homocysteinemia impairs endothelial function in hypertensives: the role of asymmetrical dimethylarginine and antioxidant vitamins.
    American journal of hypertension, 2011, Volume: 24, Issue:8

    Topics: Adult; Antioxidants; Arginine; Ascorbic Acid; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Male; Methionine; Middle Aged; Vasodilation; Vitamin E

2011
Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.
    Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:7

    Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Cardiovascular Diseases; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Female; Genotype; Hypertension; Infusion Pumps, Implantable; Male; Mice; Mice, 129 Strain; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phenotype; Risk Factors; RNA Interference; Substrate Specificity; Time Factors; Transfection

2011
Asymmetric dimethylarginine level in hyperglycemic gestation.
    Endocrine, 2011, Volume: 40, Issue:2

    Topics: Adult; Arginine; Blood Glucose; Body Mass Index; Case-Control Studies; Chromatography, High Pressure Liquid; Diabetes, Gestational; Early Diagnosis; Female; Glucose Intolerance; Glucose Tolerance Test; Humans; Hyperglycemia; Insulin; Insulin Resistance; Pregnancy; Pregnancy Trimester, Third; Prospective Studies; Reproducibility of Results; Spectrometry, Fluorescence

2011
Lipid-apheresis improves microcirculation of the upper limbs.
    Journal of clinical apheresis, 2011, Volume: 26, Issue:4

    Topics: Adult; Aged; Arginine; Atrial Natriuretic Factor; Blood Component Removal; Blood Flow Velocity; Endothelin-1; Epinephrine; Erythrocyte Aggregation; Female; Fibrinogen; Hand; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Laser-Doppler Flowmetry; Lipids; Male; Microcirculation; Microscopic Angioscopy; Middle Aged; Norepinephrine; Photoplethysmography

2011
Protective effect of neferine on endothelial cell nitric oxide production induced by lysophosphatidylcholine: the role of the DDAH-ADMA pathway.
    Canadian journal of physiology and pharmacology, 2011, Volume: 89, Issue:4

    Topics: Aldehydes; Amidohydrolases; Antioxidants; Arginine; Benzylisoquinolines; Cells, Cultured; Endothelial Cells; Humans; Lysophosphatidylcholines; Nitric Oxide; Reactive Oxygen Species; Umbilical Veins

2011
[Alterations in reactive oxygen species and dimethylarginine dimethylaminohydrolase-asymmetric dimethyl-arginine system in the process of endothelial cell senescence induced by high glucose].
    Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2011, Volume: 23, Issue:5

    Topics: Amidohydrolases; Arginine; Cells, Cultured; Cellular Senescence; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Nitric Oxide Synthase; Oxidative Stress; Reactive Oxygen Species

2011
Asymmetric dimethylarginine and coronary artery calcium scores are increased in patients infected with human immunodeficiency virus.
    Atherosclerosis, 2011, Volume: 217, Issue:2

    Topics: Adult; Arginine; Biomarkers; Calcinosis; California; Case-Control Studies; Chi-Square Distribution; Coronary Angiography; Coronary Artery Disease; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Risk Assessment; Risk Factors; RNA, Viral; Tomography, X-Ray Computed; Up-Regulation

2011
Left ventricular hypertrophy is associated with inflammation in sodium loaded subtotal nephrectomized rats.
    Biomedical research (Tokyo, Japan), 2011, Volume: 32, Issue:2

    Topics: Animals; Arginine; Creatinine; Disease Models, Animal; Fibrosis; Hypertension; Hypertrophy, Left Ventricular; Inflammation; Interleukin-6; Kidney Failure, Chronic; Male; Nephrectomy; Parathyroid Hormone; Phosphates; Rats; Rats, Wistar; Risk Factors; Sclerosis; Sodium Chloride

2011
Serum asymmetric dimethylarginine and nitric oxide levels in obese postmenopausal women.
    Journal of clinical laboratory analysis, 2011, Volume: 25, Issue:3

    Topics: Adiponectin; Aged; Aged, 80 and over; Anthropometry; Arginine; Body Mass Index; Female; Ghrelin; Humans; Leptin; Middle Aged; Nitrates; Nitric Oxide; Obesity; Postmenopause

2011
In patients with aortic stenosis increased flow-mediated dilation is independently associated with higher peak jet velocity and lower asymmetric dimethylarginine levels.
    American heart journal, 2011, Volume: 161, Issue:5

    Topics: Aged; Aortic Valve Stenosis; Arginine; Blood Flow Velocity; Blood Pressure; Brachial Artery; Dilatation, Pathologic; Echocardiography; Endothelium, Vascular; Female; Humans; Male; Nitric Oxide Synthase; Risk Factors; Severity of Illness Index; Stroke Volume; Ultrasonography, Doppler

2011
Active site mutant dimethylarginine dimethylaminohydrolase 1 expression confers an intermediate tumour phenotype in C6 gliomas.
    The Journal of pathology, 2011, Volume: 225, Issue:3

    Topics: Amidohydrolases; Animals; Arginine; Catalytic Domain; Female; Glioma; Magnetic Resonance Imaging; Mice; Mice, Nude; Microscopy, Fluorescence; Mutation; Neoplasm Transplantation; Neovascularization, Pathologic; Phenotype; Rats; Transplantation, Heterologous; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A

2011
Asymmetric dimethylarginine concentration and recurrence of atrial tachyarrythmias after catheter ablation in patients with persistent atrial fibrillation.
    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2011, Volume: 32, Issue:2

    Topics: Arginine; Atrial Fibrillation; Biomarkers; Body Surface Potential Mapping; Catheter Ablation; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Recurrence; Risk Assessment; Survival Rate; Time Factors; Treatment Outcome

2011
Chronic kidney disease: the silent enemy?
    Anesthesia and analgesia, 2011, Volume: 112, Issue:6

    Topics: Anesthesiology; Arginine; Creatinine; Glomerular Filtration Rate; Humans; Kidney; Kidney Failure, Chronic; Kidney Transplantation; Renal Dialysis; Risk; Treatment Outcome

2011
Cellular hypomethylation is associated with impaired nitric oxide production by cultured human endothelial cells.
    Amino acids, 2012, Volume: 42, Issue:5

    Topics: Arginine; Cells, Cultured; Endothelial Cells; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Hyperhomocysteinemia; Methylation; Nitric Oxide; Nitric Oxide Synthase Type III; S-Adenosylhomocysteine; Vascular Diseases

2012
Vascular function in the diagnostic categories of polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2011, Volume: 26, Issue:8

    Topics: Adult; Arginine; C-Reactive Protein; Cardiovascular Diseases; Cross-Sectional Studies; Endothelium, Vascular; Female; Humans; Insulin Resistance; Overweight; Phenotype; Plasminogen Activator Inhibitor 1; Polycystic Ovary Syndrome; Vascular Resistance

2011
The effect of pharmacological treatment on ADMA in patients with heart failure.
    Frontiers in bioscience (Elite edition), 2011, 06-01, Volume: 3, Issue:4

    Topics: Aged; Arginine; Female; Heart Failure; Humans; Male; Middle Aged

2011
Coronary flow reserve and asymmetric dimethylarginine levels: new measurements for identifying subclinical atherosclerosis in patients with psoriatic arthritis.
    The Journal of rheumatology, 2011, Volume: 38, Issue:8

    Topics: Adult; Aged; Arginine; Arthritis, Psoriatic; Atherosclerosis; Biomarkers; Carotid Artery, Common; Coronary Circulation; Dipyridamole; Echocardiography, Stress; Enzyme Inhibitors; Female; Humans; Middle Aged; Tunica Intima; Tunica Media

2011
Relationship between plasma coenzyme Q10, asymmetric dimethylarginine and arterial stiffness in patients with phenotypic or genotypic familial hypercholesterolemia on long-term statin therapy.
    Atherosclerosis, 2011, Volume: 218, Issue:1

    Topics: Aged; Arginine; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Genotype; Heterozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Male; Middle Aged; Mutation; Receptors, LDL; Ubiquinone; Vascular Stiffness

2011
Asymmetric dimethylarginine and clinical outcomes in chronic kidney disease.
    Clinical journal of the American Society of Nephrology : CJASN, 2011, Volume: 6, Issue:7

    Topics: Aged; Aged, 80 and over; Albuminuria; Arginine; Biomarkers; Chi-Square Distribution; Chromatography, High Pressure Liquid; Disease-Free Survival; Female; Glomerular Filtration Rate; Humans; Kaplan-Meier Estimate; Kidney Diseases; Male; Middle Aged; Myocardial Infarction; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Stroke; Taiwan; Time Factors

2011
Inflammation and asymmetric dimethylarginine for predicting death and cardiovascular events in ESRD patients.
    Clinical journal of the American Society of Nephrology : CJASN, 2011, Volume: 6, Issue:7

    Topics: Adult; Aged; Analysis of Variance; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Chi-Square Distribution; Cohort Studies; Female; Humans; Inflammation; Inflammation Mediators; Interleukin-6; Italy; Kidney Failure, Chronic; Male; Middle Aged; Prognosis; Proportional Hazards Models; Renal Dialysis; Risk Assessment; Risk Factors; Time Factors

2011
The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis.
    Science translational medicine, 2011, Jun-15, Volume: 3, Issue:87

    Topics: Amidohydrolases; Animals; Antibiotics, Antineoplastic; Apoptosis; Arginine; Bleomycin; Cell Line; Cell Proliferation; Collagen; Female; Fibroblasts; Fibrosis; Humans; Idiopathic Pulmonary Fibrosis; Isoenzymes; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Nitric Oxide Synthase Type II; Random Allocation

2011
DDAH says NO to ADMA.
    Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:7

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Endothelial Cells; Humans; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Risk Factors; Substrate Specificity

2011
Vascular endothelial function assessed by a noninvasive ultrasound method and serum asymmetric dimethylarginine concentrations in mild-to-moderate plaque-type psoriatic patients.
    Clinical biochemistry, 2011, Volume: 44, Issue:13

    Topics: Acute-Phase Proteins; Adult; Arginine; C-Reactive Protein; Case-Control Studies; Endothelium, Vascular; Female; Fibrinogen; Humans; Male; Psoriasis; Severity of Illness Index; Ultrasonography; Vasodilation

2011
Serum levels of arginase I are associated with left ventricular function after myocardial infarction.
    Clinical biochemistry, 2011, Volume: 44, Issue:13

    Topics: Arginase; Arginine; Case-Control Studies; Humans; Myocardial Infarction; Stroke Volume; Ventricular Function, Left

2011
Chronic renal failure alters endothelial function in cerebral circulation in mice.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 301, Issue:3

    Topics: Analysis of Variance; Animals; Apolipoproteins E; Arginine; Arterioles; Blotting, Western; Caveolin 1; Cerebrovascular Circulation; Cerebrovascular Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Inflammation Mediators; Kidney Failure, Chronic; Mice; Mice, Inbred C57BL; Mice, Knockout; Nephrectomy; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Pia Mater; PPAR gamma; rho-Associated Kinases; Vascular Cell Adhesion Molecule-1; Vasodilation; Vasodilator Agents

2011
Quantitation of L-arginine and asymmetric dimethylarginine in human plasma by LC-selective ion mode-MS for Type 2 diabetes mellitus study.
    Chemical & pharmaceutical bulletin, 2011, Volume: 59, Issue:7

    Topics: Adult; Aged; Arginine; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Female; Humans; Male; Mass Spectrometry; Middle Aged

2011
Age-related modification of antioxidant enzyme activities in relation to cardiovascular risk factors.
    European journal of clinical investigation, 2012, Volume: 42, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Apolipoproteins A; Arginine; Cardiovascular Diseases; Catalase; Enzyme-Linked Immunosorbent Assay; Female; Fetuins; Glutathione Peroxidase; Humans; Lipid Peroxidation; Lipoproteins; Lipoproteins, LDL; Male; Oxidation-Reduction; Oxidative Stress; Risk Factors; Statistics as Topic; Superoxide Dismutase

2012
The biological effect of pharmacological treatment on dimethylaminohydrolases (DDAH-1) and cationic amino acid transporter-1 (CAT-1) expression in patients with acute congestive heart failure.
    Microvascular research, 2011, Volume: 82, Issue:3

    Topics: Acute Disease; Aged; Amidohydrolases; Arginine; Cardiovascular Agents; Cationic Amino Acid Transporter 1; Chromatography, High Pressure Liquid; Echocardiography, Doppler; Female; Heart Failure; Humans; Italy; Male; Middle Aged; Stroke Volume; Treatment Outcome; Ventricular Function, Left

2011
Elevated plasma asymmetric dimethylarginine level in acute myocardial infarction patients as a predictor of poor prognosis and angiographic impaired reperfusion.
    Atherosclerosis, 2011, Volume: 219, Issue:1

    Topics: Aged; Arginine; Coronary Angiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Prognosis

2011
Asymmetric dimethylarginine (ADMA) levels display a morning peak in patients with acute myocardial infarction.
    Disease markers, 2011, Volume: 30, Issue:5

    Topics: Aged; Arginine; Biomarkers; Blood Pressure; Body Mass Index; Circadian Rhythm; Cross-Sectional Studies; Female; Humans; Linear Models; Male; Middle Aged; Myocardial Infarction; Nitric Oxide Synthase; Nitrogen Oxides; Platelet Activation; Time Factors

2011
Endogenous hydrogen sulfide is involved in asymmetric dimethylarginine-induced protection against neurotoxicity of 1-methyl-4-phenyl-pyridinium ion.
    Neurochemical research, 2011, Volume: 36, Issue:11

    Topics: 1-Methyl-4-phenylpyridinium; Aminooxyacetic Acid; Animals; Antioxidants; Arginine; Cyclin D1; Cystathionine beta-Synthase; Cytochromes c; Down-Regulation; Hydrogen Sulfide; Membrane Potential, Mitochondrial; Neuroprotective Agents; PC12 Cells; Rats; Reactive Oxygen Species

2011
Asymmetric dimethylarginine predicts appropriate implantable cardioverter-defibrillator intervention in patients with left ventricular dysfunction.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2011, Volume: 13, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Defibrillators, Implantable; Follow-Up Studies; Humans; Male; Middle Aged; Nitric Oxide; Predictive Value of Tests; Prospective Studies; Retrospective Studies; Risk Factors; Tachycardia, Ventricular; Treatment Outcome; Ventricular Dysfunction, Left

2011
Effect of silibinin on endothelial dysfunction and ADMA levels in obese diabetic mice.
    Cardiovascular diabetology, 2011, Jul-14, Volume: 10

    Topics: Acetylcholine; Animals; Antioxidants; Aorta; Arginine; Diabetes Mellitus; Disease Models, Animal; Endothelium, Vascular; Insulin Resistance; Liver; Male; Mice; Mice, Obese; Nitroprusside; Obesity; Phenylephrine; Silybin; Silymarin; Vasoconstrictor Agents; Vasodilator Agents

2011
Serum asymmetric dimethylarginine, nitrate, vitamin B(12), and homocysteine levels in individuals with pulmonary embolism.
    Mediators of inflammation, 2011, Volume: 2011

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Female; Homocysteine; Humans; Male; Middle Aged; Nitrates; Oxygen; Partial Pressure; Predictive Value of Tests; Prognosis; Pulmonary Embolism; Pulmonary Wedge Pressure; Risk Factors; Vitamin B 12

2011
Symmetric dimethylarginine is a marker of detrimental outcome in the acute phase after ischaemic stroke: role of renal function.
    Clinical science (London, England : 1979), 2012, Volume: 122, Issue:3

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Brain Ischemia; Chromatography, Liquid; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Kidney; Male; Middle Aged; Multivariate Analysis; Outcome Assessment, Health Care; Prognosis; Proportional Hazards Models; Stroke; Tandem Mass Spectrometry; Time Factors

2012
AADMA as a marker of endothelial dysfunction in prediabetic women.
    Acta medica Indonesiana, 2011, Volume: 43, Issue:2

    Topics: Adult; Arginine; Biomarkers; Body Mass Index; Brachial Artery; Chromatography, High Pressure Liquid; Confidence Intervals; Cross-Sectional Studies; Endothelium, Vascular; Female; Glycated Hemoglobin; Humans; Linear Models; Middle Aged; Multivariate Analysis; Prediabetic State; Time Factors; Women's Health

2011
Plasma asymmetric dimethylarginine predicts death and major adverse cardiovascular events in individuals referred for coronary angiography.
    International journal of cardiology, 2011, Dec-01, Volume: 153, Issue:2

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Cardiovascular Diseases; Coronary Angiography; Death; Female; Follow-Up Studies; Humans; Male; Middle Aged; Predictive Value of Tests; Referral and Consultation; Risk Factors

2011
Symmetric dimethylarginine as a proinflammatory agent in chronic kidney disease.
    Clinical journal of the American Society of Nephrology : CJASN, 2011, Volume: 6, Issue:10

    Topics: Acetylcysteine; Aged; Aged, 80 and over; Arginine; Belgium; Biomarkers; Case-Control Studies; Cell Line; Chronic Disease; Cross-Sectional Studies; Female; Humans; Inflammation Mediators; Interleukin-6; Kidney Diseases; Linear Models; Male; Middle Aged; Monocytes; NF-kappa B; Predictive Value of Tests; ROC Curve; Tumor Necrosis Factor-alpha

2011
Asymmetric dimethylarginine confers the communication between endothelial and smooth muscle cells and leads to VSMC migration through p38 and ERK1/2 signaling cascade.
    FEBS letters, 2011, Sep-02, Volume: 585, Issue:17

    Topics: Animals; Arginine; Blotting, Western; Cell Movement; Cells, Cultured; Endothelial Cells; Humans; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Rats; Signal Transduction

2011
Simultaneous determination of L-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in the plasma of rodents with LC-MS/MS.
    Arzneimittel-Forschung, 2011, Volume: 61, Issue:6

    Topics: Animals; Arginine; Calibration; Chromatography, High Pressure Liquid; Indicators and Reagents; Male; Mass Spectrometry; Mice; Mice, Inbred ICR; Quality Control; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry

2011
Homocysteine and asymmetric dimethylarginine in relation to B vitamins in elderly people.
    Wiener klinische Wochenschrift, 2011, Volume: 123, Issue:15-16

    Topics: Aged; Aged, 80 and over; Arginine; Biological Availability; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Hypercholesterolemia; Male; Nitric Oxide; Nitric Oxide Synthase; Statistics as Topic; Vasodilation; Vitamin B 12; Vitamin B 6

2011
Unilateral nephrectomy causes an abrupt increase in inflammatory mediators and a simultaneous decrease in plasma ADMA: a study in living kidney donors.
    American journal of physiology. Renal physiology, 2011, Volume: 301, Issue:5

    Topics: Arginine; C-Reactive Protein; Creatinine; Female; Humans; Inflammation Mediators; Interleukin-6; Kidney Function Tests; Living Donors; Longitudinal Studies; Male; Middle Aged; Nephrectomy; Prospective Studies; Tissue and Organ Harvesting; Urea

2011
Plasma asymmetric dimethylarginine (ADMA) concentrations in patients with first and multiple episode schizophrenia.
    Psychiatry research, 2011, Dec-30, Volume: 190, Issue:2-3

    Topics: Adult; Arginine; Chromatography, High Pressure Liquid; Humans; Male; Psychiatric Status Rating Scales; Schizophrenia; Statistics, Nonparametric; Young Adult

2011
Day-night variations in endothelial dysfunction markers and haemostatic factors in sleep apnoea.
    The European respiratory journal, 2012, Volume: 39, Issue:4

    Topics: Adult; Arginine; Blood Coagulation; Body Mass Index; Cardiovascular Diseases; CD40 Ligand; Circadian Rhythm; Endothelium, Vascular; Erythrocyte Count; Factor VII; Humans; Leukocyte Count; Middle Aged; Plasminogen Activator Inhibitor 1; Platelet Count; Sleep Apnea Syndromes; von Willebrand Factor; Waist Circumference

2012
Changes in the arginine methylation of organ proteins during the development of diabetes mellitus.
    Diabetes research and clinical practice, 2011, Volume: 94, Issue:1

    Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Diabetes Mellitus; Male; Methylation; Mice; Nitric Oxide; Nitric Oxide Synthase

2011
Role of asymmetric dimethylarginine in acute lung injury induced by cerebral ischemia/reperfusion injury in rats.
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2011, Volume: 31, Issue:8

    Topics: Acute Lung Injury; Animals; Arginine; Brain Ischemia; Male; Myosin-Light-Chain Kinase; Nitric Oxide Synthase; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Up-Regulation

2011
Actin cytoskeleton modulates ADMA-induced NF-kappaB nuclear translocation and ICAM-1 expression in endothelial cells.
    Medical science monitor : international medical journal of experimental and clinical research, 2011, Volume: 17, Issue:9

    Topics: Actin Cytoskeleton; Arginine; Cell Nucleus; Cytochalasin D; Depsipeptides; DNA; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; NF-kappa B; Protein Binding; Protein Transport; Stress Fibers; Transcription Factor RelA

2011
Increased asymmetric dimethylarginine and enhanced inflammation are associated with impaired vascular reactivity in women with endometriosis.
    Atherosclerosis, 2011, Volume: 219, Issue:2

    Topics: Adult; Arginine; Biomarkers; Brachial Artery; C-Reactive Protein; Case-Control Studies; Endometriosis; Female; Humans; Inflammation Mediators; Interleukin-6; Japan; Least-Squares Analysis; Lipids; Regression Analysis; Serum Amyloid A Protein; Ultrasonography, Doppler; Up-Regulation; Vasodilation

2011
Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizing factor in small arteries from rat.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 339, Issue:3

    Topics: Animals; Anthracenes; Apamin; Arginine; Biological Factors; Drug Evaluation, Preclinical; Human Umbilical Vein Endothelial Cells; Indoles; Male; Mesenteric Arteries; Nitric Oxide; Nitric Oxide Synthase; Oximes; Potassium Channels, Calcium-Activated; Propane; Pyrazoles; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents

2011
Ascorbic acid or L-arginine improves cutaneous microvascular function in chronic kidney disease.
    Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 111, Issue:6

    Topics: Adult; Arginine; Ascorbic Acid; Case-Control Studies; Female; Hot Temperature; Humans; Male; Microcirculation; Microdialysis; Middle Aged; Nitric Oxide; Oxidative Stress; Renal Insufficiency, Chronic; Skin; Vasodilation

2011
The effect of calcineurin inhibitors on endothelial and platelet function in renal transplant patients.
    Clinical nephrology, 2011, Volume: 76, Issue:3

    Topics: Adult; Arginine; Calcineurin Inhibitors; Cyclosporine; Endothelium, Vascular; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Mycophenolic Acid; Nitric Oxide Synthase; P-Selectin; Platelet Activation; Platelet Aggregation; Tacrolimus

2011
Determination of asymmetric dimethyl arginine in human serum by liquid chromatography-tandem mass spectrometry: clinical application in hypertensive subjects.
    Clinical chemistry and laboratory medicine, 2011, Sep-06, Volume: 49, Issue:12

    Topics: Adolescent; Adult; Arginine; Chromatography, High Pressure Liquid; Female; Humans; Hydrophobic and Hydrophilic Interactions; Hypertension; Male; Middle Aged; Tandem Mass Spectrometry; Young Adult

2011
Late effects of renal transplantation on endothelial functions and cardiac morphology.
    Transplantation proceedings, 2011, Volume: 43, Issue:7

    Topics: Adult; Arginine; C-Reactive Protein; Case-Control Studies; Cyclosporine; Endothelium, Vascular; Female; Heart; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Tacrolimus; Tunica Intima

2011
Synergistic adverse prognostic effects of asymmetric dimethylarginine and endothelial progenitor-related cells deficiency after elective coronary angioplasty.
    International journal of cardiology, 2011, Nov-03, Volume: 152, Issue:3

    Topics: Aged; Angioplasty, Balloon, Coronary; Arginine; Cell Count; Elective Surgical Procedures; Endothelial Cells; Follow-Up Studies; Humans; Male; Middle Aged; Prognosis; Prospective Studies; Risk Factors; Stem Cells

2011
Pseudomonas aeruginosa is associated with increased lung cytokines and asymmetric dimethylarginine compared with methicillin-resistant Staphylococcus aureus.
    Shock (Augusta, Ga.), 2011, Volume: 36, Issue:5

    Topics: Animals; Arginine; Cytokines; Female; Interleukin-1; Interleukin-13; Lung; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred C57BL; Pseudomonas aeruginosa; Sheep

2011
Asymmetric dimethylarginine (ADMA): is really a biomarker for cardiovascular prognosis?
    International journal of cardiology, 2011, Dec-01, Volume: 153, Issue:2

    Topics: Arginine; Cardiovascular Diseases; Coronary Angiography; Female; Humans; Male; Referral and Consultation

2011
Sympathetic nerve traffic and asymmetric dimethylarginine in chronic kidney disease.
    Clinical journal of the American Society of Nephrology : CJASN, 2011, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Chronic Disease; Cross-Sectional Studies; Disease Progression; Female; Glomerular Filtration Rate; Humans; Hypertrophy, Left Ventricular; Italy; Kidney; Kidney Diseases; Linear Models; Male; Proteinuria; Risk Assessment; Risk Factors; Severity of Illness Index; Sympathetic Fibers, Postganglionic; Ventricular Remodeling

2011
Levels of soluble advanced glycation end product-receptors and other soluble serum markers as indicators of diabetic neuropathy in the foot.
    Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2011, Volume: 59, Issue:8

    Topics: Aged; Arginine; Biomarkers; Diabetes Mellitus, Type 2; Diabetic Foot; Diabetic Neuropathies; Glycated Hemoglobin; Humans; Male; Middle Aged; Nitric Oxide; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Solubility

2011
Detection and quantification of α-keto-δ-(N(G),N(G)-dimethylguanidino)valeric acid: a metabolite of asymmetric dimethylarginine.
    Analytical biochemistry, 2011, Dec-15, Volume: 419, Issue:2

    Topics: Adult; Arginine; Biochemistry; Calibration; Chromatography, High Pressure Liquid; Female; Guanidines; Humans; Keto Acids; Limit of Detection; Male; Mass Spectrometry; Middle Aged

2011
Aliskiren prevents hypertension and reduces asymmetric dimethylarginine in young spontaneously hypertensive rats.
    European journal of pharmacology, 2011, Nov-30, Volume: 670, Issue:2-3

    Topics: Amides; Animals; Antihypertensive Agents; Arginine; Blood Pressure; Dose-Response Relationship, Drug; Fumarates; Gene Expression Regulation, Enzymologic; Hypertension; Kidney Cortex; Male; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Renin

2011
Exercise blood pressure response is related to asymmetric dimethylarginine and osteoprotegerin in hypertension.
    International journal of cardiology, 2011, Nov-17, Volume: 153, Issue:1

    Topics: Adult; Arginine; Biomarkers; Blood Pressure; Exercise; Exercise Test; Humans; Hypertension; Male; Middle Aged; Osteoprotegerin

2011
The transhepatic endotoxin gradient is present despite liver cirrhosis and is attenuated after transjugular portosystemic shunt (TIPS).
    BMC gastroenterology, 2011, Oct-06, Volume: 11

    Topics: Acute-Phase Proteins; Adult; Aged; Arginine; Bacterial Translocation; Carrier Proteins; Cohort Studies; Female; Gram-Negative Bacteria; Humans; Lipopolysaccharides; Liver Circulation; Liver Cirrhosis; Male; Membrane Glycoproteins; Middle Aged; Portasystemic Shunt, Transjugular Intrahepatic

2011
A dietary approach to increase in-stent stenosis and face validity of a rat model for arterial angioplasty and stenting.
    Atherosclerosis, 2011, Volume: 219, Issue:2

    Topics: Angioplasty, Balloon; Animals; Arginine; Biomarkers; Carotid Arteries; Carotid Artery Injuries; Carotid Stenosis; Choline Deficiency; Diet, Atherogenic; Disease Models, Animal; Endothelial Cells; Female; Hyperplasia; Inflammation Mediators; Interleukin-6; Lipids; Male; Platelet Activation; Rats; Rats, Sprague-Dawley; Recurrence; Reproducibility of Results; Stents; Thromboxane B2; Time Factors; Ultrasonography, Doppler, Color

2011
Role of dimethylarginine dimethylaminohydrolase activity in regulation of tissue and plasma concentrations of asymmetric dimethylarginine in an animal model of prolonged critical illness.
    Metabolism: clinical and experimental, 2012, Volume: 61, Issue:4

    Topics: Amidohydrolases; Animals; Arginine; Critical Illness; Kidney; Liver; Male; Multivariate Analysis; Muscle, Skeletal; Myocardium; Rabbits; Regression Analysis

2012
Apelin-13 passes through the ADMA-damaged endothelial barrier and acts on vascular smooth muscle cells.
    Peptides, 2011, Volume: 32, Issue:12

    Topics: Acetophenones; Arginine; Blotting, Western; Capillary Permeability; Cells, Cultured; Coculture Techniques; Dextrans; Fluorescein-5-isothiocyanate; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Intercellular Junctions; Intercellular Signaling Peptides and Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin Light Chains; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Stress Fibers; Time Factors

2011
Levels of asymmetric dimethylarginine throughout normal pregnancy and in pregnancies complicated with preeclampsia or had a small for gestational age baby.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2012, Volume: 25, Issue:8

    Topics: Adult; Arginine; Blood Chemical Analysis; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Fetal Growth Retardation; Humans; Infant, Newborn; Infant, Small for Gestational Age; Male; Osmolar Concentration; Pre-Eclampsia; Pregnancy

2012
Endothelial dysfunction and high cardiovascular risk profile in severe alcoholics improve only partially following a medium-term alcohol withdrawal.
    Alcoholism, clinical and experimental research, 2012, Volume: 36, Issue:2

    Topics: Adult; Age of Onset; Aged; Alcoholism; Arginine; Biomarkers; Blood Pressure; Brachial Artery; Cardiovascular Diseases; Confidence Intervals; Endothelium, Vascular; Female; Heart Rate; Humans; Insulin Resistance; Lipids; Logistic Models; Male; Middle Aged; Odds Ratio; Oxidative Stress; Risk Assessment; Smoking; Vasodilation

2012
Immunosuppressants accelerate microvascular thrombus formation in vivo: role of endothelial cell activation.
    Surgery, 2012, Volume: 151, Issue:1

    Topics: Animals; Arginine; Endothelium, Vascular; Immunohistochemistry; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Microvessels; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; P-Selectin; Reperfusion Injury; Thrombosis; Vascular Cell Adhesion Molecule-1

2012
Reference intervals for plasma L-arginine and the L-arginine:asymmetric dimethylarginine ratio in the Framingham Offspring Cohort.
    The Journal of nutrition, 2011, Volume: 141, Issue:12

    Topics: Aged; Arginine; Chromatography, Liquid; Cross-Sectional Studies; Dietary Supplements; Endothelium-Dependent Relaxing Factors; Female; Glomerular Filtration Rate; Humans; Male; Massachusetts; Middle Aged; Nitric Oxide Synthase; Reference Values; Tandem Mass Spectrometry

2011
Stimulus-specific blockade of nitric oxide-mediated dilatation by asymmetric dimethylarginine (ADMA) and monomethylarginine (L-NMMA) in rat aorta and carotid artery.
    European journal of pharmacology, 2011, Dec-30, Volume: 673, Issue:1-3

    Topics: Animals; Aorta; Arginine; Carotid Arteries; Female; Male; Naphthyridines; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Phenylephrine; Pyrimidines; Rats; Rats, Wistar; Superoxide Dismutase; Vasodilation

2011
The role of asymmetric dimethyl arginine and oxidant/antioxidant system in preeclampsia.
    Fetal and pediatric pathology, 2011, Volume: 30, Issue:6

    Topics: Adult; Antioxidants; Arginine; Case-Control Studies; Citrulline; Female; Fetal Blood; Humans; Lipid Peroxidation; Malondialdehyde; Oxidants; Oxidative Stress; Pre-Eclampsia; Pregnancy; Young Adult

2011
Apocynin attenuates oxidative stress and hypertension in young spontaneously hypertensive rats independent of ADMA/NO pathway.
    Free radical research, 2012, Volume: 46, Issue:1

    Topics: Acetophenones; Animals; Antioxidants; Arginine; Hypertension; Male; NADPH Oxidases; Nitric Oxide; Oxidative Stress; Random Allocation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species

2012
Increased asymmetric dimethylarginine (ADMA) dimethylaminohydrolase (DDAH) activity in childhood hypercholesterolemia type II.
    Amino acids, 2012, Volume: 43, Issue:2

    Topics: Adolescent; Amidohydrolases; Arginine; Case-Control Studies; Child; Female; Humans; Hypercholesterolemia; Male; Statistics, Nonparametric

2012
Favorable effect of short-term lifestyle intervention on human paraoxonase-1 activity and adipokine levels in childhood obesity.
    Journal of the American College of Nutrition, 2011, Volume: 30, Issue:5

    Topics: Adipokines; Adiponectin; Adolescent; Arginine; Aryldialkylphosphatase; Body Mass Index; Child; Diet; E-Selectin; Feeding Behavior; Female; Humans; Leptin; Life Style; Lipids; Male; Motor Activity; Obesity; Risk Factors

2011
Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase.
    Circulation, 2011, Dec-13, Volume: 124, Issue:24

    Topics: Amidohydrolases; Animals; Arginine; Cardiovascular Diseases; Dose-Response Relationship, Drug; Female; HL-60 Cells; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Models, Animal; Neutrophils; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxidase; Signal Transduction; Superoxides

2011
Asymmetric dimethylarginine (ADMA) determines the improvement of hepatic endothelial dysfunction by vitamin E in cirrhotic rats.
    Liver international : official journal of the International Association for the Study of the Liver, 2012, Volume: 32, Issue:1

    Topics: Animals; Antioxidants; Arginine; Drug Synergism; Endothelial Cells; Enzyme Inhibitors; Hemodynamics; Hypertension, Portal; In Vitro Techniques; Lipid Peroxidation; Liver; Liver Cirrhosis, Experimental; Male; Nitric Oxide; Oxidative Stress; Perfusion; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vitamin E

2012
Ethnicity-specific differences in L-arginine status in South African men.
    Journal of human hypertension, 2012, Volume: 26, Issue:12

    Topics: Adult; Aged; Arginine; Black People; Cardiovascular Diseases; Cross-Sectional Studies; Humans; Hypertension; Linear Models; Male; Middle Aged; Multivariate Analysis; Prevalence; Risk Factors; South Africa; White People

2012
Imbalance of arginine and asymmetric dimethylarginine is associated with markers of circulatory failure, organ failure and mortality in shock patients.
    The British journal of nutrition, 2012, Volume: 107, Issue:10

    Topics: Aged; Area Under Curve; Arginine; Biomarkers; Blood Coagulation; Blood Glucose; Carbonates; Creatine Kinase; Female; Humans; Hydrogen-Ion Concentration; Lactic Acid; Male; Middle Aged; Multiple Organ Failure; Nitric Oxide; Nitric Oxide Synthase; Predictive Value of Tests; Prospective Studies; Severity of Illness Index; Shock

2012
Continuous exposure to L-arginine induces oxidative stress and physiological tolerance in cultured human endothelial cells.
    Amino acids, 2012, Volume: 43, Issue:3

    Topics: Arginase; Arginine; Ascorbic Acid; Cells, Cultured; Citrulline; Culture Media; Down-Regulation; Drug Tolerance; Free Radical Scavengers; Gene Expression; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Polyethylene Glycols; Superoxide Dismutase; Superoxides

2012
Asymmetric dimethylarginine may mediate increased heat pain threshold in experimental chronic kidney disease.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012, Volume: 27, Issue:3

    Topics: Animals; Arginine; Enzyme Inhibitors; Hot Temperature; Kidney Failure, Chronic; Male; Nephrectomy; Nitric Oxide Synthase; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley

2012
Endothelial dysfunction of the peripheral vascular bed in the acute phase after ischemic stroke.
    Cerebrovascular diseases (Basel, Switzerland), 2012, Volume: 33, Issue:1

    Topics: Aged; Analysis of Variance; Arginine; Biomarkers; Blood Pressure; Case-Control Studies; Endothelium, Vascular; Female; Fingers; Forearm; Germany; Heart Failure; Humans; Hyperemia; Infarction, Middle Cerebral Artery; Linear Models; Male; Middle Aged; Plethysmography; Severity of Illness Index; Time Factors; Up-Regulation; Vasodilation

2012
Relationships of osteoprotegerin with albuminuria and asymmetric dimethylarginine in essential hypertension: integrating vascular dysfunction.
    Expert opinion on therapeutic targets, 2011, Volume: 15, Issue:12

    Topics: Adult; Albuminuria; Arginine; Blood Pressure; Cross-Sectional Studies; Echocardiography; Endothelium, Vascular; Female; Humans; Hypertension; Male; Middle Aged; Osteoprotegerin

2011
In vivo nitric oxide synthesis, insulin sensitivity, and asymmetric dimethylarginine in obese subjects without and with metabolic syndrome.
    Metabolism: clinical and experimental, 2012, Volume: 61, Issue:5

    Topics: Adult; Arginine; Blood Glucose; Blood Pressure; Cholesterol, HDL; Female; Glucose Tolerance Test; Humans; Insulin Resistance; Male; Metabolic Syndrome; Nitrates; Nitric Oxide; Obesity; Saliva; Triglycerides; Waist Circumference

2012
Asymmetric dimethylarginine, arginine and homoarginine at 11-13 weeks' gestation and preeclampsia: a case-control study.
    Journal of human hypertension, 2013, Volume: 27, Issue:1

    Topics: Adult; Arginine; Case-Control Studies; Female; Gas Chromatography-Mass Spectrometry; Homoarginine; Humans; Nitric Oxide; Pre-Eclampsia; Pregnancy; Regression Analysis

2013
Arginine and asymmetric dimethylarginine in puromycin aminonucleoside-induced chronic kidney disease in the rat.
    American journal of nephrology, 2012, Volume: 35, Issue:1

    Topics: Animals; Aorta; Arginase; Arginine; Creatinine; Dose-Response Relationship, Drug; Kidney Cortex; Kidney Failure, Chronic; Male; Oxidative Stress; Puromycin Aminonucleoside; Rats; Rats, Sprague-Dawley

2012
Elevated asymmetric dimethylarginine in plasma: an early marker for endothelial dysfunction in non-alcoholic fatty liver disease?
    Diabetes research and clinical practice, 2012, Volume: 96, Issue:1

    Topics: Adult; Arginine; Biomarkers; Carotid Artery Diseases; Carotid Intima-Media Thickness; Fatty Liver; Humans; Male; Non-alcoholic Fatty Liver Disease; Young Adult

2012
Endotoxemia exacerbates kidney injury and increases asymmetric dimethylarginine in young bile duct-ligated rats.
    Shock (Augusta, Ga.), 2012, Volume: 37, Issue:4

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acute Kidney Injury; Animals; Arginine; Bile Ducts; Blotting, Western; Chromatography, High Pressure Liquid; Citrulline; Deoxyguanosine; Endotoxemia; Immunohistochemistry; Male; Rats; Rats, Sprague-Dawley

2012
Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence.
    The American journal of pathology, 2012, Volume: 180, Issue:3

    Topics: Animals; Apoptosis; Arginine; Autophagy; Azoles; Cardiovascular Diseases; Cathepsins; Cell Membrane Permeability; Cells, Cultured; Cellular Senescence; Collagen Type I; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Hydrogen Peroxide; Isoindoles; Lysosomes; Mice; Mice, Knockout; Mice, Transgenic; Organoselenium Compounds; Recombinant Proteins; Risk Factors; Sirtuin 1; Stem Cells; Stress, Physiological

2012
The combined ratios of L-arginine and asymmetric and symmetric dimethylarginine as biomarkers in spontaneously hypertensive rats.
    Translational research : the journal of laboratory and clinical medicine, 2012, Volume: 159, Issue:2

    Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Blood Pressure; Hypertension; Male; Models, Animal; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY

2012
Changes of skin temperature of parts of the body and serum asymmetric dimethylarginine (ADMA) in type-2 diabetes mellitus Indian patients.
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2011, Volume: 2011

    Topics: Adult; Arginine; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; India; Infrared Rays; Male; Microcirculation; Middle Aged; Risk; Risk Assessment; Skin Temperature; Temperature; Thermography

2011
Dimethylated L-arginine analogues versus autoantibodies in early rheumatoid arthritis.
    Scandinavian journal of rheumatology, 2012, Volume: 41, Issue:1

    Topics: Adult; Arginine; Arthritis, Rheumatoid; Autoantibodies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Peptides, Cyclic; Rheumatoid Factor

2012
Nitric oxide activity in platelets of dengue haemorrhagic fever patients: the apparent paradoxical role of ADMA and l-NMMA.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 2012, Volume: 106, Issue:3

    Topics: Adult; Arginine; Blood Platelets; Brazil; Enzyme Inhibitors; Female; Humans; Male; Nitric Oxide Synthase; omega-N-Methylarginine; Platelet Aggregation; Severe Dengue; Thrombocytopenia

2012
Inhibition of eNOS phosphorylation mediates endothelial dysfunction in renal failure: new effect of asymmetric dimethylarginine.
    Kidney international, 2012, Volume: 81, Issue:8

    Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide Synthase Type III; Phosphorylation; Recombinant Proteins; Renal Insufficiency, Chronic; Vasodilation

2012
The relationship between L-arginine/ADMA ratio and coronary collateral development in patients with low glomerular filtration rate.
    Cardiology journal, 2012, Volume: 19, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Chi-Square Distribution; Collateral Circulation; Coronary Angiography; Coronary Circulation; Coronary Stenosis; Female; Glomerular Filtration Rate; Humans; Kidney Diseases; Linear Models; Logistic Models; Male; Middle Aged; Multivariate Analysis; Neovascularization, Physiologic; Odds Ratio; Risk Assessment; Risk Factors; Severity of Illness Index; Turkey

2012
Development of an enzyme-linked immunosorbent assay system for the determination of asymmetric dimethylarginine using a specific monoclonal antibody.
    Bioscience, biotechnology, and biochemistry, 2012, Volume: 76, Issue:2

    Topics: Antibodies, Monoclonal; Arginine; Binding, Competitive; Enzyme-Linked Immunosorbent Assay; Humans; Nitric Oxide Synthase

2012
Endothelial nitric oxide synthase enhancer for protection of endothelial function from asymmetric dimethylarginine-induced injury in human internal thoracic artery.
    The Journal of thoracic and cardiovascular surgery, 2012, Volume: 144, Issue:3

    Topics: Acetylcholine; Aged; Antioxidants; Arginine; Benzodioxoles; Blotting, Western; Cytoprotection; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Female; Humans; In Vitro Techniques; Indans; Male; Mammary Arteries; Middle Aged; Myography; Nitric Oxide Synthase Type III; Superoxides; Vascular Patency; Vasodilation; Vasodilator Agents

2012
The dual behavior of heat shock protein 70 and asymmetric dimethylarginine in relation to serum CRP levels in type 2 diabetes.
    Gene, 2012, Apr-25, Volume: 498, Issue:1

    Topics: Adult; Arginine; C-Reactive Protein; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; HSP70 Heat-Shock Proteins; Humans; Inflammation Mediators; Male; Middle Aged; Nitric Oxide

2012
Anti-hypertensive effects of shichimotsukokato in 5/6 nephrectomized Wistar rats mediated by the DDAH-ADMA-NO pathway.
    Journal of natural medicines, 2012, Volume: 66, Issue:4

    Topics: Amidohydrolases; Animals; Antihypertensive Agents; Arginine; Hypertension; Nephrectomy; Nitric Oxide; Plant Extracts; Protein-Arginine N-Methyltransferases; Rats; Rats, Wistar; Signal Transduction

2012
Role of the human erythrocyte in generation and storage of asymmetric dimethylarginine.
    American journal of physiology. Heart and circulatory physiology, 2012, Apr-15, Volume: 302, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acids; Arginine; Biological Transport; Blood Proteins; Chromatography, High Pressure Liquid; Critical Illness; Erythrocytes; Female; Humans; Hydrolysis; In Vitro Techniques; Male; Middle Aged; Proteasome Endopeptidase Complex; Protein Binding; Solid Phase Extraction; Young Adult

2012
Birth by cesarean section is associated with elevated neonatal plasma levels of dimethylarginines.
    Pediatrics international : official journal of the Japan Pediatric Society, 2012, Volume: 54, Issue:4

    Topics: Arginine; Cesarean Section; Delivery, Obstetric; Female; Humans; Infant, Newborn; Male; Pregnancy

2012
Pravastatin inhibits advanced glycation end products (AGEs)-induced proximal tubular cell apoptosis and injury by reducing receptor for AGEs (RAGE) level.
    Metabolism: clinical and experimental, 2012, Volume: 61, Issue:8

    Topics: Amidohydrolases; Apoptosis; Arginine; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Fluorobenzenes; Glycation End Products, Advanced; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Tubules, Proximal; Pravastatin; Pyrimidines; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rosuvastatin Calcium; Sulfonamides; Up-Regulation

2012
High tea and vegetable consumption is associated with low ADMA generation in older healthy subjects.
    Metabolism: clinical and experimental, 2012, Volume: 61, Issue:8

    Topics: Aged; Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Coffee; Enzyme Inhibitors; Feeding Behavior; Female; Fruit; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Nitric Oxide Synthase; Reference Values; Risk Factors; Tea; Vegetables

2012
Elevation of serum asymmetrical and symmetrical dimethylarginine in patients with advanced glaucoma.
    Investigative ophthalmology & visual science, 2012, Apr-18, Volume: 53, Issue:4

    Topics: Aged; Arginine; Biomarkers; Female; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Male; Nitric Oxide Synthase; Retrospective Studies; Severity of Illness Index; Tandem Mass Spectrometry

2012
Nitric oxide and L-arginine metabolism in a devascularized porcine model of acute liver failure.
    American journal of physiology. Gastrointestinal and liver physiology, 2012, Aug-01, Volume: 303, Issue:3

    Topics: Animals; Arginase; Arginine; Citrulline; Disease Models, Animal; Female; Liver; Liver Failure, Acute; Nitric Oxide; Ornithine; Portacaval Shunt, Surgical; Sus scrofa

2012
HIV replication, inflammation, and the effect of starting antiretroviral therapy on plasma asymmetric dimethylarginine, a novel marker of endothelial dysfunction.
    Journal of acquired immune deficiency syndromes (1999), 2012, Jun-01, Volume: 60, Issue:2

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Arginine; Biomarkers; CD40 Antigens; Female; HIV Infections; Humans; Inflammation; Male; Middle Aged; P-Selectin; Plasma; Randomized Controlled Trials as Topic; Virus Replication

2012
Plasma asymmetric dimethylarginine and mortality in patients with acute decompensation of chronic heart failure.
    Heart (British Cardiac Society), 2012, Volume: 98, Issue:11

    Topics: Aged; Arginine; Biomarkers; Endothelium, Vascular; Enzyme Inhibitors; Female; Follow-Up Studies; Greece; Heart Failure; Hospitals, University; Humans; Incidence; Inpatients; Kaplan-Meier Estimate; Length of Stay; Male; Predictive Value of Tests; Prognosis; Risk Assessment; Sensitivity and Specificity; Stroke Volume; Survival Rate

2012
Pilot study of the association of the DDAH2 -449G polymorphism with asymmetric dimethylarginine and hemodynamic shock in pediatric sepsis.
    PloS one, 2012, Volume: 7, Issue:3

    Topics: Adolescent; Amidohydrolases; Arginine; Base Sequence; Child; DNA Primers; Genetic Association Studies; Genotype; Hemodynamics; Humans; Molecular Sequence Data; Nitric Oxide; Pilot Projects; Polymorphism, Single Nucleotide; Prospective Studies; Racial Groups; Sequence Analysis, DNA; Sex Factors; Shock, Septic; Tandem Mass Spectrometry

2012
Asymmetric dimethylarginine: a novel cardiovascular risk factor in end-stage renal disease.
    The Journal of international medical research, 2012, Volume: 40, Issue:1

    Topics: Arginine; Cardiovascular Diseases; Carotid Intima-Media Thickness; Demography; Female; Humans; Indonesia; Kidney Failure, Chronic; Linear Models; Male; Middle Aged; Renal Dialysis; Risk Factors

2012
Pulmonary hypertension associated with advanced systolic heart failure: dysregulated arginine metabolism and importance of compensatory dimethylarginine dimethylaminohydrolase-1.
    Journal of the American College of Cardiology, 2012, Mar-27, Volume: 59, Issue:13

    Topics: Aged; Amidohydrolases; Arginine; Disease Progression; Female; Heart Failure, Systolic; Humans; Hypertension, Pulmonary; Male; Middle Aged

2012
Nitric oxide synthase, ADMA, SDMA, and nitric oxide activity in the paraventricular nucleus throughout the etiology of renal wrap hypertension.
    American journal of physiology. Heart and circulatory physiology, 2012, Jun-01, Volume: 302, Issue:11

