Page last updated: 2024-08-25

n-methylscopolamine and piperidines

n-methylscopolamine has been researched along with piperidines in 61 studies

Research

Studies (61)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (22.95)	18.7374
1990's	33 (54.10)	18.2507
2000's	12 (19.67)	29.6817
2010's	2 (3.28)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Akerman, KE; Hämäläinen, H; Heikkilä, J; Kukkonen, J; Näsman, J; Ojala, P	1
Endou, M; Gando, S; Hattori, Y; Kanno, M	1
Aasen, A; Camus, J; Christophe, J; Lambrecht, G; Mutschler, E; Schjelderup, L; Strohmann, C; Tacke, R; Tastenoy, M; Waelbroeck, M	1
Endou, M; Gandou, S; Hattori, Y; Kanno, M; Nakaya, H	1
Akerman, KE; Kukkonen, J	1
Kajimura, M; Reuben, MA; Sachs, G	1
Ehlert, FJ; Thomas, EA	1
Brann, MR; Gdula, D; Wess, J	1
Ehlert, FJ; Griffin, MT; Hsu, HH; Hunter, AL; Luong, T; Thomas, EA	1
Camus, J; Christophe, J; Tastenoy, M; Waelbroeck, M	2
Pechnick, RN; Vargas, HM	1
Hasler, WL; Heldsinger, A; Owyang, C	1
Hersey, SJ; Kajimura, M; Sachs, G; Scott, DR; Wilkes, JM	1
Endou, M	1
Yang, CM	1
Bartfai, T; Grabczewska, E; Maslinski, W; Ryzewski, J	1
Hanack, C; Herawi, M; Kopp, R; Lambrecht, G; Moser, U; Mutschler, E; Pfeiffer, A; Tacke, R	1
Caldirola, P; Hacksell, U; Lundkvist, JR; Ringdahl, B; Vargas, HM	1
Alonso, R; Didier, M; Soubrie, P	1
el-Fakahany, EE; Lee, NH	1
Louie, DS; Owyang, C	1
Amrhein, CL; el-Fakahany, EE; Forray, C; Surichamorn, W	1
Fleckenstein, P; Müller, WE; Riemann, D; Stoll, L	1
Brown, DA; Marrion, NV; Marsh, SJ; Smart, TG	1
Hsu, CT; Hyman, PE; Jing, J; Snape, WJ; Tomomasa, T	1
Delmendo, RE; Michel, AD; Whiting, RL	1
Camus, J; Christophe, J; Waelbroeck, M; Winand, J	1
Bieger, D; