n,n'-bis(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid and edetic acid

n,n'-bis(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid has been researched along with edetic acid in 43 studies

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (16.28)	18.7374
1990's	12 (27.91)	18.2507
2000's	13 (30.23)	29.6817
2010's	9 (20.93)	24.3611
2020's	2 (4.65)	2.80

Authors

Authors	Studies
Hauser, H; Hull, WE; Kalthoff, H; Klivényi, G; Maier-Borst, W; Matys, R; Matzku, S; Schmiegel, WH; Schuhmacher, J	1
Chitambar, CR; Lundberg, JH	1
Grady, RW; Hershko, C	2
Grady, RW; Hershko, C; Spira, DT; Theanacho, EN; Yinnon, AM	1
Bautovich, GJ; Hunt, FC; Maddalena, DJ; Wilson, JG	1
Hunt, FC	1
Chew, BP; Tanaka, TS; Tjoelker, LW	1
Cerny, EA; Lau, EH; Rahman, YE; Wright, BJ	1
Carnes, BA; Cerny, EA; Lau, EH; Rahman, YE	1
Grady, RW; Hershko, C; Link, G	1
Giardina, PJ; Grady, RW; Hilgartner, MW; Salbe, AD	1
Burnel, D; Graff, L; Muller, G	1
Hider, RC; Tilbrook, GS	1
Bergeron, RJ; Brittenham, GM; Wiegand, J	3
Hershko, C; Konijn, AM; Link, G	1
Donnelly, H; Faller, B; Fox, R; Lowther, N; Sergejew, T; Tomlinson, B	1
Faller, B; Sergejew, T; Spanka, C; Tschinke, V	1
Andrews, GK; Bittel, D; Hider, RC	1
Hoshino, H; Krokhin, OV; Kuzina, OV; Shpigun, OA; Yotsuyanagi, T	1
Hoshino, H; Krokhin, OV; Shpigun, OA; Yotsuyanagi, T	1
Afeworki, M; Brechbiel, MW; DeGraff, W; Krishna, MC; Mitchell, JB; Samuni, AM; Stein, W; Yordanov, AT	1
Cook, J	1
Clarke, JJ; Dunkel, VC; San, RH; Seifried, HE; Whittaker, P	1
Cunningham, S; Hillard, CJ; Kalivendi, SV; Kalyanaraman, B; Kotamraju, S; Shang, T	1
Bi, HP; Wang, JL; Yang, BS	1
Wang, Z; Yang, B	1
Incarvito, CD; Tinoco, AD; Valentine, AM	1
Jarrett, SG; Liang, LP; Patel, M	1
Hernández, D; López-Rayo, S; Lucena, JJ	1
Cook, JA; DeGraff, W; Fabre, KM; Krishna, MC; Mitchell, JB; Saito, K; Sowers, AL; Thetford, A	1
Incarvito, CD; Saghatelian, A; Thomas, HR; Tinoco, AD; Valentine, AM	1
Abboud, KA; Sloan, KB; Thiele, NA	1
Sloan, KB; Thiele, NA	1
Bin, LM; Bugter, MH; Weng, L	1
Campbell, A; Kumar, D; Langton, T; McCarthy, M	1
Hubble, D; Robins, P	1
Campbell, A; Francis, R; McCarthy, M; Tang, C; Watts, J	1
Klika, KD; Kopka, K; Litau, G; Makarem, A; Remde, Y	1
Can, C; Komek, H	1
Knutson, M; Lavin, SR; Livingston, S; Sullivan, KE; Valdes, EV; Warren, LK	1

Reviews

4 review(s) available for n,n'-bis(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid and edetic acid

Article	Year
An evaluation of the potential of HBED as an orally effective iron-chelating drug. Seminars in hematology, 1990, Volume: 27, Issue:2 Topics: Administration, Oral; Animals; Chelation Therapy; Chemical Phenomena; Chemistry; Edetic Acid; Female; Iron Chelating Agents; Male; Rats	1990
HBED: a potential oral iron chelator. Annals of the New York Academy of Sciences, 1990, Volume: 612 Topics: Administration, Oral; Animals; Blood Transfusion; Chelating Agents; Edetic Acid; Iron; Rats; Rats, Inbred Strains	1990
Iron chelators for clinical use. Metal ions in biological systems, 1998, Volume: 35 Topics: Biological Transport; Deferoxamine; Drug Delivery Systems; Edetic Acid; Ferric Compounds; Free Radical Scavengers; Humans; Iron; Iron Chelating Agents; Iron Overload; Ligands; Molecular Weight; Oxidation-Reduction; Pentetic Acid; Razoxane; Solubility; Structure-Activity Relationship; Tissue Distribution	1998
Iron chelators for thalassaemia. British journal of haematology, 1998, Volume: 101, Issue:3 Topics: Administration, Oral; Aza Compounds; Chelating Agents; Deferiprone; Deferoxamine; Edetic Acid; Humans; Iron; Iron Chelating Agents; Iron Overload; Long-Term Care; Pyridones; Thalassemia	1998

Trials

3 trial(s) available for n,n'-bis(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid and edetic acid

Article	Year
Results from a phase I clinical trial of HBED. Advances in experimental medicine and biology, 1994, Volume: 356 Topics: Adolescent; Adult; beta-Thalassemia; Chelating Agents; Deferoxamine; Edetic Acid; Female; Humans; Iron; Male; Transfusion Reaction	1994
A Multicenter Prospective Clinical Trial of International journal of radiation oncology, biology, physics, 2019, 07-15, Volume: 104, Issue:4 Topics: Aged; Aged, 80 and over; Antigens, Surface; Bone and Bones; Carcinoma; Cross-Sectional Studies; Edetic Acid; Gallium Isotopes; Gallium Radioisotopes; Glutamate Carboxypeptidase II; Humans; Kallikreins; Male; Middle Aged; Neoplasm Recurrence, Local; Oligopeptides; Pelvis; Positron Emission Tomography Computed Tomography; Prospective Studies; Prostate-Specific Antigen; Prostatectomy; Prostatic Neoplasms	2019
Safety and efficacy of a novel iron chelator (HBED; (N,N'-Di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid)) in equine (Equus caballus) as a model for black rhinoceros (Diceros bicornis). Journal of animal physiology and animal nutrition, 2022, Volume: 106, Issue:5 Topics: Acetates; Animals; Edetic Acid; Ethylenediamines; Horse Diseases; Horses; Iron; Iron Chelating Agents; Iron Overload; Perissodactyla	2022

Other Studies

36 other study(ies) available for n,n'-bis(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid and edetic acid

Article	Year
A bifunctional HBED-derivative for labeling of antibodies with 67Ga, 111In and 59Fe. Comparative biodistribution with 111In-DPTA and 131I-labeled antibodies in mice bearing antibody internalizing and non-internalizing tumors. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1992, Volume: 19, Issue:8 Topics: Animals; Antibodies, Monoclonal; Edetic Acid; Gallium Radioisotopes; Indium Radioisotopes; Iodine Radioisotopes; Iron Radioisotopes; Isotope Labeling; Magnetic Resonance Spectroscopy; Mice; Neoplasms, Experimental; Pentetic Acid	1992
Interaction of gallium nitrate with fludarabine and iron chelators: effects on the proliferation of human leukemic HL60 cells. Cancer research, 1990, Oct-15, Volume: 50, Issue:20 Topics: Antineoplastic Agents; Cell Division; Deferoxamine; Drug Synergism; Edetic Acid; Gallium; Humans; Iron; Iron Chelating Agents; Leukemia, Promyelocytic, Acute; Tumor Cells, Cultured; Vidarabine Phosphate	1990
Antimalarial effect of HBED and other phenolic and catecholic iron chelators. Blood, 1989, Nov-01, Volume: 74, Issue:6 Topics: Animals; Catechols; Chelating Agents; Edetic Acid; Erythrocytes; Female; Malaria; Phenols; Plasmodium berghei; Rats; Rats, Inbred Strains	1989
Phenolic aminocarboxylate chelates of 99mTc as hepatobiliary agents. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1986, Volume: 13, Issue:3 Topics: Animals; Edetic Acid; Ethylenediamines; Female; Gallbladder; Liver; Metabolic Clearance Rate; Radionuclide Imaging; Rats; Rats, Inbred Strains; Technetium	1986
Potential radiopharmaceuticals for the diagnosis of biliary atresia and neonatal hepatitis: EHPG and HBED chelates of 67Ga and 111In. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1988, Volume: 15, Issue:6 Topics: Animals; Biliary Atresia; Chelating Agents; Edetic Acid; Ethylenediamines; Female; Gallium Radioisotopes; Hepatitis; Humans; Indium Radioisotopes; Infant, Newborn; Male; Mice; Mice, Inbred BALB C; Rabbits; Radionuclide Imaging	1988
In vitro growth inhibition of mastitis causing bacteria by phenolics and metal chelators. Journal of dairy science, 1985, Volume: 68, Issue:11 Topics: Animals; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Cattle; Chelating Agents; Deferoxamine; Edetic Acid; Escherichia coli; Ethylenediamines; Female; Hydroquinones; In Vitro Techniques; Klebsiella pneumoniae; Mastitis, Bovine; Pentetic Acid; Phenols; Staphylococcus aureus; Streptococcus agalactiae	1985
Improvement of iron removal from the reticuloendothelial system by liposome encapsulation of N,N'-bis[2-hydroxybenzyl]-ethylenediamine-N,N'-diacetic acid (HBED). Comparison with desferrioxamine. The Journal of laboratory and clinical medicine, 1983, Volume: 101, Issue:5 Topics: Animals; Bile; Bile Canaliculi; Chelating Agents; Deferoxamine; Edetic Acid; Feces; Female; Iron; Kupffer Cells; Liposomes; Liver; Mice; Microscopy, Electron; Mononuclear Phagocyte System; Tissue Distribution	1983
Enhanced iron removal from liver parenchymal cells in experimental iron overload: liposome encapsulation of HBED and phenobarbital administration. Blood, 1983, Volume: 62, Issue:1 Topics: Animals; Deferoxamine; Edetic Acid; Feces; Ferritins; Iron; Liposomes; Liver; Mice; Phenobarbital	1983
Development and evaluation of the improved iron chelating agents EHPG, HBED and their dimethyl esters. Haematologia, 1984, Volume: 17, Issue:1 Topics: Administration, Oral; Animals; Deferoxamine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Edetic Acid; Ethylenediamines; Female; Infusions, Parenteral; Iron Chelating Agents; Iron Radioisotopes; Rats; Rats, Inbred Strains; Transfusion Reaction	1984
In vitro and in vivo evaluation of potential aluminum chelators. Veterinary and human toxicology, 1995, Volume: 37, Issue:5 Topics: Aluminum; Animals; Cadmium; Calcium; Chelating Agents; Citrates; Citric Acid; Copper; Edetic Acid; Ethylenediamines; In Vitro Techniques; Injections, Intraperitoneal; Iron; Male; Polarography; Rats; Solubility; Temperature; Zinc	1995
HBED: A potential alternative to deferoxamine for iron-chelating therapy. Blood, 1998, Feb-15, Volume: 91, Issue:4 Topics: Animals; Antidotes; Chelating Agents; Deferoxamine; Edetic Acid; Haplorhini; Iron Overload; Male; Rats; Rats, Sprague-Dawley; Transfusion Reaction	1998
Caco-2 cell permeability of a new (hydroxybenzyl)ethylenediamine oral iron chelator: correlation with physicochemical properties and oral activity. Journal of pharmaceutical sciences, 1998, Volume: 87, Issue:9 Topics: Administration, Oral; Animals; Caco-2 Cells; Callithrix; Cell Membrane Permeability; Edetic Acid; Humans; Iron; Iron Chelating Agents	1998
HBED: the continuing development of a potential alternative to deferoxamine for iron-chelating therapy. Blood, 1999, Jan-01, Volume: 93, Issue:1 Topics: Administration, Oral; Animals; Cebus; Deferoxamine; Edetic Acid; Injections, Intravenous; Injections, Subcutaneous; Iron; Iron Chelating Agents; Iron Overload; Iron-Dextran Complex; Male; Rats; Rats, Sprague-Dawley	1999
Improving the oral bioavailability of the iron chelator HBED by breaking the symmetry of the intramolecular H-bond network. Journal of medicinal chemistry, 2000, Apr-20, Volume: 43, Issue:8 Topics: Administration, Oral; Animals; Biological Availability; Callithrix; Edetic Acid; Feces; Hydrogen Bonding; Iron; Iron Chelating Agents; Molecular Conformation; Monte Carlo Method; Solubility; Solvents; Structure-Activity Relationship	2000
Competition between iron(III)-selective chelators and zinc-finger domains for zinc(II). Biochemical pharmacology, 1999, May-01, Volume: 57, Issue:9 Topics: Animals; Binding, Competitive; Deferiprone; DNA-Binding Proteins; Edetic Acid; Iron; Iron Chelating Agents; Mice; Pyridones; Recombinant Proteins; Transcription Factor MTF-1; Transcription Factors; Zinc; Zinc Fingers	1999
Potential of ethylenediaminedi(o-hydroxyphenylacetic acid) and N,N'-bis(hydroxybenzyl)ethylenediamine-N,N'-diacetic acid for the determination of metal ions by capillary electrophoresis. Journal of chromatography. A, 2000, Aug-25, Volume: 890, Issue:2 Topics: Cations; Edetic Acid; Electrophoresis, Capillary; Ethylenediamines; Metals; Oxidation-Reduction	2000
Separation selectivity of anionic metal complexes of N,N'-bis(hydroxybenzyl)ethylenediamine-N,N'-diacetic acid in ion and ion electrokinetic chromatography. Journal of chromatography. A, 2000, Oct-20, Volume: 895, Issue:1-2 Topics: Anions; Chromatography, Micellar Electrokinetic Capillary; Edetic Acid; Hydrogen-Ion Concentration; Metals; Sensitivity and Specificity	2000
Multifunctional antioxidant activity of HBED iron chelator. Free radical biology & medicine, 2001, Jan-15, Volume: 30, Issue:2 Topics: Animals; Antioxidants; Benzothiazoles; Cell Death; Cell Line; Cell Survival; Chromans; Cricetinae; Cricetulus; Cyclic N-Oxides; Cytoprotection; Edetic Acid; Electron Spin Resonance Spectroscopy; Hydrogen; Hydrogen Peroxide; Hydroxyl Radical; Iron Chelating Agents; Oxidation-Reduction; Oxygen; Phenols; Spectrophotometry; Spin Labels; Sulfonic Acids; Superoxides; tert-Butylhydroperoxide	2001
Radiation sensitization of mammalian cells by metal chelators. Radiation research, 2001, Volume: 155, Issue:2 Topics: Animals; Cell Cycle; Chelating Agents; Colony-Forming Units Assay; Cricetinae; Cricetulus; Deferiprone; Deferoxamine; DNA Replication; Edetic Acid; Fibroblasts; Genes, p53; Humans; Iron Chelating Agents; Lung; Lung Neoplasms; Mimosine; Pyridones; Radiation-Sensitizing Agents; S Phase; Tumor Cells, Cultured	2001
Genotoxicity of iron chelators in L5178Y mouse lymphoma cells. Environmental and molecular mutagenesis, 2001, Volume: 38, Issue:4 Topics: Animals; Deferiprone; Edetic Acid; Iron Chelating Agents; Lymphoma; Mice; Mutagenicity Tests; Phenanthrolines; Pyridones; Razoxane; Tumor Cells, Cultured	2001
HBED ligand: preclinical studies of a potential alternative to deferoxamine for treatment of chronic iron overload and acute iron poisoning. Blood, 2002, Apr-15, Volume: 99, Issue:8 Topics: Acute Disease; Animals; Blood Pressure; Cebus; Chronic Disease; Deferoxamine; Disease Models, Animal; Dogs; Drug Administration Routes; Drug Evaluation, Preclinical; Edetic Acid; Heart Rate; Iron; Iron Chelating Agents; Iron Overload; Male; Poisoning; Rats; Rats, Sprague-Dawley; Therapeutic Equivalency	2002
1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide. The Biochemical journal, 2003, Apr-01, Volume: 371, Issue:Pt 1 Topics: 1-Methyl-4-phenylpyridinium; Aconitate Hydratase; Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Deferoxamine; Edetic Acid; Female; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Hydrogen Peroxide; Iron; Iron Chelating Agents; Male; Metalloporphyrins; Mitochondria; NADH, NADPH Oxidoreductases; Neurons; Oxidants; Oxidative Stress; Parkinson Disease; Reactive Oxygen Species; Receptors, Transferrin; Staining and Labeling; Transferrin	2003
[Determination on conditional equilibrium constants of the complexes of Gd(III) and Yb(III) with HBED by UV difference spectra]. Guang pu xue yu guang pu fen xi = Guang pu, 2005, Volume: 25, Issue:1 Topics: Algorithms; Edetic Acid; Gadolinium; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Molecular Structure; Organometallic Compounds; Spectrophotometry, Ultraviolet; Temperature; Thermodynamics; Ytterbium	2005
UV and fluorescence spectral changes induced by neodymium binding of N,N'-ethylenebis[2-(o-hydroxyphenolic)glycine] and N,N'-di(2-hydroxybenzyl)ethylenediamine-N,N' diacetic acid. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2006, Volume: 65, Issue:3-4 Topics: Edetic Acid; Ethylenediamines; Fluorescence; Iron Chelating Agents; Neodymium; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Ultraviolet Rays	2006
Calorimetric, spectroscopic, and model studies provide insight into the transport of Ti(IV) by human serum transferrin. Journal of the American Chemical Society, 2007, Mar-21, Volume: 129, Issue:11 Topics: Binding Sites; Calorimetry; Chelating Agents; Crystallography, X-Ray; Edetic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Organometallic Compounds; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Titanium; Transferrin	2007
Chelation of mitochondrial iron prevents seizure-induced mitochondrial dysfunction and neuronal injury. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Nov-05, Volume: 28, Issue:45 Topics: Analysis of Variance; Animals; Behavior, Animal; Bleomycin; Chelating Agents; Colorimetry; Disease Models, Animal; DNA, Mitochondrial; Edetic Acid; Fluoresceins; Glutathione; Glutathione Disulfide; Hippocampus; Iron; Kainic Acid; Male; Mitochondrial Diseases; Organic Chemicals; Rats; Rats, Sprague-Dawley; Status Epilepticus; Subcellular Fractions; Time Factors	2008
Chemical evaluation of HBED/Fe(3+) and the novel HJB/Fe(3+) chelates as fertilizers to alleviate iron chlorosis. Journal of agricultural and food chemistry, 2009, Sep-23, Volume: 57, Issue:18 Topics: Adsorption; Calcium; Copper; Drug Stability; Edetic Acid; Ferric Compounds; Fertilizers; Iron; Iron Chelating Agents; Magnesium; Models, Molecular; Plant Diseases; Soil; Solubility; Solutions	2009
The effects of resveratrol and selected metabolites on the radiation and antioxidant response. Cancer biology & therapy, 2011, Nov-15, Volume: 12, Issue:10 Topics: Animals; Antioxidants; Cell Cycle; Cell Survival; Dose-Response Relationship, Drug; Edetic Acid; Female; Fibroblasts; Humans; Hydrogen Peroxide; Mice; Mice, Inbred C3H; Oxidative Stress; Phenols; Quinones; Radiation-Protective Agents; Resveratrol; Stilbenes; tert-Butylhydroperoxide; Whole-Body Irradiation	2011
Cytotoxicity of a Ti(IV) compound is independent of serum proteins. Proceedings of the National Academy of Sciences of the United States of America, 2012, Mar-27, Volume: 109, Issue:13 Topics: Blood Proteins; Cell Death; Cell Line, Tumor; Chelating Agents; Chromatography, Liquid; Crystallography, X-Ray; Dimethylformamide; Drug Screening Assays, Antitumor; Edetic Acid; Humans; Hydrogen-Ion Concentration; Mass Spectrometry; Potentiometry; Serum Albumin; Spectrophotometry; Titanium; Transferrin	2012
Novel double prodrugs of the iron chelator N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid (HBED): Synthesis, characterization, and investigation of activation by chemical hydrolysis and oxidation. European journal of medicinal chemistry, 2016, Aug-08, Volume: 118 Topics: Boronic Acids; Cell Membrane Permeability; Copper; Edetic Acid; Hydrolysis; Iron; Iron Chelating Agents; Oxidation-Reduction; Prodrugs; Solubility; Water	2016
A Double Prodrug with Improved Membrane Permeability over the Parent Chelator HBED Provides Superior Cytoprotection against Hydrogen Peroxide. ChemMedChem, 2016, 08-05, Volume: 11, Issue:15 Topics: Boronic Acids; Cell Line; Cell Membrane Permeability; Diffusion; Edetic Acid; Humans; Hydrogen Peroxide; Hydrolysis; Iron Chelating Agents; Oxidation-Reduction; Prodrugs; Protective Agents; Solubility	2016
Effectiveness of FeEDDHA, FeEDDHMA, and FeHBED in Preventing Iron-Deficiency Chlorosis in Soybean. Journal of agricultural and food chemistry, 2016, Nov-09, Volume: 64, Issue:44 Topics: Chlorophyll; Edetic Acid; Ethylenediamines; Fertilizers; Glycine max; Iron; Iron Chelating Agents; Manganese; Plant Diseases; Soil; Spain	2016
Comparison of PSMA-HBED and PSMA-I&T as diagnostic agents in prostate carcinoma. European journal of nuclear medicine and molecular imaging, 2017, Volume: 44, Issue:9 Topics: Aged; Edetic Acid; Gallium Isotopes; Gallium Radioisotopes; Humans; Male; Middle Aged; Neoplasm Metastasis; Oligopeptides; Positron Emission Tomography Computed Tomography; Prostatic Neoplasms	2017
RE: Uptake in sympathetic ganglia on 68Ga-PSMA-HBED PET/CT: A potential pitfall in scan interpretation. Journal of medical imaging and radiation oncology, 2018, Volume: 62, Issue:3 Topics: Edetic Acid; Ganglia, Sympathetic; Positron Emission Tomography Computed Tomography	2018
HBED-NN: A Bifunctional Chelator for Constructing Radiopharmaceuticals. The Journal of organic chemistry, 2019, 06-07, Volume: 84, Issue:11 Topics: Chelating Agents; Edetic Acid; Gallium; Humans; Molecular Structure; Neoplasms; Radiopharmaceuticals	2019
Contribution of 5th minute and 2nd hour images to standard imaging in ( Annals of nuclear medicine, 2020, Volume: 34, Issue:3 Topics: Aged; Aged, 80 and over; Antigens, Surface; Bone Neoplasms; Edetic Acid; Gallium Radioisotopes; Glutamate Carboxypeptidase II; Humans; Lymph Nodes; Male; Middle Aged; Positron Emission Tomography Computed Tomography; Prostatic Neoplasms; Radiopharmaceuticals	2020