    Topics: Animals; Arginine; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Hypertension, Renal; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley

2012
ADMA and NOS regulation in chronic renal disease: beyond the old rivalry for l-arginine.
    Kidney international, 2012, Volume: 81, Issue:8

    Topics: Animals; Arginine; Humans; Male; Nitric Oxide Synthase Type III; Renal Insufficiency, Chronic

2012
Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2012, Volume: 13, Issue:4

    Topics: Adolescent; Arginine; Carnitine; Case-Control Studies; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Prospective Studies; Sepsis

2012
Asymmetric dimethylarginine in adults with cystathionine β-synthase deficiency.
    Atherosclerosis, 2012, Volume: 222, Issue:2

    Topics: Adult; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Endothelium, Vascular; Homocysteine; Homocystinuria; Humans

2012
Dimethylarginine dimethylaminohydrolase 1 regulates nerve growth factor-promoted differentiation of PC12 cells in a nitric oxide-dependent but asymmetric dimethylargenine-independent manner.
    Journal of neuroscience research, 2012, Volume: 90, Issue:6

    Topics: Amidohydrolases; Analysis of Variance; Animals; Arginine; Cell Differentiation; Enzyme Inhibitors; Microtubule-Associated Proteins; Nerve Growth Factor; Neurites; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; PC12 Cells; Rats; RNA, Messenger; Transfection

2012
Human hemoglobin does not contain asymmetric dimethylarginine (ADMA).
    Nitric oxide : biology and chemistry, 2012, Jun-30, Volume: 27, Issue:1

    Topics: Animals; Arginine; Erythrocytes; Gas Chromatography-Mass Spectrometry; Hemoglobins; Hemolysis; Humans; Linear Models; Mice

2012
Reduced plasma levels of asymmetric di-methylarginine (ADMA) in patients with alcohol dependence normalize during withdrawal.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2012, Volume: 22, Issue:11

    Topics: Adult; Alcoholism; Arginine; Diagnostic and Statistical Manual of Mental Disorders; Germany; Homocysteine; Humans; Hyperhomocysteinemia; International Classification of Diseases; Male; Middle Aged; Nitric Oxide Synthase; Pilot Projects; Prospective Studies; Risk Factors; Severity of Illness Index; Substance Withdrawal Syndrome; Time Factors; Vascular Diseases

2012
Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine in patients with arteriogenic and non-arteriogenic erectile dysfunction.
    International journal of andrology, 2012, Volume: 35, Issue:5

    Topics: Adult; Arginine; Erectile Dysfunction; Humans; Impotence, Vasculogenic; Male; Middle Aged

2012
Elevated homocysteine and asymmetric dimethyl arginine levels in pulmonary hypertension associated with congenital heart disease.
    Pediatric cardiology, 2012, Volume: 33, Issue:8

    Topics: Adolescent; Adult; Arginine; Biomarkers; Cardiac Catheterization; Case-Control Studies; Child; Child, Preschool; Echocardiography; Enzyme-Linked Immunosorbent Assay; Familial Primary Pulmonary Hypertension; Heart Defects, Congenital; Hemodynamics; Homocysteine; Humans; Hypertension, Pulmonary; Infant; Nitric Oxide; Predictive Value of Tests; ROC Curve; Sensitivity and Specificity; Statistics, Nonparametric

2012
Relationship between serum asymmetric dimethylarginine and left ventricular structure and function in patients with end‑stage renal disease treated with hemodialysis.
    Polskie Archiwum Medycyny Wewnetrznej, 2012, Volume: 122, Issue:5

    Topics: Arginine; Biomarkers; Echocardiography; Female; Heart Ventricles; Humans; Hypertrophy, Left Ventricular; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Ventricular Dysfunction, Left

2012
Flow-evoked vasodilation is blunted in penile arteries from Zucker diabetic fatty rats.
    The journal of sexual medicine, 2012, Volume: 9, Issue:7

    Topics: Animals; Arginine; Arteries; Cyclooxygenase Inhibitors; Indomethacin; Male; Myography; Nitric Oxide Synthase; Penis; Peptides; Potassium Channels, Calcium-Activated; Rats; Rats, Zucker; Vasodilation

2012
Reduced renal plasma clearance does not explain increased plasma asymmetric dimethylarginine in hypertensive subjects with mild to moderate renal insufficiency.
    American journal of physiology. Renal physiology, 2012, Jul-01, Volume: 303, Issue:1

    Topics: Adult; Aged; Arginine; Female; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Kidney Function Tests; Male; Middle Aged; Regional Blood Flow; Renal Insufficiency

2012
The association between serum asymmetric dimethyl arginine levels and a history of gestational diabetes among healthy women.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2012, Volume: 23, Issue:5

    Topics: Adult; Arginine; Asymptomatic Diseases; Biomarkers; Blood Glucose; Body Mass Index; Cardiovascular Diseases; Case-Control Studies; Diabetes Complications; Diabetes, Gestational; Fasting; Female; Glucose Tolerance Test; Humans; Insulin; Pregnancy; Risk Factors

2012
Plasma asymmetric dimethylarginine in patients with acute decompensation of chronic heart failure.
    Heart (British Cardiac Society), 2012, Volume: 98, Issue:11

    Topics: Arginine; Enzyme Inhibitors; Female; Heart Failure; Humans; Male

2012
Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I.
    Free radical biology & medicine, 2012, Jul-15, Volume: 53, Issue:2

    Topics: Acetylcarnitine; Adaptor Proteins, Signal Transducing; Animals; Animals, Newborn; Arginine; Biopterins; Disease Models, Animal; Endothelial Cells; Female; GTP Cyclohydrolase; HSP70 Heat-Shock Proteins; Hypertension, Pulmonary; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Pregnancy; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pulmonary Artery; Pulmonary Heart Disease; Sheep; Signal Transduction; Ubiquitin-Protein Ligases; Ubiquitination

2012
Impairment of the extrusion transporter for asymmetric dimethyl-L-arginine: a novel mechanism underlying vasospastic angina.
    Biochemical and biophysical research communications, 2012, Jun-29, Volume: 423, Issue:2

    Topics: Adult; Angina Pectoris; Arginine; Blood Platelets; Coronary Vasospasm; Endothelium, Vascular; Enzyme Inhibitors; Humans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Superoxides

2012
Effect of endoscopic sinus surgery on plasma asymmetric dimethylarginine levels in patients with extensive nasal polyposis.
    The Journal of international medical research, 2012, Volume: 40, Issue:2

    Topics: Adult; Arginine; Blood Pressure; Endoscopy; Female; Humans; Male; Nasal Polyps; Paranasal Sinuses; Pulmonary Artery

2012
L-arginine and asymmetric dimethylarginine are early predictors for survival in septic patients with acute liver failure.
    Mediators of inflammation, 2012, Volume: 2012

    Topics: Aged; Arginine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Liver Failure, Acute; Male; Middle Aged; Multiple Organ Failure; Nitric Oxide; ROC Curve; Sepsis; Shock, Septic; Time Factors; Treatment Outcome

2012
Paraoxonase lactonase activity (PON-HTLase), asymmetric dimethylarginine (ADMA) and platelet activating factor-acetylhydrolase (PAF-AH) activity in non-obese women with PCOS.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2012, Volume: 28, Issue:11

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Adolescent; Adult; Arginine; Aryldialkylphosphatase; Body Mass Index; Case-Control Studies; Female; Humans; Obesity; Polycystic Ovary Syndrome; Young Adult

2012
Effect of vitamin D on aortic remodeling in streptozotocin-induced diabetes.
    Cardiovascular diabetology, 2012, Jul-13, Volume: 11

    Topics: Animals; Aorta, Thoracic; Aortic Diseases; Arginine; Biomarkers; Blood Pressure; Cholecalciferol; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dietary Supplements; Elastic Tissue; Elasticity; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Male; Pulsatile Flow; Radioimmunoassay; Rats; Rats, Wistar; Streptozocin; Time Factors; Vasoconstrictor Agents; Vasodilator Agents; Vitamin D

2012
Asymmetric dimethylarginine reduces nitric oxide donor-mediated dilation of arterioles by activating the vascular renin-angiotensin system and reactive oxygen species.
    Journal of vascular research, 2012, Volume: 49, Issue:4

    Topics: Acetophenones; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Arterioles; Catalase; Male; Muscle, Skeletal; NADPH Oxidases; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxidative Stress; Pyrogallol; Rats; Rats, Wistar; Reactive Oxygen Species; Renin-Angiotensin System; Superoxide Dismutase; Vasodilation; Xanthine Oxidase

2012
Oxidative stress in hypertensive children before and after 1 year of antihypertensive therapy.
    Pediatric nephrology (Berlin, Germany), 2012, Volume: 27, Issue:10

    Topics: Adiposity; Adolescent; Albuminuria; Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arginine; Biomarkers; Blood Pressure; C-Reactive Protein; Carotid Artery Diseases; Carotid Intima-Media Thickness; Chi-Square Distribution; Child; Child, Preschool; Cholesterol, LDL; Female; Glutathione Peroxidase; Humans; Hypertension; Hypertrophy, Left Ventricular; Insulin Resistance; Lipoproteins, LDL; Male; Metabolic Syndrome; Oxidative Stress; Poland; Severity of Illness Index; Thiobarbituric Acid Reactive Substances; Time Factors; Treatment Outcome

2012
Assessment of endothelial function in patients with nonalcoholic fatty liver disease.
    Endocrine, 2013, Volume: 43, Issue:1

    Topics: Adult; Arginine; Atherosclerosis; Brachial Artery; Carotid Arteries; Carotid Intima-Media Thickness; Case-Control Studies; Early Diagnosis; Endothelium, Vascular; Fatty Liver; Female; Humans; Insulin Resistance; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Practice Guidelines as Topic; Predictive Value of Tests; Severity of Illness Index; Vascular Diseases; Vasodilation

2013
Plasma fetuin-A is associated with endothelial dysfunction and subclinical atherosclerosis in subjects with nonalcoholic fatty liver disease.
    Clinical endocrinology, 2013, Volume: 78, Issue:5

    Topics: Adiponectin; Adult; alpha-2-HS-Glycoprotein; Arginine; Atherosclerosis; Carotid Artery Diseases; Carotid Intima-Media Thickness; Fatty Liver; Female; Humans; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Young Adult

2013
Diagnostic value of plasma asymmetric and symmetric dimethylarginine levels in liver transplant recipients.
    Polskie Archiwum Medycyny Wewnetrznej, 2012, Volume: 122, Issue:7-8

    Topics: Alanine Transaminase; Arginine; Aspartate Aminotransferases; Biomarkers; Cadaver; Fibrosis; Humans; Kidney Transplantation; Predictive Value of Tests; Renal Insufficiency, Chronic

2012
The effect of valsartan and nebivolol treatment on ADMA and pentraxin-3 levels in hypertensive patients.
    Medical hypotheses, 2012, Volume: 79, Issue:3

    Topics: Adult; Antihypertensive Agents; Arginine; Benzopyrans; C-Reactive Protein; Ethanolamines; Female; Humans; Hypertension; Male; Middle Aged; Nebivolol; Serum Amyloid P-Component; Tetrazoles; Valine; Valsartan

2012
Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (CAT1).
    Journal of molecular and cellular cardiology, 2012, Volume: 53, Issue:3

    Topics: Arginine; Biological Transport; Biomarkers; Cardiovascular Diseases; Cationic Amino Acid Transporter 1; Gene Expression; HEK293 Cells; Humans; Kinesics; Metformin; Risk

2012
Relationship between plasma asymmetric dimethylarginine level and autonomic dysfunction in diabetic patients.
    Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2012, Volume: 40, Issue:2

    Topics: Administration, Oral; Arginine; Autonomic Nervous System Diseases; Case-Control Studies; Diabetes Mellitus, Type 2; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged

2012
Aqueous humour and serum concentration of asymmetric dimethyl arginine in pseudoexfoliation syndrome.
    The British journal of ophthalmology, 2012, Volume: 96, Issue:8

    Topics: Aged; Aqueous Humor; Arginine; Cataract; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Exfoliation Syndrome; Female; Gonioscopy; Humans; Intraocular Pressure; Male; Nitric Oxide Synthase; Tonometry, Ocular

2012
Screening of substrates of protein arginine methyltransferase 1 in glioma.
    Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 2012, Volume: 27, Issue:1

    Topics: Arginine; Cell Line, Tumor; Chromatography, Liquid; Glioma; Humans; Immunoprecipitation; Protein-Arginine N-Methyltransferases; Repressor Proteins; Substrate Specificity; Tandem Mass Spectrometry

2012
Proteinuria elevates asymmetric dimethylarginine levels via protein arginine methyltransferase-1 overexpression in a rat model of nephrotic syndrome.
    Life sciences, 2012, Sep-24, Volume: 91, Issue:9-10

    Topics: Acetylcysteine; Animals; Antioxidants; Arginine; Cells, Cultured; Disease Models, Animal; Doxorubicin; Epithelial Cells; Gene Expression Regulation, Enzymologic; Humans; Kidney Tubules, Proximal; Male; Nephrotic Syndrome; Oxidative Stress; Protein-Arginine N-Methyltransferases; Proteinuria; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Serum Albumin; Time Factors

2012
Do cardiac risk factors affect the homocysteine and asymmetric dimethylarginine relationship in patients with coronary artery diseases?
    Clinical biochemistry, 2012, Volume: 45, Issue:16-17

    Topics: Adult; Aged; Arginine; Atherosclerosis; Coronary Artery Disease; Female; Homocysteine; Humans; Male; Middle Aged; Regression Analysis; Risk Factors

2012
Regulation of endothelial nitric oxide synthase and asymmetric dimethylarginine by matrine attenuates isoproterenol-induced acute myocardial injury in rats.
    The Journal of pharmacy and pharmacology, 2012, Volume: 64, Issue:8

    Topics: Alkaloids; Amidohydrolases; Animals; Arginine; Catechol O-Methyltransferase; Glycogen Synthase Kinases; Heart Ventricles; Isoproterenol; Male; Matrines; Myocardial Ischemia; Myocardium; Necrosis; Nitric Oxide Synthase Type III; Phosphorylation; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-akt; Quinolizines; Rats; Rats, Sprague-Dawley; Sophora

2012
The role of homocysteine, asymmetric dimethylarginine and nitric oxide in pre-eclampsia.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2012, Volume: 32, Issue:6

    Topics: Adult; Arginine; Case-Control Studies; Female; Homocysteine; Humans; Nitric Oxide; Pre-Eclampsia; Pregnancy; Young Adult

2012
Asymmetric dimethylarginine, an endogenous NOS inhibitor, is actively metabolized in rat erythrocytes.
    Bioscience, biotechnology, and biochemistry, 2012, Volume: 76, Issue:7

    Topics: Amidohydrolases; Amino Acid Sequence; Animals; Arginine; Catalase; Enzyme Inhibitors; Erythrocytes; Gene Expression; Humans; Male; Mice; Molecular Sequence Data; Nitric Oxide; Nitric Oxide Synthase; Protein Binding; Protein-Arginine N-Methyltransferases; Rats

2012
The CSF concentration of ADMA, but not of ET-1, is correlated with the occurrence and severity of cerebral vasospasm after subarachnoid hemorrhage.
    Neuroscience letters, 2012, Aug-22, Volume: 524, Issue:1

    Topics: Adult; Arginine; Brain Ischemia; Endothelin-1; Female; Humans; Male; Middle Aged; Nitric Oxide; Retrospective Studies; Severity of Illness Index; Subarachnoid Hemorrhage; Vasodilation; Vasospasm, Intracranial

2012
Biological signatures of asymptomatic extra- and intracranial atherosclerosis: the Barcelona-AsIA (Asymptomatic Intracranial Atherosclerosis) study.
    Stroke, 2012, Volume: 43, Issue:10

    Topics: Aged; Arginine; Biomarkers; C-Reactive Protein; Carotid Artery Diseases; Cohort Studies; Cross-Sectional Studies; Diabetes Complications; Female; Humans; Insulin Resistance; Intracranial Arteriosclerosis; Longitudinal Studies; Male; Metabolic Syndrome; Middle Aged; Plasminogen Activator Inhibitor 1; Regression Analysis; Resistin; Risk Factors; Spain

2012
Clinical remission following treatment with tumour necrosis factor-alpha antagonists is not accompanied by changes in asymmetric dimethylarginine in patients with rheumatoid arthritis.
    Clinical biochemistry, 2012, Volume: 45, Issue:16-17

    Topics: Adult; Aged; Antirheumatic Agents; Arginine; Arthritis, Rheumatoid; Biomarkers; Female; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Remission Induction; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor-alpha

2012
[The role of asymmetric dimethylarginine in the regulation of nitric oxide level in rats with acute renal injury].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2012, Volume: 98, Issue:4

    Topics: Acute Kidney Injury; Amidohydrolases; Animals; Arginine; Glycerol; Kidney; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar

2012
Mechanism of cellular oxidation stress induced by asymmetric dimethylarginine.
    International journal of molecular sciences, 2012, Volume: 13, Issue:6

    Topics: Arginine; Biopterins; Enzyme Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; Lysine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress

2012
Elevated asymmetric dimethylarginine in young adult survivors of childhood acute lymphoblastic leukemia: a preliminary report.
    Disease markers, 2012, Volume: 33, Issue:2

    Topics: Adolescent; Adult; Arginine; Cardiovascular Diseases; Female; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Survivors

2012
Binding of the heterogeneous ribonucleoprotein K (hnRNP K) to the Epstein-Barr virus nuclear antigen 2 (EBNA2) enhances viral LMP2A expression.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Antibodies, Monoclonal; Antibody Specificity; Arginine; Cell Line; DNA; Epstein-Barr Virus Infections; Epstein-Barr Virus Nuclear Antigens; Gene Expression Regulation, Viral; Herpesvirus 4, Human; Heterogeneous-Nuclear Ribonucleoprotein K; Humans; Immunoprecipitation; Methylation; Molecular Sequence Data; Multiprotein Complexes; Mutant Proteins; Promoter Regions, Genetic; Protein Binding; Protein Transport; Repetitive Sequences, Amino Acid; snRNP Core Proteins; Transfection; Viral Matrix Proteins; Viral Proteins

2012
Inflammatory processes and effects of continuous positive airway pressure (CPAP) in overlap syndrome.
    Inflammation, 2013, Volume: 36, Issue:1

    Topics: Arginine; C-Reactive Protein; Continuous Positive Airway Pressure; Humans; Inflammation; Inflammation Mediators; Male; Middle Aged; Polysomnography; Pulmonary Disease, Chronic Obstructive; Sleep Apnea, Obstructive; Snoring; Spirometry; Tumor Necrosis Factor-alpha

2013
The protection by heme oxygenase-1 induction against thioacetamide-induced liver toxicity is associated with changes in arginine and asymmetric dimethylarginine.
    Cell biochemistry and function, 2013, Volume: 31, Issue:2

    Topics: Alanine Transaminase; Animals; Arginase; Arginine; Aspartate Aminotransferases; Blotting, Western; Enzyme Induction; Glutathione; Glutathione Peroxidase; Heme Oxygenase-1; Liver; Liver Diseases; Male; Malondialdehyde; Nitric Oxide Synthase Type II; Protective Agents; Rats; Rats, Wistar; Superoxide Dismutase; Thioacetamide

2013
Asymmetric dimethylarginine is strongly associated with cognitive dysfunction and brain MR spectroscopic abnormalities in cirrhosis.
    Journal of hepatology, 2013, Volume: 58, Issue:1

    Topics: Adult; Arginine; Aspartic Acid; Biomarkers; Brain; Cognition Disorders; Cross-Sectional Studies; Female; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Inositol; Liver Cirrhosis; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prospective Studies

2013
AVE3085 protects coronary endothelium from the impairment of asymmetric dimethylarginine by activation and recoupling of eNOS.
    Cardiovascular drugs and therapy, 2012, Volume: 26, Issue:5

    Topics: Animals; Arginine; Benzodioxoles; Cardiotonic Agents; Coronary Vessels; Endothelium, Vascular; In Vitro Techniques; Indans; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxygen; Superoxides; Swine; Vasodilation

2012
Diagnostical significance of dimethylarginine in the development of hepatorenal syndrome in patients with alcoholic liver cirrhosis.
    Vojnosanitetski pregled, 2012, Volume: 69, Issue:8

    Topics: Adult; Aged; Arginine; Biomarkers; Creatinine; Disease Progression; Hepatorenal Syndrome; Humans; Liver Cirrhosis, Alcoholic; Male; Middle Aged

2012
Subarachnoid haemorrhage induces an inflammatory response followed by a delayed persisting increase in asymmetric dimethylarginine.
    Scandinavian journal of clinical and laboratory investigation, 2012, Volume: 72, Issue:6

    Topics: Acute-Phase Reaction; Arginine; Biomarkers; C-Reactive Protein; Case-Control Studies; Female; Humans; Inflammation; Male; Middle Aged; Subarachnoid Hemorrhage

2012
Serum asymmetric dimethylarginine, apelin, and tumor necrosis factor-α levels in non-obese women with polycystic ovary syndrome.
    Steroids, 2012, Volume: 77, Issue:13

    Topics: Apelin; Arginine; Body Mass Index; Case-Control Studies; Female; Humans; Hyperandrogenism; Intercellular Signaling Peptides and Proteins; Polycystic Ovary Syndrome; Tumor Necrosis Factor-alpha; Young Adult

2012
Plasma concentrations of asymmetric dimethylarginine, nitric oxide and homocysteine in patients with slow coronary flow.
    Scandinavian journal of clinical and laboratory investigation, 2012, Volume: 72, Issue:6

    Topics: Arginine; Case-Control Studies; Coronary Angiography; Coronary Circulation; Demography; Female; Hemorheology; Homocysteine; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Nitric Oxide

2012
Assessment of the endothelial functions in monocrotaline-induced pulmonary hypertension.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2013, Volume: 35, Issue:3

    Topics: Animals; Aorta, Thoracic; Arginine; Disease Models, Animal; Endothelium, Vascular; Hydrogen Sulfide; Hypertension, Pulmonary; Iloprost; Male; Monocrotaline; Nitric Oxide; Piperazines; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Vasodilation; Vasodilator Agents

2013
Oxidative stress in patients with essential hypertension: a comparison of dippers and non-dippers.
    European journal of internal medicine, 2013, Volume: 24, Issue:2

    Topics: Antioxidants; Arginine; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Female; Humans; Hypertension; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Prospective Studies; Tyrosine

2013
Estradiol, acting through estrogen receptor alpha, restores dimethylarginine dimethylaminohydrolase activity and nitric oxide production in oxLDL-treated human arterial endothelial cells.
    Molecular and cellular endocrinology, 2013, Jan-05, Volume: 365, Issue:1

    Topics: Amidohydrolases; Arginine; Blotting, Western; Cells, Cultured; Endothelium, Vascular; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens, Non-Steroidal; Humans; Isoenzymes; Lipoproteins, LDL; Nitric Oxide; Nitric Oxide Synthase Type III; Protein Stability; Protein-Arginine N-Methyltransferases; Receptors, Estrogen; Receptors, G-Protein-Coupled; Repressor Proteins; Umbilical Arteries

2013
Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome.
    Reproductive biomedicine online, 2012, Volume: 25, Issue:5

    Topics: Adult; Arginine; Biomarkers; Cardiovascular Diseases; Female; Humans; Intercellular Adhesion Molecule-1; Plasminogen Activator Inhibitor 1; Polycystic Ovary Syndrome; Vascular Cell Adhesion Molecule-1; Waist Circumference; Weight Loss

2012
Nitric oxide and carbon monoxide production and metabolism in preeclampsia.
    Reproductive sciences (Thousand Oaks, Calif.), 2013, Volume: 20, Issue:5

    Topics: Adult; Amidohydrolases; Arginine; Biomarkers; Blotting, Western; Carbon Monoxide; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Heme Oxygenase-1; Humans; Nitric Oxide; Placenta; Pre-Eclampsia; Predictive Value of Tests; Pregnancy; Prospective Studies; Young Adult

2013
The L-arginine/asymmetric dimethylarginine ratio is improved by anti-tumor necrosis factor-α therapy in inflammatory arthropathies. Associations with aortic stiffness.
    Atherosclerosis, 2012, Volume: 225, Issue:1

    Topics: Adult; Antirheumatic Agents; Aorta; Arginine; Arthritis, Psoriatic; Arthritis, Rheumatoid; Blood Pressure; Carotid Intima-Media Thickness; Female; Humans; Male; Middle Aged; Pulse Wave Analysis; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha; Vascular Stiffness

2012
INF-β1b therapy modulates L-arginine and nitric oxide metabolism in patients with relapse remittent multiple sclerosis.
    Journal of the neurological sciences, 2012, Dec-15, Volume: 323, Issue:1-2

    Topics: Adult; Arginase; Arginine; Biomarkers; Drug Monitoring; Female; Follow-Up Studies; Humans; Inflammation; Interferon beta-1b; Interferon-beta; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Nitrates; Nitric Oxide; Nitrites; Nitroso Compounds; Severity of Illness Index; Sulfhydryl Compounds; Tyrosine; Young Adult

2012
Actin cytoskeleton-dependent pathways for ADMA-induced NF-κB activation and TGF-β high expression in human renal glomerular endothelial cells.
    Acta biochimica et biophysica Sinica, 2012, Volume: 44, Issue:11

    Topics: Actins; Arginine; Base Sequence; Blotting, Western; Cells, Cultured; Cytoskeleton; DNA Primers; Electrophoretic Mobility Shift Assay; Endothelium; Humans; Kidney Glomerulus; NF-kappa B; Real-Time Polymerase Chain Reaction; Transforming Growth Factor beta

2012
Compensatory feto-placental upregulation of the nitric oxide system during fetal growth restriction.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Adaptation, Physiological; Adult; Arginine; Endothelial Cells; Endothelium, Vascular; Female; Fetal Blood; Fetal Growth Retardation; Fetus; Gene Expression Profiling; Hemoglobins; Humans; Infant, Low Birth Weight; Infant, Newborn; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Placenta; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; Ultrasonography; Umbilical Arteries; Umbilical Veins; Up-Regulation

2012
Feto-placental nitric oxide, asymmetric dimethylarginine and vascular endothelial growth factor (VEGF) levels and VEGF gene polymorphisms in severe preeclampsia.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2013, Volume: 26, Issue:3

    Topics: Adolescent; Adult; Arginine; Case-Control Studies; Female; Fetal Blood; Genetic Predisposition to Disease; Humans; Infant, Newborn; Nitric Oxide; Pilot Projects; Placenta; Placental Circulation; Polymorphism, Single Nucleotide; Pre-Eclampsia; Pregnancy; Severity of Illness Index; Umbilical Veins; Vascular Endothelial Growth Factor A; Young Adult

2013
Asymmetrical dimethylarginine antagonizes glutamate-induced apoptosis in PC12 cells.
    Journal of molecular neuroscience : MN, 2013, Volume: 49, Issue:1

    Topics: Animals; Apoptosis; Arginine; Caspase 3; Glutamic Acid; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Rats

2013
Changes in ghrelin and asymmetrical dimethylarginine in obese Mexican adolescents after six-month lifestyle intervention.
    Endocrine, 2013, Volume: 43, Issue:3

    Topics: Adolescent; Arginine; Body Mass Index; Child; Eating; Feeding Behavior; Female; Ghrelin; Humans; Insulin Resistance; Life Style; Male; Mexico; Obesity; Surveys and Questionnaires

2013
Recognition of asymmetrically dimethylated arginine by TDRD3.
    Nucleic acids research, 2012, Volume: 40, Issue:22

    Topics: Amino Acid Sequence; Amino Acids; Arginine; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Mutation; Protein Structure, Tertiary; Proteins; Sequence Alignment

2012
Asymmetric and symmetric dimethylarginine and risk of secondary cardiovascular disease events and mortality in patients with stable coronary heart disease: the KAROLA follow-up study.
    Clinical research in cardiology : official journal of the German Cardiac Society, 2013, Volume: 102, Issue:3

    Topics: Aged; Arginine; Biomarkers; Cause of Death; Chromatography, Liquid; Coronary Disease; Female; Follow-Up Studies; Germany; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Recurrence; Risk Assessment; Risk Factors; Tandem Mass Spectrometry; Time Factors

2013
Exploring disease activity and cardiovascular events by raised serum asymmetric dimethyl arginine among systemic lupus erythematosus patients.
    The Egyptian journal of immunology, 2011, Volume: 18, Issue:1

    Topics: Adult; Arginine; Cardiovascular Diseases; Cholesterol; Complement C3; Cross-Sectional Studies; Egypt; Female; Humans; Logistic Models; Lupus Erythematosus, Systemic; Male; Surveys and Questionnaires

2011
Asymmetric dimethylarginine predicts clinical outcomes in ischemic chronic heart failure.
    Atherosclerosis, 2012, Volume: 225, Issue:2

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Chi-Square Distribution; Chromatography, High Pressure Liquid; Coronary Angiography; Disease-Free Survival; Female; Heart Failure; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Myocardial Ischemia; Natriuretic Peptide, Brain; Peptide Fragments; Prognosis; Proportional Hazards Models; Risk Assessment; Risk Factors; Stroke Volume; Taiwan; Time Factors; Ultrasonography; Up-Regulation; Ventricular Function, Left

2012
Dimethylarginine dimethylaminohydrolase1 is an organ-specific mediator of end organ damage in a murine model of hypertension.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Heart; Humans; Hypertension; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic

2012
Left atrial volume index and aortic stiffness index in adult hemodialysed patients--link between compliance and pressure mediated by endothelium dysfunction; a cross-sectional study.
    BMC cardiovascular disorders, 2012, Nov-05, Volume: 12

    Topics: Adult; Aged; Arginine; Cross-Sectional Studies; Echocardiography; Endothelium, Vascular; Female; Heart Atria; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Nitric Oxide; Peptide Fragments; Renal Dialysis; Troponin T; Vascular Stiffness

2012
Chronic renal impairment and DDAH2-1151 A/C polymorphism determine ADMA levels in type 2 diabetic subjects.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2013, Volume: 28, Issue:4

    Topics: Aged; Amidohydrolases; Arginine; Case-Control Studies; Diabetes Complications; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Kidney Function Tests; Male; Middle Aged; Nitric Oxide; Polymorphism, Genetic; Prognosis; Renal Insufficiency, Chronic; Risk Factors

2013
Asymmetric dimethylarginine and carotid atherosclerosis in Type 2 diabetes mellitus.
    Journal of endocrinological investigation, 2012, Volume: 35, Issue:9

    Topics: Adult; Aged; Arginine; Carotid Artery Diseases; Case-Control Studies; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Prognosis

2012
ADMA, SDMA and L-arginine/ADMA ratio but not DDAH genetic polymorphisms are reliable predictors of diabetic nephropathy progression as identified by competing risk analysis.
    Kidney & blood pressure research, 2012, Volume: 36, Issue:1

    Topics: Adult; Aged; Amidohydrolases; Arginine; Cross-Sectional Studies; Czech Republic; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Female; Follow-Up Studies; Humans; Male; Methylation; Middle Aged; Multivariate Analysis; Polymorphism, Single Nucleotide; Predictive Value of Tests; Prognosis; Reproducibility of Results; Risk Factors

2012
Impact of ADMA, endothelial progenitor cells and traditional cardiovascular risk factors on pulse wave velocity among prediabetic individuals.
    Cardiovascular diabetology, 2012, Nov-15, Volume: 11

    Topics: Adult; Aged; Arginine; Biomarkers; Blood Glucose; Cardiovascular Diseases; Carotid Arteries; Cholesterol, LDL; Cross-Sectional Studies; Endothelial Cells; Fasting; Female; Femoral Artery; Glucose Tolerance Test; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Prediabetic State; Predictive Value of Tests; Pulse Wave Analysis; Risk Assessment; Risk Factors; Stem Cells; Vascular Stiffness

2012
Glucagon-like peptide-1 receptor agonist inhibits asymmetric dimethylarginine generation in the kidney of streptozotocin-induced diabetic rats by blocking advanced glycation end product-induced protein arginine methyltranferase-1 expression.
    The American journal of pathology, 2013, Volume: 182, Issue:1

    Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drug Evaluation, Preclinical; Exenatide; Gene Expression Regulation, Enzymologic; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycation End Products, Advanced; Humans; Hypertrophy; Hypoglycemic Agents; Kidney; Kidney Glomerulus; Kidney Tubules; Macrophages; Male; Peptides; Protein-Arginine N-Methyltransferases; Rats; Rats, Wistar; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Receptors, Glucagon; Receptors, Immunologic; Repressor Proteins; RNA, Messenger; Venoms

2013
Protection of DDAH2 overexpression against homocysteine-induced impairments of DDAH/ADMA/NOS/NO pathway in endothelial cells.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2012, Volume: 30, Issue:6

    Topics: Amidohydrolases; Arginine; Cells, Cultured; Endothelium; Gene Expression; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Hyperhomocysteinemia; L-Lactate Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase Type III; Signal Transduction

2012
Serum asymmetric dimethylarginine levels are independently associated with procollagen III N-terminal peptide in nonalcoholic fatty liver disease patients.
    Clinical and experimental medicine, 2014, Volume: 14, Issue:1

    Topics: Adult; Aged; Arginine; Fatty Liver; Female; Humans; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Peptide Fragments; Procollagen; Serum

2014
The relationship of plasma ADMA levels with cardiac functions and metabolic parameters in peritoneal dialysis patients.
    Clinical and experimental nephrology, 2013, Volume: 17, Issue:3

    Topics: Adolescent; Aged; Arginine; Aspirin; Body Mass Index; Cardiovascular Diseases; Cross-Sectional Studies; Echocardiography; Heart; Humans; Hypertension; Middle Aged; Peritoneal Dialysis; Risk Factors

2013
Aminoguanidine attenuates hypertension, whereas 7-nitroindazole exacerbates kidney damage in spontaneously hypertensive rats: the role of nitric oxide.
    European journal of pharmacology, 2013, Jan-15, Volume: 699, Issue:1-3

    Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Citrulline; Guanidines; Hypertension; Indazoles; Kidney Diseases; Male; Nitric Oxide; Nitric Oxide Synthase Type I; Rats; Rats, Inbred SHR; Sodium Chloride, Dietary; Up-Regulation

2013
Asymmetric dimethylarginine plasma levels and endothelial function in newly diagnosed type 2 diabetic patients.
    International journal of molecular sciences, 2012, Oct-24, Volume: 13, Issue:11

    Topics: Arginine; Blood Pressure; Case-Control Studies; Diabetes Complications; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Humans; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Risk Factors

2012
Associations between endogenous dimethylarginines and renal function in healthy children and adolescents.
    International journal of molecular sciences, 2012, Nov-21, Volume: 13, Issue:11

    Topics: Adolescent; Arginine; Child; Child, Preschool; Creatinine; Female; Glomerular Filtration Rate; Healthy Volunteers; Humans; Kidney; Kidney Function Tests; Lipids; Male

2012
An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype.
    American journal of respiratory and critical care medicine, 2013, Jan-15, Volume: 187, Issue:2

    Topics: Adolescent; Adult; Age of Onset; Aged; Arginine; Asthma; Body Mass Index; Cross-Sectional Studies; Forced Expiratory Volume; Humans; Middle Aged; Nitric Oxide; Obesity; Phenotype; Young Adult

2013
The L-Arginine-asymmetric dimethylarginine ratio is an independent predictor of mortality in dilated cardiomyopathy.
    Journal of cardiac failure, 2012, Volume: 18, Issue:12

    Topics: Arginine; Biomarkers; Cardiomyopathies; Cardiomyopathy, Dilated; Chromatography, Liquid; Creatinine; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Myocardial Ischemia; Natriuretic Peptide, Brain; Peptide Fragments; Severity of Illness Index; Tandem Mass Spectrometry

2012
Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, interacts with gastric oxidative metabolism and enhances stress-induced gastric lesions.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2012, Volume: 63, Issue:5

    Topics: Aldehydes; Animals; Arginine; Enzyme Inhibitors; Gastric Mucosa; Glutathione Peroxidase; Interleukin-1beta; Lipid Peroxidation; Male; Malondialdehyde; Nitric Oxide Synthase; Rats; Rats, Wistar; Regional Blood Flow; Restraint, Physical; Stomach Ulcer; Stress, Psychological; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2012
Asymmetrical dimethylarginine level is independently associated with circulating levels of RAGE and PEDF.
    International journal of cardiology, 2013, Sep-10, Volume: 167, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Cross-Sectional Studies; Eye Proteins; Female; Humans; Male; Middle Aged; Nerve Growth Factors; Nitric Oxide Synthase; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Serpins

2013
Effect of chronic elevated asymmetric dimethylarginine (ADMA) levels on granulopoiesis.
    Annals of hematology, 2013, Volume: 92, Issue:4

    Topics: Animals; Arginine; Blood Cell Count; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Granulocytes; Hematopoiesis; Killer Cells, Natural; Leukocytes; Male; Rats; Rats, Sprague-Dawley; Time Factors

2013
Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow.
    Antioxidants & redox signaling, 2013, May-10, Volume: 18, Issue:14

    Topics: Adenosine Triphosphate; Animals; Arginine; Carnitine; Disease Models, Animal; Endothelial Cells; Heart Defects, Congenital; Homeostasis; Hypertension, Pulmonary; Lung; Mitochondria; Nitric Oxide; Nitric Oxide Synthase Type III; Pulmonary Circulation; Regional Blood Flow; Sheep; Signal Transduction

2013
Asymmetric dimethylarginine induces endothelial nitric-oxide synthase mitochondrial redistribution through the nitration-mediated activation of Akt1.
    The Journal of biological chemistry, 2013, Mar-01, Volume: 288, Issue:9

    Topics: Animals; Arginine; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Humans; Mice; Mitochondria; Mitochondrial Proteins; Nitric Oxide Synthase Type III; Oxygen Consumption; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Sheep

2013
Assessment of atherosclerosis risk due to the homocysteine-asymmetric dimethylarginine-nitric oxide cascade in children taking antiepileptic drugs.
    Seizure, 2013, Volume: 22, Issue:2

    Topics: Adolescent; Anticonvulsants; Arginine; Atherosclerosis; Biomarkers; Carbamazepine; Child; Epilepsy; Female; Homocysteine; Humans; Male; Nitric Oxide; Oxcarbazepine; Prospective Studies; Risk Factors; Valproic Acid

2013
Differences in the association between maternal serum homocysteine and ADMA levels in women with pregnancies complicated by preeclampsia and/or intrauterine growth restriction.
    Hypertension in pregnancy, 2013, Volume: 32, Issue:1

    Topics: Adult; Arginine; Case-Control Studies; Female; Fetal Growth Retardation; Homocysteine; Humans; Pre-Eclampsia; Pregnancy; Young Adult

2013
Impact of ADMA (asymmetric dimethylarginine) on physiology with respect to diabetes mellitus and respiratory system BEAS-2B cells (human bronchial epithelial cells).
    The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:2

    Topics: Animals; Arginine; Blood Glucose; Cell Line; Chemokine CXCL2; Diabetes Mellitus; Epithelial Cells; Female; Humans; Insulin; Insulin Resistance; Insulin-Secreting Cells; Interleukin-6; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Respiratory Mucosa; Trachea; Tumor Necrosis Factor-alpha

2013
Probing AGXT2 enzyme activity in mouse tissue by applying stable isotope-labeled asymmetric dimethyl arginine as substrate.
    Journal of mass spectrometry : JMS, 2012, Volume: 47, Issue:12

    Topics: Animals; Arginine; Chromatography, Liquid; Enzyme Stability; Guanidines; Hydrogen-Ion Concentration; Isotope Labeling; Keto Acids; Kidney; Liver; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Nitric Oxide; Reproducibility of Results; Tandem Mass Spectrometry; Transaminases

2012
Vaspin increases nitric oxide bioavailability through the reduction of asymmetric dimethylarginine in vascular endothelial cells.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Animals; Arginine; Blotting, Western; Cells, Cultured; Electrophoretic Mobility Shift Assay; Endothelial Cells; Humans; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Serpins

2012
Melatonin regulates L-arginine transport and NADPH oxidase in young rats with bile duct ligation: role of protein kinase C.
    Pediatric research, 2013, Volume: 73, Issue:4 Pt 1

    Topics: Animals; Arginase; Arginine; Biological Transport; Cationic Amino Acid Transporter 1; Cholestasis, Extrahepatic; Common Bile Duct; Disease Models, Animal; Female; Injections, Intraperitoneal; Kidney; Ligation; Liver; Male; Melatonin; NADPH Oxidases; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase Inhibitors; Protein Transport; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species

2013
Disruption of asymmetric dimethylarginine-induced RelA/P65 association with actin in endothelial cells.
    Acta biochimica et biophysica Sinica, 2013, Volume: 45, Issue:3

    Topics: Actins; Active Transport, Cell Nucleus; Arginine; Cell Nucleus; Cytoplasm; Endothelial Cells; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; NF-kappa B; Promoter Regions, Genetic; Protein Binding; Time Factors; Transcription Factor RelA; Vascular Cell Adhesion Molecule-1

2013
Effects of asymmetric dimethylarginine on inflammatory cytokines (TNF-α, IL-6 and IL-10) in rats.
    Toxicology and industrial health, 2015, Volume: 31, Issue:3

    Topics: Animals; Arginine; Dose-Response Relationship, Drug; Inflammation; Interleukin-10; Interleukin-6; Male; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha

2015
Predictors of asymmetric dimethylarginine levels in patients with rheumatoid arthritis: the role of insulin resistance.
    Scandinavian journal of rheumatology, 2013, Volume: 42, Issue:3

    Topics: Adult; Aged; Arginine; Arthritis, Rheumatoid; Female; Homeostasis; Humans; Insulin Resistance; Male; Middle Aged

2013
Clinical-biological phenotyping beyond inflammation in asthma delivers.
    American journal of respiratory and critical care medicine, 2013, Jan-15, Volume: 187, Issue:2

    Topics: Age of Onset; Arginine; Asthma; Humans; Obesity

2013
Asymmetric dimethyloarginin (ADMA) concentration in the aqueous humor of patients with exfoliation syndrome or exfoliative glaucoma.
    Current eye research, 2013, Volume: 38, Issue:2

    Topics: Aged; Aqueous Humor; Arginine; Cataract; Cataract Extraction; Exfoliation Syndrome; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Oxidative Stress

2013
Effect of atrial fibrillation on atrial thrombogenesis in humans: impact of rate and rhythm.
    Journal of the American College of Cardiology, 2013, Feb-26, Volume: 61, Issue:8

    Topics: Aged; Antithrombin III; Arginine; Atrial Fibrillation; Catheter Ablation; CD40 Ligand; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Heart Atria; Heart Rate; Humans; Male; Middle Aged; P-Selectin; Peptide Hydrolases; Platelet Activation; Risk Assessment; Risk Factors; Statistics as Topic; Stroke; Thrombosis

2013
MS³ fragmentation patterns of monomethylarginine species and the quantification of all methylarginine species in yeast using MRM³.
    Journal of proteomics, 2013, Mar-27, Volume: 80

    Topics: Arginine; Cell Cycle; Chromatography, Liquid; Humans; Ions; Mass Spectrometry; Methylation; Mutation; Protein Processing, Post-Translational; Proteomics; Saccharomyces cerevisiae; Tandem Mass Spectrometry

2013
A novel mechanism of formaldehyde neurotoxicity: inhibition of hydrogen sulfide generation by promoting overproduction of nitric oxide.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Animals; Arginine; Blotting, Western; Cystathionine beta-Synthase; Enzyme-Linked Immunosorbent Assay; Formaldehyde; Gene Knockdown Techniques; Gene Silencing; Hydrogen Sulfide; Nitric Oxide; Nitric Oxide Synthase; PC12 Cells; Rats

2013
Transsulfuration pathway thiols and methylated arginines: the Hunter Community Study.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Aging; Amidohydrolases; Arginine; Australia; C-Reactive Protein; Cardiovascular Diseases; Cohort Studies; Community Medicine; Cysteine; Dipeptides; Female; Glutathione; Homocysteine; Humans; Male; Middle Aged; Taurine

2013
Decrease of asymmetric dimethylarginine predicts acute mountain sickness.
    Journal of travel medicine, 2012, Volume: 19, Issue:6

    Topics: Acute Disease; Adult; Altitude Sickness; Arginine; Disease Susceptibility; Echocardiography, Doppler; Enzyme Inhibitors; Humans; Hypoxia; Male; Mountaineering; Nitric Oxide Synthase; Pulmonary Wedge Pressure; Research Design; Risk Assessment; Time Factors

2012
Accelerated fat cell aging links oxidative stress and insulin resistance in adipocytes.
    Journal of biosciences, 2013, Volume: 38, Issue:1

    Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Arginine; Biomarkers; Cell Differentiation; Gene Expression; Glucose; Glucose Oxidase; Hydrogen Peroxide; Insulin Resistance; Interleukin-6; Mice; Oxidative Stress; p21-Activated Kinases; Reactive Oxygen Species; Telomere; Telomere Shortening; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53

2013
Quantification of arginine and dimethylated arginines in human plasma by field-amplified sample injection capillary electrophoresis UV detection.
    Methods in molecular biology (Clifton, N.J.), 2013, Volume: 984

    Topics: Arginine; Buffers; Calibration; Electrophoresis, Capillary; Humans; Ultraviolet Rays

2013
Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma.
    Cancer research, 2013, Feb-15, Volume: 73, Issue:4

    Topics: Adaptor Proteins, Signal Transducing; Arginine; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 4; Extracellular Signal-Regulated MAP Kinases; Female; Gene Amplification; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Liposarcoma; Male; Membrane Proteins; Middle Aged; Neoplasm Grading; Phenylurea Compounds; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-mdm2; Pyrimidines; Receptor, Fibroblast Growth Factor, Type 2; Receptor, Fibroblast Growth Factor, Type 3; Receptor, Fibroblast Growth Factor, Type 4; Receptors, Fibroblast Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction

2013
[Protective effect of insulin-like growth factor-1 on vascular endothelial function in hypercholesterolemia and the underlying mechanism].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2013, Volume: 38, Issue:1

    Topics: Adult; Arginine; Case-Control Studies; Cells, Cultured; Endothelium, Vascular; Female; Human Umbilical Vein Endothelial Cells; Humans; Hypercholesterolemia; Insulin-Like Growth Factor I; Lipoproteins, LDL; Male; Middle Aged; Nitric Oxide; Protective Agents; Vasodilation

2013
Nitric oxide in afferent arterioles after uninephrectomy depends on extracellular L-arginine.
    American journal of physiology. Renal physiology, 2013, Apr-15, Volume: 304, Issue:8

    Topics: Angiotensin II; Animals; Arginine; Arterioles; Blood Pressure; Body Weight; Enzyme Inhibitors; Extracellular Space; Glomerular Filtration Rate; Homeostasis; Male; Nephrectomy; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Rats; Rats, Wistar; Renal Circulation; Vasoconstrictor Agents

2013
Asymmetric dimethylarginine is associated with developmental programming of adult kidney disease and hypertension in offspring of streptozotocin-treated mothers.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Animals; Arginine; Blotting, Western; Electron Spin Resonance Spectroscopy; Female; Hypertension; Kidney Diseases; Pregnancy; Rats; Rats, Sprague-Dawley; Streptozocin

2013
Asymmetric dimethylarginine in exhaled breath condensate and serum of children with asthma.
    Chest, 2013, Volume: 144, Issue:2

    Topics: Adolescent; Arginine; Asthma; Breath Tests; Case-Control Studies; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Exhalation; Female; Humans; Male; Nitric Oxide; Oxidative Stress; Spirometry; Tandem Mass Spectrometry

2013
Asymmetric dimethylarginine (ADMA) and L-arginine levels in children with glycogen storage disease type I.
    Journal of pediatric endocrinology & metabolism : JPEM, 2013, Volume: 26, Issue:5-6

    Topics: Adolescent; Arginine; Child; Child, Preschool; Fatty Acids; Female; Glycogen Storage Disease Type I; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipid Peroxidation; Male

2013
Heat-assisted extraction for the determination of methylarginines in serum by CE.
    Electrophoresis, 2013, Volume: 34, Issue:11

    Topics: Arginine; Cardiovascular Diseases; Electrophoresis, Capillary; Hot Temperature; Humans; omega-N-Methylarginine; Solid Phase Extraction

2013
Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs.
    Scientific reports, 2013, Volume: 3

    Topics: Arginine; Cell Line; Gene Knockdown Techniques; Humans; Methylation; Protein-Arginine N-Methyltransferases; Proteolysis; Repressor Proteins; Substrate Specificity

2013
Effects of salvianolic acid A on plasma and tissue dimethylarginine levels in a rat model of myocardial infarction.
    Journal of cardiovascular pharmacology, 2013, Volume: 61, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Caffeic Acids; Chromatography, High Pressure Liquid; Creatinine; Disease Models, Animal; Heart Ventricles; Kidney; Lactates; Liver; Male; Myocardial Infarction; Proton Pump Inhibitors; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry

2013
Glial-cell-mediated re-induction of the blood-brain barrier phenotype in brain capillary endothelial cells: a differential gel electrophoresis study.
    Proteomics, 2013, Volume: 13, Issue:7

    Topics: Animals; Arginine; Blood-Brain Barrier; Cattle; Culture Media; Electrophoresis, Gel, Two-Dimensional; Endothelial Cells; Immunoblotting; Neuroglia; Phenotype; Rats; Reproducibility of Results

2013
The methylarginines NMMA, ADMA, and SDMA are ubiquitous constituents of the main vegetables of human nutrition.
    Nitric oxide : biology and chemistry, 2013, Apr-01, Volume: 30

    Topics: Arginine; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Vegetables

2013
Association of lipid peroxidation with endothelial dysfunction in patients with overt hypothyroidism.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2013, Volume: 121, Issue:5

    Topics: Adult; Antioxidants; Arginine; Cardiovascular Diseases; Case-Control Studies; Endothelium, Vascular; Female; Humans; Hypothyroidism; Lipid Peroxidation; Male; Malondialdehyde; Nitric Oxide; Risk Factors

2013
Comparison of plasma viscosity as a marker of endothelial dysfunction with nitric oxide and asymmetric dimethylarginine in subjects with dyslipidemia.
    Clinical hemorheology and microcirculation, 2014, Volume: 57, Issue:4

    Topics: Adult; Aged; Arginine; Atherosclerosis; Biomarkers; Blood Viscosity; Dyslipidemias; Endothelium, Vascular; Female; Humans; Lipoproteins, LDL; Male; Middle Aged; Nitric Oxide

2014
Low plasma arginine:asymmetric dimethyl arginine ratios predict mortality after intracranial aneurysm rupture.
    Stroke, 2013, Volume: 44, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Arginine; Biomarkers; Blood Flow Velocity; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Vasospasm, Intracranial

2013
Editorial (hot topic: cardiovascular disease biomarkers: from tradition to modernity).
    Current topics in medicinal chemistry, 2013, Volume: 13, Issue:2

    Topics: Adiponectin; Arginine; Biomarkers; Cardiovascular Diseases; Cystatin C; Endothelins; Glycopeptides; Humans; MicroRNAs; Natriuretic Peptide, Brain; Peptide Fragments; Peroxidase; Predictive Value of Tests; Troponin

2013
Roles of insulin, age, and asymmetric dimethylarginine on nitric oxide synthesis in vivo.
    Diabetes, 2013, Volume: 62, Issue:8

    Topics: Adult; Age Factors; Aged; Arginine; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Humans; Hypercholesterolemia; Hypertension; Insulin; Insulin Resistance; Male; Middle Aged; Nitric Oxide

2013
The value of serum asymmetric dimethylarginine levels for the determination of masked hypertension in patients with diabetes mellitus.
    Atherosclerosis, 2013, Volume: 228, Issue:2

    Topics: Adult; Arginine; Biomarkers; Blood Pressure Monitoring, Ambulatory; Chi-Square Distribution; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Fluorescence; Humans; Hypertension; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Predictive Value of Tests; Prevalence; Risk Factors; Turkey

2013
Asymmetric dimethylarginine levels in children with sickle cell disease and its correlation to tricuspid regurgitant jet velocity.
    European journal of haematology, 2013, Volume: 91, Issue:1

    Topics: Adolescent; Anemia, Sickle Cell; Arginine; Blood Transfusion; Case-Control Studies; Child; Cross-Sectional Studies; Echocardiography, Doppler; Female; Hemolysis; Humans; Hypertension, Pulmonary; Male; Risk Factors; Tricuspid Valve Insufficiency

2013
A synthetic receptor for asymmetric dimethyl arginine.
    Journal of the American Chemical Society, 2013, May-01, Volume: 135, Issue:17

    Topics: Arginine; Chromatography, High Pressure Liquid; Combinatorial Chemistry Techniques; Crystallography, X-Ray; Magnetic Resonance Spectroscopy; Methylation; Models, Molecular; Protein Binding; Protein Processing, Post-Translational; Receptors, Drug; Small Molecule Libraries

2013
Influence of ezetimibe on ADMA-DDAH-NO pathway in rat liver subjected to partial ischemia followed by global reperfusion.
    Pharmacological reports : PR, 2013, Volume: 65, Issue:1

    Topics: Amidohydrolases; Animals; Anticholesteremic Agents; Arginine; Azetidines; Ezetimibe; Liver; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reperfusion Injury; RNA, Messenger; Time Factors

2013
Effect of cyclophosphamide and morin-5'-sulfonic acid sodium salt, alone or in combination, on ADMA/DDAH pathway in rats.
    Pharmacological reports : PR, 2013, Volume: 65, Issue:1

    Topics: Amidohydrolases; Animals; Antioxidants; Arginine; Cyclophosphamide; Drug Therapy, Combination; Female; Flavonoids; Immunosuppressive Agents; Liver; Male; Rats; Rats, Wistar; Sulfonic Acids

2013
Asymmetric dimethylarginine predicts decline of glucose tolerance in men with stable coronary artery disease: a 4.5-year follow-up study.
    Cardiovascular diabetology, 2013, Volume: 12

    Topics: Adult; Aged; Angina, Stable; Arginine; Diabetes Mellitus, Type 2; Follow-Up Studies; Glucose Intolerance; Glucose Tolerance Test; Humans; Male; Middle Aged; Prediabetic State; Prognosis; Proportional Hazards Models; Risk Factors

2013
Up-regulation of protein tyrosine nitration in methamphetamine-induced neurotoxicity through DDAH/ADMA/NOS pathway.
    Neurochemistry international, 2013, Volume: 62, Issue:8

    Topics: Amidohydrolases; Animals; Arginine; Base Sequence; Brain; DNA Primers; Male; Methamphetamine; Nitrates; Nitric Oxide Synthase; PC12 Cells; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine; Up-Regulation

2013
Impact of high salt independent of blood pressure on PRMT/ADMA/DDAH pathway in the aorta of Dahl salt-sensitive rats.
    International journal of molecular sciences, 2013, Apr-12, Volume: 14, Issue:4

    Topics: Amidohydrolases; Animals; Antihypertensive Agents; Aorta; Arginine; Blood Pressure; Hydralazine; Hypertension; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Protein-Arginine N-Methyltransferases; Rats; Rats, Inbred Dahl; RNA, Messenger; Signal Transduction; Sodium Chloride, Dietary

2013
Asymmetric dimethylarginine predicts survival in the elderly.
    Age (Dordrecht, Netherlands), 2013, Volume: 35, Issue:6

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Cardiovascular Diseases; Cause of Death; Chromatography, Liquid; Female; Follow-Up Studies; Humans; Italy; Male; Population Surveillance; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Factors; Tandem Mass Spectrometry; Time Factors

2013
Monitorization of asymmetric dimethylarginine (ADMA) levels in an experimental ischemia-reperfusion flap model: a preliminary report.
    Journal of reconstructive microsurgery, 2013, Volume: 29, Issue:6

    Topics: Abdominal Muscles; Animals; Arginine; Disease Models, Animal; Graft Rejection; Graft Survival; Male; Monitoring, Physiologic; Nitric Oxide; Nitric Oxide Synthase; Postoperative Period; Preoperative Period; Random Allocation; Rats; Rats, Wistar; Reference Values; Reperfusion Injury; Risk Factors; Skin Transplantation; Statistics, Nonparametric; Surgical Flaps

2013
Sex differences of oxidative stress to cholestatic liver and kidney injury in young rats.
    Pediatrics and neonatology, 2013, Volume: 54, Issue:2

    Topics: Animals; Arginine; Cationic Amino Acid Transporter 1; Cationic Amino Acid Transporter 2; Cholestasis; Female; Kidney; Liver; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sex Characteristics

2013
Endothelial dysfunction, inflammation and malnutrition markers as predictors of mortality in dialysis patients: multimarker approach.
    International urology and nephrology, 2013, Volume: 45, Issue:6

    Topics: Adult; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Inflammation; Kaplan-Meier Estimate; Kidney Failure, Chronic; Male; Malnutrition; Middle Aged; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Renal Dialysis; Risk Assessment; ROC Curve; Serum Albumin; Serum Amyloid A Protein

2013
The usefulness of plasma asymmetric dimethylarginine (ADMA) levels and tissue doppler echocardiography for heart function in term infants born to mothers with gestational diabetes mellitus.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2013, Volume: 26, Issue:17

    Topics: Arginine; Case-Control Studies; Diabetes, Gestational; Echocardiography, Doppler; Female; Heart; Humans; Infant, Newborn; Male; Mothers; Predictive Value of Tests; Pregnancy; Term Birth; Ventricular Function, Left

2013
Nonstenotic bicuspid aortic valve is associated with elevated plasma asymmetric dimethylarginine.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2013, Volume: 14, Issue:6

    Topics: Adult; Aorta; Aortic Aneurysm; Aortic Valve; Arginine; Bicuspid Aortic Valve Disease; Biomarkers; Case-Control Studies; Dilatation, Pathologic; Female; Heart Valve Diseases; Homocysteine; Humans; Linear Models; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Multivariate Analysis; Prognosis; Risk Factors; Up-Regulation; Vascular Stiffness; Young Adult

2013
Involvement of DDAH/ADMA pathway in the pathogenesis of rheumatoid arthritis in rats.
    International immunopharmacology, 2013, Volume: 16, Issue:2

    Topics: Amidohydrolases; Animals; Ankle Joint; Arginine; Arthritis, Experimental; Arthritis, Rheumatoid; Cytokines; Male; Neuropeptides; Rats; Rats, Sprague-Dawley; Synovial Membrane

2013
Asymmetric dimethylarginine and asthma: results from the Childhood Asthma Prevention Study.
    The European respiratory journal, 2013, Volume: 41, Issue:5

    Topics: Arginine; Asthma; Australia; Child; Cohort Studies; Cross-Sectional Studies; Female; Humans; Inflammation; Male; Randomized Controlled Trials as Topic; Respiratory Function Tests; Risk Factors

2013
Effects of losartan and pentoxifylline on renal dimethylarginine dimethylaminohydrolase-1 expression in proteinuric nephropathy.
    American journal of nephrology, 2013, Volume: 37, Issue:5

    Topics: Acetylglucosaminidase; Albuminuria; Amidohydrolases; Angiotensin II Type 1 Receptor Blockers; Animals; Arginine; Cell Line; Free Radical Scavengers; Kidney Tubules, Proximal; Losartan; Oxidative Stress; Pentoxifylline; Rats; Reactive Oxygen Species

2013
Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia.
    American journal of respiratory cell and molecular biology, 2013, Volume: 49, Issue:3

    Topics: Amidohydrolases; Animals; Arginine; Blood Vessels; Cyclic GMP; Gene Expression; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Lung; Mice; Nitric Oxide; Nitroarginine; Organ Culture Techniques; Oxadiazoles; Signal Transduction; Vasoconstriction

2013
Elevated circulating levels and tissue expression of pentraxin 3 in uremia: a reflection of endothelial dysfunction.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Adult; Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Endothelium; Female; Gene Expression; Humans; Kidney; Male; Middle Aged; Prognosis; Renal Insufficiency, Chronic; RNA, Messenger; Serum Amyloid P-Component; Subcutaneous Fat, Abdominal; Uremia; Vascular Resistance

2013
High plasma concentrations of asymmetric dimethylarginine inhibit ischemic cardioprotection in hypercholesterolemic rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2013, Volume: 46, Issue:5

    Topics: Animals; Arginine; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Hypercholesterolemia; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Rats; Rats, Wistar

2013
Increased symmetrical dimethylarginine in ischemic acute kidney injury as a causative factor of renal L-arginine deficiency.
    Translational research : the journal of laboratory and clinical medicine, 2013, Volume: 162, Issue:2

    Topics: Acute Kidney Injury; Amidohydrolases; Animals; Arginine; Blotting, Western; Chromatography, High Pressure Liquid; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Intracellular Signaling Peptides and Proteins; Kidney; Kidney Function Tests; Protein-Arginine N-Methyltransferases; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Tandem Mass Spectrometry

2013
Elevated levels of asymmetric dimethylarginine are associated with lower CD4+ count and higher viral load in HIV-infected individuals.
    Atherosclerosis, 2013, Volume: 229, Issue:1

    Topics: Adult; Arginine; Biomarkers; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Endothelium, Vascular; Female; HIV Infections; Humans; Hypertension; Male; Middle Aged; Multivariate Analysis; Nitric Oxide; Predictive Value of Tests; Risk Factors; Viral Load

2013
4-HNE increases intracellular ADMA levels in cultured HUVECs: evidence for miR-21-dependent mechanisms.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Aldehydes; Amidohydrolases; Arginine; Base Sequence; Blotting, Western; Cells, Cultured; DNA Primers; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Humans; MicroRNAs; Real-Time Polymerase Chain Reaction; RNA, Messenger

2013
A comparison of maternal serum levels of endothelial nitric oxide synthase, asymmetric dimethylarginine, and homocysteine in normal and preeclamptic pregnancies.
    Medical science monitor : international medical journal of experimental and clinical research, 2013, Jun-05, Volume: 19

    Topics: Adult; Arginine; Case-Control Studies; Female; Homocysteine; Humans; Nitric Oxide Synthase Type III; Pre-Eclampsia; Pregnancy

2013
Carotid intima-media thickness and plasma asymmetric dimethylarginine in Mexican children exposed to inorganic arsenic.
    Environmental health perspectives, 2013, Volume: 121, Issue:9

    Topics: Adolescent; Arginine; Arsenic; Atherosclerosis; Biomarkers; Carotid Intima-Media Thickness; Child; Child, Preschool; Cross-Sectional Studies; Environmental Exposure; Enzyme-Linked Immunosorbent Assay; Humans; Linear Models; Mexico; Tunica Intima; Tunica Media; Vascular Cell Adhesion Molecule-1

2013
Involvement of advanced glycation end product-induced asymmetric dimethylarginine generation in endothelial dysfunction.
    Diabetes & vascular disease research, 2013, Volume: 10, Issue:5

    Topics: Aged; Amidohydrolases; Arginine; Atherosclerosis; Cells, Cultured; Diabetic Nephropathies; Endothelial Cells; Female; Glycation End Products, Advanced; Humans; Male; Middle Aged; Nitric Oxide; Reactive Oxygen Species; Vascular Diseases

2013
Reactive metabolites and AGE-RAGE-mediated inflammation in patients following liver transplantation.
    Mediators of inflammation, 2013, Volume: 2013

    Topics: Antioxidants; Arginine; Female; Glycation End Products, Advanced; Humans; Inflammation; Liver Transplantation; Male; Models, Biological; Pyruvaldehyde; Receptor for Advanced Glycation End Products; Receptors, Immunologic

2013
L-arginine metabolism in early-onset and late-onset pre-eclamptic pregnancies.
    Scandinavian journal of clinical and laboratory investigation, 2013, Volume: 73, Issue:5

    Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Female; Fetal Blood; Humans; omega-N-Methylarginine; Ornithine; Pre-Eclampsia; Pregnancy; Young Adult

2013
Endothelial function in patients with metabolic syndrome and erectile dysfunction: a question of angiopoietin imbalance?
    Andrology, 2013, Volume: 1, Issue:4

    Topics: Angiopoietin-1; Angiopoietin-2; Angiopoietins; Arginine; Biomarkers; Cross-Sectional Studies; Endothelium, Vascular; Hemodynamics; Humans; Impotence, Vasculogenic; Male; Manometry; Metabolic Syndrome; Middle Aged; Obesity, Abdominal; Penile Erection; Penis; Predictive Value of Tests; Severity of Illness Index; Surveys and Questionnaires; Ultrasonography, Doppler, Duplex

2013
Comparison of transesophageal echocardiographic analysis and circulating biomarker expression profile in calcific aortic valve disease.
    The Journal of heart valve disease, 2013, Volume: 22, Issue:2

    Topics: Aged; Aged, 80 and over; alpha-2-HS-Glycoprotein; Aortic Valve; Aortic Valve Stenosis; Arginine; Biomarkers; Calcinosis; Case-Control Studies; Echocardiography, Transesophageal; Female; Humans; Male; Natriuretic Peptide, Brain; Osteopontin; Parathyroid Hormone; Peptide Fragments; Sclerosis; Severity of Illness Index

2013
Effect of metabolic abnormalities on endothelial dysfunction in normotensive offspring of subject with hypertension.
    International angiology : a journal of the International Union of Angiology, 2013, Volume: 32, Issue:4

    Topics: Adiponectin; Adult; Arginine; Biomarkers; Brachial Artery; Case-Control Studies; Disease Progression; Female; Genetic Predisposition to Disease; Heredity; Humans; Hyperemia; Hyperinsulinism; Hypertension; Insulin; Insulin Resistance; Linear Models; Male; Multivariate Analysis; Pedigree; Phenotype; Risk Factors; Ultrasonography; Vasodilation

2013
Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine.
    Circulation, 2013, Aug-20, Volume: 128, Issue:8

    Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Cardiovascular Diseases; Cells, Cultured; Disease Models, Animal; Endothelium, Vascular; Esomeprazole; Gastroesophageal Reflux; Humans; Lansoprazole; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type III; Proton Pump Inhibitors; Risk Factors; Vasodilation

2013
Abdominal obesity is associated with peripheral artery disease in hemodialysis patients.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Adiponectin; Ankle Brachial Index; Arginine; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Interleukin-6; Lipid Metabolism; Male; Middle Aged; Obesity, Abdominal; Peripheral Arterial Disease; Renal Dialysis; Risk Factors

2013
Portal vein omentin is increased in patients with liver cirrhosis but is not associated with complications of portal hypertension.
    European journal of clinical investigation, 2013, Volume: 43, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Ascites; Case-Control Studies; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; GPI-Linked Proteins; Humans; Hypertension, Portal; Kidney; Kidney Function Tests; Lectins; Liver; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Portal Vein; Portasystemic Shunt, Surgical; Varicose Veins

2013
Assessment of L-arginine asymmetric 1 dimethyl (ADMA) in early-onset and late-onset (severe) preeclampsia.
    Nitric oxide : biology and chemistry, 2013, Sep-01, Volume: 33

    Topics: Arginine; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Nitric Oxide; Pre-Eclampsia; Pregnancy

2013
Effect of ethinyl estradiol-cyproterone acetate treatment on asymmetric dimethyl-arginine levels in women with polycystic ovary syndrome.
    Archives of gynecology and obstetrics, 2014, Volume: 289, Issue:1

    Topics: Adult; Androgen Antagonists; Arginine; Cholesterol, LDL; Cyproterone Acetate; Drug Combinations; Ethinyl Estradiol; Female; Glucose; Humans; Insulin Resistance; Lipid Metabolism; Polycystic Ovary Syndrome; Prospective Studies; Young Adult

2014
ON NO--the continuing story of nitric oxide, diabetes, and cardiovascular disease.
    Diabetes, 2013, Volume: 62, Issue:8

    Topics: Arginine; Diabetes Mellitus, Type 2; Humans; Insulin; Insulin Resistance; Male; Nitric Oxide

2013
Plasma concentrations of arginine and asymmetric dimethylarginine do not reflect their intracellular concentrations in peripheral blood mononuclear cells.
    Metabolism: clinical and experimental, 2013, Volume: 62, Issue:10

    Topics: Arginine; Biomarkers; Homoarginine; Humans; Leukocytes, Mononuclear; Nitric Oxide

2013
Genetic variation in the dimethylarginine dimethylaminohydrolase 1 gene (DDAH1) is related to asymmetric dimethylarginine (ADMA) levels, but not to endothelium-dependent vasodilation.
    Vascular medicine (London, England), 2013, Volume: 18, Issue:4

    Topics: Age Factors; Aged; Amidohydrolases; Arginine; Brachial Artery; Chromatography, High Pressure Liquid; Endothelium, Vascular; Female; Genotype; Humans; Isoenzymes; Male; Phenotype; Polymorphism, Single Nucleotide; Prospective Studies; Sweden; Ultrasonography; Vasodilation

2013
Asymmetric dimethylarginine: a disease marker for asthma?
    Chest, 2013, Volume: 144, Issue:2

    Topics: Arginine; Asthma; Female; Humans; Male

2013
Serum methylarginines and incident depression in a cohort of older adults.
    Journal of affective disorders, 2013, Volume: 151, Issue:2

    Topics: Aged; Aged, 80 and over; Arginine; Depression; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; New South Wales; Nitric Oxide Synthase

2013
Serum endothelin-1 and NT-proBNP, but not ADMA, endoglin and TIMP-1 levels, reflect impaired right ventricular function in patients with systemic sclerosis.
    Clinical rheumatology, 2014, Volume: 33, Issue:1

    Topics: Adult; Aged; Antigens, CD; Arginine; Biomarkers; Case-Control Studies; Collagen; Echocardiography; Echocardiography, Doppler; Endoglin; Endothelin-1; Endothelium, Vascular; Female; Fibrosis; Humans; Lung Diseases; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Prospective Studies; Receptors, Cell Surface; Scleroderma, Systemic; Tissue Inhibitor of Metalloproteinase-1; Ventricular Function, Right

2014
Plasma asymmetric dimethylarginine and adverse events in patients with atrial fibrillation referred for coronary angiogram.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Aged; Aged, 80 and over; Arginine; Atrial Fibrillation; Cardiovascular Diseases; Coronary Angiography; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Multivariate Analysis; Predictive Value of Tests; Proportional Hazards Models; Referral and Consultation; Risk Assessment; Risk Factors; Stroke; Survival Rate; Time Factors

2013
Elevated asymmetric dimethylarginine levels predict short- and long-term mortality risk in critically ill patients.
    Journal of critical care, 2013, Volume: 28, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Case-Control Studies; Critical Illness; Female; Humans; Intensive Care Units; Male; Middle Aged; Multiple Organ Failure; Predictive Value of Tests; Prognosis; Prospective Studies; Risk Factors; Sepsis; Severity of Illness Index; Survival Rate

2013
Endothelial cell transfusion ameliorates endothelial dysfunction in 5/6 nephrectomized rats.
    American journal of physiology. Heart and circulatory physiology, 2013, Oct-15, Volume: 305, Issue:8

    Topics: Acetylcholine; Amidohydrolases; Animals; Aorta; Arginine; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Male; Mesenteric Arteries; Myography; Nephrectomy; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Vasodilation; Vasodilator Agents

2013
Enhanced levels of asymmetric dimethylarginine in a serum of middle age patients with myelodysplastic syndrome.
    Journal of hematology & oncology, 2013, Aug-19, Volume: 6

    Topics: Adult; Arginine; Case-Control Studies; Female; Humans; Male; Middle Aged; Myelodysplastic Syndromes; Oxidative Stress

2013
Association between endothelial dysfunction and frailty: the Toledo Study for Healthy Aging.
    Age (Dordrecht, Netherlands), 2014, Volume: 36, Issue:1

    Topics: Aged; Arginine; Atherosclerosis; Biomarkers; Comorbidity; Demography; Female; Frail Elderly; Geriatric Assessment; Humans; Longitudinal Studies; Male; Middle Aged; Prospective Studies; Risk Factors; Sex Factors; Spain

2014
Effects of acute and chronic stress on the L-arginine nitric oxide pathway in black and white South Africans: the sympathetic activity and ambulatory blood pressure in Africans study.
    Psychosomatic medicine, 2013, Volume: 75, Issue:8

    Topics: Acute Disease; Adult; Arginine; Black People; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cardiovascular Diseases; Chronic Disease; Cold Temperature; Cross-Sectional Studies; Disease Susceptibility; Female; Hemodynamics; Humans; Male; Middle Aged; Motor Activity; Nitric Oxide; Pressure; Rest; South Africa; Stress, Psychological; Stroop Test; White People

2013
High asymmetric dimethylarginine (ADMA) levels in patients with brucellosis.
    Inflammation, 2014, Volume: 37, Issue:1

    Topics: Adult; Arginine; Brucella; Brucellosis; Female; Humans; Male; Nitric Oxide; Nitric Oxide Synthase; ROC Curve; Vasculitis

2014
Apelin-13 deteriorates hypertension in rats after damage of the vascular endothelium by ADMA.
    Canadian journal of physiology and pharmacology, 2013, Volume: 91, Issue:9

    Topics: Animals; Arginine; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Endothelium, Vascular; Hypertension; Injections, Intravenous; Intercellular Signaling Peptides and Proteins; Male; Myosin Light Chains; Nitric Oxide; Phosphorylation; Rats; Rats, Sprague-Dawley; Time Factors; Vasoconstriction; Vasodilation; von Willebrand Factor

2013
Asymmetric dimethylarginine (ADMA) and soluble vascular cell adhesion molecule 1(sVCAM-1) as circulating markers for endothelial dysfunction in patients with pheochromocytoma.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2013, Volume: 121, Issue:9

    Topics: Adrenal Gland Neoplasms; Adult; Aged; Arginine; Biomarkers; Blood Glucose; Blood Pressure; Catecholamines; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypertension; Lipids; Male; Middle Aged; Pheochromocytoma; Vascular Cell Adhesion Molecule-1; Vascular Diseases

2013
Symmetrical dimethylarginine predicts mortality in the general population: observations from the Dallas heart study.
    Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:11

    Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Female; Follow-Up Studies; Humans; Male; Middle Aged; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Risk Factors; Texas

2013
Urinary NGAL and hematic ADMA levels: an early sign of cardio-renal syndrome in young adults born preterm?
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2013, Volume: 26 Suppl 2

    Topics: Acute-Phase Proteins; Adolescent; Adult; Adult Children; Arginine; Cardio-Renal Syndrome; Case-Control Studies; Female; Humans; Infant, Newborn; Infant, Premature; Lipocalin-2; Lipocalins; Male; Pregnancy; Premature Birth; Prognosis; Proto-Oncogene Proteins; Young Adult

2013
Structure and function of large arteries in hypertension in relation to oxidative stress markers.
    Kardiologia polska, 2013, Volume: 71, Issue:9

    Topics: Adult; Advanced Oxidation Protein Products; Arginine; Arteries; Biomarkers; Carotid Arteries; Carotid Intima-Media Thickness; Female; Humans; Hypertension; Lipoproteins, LDL; Male; Middle Aged; Multivariate Analysis; Oxidative Stress; Pulse Wave Analysis; Vascular Stiffness

2013
Impaired endothelial function after aneurysmal subarachnoid haemorrhage correlates with arginine:asymmetric dimethylarginine ratio.
    British journal of anaesthesia, 2014, Volume: 112, Issue:2

    Topics: Adult; Arginine; Biomarkers; Blood Flow Velocity; Endothelium; Female; Follow-Up Studies; Humans; Hyperemia; Male; Middle Aged; Prospective Studies; Subarachnoid Hemorrhage; Survival Analysis; Vasospasm, Intracranial

2014
The role of profilin-1 in endothelial cell injury induced by advanced glycation end products (AGEs).
    Cardiovascular diabetology, 2013, Oct-04, Volume: 12

    Topics: Antioxidants; Arginine; Cells, Cultured; Cytoskeleton; Dose-Response Relationship, Drug; Glycation End Products, Advanced; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; NF-kappa B; Nitric Oxide; Profilins; Protein Kinase C; Protein Kinase Inhibitors; Reactive Oxygen Species; RNA Interference; RNA, Messenger; Signal Transduction; Time Factors; Transfection

2013
Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway.
    Cell death & disease, 2013, Oct-03, Volume: 4

    Topics: Aged; Antibodies, Monoclonal; Apoptosis; Arginine; Case-Control Studies; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Culture Media, Serum-Free; Doxorubicin; Enzyme Activation; fas Receptor; Female; Fibroblasts; Humans; JNK Mitogen-Activated Protein Kinases; Male; Middle Aged; Signal Transduction; Sphingosine

2013
Simultaneous determination of homocysteine and asymmetric dimethylarginine in human urine by liquid chromatography-tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, Nov-15, Volume: 939

    Topics: Arginine; Biomarkers; Chromatography, Liquid; Coronary Artery Disease; Homocysteine; Humans; Limit of Detection; Linear Models; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2013
Gender differences in oxidative and nitrosative stress parameters in kidney transplant patients on tacrolimus-based immunosuppression.
    International urology and nephrology, 2014, Volume: 46, Issue:6

    Topics: Adult; Advanced Oxidation Protein Products; Arginine; Catalase; Female; Healthy Volunteers; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Mycophenolic Acid; Nitrates; Nitrites; Oxidative Stress; Prednisone; Sex Factors; Sulfhydryl Compounds; Tacrolimus; Thiobarbituric Acid Reactive Substances

2014
Differential associations of angiographic extent and severity of coronary artery disease with asymmetric dimethylarginine but not insulin resistance in non-diabetic men with stable angina: a cross-sectional study.
    Cardiovascular diabetology, 2013, Oct-09, Volume: 12

    Topics: Adult; Aged; Angina, Stable; Arginine; Biomarkers; Blood Glucose; Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studies; Humans; Insulin; Insulin Resistance; Linear Models; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Risk Factors; Severity of Illness Index

2013
Asymmetric dimethylarginine accumulates in the kidney during ischemia/reperfusion injury.
    Kidney international, 2014, Volume: 85, Issue:3

    Topics: Acetylcysteine; Amidohydrolases; Animals; Arginine; Kidney; Male; Mice, Inbred C57BL; Nitric Oxide Synthase Type III; Oxidative Stress; Reperfusion Injury

2014
Soluble TWEAK plasma levels increase after renal transplantation and associate with the improvement of endothelial function.
    European journal of clinical investigation, 2013, Volume: 43, Issue:12

    Topics: Adult; Arginine; Biomarkers; Brachial Artery; C-Reactive Protein; Cytokine TWEAK; Endothelium, Vascular; Female; Humans; Kidney Transplantation; Male; Postoperative Period; Prospective Studies; Renal Insufficiency, Chronic; Tumor Necrosis Factors; Vascular Diseases; Vasodilation

2013
Two different approaches to restore renal nitric oxide and prevent hypertension in young spontaneously hypertensive rats: l-citrulline and nitrate.
    Translational research : the journal of laboratory and clinical medicine, 2014, Volume: 163, Issue:1

    Topics: Animals; Arginine; Citrulline; Dietary Supplements; Hypertension; Male; Nitrates; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY

2014
Determination of homoarginine, arginine, NMMA, ADMA, and SDMA in biological samples by HPLC-ESI-mass spectrometry.
    International journal of molecular sciences, 2013, Oct-09, Volume: 14, Issue:10

    Topics: Arginine; Chromatography, High Pressure Liquid; Homoarginine; Humans; Tandem Mass Spectrometry

2013
A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with chronic kidney disease.
    Atherosclerosis, 2013, Volume: 231, Issue:1

    Topics: Adult; Aged; Alleles; Amidohydrolases; Arginine; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Renal Insufficiency, Chronic; White People

2013
Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury.
    American journal of respiratory cell and molecular biology, 2014, Volume: 50, Issue:3

    Topics: Acute Lung Injury; Amidohydrolases; Animals; Arginine; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Genetic Therapy; Humans; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Microvessels; Oxidative Stress; Peroxynitrous Acid; Pulmonary Edema; Superoxides; Time Factors; Transfection; Up-Regulation

2014
The cardiovascular risk marker asymmetric dimethylarginine is elevated in asymptomatic, untreated HIV-1 infection and correlates with markers of immune activation and disease progression.
    Annals of clinical biochemistry, 2014, Volume: 51, Issue:Pt 5

    Topics: Adenosine Deaminase; Adult; Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; Cross-Sectional Studies; Female; HIV Infections; HIV Seropositivity; Humans; Immunoglobulin G; Interleukin-6; Male; Viral Load

2014
Memory impairment is associated with serum methylarginines in older adults.
    Current Alzheimer research, 2014, Volume: 11, Issue:1

    Topics: Aged; Aged, 80 and over; Arginine; Atrial Fibrillation; Cohort Studies; Diabetes Mellitus; Educational Status; Female; Humans; Logistic Models; Male; Memory Disorders; Middle Aged; Multivariate Analysis; Neuropsychological Tests; Odds Ratio; Severity of Illness Index

2014
Increased serum asymmetric dimethylarginine level is an independent predictor of contrast-induced nephropathy.
    Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2013, Volume: 41, Issue:7

    Topics: Aged; Angina Pectoris; Arginine; Contrast Media; Coronary Angiography; Creatinine; Female; Humans; Kidney Diseases; Male; Middle Aged; Predictive Value of Tests; ROC Curve

2013
Genetic and environmental determinants of dimethylarginines and association with cardiovascular disease in patients with type 2 diabetes.
    Diabetes care, 2014, Volume: 37, Issue:3

    Topics: Aged; Arginine; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Environment; Female; Genotype; Humans; Intermittent Claudication; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors

2014
Effect of therapeutic inhibition of TNF on circulating endothelial progenitor cells in patients with rheumatoid arthritis.
    Mediators of inflammation, 2013, Volume: 2013

    Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal, Humanized; Antigens, CD34; Arginine; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Etanercept; Female; Flow Cytometry; Humans; Immunoglobulin G; Inflammation; Leukocytes, Mononuclear; Male; Middle Aged; Receptors, Tumor Necrosis Factor; Stem Cells; Tumor Necrosis Factor-alpha; Ultrasonography, Doppler; Vascular Endothelial Growth Factor Receptor-2

2013
Severe pulmonary embolism decreases plasma L-arginine.
    The European respiratory journal, 2014, Volume: 43, Issue:3

    Topics: Arginase; Arginine; Chromatography, High Pressure Liquid; Echocardiography, Doppler; Hemolysis; Humans; Hypertension, Pulmonary; Prospective Studies; Pulmonary Embolism; Tricuspid Valve; Tricuspid Valve Insufficiency

2014
Renoprotective effects of melatonin in young spontaneously hypertensive rats with L-NAME.
    Pediatrics and neonatology, 2014, Volume: 55, Issue:3

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Amidohydrolases; Animals; Antioxidants; Arginine; Blood Pressure; Deoxyguanosine; Humans; Hypertension; Hypertension, Renal; Kidney; Male; Melatonin; Nephritis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR

2014
L-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in plasma and synovial fluid of patients with knee osteoarthritis.
    Medical science monitor : international medical journal of experimental and clinical research, 2013, Nov-26, Volume: 19

    Topics: Arginine; Case-Control Studies; Humans; Nitric Oxide; Osteoarthritis, Knee; Signal Transduction; Synovial Fluid; Thiobarbituric Acid Reactive Substances

2013
Markers of endothelial dysfunction and evaluation of vascular reactivity tests in Behçet disease.
    Angiology, 2014, Volume: 65, Issue:10

    Topics: Adult; Arginine; Behcet Syndrome; Biomarkers; Blood Sedimentation; Case-Control Studies; Endothelium, Vascular; Female; Homocysteine; Humans; Lipids; Male; Middle Aged; Prospective Studies; Ultrasonography; Vasodilation

2014
Lipoprotein apheresis reduces biomarkers of plaque destabilization and cardiovascular risk.
    Journal of clinical apheresis, 2014, Volume: 29, Issue:5

    Topics: Adult; Aged; Arginine; Biomarkers; Blood Component Removal; C-Reactive Protein; Cardiovascular Diseases; Female; Humans; Lipoproteins; Male; Matrix Metalloproteinase 9; Middle Aged; Plaque, Atherosclerotic; Pregnancy-Associated Plasma Protein-A; Vascular Cell Adhesion Molecule-1

2014
Modulation of arginine and asymmetric dimethylarginine concentrations in liver and plasma by exogenous hydrogen sulfide in LPS-induced endotoxemia.
    Canadian journal of physiology and pharmacology, 2013, Volume: 91, Issue:12

    Topics: Alanine Transaminase; Amidohydrolases; Animals; Arginase; Arginine; Aspartate Aminotransferases; Endotoxemia; Hydrogen Sulfide; Hypoxia-Inducible Factor 1, alpha Subunit; Lipopolysaccharides; Liver; Male; Peroxidase; Rats; Rats, Wistar

2013
Asymmetric dimethylarginine and augmentation index in newly diagnosed patients with hypertension.
    Angiology, 2015, Volume: 66, Issue:1

    Topics: Adult; Age Factors; Alcohol Drinking; Aorta; Arginine; Arterial Pressure; Biomarkers; C-Reactive Protein; Female; Humans; Hypertension; Inflammation Mediators; Male; Middle Aged; Predictive Value of Tests; Pulse Wave Analysis; Risk Factors; Sex Factors; Smoking; Vascular Stiffness

2015
Asymmetric dimethylarginine blocks nitric oxide-mediated alcohol-stimulated cilia beating.
    Mediators of inflammation, 2013, Volume: 2013

    Topics: Amidohydrolases; Animals; Arginine; Bronchi; Cattle; Cell Survival; Cells, Cultured; Cilia; Cyclic AMP-Dependent Protein Kinases; Epithelial Cells; Ethanol; Lung; Lung Diseases; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Time Factors; Trachea

2013
Relationship between serum paraoxonase and homocysteine thiolactonase activity, adipokines, and asymmetric dimethyl arginine concentrations in renal transplant patients.
    Transplantation proceedings, 2013, Volume: 45, Issue:10

    Topics: Adipokines; Adult; Aged; Arginine; Aryldialkylphosphatase; Atherosclerosis; Biomarkers; C-Reactive Protein; Carboxylic Ester Hydrolases; Case-Control Studies; Colorimetry; Enzyme-Linked Immunosorbent Assay; Female; Humans; Kidney Transplantation; Lipids; Male; Middle Aged; Predictive Value of Tests; Renal Dialysis; Renal Insufficiency; Risk Factors; Spectrophotometry; Treatment Outcome

2013
Clinical metabolomics and hematic ADMA predict the future onset of cardiorenal syndrome in young grown-up subjects who were born preterm.
    Clinical biochemistry, 2014, Volume: 47, Issue:6

    Topics: Adult; Arginine; Cardio-Renal Syndrome; Case-Control Studies; Discriminant Analysis; Female; Gestational Age; Humans; Infant, Extremely Low Birth Weight; Infant, Newborn; Least-Squares Analysis; Male; Metabolomics; Premature Birth; Young Adult

2014
Predictive value of plasma asymmetric dimethylarginine, homocysteine, and high-sensitive CRP levels in occult coronary artery disease: A multidetector-row computed tomography study.
    Herz, 2015, Volume: 40, Issue:3

    Topics: Arginine; Biomarkers; C-Reactive Protein; Coronary Artery Disease; Female; Homocysteine; Humans; Male; Middle Aged; Multidetector Computed Tomography; Prognosis; Reproducibility of Results; Risk Assessment; Sensitivity and Specificity

2015
Platelet content of nitric oxide synthase 3 phosphorylated at Serine 1177 is associated with the functional response of platelets to aspirin.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: Aged; Arginine; Aspirin; Blood Platelets; Blotting, Western; Collagen; Erythrocytes; Female; Flow Cytometry; Humans; Leukocytes; Light; Male; Mutation; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Phosphorylation; Phosphoserine

2013
Asymmetric dimethylarginine is related to the predicted stroke risk in middle-aged Japanese men.
    Journal of the neurological sciences, 2014, Mar-15, Volume: 338, Issue:1-2

    Topics: Adult; Aged; Arginine; Humans; Linear Models; Male; Middle Aged; Retrospective Studies; Risk Factors; Stroke; Surveys and Questionnaires; Young Adult

2014
ADMA levels and arginine/ADMA ratios reflect severity of disease and extent of inflammation after subarachnoid hemorrhage.
    Neurocritical care, 2014, Volume: 21, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; C-Reactive Protein; Cytokines; Female; Humans; Inflammation; Male; Middle Aged; Severity of Illness Index; Subarachnoid Hemorrhage

2014
[Effect of crucumin on vascular endothelial function in atherosclerotic rabbits].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2013, Volume: 38, Issue:19

    Topics: Animals; Arginine; Atherosclerosis; Curcumin; Endothelium, Vascular; Male; Nitric Oxide Synthase; Rabbits

2013
I. Peripheral endothelial dysfunction after subarachnoid haemorrhage: what the fingertips can tell us.
    British journal of anaesthesia, 2014, Volume: 112, Issue:2

    Topics: Arginine; Endothelium; Female; Humans; Male; Subarachnoid Hemorrhage

2014
Asymmetric dimethylarginine is not associated with subendocardial viability ratio in Rheumatoid Arthritis.
    International journal of cardiology, 2014, Mar-01, Volume: 172, Issue:1

    Topics: Aged; Arginine; Arthritis, Rheumatoid; Cardiovascular Diseases; Endocardium; Female; Humans; Male; Middle Aged; Risk Assessment

2014
The effects of acute intermittent hypoxia on cardiovascular parameters in normotensive and chronic hypobaric hypoxia-induced hypertensive rabbits.
    General physiology and biophysics, 2014, Volume: 33, Issue:2

    Topics: Air Pressure; Animals; Arginine; Blood Pressure; Cardiovascular System; Endothelin-1; Hematocrit; Hypertension; Nitric Oxide Synthase Type III; Norepinephrine; Oxygen; Rabbits; Time Factors

2014
The inhibitory effect of quercetin on asymmetric dimethylarginine-induced apoptosis is mediated by the endoplasmic reticulum stress pathway in glomerular endothelial cells.
    International journal of molecular sciences, 2014, Jan-02, Volume: 15, Issue:1

    Topics: Apoptosis; Arginine; Cells, Cultured; eIF-2 Kinase; Endoplasmic Reticulum Stress; Endoribonucleases; Endothelial Cells; Humans; JNK Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Quercetin; RNA Interference; RNA, Small Interfering; Signal Transduction; Transcription Factor CHOP; Transforming Growth Factor beta

2014
N-acetylcysteine prevents hypertension via regulation of the ADMA-DDAH pathway in young spontaneously hypertensive rats.
    BioMed research international, 2013, Volume: 2013

    Topics: Acetylcysteine; Amidohydrolases; Animals; Arginine; Blood Pressure; Glutathione; Humans; Hypertension; Metabolic Networks and Pathways; Nitric Oxide; Oxidative Stress; Rats; Superoxides

2013
The asymmetric dimethylarginine level is associated with the predicted stroke risk in Japanese women.
    Journal of atherosclerosis and thrombosis, 2014, Volume: 21, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Japan; Middle Aged; Odds Ratio; Prognosis; Risk Factors; Stroke

2014
Asymmetric dimethyl L-arginine, nitric oxide and cardiovascular disease in adolescent type 1 diabetics.
    Journal of pediatric endocrinology & metabolism : JPEM, 2014, Volume: 27, Issue:5-6

    Topics: Adolescent; Arginine; Brachial Artery; Cardiovascular Diseases; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Egypt; Electrocardiography; Female; Humans; Lipids; Male; Nitric Oxide; Ultrasonography

2014
Increased levels of asymmetric dimethylarginine are associated with pulmonary arterial hypertension in HIV infection.
    AIDS (London, England), 2014, Feb-20, Volume: 28, Issue:4

    Topics: Adult; Arginine; Biomarkers; Blood Pressure; Catheterization, Swan-Ganz; Cohort Studies; Echocardiography; Familial Primary Pulmonary Hypertension; Female; HIV Infections; Humans; Hypertension, Pulmonary; Male; Middle Aged; Prospective Studies

2014
Ligand-dependent dynamics of the active-site lid in bacterial dimethylarginine dimethylaminohydrolase.
    Biochemistry, 2014, Feb-18, Volume: 53, Issue:6

    Topics: Amidohydrolases; Arginine; Catalytic Domain; Citrulline; Kinetics; Ligands; Molecular Dynamics Simulation; Nuclear Magnetic Resonance, Biomolecular; Pseudomonas aeruginosa

2014
Other factors ought to be kept in mind when analyzing plasma asymmetric dimethylarginine levels.
    American journal of hypertension, 2014, Volume: 27, Issue:3

    Topics: Arginine; Carotid Arteries; Exercise; Female; Humans; Postmenopause; Vascular Stiffness

2014
Response to "Other factors ought to be kept in mind when analyzing plasma asymmetric dimethylarginine levels".
    American journal of hypertension, 2014, Volume: 27, Issue:3

    Topics: Arginine; Carotid Arteries; Exercise; Female; Humans; Postmenopause; Vascular Stiffness

2014
Advanced intrauterine growth restriction is associated with reduced excretion of asymmetric dimethylarginine.
    Early human development, 2014, Volume: 90, Issue:4

    Topics: Adolescent; Adult; Arginine; Case-Control Studies; Female; Fetal Growth Retardation; Humans; Infant, Extremely Low Birth Weight; Infant, Newborn; Male

2014
Asymmetric dimethylarginine and oxidative stress following coronary artery bypass grafting: associations with postoperative outcome.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2014, Volume: 45, Issue:5

    Topics: Aged; Arginine; Coronary Artery Bypass; Dinoprost; Female; Hospital Mortality; Humans; Male; Middle Aged; Myocardial Infarction; Oxidative Stress; Postoperative Complications

2014
Association of asymmetric dimethylarginine levels with treadmill-stress-test-derived prognosticators.
    Clinical biochemistry, 2014, Volume: 47, Issue:7-8

    Topics: Aged; Arginine; Biomarkers; Coronary Artery Disease; Exercise Test; Female; Humans; Male; Middle Aged; Prognosis; Risk Factors

2014
Assessment of inflammatory biomarkers and oxidative stress in pulmonary thromboembolism: follow-up results.
    Inflammation, 2014, Volume: 37, Issue:4

    Topics: Adult; Aged; Antioxidants; Arginine; Case-Control Studies; Female; Follow-Up Studies; Humans; Hypoxia; Inflammation; Interleukin-6; Male; Middle Aged; Oxidative Stress; Prospective Studies; Pulmonary Embolism; Risk Factors; Tumor Necrosis Factor-alpha

2014
Determination of asymmetric Nα-acetyldimethylarginine in humans: a phase II metabolite of asymmetric dimethylarginine.
    Analytical biochemistry, 2014, May-01, Volume: 452

    Topics: Acetylation; Adult; Arginine; Blood Chemical Analysis; Calibration; Female; Humans; Male; Middle Aged; Reference Standards; Reproducibility of Results; Urinalysis; Young Adult

2014
Elevated asymmetric dimethylarginine is associated with oxidant stress aggravation in patients with early stage autosomal dominant polycystic kidney disease.
    Kidney & blood pressure research, 2013, Volume: 38, Issue:1

    Topics: Adolescent; Adult; Aged; Arginine; Dinoprost; Disease Progression; Female; Glomerular Filtration Rate; Humans; Isoprostanes; Kidney Function Tests; Lipoproteins, LDL; Male; Middle Aged; Oxidative Stress; Polycystic Kidney, Autosomal Dominant; Young Adult

2013
Determination of oxidative stress and cellular inflammation in patients with diabetic nephropathy and non-diabetic nephropathy being administered hemodialysis treatment due to chronic renal failure.
    Renal failure, 2014, Volume: 36, Issue:5

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Arginine; Biomarkers; C-Reactive Protein; Case-Control Studies; Deoxyguanosine; Diabetic Nephropathies; Female; Humans; Inflammation; Interleukin-6; Kidney Failure, Chronic; Male; Malondialdehyde; Middle Aged; Neopterin; Oxidative Stress; Tumor Necrosis Factor-alpha

2014
An assessment of correlation between serum asymmetric dimethylarginine and glycated haemoglobin in patients with type 2 diabetes mellitus.
    Bosnian journal of basic medical sciences, 2014, Volume: 14, Issue:1

    Topics: Arginine; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Female; Glycated Hemoglobin; Humans; Hyperglycemia; Male; Middle Aged; Nephelometry and Turbidimetry; Oxidative Stress

2014
The relation of maternal serum eNOS, NOSTRIN and ADMA levels with aetiopathogenesis of preeclampsia and/or intrauterine fetal growth restriction.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2015, Volume: 28, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Adult; Arginine; Case-Control Studies; DNA-Binding Proteins; Female; Fetal Growth Retardation; Humans; Intracellular Signaling Peptides and Proteins; Nitric Oxide Synthase Type III; Pre-Eclampsia; Pregnancy; Young Adult

2015
Reduced sTWEAK and increased sCD163 levels in HIV-infected patients: modulation by antiretroviral treatment, HIV replication and HCV co-infection.
    PloS one, 2014, Volume: 9, Issue:3

    Topics: Adult; Anti-Retroviral Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Arginine; C-Reactive Protein; Case-Control Studies; Coinfection; Cytokine TWEAK; Female; Hepacivirus; Hepatitis C; HIV; HIV Infections; Humans; Interleukin-6; Male; Middle Aged; Receptors, Cell Surface; Tumor Necrosis Factors; Vascular Cell Adhesion Molecule-1; Young Adult

2014
Asymmetric dimethylarginine responses during interferon-α-induced depression in patients with chronic hepatitis C infection.
    Psychosomatic medicine, 2014, Volume: 76, Issue:3

    Topics: Adult; Analysis of Variance; Antiviral Agents; Arginine; Cardiovascular Diseases; Chromatography, Liquid; Depression; Depressive Disorder; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Nitric Oxide Synthase; Prospective Studies; Psychiatric Status Rating Scales; Regression Analysis; Ribavirin; Risk Factors; Time Factors

2014
Pharmacological inhibition of DDAH1 improves survival, haemodynamics and organ function in experimental septic shock.
    The Biochemical journal, 2014, Jun-01, Volume: 460, Issue:2

    Topics: Amidohydrolases; Animals; Arginine; Endotoxemia; Enzyme Inhibitors; Fluid Therapy; Hemodynamics; Macrophages, Peritoneal; Male; Norepinephrine; Peritonitis; Rats; Rats, Wistar; Shock, Septic

2014
Evaluation of asymmetric dimethylarginine (ADMA) levels in children with growth hormone deficiency.
    Journal of clinical research in pediatric endocrinology, 2014, Volume: 6, Issue:1

    Topics: Adolescent; Arginine; Biomarkers; Blood Glucose; Case-Control Studies; Child; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Growth Disorders; Human Growth Hormone; Humans; Insulin; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Male; Prognosis

2014
Exogenous asymmetric dimethylarginine (ADMA) in pathogenesis of ischemia-reperfusion-induced gastric lesions: interaction with protective nitric oxide (NO) and calcitonin gene-related peptide (CGRP).
    International journal of molecular sciences, 2014, Mar-20, Volume: 15, Issue:3

    Topics: Animals; Arginine; Blood Flow Velocity; Calcitonin Gene-Related Peptide; Capsaicin; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Gastric Mucosa; Interleukin-10; Isoxazoles; Male; Malondialdehyde; Nitric Oxide; Rats, Wistar; Reperfusion Injury; Stomach Diseases; Tumor Necrosis Factor-alpha

2014
Endogenous nitric-oxide synthase inhibitor ADMA after acute brain injury.
    International journal of molecular sciences, 2014, Mar-06, Volume: 15, Issue:3

    Topics: Amidohydrolases; Animals; Arginine; Brain Injuries; Immunohistochemistry; Male; Motor Activity; Nitric Oxide; Nitric Oxide Synthase; Protein-Arginine N-Methyltransferases; Rats, Sprague-Dawley; Time Factors

2014
Widespread endotheliopathy in adults with cyanotic congenital heart disease.
    Cardiology in the young, 2015, Volume: 25, Issue:3

    Topics: Adult; Arginine; Brachial Artery; Case-Control Studies; Cell Count; Cyanosis; Endothelial Cells; Endothelial Progenitor Cells; Endothelin-1; Female; Flow Cytometry; Heart Defects, Congenital; Humans; Male; Middle Aged; Nitric Oxide; Retinal Artery; Retinal Vein; Risk Factors

2015
Asymmetric dimethylarginine levels in patients with cutaneous anthrax: a laboratory analysis.
    Annals of clinical microbiology and antimicrobials, 2014, Mar-26, Volume: 13

    Topics: Adolescent; Adult; Aged; Anthrax; Arginine; Biomarkers; Female; Germany; Humans; Male; Middle Aged; Skin Diseases, Bacterial; Young Adult

2014
Effects of eicosapentaenoic acid on the levels of inflammatory markers, cardiac function and long-term prognosis in chronic heart failure patients with dyslipidemia.
    Journal of atherosclerosis and thrombosis, 2014, Volume: 21, Issue:7

    Topics: Aged; Arginine; Biomarkers; Chemokine CCL2; Chromatography, High Pressure Liquid; Chronic Disease; Dyslipidemias; Eicosapentaenoic Acid; Female; Follow-Up Studies; Heart Failure; Humans; Inflammation Mediators; Male; Prognosis; Survival Rate; Ventricular Function, Left

2014
Effect of lowering asymmetric dimethylarginine (ADMA) on vascular pathology in atherosclerotic ApoE-deficient mice with reduced renal mass.
    International journal of molecular sciences, 2014, Mar-31, Volume: 15, Issue:4

    Topics: Amidohydrolases; Animals; Aorta; Apolipoproteins E; Arginine; Atherosclerosis; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nephrectomy; Nitric Oxide Synthase; Plaque, Atherosclerotic; Renal Insufficiency, Chronic; Transaminases

2014
Relationship between c-reactive protein and the asymmetric dimethylarginine-induced endothelial dysfunction pathway in vasospastic angina.
    Die Pharmazie, 2014, Volume: 69, Issue:3

    Topics: Aged; Angina, Unstable; Arginine; Biomarkers; Brachial Artery; C-Reactive Protein; Coronary Angiography; Coronary Vasospasm; Endothelium, Vascular; Female; Humans; Hyperventilation; Lipoproteins, LDL; Logistic Models; Male; Middle Aged; Risk Factors; Smoking; Tomography, X-Ray Computed; Vasodilation

2014
Structural determinants for the strict monomethylation activity by trypanosoma brucei protein arginine methyltransferase 7.
    Structure (London, England : 1993), 2014, May-06, Volume: 22, Issue:5

    Topics: Amino Acid Sequence; Arginine; Catalytic Domain; Crystallography, X-Ray; Guanidine; Histones; Methylation; Models, Molecular; Molecular Sequence Data; Protein Multimerization; Protein-Arginine N-Methyltransferases; Protozoan Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Trypanosoma brucei brucei

2014
Asymmetric dimethylarginine in chronic obstructive pulmonary disease (ADMA in COPD).
    International journal of molecular sciences, 2014, Apr-10, Volume: 15, Issue:4

    Topics: Aged; Arginase; Arginine; Chromatography, High Pressure Liquid; Female; Forced Expiratory Volume; Humans; Lung; Male; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Pulmonary Disease, Chronic Obstructive; Sputum; Tandem Mass Spectrometry

2014
ADMA/SDMA in elderly subjects with asymptomatic carotid atherosclerosis: values and site-specific association.
    International journal of molecular sciences, 2014, Apr-15, Volume: 15, Issue:4

    Topics: Aged; Aged, 80 and over; Arginine; C-Reactive Protein; Carotid Arteries; Carotid Artery Diseases; Carotid Intima-Media Thickness; Cholesterol; Cholesterol, LDL; Female; Humans; Male; Middle Aged; Triglycerides

2014
Interactions between inflammatory activation and endothelial dysfunction selectively modulate valve disease progression in patients with bicuspid aortic valve.
    Heart (British Cardiac Society), 2014, Volume: 100, Issue:10

    Topics: Aorta; Aortic Valve; Arginine; Bicuspid Aortic Valve Disease; Biomarkers; Disease Progression; Echocardiography; Endothelium, Vascular; Female; Follow-Up Studies; Heart Valve Diseases; Humans; Inflammation; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Nitric Oxide Synthase; Peroxidase; Prognosis; Retrospective Studies; Severity of Illness Index; Vasodilation

2014
Asymmetric dimethylarginine levels in children with β-thalassemia and their correlations to tricuspid regurgitant jet velocity.
    Pediatric blood & cancer, 2014, Volume: 61, Issue:9

    Topics: Adolescent; Arginine; beta-Thalassemia; Case-Control Studies; Child; Echocardiography, Doppler; Female; Follow-Up Studies; Humans; Hypertension, Pulmonary; Male; Prognosis; Risk Factors; Tricuspid Valve Insufficiency

2014
[Effects of continuous positive airway pressure treatment of inflammatory factors in patients with overlap syndrome].
    Zhonghua yi xue za zhi, 2014, Feb-18, Volume: 94, Issue:6

    Topics: Adult; Aged; Arginine; C-Reactive Protein; Continuous Positive Airway Pressure; Female; Humans; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Sleep Apnea, Obstructive; Tumor Necrosis Factor-alpha

2014
The effects of Ramadan fasting on endothelial function in patients with cardiovascular diseases.
    European journal of clinical nutrition, 2014, Volume: 68, Issue:7

    Topics: Adult; Arginine; Cardiovascular Diseases; Cerebrovascular Disorders; Coronary Artery Disease; Endothelium, Vascular; Fasting; Humans; Islam; Male; Malondialdehyde; Middle Aged; Nitric Oxide; Peripheral Arterial Disease; Vascular Endothelial Growth Factor A

2014
L-arginine/NO pathway is altered in children with haemolytic-uraemic syndrome (HUS).
    Oxidative medicine and cellular longevity, 2014, Volume: 2014

    Topics: Arginine; Case-Control Studies; Child; Child, Preschool; Female; Hemoglobins; Hemolytic-Uremic Syndrome; Hospitalization; Humans; Male; Nitrates; Nitric Oxide; Nitrites; Peritoneal Dialysis; Signal Transduction

2014
Regulation of endothelial progenitor cell differentiation and function by dimethylarginine dimethylaminohydrolase 2 in an asymmetric dimethylarginine-independent manner.
    Cell biology international, 2014, Volume: 38, Issue:9

    Topics: Amidohydrolases; Arginine; Cell Differentiation; Cells, Cultured; Cellular Senescence; Endothelial Progenitor Cells; Humans; RNA Interference; RNA, Messenger; RNA, Small Interfering; Sirtuin 1; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2014
Asymmetric dimethylarginine does not inhibit arginase activity and is pro-proliferative in pulmonary endothelial cells.
    Clinical and experimental pharmacology & physiology, 2014, Volume: 41, Issue:7

    Topics: Animals; Arginase; Arginine; Cattle; Cell Proliferation; Endothelial Cells; Lung; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Substrate Specificity; Urea

2014
Relation of asymmetric dimethylarginine levels to macrovascular disease and inflammation markers in type 2 diabetic patients.
    Journal of diabetes research, 2014, Volume: 2014

    Topics: Aged; Arginine; Atherosclerosis; Biomarkers; Blood Sedimentation; C-Reactive Protein; Carotid Intima-Media Thickness; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Fibrinogen; Homocysteine; Humans; Inflammation Mediators; Male; Middle Aged; Regression Analysis; Systemic Vasculitis; Up-Regulation

2014
Increased cerebrospinal fluid concentrations of asymmetric dimethylarginine correlate with adverse clinical outcome in subarachnoid hemorrhage patients.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2014, Volume: 21, Issue:8

    Topics: Adult; Aged; Arginine; Chromatography, High Pressure Liquid; Disease Progression; Female; Follow-Up Studies; Humans; Logistic Models; Male; Middle Aged; Prognosis; Severity of Illness Index; Spinal Puncture; Subarachnoid Hemorrhage; Time Factors; Ultrasonography, Doppler, Transcranial; Vasospasm, Intracranial

2014
Incidence of all-cause and cardiovascular mortality predicted by symmetric dimethylarginine in the population-based study of health in pomerania.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Cardiovascular Diseases; Female; Humans; Incidence; Male; Middle Aged; Young Adult

2014
Plasma ADMA concentrations associate with aerobic fitness in postmenopausal women.
    Life sciences, 2014, Jul-11, Volume: 108, Issue:1

    Topics: Aged; Arginine; Exercise; Female; Humans; Middle Aged; Oxygen Consumption; Physical Fitness; Postmenopause

2014
Aliskiren in early postnatal life prevents hypertension and reduces asymmetric dimethylarginine in offspring exposed to maternal caloric restriction.
    Journal of the renin-angiotensin-aldosterone system : JRAAS, 2015, Volume: 16, Issue:3

    Topics: Amides; Angiotensin-Converting Enzyme 2; Animals; Animals, Newborn; Arginine; Blood Pressure; Blotting, Western; Body Weight; Caloric Restriction; Female; Fumarates; Gene Expression Regulation; Histone Deacetylases; Hypertension; Losartan; Male; Peptidyl-Dipeptidase A; Rats, Sprague-Dawley

2015
Does asymmetric dimethylarginine (ADMA) plasma concentration predict esophageal varices in patients with cirrhosis?
    Clinical laboratory, 2014, Volume: 60, Issue:5

    Topics: Aged; Arginine; Biomarkers; Esophageal and Gastric Varices; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Predictive Value of Tests

2014
Asymmetric dimethylarginine and whole blood viscosity in renal failure.
    Clinical hemorheology and microcirculation, 2015, Volume: 59, Issue:3

    Topics: Adult; Arginine; Blood Viscosity; Female; Humans; Kidney Failure, Chronic; Male; Risk Factors; Young Adult

2015
Resting brain perfusion and selected vascular risk factors in healthy elderly subjects.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Aged; Arginine; Brain; Caffeine; Cerebrovascular Circulation; Female; Hematocrit; Homocysteine; Humans; Male; Middle Aged; Risk Factors

2014
Differential associations of inflammatory and endothelial biomarkers with disease activity in rheumatoid arthritis of short duration.
    Mediators of inflammation, 2014, Volume: 2014

    Topics: Adult; Arginine; Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; E-Selectin; Female; Humans; Interleukin-6; Male; Middle Aged; Osteoprotegerin; Risk Factors; Serum Amyloid P-Component; Vascular Cell Adhesion Molecule-1; von Willebrand Factor

2014
Melatonin therapy prevents programmed hypertension and nitric oxide deficiency in offspring exposed to maternal caloric restriction.
    Oxidative medicine and cellular longevity, 2014, Volume: 2014

    Topics: Animals; Arginine; Caloric Restriction; Female; Hypertension; In Vitro Techniques; Kidney; Male; Melatonin; Nitric Oxide; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley

2014
Asymmetric and symmetric dimethylarginine are associated with coronary artery lesions in Kawasaki disease.
    The Journal of pediatrics, 2014, Volume: 165, Issue:2

    Topics: Arginine; Biomarkers; Child, Preschool; Coronary Artery Disease; Coronary Vessels; Female; Humans; Immunoglobulins, Intravenous; Infant; Male; Mucocutaneous Lymph Node Syndrome

2014
Simultaneous determination of N(G)-monomethyl-L-arginine, N(G),N(G)-dimethyl-L-arginine, N(G),N(G')-dimethyl-L-arginine, and L-arginine using monolithic silica disk-packed spin columns and a monolithic silica column.
    Journal of separation science, 2014, Volume: 37, Issue:16

    Topics: Arginine; Calibration; Chromatography, High Pressure Liquid; Fluorescent Dyes; Healthy Volunteers; Humans; Linear Models; omega-N-Methylarginine; Reproducibility of Results; Silicon Dioxide; Solid Phase Extraction

2014
miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia.
    The Biochemical journal, 2014, Aug-15, Volume: 462, Issue:1

    Topics: Amidohydrolases; Animals; Arginine; Cells, Cultured; Cyclic GMP; Endothelial Cells; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Hypoxia; Lung; Male; Mice; Mice, Transgenic; MicroRNAs; Myocytes, Smooth Muscle

2014
Involvement of increased endogenous asymmetric dimethylarginine in the hepatic endoplasmic reticulum stress of type 2 diabetic rats.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: Animals; Arginine; Cell Line, Tumor; Diabetes Mellitus, Type 2; Endoplasmic Reticulum Stress; Liver; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Signal Transduction

2014
GC-MS and GC-MS/MS measurement of the cardiovascular risk factor homoarginine in biological samples.
    Amino acids, 2014, Volume: 46, Issue:9

    Topics: Arginine; Cardiovascular Diseases; Female; Gas Chromatography-Mass Spectrometry; Homoarginine; Humans; Male; Risk Factors; Sputum

2014
Asymmetric dimethylarginine and progression of chronic kidney disease: a one-year follow-up study.
    Kidney & blood pressure research, 2014, Volume: 39, Issue:1

    Topics: Advanced Oxidation Protein Products; Aged; Arginine; Biomarkers; Case-Control Studies; Disease Progression; Female; Follow-Up Studies; Glomerular Filtration Rate; Glycation End Products, Advanced; Humans; Longitudinal Studies; Male; Middle Aged; Oxidative Stress; Prognosis; Prospective Studies; Renal Insufficiency, Chronic

2014
Serum reference intervals of homoarginine, ADMA, and SDMA in the study of health in Pomerania.
    Clinical chemistry and laboratory medicine, 2014, Volume: 52, Issue:12

    Topics: Adult; Aged; Arginine; Biomarkers; Body Mass Index; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Female; Homoarginine; Humans; Male; Middle Aged; Reference Values; Renal Insufficiency, Chronic; Risk Factors; Tandem Mass Spectrometry

2014
Time course of asymmetric dimethylarginine and symmetric dimethylarginine levels after successful renal transplantation.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2014, Volume: 29, Issue:10

    Topics: Adult; Aged; Arginine; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Glomerular Filtration Rate; Humans; Kidney Transplantation; Male; Middle Aged; Postoperative Complications; Prospective Studies; Renal Insufficiency, Chronic; Risk Factors; Young Adult

2014
Asymmetric dimethylarginine is associated with high-sensitivity C-reactive protein and early carotid atherosclerosis in women with previous gestational diabetes mellitus.
    Endocrine, 2015, Volume: 48, Issue:2

    Topics: Adult; Arginine; C-Reactive Protein; Carotid Artery Diseases; Carotid Intima-Media Thickness; Diabetes, Gestational; Female; Humans; Inflammation; Pregnancy

2015
Asymmetric dimethylarginine, race, and mortality in hemodialysis patients.
    Clinical journal of the American Society of Nephrology : CJASN, 2014, Aug-07, Volume: 9, Issue:8

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Black or African American; Boston; Cause of Death; Female; Humans; Kidney Failure, Chronic; Linear Models; Male; Middle Aged; Multivariate Analysis; Prognosis; Proportional Hazards Models; Renal Dialysis; Risk Factors; Time Factors

2014
Role of alanine:glyoxylate aminotransferase 2 in metabolism of asymmetric dimethylarginine in the settings of asymmetric dimethylarginine overload and bilateral nephrectomy.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2014, Volume: 29, Issue:11

    Topics: Acute Kidney Injury; Alanine; Animals; Arginine; Biomarkers; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Infusions, Intravenous; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Nephrectomy; Real-Time Polymerase Chain Reaction; RNA; Transaminases

2014
Circulating dickkopf-1 in diabetes mellitus: association with platelet activation and effects of improved metabolic control and low-dose aspirin.
    Journal of the American Heart Association, 2014, Jul-18, Volume: 3, Issue:4

    Topics: Aged; Arginine; Aspirin; Biomarkers; Cardiovascular Diseases; Case-Control Studies; CD40 Ligand; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Intercellular Signaling Peptides and Proteins; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Thromboxane B2; Wnt Signaling Pathway

2014
Association between brachial-ankle pulse wave velocity and the ratio of l-arginine to asymmetric dimethylarginine in patients undergoing coronary angiography.
    Journal of cardiology, 2015, Volume: 65, Issue:4

    Topics: Aged; Ankle Brachial Index; Arginine; Blood Pressure; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studies; Female; Heart Rate; Hematocrit; Hemoglobins; Humans; Kidney; Male; Middle Aged; Natriuretic Peptide, Brain; Pulse Wave Analysis; Vascular Stiffness

2015
Relationship between asymmetric dimethylarginine and nocturia in the general elderly population: The HEIJO-KYO cohort.
    Neurourology and urodynamics, 2015, Volume: 34, Issue:8

    Topics: Aged; Aged, 80 and over; Arginine; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Nocturia; Prevalence

2015
Successful catheter ablation decreases platelet activation and improves endothelial function in patients with atrial fibrillation.
    Heart rhythm, 2014, Volume: 11, Issue:11

    Topics: Aged; Arginine; Atrial Fibrillation; Biomarkers; Catheter Ablation; Electrocardiography; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Integrin beta3; Male; Middle Aged; P-Selectin; Platelet Activation; Prospective Studies; Recurrence; Stroke

2014
Asymmetric dimethylarginine (ADMA) and treatment response relationship in male patients with first-episode schizophrenia: a controlled study.
    Psychiatry research, 2014, Dec-15, Volume: 220, Issue:1-2

    Topics: Adult; Antipsychotic Agents; Arginine; Humans; Male; Middle Aged; Nitric Oxide; Schizophrenia; Treatment Outcome; Young Adult

2014
Changes in serum asymmetric dimethylarginine and endothelial markers levels with varying periods of hemodialysis.
    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2014, Volume: 18, Issue:4

    Topics: Adult; Aged; Arginine; Case-Control Studies; Female; Humans; Intercellular Adhesion Molecule-1; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Renal Dialysis; Time Factors; Vascular Cell Adhesion Molecule-1

2014
Rho/ROCK signal cascade mediates asymmetric dimethylarginine-induced vascular smooth muscle cells migration and phenotype change.
    BioMed research international, 2014, Volume: 2014

    Topics: Animals; Arginine; Biomarkers; Cell Differentiation; Cell Movement; Cell Proliferation; Cell Shape; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenotype; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction

2014
Aging of the nitric oxide system: are we as old as our NO?
    Journal of the American Heart Association, 2014, Aug-18, Volume: 3, Issue:4

    Topics: Aged; Aging; Arginine; Blood Platelets; Cardiovascular Diseases; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitric Oxide; Platelet Aggregation; Prospective Studies

2014
The ability of asymmetric dimethylarginine (ADMA) or monomethylarginine (L-NMMA) to block endothelium-dependent, nitric oxide-mediated relaxation in rat aorta is inversely related to the efficacy of the relaxant stimulus.
    European journal of pharmacology, 2014, Oct-15, Volume: 741

    Topics: Animals; Aorta; Arginine; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Wistar; Vasodilation

2014
Propargylglycine aggravates liver damage in LPS-treated rats: Possible relation of nitrosative stress with the inhibition of H2S formation.
    Pharmacological reports : PR, 2014, Volume: 66, Issue:5

    Topics: Alkynes; Amidohydrolases; Animals; Arginine; Aspartate Aminotransferases; Chromatography, High Pressure Liquid; Cystathionine gamma-Lyase; Endotoxemia; Glutathione; Glycine; Hydrogen Sulfide; Lipopolysaccharides; Liver Diseases; Male; Peroxidase; Rats; Rats, Wistar; Stress, Physiological; Tyrosine

2014
Competitive interaction between fibroblast growth factor 23 and asymmetric dimethylarginine in patients with CKD.
    Journal of the American Society of Nephrology : JASN, 2015, Volume: 26, Issue:4

    Topics: Adult; Aged; Arginine; Cohort Studies; Disease Progression; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Humans; Italy; Male; Middle Aged; Renal Insufficiency, Chronic

2015
Irbesartan inhibits advanced glycation end product-induced increase in asymmetric dimethylarginine level in mesangial cells through its anti-oxidative properties.
    International journal of cardiology, 2014, Oct-20, Volume: 176, Issue:3

    Topics: Antioxidants; Arginine; Biphenyl Compounds; Cells, Cultured; Glycation End Products, Advanced; Humans; Irbesartan; Mesangial Cells; Tetrazoles

2014
Metformin reduces asymmetric dimethylarginine and prevents hypertension in spontaneously hypertensive rats.
    Translational research : the journal of laboratory and clinical medicine, 2014, Volume: 164, Issue:6

    Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Body Weight; Hypertension; Kidney; Lung; Male; Metformin; Nitric Oxide; Rats, Inbred SHR; Rats, Inbred WKY

2014
Risk of acute cerebral infarction and plasma asymmetrical dimethylarginine and homocysteine levels: a clinical correlation analysis of Chinese population.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2014, Volume: 23, Issue:9

    Topics: Aged; Arginine; Asian People; Case-Control Studies; Cerebral Infarction; China; Female; Homocysteine; Humans; Male; Middle Aged; Risk; Risk Factors; Socioeconomic Factors

2014
Circulating asymmetric dimethylarginine and lipid profile in pre-pubertal children with growth hormone deficiency: effect of 12-month growth hormone replacement therapy.
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2014, Volume: 24, Issue:5

    Topics: Arginine; Blood Glucose; Case-Control Studies; Child; Female; Follow-Up Studies; Growth Disorders; Hormone Replacement Therapy; Human Growth Hormone; Humans; Insulin Resistance; Lipid Metabolism; Lipids; Male; Puberty; Time Factors

2014
Plasma homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in patients with rheumatoid arthritis: is homoarginine a cardiovascular corrective in rheumatoid arthritis, an anti-ADMA?
    International journal of cardiology, 2014, Oct-20, Volume: 176, Issue:3

    Topics: Arginine; Arthritis, Rheumatoid; Biomarkers; Female; Homoarginine; Humans; Male

2014
Possible role of nitric oxide (NO) in the regulation of gender related differences in stress induced anxiogenesis in rats.
    Nitric oxide : biology and chemistry, 2014, Dec-01, Volume: 43

    Topics: Androstenedione; Animals; Anxiety; Arginine; Behavior, Animal; Brain; Enzyme Inhibitors; Female; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Sex Factors; Stress, Physiological

2014
Omega-3 fatty acids supplementation improves endothelial function and maximal oxygen uptake in endurance-trained athletes.
    European journal of sport science, 2015, Volume: 15, Issue:4

    Topics: Adolescent; Adult; Arginine; Bicycling; Dietary Supplements; Endothelium; Fatty Acids, Omega-3; Humans; Male; Nitric Oxide; Oxygen Consumption; Physical Fitness; Pulse Wave Analysis; Ultrasonography; Vasodilation; Young Adult

2015
Cumulative inflammation associates with asymmetric dimethylarginine in rheumatoid arthritis: a 6 year follow-up study.
    Rheumatology (Oxford, England), 2015, Volume: 54, Issue:7

    Topics: Aged; Arginine; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; C-Reactive Protein; Cardiovascular Diseases; Cohort Studies; Disease Progression; Female; Follow-Up Studies; Humans; Inflammation; Longitudinal Studies; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Regression Analysis; Risk Factors; Severity of Illness Index

2015
Relationship between dimethylarginine dimethylaminohydrolase gene variants and asymmetric dimethylarginine in patients with rheumatoid arthritis.
    Atherosclerosis, 2014, Volume: 237, Issue:1

    Topics: Aged; Amidohydrolases; Analysis of Variance; Arginine; Arthritis, Rheumatoid; Female; Genetic Variation; Humans; Inflammation; Insulin Resistance; Male; Middle Aged; Multivariate Analysis; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Risk Factors; Treatment Outcome

2014
Early exercise training after renal transplantation and asymmetric dimethylarginine: the effect of obesity.
    Kidney & blood pressure research, 2014, Volume: 39, Issue:4

    Topics: Adult; Aged; Anthropometry; Arginine; Blood Pressure; Cohort Studies; Exercise Therapy; Female; Glycated Hemoglobin; Humans; Insulin; Kidney Transplantation; Lipids; Male; Middle Aged; Obesity; Physical Fitness; Prospective Studies

2014
Asymmetric dimethylarginine triggers macrophage apoptosis via the endoplasmic reticulum stress pathway.
    Molecular and cellular biochemistry, 2015, Volume: 398, Issue:1-2

    Topics: Apoptosis; Arginine; Blotting, Western; Caspases, Initiator; Cell Line, Tumor; Dose-Response Relationship, Drug; eIF-2 Kinase; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Endoribonucleases; Heat-Shock Proteins; Humans; JNK Mitogen-Activated Protein Kinases; Macrophages; Models, Biological; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Time Factors; Transcription Factor CHOP

2015
Levels of arginine and its products in dialysis patients.
    European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:16

    Topics: Adult; Aged; Arginine; Coronary Artery Disease; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Renal Dialysis

2014
Cardiovascular-renal changes after kidney donation: one-year follow-up study.
    Transplantation, 2015, Volume: 99, Issue:4

    Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Interleukin-6; Kidney Diseases; Male; Middle Aged; Multivariate Analysis; Nephrectomy; Prospective Studies; Risk Factors; Time Factors; Tissue Donors; Treatment Outcome; Uric Acid; Vascular Cell Adhesion Molecule-1; Vasodilation; Young Adult

2015
Monocyte activation, but not microbial translocation, is independently associated with markers of endovascular dysfunction in HIV-infected patients receiving cART.
    Journal of acquired immune deficiency syndromes (1999), 2014, Dec-01, Volume: 67, Issue:4

    Topics: Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Arginine; Bacterial Translocation; Biomarkers; Cardiovascular Diseases; Female; Fibrin Fibrinogen Degradation Products; HIV Infections; Humans; Lipopolysaccharide Receptors; Lipopolysaccharides; Male; Middle Aged; Monocytes

2014
Could plasma asymmetric dimethylarginine level be a novel predictor beyond the classic predictors of stent restenosis?
    Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2014, Volume: 14, Issue:6

    Topics: Arginine; Biomarkers; C-Reactive Protein; Coronary Angiography; Coronary Restenosis; Cross-Sectional Studies; Female; Humans; Logistic Models; Male; Predictive Value of Tests

2014
Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension.
    Molecular biology reports, 2015, Volume: 42, Issue:1

    Topics: Animals; Antioxidants; Arginine; Biomarkers; Blood Pressure; Blood Vessels; Desoxycorticosterone Acetate; Endothelium, Vascular; Fluorescent Antibody Technique; Histones; Hydrogen Sulfide; Hypertension; Lysine; Male; Methylation; Nitrites; Rats, Wistar; Renal Artery; Resveratrol; Stilbenes; Systole; Vasodilation

2015
Is arginine/asymetric dimethylarginine ratio depletion an indicator of insufficient resuscitation in a porcine model of hemorrhage-reperfusion?
    Surgery, 2014, Volume: 156, Issue:4

    Topics: Animals; Arginine; Biomarkers; Chromatography, Liquid; Citrulline; Female; Fluid Therapy; Interleukin-6; Male; Mass Spectrometry; Resuscitation; Shock, Hemorrhagic; Sus scrofa

2014
Discussion.
    Surgery, 2014, Volume: 156, Issue:4

    Topics: Animals; Arginine; Female; Fluid Therapy; Male; Resuscitation; Shock, Hemorrhagic

2014
Changes in ADMA/DDAH pathway after hepatic ischemia/reperfusion injury in rats: the role of bile.
    BioMed research international, 2014, Volume: 2014

    Topics: Amidohydrolases; Animals; Arginine; Bile; Cationic Amino Acid Transporter 2; Disease Models, Animal; Liver; Male; Organ Specificity; Oxidative Stress; Protein-Arginine N-Methyltransferases; Rats; Rats, Wistar; Reperfusion Injury

2014
[Effect of matrine on NO and ADMA metabolism pathways in serum and tissues of mice with lipopolysaccharide-induced intestine tissue inflammation].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2014, Volume: 39, Issue:12

    Topics: Alkaloids; Animals; Arginine; Humans; Inflammation; Intestinal Diseases; Intestinal Mucosa; Intestines; Lipopolysaccharides; Male; Matrines; Mice; Nitric Oxide; Protein-Arginine N-Methyltransferases; Quinolizines

2014
Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine.
    Circulation. Cardiovascular genetics, 2014, Volume: 7, Issue:6

    Topics: Adult; Aged; Amidohydrolases; Arginine; Binding Sites; Cohort Studies; Female; Genetic Loci; Genome-Wide Association Study; Genotype; HEK293 Cells; Humans; Male; Mediator Complex; Middle Aged; Polymorphism, Single Nucleotide; Protein Structure, Tertiary; Risk Factors; Stroke; Substrate Specificity; Transaminases

2014
High-tone external muscle stimulation in patients with acute kidney injury (AKI): beneficial effects on NO metabolism, asymmetric dimethylarginine, and endothelin-1.
    Clinical nephrology, 2014, Volume: 82, Issue:5

    Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Arginine; Cohort Studies; Electric Stimulation Therapy; Endothelin-1; Female; Humans; Leg; Male; Middle Aged; Muscle, Skeletal; Nitric Oxide; Renal Dialysis

2014
Antidiabetic drug metformin is effective on the metabolism of asymmetric dimethylarginine in experimental liver injury.
    Diabetes research and clinical practice, 2014, Volume: 106, Issue:2

    Topics: Alanine Transaminase; Amidohydrolases; Animals; Arginine; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione; Hypoglycemic Agents; Lipopolysaccharides; Male; Metformin; Peroxidase; Protective Agents; Rats; Rats, Sprague-Dawley

2014
IGF-1 and ADMA levels are inversely correlated in nondiabetic ankylosing spondylitis patients undergoing anti-TNF-alpha therapy.
    BioMed research international, 2014, Volume: 2014

    Topics: Adipokines; Antibodies, Monoclonal; Arginine; Female; Humans; Inflammation; Infliximab; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Male; Metabolic Syndrome; Nitric Oxide; Nitric Oxide Synthase; Osteopontin; Osteoporosis; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha

2014
Serelaxin reduces oxidative stress and asymmetric dimethylarginine in angiotensin II-induced hypertension.
    American journal of physiology. Renal physiology, 2014, Dec-15, Volume: 307, Issue:12

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Arginine; Arterial Pressure; Dinoprost; Disease Models, Animal; Down-Regulation; Humans; Hypertension; Injections, Subcutaneous; Kidney; Liver; Male; NADPH Oxidases; Nitric Oxide; Oxidative Stress; Proteinuria; Rats, Sprague-Dawley; Recombinant Proteins; Relaxin; Thiobarbituric Acid Reactive Substances

2014
Cardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regulation of DDAH/ADMA metabolism pathway in rats.
    European journal of pharmacology, 2014, Dec-15, Volume: 745

    Topics: Alkaloids; Amidohydrolases; Animals; Arginine; Cardiotonic Agents; Disease Models, Animal; Female; Heart Failure; Hemodynamics; Isoproterenol; Male; Metabolic Networks and Pathways; Myocardium; Natriuretic Peptide, Brain; Organ Size; Protein-Arginine N-Methyltransferases; Quinolizines; Rats; Rats, Sprague-Dawley; Troponin I

2014
Plasma asymmetric dimethylarginine levels are increased in neonates with bronchopulmonary dysplasia-associated pulmonary hypertension.
    The Journal of pediatrics, 2015, Volume: 166, Issue:2

    Topics: Arginine; Bronchopulmonary Dysplasia; Case-Control Studies; Humans; Hypertension, Pulmonary; Infant, Newborn

2015
Asymmetric dimethylarginine attenuates the association of melatonin secretion with night-time blood pressure and dipping in elderly individuals.
    Circulation journal : official journal of the Japanese Circulation Society, 2014, Volume: 78, Issue:12

    Topics: Aged; Aged, 80 and over; Aging; Arginine; Blood Pressure; Body Mass Index; Circadian Rhythm; Cross-Sectional Studies; Diabetes Mellitus; Endothelium, Vascular; Female; Humans; Hypertension; Male; Melatonin; Nitric Oxide; Nitric Oxide Synthase Type III; Secretory Rate; Smoking

2014
Circulating levels of apelin, glucagon-like peptide and visfatin in hypercholesterolemic-hyperhomocysteinemic guinea-pigs: their relation with NO metabolism.
    Molecular and cellular biochemistry, 2015, Volume: 400, Issue:1-2

    Topics: Animals; Arginine; Cholesterol; Glucagon-Like Peptides; Guinea Pigs; Humans; Hyperhomocysteinemia; Intercellular Signaling Peptides and Proteins; Male; Nicotinamide Phosphoribosyltransferase; Nitric Oxide; Tyrosine

2015
Effects of apocynin, an NADPH oxidase inhibitor, on levels of ADMA, MPO, iNOS and TLR4 induced by myocardial ischemia reperfusion.
    Perfusion, 2015, Volume: 30, Issue:6

    Topics: Acetophenones; Animals; Arginine; Male; Myocardial Reperfusion Injury; Myocardium; NADPH Oxidases; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Sprague-Dawley; Toll-Like Receptor 4

2015
Synergism between asymmetric dimethylarginine (ADMA) and a genetic marker of uric acid in CKD progression.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2015, Volume: 25, Issue:2

    Topics: Aged; Alleles; Arginine; C-Reactive Protein; Calcium; Case-Control Studies; Cohort Studies; Creatinine; Disease Progression; Endpoint Determination; Female; Follow-Up Studies; Genetic Markers; Glucose Transport Proteins, Facilitative; Hemoglobins; Humans; Hyperuricemia; Male; Middle Aged; Nitric Oxide Synthase; Polymorphism, Single Nucleotide; Proportional Hazards Models; Renal Insufficiency, Chronic; Serum Albumin; Uric Acid

2015
Immunomodulatory and antioxidant function of albumin stabilises the endothelium and improves survival in a rodent model of chronic liver failure.
    Journal of hepatology, 2015, Volume: 62, Issue:4

    Topics: Albumins; Animals; Arginine; Disease Models, Animal; End Stage Liver Disease; Endothelium, Vascular; Hemodynamics; Humans; Inflammation; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; von Willebrand Factor

2015
Plasma asymmetric dimethylarginine in infants with bronchopulmonary dysplasia: a promising biomarker despite uncertain pathogenic significance.
    The Journal of pediatrics, 2015, Volume: 166, Issue:2

    Topics: Arginine; Bronchopulmonary Dysplasia; Humans; Hypertension, Pulmonary

2015
Renal transplantation promptly restores excretory function but disturbed L-arginine metabolism persists in patients during the early period after surgery.
    Nitric oxide : biology and chemistry, 2015, Jan-30, Volume: 44

    Topics: Adult; Arginine; Citrulline; Creatinine; Female; Humans; Kidney Transplantation; Male; Middle Aged; Nitric Oxide; Postoperative Complications; Young Adult

2015
Effect of 18β-glycyrrhetinic acid on cerebral vasospasm caused by asymmetric dimethylarginine after experimental subarachnoid hemorrhage in rats.
    Neurological research, 2015, Volume: 37, Issue:6

    Topics: Animals; Arginine; Basilar Artery; Blotting, Western; Connexin 43; Connexins; Disease Models, Animal; Glycyrrhetinic Acid; Neuroprotective Agents; Random Allocation; Rats, Sprague-Dawley; Severity of Illness Index; Subarachnoid Hemorrhage; Time Factors; Vasospasm, Intracranial

2015
Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs.
    Circulation, 2015, Feb-17, Volume: 131, Issue:7

    Topics: Adult; Animals; Anti-Inflammatory Agents; Arginine; Biomarkers; Cardiovascular Diseases; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Culture Techniques; Young Adult

2015
Asymmetric dimethylarginine is associated with carotid atherosclerosis in patients with essential hypertension.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2015, Volume: 37, Issue:5

    Topics: Arginine; Atherosclerosis; Biomarkers; Blood Pressure; Carotid Artery Diseases; Carotid Artery, Common; Carotid Artery, Internal; Carotid Intima-Media Thickness; Essential Hypertension; Female; Humans; Hypertension; Male; Middle Aged; Retrospective Studies; Ultrasonography, Doppler

2015
Asymmetric dimethylarginine exacerbates Aβ-induced toxicity and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease.
    Free radical biology & medicine, 2015, Volume: 79

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Arginine; Caenorhabditis elegans; Disease Models, Animal; Gene Knockdown Techniques; Humans; MAP Kinase Signaling System; Oxidative Stress; Protein-Arginine N-Methyltransferases; Repressor Proteins

2015
Glycated peptides are associated with the variability of endothelial dysfunction in the cerebral vessels and the kidney in type 2 diabetes mellitus patients: a cross-sectional study.
    Journal of diabetes and its complications, 2015, Volume: 29, Issue:2

    Topics: Aged; Albuminuria; Arginine; Biomarkers; Breath Holding; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Endothelium, Vascular; Female; Glomerular Filtration Rate; Glycation End Products, Advanced; Humans; Kidney; Male; Middle Aged; Outpatient Clinics, Hospital; Romania; Severity of Illness Index; Vasculitis, Central Nervous System

2015
Endothelial dysfunction and insulin resistance in young women with polycystic ovarian syndrome.
    Turkish journal of medical sciences, 2014, Volume: 44, Issue:5

    Topics: Adult; Arginine; Body Mass Index; Endothelium, Vascular; Female; Humans; Insulin Resistance; Nitric Oxide; Polycystic Ovary Syndrome; Young Adult

2014
Asymmetric dimethyl arginine levels in chronic hemodialysis patients.
    Turkish journal of medical sciences, 2014, Volume: 44, Issue:4

    Topics: Adult; Aged; Arginine; Biomarkers; C-Reactive Protein; Case-Control Studies; Cholesterol; Cross-Sectional Studies; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Serum Albumin

2014
Soluble CD14 is associated with markers of vascular dysfunction in bariatric surgery patients.
    Metabolic syndrome and related disorders, 2015, Volume: 13, Issue:3

    Topics: Adipose Tissue; Adult; Age Factors; Arginine; Bariatric Surgery; Biomarkers; Female; Humans; Lipopolysaccharide Receptors; Lipopolysaccharides; Male; Middle Aged; Monocytes; Obesity; Prospective Studies; Risk Factors; Sex Factors; Vascular Diseases

2015
Plasma arginine/ADMA ratio as a sensitive risk marker for atherosclerosis: Shimane CoHRE study.
    Atherosclerosis, 2015, Volume: 239, Issue:1

    Topics: Aged; Arginine; Atherosclerosis; Biomarkers; Blood Pressure; Body Mass Index; Carotid Arteries; Carotid Artery, Common; Carotid Intima-Media Thickness; Cohort Studies; Cross-Sectional Studies; Female; Humans; Hypertension; Japan; Male; Middle Aged; Risk Factors

2015
Relationship between asymmetric dimethylarginine plasma level and left ventricular mass in hemodialysis patients.
    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2015, Volume: 26, Issue:1

    Topics: Adult; Arginine; Female; Glomerular Filtration Rate; Humans; Hypertension; Hypertrophy, Left Ventricular; Kidney Failure, Chronic; Male; Middle Aged; Organ Size; Renal Dialysis; Ultrasonography; Ventricular Dysfunction, Left

2015
[The relationship between serum asymmetric dimethylarginine and ABCD2 score in transient ischemic attack patients].
    Zhonghua nei ke za zhi, 2014, Volume: 53, Issue:11

    Topics: Arginine; Case-Control Studies; Cerebral Infarction; Humans; Ischemic Attack, Transient; Risk Factors; Stroke

2014
Plasma Homocysteine and Asymmetrical Dimethyl-l-Arginine (ADMA) and Whole Blood DNA Methylation in Early and Neovascular Age-Related Macular Degeneration: A Pilot Study.
    Current eye research, 2016, Volume: 41, Issue:1

    Topics: Aged; Aged, 80 and over; Arginine; Case-Control Studies; DNA; DNA Methylation; Female; Homocysteine; Humans; Male; Pilot Projects; Risk Factors; Wet Macular Degeneration

2016
The association between coronary atherosclerotic burden and asymmetric dimethylarginine, carotis intima media thickness and endothelial function.
    Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2014, Volume: 42, Issue:8

    Topics: Aged; Arginine; Biomarkers; Brachial Artery; Carotid Intima-Media Thickness; Cholesterol; Cholesterol, LDL; Coronary Artery Disease; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Predictive Value of Tests; Severity of Illness Index; Triglycerides

2014
Association between endothelial and platelet function markers and adiponectin in renal transplanted recipients on cyclosporine and tacrolimus immunosuppression based therapy.
    Nephrology (Carlton, Vic.), 2015, Volume: 20, Issue:6

    Topics: Adiponectin; Adult; Arginine; Biomarkers; Blood Platelets; Case-Control Studies; Cyclosporine; Drug Therapy, Combination; Endothelial Cells; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; P-Selectin; Platelet Aggregation; Platelet Function Tests; Risk Factors; Tacrolimus; Treatment Outcome; Up-Regulation; Young Adult

2015
Novel peptide chemistry in terrestrial animals: natural luciferin analogues from the bioluminescent earthworm Fridericia heliota.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2015, Mar-02, Volume: 21, Issue:10

    Topics: Animals; Arginine; Firefly Luciferin; gamma-Aminobutyric Acid; Luminescent Agents; Magnetic Resonance Spectroscopy; Oligochaeta; Peptides

2015
Investigation of subclinical atherosclerosis in psoriatic arthritis patients with minimal disease activity.
    Rheumatology international, 2015, Volume: 35, Issue:8

    Topics: Adult; Arginine; Arthritis, Psoriatic; Asymptomatic Diseases; Atherosclerosis; Brachial Artery; Cardiovascular Diseases; Carotid Arteries; Carotid Intima-Media Thickness; Cross-Sectional Studies; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Plaque, Atherosclerotic; Severity of Illness Index; Vasodilation

2015
Activation of nuclear factor erythroid 2-related factor 2 coordinates dimethylarginine dimethylaminohydrolase/PPAR-γ/endothelial nitric oxide synthase pathways that enhance nitric oxide generation in human glomerular endothelial cells.
    Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:4

    Topics: Arginine; Blotting, Western; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation; Humans; Kidney Glomerulus; NF-E2-Related Factor 2; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; PPAR gamma; Real-Time Polymerase Chain Reaction; RNA

2015
Accelerated onset of senescence of endothelial progenitor cells in patients with type 2 diabetes mellitus: role of dimethylarginine dimethylaminohydrolase 2 and asymmetric dimethylarginine.
    Biochemical and biophysical research communications, 2015, Mar-20, Volume: 458, Issue:4

    Topics: Amidohydrolases; Arginine; Cellular Senescence; Diabetes Mellitus, Type 2; Endothelial Progenitor Cells; Female; Humans; Male; Middle Aged; Sirtuin 1

2015
Serum homocysteine, asymmetric dimethyl arginine (ADMA) and other arginine-NO pathway metabolite levels in patients with psoriasis.
    Archives of dermatological research, 2015, Volume: 307, Issue:5

    Topics: Adult; Arginine; Biomarkers; Enzyme Inhibitors; Female; Homocysteine; Humans; Male; Middle Aged; Nitric Oxide; Psoriasis; Signal Transduction; Young Adult

2015
Early childhood hospitalisation with infection and subclinical atherosclerosis in adulthood: the Cardiovascular Risk in Young Finns Study.
    Atherosclerosis, 2015, Volume: 239, Issue:2

    Topics: Adult; Age of Onset; Arginine; Asymptomatic Diseases; Biomarkers; Brachial Artery; Carotid Arteries; Carotid Artery Diseases; Carotid Intima-Media Thickness; Child; Child, Preschool; Communicable Diseases; Female; Finland; Hospitalization; Humans; Infant; Infant, Newborn; Longitudinal Studies; Male; Phenotype; Prognosis; Prospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Time Factors; Vascular Stiffness; Vasodilation; Young Adult

2015
CT-1 induces angiogenesis by regulating the ADMA/DDAH Pathway.
    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2015, Volume: 159, Issue:4

    Topics: Amidohydrolases; Arginine; Cell Migration Assays; Cell Movement; Cell Proliferation; Cells, Cultured; Cytokines; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III; RNA, Messenger; Signal Transduction; Tetraspanin 24; Transfection; Vascular Endothelial Growth Factor A

2015
Asymmetric Dimethyl-L-Arginine is a Biomarker for Disease Stage and Follow-Up of Pulmonary Hypertension Associated with Congenital Heart Disease.
    Pediatric cardiology, 2015, Volume: 36, Issue:5

    Topics: Adult; Arginine; Biomarkers; Female; Follow-Up Studies; Heart Defects, Congenital; Humans; Hypertension, Pulmonary; Male; Middle Aged; Prospective Studies; Pulmonary Artery; Sildenafil Citrate; Treatment Outcome; Vascular Resistance; Vasodilator Agents; Young Adult

2015
Novel markers of endothelial dysfunction and inflammation in Behçet's disease patients with ocular involvement: epicardial fat thickness, carotid intima media thickness, serum ADMA level, and neutrophil-to-lymphocyte ratio.
    Clinical rheumatology, 2016, Volume: 35, Issue:3

    Topics: Adipose Tissue; Adult; Arginine; Behcet Syndrome; Biomarkers; Carotid Intima-Media Thickness; Cross-Sectional Studies; Echocardiography; Endothelium, Vascular; Eye; Female; Humans; Inflammation; Leukocyte Count; Lymphocytes; Male; Neutrophils; Pericardium

2016
Exercise-induced vasodilation in healthy males: A marker of reduced endothelial function.
    Scandinavian cardiovascular journal : SCJ, 2015, Volume: 49, Issue:3

    Topics: Adult; Aged; Arginine; Biomarkers; Endothelium, Vascular; Exercise; Exercise Test; Humans; Hyperemia; Inflammation; Interleukin-10; Male; Middle Aged; Plethysmography, Impedance; Statistics as Topic; Vasodilation

2015
The role of asymmetric and symmetric dimethylarginine in acute deep vein thrombosis.
    Annals of vascular surgery, 2015, Volume: 29, Issue:5

    Topics: Acute Disease; Adult; Arginine; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Treatment Outcome; Venous Thrombosis

2015
A reduction of asymmetric dimethylarginine in renal transplant recipients receiving sirolimus-based regimen.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2015, Volume: 98 Suppl 1

    Topics: Arginine; Calcineurin Inhibitors; Cross-Sectional Studies; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Sirolimus; Transplant Recipients

2015
Relationship between Dietary Approaches to Stop Hypertension score and Alternative Healthy Eating Index score with plasma asymmetrical dimethylarginine levels in patients referring for coronary angiography.
    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2015, Volume: 28, Issue:4

