Compounds > n-methylscopolamine
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n-methylscopolamine and xanomeline

n-methylscopolamine has been researched along with xanomeline in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (14.29)18.2507
2000's8 (57.14)29.6817
2010's3 (21.43)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Christopoulos, A; El-Fakahany, EE; Pierce, TL; Sorman, JL1
Dolezal, V; El-Fakahany, EE; Jakubík, J1
Bernhardt, G; Gmeiner, P; Hübner, H; Keller, M; Pegoli, A; She, X; Wifling, D1
Bernhardt, G; Carpenter, J; Chen, M; Gmeiner, P; Gruber, CG; Holliday, ND; Hübner, H; Keller, M; Pegoli, A; She, X; Wan, J; Wifling, D1
Christopoulos, A; El-Fakahany, EE; Parsons, AM1
El-Fakahany, EE; Jakubík, J; Tucek, S1
El-Fakahany, EE; Grant, MK1
De Lorme, KC; El-Fakahany, EE; Grant, MK; Sikorski, KL1
Dolezal, V; El-Fakahany, EE; Jakubík, J; Machová, E1
De Lorme, KC; El-Fakahany, EE; Grant, MK; Noetzel, MJ; Polson, SB1
El-Fakahany, EE; Grant, MK; Noetzel, MJ2
Doležal, V; El-Fakahany, EE; Jakubík, J; Šantrůčková, E1
Abelson, KS; Jørgensen, KB; Kanui, TI; Krogh-Jensen, K; Pickering, DS1

Other Studies

14 other study(ies) available for n-methylscopolamine and xanomeline

ArticleYear
On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor.
    Molecular pharmacology, 1998, Volume: 53, Issue:6

    Topics: Animals; Atropine; Carbachol; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Muscarinic Agonists; N-Methylscopolamine; Nitric Oxide Synthase; Phosphatidylinositols; Pyridines; Receptor, Muscarinic M1; Receptors, Muscarinic; Thiadiazoles; Time Factors

1998
Differences in kinetics of xanomeline binding and selectivity of activation of G proteins at M(1) and M(2) muscarinic acetylcholine receptors.
    Molecular pharmacology, 2006, Volume: 70, Issue:2

    Topics: Animals; Carbachol; CHO Cells; Cricetinae; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Muscarinic Agonists; N-Methylscopolamine; Pyridines; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Thiadiazoles

2006
Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M
    Journal of medicinal chemistry, 2017, 04-27, Volume: 60, Issue:8

    Topics: Benzodiazepinones; Binding Sites; Molecular Dynamics Simulation; Muscarinic Antagonists; Radioisotopes; Receptor, Muscarinic M2

2017
Red-Emitting Dibenzodiazepinone Derivatives as Fluorescent Dualsteric Probes for the Muscarinic Acetylcholine M
    Journal of medicinal chemistry, 2020, 04-23, Volume: 63, Issue:8

    Topics: Animals; CHO Cells; Cholinergic Agents; Cricetulus; Fluorescent Dyes; Muscarinic Antagonists; Phthalimides; Protein Structure, Secondary; Quaternary Ammonium Compounds; Receptor, Muscarinic M2

2020
Pharmacological analysis of the novel mode of interaction between xanomeline and the M1 muscarinic acetylcholine receptor.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:3

    Topics: Animals; Atropine; Binding, Competitive; Carbachol; CHO Cells; Citrulline; Cricetinae; Humans; Kinetics; Muscarinic Agonists; N-Methylscopolamine; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pirenzepine; Pyridines; Radioligand Assay; Receptor, Muscarinic M1; Receptors, Muscarinic; Recombinant Proteins; Thiadiazoles; Transfection; Tritium

1999
Allosteric modulation by persistent binding of xanomeline of the interaction of competitive ligands with the M1 muscarinic acetylcholine receptor.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 301, Issue:3

    Topics: Allosteric Regulation; Animals; Atropine; Binding, Competitive; Buffers; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Kinetics; Ligands; Muscarinic Agonists; N-Methylscopolamine; Pyridines; Receptor, Muscarinic M1; Receptors, Muscarinic; Thiadiazoles; Tritium

2002
Persistent binding and functional antagonism by xanomeline at the muscarinic M5 receptor.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:1

    Topics: Animals; Carbachol; CHO Cells; Cricetinae; Inositol Phosphates; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Pilocarpine; Pyridines; Receptor, Muscarinic M5; Thiadiazoles

2005
Long-term wash-resistant effects of brief interaction of xanomeline at the M1 muscarinic receptor.
    Neuroscience letters, 2006, Dec-13, Volume: 410, Issue:1

    Topics: Animals; Atropine; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Drug Interactions; Humans; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Pyridines; Receptor, Muscarinic M1; Thiadiazoles; Time Factors; Transfection; Tritium

2006
Wash-resistantly bound xanomeline inhibits acetylcholine release by persistent activation of presynaptic M(2) and M(4) muscarinic receptors in rat brain.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:1

    Topics: Acetylcholine; Animals; Cerebral Cortex; CHO Cells; Cricetinae; Cricetulus; Humans; Male; Muscarinic Agonists; N-Methylscopolamine; Norepinephrine; Pyridines; Rats; Rats, Wistar; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Thiadiazoles

2007
Long-term changes in the muscarinic M1 receptor induced by instantaneous formation of wash-resistant xanomeline-receptor complex.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 323, Issue:3

    Topics: Allosteric Site; Animals; Binding, Competitive; Carbachol; Cells, Cultured; Cricetinae; Cricetulus; Female; Humans; Inositol Phosphates; Ligands; Muscarinic Agonists; N-Methylscopolamine; Ovary; Protein Binding; Pyridines; Radioligand Assay; Receptor, Muscarinic M1; Thiadiazoles; Time Factors; Transfection

2007
Immediate and delayed consequences of xanomeline wash-resistant binding at the M3 muscarinic receptor.
    Neurochemical research, 2009, Volume: 34, Issue:6

    Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Hydrolysis; Inositol Phosphates; Muscarinic Agonists; Muscarinic Antagonists; N-Methylscopolamine; Phosphatidylinositols; Pyridines; Radioligand Assay; Receptor, Muscarinic M3; Thiadiazoles; Time Factors

2009
Mechanisms of M3 muscarinic receptor regulation by wash-resistant xanomeline binding.
    Pharmacology, 2009, Volume: 83, Issue:5

    Topics: Animals; Atropine; Binding Sites; Carbachol; Cell Line, Transformed; Cricetinae; Drug Interactions; Female; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Muscarinic Agonists; N-Methylscopolamine; Phosphatidylinositols; Pilocarpine; Pyridines; Quinuclidinyl Benzilate; Receptor, Muscarinic M3; Thiadiazoles; Time Factors; Transfection

2009
Long-term activation upon brief exposure to xanomleline is unique to M1 and M4 subtypes of muscarinic acetylcholine receptors.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: Animals; Binding Sites; Calcium; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Extracellular Space; Humans; Intracellular Space; Kinetics; N-Methylscopolamine; Pyridines; Receptor, Muscarinic M1; Receptor, Muscarinic M4; Thiadiazoles; Time Factors

2014
Investigation of the presence and antinociceptive function of muscarinic acetylcholine receptors in the African naked mole-rat (Heterocephalus glaber).
    Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2016, Volume: 202, Issue:1

    Topics: Animals; Female; Formaldehyde; Male; Mole Rats; Muscarinic Agonists; N-Methylscopolamine; Nociception; Pyridines; Radioligand Assay; Radiopharmaceuticals; Receptors, Muscarinic; Spinal Cord; Thiadiazoles; Thiophenes; Tritium

2016