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n,n-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamide and pregnanolone

n,n-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamide has been researched along with pregnanolone in 7 studies

Compound Research Comparison

Studies
(n,n-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamide)
Trials
(n,n-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamide)
Recent Studies (post-2010)
(n,n-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamide)
Studies
(pregnanolone)
Trials
(pregnanolone)
Recent Studies (post-2010) (pregnanolone)
730301,984111666

Protein Interaction Comparison

ProteinTaxonomyn,n-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamide (IC50)pregnanolone (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.101
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.117
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.101
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.117
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.117
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.117
Gamma-aminobutyric acid receptor subunit alpha-1Mus musculus (house mouse)0.071
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.101
GABA theta subunitRattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.101

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's5 (71.43)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cheney, DL; Costa, E; Guidotti, A; Romeo, E; Zivkovic, I1
Audette, D; Bitran, D; Foley, M; Frye, CA; Leslie, N1
Chopde, CT; Jain, SP; Khisti, RT1
Chopde, CT; Deshpande, LS; Khisti, RT1
Frye, CA; Petralia, SM1
Frye, CA; Paris, JJ; Rhodes, ME1
Izumi, Y; O'Dell, KA; Tokuda, K; Zorumski, CF1

Other Studies

7 other study(ies) available for n,n-di-n-hexyl-2-(4-fluorophenyl)indole-3-acetamide and pregnanolone

ArticleYear
Mitochondrial diazepam-binding inhibitor receptor complex agonists antagonize dizocilpine amnesia: putative role for allopregnanolone.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:1

    Topics: Amnesia; Animals; Avoidance Learning; Cognition; Cognition Disorders; Dizocilpine Maleate; Indoleacetic Acids; Male; Mitochondria; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Scopolamine; Steroids; Tritium

1994
Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat.
    Psychopharmacology, 2000, Volume: 151, Issue:1

    Topics: Analysis of Variance; Animals; Anxiety; GABA Antagonists; Hippocampus; Indoleacetic Acids; Isoquinolines; Male; Mitochondria; Picrotoxin; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A

2000
Antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice forced swim test.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:1

    Topics: Animals; Antidepressive Agents; Benzodiazepinones; Bicuculline; Fluoxetine; Indoleacetic Acids; Male; Mice; Pregnanolone; Receptors, GABA-A; Swimming; Time Factors

2000
Cataleptic effect of neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice: modulation by serotonergic agents.
    Brain research, 2001, Apr-13, Volume: 898, Issue:1

    Topics: 5,7-Dihydroxytryptamine; Animals; Bicuculline; Catalepsy; Drug Synergism; Enzyme Inhibitors; GABA Antagonists; Indoleacetic Acids; Indomethacin; Male; Mice; Pregnanolone; Serotonin; Serotonin Agents; Serotonin Receptor Agonists; Synaptic Transmission

2001
In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters.
    Psychopharmacology, 2005, Volume: 178, Issue:2-3

    Topics: Animals; Central Nervous System Stimulants; Cricetinae; Drug Interactions; Estradiol; Female; GABA Antagonists; Indoleacetic Acids; Motor Activity; Picrotoxin; Pregnanolone; Progesterone; Rats; Rats, Long-Evans; Sexual Behavior, Animal; Stimulation, Chemical; Ventral Tegmental Area

2005
Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats.
    Reproduction (Cambridge, England), 2009, Volume: 137, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Exploratory Behavior; Female; Indoleacetic Acids; Indomethacin; Isoquinolines; Pregnanolone; Rats; Rats, Long-Evans; Sexual Behavior, Animal; Social Behavior; Ventral Tegmental Area

2009
Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Dec-15, Volume: 30, Issue:50

    Topics: Androstenols; Animals; Avoidance Learning; Carrier Proteins; Clonazepam; Excitatory Postsynaptic Potentials; Finasteride; Hippocampus; Indoleacetic Acids; Long-Term Potentiation; Male; Midazolam; Neurons; Neurotransmitter Agents; Pregnanolone; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

2010