    Topics: Aged; Arginine; Coronary Angiography; Coronary Disease; Coronary Stenosis; Cross-Sectional Studies; Diet; Energy Intake; Female; Health Promotion; Humans; Hypertension; Iran; Male; Middle Aged

2015
Nitric oxide dysregulation in patients with heart failure: the association of depressive symptoms with L-arginine, asymmetric dimethylarginine, symmetric dimethylarginine, and isoprostane.
    Psychosomatic medicine, 2015, Volume: 77, Issue:3

    Topics: Aged; Arginine; Depression; Female; Heart Failure; Humans; Isoprostanes; Linear Models; Male; Middle Aged; Nitric Oxide; Oxidative Stress

2015
Plasma asymmetric and symmetric dimethylarginine in a rat model of endothelial dysfunction induced by acute hyperhomocysteinemia.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Amidohydrolases; Animals; Arginine; Cathepsin D; Disease Models, Animal; Endothelium, Vascular; Gene Expression Regulation; Hyperhomocysteinemia; Liver; Male; Methionine; Rats; Rats, Wistar; Ubiquitin

2015
Packed red blood cells are an abundant and proximate potential source of nitric oxide synthase inhibition.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Animals; Arginine; Catalase; Enzyme Inhibitors; Erythrocytes; Humans; Nitric Oxide; Nitric Oxide Synthase; Proteolysis; Rats; Temperature; Time Factors

2015
Interleukin-6 and asymmetric dimethylarginine are associated with platelet activation after percutaneous angioplasty with stent implantation.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Aged; Angioplasty, Balloon, Coronary; Arginine; Blood Platelets; C-Reactive Protein; Cardiovascular Diseases; Creatinine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Integrin beta3; Interleukin-6; Male; Middle Aged; Monocytes; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoprotein IIb; Risk Factors; Smoking; Stents

2015
Reduced Renal Methylarginine Metabolism Protects against Progressive Kidney Damage.
    Journal of the American Society of Nephrology : JASN, 2015, Volume: 26, Issue:12

    Topics: Acute Kidney Injury; Adult; Allografts; Amidohydrolases; Animals; Arginine; Collagen Type I; Collagen Type I, alpha 1 Chain; Female; Folic Acid; Gene Expression; Glomerular Filtration Rate; Humans; Kidney Transplantation; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Nitric Oxide; RNA, Messenger; Transaminases; Ureteral Obstruction; Uromodulin

2015
Association of advanced age with concentrations of uraemic toxins in CKD.
    Journal of nephrology, 2016, Volume: 29, Issue:1

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Arginine; beta 2-Microglobulin; Biomarkers; Blood Urea Nitrogen; Creatinine; Female; Furans; Humans; Male; Middle Aged; Multivariate Analysis; Propionates; Renal Dialysis; Renal Insufficiency, Chronic; Uremia

2016
Asymmetric dimethylarginine in somatically healthy schizophrenia patients treated with atypical antipsychotics: a case-control study.
    BMC psychiatry, 2015, Apr-03, Volume: 15

    Topics: Adult; Antipsychotic Agents; Arginine; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Humans; Male; Oxidative Stress; Schizophrenia

2015
The role of plasma triglyceride/high-density lipoprotein cholesterol ratio to predict cardiovascular outcomes in chronic kidney disease.
    Lipids in health and disease, 2015, Apr-16, Volume: 14

    Topics: Adult; Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Cholesterol, HDL; Female; Glomerular Filtration Rate; Humans; Longitudinal Studies; Male; Middle Aged; Parathyroid Hormone; Renal Insufficiency, Chronic; Retrospective Studies; Serum Albumin; Triglycerides

2015
Pleiotropic effects of fenofibrate therapy on rats with hypertriglycemia.
    Lipids in health and disease, 2015, Apr-14, Volume: 14

    Topics: Animals; Apolipoprotein A-I; Arginine; C-Reactive Protein; Cardiotonic Agents; Cholesterol, HDL; Dose-Response Relationship, Drug; Fenofibrate; Hypertriglyceridemia; Hypolipidemic Agents; Male; Malondialdehyde; Nitric Oxide; Rats; Rats, Sprague-Dawley; Triglycerides

2015
Role of asymmetric dimethylarginine in rat acute lung injury induced by acute ischemic kidney injury.
    Molecular medicine reports, 2015, Volume: 12, Issue:2

    Topics: Actins; Acute Kidney Injury; Acute Lung Injury; Animals; Arginine; Enzyme Activation; HSP27 Heat-Shock Proteins; Ischemia; Kidney; Lung; Male; p38 Mitogen-Activated Protein Kinases; Permeability; Rats, Wistar

2015
Asymmetric dimethylarginine is negatively correlated with hyperglycemia in children.
    Endocrine journal, 2015, Volume: 62, Issue:6

    Topics: Adolescent; Arginine; Biomarkers; Body Mass Index; Cardiovascular Diseases; Child; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Cardiomyopathies; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Hyperglycemia; Japan; Male; Pediatric Obesity; Risk

2015
First-Trimester Maternal Serum Levels of sFLT1, PGF and ADMA Predict Preeclampsia.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Adult; Area Under Curve; Arginine; Blood Pressure; Case-Control Studies; Demography; Female; Follow-Up Studies; Humans; Logistic Models; Placenta Growth Factor; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; Pregnancy Trimester, First; Pregnancy Trimester, Second; Prospective Studies; ROC Curve; Ultrasonography; Uterine Artery; Vascular Endothelial Growth Factor Receptor-1

2015
Atorvastatin protects endothelium by decreasing asymmetric dimethylarginine in dyslipidemia rats.
    Lipids in health and disease, 2015, May-02, Volume: 14

    Topics: Animals; Arginine; Atorvastatin; Blood Glucose; Cholesterol; Cholesterol, HDL; Creatine Kinase; Dyslipidemias; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardium; Nitric Oxide; Rats; Rats, Sprague-Dawley; Triglycerides

2015
Association of homoarginine and methylarginines with liver dysfunction and mortality in chronic liver disease.
    Amino acids, 2015, Volume: 47, Issue:9

    Topics: Adult; Aged; Arginine; Chronic Disease; Disease-Free Survival; Female; Follow-Up Studies; Homoarginine; Humans; Liver Cirrhosis; Male; Middle Aged; Retrospective Studies; Survival Rate

2015
Physical exercise reduces synthesis of ADMA, SDMA, and L-Arg.
    Frontiers in bioscience (Elite edition), 2015, 06-01, Volume: 7, Issue:3

    Topics: Arginine; Biomarkers; Coronary Artery Disease; Exercise; Female; Humans; Male; Middle Aged; Nitric Oxide

2015
S100B and ADMA in cerebral small vessel disease and cognitive dysfunction.
    Journal of the neurological sciences, 2015, Jul-15, Volume: 354, Issue:1-2

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Cerebral Small Vessel Diseases; Cognition Disorders; Female; Humans; Male; Middle Aged; S100 Calcium Binding Protein beta Subunit; Single-Blind Method

2015
The relationship between serum asymmetric dimethylarginine levels and subjective sleep quality in normotensive patients with type 2 diabetes mellitus.
    The Korean journal of internal medicine, 2015, Volume: 30, Issue:3

    Topics: Adult; Arginine; Biomarkers; Cardiovascular Diseases; Chi-Square Distribution; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Risk Factors; Sleep; Sleep Wake Disorders; Surveys and Questionnaires

2015
Effect of DDAH/ADMA/NOS regulation pathway on cavernae corporum cavernosorum rat penis of different age.
    Andrologia, 2016, Volume: 48, Issue:3

    Topics: Amidohydrolases; Animals; Arginine; Cyclic GMP; Male; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Papaverine; Penis; Rats; Rats, Sprague-Dawley

2016
Assessment of serum asymmetric dimethylarginine levels and left ventricular diastolic function in patients with ankylosing spondylitis.
    International journal of rheumatic diseases, 2017, Volume: 20, Issue:2

    Topics: Adult; Antirheumatic Agents; Arginine; Biological Products; Biomarkers; Blood Sedimentation; C-Reactive Protein; Case-Control Studies; Cross-Sectional Studies; Diastole; Disability Evaluation; Echocardiography, Doppler; Female; Humans; Male; Nitric Oxide; Spondylitis, Ankylosing; Treatment Outcome; Tumor Necrosis Factor-alpha; Ventricular Function, Left; Young Adult

2017
Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals.
    Circulation research, 2015, Jul-03, Volume: 117, Issue:2

    Topics: Animals; Arginine; Arteriosclerosis; Calcinosis; Diabetes Mellitus, Experimental; Dietary Fats; Frizzled Receptors; Gene Expression Regulation; Histones; Low Density Lipoprotein Receptor-Related Protein-6; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteopontin; Paracrine Communication; Protein Interaction Mapping; Protein-Arginine N-Methyltransferases; Receptors, Cell Surface; Receptors, LDL; Upstream Stimulatory Factors; Vascular Stiffness; Wnt Signaling Pathway

2015
Computational Study of Symmetric Methylation on Histone Arginine Catalyzed by Protein Arginine Methyltransferase PRMT5 through QM/MM MD and Free Energy Simulations.
    Molecules (Basel, Switzerland), 2015, May-29, Volume: 20, Issue:6

    Topics: Arginine; Biocatalysis; Histones; Humans; Kinetics; Methylation; Molecular Dynamics Simulation; Protein-Arginine N-Methyltransferases; Protons; Quantum Theory; S-Adenosylmethionine; Substrate Specificity; Thermodynamics

2015
The Arginine/ADMA Ratio Is Related to the Prevention of Atherosclerotic Plaques in Hypercholesterolemic Rabbits When Giving a Combined Therapy with Atorvastatine and Arginine.
    International journal of molecular sciences, 2015, May-29, Volume: 16, Issue:6

    Topics: Animals; Anticholesteremic Agents; Arginine; Atorvastatin; Cholesterol; Dietary Supplements; Hypercholesterolemia; Nitric Oxide; Nitric Oxide Synthase; Plaque, Atherosclerotic; Rabbits

2015
LC-MS/MS for the simultaneous determination of polar endogenous ADMA and CML in plasma and urine from diabetics.
    Bioanalysis, 2015, Volume: 7, Issue:10

    Topics: Arginine; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Linear Models; Lysine; Retrospective Studies; Tandem Mass Spectrometry

2015
L-citrulline for protection of endothelial function from ADMA-induced injury in porcine coronary artery.
    Scientific reports, 2015, Jun-05, Volume: 5

    Topics: Animals; Arginine; Cardiovascular Agents; Citrulline; Coronary Vessels; Cyclic GMP; Drug Evaluation, Preclinical; Endothelium, Vascular; Nitric Oxide Synthase Type III; Phosphorylation; Protein Processing, Post-Translational; Superoxides; Sus scrofa; Vascular System Injuries

2015
Heat Shock Proteins, L-Arginine, and Asymmetric Dimethylarginine Levels in Patients With Obstructive Sleep Apnea Syndrome.
    Archivos de bronconeumologia, 2015, Volume: 51, Issue:11

    Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus; Disease Susceptibility; Endothelium, Vascular; Female; Heat-Shock Proteins; Humans; Hypercholesterolemia; Hypertension; Male; Middle Aged; Obesity; Oxidative Stress; Polysomnography; Risk Factors; Sleep Apnea, Obstructive; Smoking; Turkey

2015
Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with COPD.
    The clinical respiratory journal, 2017, Volume: 11, Issue:3

    Topics: Aged; Arginine; Biomarkers; Cross-Sectional Studies; Disease Progression; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Forced Expiratory Volume; Humans; Lung; Male; Middle Aged; Nitric Oxide; Prospective Studies; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Smoking

2017
The effects of atorvastatin on antioxidant/antiinflammatory properties of HDLs in hypercholesterolemics.
    Turkish journal of medical sciences, 2015, Volume: 45, Issue:2

    Topics: Adult; Anticholesteremic Agents; Arginine; Atorvastatin; Drug Monitoring; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Inflammation; Lipoproteins, HDL; Male; Malondialdehyde; Middle Aged; Nitric Oxide; Oxidative Stress; Pyrroles; Treatment Outcome

2015
Asymmetric dimethyl arginine induces pulmonary vascular dysfunction via activation of signal transducer and activator of transcription 3 and stabilization of hypoxia-inducible factor 1-alpha.
    Vascular pharmacology, 2015, Volume: 73

    Topics: Amidohydrolases; Arginine; Calcium; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Hypertension, Pulmonary; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation Mediators; Intercellular Adhesion Molecule-1; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Synthase Type III; Pulmonary Artery; Signal Transduction; STAT3 Transcription Factor

2015
Reference intervals of plasma matrix metalloproteinases 2, 3, and 9 and serum asymmetric dimethylarginine levels.
    Scandinavian journal of clinical and laboratory investigation, 2015, Volume: 75, Issue:6

    Topics: Adult; Arginine; Female; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Middle Aged; Reference Values

2015
Veterinary Medicine and Multi-Omics Research for Future Nutrition Targets: Metabolomics and Transcriptomics of the Common Degenerative Mitral Valve Disease in Dogs.
    Omics : a journal of integrative biology, 2015, Volume: 19, Issue:8

    Topics: Animals; Arginine; Blood Glucose; Decision Trees; Dipeptides; Dogs; Glutathione Disulfide; Heart Valve Diseases; Heart Ventricles; High-Throughput Nucleotide Sequencing; Lipid Metabolism; Metabolomics; Mitral Valve; Molecular Sequence Annotation; Nutrition Assessment; Oxidative Stress; Random Allocation; Transcriptome

2015
Atrial Fibrillation Is Associated with a Marker of Endothelial Function and Oxidative Stress in Patients with Acute Myocardial Infarction.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: Aged; Aged, 80 and over; Arginine; Atrial Fibrillation; Biomarkers; Chromatography, High Pressure Liquid; Electrocardiography; Endothelium; Female; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Oxidative Stress; Risk Assessment; Risk Factors

2015
Role of the endogenous nitric oxide inhibitor asymmetric dimethylarginine (ADMA) and brain-derived neurotrophic factor (BDNF) in depression and behavioural changes: clinical and preclinical data in chronic kidney disease.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2015, Volume: 30, Issue:10

    Topics: Animals; Arginine; Brain-Derived Neurotrophic Factor; Cohort Studies; Cross-Sectional Studies; Depression; Depressive Disorder, Major; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Nephrectomy; Nitric Oxide; Nitric Oxide Synthase; Problem Behavior; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic

2015
Hyperhomocysteinemia: a missing link to dysfunctional HDL via paraoxanase-1.
    Canadian journal of physiology and pharmacology, 2015, Volume: 93, Issue:9

    Topics: Amidohydrolases; Animals; Arginine; Aryldialkylphosphatase; Atherosclerosis; Blood Pressure; Connexins; Diet, Atherogenic; Endothelium, Vascular; Fibrosis; Gap Junction alpha-4 Protein; Gap Junction alpha-5 Protein; Hyperhomocysteinemia; Lipoproteins, HDL; Male; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Ventricular Dysfunction, Left

2015
Blood pressure from childhood to adolescence in obese youths in relation to insulin resistance and asymmetric dimethylarginine.
    Journal of endocrinological investigation, 2016, Volume: 39, Issue:2

    Topics: Adolescent; Adolescent Development; Arginine; Biomarkers; Blood Pressure Monitoring, Ambulatory; Body Mass Index; Child; Child Development; Disease Progression; Female; Humans; Hypertension; Insulin Resistance; Italy; Lost to Follow-Up; Male; Pediatric Obesity; Prehypertension; Risk Factors; Severity of Illness Index

2016
Dimethylarginines as biomarkers for the kidney transplant management in methylmalonic aciduria.
    Nephrology (Carlton, Vic.), 2015, Volume: 20, Issue:8

    Topics: Adult; Allografts; Amino Acid Metabolism, Inborn Errors; Arginine; Biomarkers; Cause of Death; Disease Progression; Fatal Outcome; Humans; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Transplantation; Living Donors; Male; Pancreatitis; Predictive Value of Tests; Risk Factors; Time Factors; Treatment Outcome

2015
Serial determinations of asymmetric dimethylarginine and homocysteine during pregnancy to predict pre-eclampsia: a longitudinal study.
    BJOG : an international journal of obstetrics and gynaecology, 2015, Volume: 122, Issue:12

    Topics: Adult; Arginine; Biomarkers; Body Mass Index; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Longitudinal Studies; Pre-Eclampsia; Predictive Value of Tests; Pregnancy; Risk Factors; United Kingdom; Vitamin B Complex; Vitamin B Deficiency

2015
FoxO1 regulates asymmetric dimethylarginine via downregulation of dimethylaminohydrolase 1 in human endothelial cells and subjects with atherosclerosis.
    Atherosclerosis, 2015, Volume: 242, Issue:1

    Topics: Amidohydrolases; Arginine; Carotid Artery Diseases; Cells, Cultured; Chromatography, Liquid; Down-Regulation; Forkhead Box Protein O1; Forkhead Transcription Factors; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation, Enzymologic; Human Umbilical Vein Endothelial Cells; Humans; Metabolomics; Mutation; Signal Transduction; Transfection

2015
Asymmetric dimethylarginine in experimental breast cancer; action of Vitamin C and E.
    JPMA. The Journal of the Pakistan Medical Association, 2015, Volume: 65, Issue:8

    Topics: Animals; Antioxidants; Arginase; Arginine; Ascorbic Acid; Female; Mammary Neoplasms, Experimental; Mice; Nitric Oxide; Nitric Oxide Synthase; Vitamin E

2015
Increased Plasma Levels of Asymmetric Dimethylarginine in Nonalcoholic Fatty Liver Disease: Relation With Insulin Resistance, Inflammation, and Liver Histology.
    Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2015, Volume: 63, Issue:7

    Topics: Adult; Arginine; C-Reactive Protein; Case-Control Studies; Female; Humans; Inflammation; Insulin Resistance; Liver; Male; Middle Aged; Non-alcoholic Fatty Liver Disease

2015
The effect of nephropathy on plasma sphingosine 1-phosphate concentrations in patients with type 2 diabetes.
    Clinical biochemistry, 2015, Volume: 48, Issue:18

    Topics: Albuminuria; Apolipoproteins; Apolipoproteins M; Arginine; Biological Transport; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Lipocalins; Lysophospholipids; Male; Middle Aged; Sphingosine; Triglycerides

2015
Evaluation of ADMA-DDAH-NOS axis in specific brain areas following nitroglycerin administration: study in an animal model of migraine.
    The journal of headache and pain, 2015, Volume: 16

    Topics: Amidohydrolases; Animals; Arginine; Brain; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Migraine Disorders; Nitric Oxide Synthase Type I; Nitroglycerin; Rats; Rats, Sprague-Dawley

2015
[Interactions between markers of endothelial damage (homocysteine and asymmetric dimethylarginine) and antioxidants and B-vitamins in preeclamptic women].
    Ginecologia y obstetricia de Mexico, 2015, Volume: 83, Issue:6

    Topics: Adolescent; Adult; Antioxidants; Arginine; Biomarkers; Cross-Sectional Studies; Female; Homocysteine; Humans; Pre-Eclampsia; Pregnancy; Prospective Studies; Regression Analysis; Vitamin B Complex; Vitamin B Deficiency; Young Adult

2015
Elevated Levels of Asymmetric Dimethylarginine (ADMA) in the Pericardial Fluid of Cardiac Patients Correlate with Cardiac Hypertrophy.
    PloS one, 2015, Volume: 10, Issue:8

    Topics: Adult; Arginine; Cardiomegaly; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Pericardial Fluid; Ventricular Remodeling

2015
The relationship between neutrophil to lymphocyte ratio, endothelial function, and severity in patients with obstructive sleep apnea.
    Journal of cardiology, 2016, Volume: 67, Issue:3

    Topics: Adult; Aged; Arginine; Biomarkers; Continuous Positive Airway Pressure; Endothelial Progenitor Cells; Endothelium, Vascular; Female; Humans; Lymphocyte Count; Lymphocytes; Male; Middle Aged; Neutrophils; Nitric Oxide; Prospective Studies; Severity of Illness Index; Sleep Apnea, Obstructive

2016
Endothelial dysfunction in subjects with chronic cadmium exposure.
    The Journal of toxicological sciences, 2015, Volume: 40, Issue:5

    Topics: Arginine; Biomarkers; Cadmium Compounds; Endothelium, Vascular; Environmental Exposure; Female; Glutathione; Humans; Linear Models; Malondialdehyde; Nitrites; Thrombomodulin; Vascular Diseases

2015
Asymmetric dimethylarginine but not osteoprotegerin correlates with disease severity in patients with moderate-to-severe psoriasis undergoing anti-tumor necrosis factor-α therapy.
    The Journal of dermatology, 2016, Volume: 43, Issue:4

    Topics: Adalimumab; Adult; Anti-Inflammatory Agents; Arginine; Biological Therapy; Biomarkers; Female; Humans; Male; Middle Aged; Osteoprotegerin; Prospective Studies; Psoriasis; Resistin; Tumor Necrosis Factor-alpha

2016
Increased levels of MMP-3, MMP-9 and MPO represent predictors of in-stent restenosis, while increased levels of ADMA, LCAT, ApoE and ApoD predict bare metal stent patency.
    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2015, Volume: 159, Issue:4

    Topics: Aged; Apolipoproteins D; Apolipoproteins E; Arginine; Biomarkers; Case-Control Studies; Coronary Restenosis; Female; Graft Occlusion, Vascular; Humans; Lipoprotein(a); Male; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Middle Aged; Percutaneous Coronary Intervention; Peroxidase; Phosphatidylcholine-Sterol O-Acyltransferase; Stents; Vascular Patency

2015
Endogenous Asymmetric Dimethylarginine Pathway in High Altitude Adapted Yaks.
    BioMed research international, 2015, Volume: 2015

    Topics: Adaptation, Physiological; Altitude; Amidohydrolases; Animals; Arginine; Cattle; Hemodynamics; Lung; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III

2015
Asymmetric dimethylarginine is transported by the mitochondrial carrier SLC25A2.
    Amino acids, 2016, Volume: 48, Issue:2

    Topics: Amino Acid Transport Systems, Basic; Arginine; Biological Transport; Carrier Proteins; Cell Line, Tumor; Humans; Kidney Tubules, Proximal; Mitochondria; Mitochondrial Membranes; Transaminases

2016
Asymmetric dimethylarginine is not a good predictor of ischemia using myocardial perfusion scintigraphy.
    Turkish journal of medical sciences, 2015, Volume: 45, Issue:4

    Topics: Arginine; Coronary Artery Disease; Echocardiography; Female; Humans; Ischemia; Male; Middle Aged; Myocardial Perfusion Imaging; Predictive Value of Tests; Technetium Tc 99m Sestamibi; Tomography, Emission-Computed, Single-Photon

2015
Is left ventricular diastolic function impaired in patients with ankylosing spondylitis?
    International journal of rheumatic diseases, 2017, Volume: 20, Issue:11

    Topics: Arginine; Diastole; Humans; Spondylitis, Ankylosing; Ventricular Function, Left

2017
Asymmetric dimethylarginine predicts left atrial appendage thrombus in patients with non-valvular atrial fibrillation.
    Thrombosis research, 2015, Volume: 136, Issue:6

    Topics: Aged; Arginine; Atrial Appendage; Atrial Fibrillation; Female; Humans; Male; Middle Aged; Nitric Oxide; Thrombosis

2015
Icariin regulates PRMT/ADMA/DDAH pathway to improve endothelial function.
    Pharmacological reports : PR, 2015, Volume: 67, Issue:6

    Topics: Amidohydrolases; Animals; Aorta; Apolipoproteins E; Arginine; Flavonoids; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Knockout; Protein-Arginine N-Methyltransferases; Reactive Oxygen Species; Signal Transduction; Vasodilation

2015
Effects of captopril, telmisartan and bardoxolone methyl (CDDO-Me) in ischemia-reperfusion-induced acute kidney injury in rats: an experimental comparative study.
    Clinical and experimental pharmacology & physiology, 2016, Volume: 43, Issue:2

    Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Antioxidants; Apoptosis; Arginine; Benzimidazoles; Benzoates; Captopril; Creatine; Endothelin-1; Gene Expression Regulation; Glutathione Peroxidase; Ischemia; Kidney; Lipocalin-2; Lipocalins; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oleanolic Acid; Proto-Oncogene Proteins; Rats; Rats, Wistar; Reperfusion Injury; Sulfhydryl Compounds; Superoxide Dismutase; Telmisartan; Urea

2016
The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2016, Volume: 31, Issue:3

    Topics: Adipose Tissue; Amidohydrolases; Animals; Arginine; Blotting, Western; Cells, Cultured; Gene Expression Regulation; Male; Mice; Mice, Transgenic; Nephrectomy; Oxidative Stress; Phenotype; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Renal Insufficiency, Chronic; RNA; Signal Transduction

2016
Osteoprotegerin is Associated With Endothelial Function and Predicts Early Carotid Atherosclerosis in Patients With Coronary Artery Disease.
    International heart journal, 2015, Volume: 56, Issue:6

    Topics: Aged; Arginine; Biomarkers; Carotid Artery Diseases; Carotid Intima-Media Thickness; Coronary Angiography; Coronary Artery Disease; Early Diagnosis; Endothelium, Vascular; Female; Humans; Japan; Male; Middle Aged; Osteoprotegerin; Predictive Value of Tests; Risk Assessment; Risk Factors; Severity of Illness Index

2015
ADMA, subclinical changes and atrial fibrillation in the general population.
    International journal of cardiology, 2016, Jan-15, Volume: 203

    Topics: Adult; Aged; Arginine; Atrial Fibrillation; Biomarkers; Chromatography, Liquid; Echocardiography; Electrocardiography; Female; Germany; Humans; Male; Middle Aged; Morbidity; omega-N-Methylarginine; Oxidative Stress; Population Surveillance; Tandem Mass Spectrometry

2016
Nitric Oxide-Related Biological Pathways in Patients with Major Depression.
    PloS one, 2015, Volume: 10, Issue:11

    Topics: Adult; Arginase; Arginine; Biological Availability; Case-Control Studies; Demography; Depressive Disorder, Major; Female; Humans; Male; Middle Aged; Nitric Oxide; Psychometrics; Signal Transduction

2015
Hypertension subtypes modify metabolic response to thiazide diuretics.
    European journal of clinical investigation, 2016, Volume: 46, Issue:1

    Topics: Adiponectin; Adult; Antihypertensive Agents; Arginine; Asian People; Blood Glucose; China; Cholesterol; Cohort Studies; Diastole; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Multivariate Analysis; Prospective Studies; Sodium Chloride Symporter Inhibitors; Systole; Treatment Outcome

2016
Associations between asymmetric dimethylarginine, homocysteine, and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism (rs1801133) in rheumatoid arthritis.
    Scandinavian journal of rheumatology, 2016, Volume: 45, Issue:4

    Topics: Aged; Analysis of Variance; Arginine; Arthritis, Rheumatoid; Cohort Studies; Female; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Polymorphism, Genetic

2016
Methylarginines in Mice with Experimental Atherosclerosis.
    Bulletin of experimental biology and medicine, 2015, Volume: 160, Issue:1

    Topics: Animals; Arginine; Atherosclerosis; Cholesterol; Endothelium, Vascular; Male; Mice; Mice, Inbred CBA; Nitric Oxide Synthase; omega-N-Methylarginine; Poloxamer; Triglycerides

2015
Acetylation of asymmetric and symmetric dimethylarginine: an undercharacterized pathway of metabolism of endogenous methylarginines.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2016, Volume: 31, Issue:1

    Topics: Acetylation; Animals; Arginine; Chromatography, Liquid; Kidney; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Nephrectomy; Organ Specificity; Protein Processing, Post-Translational

2016
ADMA and arginine derivatives in relation to non-invasive vascular function in the general population.
    Atherosclerosis, 2016, Volume: 244

    Topics: Adult; Aged; Arginine; Blood Flow Velocity; Brachial Artery; Cardiovascular Diseases; Cross-Sectional Studies; Enzyme Inhibitors; Female; Germany; Humans; Male; Middle Aged; Nitric Oxide Synthase; Population Surveillance; Prevalence; Retrospective Studies; Vasodilation

2016
L-Arginine Derivatives Are Associated with the Hyperthyroid State in the General Population.
    Thyroid : official journal of the American Thyroid Association, 2016, Volume: 26, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Atherosclerosis; Cross-Sectional Studies; Female; Germany; Humans; Hyperthyroidism; Male; Middle Aged; Regression Analysis; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine; Young Adult

2016
Changes in Biliary Levels of Arginine and its Methylated Derivatives after Hepatic Ischaemia/Reperfusion.
    Basic & clinical pharmacology & toxicology, 2016, Volume: 119, Issue:1

    Topics: Alanine Transaminase; Alkaline Phosphatase; Amidohydrolases; Amino Acid Transport Systems, Basic; Animals; Arginine; Aspartate Aminotransferases; Bile; Citrulline; Liver; Liver Diseases; Male; Nitric Oxide; Rats; Rats, Wistar; Reperfusion Injury; RNA, Messenger

2016
Whole-body synthesis of L-homoarginine in pigs and rats supplemented with L-arginine.
    Amino acids, 2016, Volume: 48, Issue:4

    Topics: Animal Feed; Animals; Arginine; Body Weight; Creatinine; Dietary Supplements; Female; Glycine max; Homoarginine; Male; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Swine; Zea mays

2016
Low urinary citrulline/arginine ratio associated with blood pressure abnormalities and arterial stiffness in childhood chronic kidney disease.
    Journal of the American Society of Hypertension : JASH, 2016, Volume: 10, Issue:2

    Topics: Adolescent; Arginine; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Child; Citrulline; Female; Humans; Hypertension; Male; Nitric Oxide; Nitric Oxide Synthase; Pulse Wave Analysis; Renal Insufficiency, Chronic; Taiwan; Vascular Remodeling; Vascular Stiffness

2016
Effect of inflammation by acute sepsis on intact fibroblast growth factor 23 (iFGF23) and asymmetric dimethyl arginine (ADMA) in CKD patients.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2016, Volume: 26, Issue:1

    Topics: Arginine; Biomarkers; Case-Control Studies; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Glomerular Filtration Rate; Historically Controlled Study; Hospitalization; Humans; Inflammation; Inflammation Mediators; Kidney; Longitudinal Studies; Male; Middle Aged; Renal Insufficiency, Chronic; Sepsis; Time Factors; Treatment Outcome

2016
ADMA--a Possible Marker for Early Therapeutic Outcome in Acute Stroke.
    Clinical laboratory, 2015, Volume: 61, Issue:11

    Topics: Aged; Arginine; Biomarkers; Female; Humans; Male; Middle Aged; Stroke; Thrombolytic Therapy

2015
Evaluation of Endothelial (dys)Function, Left Ventricular Structure and Function in Patients with Chronic Kidney Disease.
    Current vascular pharmacology, 2016, Volume: 14, Issue:4

    Topics: Aged; Arginine; Biomarkers; Case-Control Studies; Echocardiography, Doppler; Endothelium, Vascular; Female; Humans; Hypertrophy, Left Ventricular; Male; Middle Aged; Nitric Oxide Synthase Type III; Renal Dialysis; Renal Insufficiency, Chronic; Stroke Volume; Treatment Outcome; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling

2016
Assessment of heat shock proteins and endothelial dysfunction in acute pulmonary embolism.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2016, Volume: 27, Issue:4

    Topics: Acute Disease; Adult; Aged; Arginine; Biomarkers; Case-Control Studies; Endothelium, Vascular; Female; Gene Expression; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Male; Middle Aged; Molecular Chaperones; Oxidative Stress; Oxygen; Pulmonary Artery; Pulmonary Embolism

2016
Neopterin, homocysteine, and ADMA levels during and after urticaria attack.
    Turkish journal of medical sciences, 2015, Volume: 45, Issue:6

    Topics: Adult; Aged; Arginine; Biomarkers; Emergency Service, Hospital; Female; Homocysteine; Humans; Male; Middle Aged; Neopterin; Prospective Studies; Urticaria; Young Adult

2015
Apolipoprotein E polymorphism modulation of asymmetric dimethylarginine in hypertensive patients is determined by renal function.
    Lipids in health and disease, 2016, Jan-20, Volume: 15

    Topics: Alleles; Apolipoproteins E; Arginine; Demography; Female; Humans; Hypertension; Kidney; Kidney Function Tests; Logistic Models; Male; Middle Aged; Polymorphism, Genetic; Racial Groups; Renal Replacement Therapy

2016
DDAH1 deficiency promotes intracellular oxidative stress and cell apoptosis via a miR-21-dependent pathway in mouse embryonic fibroblasts.
    Free radical biology & medicine, 2016, Volume: 92

    Topics: Amidohydrolases; Animals; Apoptosis; Arginine; Embryo, Mammalian; Endothelial Cells; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation; Mice; MicroRNAs; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Signal Transduction; Superoxide Dismutase

2016
Nebivolol ameliorates asymmetric dimethylarginine-induced vascular response in rat aorta via β3 adrenoceptor-mediated mechanism.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2016, Volume: 38, Issue:2

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic beta-1 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-3 Receptor Antagonists; Animals; Aorta; Arginine; Butoxamine; Enzyme Inhibitors; In Vitro Techniques; Nebivolol; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Pindolol; Rats; Receptors, Adrenergic, beta-3

2016
Does the ADMA/DDAH/NO pathway modulate early regression of left ventricular hypertrophy with esmolol?
    Medical hypotheses, 2016, Volume: 87

    Topics: Adrenergic beta-1 Receptor Antagonists; Amidohydrolases; Animals; Antihypertensive Agents; Arginine; Humans; Hypertension; Hypertrophy, Left Ventricular; Models, Cardiovascular; Nitric Oxide; Propanolamines; Rats; Rats, Inbred SHR; Risk Factors; Signal Transduction; Ventricular Remodeling

2016
Asymmetric dimethylarginine (ADMA) elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbidly obese humans.
    The Journal of physiology, 2016, 06-01, Volume: 594, Issue:11

    Topics: Adipose Tissue; Adult; Aged; Animals; Arginase; Arginine; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Insulin Resistance; Male; Middle Aged; Obesity, Morbid; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Up-Regulation; Vasodilation

2016
[THE CLINICAL LABORATORY MARKERS OF ATHEROSCLEROSIS IN PATIENTS WITH ATHEROTHROMBOTIC STROKE].
    Klinicheskaia laboratornaia diagnostika, 2015, Volume: 60, Issue:10

    Topics: Aged; Aged, 80 and over; Arginine; Atherosclerosis; Biomarkers; C-Reactive Protein; Carotid Stenosis; Case-Control Studies; Female; Humans; Male; Middle Aged; Phospholipases A2; Pregnancy-Associated Plasma Protein-A; Stroke

2015
Increased asymmetric dimethylarginine levels in severe transient tachypnea of the newborn.
    Journal of perinatology : official journal of the California Perinatal Association, 2016, Volume: 36, Issue:6

    Topics: Arginine; Blood Pressure; Female; Humans; Infant, Newborn; Male; Nitric Oxide; Nitric Oxide Synthase; Pulmonary Artery; Severity of Illness Index; Statistics as Topic; Transient Tachypnea of the Newborn

2016
N-methylnicotinamide protects against endothelial dysfunction and attenuates atherogenesis in apolipoprotein E-deficient mice.
    Molecular nutrition & food research, 2016, Volume: 60, Issue:7

    Topics: Acetylcholine; Amidohydrolases; Animals; Aorta; Arginine; Atherosclerosis; Cholesterol, Dietary; Cyclic GMP; Diet, High-Fat; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Niacinamide; Nitric Oxide; Promoter Regions, Genetic; Vasodilation

2016
IL-4 promotes asymmetric dimethylarginine accumulation, oxo-nitrative stress, and hypoxic response-induced mitochondrial loss in airway epithelial cells.
    The Journal of allergy and clinical immunology, 2016, Volume: 138, Issue:1

    Topics: Amidohydrolases; Apoptosis; Arginine; Asthma; Calpain; Cell Line; Cells, Cultured; Cytokines; Epithelial Cells; Humans; Hypoxia; Inflammation Mediators; Interleukin-4; Mitochondria; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Proteolysis; Reactive Oxygen Species; Respiratory Mucosa

2016
Serum trans fatty acids, asymmetric dimethylarginine and risk of acute myocardial infarction and mortality in patients with suspected coronary heart disease: a prospective cohort study.
    Lipids in health and disease, 2016, Feb-27, Volume: 15

    Topics: Aged; Arginine; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Trans Fatty Acids

2016
Ageing/Menopausal Status in Healthy Women and Ageing in Healthy Men Differently Affect Cardiometabolic Parameters.
    International journal of medical sciences, 2016, Volume: 13, Issue:2

    Topics: Adult; Aging; Arginine; Blood; Body Weight; Female; Humans; Interleukin-6; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Postmenopause; Premenopause; Protein Carbonylation; Risk Factors; Triglycerides; Tumor Necrosis Factor-alpha

2016
The effect of varicocoelectomy on the relationship of oxidative stress in peripheral and internal spermatic vein with semen parameters.
    Andrology, 2016, Volume: 4, Issue:3

    Topics: Adult; Arginine; Glutathione; Humans; Infertility, Male; Male; Oxidative Stress; Reactive Oxygen Species; Semen Analysis; Superoxide Dismutase; Treatment Outcome; Varicocele; Young Adult

2016
The separation and analysis of symmetric and asymmetric dimethylarginine and other hydrophilic isobaric compounds using aqueous normal phase chromatography.
    Journal of chromatography. A, 2016, Apr-08, Volume: 1441

    Topics: Arginine; Case-Control Studies; Chromatography, Liquid; Humans; Hydrophobic and Hydrophilic Interactions; Silicates; Tuberculosis, Pulmonary; Water

2016
Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells.
    American journal of respiratory cell and molecular biology, 2016, Volume: 55, Issue:2

    Topics: Animals; Arginine; Carrier Proteins; Disease Models, Animal; Endothelial Cells; Genes, Dominant; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Lung; Mitochondria; Nitric Oxide Synthase Type III; Phosphorylation; Proteasome Endopeptidase Complex; Protein Binding; Proteolysis; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Regional Blood Flow; Sheep; Ubiquitination

2016
ADMA: a specific biomarker for pathologic progress in diabetic microvascular complications?
    Biomarkers in medicine, 2016, Volume: 10, Issue:4

    Topics: Adult; Aged; Area Under Curve; Arginine; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Logistic Models; Lysine; Male; Middle Aged; Odds Ratio; Prediabetic State; ROC Curve; Tandem Mass Spectrometry

2016
Intercellular Adhesion Molecule and Endogenous NOS Inhibitor: Asymmetric Dimethylarginine in Pregnant Women with Gestational Diabetes Mellitus.
    Journal of diabetes research, 2016, Volume: 2016

    Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Diabetes, Gestational; Enzyme-Linked Immunosorbent Assay; Female; Humans; Intercellular Adhesion Molecule-1; Pregnancy; Young Adult

2016
Soluble receptor and gene polymorphism for AGE: relationship with obesity and cardiovascular risks.
    Pediatric research, 2016, Volume: 80, Issue:1

    Topics: Adolescent; Alleles; Arginine; Atherosclerosis; Biomarkers; Blood Pressure; Cardiovascular Diseases; Carotid Intima-Media Thickness; Case-Control Studies; Cross-Sectional Studies; Female; Humans; Lipids; Male; Pediatric Obesity; Polymorphism, Genetic; Receptor for Advanced Glycation End Products; Regression Analysis; Risk Factors

2016
Asymmetric dimethylarginine (ADMA) treatment induces apoptosis in cultured rat mesangial cells via endoplasmic reticulum stress activation.
    Cell biology international, 2016, Volume: 40, Issue:6

    Topics: Animals; Apoptosis; Arginine; Caspase 3; Cell Line, Tumor; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Membrane Potential, Mitochondrial; Membrane Proteins; Mesangial Cells; Protein Serine-Threonine Kinases; Rats; Signal Transduction; Stress, Physiological

2016
DDAH1 plays dual roles in PM2.5 induced cell death in A549 cells.
    Biochimica et biophysica acta, 2016, Volume: 1860, Issue:12

    Topics: A549 Cells; Amidohydrolases; Arginine; Cell Death; Gene Expression Regulation; Humans; Mitogen-Activated Protein Kinases; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Oxidative Stress; Particle Size; Particulate Matter; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction

2016
Relationship between FEV
    Aging clinical and experimental research, 2017, Volume: 29, Issue:2

    Topics: Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Endothelium, Vascular; Female; Forced Expiratory Volume; Humans; Inflammation; Interleukin-6; Italy; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Risk Factors; Statistics as Topic; Vascular Stiffness

2017
Association between Body Mass Index, Asymmetric Dimethylarginine and Risk of Cardiovascular Events and Mortality in Norwegian Patients with Suspected Stable Angina Pectoris.
    PloS one, 2016, Volume: 11, Issue:3

    Topics: Angina, Stable; Arginine; Body Mass Index; Female; Humans; Male; Middle Aged; Myocardial Infarction; Nitrogen Oxides; Norway; Risk Factors

2016
Relevance of uric acid and asymmetric dimethylarginine for modeling cardiovascular risk prediction in chronic kidney disease patients.
    International urology and nephrology, 2016, Volume: 48, Issue:7

    Topics: Academic Medical Centers; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Cause of Death; Cohort Studies; Female; Humans; Kaplan-Meier Estimate; Kidney Failure, Chronic; Kidney Function Tests; Male; Middle Aged; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Assessment; Severity of Illness Index; Survival Analysis; Uric Acid

2016
The "Rise-Peak-Fall" Pattern of Time Dependency of the Cardiovascular Pleiotropic Effects of Treatment With Low-dose Atorvastatin, Losartan, and a Combination Thereof in Rats.
    Journal of cardiovascular pharmacology, 2016, Volume: 68, Issue:1

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Arginine; Atorvastatin; Cardiovascular System; Carrier Proteins; CD40 Antigens; Coronary Circulation; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isolated Heart Preparation; Losartan; Male; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Rats, Wistar; Time Factors; Vasodilation

2016
Are increased oxidative stress and asymmetric dimethylarginine levels associated with masked hypertension?
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2016, Volume: 38, Issue:3

    Topics: Adult; Age Factors; Antioxidants; Arginine; Blood Pressure; Blood Pressure Determination; Body Mass Index; Female; Humans; Lipoproteins, LDL; Male; Masked Hypertension; Middle Aged; Oxidants; Oxidative Stress; Predictive Value of Tests; Risk Factors; Statistics as Topic

2016
Osteoprotegerin, RANKL, ADMA, and Fetuin-A serum levels in children with type I diabetes mellitus.
    Pediatric diabetes, 2017, Volume: 18, Issue:4

    Topics: Adolescent; alpha-2-HS-Glycoprotein; Arginine; Biomarkers; Cardiovascular Diseases; Child; Cohort Studies; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Cardiomyopathies; Enzyme-Linked Immunosorbent Assay; Female; Glycated Hemoglobin; Greece; Humans; Male; Osteoprotegerin; RANK Ligand; Reproducibility of Results

2017
An asymmetrically dimethylarginated nuclear 90 kDa protein (p90aDMA) induced by interleukin (IL)-2, IL-4 or IL-6 in the tumor microenvironment is selectively degraded by autophagy.
    International journal of oncology, 2016, Volume: 48, Issue:6

    Topics: Arginine; Autophagy; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Interleukin-2; Interleukin-4; Interleukin-6; MCF-7 Cells; Molecular Weight; Nuclear Proteins; Protein Processing, Post-Translational; Sirolimus; Tumor Microenvironment; Uterine Cervical Neoplasms

2016
Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency.
    Journal of inherited metabolic disease, 2016, Volume: 39, Issue:3

    Topics: Adolescent; Adult; Amino Acids; Arginase; Arginine; Case-Control Studies; Child; Child, Preschool; Female; Glycine; Humans; Infant; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Phenotype; Retrospective Studies; Urea Cycle Disorders, Inborn; Young Adult

2016
(-)-Epigallocatechin Gallate Inhibits Asymmetric Dimethylarginine-Induced Injury in Human Brain Microvascular Endothelial Cells.
    Neurochemical research, 2016, Volume: 41, Issue:8

    Topics: Antioxidants; Apoptosis; Arginine; Brain; Catechin; Cell Survival; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Microvessels

2016
Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNFα/NF-κB response.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, Apr-19, Volume: 113, Issue:16

    Topics: Animals; Arginine; Cell Line; Humans; Methylation; Mice; Mice, Knockout; Molecular Dynamics Simulation; NF-kappa B p50 Subunit; Protein-Arginine N-Methyltransferases; Repressor Proteins; Signal Transduction; Transcription Factor RelA; Tumor Necrosis Factor-alpha

2016
Serum levels of homocysteine, asymmetric dimethylarginine and nitric oxide in patients with Parkinson's disease.
    Acta clinica Belgica, 2016, Volume: 71, Issue:2

    Topics: Aged; Arginine; Female; Homocysteine; Humans; Hyperhomocysteinemia; Immunoassay; Male; Middle Aged; Nitric Oxide; Parkinson Disease

2016
Plasma concentrations of three methylated arginines, endogenous nitric oxide synthase inhibitors, in schizophrenic patients undergoing antipsychotic drug treatment.
    Psychiatry research, 2016, Apr-30, Volume: 238

    Topics: Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Arginine; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; omega-N-Methylarginine; Schizophrenia; Treatment Outcome; Young Adult

2016
The hydrogen sulfide releasing compounds ATB-346 and diallyl trisulfide attenuate streptozotocin-induced cognitive impairment, neuroinflammation, and oxidative stress in rats: involvement of asymmetric dimethylarginine.
    Canadian journal of physiology and pharmacology, 2016, Volume: 94, Issue:7

    Topics: Allyl Compounds; Animals; Arginine; Cognitive Dysfunction; Hydrogen Sulfide; Inflammation; Inflammation Mediators; Male; Maze Learning; Naproxen; Oxidative Stress; Rats; Rats, Wistar; Streptozocin; Sulfides

2016
Asymmetric Dimethylarginine versus Proton Pump Inhibitors Usage in Patients with Stable Coronary Artery Disease: A Cross-Sectional Study.
    International journal of molecular sciences, 2016, Apr-15, Volume: 17, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Arginine; Coronary Artery Disease; Cross-Sectional Studies; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Humans; Male; Middle Aged; Omeprazole; Pantoprazole; Peptic Ulcer; Proton Pump Inhibitors; Treatment Outcome

2016
Increased Asymmetric Dimethylarginine and Ischemia-Modified Albumin Levels in Obstructive Sleep Apnea.
    Respiratory care, 2016, Volume: 61, Issue:8

    Topics: Adult; Arginine; Biomarkers; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Polysomnography; Serum Albumin; Serum Albumin, Human; Severity of Illness Index; Sleep Apnea, Obstructive

2016
Asymmetric dimethylarginine and heart-type fatty acid-binding protein 3 are risk markers of cardiotoxicity in carbon monoxide poisoning cases in Zagazig university hospitals.
    Human & experimental toxicology, 2017, Volume: 36, Issue:3

    Topics: Adult; Arginine; Biomarkers; Carbon Monoxide Poisoning; Carboxyhemoglobin; Case-Control Studies; Egypt; Electrocardiography; Fatty Acid Binding Protein 3; Fatty Acid-Binding Proteins; Female; Heart; Humans; Male; Risk Factors; Young Adult

2017
Detrimental effects of a bout of physical exercise on circulating endogenous inhibitors of endothelial function in patients with coronary artery disease.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2017, Volume: 18, Issue:8

    Topics: Adult; Aged; Arginine; Biomarkers; Case-Control Studies; Coronary Artery Disease; Echocardiography; Exercise; Exercise Test; Female; Humans; Male; Middle Aged; Nitric Oxide Synthase; Risk Factors; Young Adult

2017
High salt medium activates RhoA/ROCK and downregulates eNOS expression via the upregulation of ADMA.
    Molecular medicine reports, 2016, Volume: 14, Issue:1

    Topics: Arginine; Cell Line; Cell Survival; Cells, Cultured; Gene Expression; Gene Expression Regulation; Humans; Nitric Oxide Synthase Type III; Protein-Arginine N-Methyltransferases; Repressor Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA Interference; RNA, Messenger; RNA, Small Interfering; Sodium Chloride, Dietary

2016
NO synthesis from arginine is favored by α-linolenic acid in mice fed a high-fat diet.
    Amino acids, 2016, Volume: 48, Issue:9

    Topics: alpha-Linolenic Acid; Animals; Arginine; Dietary Fats; Liver; Male; Mice; Nitric Oxide; PPAR alpha; Signal Transduction

2016
Effects of ADMA on gene expression and metabolism in serum-starved LoVo cells.
    Scientific reports, 2016, 05-16, Volume: 6

    Topics: Apoptosis; Arginine; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Culture Media; Fatty Acids; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Male; Metabolome; Metabolomics; Nucleic Acids; Oligonucleotide Array Sequence Analysis

