Page last updated: 2024-09-02

n-monodemethyldiltiazem and midazolam

n-monodemethyldiltiazem has been researched along with midazolam in 2 studies

Compound Research Comparison

Studies (n-monodemethyldiltiazem)	Trials (n-monodemethyldiltiazem)	Recent Studies (post-2010) (n-monodemethyldiltiazem)	Studies (midazolam)	Trials (midazolam)	Recent Studies (post-2010) (midazolam)
30	3	1	9,834	3,191	3,301

Protein Interaction Comparison

Protein	Taxonomy	n-monodemethyldiltiazem (IC50)	midazolam (IC50)
Cytochrome P450 3A4	Homo sapiens (human)		2.7427

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Dalvie, D; Loi, CM; Smith, DA	1
Gorski, JC; Hall, SD; Jones, DR; Quinney, SK; Zhang, X	1

Trials

1 trial(s) available for n-monodemethyldiltiazem and midazolam

Article	Year
Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite. Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:8 Topics: Administration, Oral; Adult; Biotransformation; Computer Simulation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Drug Interactions; Enzyme Inhibitors; Female; Humans; Infusions, Intravenous; Intestinal Absorption; Intestines; Liver; Male; Midazolam; Models, Biological; Nonlinear Dynamics; Prospective Studies; Reproducibility of Results; Young Adult	2009

Article

Year

Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite.

Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:8

Topics: Administration, Oral; Adult; Biotransformation; Computer Simulation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Drug Interactions; Enzyme Inhibitors; Female; Humans; Infusions, Intravenous; Intestinal Absorption; Intestines; Liver; Male; Midazolam; Models, Biological; Nonlinear Dynamics; Prospective Studies; Reproducibility of Results; Young Adult

2009

Other Studies

1 other study(ies) available for n-monodemethyldiltiazem and midazolam

Article	Year
Which metabolites circulate? Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations	2013