2016
Determination of Asymmetric and Symmetric Dimethylarginine in Serum from Patients with Chronic Kidney Disease: UPLC-MS/MS versus ELISA.
    Toxins, 2016, 05-13, Volume: 8, Issue:5

    Topics: Arginine; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Humans; Renal Insufficiency, Chronic; Tandem Mass Spectrometry

2016
Oncological miR-182-3p, a Novel Smooth Muscle Cell Phenotype Modulator, Evidences From Model Rats and Patients.
    Arteriosclerosis, thrombosis, and vascular biology, 2016, Volume: 36, Issue:7

    Topics: Animals; Arginine; Carotid Artery Diseases; Carotid Artery Injuries; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Coronary Artery Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Gene Expression Profiling; Gene Expression Regulation; Humans; Male; MicroRNAs; Muscle, Smooth, Vascular; Myelin and Lymphocyte-Associated Proteolipid Proteins; Myocytes, Smooth Muscle; Neointima; Oligonucleotide Array Sequence Analysis; Phenotype; Rats, Sprague-Dawley; RNA Interference; Signal Transduction; Transfection; Vascular Remodeling

2016
High Levels of Methylarginines Were Associated With Increased Mortality in Patients With Severe Sepsis.
    Shock (Augusta, Ga.), 2016, Volume: 46, Issue:4

    Topics: Aged; Arginine; Female; Humans; Male; Middle Aged; Nitric Oxide; Proportional Hazards Models; Sepsis; Shock, Septic

2016
Serum L-arginine and dimethylarginine levels in migraine patients with brain white matter lesions.
    Cephalalgia : an international journal of headache, 2017, Volume: 37, Issue:6

    Topics: Adult; Aged; Arginine; Biomarkers; Female; Humans; Male; Middle Aged; Migraine Disorders; White Matter; Young Adult

2017
Asymmetric dimethylarginine and related metabolites in exhaled breath condensate of children with cystic fibrosis.
    The clinical respiratory journal, 2018, Volume: 12, Issue:1

    Topics: Adolescent; Arginine; Biomarkers; Breath Tests; Child; Chromatography, High Pressure Liquid; Cystic Fibrosis; Disease Progression; Exhalation; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Mass Spectrometry; Prospective Studies

2018
Comparison of Asymmetric Dimethylarginine Levels Between Stages Three, Four, and Five Non-dialysis of Chronic Kidney Disease.
    Acta medica Indonesiana, 2016, Volume: 48, Issue:1

    Topics: Adult; Arginine; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Renal Insufficiency, Chronic

2016
Early regression of coronary artery remodeling with esmolol and DDAH/ADMA pathway in hypertensive rats.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2016, Volume: 39, Issue:10

    Topics: Adrenergic beta-1 Receptor Antagonists; Amidohydrolases; Animals; Arginine; Blood Pressure; Coronary Vessels; Dose-Response Relationship, Drug; Hypertension; Male; Myocytes, Smooth Muscle; Nitric Oxide; Propanolamines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Serotonin; Vascular Remodeling

2016
N-Acetylcysteine Prevents Programmed Hypertension in Male Rat Offspring Born to Suramin-Treated Mothers.
    Biology of reproduction, 2016, Volume: 95, Issue:1

    Topics: Acetylcysteine; Animals; Arginine; Blood Pressure; Female; Fetal Development; Hydrogen Sulfide; Hypertension; Kidney; Male; Nitric Oxide; Pre-Eclampsia; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Suramin

2016
Asymmetric dimethylarginine, related arginine derivatives, and incident atrial fibrillation.
    American heart journal, 2016, Volume: 176

    Topics: Aged; Arginine; Atrial Fibrillation; Biomarkers; Cohort Studies; Female; Humans; Incidence; Male; Middle Aged; Oxidative Stress; Proportional Hazards Models; Reproducibility of Results; Statistics as Topic

2016
Endothelin 1, ADMA and SDMA in pregnancies with obstetric and thrombotic antiphospholipid syndrome.
    Journal of reproductive immunology, 2016, Volume: 116

    Topics: Adult; Antiphospholipid Syndrome; Arginine; Chronic Disease; Endothelin-1; Endothelium, Vascular; Female; Humans; Hypertension; Pre-Eclampsia; Pregnancy; Prognosis; Thrombosis; Young Adult

2016
Increased ADMA levels are associated with poor pulmonary outcome in preterm neonates.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2017, Volume: 30, Issue:7

    Topics: Arginine; Biomarkers; Birth Weight; Bronchopulmonary Dysplasia; Female; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Male; Prognosis; Pulmonary Surfactants; Respiration, Artificial; Respiratory Distress Syndrome, Newborn

2017
Elevated parathyroid hormone predicts high asymmetric dimethylarginine (ADMA) concentrations in obese diabetic patients.
    Diabetes & metabolism, 2016, Volume: 42, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Diabetes Mellitus; Female; Humans; Linear Models; Male; Middle Aged; Obesity; Parathyroid Hormone

2016
Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension?
    Pulmonary medicine, 2016, Volume: 2016

    Topics: Altitude Sickness; Amidohydrolases; Animals; Arginine; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Lung; Male; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Pulmonary Circulation; Rats; Rats, Wistar; Signal Transduction; Time Factors; Vascular Resistance

2016
Hypoxia causes increased monocyte nitric oxide synthesis which is mediated by changes in dimethylarginine dimethylaminohydrolase 2 expression in animal and human models of normobaric hypoxia.
    Nitric oxide : biology and chemistry, 2016, 08-31, Volume: 58

    Topics: Adolescent; Adult; Amidohydrolases; Animals; Arginine; Cell Hypoxia; Humans; Hypoxia; Macrophages, Peritoneal; Male; Mice, Knockout; Middle Aged; Monocytes; Nitrates; Nitric Oxide; Nitrites; Young Adult

2016
Upregulation of CBS/H2S system contributes to asymmetric dimethylarginine-triggered protection against the neurotoxicity of glutamate to PC12 cells by inhibiting NOS/NO pathway.
    Experimental cell research, 2016, 08-01, Volume: 346, Issue:1

    Topics: Animals; Arginine; Cystathionine beta-Synthase; Glutamic Acid; Hydrogen Sulfide; Neuroprotection; Neuroprotective Agents; Neurotoxins; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; PC12 Cells; Rats; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Up-Regulation

2016
Elevated plasma ADMA contributes to development of endothelial dysfunction in children with acute lymphoblastic leukemia.
    Postepy higieny i medycyny doswiadczalnej (Online), 2016, Jun-01, Volume: 70, Issue:0

    Topics: Adolescent; Arginine; Cardiovascular Diseases; Child; Child, Preschool; Endothelial Cells; Endothelium-Dependent Relaxing Factors; Enzyme Inhibitors; Female; Humans; Infant; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors

2016
MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters.
    Molecular and cellular biochemistry, 2016, Volume: 419, Issue:1-2

    Topics: Amino Acid Transport Systems, Basic; Animals; Arginine; Choline; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Male; Methionine; Rats; Rats, Wistar

2016
ASYMMETRIC DIMETHYLARGININE LEVELS AND ATHEROSCLEROSIS MARKERS IN CUSHING SYNDROME.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2016, Volume: 22, Issue:9

    Topics: Adult; Ankle Brachial Index; Arginine; Atherosclerosis; Biomarkers; C-Reactive Protein; Carotid Intima-Media Thickness; Case-Control Studies; Cushing Syndrome; Female; Humans; Male; Middle Aged; Risk Factors

2016
Relationship of asymmetric dimethylarginine (ADMA) with extent and functional severity of coronary atherosclerosis.
    International journal of cardiology, 2016, Oct-01, Volume: 220

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Coronary Angiography; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Severity of Illness Index

2016
Serum asymmetric dimethylarginine and arginine levels predict microvascular and macrovascular complications in type 2 diabetes mellitus.
    Diabetes/metabolism research and reviews, 2017, Volume: 33, Issue:2

    Topics: Adolescent; Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Humans; Male; Middle Aged; Oxidative Stress; Prognosis; Prospective Studies; Risk Factors; Young Adult

2017
Asymmetric dimethylarginine (ADMA): will be or will not be a new revolutionary biomarker of bronchial asthma?
    Minerva medica, 2015, Volume: 106, Issue:5 Suppl 1

    Topics: Adult; Arginine; Asthma; Biomarkers; Case-Control Studies; Child; Enzyme Inhibitors; Evidence-Based Medicine; Exhalation; Humans; Phenotype; Predictive Value of Tests; Sensitivity and Specificity; Severity of Illness Index; Spirometry

2015
The transporter and permeability interactions of asymmetric dimethylarginine (ADMA) and L-arginine with the human blood-brain barrier in vitro.
    Brain research, 2016, 10-01, Volume: 1648, Issue:Pt A

    Topics: Arginine; Blood-Brain Barrier; Cationic Amino Acid Transporter 1; Cell Line; Cell Survival; Enzyme Inhibitors; Humans; In Vitro Techniques; Interferon-gamma; Nitric Oxide; Ornithine; Permeability; Reactive Oxygen Species; Sucrose; Tumor Necrosis Factor-alpha

2016
Effect of cholesterol lowering treatment on plasma markers of endothelial dysfunction in chronic kidney disease.
    Journal of pharmaceutical and biomedical analysis, 2016, Sep-10, Volume: 129

    Topics: Allantoin; Anticholesteremic Agents; Arginine; Biomarkers; Cholesterol; Endothelium; Ezetimibe; Female; Humans; Inflammation; Kynurenine; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Renal Insufficiency, Chronic; Simvastatin; Uric Acid

2016
[Effect of asymmetrical dimethylarginine for predicting pro-thrombotic risk in atrial fibrillation].
    Zhonghua yi xue za zhi, 2016, Jul-12, Volume: 96, Issue:26

    Topics: Arginine; Atrial Fibrillation; Cardiovascular Diseases; Heart Atria; Humans; Stereoisomerism; Thrombosis

2016
Vascular peroxidase 1 up regulation by angiotensin II attenuates nitric oxide production through increasing asymmetrical dimethylarginine in HUVECs.
    Journal of the American Society of Hypertension : JASH, 2016, Volume: 10, Issue:9

    Topics: Amidohydrolases; Angiotensin II; Animals; Aorta; Arginine; Cells, Cultured; Endothelium, Vascular; Gene Knockdown Techniques; Hemeproteins; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Peroxide; Hypertension; Hypochlorous Acid; Male; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxidases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Recombinant Proteins; RNA, Small Interfering; Up-Regulation

2016
Arginines Plasma Concentration and Oxidative Stress in Mild to Moderate COPD.
    PloS one, 2016, Volume: 11, Issue:8

    Topics: Age Factors; Aged; Aged, 80 and over; Arginine; Aryldialkylphosphatase; Biomarkers; Case-Control Studies; Female; Forced Expiratory Volume; Humans; Linear Models; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Severity of Illness Index; Sex Factors; Taurine

2016
Endothelial Nitric Oxide Synthase Prevents Heparanase Induction and the Development of Proteinuria.
    PloS one, 2016, Volume: 11, Issue:8

    Topics: Albumins; Animals; Arginine; Doxorubicin; Enzyme Induction; Gene Expression Regulation, Enzymologic; Glucuronidase; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type III; Proteinuria

2016
Marker of Endothelial Dysfunction Asymmetric Dimethylarginine Is Elevated in HIV Infection but Not Associated With Subclinical Atherosclerosis.
    Journal of acquired immune deficiency syndromes (1999), 2016, Dec-15, Volume: 73, Issue:5

    Topics: Adult; Arginine; Atherosclerosis; Biomarkers; Cross-Sectional Studies; Endothelial Cells; Female; HIV Infections; Humans; Lipopolysaccharide Receptors; Male; Middle Aged; Plasma

2016
The correlation of serum asymmetric dimethylarginine and anti-Müllerian hormone in primary dysmenorrhea.
    The Kaohsiung journal of medical sciences, 2016, Volume: 32, Issue:8

    Topics: Anti-Mullerian Hormone; Arginine; Demography; Dysmenorrhea; Female; Humans; Linear Models; Pain Measurement; Young Adult

2016
Asymmetrical dimethyl arginine in type 2 diabetic patients with coronary artery disease.
    JPMA. The Journal of the Pakistan Medical Association, 2016, Volume: 66, Issue:8

    Topics: Adult; Arginine; Blood Glucose; Case-Control Studies; Coronary Artery Disease; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged; Triglycerides

2016
Risk factors for chronic kidney disease do not influence the serum levels of asymmetric dimethylarginine in HIV-1-infected patients without significant renal disease.
    Polskie Archiwum Medycyny Wewnetrznej, 2016, Aug-18, Volume: 126, Issue:9

    Topics: Adult; Aged; Anti-HIV Agents; Arginine; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Renal Insufficiency, Chronic; Risk Factors; Young Adult

2016
Increased Bronchial Hyperresponsiveness and Higher Asymmetric Dimethylarginine Levels after Fetal Growth Restriction.
    American journal of respiratory cell and molecular biology, 2017, Volume: 56, Issue:1

    Topics: Anthropometry; Arginine; Biomarkers; Bronchial Hyperreactivity; Child; Demography; Female; Fetal Growth Retardation; Humans; Infant, Newborn; Inflammation Mediators; Lung; Male; Methacholine Chloride; Premature Birth; Respiratory Function Tests; Solubility

2017
Prediction of pre-eclampsia combining NGAL and other biochemical markers with Doppler in the first and/or second trimester of pregnancy. A pilot study.
    European journal of obstetrics, gynecology, and reproductive biology, 2016, Volume: 205

    Topics: Adult; Arginine; Biomarkers; Female; Humans; Lipocalin-2; Matrix Metalloproteinase 9; Pilot Projects; Placenta Growth Factor; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Pregnancy-Associated Plasma Protein-A; Ultrasonography, Doppler, Pulsed; Vascular Endothelial Growth Factor Receptor-1

2016
Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016, Volume: 30, Issue:12

    Topics: Animals; Arginine; Cyclooxygenase 2; Drug Combinations; Endothelium; Enzyme Inhibitors; Humans; Ibuprofen; Kidney; Male; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Substrate Specificity

2016
Short-term esmolol attenuates remodeling of the thoracic aorta in hypertensive rats by decreasing concentrations of ADMA down-regulated by oxidative stress.
    European journal of pharmacology, 2016, Nov-15, Volume: 791

    Topics: Animals; Aorta, Thoracic; Arginine; Blood Pressure; Down-Regulation; Heart Rate; Male; Oxidative Stress; Propanolamines; Protein Carbonylation; Rats; Rats, Inbred SHR; Tensile Strength; Vascular Remodeling

2016
Modulation of circulating endothelial progenitor cells by erythropoiesis-stimulating agents in patients with chronic kidney disease stage G5 and 5D
.
    Clinical nephrology, 2016, Volume: 86 (2016), Issue:11

    Topics: Adult; Arginine; Biomarkers; C-Reactive Protein; Cell Count; Darbepoetin alfa; Endothelial Progenitor Cells; Erythropoietin; Female; Hematinics; Humans; Kidney Failure, Chronic; Male; Matrix Metalloproteinase 2; Middle Aged; Prospective Studies; Recombinant Proteins; Renal Dialysis; Vascular Endothelial Growth Factor A

2016
The prediction roles of asymmetric dimethyl-arginine, adiponectin and apelin for macroangiopathy in patients with impaired glucose regulation.
    Annales d'endocrinologie, 2016, Volume: 77, Issue:6

    Topics: Adiponectin; Aged; Apelin; Arginine; Atherosclerosis; Blood Glucose; Coronary Disease; Female; Glucose Intolerance; Glucose Tolerance Test; Humans; Insulin Resistance; Intercellular Signaling Peptides and Proteins; Male; Middle Aged; Prediabetic State; Prognosis

2016
Asymmetric dimethylarginine: a risk indicator or pathogenic factor?
    Polskie Archiwum Medycyny Wewnetrznej, 2016, 09-28, Volume: 126, Issue:9

    Topics: Arginine; HIV Infections; HIV-1; Humans; Renal Insufficiency, Chronic

2016
Nebivolol suppresses asymmetric dimethylarginine and attenuates cyclosporine-induced nephrotoxicity and endothelial dysfunction in rats.
    Pharmacological reports : PR, 2016, Volume: 68, Issue:6

    Topics: Acute Kidney Injury; Adrenergic beta-1 Receptor Agonists; Animals; Arginine; Cyclosporine; Dose-Response Relationship, Drug; Endothelium, Vascular; Immunosuppressive Agents; Male; Nebivolol; Nitric Oxide Synthase Type II; Organ Culture Techniques; Oxidative Stress; Rats; Rats, Wistar

2016
Asymmetric dimethylarginine predicts the risk of contrast-induced acute kidney injury in patients undergoing cardiac catheterization.
    Atherosclerosis, 2016, Volume: 254

    Topics: Acute Kidney Injury; Aged; Arginine; Cardiac Catheterization; Contrast Media; Coronary Angiography; Female; Humans; Male; Middle Aged; Nitric Oxide; Prospective Studies; Risk Factors; ROC Curve

2016
Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2.
    Scientific reports, 2016, 10-18, Volume: 6

    Topics: Aminoisobutyric Acids; Animals; Arginine; Cardiovascular Diseases; Cell Line; Diabetes Mellitus, Type 2; Gene Expression Regulation; Hepatocyte Nuclear Factor 4; Humans; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Risk; RNA, Small Interfering; Transaminases

2016
Increased plasma asymmetric dimethylarginine is associated with cognitive deficits in patients with schizophrenia.
    Psychiatry research, 2016, Dec-30, Volume: 246

    Topics: Adult; Arginine; Biomarkers; Cognition Disorders; Cognitive Dysfunction; Female; Humans; Male; Neuropsychological Tests; Schizophrenia; Young Adult

2016
Higher serum asymmetric dimethylarginine is related to higher risk of heart failure in the EPIC-Potsdam study.
    Amino acids, 2017, Volume: 49, Issue:1

    Topics: Adult; Aged; Arginine; Biomarkers; Feeding Behavior; Female; Germany; Heart Failure; Humans; Male; Middle Aged; Myocardial Infarction; Prognosis; Proportional Hazards Models; Prospective Studies; Risk

2017
12-months metabolic changes among gender dysphoric individuals under cross-sex hormone treatment: a targeted metabolomics study.
    Scientific reports, 2016, 11-11, Volume: 6

    Topics: Adult; Amino Acids; Anthropometry; Arginine; Body Composition; Energy Metabolism; Fasting; Female; Gender Dysphoria; Gonadal Steroid Hormones; Humans; Lipid Metabolism; Male; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Principal Component Analysis; Sex Characteristics; Sex Reassignment Procedures

2016
l-Arginine Pathway Metabolites Predict Need for Intra-operative Shunt During Carotid Endarterectomy.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2016, Volume: 52, Issue:6

    Topics: Aged; Anaerobiosis; Area Under Curve; Arginine; Biomarkers; Blood Gas Analysis; Blood-Brain Barrier; Capillary Permeability; Carotid Stenosis; Cerebrovascular Circulation; Constriction; Endarterectomy, Carotid; Female; Humans; Jugular Veins; Lactic Acid; Male; Middle Aged; Pilot Projects; Predictive Value of Tests; Prospective Studies; Radial Artery; Reproducibility of Results; Risk Factors; ROC Curve; S100 Calcium Binding Protein beta Subunit; Time Factors; Treatment Outcome

2016
Increased serum concentrations of asymmetric dimethylarginine (ADMA) in patients with early-onset coronary artery disease.
    Clinica chimica acta; international journal of clinical chemistry, 2017, Volume: 464

    Topics: Age of Onset; Arginine; Coronary Artery Disease; Coronary Vessels; Female; Humans; Male; Middle Aged; Risk

2017
Effect of l-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine on ischemic heart disease risk: A Mendelian randomization study.
    American heart journal, 2016, Volume: 182

    Topics: Arginine; Female; Genome-Wide Association Study; Humans; Male; Mediator Complex; Mendelian Randomization Analysis; Myocardial Infarction; Polymorphism, Single Nucleotide; Transaminases

2016
Endocan, TGF-beta, and ADMA as Risk Factors for Endothelial Dysfunction and Possible Vascular Disease in Patients with Subclinical Hypothyroidism.
    Annals of clinical and laboratory science, 2016, Volume: 46, Issue:6

    Topics: Adult; Arginine; Biomarkers; Demography; Endothelium, Vascular; Female; Humans; Hypothyroidism; Inflammation; Male; Neoplasm Proteins; Proteoglycans; Risk Factors; Thyroid Function Tests; Transforming Growth Factor beta; Vascular Diseases

2016
Plasma Apelin and Asymmetric Dimethylarginine (ADMA) Levels Shortly After Laparoscopic Greater Curvature Plication.
    Obesity surgery, 2017, Volume: 27, Issue:6

    Topics: Adolescent; Adult; Apelin; Arginine; Bariatric Surgery; Female; Humans; Laparoscopy; Male; Middle Aged; Obesity, Morbid; Young Adult

2017
Protective effect of tanshinone IIA against cardiac hypertrophy in spontaneously hypertensive rats through inhibiting the Cys-C/Wnt signaling pathway.
    Oncotarget, 2017, Feb-07, Volume: 8, Issue:6

    Topics: Abietanes; Animals; Arginine; Cardiomegaly; Cardiovascular Agents; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type III; Cystatin C; Disease Models, Animal; Hypertension; Male; Myocardium; NADPH Oxidase 4; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Troponin I; Wnt Signaling Pathway

2017
Evaluation of endothelial dysfunction in patients with familial Mediterranean fever: the relationship between the levels of asymmetric dimethylarginine and endocan with carotid intima-media thickness and endothelium-dependent vasodilation.
    Clinical rheumatology, 2017, Volume: 36, Issue:9

    Topics: Adult; Arginine; Atherosclerosis; Biomarkers; Carotid Intima-Media Thickness; Case-Control Studies; Endothelium, Vascular; Familial Mediterranean Fever; Female; Humans; Inflammation; Male; Neoplasm Proteins; Proteoglycans; ROC Curve; Turkey; Vasodilation; Young Adult

2017
Endothelial dysfunction in the early postoperative period after major colon cancer surgery.
    British journal of anaesthesia, 2017, Volume: 118, Issue:2

    Topics: Aged; Arginine; Colonic Neoplasms; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Nitric Oxide; Postoperative Complications; Prospective Studies; Troponin I

2017
Involvement of DDAH/ADMA/NOS/cGMP and COX-2/PTGIS/cAMP Pathways in Human Tissue Kallikrein 1 Protecting Erectile Function in Aged Rats.
    PloS one, 2017, Volume: 12, Issue:1

    Topics: Aging; Amidohydrolases; Animals; Arginine; Cyclic AMP; Cyclic GMP; Cyclooxygenase 2; Cytochrome P-450 Enzyme System; Erectile Dysfunction; Humans; Intramolecular Oxidoreductases; Male; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Penile Erection; Penis; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Recombinant Proteins; RNA, Messenger; Signal Transduction; Tissue Kallikreins

2017
Admission levels of asymmetric and symmetric dimethylarginine predict long-term outcome in patients with community-acquired pneumonia.
    Respiratory research, 2017, 01-23, Volume: 18, Issue:1

    Topics: Adult; Aged; Arginine; Biomarkers; Community-Acquired Infections; Female; Humans; Longitudinal Studies; Male; Middle Aged; Patient Admission; Pneumonia; Prevalence; Proportional Hazards Models; Risk Assessment; Risk Factors; Survival Analysis; Switzerland

2017
Increased brachial intima-media thickness is associated with circulating levels of asymmetric dimethylarginine in patients with COPD.
    International journal of chronic obstructive pulmonary disease, 2017, Volume: 12

    Topics: Aged; Arginine; Asymptomatic Diseases; Atherosclerosis; Biomarkers; Brachial Artery; Case-Control Studies; Female; Humans; Inflammation; Inflammation Mediators; Linear Models; Lung; Male; Middle Aged; Multivariate Analysis; Prognosis; Pulmonary Disease, Chronic Obstructive; Risk Assessment; Risk Factors; Sex Factors; Smoking; Spirometry; Tunica Intima; Tunica Media; Ultrasonography

2017
Investigation of Asymmetric and Symmetric Dimethylarginine Levels after Iloprost Treatment in Patients with Buerger's Disease.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2017, Volume: 53, Issue:3

    Topics: Adult; Aged; Arginine; Biomarkers; Female; Humans; Iloprost; Infusions, Intravenous; Male; Middle Aged; Thromboangiitis Obliterans; Time Factors; Treatment Outcome; Vasodilator Agents

2017
Repetitive ischemia increases myocardial dimethylarginine dimethylaminohydrolase 1 expression.
    Vascular medicine (London, England), 2017, Volume: 22, Issue:3

    Topics: Amidohydrolases; Animals; Arginine; Cell Hypoxia; Cells, Cultured; Collateral Circulation; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Dogs; Endothelial Cells; Humans; Interleukin-1beta; Myocardial Ischemia; Myocardium; Neovascularization, Physiologic; Nitric Oxide Synthase Type II; Protein-Arginine N-Methyltransferases; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor A

2017
Preservation of vascular DDAH activity contributes to the protection of captopril against endothelial dysfunction in hyperlipidemic rabbits.
    European journal of pharmacology, 2017, Mar-05, Volume: 798

    Topics: Amidohydrolases; Animals; Arginine; Captopril; Diet, High-Fat; Endothelium, Vascular; Enzyme Inhibitors; Hyperlipidemias; Male; Rabbits

2017
DdaR (PA1196) Regulates Expression of Dimethylarginine Dimethylaminohydrolase for the Metabolism of Methylarginines in Pseudomonas aeruginosa PAO1.
    Journal of bacteriology, 2017, 04-15, Volume: 199, Issue:8

    Topics: Amidohydrolases; Arginine; Bacterial Proteins; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; omega-N-Methylarginine; Pseudomonas aeruginosa; RNA Polymerase Sigma 54

2017
ADMA predicts major adverse renal events in patients with mild renal impairment and/or diabetes mellitus undergoing coronary angiography.
    Medicine, 2017, Volume: 96, Issue:6

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Contrast Media; Coronary Angiography; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Predictive Value of Tests; Proportional Hazards Models; Renal Insufficiency; Severity of Illness Index

2017
Carotid Plaque Score and Risk of Cardiovascular Mortality in the Oldest Old: Results from the TOOTH Study.
    Journal of atherosclerosis and thrombosis, 2018, Jan-01, Volume: 25, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Arginine; Cardiovascular Diseases; Carotid Stenosis; Cohort Studies; Female; Humans; Japan; Kaplan-Meier Estimate; Male; Multivariate Analysis; Proportional Hazards Models; Risk Factors; Sensitivity and Specificity; Treatment Outcome

2018
[Clinical value of ADMA in patients with pulmonary arterial hypertension combination with congenital heart disease].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2017, Jan-28, Volume: 42, Issue:1

    Topics: Adult; Arginine; Biomarkers; Echocardiography; Female; Heart Defects, Congenital; Hemodynamics; Humans; Hypertension, Pulmonary; Male; Prognosis; Sensitivity and Specificity; Sildenafil Citrate

2017
Asymmetric dimethylarginine in the assessment of febrile neutropenia in hematological patients.
    Scandinavian journal of clinical and laboratory investigation, 2017, Volume: 77, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Arginine; Bacteremia; Biomarkers; C-Reactive Protein; Febrile Neutropenia; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Prospective Studies; Shock, Septic; Stem Cell Transplantation; Transplantation, Autologous

2017
Metabolic profiling of presymptomatic Huntington's disease sheep reveals novel biomarkers.
    Scientific reports, 2017, 02-22, Volume: 7

    Topics: Amino Acids, Branched-Chain; Animals; Animals, Genetically Modified; Area Under Curve; Arginine; Biomarkers; Citrulline; Genotype; Huntington Disease; Logistic Models; Metabolomics; ROC Curve; Sheep

2017
Analysis of risk factors in patients with leukoaraiosis.
    Medicine, 2017, Volume: 96, Issue:8

    Topics: Age Factors; Aged; Arginine; Blood Chemical Analysis; Enzyme-Linked Immunosorbent Assay; Factor Analysis, Statistical; Female; Humans; Leukoaraiosis; Logistic Models; Male; Middle Aged; Risk Factors

2017
The role of L-arginine/L-homoarginine/nitric oxide pathway for aortic distensibility and intima-media thickness in stroke patients.
    Amino acids, 2017, Volume: 49, Issue:6

    Topics: Aorta; Arginine; Atherosclerosis; Endothelium, Vascular; Female; Homoarginine; Humans; Male; Middle Aged; Nitric Oxide; Stroke; Ultrasonography; Vascular Remodeling

2017
Time-course changes of nLDL-induced erectile dysfunction.
    International journal of impotence research, 2017, Volume: 29, Issue:3

    Topics: Animals; Arginine; Disease Models, Animal; Endothelium, Vascular; Erectile Dysfunction; Hyperlipidemias; Lipoproteins, LDL; Male; Nitric Oxide Synthase Type III; Rats, Wistar; Time Factors

2017
Myeloperoxidase, asymmetric dimethyl-arginine and the renin-angiotensin-aldosterone-system in cardiovascular risk patients: Cross-sectional findings from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study.
    Clinical biochemistry, 2017, Volume: 50, Issue:13-14

    Topics: Aged; Aldosterone; Arginine; Austria; Biomarkers; Cardiovascular Diseases; Cohort Studies; Coronary Angiography; Cross-Sectional Studies; Female; Follow-Up Studies; Germany; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Male; Middle Aged; Mortality; Peroxidase; Predictive Value of Tests; Prevalence; Prospective Studies; Renin-Angiotensin System; Risk Factors

2017
Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study.
    The Journal of clinical endocrinology and metabolism, 2017, 06-01, Volume: 102, Issue:6

    Topics: Aged; Arginine; Cardiovascular Diseases; Case-Control Studies; Chromatography, Liquid; Citrulline; Cohort Studies; Female; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; omega-N-Methylarginine; Ornithine; Proportional Hazards Models; Prospective Studies; Risk Factors; Stroke; Tandem Mass Spectrometry

2017
Positive correlation of airway resistance and serum asymmetric dimethylarginine level in COPD patients with systemic markers of low-grade inflammation.
    International journal of chronic obstructive pulmonary disease, 2017, Volume: 12

    Topics: Aged; Airway Resistance; Arginine; Biomarkers; Bronchodilator Agents; C-Reactive Protein; Chi-Square Distribution; Cross-Sectional Studies; Disease Progression; Female; Humans; Inflammation Mediators; Linear Models; Lung; Male; Maximal Midexpiratory Flow Rate; Middle Aged; Plethysmography, Whole Body; Pulmonary Disease, Chronic Obstructive; Surveys and Questionnaires

2017
HIV-infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation.
    BMC infectious diseases, 2017, 03-29, Volume: 17, Issue:1

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; HIV Infections; Humans; Inflammation; Male; Methylamines; Middle Aged; Risk Factors; Tandem Mass Spectrometry

2017
Asymmetric dimethylarginine and arginine metabolites in women with and without a history of gestational diabetes.
    Journal of diabetes and its complications, 2017, Volume: 31, Issue:6

    Topics: Adult; Arginine; Cardiovascular Diseases; Diabetes, Gestational; Female; Follow-Up Studies; Glucose Tolerance Test; Humans; Postpartum Period; Pregnancy; Prognosis

2017
The asymmetric dimethylarginine-mediated inhibition of nitric oxide in the rostral ventrolateral medulla contributes to regulation of blood pressure in hypertensive rats.
    Nitric oxide : biology and chemistry, 2017, Jul-01, Volume: 67

    Topics: Amidohydrolases; Angiotensin II; Animals; Arginine; Blood Pressure; Heart Rate; Kidney; Losartan; Male; Medulla Oblongata; Nitric Oxide; omega-N-Methylarginine; Protein-Arginine N-Methyltransferases; Rats, Inbred WKY; Rats, Sprague-Dawley; Sympathetic Nervous System

2017
Effect of arginine:lysine and glycine:methionine intake ratios on dyslipidemia and selected biomarkers implicated in cardiovascular disease: A study with hypercholesterolemic rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 91

    Topics: Administration, Oral; Amino Acids; Animals; Arginine; Biomarkers; Body Weight; Cardiovascular Diseases; Dyslipidemias; Glycine; Homocysteine; Hypercholesterolemia; Lipids; Liver; Lysine; Male; Methionine; Nitric Oxide; Organ Size; Rats, Wistar

2017
Association of circulatory asymmetric dimethylarginine (ADMA) with diabetic nephropathy in Asian Indians and its causative role in renal cell injury.
    Clinical biochemistry, 2017, Volume: 50, Issue:15

    Topics: Adult; Albuminuria; Animals; Arginine; Asian People; Biomarkers; Cell Line; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Fibroblasts; Glomerular Mesangium; Glycated Hemoglobin; Humans; India; Male; Middle Aged; Rats

2017
The ADMA/DDAH/NO pathway in human vein endothelial cells exposed to arsenite.
    Toxicology in vitro : an international journal published in association with BIBRA, 2017, Volume: 42

    Topics: Amidohydrolases; Arginine; Arsenites; Cell Survival; Cells, Cultured; Human Umbilical Vein Endothelial Cells; Humans; NADPH Oxidase 4; Nitric Oxide; Oxidative Stress; Protein-Arginine N-Methyltransferases; Repressor Proteins

2017
Regulation of c-Jun N-Terminal Protein Kinase (JNK) Pathway in Apoptosis of Endothelial Outgrowth Cells Induced by Asymmetric Dimethylarginine.
    Medical science monitor : international medical journal of experimental and clinical research, 2017, May-26, Volume: 23

    Topics: Anthracenes; Apoptosis; Arginine; Cell Proliferation; Cell Survival; Endothelial Cells; Flow Cytometry; Fluorescence; Humans; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Neovascularization, Physiologic; Phosphorylation; Protein Kinase Inhibitors; Staining and Labeling

2017
Evaluation of ADMA, carbonyl groups, CAT and NKA in depressed patients with and without posttraumatic stress disorder.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:4

    Topics: Adult; Arginine; Biomarkers; Catalase; Depressive Disorder, Major; Female; Gene Expression Regulation; Humans; Male; Middle Aged; Neurokinin A; Stress Disorders, Post-Traumatic

2017
Methionine metabolism and multiple sclerosis.
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2017, Volume: 22, Issue:8

    Topics: Adult; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Cysteine; Electrochemical Techniques; Female; Glutathione; Homocysteine; Humans; Male; Methionine; Middle Aged; Multiple Sclerosis

2017
Human dimethylarginine dimethylaminohydrolase 1 inhibition by proton pump inhibitors and the cardiovascular risk marker asymmetric dimethylarginine: in vitro and in vivo significance.
    Scientific reports, 2017, 06-06, Volume: 7, Issue:1

    Topics: Aged; Aged, 80 and over; Amidohydrolases; Arginine; Australia; Biomarkers; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Female; Humans; Male; Mass Spectrometry; Middle Aged; Proton Pump Inhibitors; Risk Assessment

2017
Asymmetric Dimethylarginine Induced Apoptosis and Dysfunction of Endothelial Progenitor Cells: Role of Endoplasmic Reticulum Stress Pathway.
    BioMed research international, 2017, Volume: 2017

    Topics: Apoptosis; Arginine; Cells, Cultured; eIF-2 Kinase; Endoplasmic Reticulum Stress; Endothelial Progenitor Cells; Humans; Phosphorylation; Transcription Factor CHOP

2017
Association of the -449GC and -1151AC polymorphisms in the DDAH2 gene with asymmetric dimethylarginine and erythropoietin resistance in Chinese patients on maintenance hemodialysis.
    Clinical and experimental pharmacology & physiology, 2017, Volume: 44, Issue:9

    Topics: Alleles; Amidohydrolases; Arginine; Asian People; Erythropoietin; Female; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Renal Dialysis

2017
Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice.
    Antioxidants & redox signaling, 2017, Dec-01, Volume: 27, Issue:16

    Topics: Aging; Aldosterone; Amidohydrolases; Animals; Arginine; Cell Line; Creatinine; Diabetes Mellitus, Experimental; Disease Models, Animal; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibrosis; Gene Knockout Techniques; Humans; Kidney Diseases; Kidney Tubules, Proximal; Mice

2017
Effect of Visible Light on Vasospasticity of Post-Subarachnoid Hemorrhage Cerebrospinal Fluid.
    Journal of neurological surgery. Part A, Central European neurosurgery, 2017, Volume: 78, Issue:6

    Topics: Animals; Arginine; Bilirubin; Female; Humans; Light; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oxidation-Reduction; Rats; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2017
Asymmetric Dimethylarginine Contributes to the Impaired Response to Erythropoietin in CKD-Anemia.
    Journal of the American Society of Nephrology : JASN, 2017, Volume: 28, Issue:9

    Topics: Aged; Amidohydrolases; Anemia; Animals; Arginine; Cytokines; Drug Resistance; Erythrocyte Indices; Erythrocytes; Erythropoietin; Female; Gene Expression; Hematinics; Hematocrit; Hemoglobins; Humans; Male; Mice; Middle Aged; Muscle Proteins; Nephrectomy; Plasma; Receptors, Erythropoietin; Renal Insufficiency, Chronic

2017
Paraoxonase-1 and myeloperoxidase correlate with vascular biomarkers in overweight patients with newly diagnosed untreated hyperlipidaemia.
    VASA. Zeitschrift fur Gefasskrankheiten, 2017, Volume: 46, Issue:5

    Topics: Adult; Aged; Arginine; Aryldialkylphosphatase; Biomarkers; C-Reactive Protein; Case-Control Studies; CD40 Ligand; Female; Humans; Hyperlipidemias; Intercellular Adhesion Molecule-1; Lipoproteins, LDL; Male; Middle Aged; Overweight; Peroxidase; Predictive Value of Tests; Vascular Cell Adhesion Molecule-1

2017
Association between vitamin D status and asymmetric dimethylarginine (ADMA) concentration in the Korean elderly population.
    Maturitas, 2017, Volume: 102

    Topics: Aged; Aged, 80 and over; Arginine; Asian People; Biomarkers; Cardiovascular Diseases; Cross-Sectional Studies; Female; Humans; Longitudinal Studies; Male; Middle Aged; Vitamin D; Vitamin D Deficiency

2017
Renalase Assessment With Regard to Kidney Function, Lipid Disturbances, and Endothelial Dysfunction Parameters in Stable Renal Transplant Recipients.
    Progress in transplantation (Aliso Viejo, Calif.), 2017, Volume: 27, Issue:2

    Topics: Adult; Antihypertensive Agents; Arginine; C-Reactive Protein; Case-Control Studies; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Creatinine; Cross-Sectional Studies; Endothelium, Vascular; Female; Glomerular Filtration Rate; Hemoglobins; Humans; Hypertension; Intercellular Adhesion Molecule-1; Kidney Transplantation; Male; Middle Aged; Monoamine Oxidase; Renal Insufficiency, Chronic; Severity of Illness Index; Vascular Cell Adhesion Molecule-1

2017
Energy regulation in newly diagnosed TB with chronic energy deficiency: free fatty acids and RBP4.
    Asia Pacific journal of clinical nutrition, 2017, Volume: 26, Issue:Suppl 1

    Topics: Adolescent; Adult; Arginine; Body Mass Index; Cross-Sectional Studies; Energy Metabolism; Fatty Acids, Nonesterified; Female; Humans; Male; Malnutrition; Middle Aged; Retinol-Binding Proteins, Plasma; Tuberculosis; Young Adult

2017
Importance of endothelial dysfunction biomarkers in patients with Crimean-Congo hemorrhagic fever.
    Journal of medical virology, 2017, Volume: 89, Issue:12

    Topics: Adult; Aged; Arginine; Biomarkers; Cytokines; Endothelin-1; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Hemorrhage; Hemorrhagic Fever Virus, Crimean-Congo; Hemorrhagic Fever, Crimean; Humans; Kinetics; Male; Middle Aged; Prognosis; Prospective Studies; ROC Curve; Thrombomodulin; Turkey; von Willebrand Factor

2017
The prognostic biomarker L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B.
    Scientific reports, 2017, 07-06, Volume: 7, Issue:1

    Topics: Amino Acid Transport Systems, Basic; Arginine; Biological Transport, Active; Cationic Amino Acid Transporter 1; Gene Expression; HEK293 Cells; Homoarginine; Humans; Kinetics; Protein Isoforms; Substrate Specificity; Transgenes

2017
Physical activity - related changes in ADMA and vWF levels in patients with type 2 diabetes: A preliminary study.
    Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 2017, Volume: 26, Issue:4

    Topics: Adult; Arginine; Cholesterol, HDL; Diabetes Mellitus, Type 2; Exercise; Female; Humans; Male; Middle Aged; von Willebrand Factor

2017
Metabolism and distribution of pharmacological homoarginine in plasma and main organs of the anesthetized rat.
    Amino acids, 2017, Volume: 49, Issue:12

    Topics: Amidinotransferases; Animals; Arginine; Glycine; Guanidinoacetate N-Methyltransferase; Half-Life; Homoarginine; Humans; Kidney; Lipid Peroxidation; Malondialdehyde; Models, Animal; Nitric Oxide Synthase; Pilot Projects; Rats; Rats, Sprague-Dawley; Takotsubo Cardiomyopathy; Tissue Distribution

2017
Increased plasma asymmetric dimethylarginine level is associated with ascending aorta dilatation: a case-control study.
    Kardiologia polska, 2017, Volume: 75, Issue:10

    Topics: Aged; Aorta; Aortic Diseases; Arginine; Case-Control Studies; Cross-Sectional Studies; Dilatation, Pathologic; Female; Humans; Male; Middle Aged; ROC Curve

2017
A new key player in VEGF-dependent angiogenesis in human hepatocellular carcinoma: dimethylarginine dimethylaminohydrolase 1.
    Angiogenesis, 2017, Volume: 20, Issue:4

    Topics: Aged; Amidohydrolases; Arginine; Carcinoma, Hepatocellular; Cell Hypoxia; Female; Hep G2 Cells; Humans; Liver Neoplasms; Male; Neovascularization, Pathologic; Nitric Oxide; Nitric Oxide Synthase Type II; Vascular Endothelial Growth Factor A

2017
Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction.
    Basic research in cardiology, 2017, 08-17, Volume: 112, Issue:5

    Topics: Amidohydrolases; Animals; Arginine; Atrial Natriuretic Factor; Disease Models, Animal; Fibrosis; Genetic Predisposition to Disease; Hypertrophy, Left Ventricular; Male; Mice, Knockout; Myocytes, Cardiac; Nitric Oxide; Phenotype; Signal Transduction; Tyrosine; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling

2017
Influence on serum asymmetric dimethylarginine (ADMA) concentrations of human paraoxonase 1 polymorphism (Q192R) and exposure to polycyclic aromatic hydrocarbons (PAHs) in Mexican women, a gene-environment interaction.
    Chemosphere, 2017, Volume: 186

    Topics: Adult; Alleles; Arginine; Aryldialkylphosphatase; Biomarkers; Cardiovascular Diseases; Creatinine; Environmental Exposure; Environmental Pollutants; Female; Gene Frequency; Gene-Environment Interaction; Genetic Predisposition to Disease; Genotype; Humans; Mexico; Polycyclic Aromatic Hydrocarbons; Polymorphism, Genetic; Pyrenes; Risk Factors

2017
Resveratrol prevents the combined maternal plus postweaning high-fat-diets-induced hypertension in male offspring.
    The Journal of nutritional biochemistry, 2017, Volume: 48

    Topics: Animals; Arginine; Blood Pressure; Diet, High-Fat; Female; Hypertension; Male; Maternal Nutritional Physiological Phenomena; Oxidative Stress; Pregnancy; Rats, Sprague-Dawley; Renin-Angiotensin System; Resveratrol; Stilbenes; Weaning

2017
Asymmetric dimethylarginine and symmetric dimethylarginine prospectively relates to carotid wall thickening in black men: the SABPA study.
    Amino acids, 2017, Volume: 49, Issue:11

    Topics: Adult; Arginine; Black People; Cardiovascular Diseases; Carotid Intima-Media Thickness; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Regression Analysis; South America; White People

2017
Effects of propolis, caffeic acid phenethyl ester, and pollen on renal injury in hypertensive rat: An experimental and theoretical approach.
    Cell biochemistry and function, 2017, Volume: 35, Issue:6

    Topics: Animals; Antioxidants; Arginine; Aryldialkylphosphatase; Binding Sites; Caffeic Acids; Glutathione Reductase; Half-Life; Hypertension; Kidney Diseases; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; NF-kappa B; Oxidative Stress; Phenylethyl Alcohol; Pollen; Propolis; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley

2017
Systemic vascular resistance and endogenous inhibitors of nitric oxide synthesis in early- compared to late-onset preeclampsia: preliminary findings.
    Hypertension in pregnancy, 2017, Volume: 36, Issue:3

    Topics: Adult; Arginine; Case-Control Studies; Female; Humans; Pre-Eclampsia; Pregnancy; Vascular Resistance; Young Adult

2017
Asymmetric Dimethylarginine Predicts Long-Term Outcome in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.
    Lung, 2017, Volume: 195, Issue:6

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Disease Progression; Female; Humans; Male; Middle Aged; Prognosis; Proportional Hazards Models; Pulmonary Disease, Chronic Obstructive; Risk Factors; Severity of Illness Index; Survival Rate; Switzerland; Time Factors

2017
Asymmetric dimethylarginine downregulates sarco/endoplasmic reticulum calcium‑ATPase 3 and induces endoplasmic reticulum stress in human umbilical vein endothelial cells.
    Molecular medicine reports, 2017, Volume: 16, Issue:5

    Topics: Apoptosis; Arginine; Calcium; Caspase 3; Cells, Cultured; Down-Regulation; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Endoribonucleases; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Human Umbilical Vein Endothelial Cells; Humans; Membrane Proteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Transcription Factor CHOP

2017
Sub-therapeutic doses of fluvastatin and valsartan are more effective than therapeutic doses in providing beneficial cardiovascular pleiotropic effects in rats: A proof of concept study.
    Vascular pharmacology, 2017, Volume: 99

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Arginine; Blood Pressure; Cholesterol; Coronary Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Indoles; Male; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Rats, Wistar; Receptor, Endothelin A; Time Factors; Valsartan; Vasodilation

2017
Blood asymmetric dimethylarginine and nitrite/nitrate concentrations in short-stature children born small for gestational age with and without growth hormone therapy.
    The Journal of international medical research, 2018, Volume: 46, Issue:2

    Topics: Arginine; Biomarkers; Body Height; Case-Control Studies; Child; Child, Preschool; Dwarfism; Female; Growth Hormone; Humans; Infant, Newborn; Infant, Small for Gestational Age; Longitudinal Studies; Male; Nitrates; Nitrites

2018
Inverse relations of serum phosphatidylcholines and lysophosphatidylcholines with vascular damage and heart rate in patients with atherosclerosis.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2018, Volume: 28, Issue:1

    Topics: Aged; Angiography, Digital Subtraction; Arginine; Biomarkers; Case-Control Studies; Coronary Artery Disease; Cross-Sectional Studies; Endothelium, Vascular; Heart Rate; Humans; Lysophosphatidylcholines; Male; Metabolomics; Middle Aged; Peripheral Arterial Disease; Phosphatidylcholines; Pulse Wave Analysis; Vascular Stiffness

2018
Spontaneous variability of pre-dialysis concentrations of uremic toxins over time in stable hemodialysis patients.
    PloS one, 2017, Volume: 12, Issue:10

    Topics: Aged; Aged, 80 and over; Analysis of Variance; Arginine; beta 2-Microglobulin; Creatinine; Female; Hemodialysis Solutions; Hippurates; Humans; Indican; Male; Middle Aged; Observer Variation; Phosphorus; Renal Dialysis; Renal Insufficiency, Chronic; Toxins, Biological; Urea; Uric Acid

2017
Time-Dependent Production of Endothelium-Related Biomarkers is Affected Differently in Hemorrhagic and Septic Shocks.
    Inflammation, 2018, Volume: 41, Issue:1

    Topics: Animals; Antioxidants; Arginine; Biomarkers; Blood Pressure; Disease Models, Animal; Endothelial Cells; Hydrogen Sulfide; Male; Nitric Oxide; Rats, Wistar; Resuscitation; Shock, Hemorrhagic; Shock, Septic; Time Factors

2018
Association of serum asymmetric dimethylarginine, homocysteine, and l-arginine concentrations during early pregnancy with hypertensive disorders of pregnancy.
    Clinica chimica acta; international journal of clinical chemistry, 2017, Volume: 475

    Topics: Adult; Area Under Curve; Arginine; Biomarkers; Body Mass Index; Case-Control Studies; Female; Gestational Age; Homocysteine; Humans; Logistic Models; Nitric Oxide; Overweight; Parity; Pre-Eclampsia; Pregnancy; Risk Factors

2017
Diclofenac but not celecoxib improves endothelial function in rheumatoid arthritis: A study in adjuvant-induced arthritis.
    Atherosclerosis, 2017, Volume: 266

    Topics: Animals; Aorta, Thoracic; Arginase; Arginine; Arthritis, Experimental; Biological Factors; Blood Pressure; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Endothelium, Vascular; Freund's Adjuvant; In Vitro Techniques; Male; NADPH Oxidases; Nitric Oxide Synthase Type III; Phosphorylation; Rats, Inbred Lew; Vasodilation; Vasodilator Agents

2017
Opposing effects of rheumatoid arthritis and low dose prednisolone on arginine metabolomics.
    Atherosclerosis, 2017, Volume: 266

    Topics: Administration, Oral; Aged; Arginine; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Chromatography, Liquid; Drug Administration Schedule; Endothelium, Vascular; Female; Glucocorticoids; Homoarginine; Humans; Male; Mass Spectrometry; Metabolomics; Middle Aged; Prednisolone; Time Factors; Treatment Outcome

2017
Independent Association of Plasma Hydroxysphingomyelins With Physical Function in the Atherosclerosis Risk in Communities (ARIC) Study.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2018, 07-09, Volume: 73, Issue:8

    Topics: Aged; Arginine; Atherosclerosis; Cross-Sectional Studies; Female; Hand Strength; Humans; Linear Models; Male; Phosphatidylcholines; Physical Fitness; Risk Factors; Sphingomyelins; Walking Speed

2018
Impaired Arginine Metabolism Coupled to a Defective Redox Conduit Contributes to Low Plasma Nitric Oxide in Polycystic Ovary Syndrome.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 43, Issue:5

    Topics: Amidohydrolases; Arginine; Argininosuccinate Lyase; Cationic Amino Acid Transporter 1; Female; Humans; Hydrogen Peroxide; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Oxidation-Reduction; Polycystic Ovary Syndrome; Protein-Arginine N-Methyltransferases; Repressor Proteins

2017
Relationship between asymmetric dimethylarginine, nitrite and genetic polymorphisms: Impact on erectile dysfunction therapy.
    Nitric oxide : biology and chemistry, 2017, Dec-01, Volume: 71

    Topics: Amidohydrolases; Arginine; Biomarkers; Erectile Dysfunction; Humans; Male; Nitrites; Phosphodiesterase 5 Inhibitors; Polymorphism, Genetic; Sildenafil Citrate

2017
Elevated plasma asymmetric dimethylarginine levels in children with beta-thalassemia major may be an early marker for endothelial dysfunction.
    Hematology (Amsterdam, Netherlands), 2018, Volume: 23, Issue:5

    Topics: Adolescent; Arginine; beta-Thalassemia; Biomarkers; C-Reactive Protein; Child; Child, Preschool; Endothelium; Female; Humans; Intercellular Adhesion Molecule-1; Male; P-Selectin; Serum Amyloid P-Component; Vascular Cell Adhesion Molecule-1

2018
ADMA reduction does not protect mice with streptozotocin-induced diabetes mellitus from development of diabetic nephropathy.
    Atherosclerosis. Supplements, 2017, Volume: 30

    Topics: Albuminuria; Amidohydrolases; Animals; Arginine; Cell Proliferation; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Progression; Down-Regulation; Genetic Predisposition to Disease; Glomerular Mesangium; Glomerulonephritis; Hydrolysis; Kidney; Male; Mice, Inbred C57BL; Mice, Transgenic; Phenotype; Streptozocin

2017
Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y⁺LAT2 Carrier-Mediated Loss.
    International journal of molecular sciences, 2017, Nov-02, Volume: 18, Issue:11

    Topics: Amidohydrolases; Amino Acid Transport System y+; Ammonia; Animals; Arginine; Astrocytes; Cell Line; Cells, Cultured; Fusion Regulatory Protein 1, Light Chains; Nitric Oxide; Protein-Arginine N-Methyltransferases; Rats; Rats, Wistar

2017
Symmetric dimethylarginine (SDMA) outperforms asymmetric dimethylarginine (ADMA) and other methylarginines as predictor of renal and cardiovascular outcome in non-dialysis chronic kidney disease.
    Clinical research in cardiology : official journal of the German Cardiac Society, 2018, Volume: 107, Issue:3

    Topics: Aged; Arginine; Biomarkers; Cardiovascular Diseases; Chromatography, Liquid; Disease Progression; Female; Germany; Humans; Incidence; Male; Middle Aged; omega-N-Methylarginine; Prognosis; Renal Dialysis; Renal Insufficiency, Chronic; Risk Assessment; Risk Factors

2018
Elevated Levels of ADMA Are Associated with Lower DDAH2 and Higher PRMT1 in LPS-Induced Endometritis Rats.
    Inflammation, 2018, Volume: 41, Issue:1

    Topics: Amidohydrolases; Animals; Arginine; Dinoprost; Disease Models, Animal; Down-Regulation; Endometriosis; Female; Interleukin-6; Lipopolysaccharides; Peroxidase; Protein-Arginine N-Methyltransferases; Rats, Wistar; Reactive Oxygen Species; Tumor Necrosis Factor-alpha; Up-Regulation; Uterus

2018
Erythropoietin reduces collagen deposition after myocardial infarction but does not improve cardiac function.
    Canadian journal of physiology and pharmacology, 2018, Volume: 96, Issue:6

    Topics: Animals; Apoptosis; Arginine; Collagen; Diastole; Erythropoietin; Glutathione; Heart; Hematocrit; Hemoglobins; Male; Myocardial Infarction; Myocardium; Oxidative Stress; Rats

2018
Effects of betaine supplementation on nitric oxide metabolism, atherosclerotic parameters, and fatty liver in guinea pigs fed a high cholesterol plus methionine diet.
    Nutrition (Burbank, Los Angeles County, Calif.), 2018, Volume: 45

    Topics: Animals; Arginine; Atherosclerosis; Betaine; Cholesterol; Cholesterol, Dietary; Diet, High-Fat; Dietary Supplements; Fatty Liver; Guinea Pigs; Hyperlipidemias; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methionine; Nitric Oxide; Tyrosine

2018
New Oxidative Stress Markers Useful in the Diagnosis of Acute Appendicitis in Children: Thiol/Disulfide Homeostasis and the Asymmetric Dimethylarginine Level.
    Pediatric emergency care, 2020, Volume: 36, Issue:8

    Topics: Adolescent; Antioxidants; Appendicitis; Arginine; Biomarkers; C-Reactive Protein; Case-Control Studies; Child; Disulfides; Female; Homeostasis; Humans; Male; Oxidative Stress; Sulfhydryl Compounds

2020
Dimethylarginine dimethylaminohydrolase-1 (DDAH1) is frequently upregulated in prostate cancer, and its overexpression conveys tumor growth and angiogenesis by metabolizing asymmetric dimethylarginine (ADMA).
    Angiogenesis, 2018, Volume: 21, Issue:1

    Topics: Amidohydrolases; Animals; Arginine; Cell Movement; Cell Proliferation; Fibroblast Growth Factor 2; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-8; Male; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasm Transplantation; Neovascularization, Pathologic; Nitric Oxide; Nitric Oxide Synthase Type II; PC-3 Cells; Platelet Endothelial Cell Adhesion Molecule-1; Prostatic Neoplasms; Signal Transduction; Up-Regulation; Vascular Endothelial Growth Factor A

2018
Testosterone Deficiency Causes Endothelial Dysfunction via Elevation of Asymmetric Dimethylarginine and Oxidative Stress in Castrated Rats.
    The journal of sexual medicine, 2017, Volume: 14, Issue:12

    Topics: Animals; Arginine; Castration; Endothelium; Erectile Dysfunction; Humans; Male; Nitric Oxide; Oxidative Stress; Penile Erection; Penis; Rats; Rats, Wistar; Testosterone

2017
Relation of Serum ADMA, Apelin-13 and LOX-1 Levels with Inflammatory and Echocardiographic Parameters in Hemodialysis Patients.
    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2018, Volume: 22, Issue:2

    Topics: Arginine; Biomarkers; C-Reactive Protein; Echocardiography; Enzyme-Linked Immunosorbent Assay; Female; Humans; Inflammation; Intercellular Signaling Peptides and Proteins; Lymphocytes; Male; Middle Aged; Neutrophils; Renal Dialysis; Scavenger Receptors, Class E

2018
The prognostic value of asymmetric dimethylarginine in patients with cardiac syndrome X.
    PloS one, 2017, Volume: 12, Issue:12

    Topics: Aged; Arginine; Endothelium, Vascular; Female; Humans; Male; Metabolic Syndrome; Middle Aged; Prognosis

2017
Role of DDAH/ADMA pathway in TGF-β1-mediated activation of hepatic stellate cells.
    Molecular medicine reports, 2018, Volume: 17, Issue:2

    Topics: Amidohydrolases; Animals; Arginine; Cell Proliferation; Collagen Type I; Hepatic Stellate Cells; Male; MAP Kinase Signaling System; Rats; Signal Transduction; Transforming Growth Factor beta1

2018
Distinct Roles of Endothelial Dysfunction and Inflammation in Intracranial Atherosclerotic Stroke.
    European neurology, 2017, Volume: 77, Issue:3-4

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Aged; Arginine; Biomarkers; Endothelium; Female; Humans; Inflammation; Intracranial Arteriosclerosis; Male; Middle Aged; Stroke

2017
Protein arginine methyltransferase expression and activity during myogenesis.
    Bioscience reports, 2018, 02-28, Volume: 38, Issue:1

    Topics: Animals; Arginine; Cell Differentiation; Gene Expression Regulation, Developmental; Histones; Mice; Muscle Cells; Muscle Development; Muscle Fibers, Skeletal; Muscle, Skeletal; Protein-Arginine N-Methyltransferases

2018
Inverse correlation between maternal plasma asymmetric dimethylarginine (ADMA) and birthweight percentile in women with impaired placental perfusion: circulating ADMA as an NO-independent indicator of fetal growth restriction?
    Amino acids, 2018, Volume: 50, Issue:2

    Topics: Adult; Arginine; Biomarkers; Birth Weight; Female; Fetal Growth Retardation; Fetus; Gestational Age; Humans; Infant, Newborn; Male; Nitrates; Nitric Oxide; Nitrites; Placenta; Pre-Eclampsia; Pregnancy; Pregnancy Outcome

2018
Amniotic Fluid Arginine from Gestational Weeks 13 to 15 Is a Predictor of Birth Weight, Length, and Head Circumference.
    Nutrients, 2017, Dec-14, Volume: 9, Issue:12

    Topics: Adult; Amniotic Fluid; Arginine; Birth Weight; Dietary Supplements; Female; Fetal Growth Retardation; Humans; Infant; Male; Middle Aged; Nitric Oxide; Pregnancy; Pregnancy Trimesters; Young Adult

2017
Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2018, 06-01, Volume: 33, Issue:6

    Topics: Animals; Arginine; Disease Models, Animal; Glutathione Peroxidase; Heart Diseases; Mice; Mice, Knockout; Platelet Aggregation; Reactive Oxygen Species; Renal Insufficiency, Chronic; Thrombosis; Ventricular Dysfunction, Left

2018
Anti-Atherogenic Activity of Polyphenol-Rich Extract from Bee Pollen.
    Nutrients, 2017, Dec-18, Volume: 9, Issue:12

    Topics: Angiotensin II; Animals; Arginine; Atherosclerosis; Bees; Cholesterol; Coronary Artery Disease; Diet, High-Fat; Dose-Response Relationship, Drug; Female; Hypercholesterolemia; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Peptidyl-Dipeptidase A; Pollen; Polyphenols

2017
Serum Concentrations of New Predictive Cardiovascular Disease Biomarkers in Mexican Women Exposed to Lead.
    Archives of environmental contamination and toxicology, 2018, Volume: 74, Issue:2

    Topics: Adiponectin; Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Cardiovascular Diseases; Chemokines; Cross-Sectional Studies; Environmental Exposure; Fatty Acid-Binding Proteins; Female; Humans; Intercellular Signaling Peptides and Proteins; Lead; Male; Mexico; Middle Aged

2018
Global arginine bioavailability ratio is decreased in patients with major depressive disorder.
    Journal of affective disorders, 2018, 03-15, Volume: 229

    Topics: Adult; Aged; Arginine; Biological Availability; Citrulline; Depressive Disorder, Major; Female; Humans; Male; Middle Aged; Nitric Oxide; Ornithine; Oxidative Stress; Surveys and Questionnaires; Young Adult

2018
The farnesoid X receptor agonist obeticholic acid upregulates biliary excretion of asymmetric dimethylarginine via MATE-1 during hepatic ischemia/reperfusion injury.
    PloS one, 2018, Volume: 13, Issue:1

    Topics: Animals; Antiporters; Arginine; Biliary Tract; Blotting, Western; Carrier Proteins; Chenodeoxycholic Acid; Liver Diseases; Male; Nitric Oxide Synthase; Organic Cation Transport Proteins; Protein-Arginine N-Methyltransferases; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Reperfusion Injury; RNA, Messenger; Up-Regulation

2018
Asymmetric dimethylarginine (ADMA) is identified as a potential biomarker of insulin resistance in skeletal muscle.
    Scientific reports, 2018, 02-01, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Animals; Arginine; Biomarkers; Cohort Studies; Humans; Insulin Resistance; Mice; Mice, Inbred C57BL; Middle Aged; Muscle, Skeletal; Signal Transduction

2018
Relation of asymmetrical dimethylarginine levels with renal outcomes in hypertensive patients with and without type 2 diabetes mellitus.
    Journal of diabetes and its complications, 2018, Volume: 32, Issue:3

    Topics: Aged; Albuminuria; Arginine; Biomarkers; Case-Control Studies; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Male; Middle Aged; Renal Insufficiency, Chronic

2018
Asymmetric dimethylarginine levels are associated with augmentation index across naïve untreated patients with different hypertension phenotypes.
    Journal of clinical hypertension (Greenwich, Conn.), 2018, Volume: 20, Issue:4

    Topics: Adult; Arginine; Arterial Pressure; Biomarkers; Case-Control Studies; Essential Hypertension; Female; Humans; Hypertension; Male; Masked Hypertension; Middle Aged; Pulse Wave Analysis; Risk Factors; Vascular Stiffness; White Coat Hypertension

2018
Increased Endothelial Dysfunction and Insulin Resistance in Patients with Klinefelter Syndrome.
    Endocrine, metabolic & immune disorders drug targets, 2018, Volume: 18, Issue:4

    Topics: Arginine; Biomarkers; Blood Glucose; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Cholesterol, HDL; Endothelium, Vascular; Humans; Inflammation; Inflammation Mediators; Insulin; Insulin Resistance; Klinefelter Syndrome; Male; Multivariate Analysis; Prevalence; Risk Factors; Testosterone; Turkey; Young Adult

2018
Kidney Mass Reduction Leads to l-Arginine Metabolism-Dependent Blood Pressure Increase in Mice.
    Journal of the American Heart Association, 2018, 02-25, Volume: 7, Issue:5

    Topics: Animals; Arginase; Arginine; Blood Pressure; Citrulline; Female; Kidney; Male; Mice, Inbred C57BL; Mice, Knockout; Nephrectomy; Nitric Oxide; Organ Size

2018
Serum Methylarginines and Hearing Loss in a Population-based Cohort of Older Adults.
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2018, Volume: 39, Issue:4

    Topics: Aged; Arginine; Biomarkers; Cohort Studies; Cross-Sectional Studies; Female; Hearing Loss; Humans; Male; Middle Aged

2018
Homoarginine and inhibition of human arginase activity: kinetic characterization and biological relevance.
    Scientific reports, 2018, 02-27, Volume: 8, Issue:1

    Topics: Aged; Aged, 80 and over; Agmatine; Arginase; Arginine; Cell Line; Chromatography, Liquid; Enzyme Activation; Female; Homoarginine; Humans; Kinetics; Male; Proline; Protein Isoforms; Tandem Mass Spectrometry

2018
Asymmetric dimethylarginine levels and diabetes duration: Relationship with measures of subclinical atherosclerosis and cardiac function in children and adolescents with Type 1 diabetes.
    Diabetes & vascular disease research, 2018, Volume: 15, Issue:3

    Topics: Adolescent; Adult; Arginine; Atherosclerosis; Carotid Intima-Media Thickness; Child; Diabetes Mellitus, Type 1; Echocardiography; Echocardiography, Doppler; Female; Humans; Male; Myocardium; Ventricular Function, Left; Young Adult

2018
Malaria in pregnancy alters l-arginine bioavailability and placental vascular development.
    Science translational medicine, 2018, 03-07, Volume: 10, Issue:431

    Topics: Animals; Arginine; Female; Humans; Malaria; Mice; Nitric Oxide; Placenta; Pregnancy; Pregnancy Outcome; Prospective Studies

2018
Estimation of asymmetric dimethylarginine (ADMA), placental growth factor (PLGF) and pentraxin 3 (PTX 3) in women with preeclampsia.
    Pregnancy hypertension, 2018, Volume: 14

    Topics: Adult; Arginine; Biomarkers; C-Reactive Protein; Case-Control Studies; Disease Progression; Female; Humans; India; Placenta Growth Factor; Pre-Eclampsia; Predictive Value of Tests; Pregnancy; Prospective Studies; ROC Curve; Serum Amyloid P-Component; Young Adult

2018
Serum concentrations of asymmetric and symmetric dimethylarginine are associated with mortality in acute heart failure patients.
    International journal of cardiology, 2018, 06-15, Volume: 261

    Topics: Acute Disease; Aged; Aged, 80 and over; Arginine; Biomarkers; Cohort Studies; Female; Heart Failure; Humans; Male; Mortality; Stroke Volume

2018
Asymmetric and Symmetric Dimethylarginines are Markers of Delayed Cerebral Ischemia and Neurological Outcome in Patients with Subarachnoid Hemorrhage.
    Neurocritical care, 2018, Volume: 29, Issue:1

    Topics: Adult; Aged; Arginine; Biomarkers; Brain Ischemia; Cerebral Angiography; Female; Humans; Incidence; Male; Middle Aged; Outcome Assessment, Health Care; Subarachnoid Hemorrhage

2018
Endothelium, asymmetric dimethylarginine, and atherosclerosis in chronic kidney disease.
    Polish archives of internal medicine, 2018, 03-29, Volume: 128, Issue:3

    Topics: Arginine; Atherosclerosis; Endothelium; Humans; Radial Artery; Renal Insufficiency, Chronic

2018
Asymmetric dimethylarginine as a useful risk marker of radial artery calcification in patients with advanced kidney disease.
    Polish archives of internal medicine, 2018, 03-29, Volume: 128, Issue:3

    Topics: Aged; Arginine; Biomarkers; Calcinosis; Female; Humans; Male; Middle Aged; Radial Artery; Renal Insufficiency, Chronic

2018
Association of endothelial dysfunction with cardiovascular risk factors and new-onset diabetes mellitus in patients with hypertension.
    Journal of clinical hypertension (Greenwich, Conn.), 2018, Volume: 20, Issue:5

    Topics: Aged; Arginine; Brazil; C-Reactive Protein; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus, Type 2; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Hypertension; Male; Metabolic Syndrome; Middle Aged; Nitric Oxide Synthase; Predictive Value of Tests; Prospective Studies; Risk Factors; Triglycerides

2018
Alterations in plasma L-arginine and methylarginines in heart failure and after heart transplantation.
    Scandinavian cardiovascular journal : SCJ, 2018, Volume: 52, Issue:4

    Topics: Arginine; Biomarkers; Citrulline; Endothelium, Vascular; Female; Heart Failure; Heart Transplantation; Hemodynamics; Humans; Male; Middle Aged; Nitric Oxide; Ornithine; Prospective Studies; Time Factors; Treatment Outcome

2018
Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction.
    Scientific reports, 2018, 04-30, Volume: 8, Issue:1

    Topics: Arginine; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Endothelium; Feces; Female; Gastrointestinal Microbiome; HIV Infections; Humans; Inflammation; Kynurenine; Male; Metabolism; Middle Aged; Neopterin; Risk Factors; RNA, Ribosomal, 16S; Tryptophan

2018
Oxysterols Increase Inflammation, Lipid Marker Levels and Reflect Accelerated Endothelial Dysfunction in Experimental Animals.
    Mediators of inflammation, 2018, Volume: 2018

    Topics: Animals; Arginine; Aryldialkylphosphatase; C-Reactive Protein; Cholesterol; Dyslipidemias; Homocysteine; Hypercholesterolemia; Inflammation; Interleukin-6; Lipids; Male; Oxysterols; Rabbits; Tumor Necrosis Factor-alpha

2018
Asymmetric dimethylarginine contributes to retinal neovascularization of diabetic retinopathy through EphrinB2 pathway.
    Vascular pharmacology, 2018, Volume: 108

    Topics: Amidohydrolases; Animals; Arginine; Cell Hypoxia; Cell Line; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelial Cells; Ephrin-B2; Human Umbilical Vein Endothelial Cells; Humans; Macaca mulatta; Male; Protein-Arginine N-Methyltransferases; Rats, Sprague-Dawley; Retinal Neovascularization; Retinal Vessels; RNA Interference; Signal Transduction

2018
Asymmetric and symmetric dimethylarginines and mortality in patients with hematological malignancies-A prospective study.
    PloS one, 2018, Volume: 13, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers, Tumor; Case-Control Studies; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; Middle Aged; Prognosis; Prospective Studies; Survival Rate; Young Adult

2018
Dimethylarginine dimethylaminohydrolase (DDAH) overexpression enhances wound repair in airway epithelial cells exposed to agricultural organic dust.
    Inhalation toxicology, 2018, Volume: 30, Issue:3

    Topics: Amidohydrolases; Animal Husbandry; Animals; Arginine; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dust; Epithelial Cells; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Protein Kinase C; Trachea; Wound Healing

2018
Asymmetrical Dimethylarginine Levels in Hepatitis B Virus-Positive Patients.
    Annals of laboratory medicine, 2018, Volume: 38, Issue:5

    Topics: Adult; Alanine Transaminase; alpha-Fetoproteins; Arginine; Aspartate Aminotransferases; Carrier State; Case-Control Studies; DNA, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged

2018
Correlation of Salusin Beta with hs-CRP and ADMA in Hypertensive Children and Adolescents.
    Current pharmaceutical design, 2018, Volume: 24, Issue:30

    Topics: Adolescent; Arginine; C-Reactive Protein; Child; Cohort Studies; Female; Humans; Hypertension; Intercellular Signaling Peptides and Proteins; Male; Prospective Studies

2018
Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis.
    Arthritis research & therapy, 2018, 06-08, Volume: 20, Issue:1

    Topics: Aged; Arginase; Arginine; Arthritis, Rheumatoid; Biomarkers; Cardiovascular Diseases; Comorbidity; Female; Humans; Hyperlipidemias; Hypertension; Male; Middle Aged; Prevalence; Risk Factors; United States

2018
Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs.
    Circulation, 2018, 11-20, Volume: 138, Issue:21

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Blood Pressure; Blood Urea Nitrogen; Cardiovascular Diseases; Celecoxib; Creatinine; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Kidney; Metabolome; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteoarthritis; Placebo Effect

2018
Role of plasma asymmetric dimethyl-L-arginine levels in detection of pulmonary hypertension in children with CHD.
    Cardiology in the young, 2018, Volume: 28, Issue:9

    Topics: Arginine; Biomarkers; Child, Preschool; Echocardiography; Female; Follow-Up Studies; Heart Defects, Congenital; Humans; Hypertension, Pulmonary; Infant; Infant, Newborn; Male; Nitric Oxide Synthase; Predictive Value of Tests; Prospective Studies; Pulmonary Wedge Pressure

2018
Evaluation of serum Asymmetric Dimethyl Arginine concentrations in coronary artery disease patients without traditional cardiovascular risk factors.
    Acta bio-medica : Atenei Parmensis, 2018, 06-07, Volume: 89, Issue:2

    Topics: Arginine; Biomarkers; Case-Control Studies; Coronary Artery Disease; Coronary Stenosis; Female; Humans; Male; Middle Aged

2018
Gender differences in the relationships between chronic kidney disease, asymmetric dimethylarginine, and sleep quality: The HEIJO-KYO cohort.
    Nitric oxide : biology and chemistry, 2018, 09-01, Volume: 79

    Topics: Aged; Arginine; Cohort Studies; Female; Humans; Male; Multivariate Analysis; Quality of Life; Renal Insufficiency, Chronic; Sex Characteristics; Sex Factors; Sleep Hygiene; Surveys and Questionnaires

2018
Proton pump inhibitors and Raynaud's phenomenon: is there a link?
    British journal of clinical pharmacology, 2018, Volume: 84, Issue:10

    Topics: Adverse Drug Reaction Reporting Systems; Amidohydrolases; Arginine; Gastroesophageal Reflux; Histamine H2 Antagonists; Humans; Pharmacovigilance; Proton Pump Inhibitors; Raynaud Disease

2018
FGF23 impairs peripheral microvascular function in renal failure.
    American journal of physiology. Heart and circulatory physiology, 2018, 11-01, Volume: 315, Issue:5

    Topics: Animals; Arginine; Cells, Cultured; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Endothelial Cells; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Gracilis Muscle; Humans; Kidney; Male; Mice, Inbred C57BL; Microcirculation; Microvessels; Renal Insufficiency, Chronic; Signal Transduction; Vascular Resistance; Vasodilation; Vasodilator Agents

2018
SZSJ protects against insomnia by a decrease in ADMA level and an improvement in DDAH production in sleep-deprived rats.
    Life sciences, 2018, Sep-15, Volume: 209

    Topics: Amidohydrolases; Animals; Arginine; Hypnotics and Sedatives; Male; Protective Agents; Rats; Rats, Sprague-Dawley; Sleep Deprivation; Sleep Initiation and Maintenance Disorders; Ziziphus

2018
Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018, 08-29, Volume: 38, Issue:35

    Topics: Aging; Amino Acid Sequence; Animals; Arginine; Cell Line; Cyclic AMP Response Element-Binding Protein; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; Isometric Contraction; Male; Mice; Mice, Knockout; Mice, Transgenic; Motor Neurons; Muscle Cells; Neuromuscular Junction; Protein-Arginine N-Methyltransferases; Recombinant Fusion Proteins; Reflex, Abnormal; RNA Interference; RNA, Small Interfering; Rotarod Performance Test; Spinal Cord

2018
Nephroprotective effects of nebivolol in 2K1C rats through regulation of the kidney ROS-ADMA-NO pathway.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:5

    Topics: Amidohydrolases; Angiotensin II; Animals; Arginine; Atenolol; Blood Pressure; Hypertension, Renovascular; Kidney; Kidney Function Tests; Male; NADPH Oxidases; Nebivolol; Nitric Oxide; Nitric Oxide Synthase; Protective Agents; Protein-Arginine N-Methyltransferases; Rats; Reactive Oxygen Species; Signal Transduction

2018
Plasma Homoarginine Concentrations According to Use of Hormonal Contraception.
    Scientific reports, 2018, 08-15, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Arginine; Chromatography, Liquid; Contraception; Contraceptives, Oral, Hormonal; Estrogens; Female; Homoarginine; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Progestins; Tandem Mass Spectrometry; Young Adult

2018
ADMA, homocysteine and redox status improvement affected by 7-nitroindazole in spontaneously hypertensive rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 106

    Topics: Animals; Aorta; Arginine; Biomarkers; Disease Models, Animal; Enzyme Inhibitors; Heart Ventricles; Homocysteine; Hypertension; Indazoles; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidation-Reduction; Rats, Inbred SHR

2018
Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial.
    Diabetes, obesity & metabolism, 2019, Volume: 21, Issue:2

    Topics: Aged; Aged, 80 and over; Arginine; Case-Control Studies; Citrulline; Cohort Studies; Diabetes Mellitus, Type 2; Diet, Fat-Restricted; Diet, Mediterranean; Female; Humans; Incidence; Insulin Resistance; Male; Middle Aged; omega-N-Methylarginine; Ornithine; Risk Factors

2019
Cerebrovascular reactivity and cerebral perfusion of rats with acute liver failure: role of L-glutamine and asymmetric dimethylarginine in L-arginine-induced response.
    Journal of neurochemistry, 2018, Volume: 147, Issue:5

    Topics: Animals; Arginine; Brain; Cerebrovascular Circulation; Extracellular Space; Glutamine; Liver Failure, Acute; Magnetic Resonance Imaging; Male; Middle Cerebral Artery; Muscle, Smooth, Vascular; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Thioacetamide

2018
Serum asymmetric dimethylarginine and nitric oxide levels in Turkish patients with acute ischemic stroke.
    Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 2019, Volume: 28, Issue:5

    Topics: Aged; Aged, 80 and over; Arginine; Brain Ischemia; Female; Humans; Male; Middle Aged; Nitric Oxide; Stroke

2019
Plethysmographic and biochemical markers in the diagnosis of endothelial dysfunction in pediatric acute lymphoblastic leukemia survivors - new applications.
    Physiological research, 2018, 12-18, Volume: 67, Issue:6

    Topics: Adolescent; Arginine; Biomarkers; C-Reactive Protein; Child; E-Selectin; Endothelium, Vascular; Female; Humans; Male; Plethysmography; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Risk Factors; Vascular Diseases

2018
Urinary sodium-to-potassium ratio and serum asymmetric dimethylarginine levels in patients with type 2 diabetes.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2018, Volume: 41, Issue:11

    Topics: Adult; Aged, 80 and over; Arginine; Blood Pressure; Carotid Intima-Media Thickness; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Obesity; Potassium; Sodium

2018
Usefulness of Asymmetric Dimethylarginine to Predict Outcomes After Heart Transplantation.
    The American journal of cardiology, 2018, 11-15, Volume: 122, Issue:10

    Topics: Adult; Allografts; Arginine; Biomarkers; California; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Heart Transplantation; Humans; Incidence; Male; Middle Aged; Nitric Oxide Synthase; Postoperative Period; Primary Graft Dysfunction; Prognosis; Retrospective Studies; Risk Assessment; Risk Factors; Survival Rate; Time Factors

2018
Development of a novel UHPLC-MS/MS-based platform to quantify amines, amino acids and methylarginines for applications in human disease phenotyping.
    Scientific reports, 2018, 09-18, Volume: 8, Issue:1

    Topics: Aged; Amines; Amino Acids; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Female; Humans; Male; Prognosis; Systemic Inflammatory Response Syndrome; Tandem Mass Spectrometry

2018
Homoarginine/ADMA ratio and homoarginine/SDMA ratio as independent predictors of cardiovascular mortality and cardiovascular events in lower extremity arterial disease.
    Scientific reports, 2018, 09-21, Volume: 8, Issue:1

    Topics: Aged; Arginine; Biomarkers; Cardiovascular Diseases; Cardiovascular System; Female; Homoarginine; Humans; Incidence; Lower Extremity; Male; Middle Aged; Prospective Studies; Risk Factors; Vascular Diseases

2018
Association of Uremic Toxins and Inflammatory Markers with Physical Performance in Dialysis Patients.
    Toxins, 2018, 10-01, Volume: 10, Issue:10

    Topics: Adult; Aged; Arginine; beta 2-Microglobulin; Biomarkers; C-Reactive Protein; Female; Hand Strength; Humans; Indican; Inflammation; Insulin-Like Growth Factor I; Interleukin-6; Male; Middle Aged; Myostatin; Physical Functional Performance; Renal Dialysis; Toxins, Biological; Urea; Uremia; Walking

2018
AGXT2 and DDAH-1 genetic variants are highly correlated with serum ADMA and SDMA levels and with incidence of coronary artery disease in Egyptians.
    Molecular biology reports, 2018, Volume: 45, Issue:6

    Topics: Adult; Amidohydrolases; Arginine; Case-Control Studies; Coronary Artery Disease; Egypt; Female; Genetic Variation; Genotype; Humans; Incidence; Male; Middle Aged; Nitric Oxide; Polymorphism, Single Nucleotide; Transaminases

2018
Role of microcirculatory function and plasma biomarkers in determining the development of cardiovascular adverse events in patients with peripheral arterial disease: A 5-year follow-up.
    Anatolian journal of cardiology, 2018, Volume: 20, Issue:4

    Topics: Arginine; Biomarkers; Blood Flow Velocity; C-Reactive Protein; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Male; Microcirculation; Middle Aged; Peripheral Arterial Disease; Predictive Value of Tests; Prospective Studies; Risk Factors; Turkey

2018
Utility of homoarginine in the GC-MS quantification of asymmetric dimethylarginine (ADMA) in human serum proteins.
    Analytical biochemistry, 2018, 12-15, Volume: 563

    Topics: Aged; Amino Acids; Arginine; Blood Proteins; Female; Gas Chromatography-Mass Spectrometry; Homoarginine; Humans; Male

2018
Hemodynamic, Autonomic, and Vascular Function Changes after Sleep Deprivation for 24, 28, and 32 Hours in Healthy Men.
    Yonsei medical journal, 2018, Volume: 59, Issue:9

    Topics: Adult; Arginine; Autonomic Nervous System; Baroreflex; Blood Pressure; Female; Healthy Volunteers; Heart; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Nitric Oxide Synthase Type III; Sleep Deprivation; Young Adult

2018
ADMA and NT pro-BNP are associated with overall mortality in elderly.
    European journal of clinical investigation, 2019, Volume: 49, Issue:1

    Topics: Age Distribution; Aged; Aged, 80 and over; Arginine; Austria; Biomarkers; Body Mass Index; Cardiovascular Diseases; Female; Health Services for the Aged; Hospitalization; Humans; Male; Natriuretic Peptide, Brain; Peptide Fragments; Prospective Studies; Risk Factors; Sex Distribution; Survival Analysis

2019
Serum ADMA, endothelial dysfunction, and atherosclerosis in hypervolemic \ hemodialysis patients
    Turkish journal of medical sciences, 2018, Oct-31, Volume: 48, Issue:5

    Topics: Arginine; Atherosclerosis; C-Reactive Protein; Carotid Intima-Media Thickness; Cohort Studies; Echocardiography; Female; Humans; Male; Middle Aged; Renal Dialysis

2018
Arginine bioavailability and endothelin-1 system in the regulation of vascular function of umbilical vein endothelial cells from intrauterine growth restricted newborns.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2018, Volume: 28, Issue:12

    Topics: Adult; Amidohydrolases; Arginase; Arginine; Case-Control Studies; Cell Proliferation; Cells, Cultured; Endothelin-1; Female; Fetal Growth Retardation; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Infant, Newborn; Male; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Pregnancy; Protein-Arginine N-Methyltransferases; Receptor, Endothelin B; Repressor Proteins; Signal Transduction; Umbilical Veins

2018
Probucol improves erectile function via Activation of Nrf2 and coordinates the HO-1 / DDAH / PPAR-γ/ eNOS pathways in streptozotocin-induced diabetic rats.
    Biochemical and biophysical research communications, 2018, 12-09, Volume: 507, Issue:1-4

    Topics: Amidohydrolases; Animals; Arginine; Blood Glucose; Body Weight; Cyclic GMP; Diabetes Mellitus, Experimental; Erectile Dysfunction; Heme Oxygenase-1; Male; Malondialdehyde; NF-E2-Related Factor 2; Nitric Oxide Synthase Type III; PPAR gamma; Probucol; Rats, Sprague-Dawley; Signal Transduction; Streptozocin; Superoxide Dismutase

2018
Impact of arsenic exposure on clinical biomarkers indicative of cardiovascular disease risk in Mexican women.
    Ecotoxicology and environmental safety, 2019, Volume: 169

    Topics: Adult; Aged; Arginine; Arsenic; Biomarkers; Cardiovascular Diseases; Cross-Sectional Studies; Drinking Water; Environmental Exposure; Fatty Acid-Binding Proteins; Female; Humans; Male; Mexico; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Risk Factors; Surveys and Questionnaires; Water Pollutants, Chemical

2019
Protein-energy wasting and asymmetric dimethylarginine in peritoneal dialysis patients.
    Acta biochimica Polonica, 2018, Dec-03, Volume: 65, Issue:4

    Topics: Adiponectin; Adult; Aged; Arginine; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Energy Metabolism; Humans; Interleukin-6; Kidney Failure, Chronic; Leptin; Lipoproteins, LDL; Middle Aged; Peritoneal Dialysis; Risk Factors; Tumor Necrosis Factor-alpha

2018
Alterations in arginine and energy metabolism, structural and signalling lipids in metastatic breast cancer in mice detected in plasma by targeted metabolomics and lipidomics.
    Breast cancer research : BCR, 2018, 12-04, Volume: 20, Issue:1

    Topics: Animals; Arginase; Arginine; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Chromatography, High Pressure Liquid; Disease Models, Animal; Energy Metabolism; Female; Humans; Lipid Metabolism; Lipids; Metabolomics; Mice; Mice, Inbred BALB C; Neoplasm Staging; Polyamines; Tandem Mass Spectrometry

2018
Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity.
    Critical care (London, England), 2018, 12-11, Volume: 22, Issue:1

    Topics: Amidohydrolases; Arginine; Biomarkers; Humans; Organ Dysfunction Scores; Polymorphism, Single Nucleotide; Protective Agents; Shock, Septic; Statistics, Nonparametric; Time Factors

2018
Chronic intermittent hypoxia-mediated renal sympathetic nerve activation in hypertension and cardiovascular disease.
    Scientific reports, 2018, 12-18, Volume: 8, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Angiotensins; Animals; Arginine; Cardiovascular Diseases; Deoxyguanosine; Disease Models, Animal; Humans; Hypertension; Hypoxia; Kidney; Male; Mice; Mice, Inbred C57BL; Norepinephrine; Oxidative Stress; Sympathectomy; Sympathetic Nervous System

2018
Plasma asymmetric dimethylarginine concentrations are not related to differences in maximal oxygen uptake in endurance trained and untrained men.
    Experimental physiology, 2019, Volume: 104, Issue:2

    Topics: Adult; Arginine; Endurance Training; Exercise; Exercise Test; Humans; Male; Muscles; Nitric Oxide; Oxygen; Physical Endurance

2019
DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats.
    International journal of molecular medicine, 2019, Volume: 43, Issue:2

    Topics: Amidohydrolases; Animals; Arginine; Cell Line; Diabetic Cardiomyopathies; Fibrosis; Male; Matrix Metalloproteinase 2; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Rats; Signal Transduction; Tissue Inhibitor of Metalloproteinase-2

2019
The iridoid loganic acid and anthocyanins from the cornelian cherry (Cornus mas L.) fruit increase the plasma l-arginine/ADMA ratio and decrease levels of ADMA in rabbits fed a high-cholesterol diet.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, Volume: 52

    Topics: Amidohydrolases; Animals; Anthocyanins; Arginine; Atherosclerosis; Cholesterol, Dietary; Citrulline; Cornus; Dimethylamines; Fruit; Iridoids; Liver; Male; Nitric Oxide Synthase Type III; Rabbits

2019
Association of serum asymmetric dimethyl-arginine and troponin I levels as a risk of myocardial infarction in thalassemia.
    African health sciences, 2018, Volume: 18, Issue:3

    Topics: Arginine; Biomarkers; Case-Control Studies; Creatine Kinase, MB Form; Humans; L-Lactate Dehydrogenase; Myocardial Infarction; Risk Factors; Thalassemia; Troponin I

2018
Guanidino compound ratios are associated with stroke etiology, internal carotid artery stenosis and CHA
    Journal of the neurological sciences, 2019, 02-15, Volume: 397

    Topics: Aged; Arginine; Biomarkers; Brain Ischemia; Carotid Arteries; Carotid Stenosis; Cross-Sectional Studies; Female; Homoarginine; Humans; Intracranial Hemorrhages; Male; Middle Aged; Recurrence; Stroke

2019
Novel Cellularly Active Inhibitor Regresses DDAH1 Induced Prostate Tumor Growth by Restraining Tumor Angiogenesis through Targeting DDAH1/ADMA/NOS Pathway.
    ACS combinatorial science, 2019, 04-08, Volume: 21, Issue:4

    Topics: Amidohydrolases; Animals; Antineoplastic Agents; Arginine; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemokines; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice, Nude; Molecular Docking Simulation; Neovascularization, Pathologic; Nitric Oxide; Nitric Oxide Synthase Type II; Prostatic Neoplasms; Pyridines; Signal Transduction; Transcription Factors; Vascular Endothelial Growth Factor A

2019
Is Asymmetric Dimethylarginine a Useful Biomarker in Children With Carbon Monoxide Poisoning?
    Pediatric emergency care, 2019, Volume: 35, Issue:3

    Topics: Adolescent; Arginine; Biomarkers; Blood Gas Analysis; Carbon Monoxide Poisoning; Carboxyhemoglobin; Case-Control Studies; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lactic Acid; Male; Methemoglobin

2019
Increased asymmetric dimethylarginine in vitamin B12 deficient adolescents.
    Cardiology in the young, 2019, Volume: 29, Issue:2

    Topics: Adolescent; Arginine; Atherosclerosis; Biomarkers; Carotid Arteries; Carotid Intima-Media Thickness; Case-Control Studies; Child; Chromatography, High Pressure Liquid; Echocardiography; Female; Humans; Hyperhomocysteinemia; Male; Vascular Stiffness; Vitamin B 12 Deficiency

2019
Total methylated arginine load as a risk parameter in subjects with masked hypertension.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2020, Volume: 42, Issue:2

    Topics: Arginine; Biomarkers; Blood Pressure Determination; Female; Humans; Hypertension; Male; Masked Hypertension; Middle Aged; Nitric Oxide; omega-N-Methylarginine; Risk Factors

2020
Reduced asymmetric dimethylarginine accumulation through inhibition of the type I protein arginine methyltransferases promotes renal fibrosis in obstructed kidneys.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:6

    Topics: Animals; Arginine; Cell Line; Gene Expression Regulation, Enzymologic; Humans; Kidney Diseases; Male; Mice; Nitric Oxide; Protein-Arginine N-Methyltransferases; Specific Pathogen-Free Organisms; Ureteral Obstruction

2019
LC-QQQ-MS routine analysis method for new biomarker quantification in plasma aimed at early chronic kidney disease diagnosis.
    Journal of pharmaceutical and biomedical analysis, 2019, May-30, Volume: 169

    Topics: Arginine; Biomarkers; Child; Child, Preschool; Chromatography, Liquid; Citrulline; Creatinine; Early Diagnosis; Female; Glomerular Filtration Rate; Humans; Male; Metabolomics; Plasma; Renal Insufficiency, Chronic; S-Adenosylmethionine; Tandem Mass Spectrometry

2019
Procyanidin B2 from lotus seedpod regulate NO/ADMA/DDAH pathway to treat insomnia in rats.
    Fundamental & clinical pharmacology, 2019, Volume: 33, Issue:5

    Topics: Amidohydrolases; Animals; Arginine; Biflavonoids; Brain; Catechin; Lotus; Neurons; Nitric Oxide; Proanthocyanidins; Rats; Rats, Sprague-Dawley; Seeds; Signal Transduction; Sleep; Sleep Initiation and Maintenance Disorders

2019
The renal transport protein OATP4C1 mediates uptake of the uremic toxin asymmetric dimethylarginine (ADMA) and efflux of cardioprotective L-homoarginine.
    PloS one, 2019, Volume: 14, Issue:3

    Topics: Arginine; Cardiovascular Diseases; HEK293 Cells; Homoarginine; Humans; Inhibitory Concentration 50; Kidney; Kinetics; Organic Anion Transporters; Toxins, Biological

2019
Plasma ADMA, urinary ADMA excretion, and late mortality in renal transplant recipients.
    Amino acids, 2019, Volume: 51, Issue:6

    Topics: Adult; Arginine; Biomarkers; Cardiovascular Diseases; Creatinine; Female; Gas Chromatography-Mass Spectrometry; Humans; Kidney Transplantation; Male; Middle Aged; Netherlands; Tandem Mass Spectrometry; Transplant Recipients

2019
Negative Ion Mode Collision-Induced Dissociation for Analysis of Protein Arginine Methylation.
    Journal of the American Society for Mass Spectrometry, 2019, Volume: 30, Issue:7

    Topics: Amino Acid Sequence; Arginine; omega-N-Methylarginine; Peptides; Protein Processing, Post-Translational; Proteins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2019
Asymmetric dimethylarginine - a prognostic marker for transplant outcome?
    Haematologica, 2019, Volume: 104, Issue:4

    Topics: Arginine; Hematopoietic Stem Cell Transplantation; Prognosis; Stem Cell Transplantation

2019
Asymmetric dimethylarginine as a potential biomarker for management and follow-up of phenylketonuria.
    European journal of pediatrics, 2019, Volume: 178, Issue:6

    Topics: Arginine; Biomarkers; Case-Control Studies; Child; Creatinine; Cross-Sectional Studies; Diet, Protein-Restricted; Female; Humans; Male; Phenylketonurias; Spain

2019
Increased plasma concentration of 4-pyridone-3-carboxamide-1-ß-D-ribonucleoside (4PYR) in lung cancer. Preliminary studies.
    Nucleosides, nucleotides & nucleic acids, 2019, Volume: 38, Issue:10

    Topics: Aged; Arginine; Biomarkers, Tumor; Carcinoma, Squamous Cell; Endothelial Cells; Female; Humans; Lung Neoplasms; Male; Middle Aged; Niacinamide; Nucleosides; Pyridones; Tandem Mass Spectrometry

2019
Dronedarone induces regression of coronary artery remodeling related to better global antioxidant status.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2019, Volume: 42, Issue:10

    Topics: Animals; Antioxidants; Arginine; Coronary Vessels; Dronedarone; Male; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Remodeling; Vasoconstriction

2019
Decline of popliteal artery flow-mediated dilation with aging and possible involvement of asymmetric dimethylarginine in healthy men.
    Journal of medical ultrasonics (2001), 2019, Volume: 46, Issue:4

    Topics: Adult; Age Factors; Aging; Arginine; Brachial Artery; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Popliteal Artery; Reference Values; Sex Factors; Vasodilation

2019
Synthesis of docosahexaenoic acid-loaded silver nanoparticles for improving endothelial dysfunctions in experimental diabetes.
    Human & experimental toxicology, 2019, Volume: 38, Issue:8

    Topics: Animals; Arginine; Aryldialkylphosphatase; Blood Glucose; Diabetes Mellitus, Experimental; DNA Damage; Docosahexaenoic Acids; Insulin; Male; Membrane Lipids; Metal Nanoparticles; Nitric Oxide; Rats, Wistar; Silver

2019
Asymmetric dimethylation and citrullination of proteinic arginine and homoarginine synthesis in human Helicobacter pylori infection.
    Amino acids, 2019, Volume: 51, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Citrullination; Citrulline; Female; Gas Chromatography-Mass Spectrometry; Helicobacter Infections; Helicobacter pylori; Homoarginine; Humans; Lysine; Male; Methylation; Middle Aged; Nitric Oxide; Ornithine

2019
Distinct associations between plasma osteoprotegerin, homoarginine and asymmetric dimethylarginine in chronic kidney disease male patients with coronary artery disease.
    Amino acids, 2019, Volume: 51, Issue:6

    Topics: Aged; Arginine; Biomarkers; Coronary Artery Disease; Homoarginine; Humans; Male; Middle Aged; Osteoprotegerin; Renal Insufficiency, Chronic

2019
Asymmetric Dimethylarginine Predicts One-year Recurrent Cardiovascular Events: Potential Biomarker of "Toxin Syndrome" in Coronary Heart Disease.
    Chinese journal of integrative medicine, 2019, Volume: 25, Issue:5

    Topics: Arginine; Biomarkers; Coronary Disease; Humans; Odds Ratio; Recurrence; Risk Factors; ROC Curve; Syndrome

2019
Association between asymmetric dimethylarginine and in-stent restenosis tissue characteristics assessed by optical coherence tomography.
    International journal of cardiology, 2019, 08-15, Volume: 289

    Topics: Aged; Arginine; Biomarkers; Coronary Angiography; Coronary Restenosis; Coronary Vessels; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Plaque, Atherosclerotic; Prospective Studies; Prosthesis Failure; Risk Factors; Time Factors; Tomography, Optical Coherence

2019
The protective effects of polysaccharide extract from Xin-Ji-Er-Kang formula on Ang II-induced HUVECs injury, L-NAME-induced hypertension and cardiovascular remodeling in mice.
    BMC complementary and alternative medicine, 2019, Jun-13, Volume: 19, Issue:1

    Topics: Angiotensin II; Animals; Aorta; Arginine; Blood Pressure; Cytokines; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Endothelial Cells; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Hypertension; Inflammation; Male; Malondialdehyde; Mice; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phytotherapy; Superoxide Dismutase; Vascular Remodeling

2019
Asymmetric and Symmetric Protein Arginine Dimethylation: Concept and Postprandial Effects of High-Fat Protein Meals in Healthy Overweight Men.
    Nutrients, 2019, Jun-27, Volume: 11, Issue:7

    Topics: Adult; Arginine; Biomarkers; Diet, High-Fat; Diet, High-Protein; Gas Chromatography-Mass Spectrometry; Humans; Interleukin-6; Male; Middle Aged; Overweight; Postprandial Period; Time Factors; Tumor Necrosis Factor-alpha; Urinalysis; Young Adult

2019
The ameliorative effect of angiotensin 1-7 on experimentally induced-preeclampsia in rats: Targeting the role of peroxisome proliferator-activated receptors gamma expression & asymmetric dimethylarginine.
    Archives of biochemistry and biophysics, 2019, 08-15, Volume: 671

    Topics: Angiotensin I; Animals; Arginine; Blood Pressure; Female; Oxidative Stress; Peptide Fragments; Placenta; PPAR gamma; Pre-Eclampsia; Pregnancy; Proteinuria; Rats, Wistar; Sodium

2019
Establishment of reference values for the lysine acetylation marker N
    Amino acids, 2019, Volume: 51, Issue:9

    Topics: Adolescent; Adult; Arginine; Biomarkers; Cardiovascular Diseases; Carnitine; Chromatography, Liquid; Citrulline; Creatinine; Female; Homoarginine; Humans; Lysine; Male; Middle Aged; Ornithine; Reference Values; Renal Insufficiency, Chronic; Tandem Mass Spectrometry; Young Adult

2019
Metabolites of the Nitric Oxide (NO) Pathway Are Altered and Indicative of Reduced NO and Arginine Bioavailability in Patients with Cardiometabolic Diseases Complicated with Chronic Wounds of Lower Extremities: Targeted Metabolomics Approach (LC-MS/MS).
    Oxidative medicine and cellular longevity, 2019, Volume: 2019

    Topics: Aged; Arginine; Cardiovascular Diseases; Case-Control Studies; Chemokines; Citrulline; Cytokines; Female; Growth Hormone; Humans; Lower Extremity; Male; Metabolomics; Middle Aged; Nitric Oxide; Wounds and Injuries

2019
Asymmetric dimethylarginine predicts impaired epicardial coronary vasomotion in patients with angina in the absence of obstructive coronary artery disease.
    International journal of cardiology, 2020, 01-15, Volume: 299

    Topics: Angina Pectoris; Arginine; Biomarkers; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Female; Humans; Male; Middle Aged; Retrospective Studies; Risk Factors; Vasomotor System

2020
Intradialytic hypotension: beyond hemodynamics.
    Physiological research, 2019, 10-25, Volume: 68, Issue:5

    Topics: Aged; Aged, 80 and over; Aldosterone; Angiotensin-Converting Enzyme 2; Arginine; Biomarkers; Blood Pressure; Endothelin-1; Endothelium, Vascular; Female; Humans; Hypotension; Kidney Diseases; Male; Membrane Glycoproteins; Middle Aged; Peptidyl-Dipeptidase A; Renal Dialysis; Renin; Time Factors; Vascular Endothelial Growth Factor C

2019
The detrimental effect of asymmetric dimethylarginine on cholesterol efflux of macrophage foam cells: Role of the NOX/ROS signaling.
    Free radical biology & medicine, 2019, 11-01, Volume: 143

    Topics: Amidohydrolases; Animals; Arginine; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; Cholesterol; Cytokines; Enzyme Inhibitors; Foam Cells; Hyperlipidemias; Lipoproteins, LDL; Macrophages; Male; Mice; Mice, Knockout, ApoE; NADPH Oxidase 1; Reactive Oxygen Species; Triglycerides

2019
Interleukin enhancement binding factor 3 inhibits cardiac hypertrophy by targeting asymmetric dimethylarginine-nitric oxide.
    Nitric oxide : biology and chemistry, 2019, 12-01, Volume: 93

    Topics: Amidohydrolases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arginine; Cardiomegaly; Down-Regulation; Gene Knockdown Techniques; Losartan; Male; Myocytes, Cardiac; Nitric Oxide; Nuclear Factor 90 Proteins; Rats, Sprague-Dawley

2019
Young rats with increased circulatory asymmetric dimethylarginine exhibited spatial deficit and alterations in dorsal hippocampus brain-derived neurotrophic factor and asymmetric dimethylarginine: Effects of melatonin.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2019, Volume: 78

    Topics: Animals; Arginine; Brain-Derived Neurotrophic Factor; Hippocampus; Male; Melatonin; Rats; Rats, Sprague-Dawley; Spatial Behavior

2019
Targeted metabolomic analysis of nitric oxide/L-arginine pathway metabolites in dementia: association with pathology, severity, and structural brain changes.
    Scientific reports, 2019, 09-24, Volume: 9, Issue:1

    Topics: Arginine; Biomarkers; Brain; Citrulline; Dementia; Female; Humans; Male; Metabolomics; Middle Aged; Nitric Oxide; Signal Transduction

2019
Asymmetric dimethylarginine aggravates blood-retinal barrier breakdown of diabetic retinopathy via inhibition of intercellular communication in retinal pericytes.
    Amino acids, 2019, Volume: 51, Issue:10-12

    Topics: Animals; Apoptosis; Arginine; Blood-Retinal Barrier; Cell Communication; Cell Membrane Permeability; Cells, Cultured; Connexin 43; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Gap Junctions; Glucose; Male; Pericytes; Rats; Rats, Sprague-Dawley; Streptozocin

2019
Melatonin rescued methotrexate-induced spatial deficit and hyperhomocysteinemia and increased asymmetric dimethylarginine in plasma and dorsal hippocampus in developing rats.
    Life sciences, 2020, Feb-01, Volume: 242

    Topics: Animals; Animals, Newborn; Antimetabolites, Antineoplastic; Arginine; Disease Models, Animal; Hippocampus; Hyperhomocysteinemia; Male; Maze Learning; Melatonin; Methotrexate; Rats; Rats, Sprague-Dawley; Spatial Behavior

2020
Assessment of Endothelial Dysfunction with Methylated Arginines and L-arginine in Cadmium-Exposed People: a Pilot Study.
    Clinical laboratory, 2019, Oct-01, Volume: 65, Issue:10

    Topics: Adult; Arginine; Atherosclerosis; Cadmium; Chromatography, Liquid; Endothelium, Vascular; Environmental Pollutants; Humans; Hypertension; Male; Middle Aged; Occupational Exposure; Pilot Projects; Tandem Mass Spectrometry

2019
Dimethylarginine Dimethylaminohydrolase 1 Polymorphisms and Venous Intimal Hyperplasia in Hemodialysis Patients.
    American journal of nephrology, 2019, Volume: 50, Issue:6

    Topics: Aged; Aged, 80 and over; Amidohydrolases; Arginine; Arteriovenous Shunt, Surgical; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Hyperplasia; Kidney Failure, Chronic; Male; Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies; Renal Dialysis; Tunica Intima; Veins

2019
Changes in Water Soluble Uremic Toxins and Urinary Acute Kidney Injury Biomarkers After 10- and 100-km Runs.
    International journal of environmental research and public health, 2019, 10-28, Volume: 16, Issue:21

    Topics: Acute Kidney Injury; Acute-Phase Proteins; Adult; Albuminuria; Arginine; Biomarkers; Creatinine; Female; Glomerular Filtration Rate; Humans; Lipocalin-2; Lipocalins; Male; Methylamines; Middle Aged; Running; Urea; Uric Acid; Water

2019
Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis.
    Cardiovascular research, 2020, 10-01, Volume: 116, Issue:12

    Topics: Animals; Aorta; Arginine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 Enzyme System; Female; Intramolecular Oxidoreductases; Kidney; Male; Mice, Knockout; PPAR-beta; Prostaglandin-E Synthases; Prostaglandins I; Receptors, Cytoplasmic and Nuclear; Receptors, Epoprostenol; Receptors, Prostaglandin E

2020
Cell-Free Hemoglobin Is Associated With Increased Vascular Resistance and Reduced Peripheral Perfusion in Severe Malaria.
    The Journal of infectious diseases, 2020, 01-01, Volume: 221, Issue:1

    Topics: Adult; Arginine; Arterial Pressure; Bacteremia; Case-Control Studies; Echocardiography; Female; Hematocrit; Hemoglobins; Humans; Malaria, Falciparum; Male; Middle Aged; Nitric Oxide; Patient Acuity; Regional Blood Flow; Vascular Resistance; Young Adult

2020
Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice.
    Molecular medicine reports, 2020, Volume: 21, Issue:1

    Topics: Amidohydrolases; Animals; Anthocyanins; Aortic Valve Stenosis; Apoptosis; Arginine; Blueberry Plants; Cardiovascular Diseases; Disease Models, Animal; Gene Expression Regulation; Humans; Mice; Myocytes, Cardiac; Nitric Oxide; Oxidative Stress; Plant Extracts; Signal Transduction

2020
Impact of zinc oxide nanoparticles on thioredoxin-interacting protein and asymmetric dimethylarginine as biochemical indicators of cardiovascular disorders in gamma-irradiated rats.
    Environmental toxicology, 2020, Volume: 35, Issue:4

    Topics: Animals; Arginine; Biomarkers; Cardiotoxicity; Cell Cycle Proteins; Cytokines; Dose-Response Relationship, Drug; Gamma Rays; Heart; Inflammation; Male; Nanoparticles; Oxidative Stress; Radiation Injuries, Experimental; Rats; Zinc Oxide

2020
DDAH-2 alleviates contrast medium iopromide-induced acute kidney injury through nitric oxide synthase.
    Clinical science (London, England : 1979), 2019, 12-12, Volume: 133, Issue:23

    Topics: Acute Kidney Injury; Amidohydrolases; Animals; Arginine; Cell Line; Contrast Media; Female; Humans; Iohexol; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase; Rats; Reperfusion Injury

2019
Iron Overload Damages the Endothelial Mitochondria
    Oxidative medicine and cellular longevity, 2019, Volume: 2019

    Topics: Amidohydrolases; Animals; Arginine; Human Umbilical Vein Endothelial Cells; Humans; Iron Overload; Mice; Mitochondria; Nitric Oxide; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Signal Transduction

2019
ADMA elevation does not exacerbate development of diabetic nephropathy in mice with streptozotocin-induced diabetes mellitus.
    Atherosclerosis. Supplements, 2019, Volume: 40

    Topics: Amidohydrolases; Animals; Arginine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glomerular Filtration Rate; Male; Mice; Mice, Inbred C57BL; Risk Factors; Streptozocin

2019
Comparison of asymmetric dimethylarginine levels between pre- and post-menopausal women - a cross-sectional study from Rawalpindi.
    JPMA. The Journal of the Pakistan Medical Association, 2019, Volume: 69, Issue:12

    Topics: Adult; Arginine; Cross-Sectional Studies; Female; Humans; Middle Aged; Pakistan; Postmenopause; Premenopause

2019
Restoration of Adiponectin-Connexin43 Signaling Mitigates Myocardial Inflammation and Dysfunction in Diabetic Female Rats.
    Journal of cardiovascular pharmacology, 2020, Volume: 75, Issue:3

    Topics: Adiponectin; Animals; Arginine; Connexin 43; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Estradiol; Estrogen Receptor alpha; Female; Heme Oxygenase (Decyclizing); Hypertrophy, Left Ventricular; Ovariectomy; Piperidines; Rats, Wistar; Receptors, Adiponectin; Receptors, G-Protein-Coupled; Signal Transduction; Tumor Necrosis Factor-alpha; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling

2020
Quercetin protects the vascular endothelium against iron overload damages via ROS/ADMA/DDAHⅡ/eNOS/NO pathway.
    European journal of pharmacology, 2020, Feb-05, Volume: 868

    Topics: Amidohydrolases; Antioxidants; Apoptosis; Arginine; Cell Line; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Iron Overload; Mitochondria; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Quercetin; Reactive Oxygen Species; Signal Transduction

2020
Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy.
    American journal of physiology. Renal physiology, 2020, 02-01, Volume: 318, Issue:2

    Topics: Adenoviridae; Albuminuria; Amidohydrolases; Animals; Arginine; Cytokines; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibrosis; Genetic Therapy; Genetic Vectors; Inflammation Mediators; Kidney; Male; Mice, Inbred DBA; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Signal Transduction; Thiobarbituric Acid Reactive Substances

2020
Homocysteine and Asymmetrical Dimethylarginine in Diabetic Rats Treated with Docosahexaenoic Acid-Loaded Zinc Oxide Nanoparticles.
    Applied biochemistry and biotechnology, 2020, Volume: 191, Issue:3

    Topics: Animals; Arginine; Cellulose; Diabetes Mellitus, Experimental; Docosahexaenoic Acids; Homocysteine; Hyperhomocysteinemia; Insulin; Insulin Resistance; Male; Metal Nanoparticles; Microscopy, Electron, Transmission; Nitric Oxide; Rats; Risk Factors; Zinc Oxide

2020
Cardiovascular risk factors and the concentration of asymmetric dimethylarginine.
    Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 2020, Volume: 29, Issue:1

    Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Middle Aged; Risk Factors

2020
The Role of Reactive Oxygen Species and Nitric Oxide in the Inhibition of
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Arginine; Catecholamines; Cell Line; Enzyme Inhibitors; Humans; Imidazolines; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Peptide Hydrolases; Reactive Oxygen Species; Trichophyton

2020
Maternal serum levels of asymmetric dimethylarginine in normal and preeclamptic pregnancies.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2020, Volume: 36, Issue:8

    Topics: Adult; Arginine; Case-Control Studies; Cross-Sectional Studies; Female; Fetal Growth Retardation; Humans; Maternal Serum Screening Tests; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Third; Young Adult

2020
Tetramethylpyrazine alleviates iron overload damage in vascular endothelium via upregulating DDAHII expression.
    Toxicology in vitro : an international journal published in association with BIBRA, 2020, Volume: 65

    Topics: Amidohydrolases; Apoptosis; Arginine; Cell Survival; Cells, Cultured; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Iron Overload; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Pyrazines; Reactive Oxygen Species

2020
Dimethylarginine dimethylaminohydrolase-1 contributes to exercise-induced cardiac angiogenesis in mice.
    Bioscience trends, 2020, May-21, Volume: 14, Issue:2

    Topics: Amidohydrolases; Animals; Arginine; Behavior, Animal; Coronary Vessels; Glycogen Synthase Kinase 3 beta; Heart; Male; Mice; Mice, Knockout; Models, Animal; Neovascularization, Physiologic; Nitric Oxide; Physical Conditioning, Animal; Proto-Oncogene Proteins c-akt; ras Proteins; Sedentary Behavior; Signal Transduction

2020
Asymmetric dimethylarginine exacerbates cognitive dysfunction associated with cerebrovascular pathology.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020, Volume: 34, Issue:5

    Topics: Amyloid beta-Protein Precursor; Animals; Arginine; Cerebrovascular Disorders; Cognitive Dysfunction; Endothelium, Vascular; Enzyme Inhibitors; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic

2020
Serum Apelin and Asymmetric Dimethylarginine Levels in Patients With Exfoliation Syndrome or Exfoliative Glaucoma.
    Journal of glaucoma, 2020, Volume: 29, Issue:7

    Topics: Aged; Aged, 80 and over; Apelin; Arginine; Cross-Sectional Studies; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Exfoliation Syndrome; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmoscopy; Prospective Studies; Slit Lamp Microscopy; Tonometry, Ocular

2020
Dihydromyricetin increases endothelial nitric oxide production and inhibits atherosclerosis through microRNA-21 in apolipoprotein E-deficient mice.
    Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:10

    Topics: Amidohydrolases; Animals; Apolipoproteins E; Arginine; Atherosclerosis; Enzyme Activation; Flavonols; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipid Metabolism; Lipids; Liver; Male; Mice, Inbred C57BL; MicroRNAs; Nitric Oxide; Nitric Oxide Synthase Type III; Signal Transduction

2020
Evaluation of asymmetric dimethylarginine as an inflammatory and prognostic marker in dogs with acute pancreatitis.
    Journal of veterinary internal medicine, 2020, Volume: 34, Issue:3

    Topics: Animals; Arginine; Biomarkers; C-Reactive Protein; Cohort Studies; Dog Diseases; Dogs; Female; Lipase; Male; Pancreatitis; Prognosis; Systemic Inflammatory Response Syndrome

2020
Asymmetric dimethylarginine and angiopoietin-like protein-2 are independent predictors of cardiovascular risk in pre-dialysis non-diabetic chronic kidney disease patients.
    International urology and nephrology, 2020, Volume: 52, Issue:7

    Topics: Adolescent; Adult; Angiopoietin-Like Protein 2; Angiopoietin-like Proteins; Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Predictive Value of Tests; Renal Insufficiency, Chronic; Risk Assessment; Young Adult

2020
Circulating asymmetric dimethylarginine and cognitive decline: A 4-year follow-up study of the 1936 Aberdeen Birth Cohort.
    International journal of geriatric psychiatry, 2020, Volume: 35, Issue:10

    Topics: Arginine; Cognitive Dysfunction; Follow-Up Studies; Humans; Nitric Oxide Synthase

2020
Arginine derivatives in atrial fibrillation progression phenotypes.
    Journal of molecular medicine (Berlin, Germany), 2020, Volume: 98, Issue:7

    Topics: Aged; Arginine; Atrial Fibrillation; Biomarkers; Cohort Studies; Disease Progression; Female; Homoarginine; Humans; Male; Middle Aged; Phenotype

2020
Elevated plasma levels of asymmetric dimethylarginine and the risk for arrhythmic death in ischemic and non-ischemic, dilated cardiomyopathy - A prospective, controlled long-term study.
    Clinical biochemistry, 2020, Volume: 83

    Topics: Aged; Arginine; Arrhythmias, Cardiac; Cardiomyopathy, Dilated; Case-Control Studies; Female; Heart Arrest; Humans; Male; Middle Aged; Myocardial Ischemia; Prospective Studies; Risk Factors; Ventricular Dysfunction, Left

2020
Influence of Human Paraoxonase-1 Polymorphism (Q192R) on Serum Levels of Clinical Biomarkers Indicatives of Cardiovascular Diseases Risk in Mexican Women.
    Biochemical genetics, 2020, Volume: 58, Issue:5

    Topics: Adult; Arginine; Aryldialkylphosphatase; Biomarkers; Cardiovascular Diseases; Cross-Sectional Studies; Fatty Acid-Binding Proteins; Female; Genetic Predisposition to Disease; Heart Disease Risk Factors; Humans; Male; Mexico; MicroRNAs; Polymorphism, Genetic; Sex Factors

2020
Increased symmetric dimethylarginine, but not asymmetric dimethylarginine, concentrations are associated with transient myocardial ischemia and predict outcome.
    The Journal of international medical research, 2020, Volume: 48, Issue:6

    Topics: Aged; Arginine; Biomarkers; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Dipyridamole; Female; Follow-Up Studies; Heart; Heart Function Tests; Humans; Male; Middle Aged; Myocardial Perfusion Imaging; Prospective Studies; Risk Assessment; Tomography, X-Ray Computed

2020
Asymmetric dimethylarginine and L-homoarginine prospectively relate to carotid wall thickness in a South African cohort.
    Amino acids, 2020, Volume: 52, Issue:6-7

    Topics: Aged; Arginine; Black People; Blood Pressure; Carotid Intima-Media Thickness; Cohort Studies; Female; Homoarginine; Humans; Male; Middle Aged; Nitric Oxide; Prospective Studies; Ultrasonography

2020
Comprehensive arginine metabolomics and peripheral vasodilatory capacity in rheumatoid arthritis: A monocentric cross-sectional study.
    Microvascular research, 2020, Volume: 131

    Topics: Aged; Aged, 80 and over; Arginine; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Citrulline; Cross-Sectional Studies; Female; Fingers; Homoarginine; Humans; Italy; Male; Metabolomics; Middle Aged; Vasodilation

2020
Assessment of ADMA, IMA, and Vitamin A and E Levels in Patients with Acne Vulgaris.
    Journal of cosmetic dermatology, 2020, Volume: 19, Issue:12

    Topics: Acne Vulgaris; Adolescent; Adult; Arginine; Biomarkers; Humans; Serum Albumin; Serum Albumin, Human; Vitamin A

2020
Vectorial transport of the arginine derivatives asymmetric dimethylarginine (ADMA) and L-homoarginine by OATP4C1 and P-glycoprotein studied in double-transfected MDCK cells.
    Amino acids, 2020, Volume: 52, Issue:6-7

    Topics: Animals; Arginine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dogs; Homoarginine; Humans; Madin Darby Canine Kidney Cells; Organic Anion Transporters; Transcytosis; Transfection

2020
Evaluation of Plasma Asymmetric Dimethylarginine Levels and Abdominal Aortic Intima-Media Thickness in Infants of Smoker Mothers.
    American journal of perinatology, 2021, Volume: 38, Issue:14

    Topics: Adult; Aorta, Abdominal; Arginine; Case-Control Studies; Cigarette Smoking; Echocardiography; Female; Humans; Infant, Newborn; Male; Maternal Exposure; Mothers; Pregnancy; Prospective Studies; Smokers; Tunica Intima

2021
Asymmetric dimethylarginine compartmental behavior during high-flux hemodialysis.
    Renal failure, 2020, Volume: 42, Issue:1

    Topics: Adult; Arginine; Cardiovascular Diseases; Creatinine; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Tandem Mass Spectrometry; Urea

2020
Effect of high-altitude trekking on blood pressure and on asymmetric dimethylarginine and isoprostane production: Results from a Mount Ararat expedition.
    Journal of clinical hypertension (Greenwich, Conn.), 2020, Volume: 22, Issue:8

    Topics: Altitude; Arginine; Blood Pressure; Expeditions; Humans; Hypertension; Hypoxia; Isoprostanes; Male; Turkey

2020
Renal asymmetric dimethylarginine inhibits fibrosis.
    FEBS open bio, 2020, Volume: 10, Issue:10

    Topics: Amidohydrolases; Animals; Arginine; Disease Models, Animal; Fibronectins; Fibrosis; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Renal Insufficiency, Chronic; Ureteral Obstruction

2020
The investigation of antioxidant and anti-inflammatory potentials of apitherapeutic agents on heart tissues in nitric oxide synthase inhibited rats via Nω-nitro-L-arginine methyl ester.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2021, Jan-02, Volume: 43, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arginine; Aryldialkylphosphatase; Blood Pressure; Caffeic Acids; Free Radical Scavengers; Male; Myocardium; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidants; Oxidative Stress; Phenylethyl Alcohol; Pollen; Propolis; Rats; Rats, Sprague-Dawley

2021
The effect of nitric oxide, endothelial nitric oxide synthetase, and asymmetric dimethylarginine in hemorrhoidal disease.
    Revista da Associacao Medica Brasileira (1992), 2020, Volume: 66, Issue:8

    Topics: Arginine; Hemorrhoids; Humans; Nitric Oxide; Nitric Oxide Synthase Type III

2020
[Asymmetric dimethylarginine (ADMA) in retinal vein occlusion-Results from the Gutenberg RVO study].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2021, Volume: 118, Issue:7

    Topics: Aged; Arginine; Humans; Hypertension; Retinal Vein Occlusion; Risk Factors

2021
ADMA (asymmetric dimethylarginine) and angiogenic potential in patients with type 2 diabetes and prediabetes.
    Experimental biology and medicine (Maywood, N.J.), 2021, Volume: 246, Issue:2

    Topics: Adult; Aged; Arginine; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Neovascularization, Physiologic; Prediabetic State; Solubility; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1

2021
Asymmetric dimethylarginine (ADMA) accelerates renal cell fibrosis under high glucose condition through NOX4/ROS/ERK signaling pathway.
    Scientific reports, 2020, 09-29, Volume: 10, Issue:1

    Topics: Animals; Arginine; Cell Line; Cell Movement; Cell Proliferation; Cells, Cultured; Diabetic Retinopathy; Fibroblasts; Fibrosis; Glucose; Kidney; MAP Kinase Signaling System; Mesangial Cells; Models, Biological; NADPH Oxidase 4; Rats; Reactive Oxygen Species

2020
Increased Intraplatelet ADMA Level May Promote Platelet Activation in Diabetes Mellitus.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Adenosine Diphosphate; Adult; Aged; Arginine; Blood Platelets; Calcium; Case-Control Studies; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Female; Humans; Male; Mass Spectrometry; Middle Aged; Nitric Oxide; Platelet Activation; Platelet Aggregation; Risk Factors

2020
Pharmacologic downregulation of protein arginine methyltransferase1 expression by adenosine dialdehyde increases cell senescence in breast cancer.
    European journal of pharmacology, 2021, Jan-15, Volume: 891

    Topics: Adenosine; Antineoplastic Combined Chemotherapy Protocols; Arginine; Betaine-Homocysteine S-Methyltransferase; Breast Neoplasms; Cell Cycle Checkpoints; Cell Proliferation; Cellular Senescence; Down-Regulation; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Methylation; Molecular Docking Simulation; Oxidative Stress; Phosphatidylethanolamine N-Methyltransferase; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Repressor Proteins; Signal Transduction; Tamoxifen

2021
Association of Asymmetric Dimethylarginine and Nitric Oxide with Cardiovascular Risk in Patients with End-Stage Liver Disease.
    Medicina (Kaunas, Lithuania), 2020, Nov-18, Volume: 56, Issue:11

    Topics: Adult; Arginine; Cardiovascular Diseases; End Stage Liver Disease; Heart Disease Risk Factors; Humans; Nitric Oxide; Risk Factors; Severity of Illness Index

2020
Serum asymmetric-dimethylarginine, apelin and NT-pro BNP levels in dialysis patients.
    Nigerian journal of clinical practice, 2020, Volume: 23, Issue:11

    Topics: Adult; Aged; Apelin; Arginine; Biomarkers; Blood Pressure; Blood Pressure Determination; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Peritoneal Dialysis; Renal Dialysis

2020
Asymmetric dimethylarginine-A potential cardiac biomarker in horses.
    Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology, 2021, Volume: 33

    Topics: Animals; Arginine; Biomarkers; Enzyme-Linked Immunosorbent Assay; Female; Heart Diseases; Horse Diseases; Horses; Male; Prospective Studies; Reference Values

2021
Evaluation of Biomarkers in Sepsis: High Dimethylarginine (ADMA and SDMA) Concentrations Are Associated with Mortality.
    The journal of applied laboratory medicine, 2021, 04-29, Volume: 6, Issue:3

    Topics: Arginine; Biomarkers; Humans; Sepsis

2021
The shifted balance of arginine metabolites in acute myocardial infarction patients and its clinical relevance.
    Scientific reports, 2021, 01-08, Volume: 11, Issue:1

    Topics: Arginine; Citrulline; Coronary Angiography; Female; Humans; Male; Middle Aged; Ornithine; Proline; ST Elevation Myocardial Infarction; Treatment Outcome

2021
The Effect and Mechanism of Asymmetric Dimethylarginine Regulating Trophoblastic Autophagy on Fetal Growth Restriction.
    Reproductive sciences (Thousand Oaks, Calif.), 2021, Volume: 28, Issue:7

    Topics: Adenine; Adult; Arginine; Autophagy; Beclin-1; Cell Line, Tumor; Female; Fetal Growth Retardation; Humans; Matrix Metalloproteinase 9; Microtubule-Associated Proteins; Placenta; Pregnancy; Trophoblasts

2021
Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting.
    The Journal of biological chemistry, 2020, 12-18, Volume: 295, Issue:51

    Topics: Animals; Arginine; Cachexia; Female; Heterografts; Humans; Male; Mice; Mice, Inbred C57BL; Mitochondria, Muscle; Muscle Proteins; Neoplasms; omega-N-Methylarginine

2020
Intrathecal and systemic alterations of L-arginine metabolism in patients after intracerebral hemorrhage.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021, Volume: 41, Issue:8

    Topics: Aged; Arginine; Case-Control Studies; Cerebral Hemorrhage; Chromatography, High Pressure Liquid; Citrulline; Female; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Risk Factors; Tandem Mass Spectrometry; Up-Regulation

2021
Lack of evidence of the correlation between plasma Asymmetrical Dimethylarginine correlation and IMT in type 2 diabetic patients with chronic vascular complication.
    Acta biochimica Polonica, 2021, Feb-05, Volume: 68, Issue:1

    Topics: Adult; Aged; Arginine; Atherosclerosis; Carotid Artery, Internal; Carotid Intima-Media Thickness; Case-Control Studies; Chronic Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; Male; Middle Aged; Risk Factors; Ultrasonography, Doppler, Color

2021
Is there a relation between serum methylarginine levels and infertility?
    Hormone molecular biology and clinical investigation, 2021, Jan-27, Volume: 42, Issue:3

    Topics: Adult; Arginine; Biomarkers; Disease Susceptibility; Humans; Infertility; Male; Oligospermia; ROC Curve; Semen Analysis; Sperm Count; Young Adult

2021
Serum ADMA levels were positively correlated with EDSS scores in patients with multiple sclerosis.
    Journal of neuroimmunology, 2021, 04-15, Volume: 353

    Topics: Adult; Arginine; Female; Humans; Male; Multiple Sclerosis, Relapsing-Remitting; Nitric Oxide; Severity of Illness Index

2021
Impact of combined elevations of homocysteine and asymmetric dimethylarginine on all-cause death - The Tanushimaru Study.
    Journal of cardiology, 2021, Volume: 78, Issue:2

    Topics: Arginine; Female; Homocysteine; Humans; Male; Middle Aged; Proportional Hazards Models; Regression Analysis

2021
Altered methylarginine levels after surgery in subjects with multinodular goiter.
    Hormone molecular biology and clinical investigation, 2021, Feb-22, Volume: 42, Issue:3

    Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Goiter, Nodular; Humans; Male; Middle Aged; omega-N-Methylarginine; Postoperative Period; Sensitivity and Specificity

2021
Relation of asymmetric dimethylarginine with pulmonary morbidities in neonatal respiratory distress syndrome.
    Journal of neonatal-perinatal medicine, 2021, Volume: 14, Issue:4

    Topics: Adolescent; Arginine; Humans; Infant, Newborn; Infant, Premature; Morbidity; Prospective Studies; Respiratory Distress Syndrome, Newborn

2021
Whole-body arginine dimethylation is associated with all-cause mortality in adult renal transplant recipients.
    Amino acids, 2021, Volume: 53, Issue:4

    Topics: Adult; Aged; Arginine; Biomarkers; Cardiovascular Diseases; Cause of Death; Female; Heart Disease Risk Factors; Humans; Kidney Transplantation; Male; Methylation; Middle Aged; Protein Processing, Post-Translational; Tissue Donors; Transplant Recipients

2021
Clinically inapparent right heart dysfunction is associated with reduced myofilament force development in coronary artery disease.
    BMC cardiovascular disorders, 2021, 03-05, Volume: 21, Issue:1

    Topics: Aged; Arginine; Asymptomatic Diseases; Biomarkers; C-Reactive Protein; Calcium; Coronary Artery Bypass; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Myocardial Contraction; Myofibrils; Serum Albumin, Human; Serum Amyloid P-Component; Treatment Outcome; Ventricular Dysfunction, Right; Ventricular Function, Right

2021
Profile of new vascular damage biomarkers in middle-aged men with arterial hypertension.
    Advances in medical sciences, 2021, Volume: 66, Issue:1

    Topics: Adult; Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Endothelium, Vascular; Follow-Up Studies; Humans; Hypertension; Male; Malondialdehyde; Middle Aged; Nitric Oxide; Prognosis

2021
Maternal resveratrol therapy protected adult rat offspring against hypertension programmed by combined exposures to asymmetric dimethylarginine and trimethylamine-N-oxide.
    The Journal of nutritional biochemistry, 2021, Volume: 93

    Topics: Animals; Antioxidants; Arginine; Female; Gastrointestinal Microbiome; Hypertension; Methylamines; Pregnancy; Prenatal Exposure Delayed Effects; Prenatal Nutritional Physiological Phenomena; Rats; Renin-Angiotensin System; Resveratrol

2021
Electrophoretic Determination of Symmetric and Asymmetric Dimethylarginine in Human Blood Plasma with Whole Capillary Sample Injection.
    International journal of molecular sciences, 2021, Mar-15, Volume: 22, Issue:6

    Topics: Acetonitriles; Anions; Arginine; Electric Conductivity; Electrophoresis, Capillary; Humans; Limit of Detection

2021
Asymmetric dimethylarginine in psychiatric disorders.
    Psychiatry research, 2021, Volume: 300

    Topics: Arginine; Bipolar Disorder; Female; Humans; Male; Psychotic Disorders; Schizophrenia

2021
Association Between the Asymmetric Dimethylarginine Levels and Glaucoma Severity: A Cross-Sectional Analysis of the LIGHT Study.
    Investigative ophthalmology & visual science, 2021, 04-01, Volume: 62, Issue:4

    Topics: Aged; Arginine; Biomarkers; Cross-Sectional Studies; Female; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Male; Severity of Illness Index

2021
Endogenous asymmetric dimethylarginine accumulation precipitates the cardiac and mitochondrial dysfunctions in type 1 diabetic rats.
    European journal of pharmacology, 2021, Jul-05, Volume: 902

    Topics: Acetylcysteine; Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Free Radical Scavengers; Glycosylation; Heart Diseases; Insulin Resistance; Male; Mitochondria; Myocardial Contraction; Myocytes, Cardiac; Nitric Oxide; Papillary Muscles; Rats, Sprague-Dawley; Signal Transduction; Streptozocin

2021
Elevated serum SDMA and ADMA at hospital admission predict in-hospital mortality of COVID-19 patients.
    Scientific reports, 2021, 05-10, Volume: 11, Issue:1

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Cohort Studies; COVID-19; Female; Hospital Mortality; Hospitalization; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Risk Factors; SARS-CoV-2

2021
Evaluation of serum neutrophil gelatinase-associated lipocalin (NGAL), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) levels, and their relations with disease type and activity in inflammatory bowel diseases
    Turkish journal of medical sciences, 2021, 10-21, Volume: 51, Issue:5

    Topics: Adult; Aged; Arginine; Biomarkers; Colitis, Ulcerative; Crohn Disease; Female; Humans; Inflammatory Bowel Diseases; Lipocalin-2; Male; Middle Aged

2021
Invited commentary for asymmetric dimethylarginine (ADMA): Is it a risk factor in the repair of aortic coarctation?
    Journal of cardiac surgery, 2021, Volume: 36, Issue:8

    Topics: Aortic Coarctation; Arginine; Endothelium, Vascular; Humans; Risk Factors

2021
Asymmetric dimethylarginine: Is it a risk facgtor in the repair of aortic coarctation?
    Journal of cardiac surgery, 2021, Volume: 36, Issue:8

    Topics: Adult; Aorta; Aortic Coarctation; Arginine; Humans; Infant, Newborn; Nitric Oxide Synthase

2021
Evaluation of Asymmetric Dimethylarginine Levels in Patients With Chronic Thromboembolic Pulmonary Hypertension Undergoing Pulmonary Endarterectomy.
    Heart, lung & circulation, 2022, Volume: 31, Issue:1

    Topics: Arginine; Chronic Disease; Endarterectomy; Humans; Hypertension, Pulmonary

2022
The role of adrenergic and muscarinic receptors in stress-induced cardiac injury.
    Pflugers Archiv : European journal of physiology, 2021, Volume: 473, Issue:10

    Topics: Animals; Arginine; Corticosterone; Female; Heart Injuries; Male; Natriuretic Peptide, Brain; Organ Size; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Muscarinic; Spleen; Stress, Physiological

2021
Determination of serum methylarginine levels by tandem mass spectrometric method in patients with ankylosing spondylitis.
    Amino acids, 2021, Volume: 53, Issue:9

    Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Female; Humans; Male; Spondylitis, Ankylosing; Tandem Mass Spectrometry

2021
Resveratrol prevented spatial deficits and rescued disarrayed hippocampus asymmetric dimethylarginine and brain-derived neurotrophic factor levels in young rats with increased circulating asymmetric dimethylarginine.
    Neuroreport, 2021, 09-08, Volume: 32, Issue:13

    Topics: Animals; Antioxidants; Arginine; Brain-Derived Neurotrophic Factor; Hippocampus; Male; Maze Learning; Rats; Rats, Sprague-Dawley; Resveratrol; Spatial Behavior

2021
The Serum Levels of Asymmetric Dimethylarginine, Vascular Endothelial Growth Factor, and Insulin-Like Growth Factor-1 in Preterms with Retinopathy of Prematurity.
    Fetal and pediatric pathology, 2022, Volume: 41, Issue:4

    Topics: Arginine; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Insulin-Like Growth Factor I; Retinopathy of Prematurity; Vascular Endothelial Growth Factor A

2022
Vascular and immunopathological role of Asymmetric Dimethylarginine (ADMA) in Experimental Autoimmune Encephalomyelitis.
    Immunology, 2021, Volume: 164, Issue:3

    Topics: Animals; Arginine; Blood-Brain Barrier; CD4-Positive T-Lymphocytes; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Mice; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Pertussis Toxin

2021
A Cross-Talk between the Erythrocyte L-Arginine/ADMA/Nitric Oxide Metabolic Pathway and the Endothelial Function in Subjects with Type 2 Diabetes Mellitus.
    Nutrients, 2021, Jul-04, Volume: 13, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Citrulline; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Endothelium, Vascular; Erythrocytes; Female; Humans; Male; Metabolic Networks and Pathways; Middle Aged; Nitric Oxide

2021
Serum L-arginine and endogenous methylarginine concentrations predict irritable bowel syndrome in adults: A nested case-control study.
    United European gastroenterology journal, 2021, Volume: 9, Issue:7

    Topics: Aged; Aged, 80 and over; Arginine; Biomarkers; Case-Control Studies; Cohort Studies; Female; Humans; Irritable Bowel Syndrome; Logistic Models; Male; Middle Aged; Nitric Oxide; Odds Ratio; Psychological Distress; ROC Curve

2021
Hyperuricemia induces endothelial dysfunction and accelerates atherosclerosis by disturbing the asymmetric dimethylarginine/dimethylarginine dimethylaminotransferase 2 pathway.
    Redox biology, 2021, Volume: 46

    Topics: Amidohydrolases; Animals; Arginine; Atherosclerosis; Endothelial Cells; Humans; Hyperuricemia; Mice; Nitric Oxide

2021
Comparative study of coronary artery bypass graft materials: reduced contraction and ADMA levels in internal mammary artery versus saphenous vein.
    The Journal of cardiovascular surgery, 2022, Volume: 63, Issue:1

    Topics: Arginine; Biomarkers; Coronary Artery Bypass; Humans; In Vitro Techniques; Mammary Arteries; Saphenous Vein; Vascular Patency; Vasoconstriction; Vasoconstrictor Agents

2022
Associations of circulating dimethylarginines with the metabolic syndrome in the Framingham Offspring study.
    PloS one, 2021, Volume: 16, Issue:9

    Topics: Arginine; Biomarkers; Cross-Sectional Studies; Female; Humans; Male; Metabolic Syndrome; Middle Aged; Prevalence; Prospective Studies; Tandem Mass Spectrometry

2021
Endothelial dysfunction biomarkers in sickle cell disease: is there a role for ADMA and PAI-1?
    Annals of hematology, 2022, Volume: 101, Issue:2

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Arginine; Biomarkers; Child; Cross-Sectional Studies; Endothelium; Female; Humans; Male; Plasminogen Activator Inhibitor 1; Severity of Illness Index; Young Adult

2022
Cholecalciferol and metformin protect against lipopolysaccharide-induced endothelial dysfunction and senescence by modulating sirtuin-1 and protein arginine methyltransferase-1.
    European journal of pharmacology, 2021, Dec-05, Volume: 912

    Topics: Antioxidants; Arginine; Cell Cycle Checkpoints; Cell Line; Cellular Senescence; Cholecalciferol; Endothelium; Homocysteine; Humans; Lipopolysaccharides; Metformin; Methylation; NAD; Nitric Oxide; Protective Agents; Protein-Arginine N-Methyltransferases; Repressor Proteins; S-Adenosylmethionine; Sirtuin 1; Telomerase; Vitamin D Response Element

2021
Effect of profilin-1 on the asymmetric dimethylarginine-induced vascular lesion-associated hypertension.
    The Kaohsiung journal of medical sciences, 2022, Volume: 38, Issue:2

    Topics: Animals; Arginine; Cell Proliferation; Endothelium, Vascular; Humans; Hypertension; Myocytes, Smooth Muscle; Profilins; Rats

2022
The Relationship of Thyroid Functions with ADMA, IMA, and Metabolic Laboratory Parameters in Euthyroid Adults with and without Autoimmune Thyroiditis.
    Laboratory medicine, 2022, May-05, Volume: 53, Issue:3

    Topics: Adult; Arginine; Biomarkers; Humans; Serum Albumin; Serum Albumin, Human; Thyroiditis, Autoimmune; Thyrotropin; Thyroxine

2022
Dysregulated Arginine Metabolism in Young Patients with Chronic Persistent Asthma and in Human Bronchial Epithelial Cells.
    Nutrients, 2021, Nov-17, Volume: 13, Issue:11

    Topics: Adult; Arginine; Asthma; Bronchi; Case-Control Studies; Cell Culture Techniques; Chronic Disease; Citrulline; Eosinophils; Epithelial Cells; Female; Humans; Male; Nitric Oxide; Ornithine; Prospective Studies; Young Adult

2021
Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation.
    Nature communications, 2022, 01-10, Volume: 13, Issue:1

    Topics: Amidohydrolases; Animals; Arginine; Bone and Bones; Female; Hydrolysis; Male; Mechanical Phenomena; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteogenesis

2022
Serum asymmetric dimethylarginine level correlates with the progression and prognosis of amyotrophic lateral sclerosis.
    European journal of neurology, 2022, Volume: 29, Issue:5

    Topics: Amyotrophic Lateral Sclerosis; Arginine; Biomarkers; Disease Progression; Humans; Nitric Oxide; Prognosis

2022
Association of asymmetric dimethylarginine with the pathological process of persistent pulmonary hypertension of the newborn.
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2022, Jan-15, Volume: 24, Issue:1

    Topics: Arginine; Biomarkers; Humans; Hypertension, Pulmonary; Infant, Newborn; Prospective Studies

2022
Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases.
    International journal of molecular sciences, 2022, Feb-15, Volume: 23, Issue:4

    Topics: Arginine; Asthma; Child; Dermatitis, Atopic; Female; Homoarginine; Humans; Male; Malondialdehyde; Nitrates; Nitric Oxide; Nitrites; Oxidative Stress; Signal Transduction

2022
A Therapeutic Extracorporeal Device for Specific Removal of Pathologic Asymmetric Dimethylarginine from the Blood.
    Blood purification, 2022, Volume: 51, Issue:11

    Topics: Animals; Arginine; Kidney Diseases; Swine

2022
Design and validation of an LC-MS/MS method for simultaneous quantification of asymmetric dimethylguanidino valeric acid, asymmetric dimethylarginine and symmetric dimethylarginine in human plasma.
    Pathology, 2022, Volume: 54, Issue:5

    Topics: Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Female; Humans; Male; Non-alcoholic Fatty Liver Disease; Tandem Mass Spectrometry

2022
Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling.
    Scientific reports, 2022, 06-07, Volume: 12, Issue:1

    Topics: Amidohydrolases; Animals; Aorta; Arginine; Blood Pressure; Mice; Transaminases; Vascular Diseases

2022
Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs.
    Pediatric research, 2022, Volume: 92, Issue:6

    Topics: Anticonvulsants; Arginine; Carotid Intima-Media Thickness; Child; Epilepsy; Homocysteine; Humans; Levetiracetam; Valproic Acid

2022
Asymmetric Dimethylarginine Protects Neurons from Oxygen Glucose Deprivation Insult by Modulating Connexin-36 Expression.
    Oxidative medicine and cellular longevity, 2022, Volume: 2022

    Topics: Animals; Arginine; Cells, Cultured; Connexins; Glucose; L-Lactate Dehydrogenase; Neurons; Nitric Oxide; Oxygen; Rats

2022
The ADMA-DDAH1 axis in ovarian apoptosis of polycystic ovary syndrome.
    The Journal of steroid biochemistry and molecular biology, 2023, Volume: 225

    Topics: Amidohydrolases; Animals; Apoptosis; Arginine; Dehydroepiandrosterone; Female; Humans; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Signal Transduction

2023
Asymmetric Dimethylarginine Is a Marker of Endothelial Dysfunction in Thrombotic Antiphospholipid Syndrome Patients.
    International journal of molecular sciences, 2022, Oct-14, Volume: 23, Issue:20

    Topics: Antiphospholipid Syndrome; Arginine; Biomarkers; C-Reactive Protein; Dilatation, Pathologic; Endothelium, Vascular; Humans; Nitroglycerin; Thrombosis; Vasodilation

2022
Increased Plasma L-Arginine Levels and L-Arginine/ADMA Ratios after Twelve Weeks of Omega-3 Fatty Acid Supplementation in Amateur Male Endurance Runners.
    Nutrients, 2022, Nov-10, Volume: 14, Issue:22

    Topics: Arginine; Dietary Supplements; Docosahexaenoic Acids; Fatty Acids, Omega-3; Humans; Male

2022
Asymmetric Dimethylarginine as a Biomarker in Coronary Artery Disease.
    Current topics in medicinal chemistry, 2023, Volume: 23, Issue:6

    Topics: Arginine; Atherosclerosis; Biomarkers; Coronary Artery Disease; Humans; Risk Factors

2023
The role of asymmetric dimethylarginine in endothelial dysfunction and abnormal nitric oxide metabolism in systemic sclerosis: results from a pilot study.
    Clinical rheumatology, 2023, Volume: 42, Issue:4

    Topics: Adult; Aged; Arginine; Atherosclerosis; Biomarkers; Carotid Intima-Media Thickness; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Nitric Oxide; Pilot Projects; Scleroderma, Systemic

2023
Asymmetric Dimethylarginine in an NMU-induced Rat Mammary Tumor Model.
    Anticancer research, 2023, Volume: 43, Issue:1

    Topics: Animals; Arginine; Female; Rats; Rats, Sprague-Dawley

2023
Association of serum ADMA, SDMA and L-NMMA concentrations with disease progression in COVID-19 patients.
    Biochemia medica, 2023, Feb-15, Volume: 33, Issue:1

    Topics: Arginine; COVID-19; Disease Progression; Humans; omega-N-Methylarginine

2023
Metabolite asymmetric dimethylarginine (ADMA) functions as a destabilization enhancer of SOX9 mediated by DDAH1 in osteoarthritis.
    Science advances, 2023, 02-10, Volume: 9, Issue:6

    Topics: Animals; Arginine; Mice; Ubiquitin-Specific Peptidase 7

2023
Urinary excretion of asymmetric (ADMA) and symmetric (SDMA) dimethylarginine is positively related to nitric oxide level in tissues of normotensive and hypertensive rats.
    Amino acids, 2023, Volume: 55, Issue:4

    Topics: Animals; Arginine; Chromatography, Liquid; Citrulline; Hypertension; Male; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tandem Mass Spectrometry

2023
Arginine, symmetric and asymmetric dimethylarginine levels in canine leishmaniasis.
    Microbial pathogenesis, 2023, Volume: 178

    Topics: Animals; Arginine; Creatinine; Dogs; Kidney; Leishmaniasis

2023
Association between asymmetric dimethylarginine and sarcopenia in community-dwelling older women.
    Scientific reports, 2023, 04-04, Volume: 13, Issue:1

    Topics: Aged; Arginine; Female; Humans; Independent Living; Sarcopenia; Vascular Diseases

2023
Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation.
    Cellular signalling, 2023, Volume: 107

    Topics: Arginine; HEK293 Cells; Humans; Lipids; Nitric Oxide Synthase; Receptors, Calcium-Sensing

2023
LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway.
    European journal of pharmacology, 2023, Jul-05, Volume: 950

    Topics: Amidohydrolases; Animals; Arginine; Endothelial Cells; Fibrosis; Forkhead Box Protein O1; Glucose; Humans; Rats; RNA, Long Noncoding; Signal Transduction

2023
Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2023, Nov-30, Volume: 38, Issue:12

    Topics: Arginine; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus; Diabetic Nephropathies; Heart Failure; Humans; Renal Insufficiency, Chronic

2023
The effect of exenatide (a GLP-1 analogue) and sitagliptin (a DPP-4 inhibitor) on asymmetric dimethylarginine (ADMA) metabolism and selected biomarkers of cardiac fibrosis in rats with fructose-induced metabolic syndrome.
    Biochemical pharmacology, 2023, Volume: 214

    Topics: Amidohydrolases; Animals; Arginine; Biomarkers; Chromatography, Liquid; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Fibrosis; Fructose; Glucagon-Like Peptide 1; Hypoglycemic Agents; Metabolic Syndrome; Nitric Oxide; Protease Inhibitors; Rats; Sitagliptin Phosphate; Tandem Mass Spectrometry

2023
The role of asymmetric dimethylarginine (ADMA) in COVID-19: association with respiratory failure and predictive role for outcome.
    Scientific reports, 2023, 06-17, Volume: 13, Issue:1

    Topics: Arginine; Biomarkers; COVID-19; Humans; Respiratory Insufficiency; RNA, Viral; SARS-CoV-2

2023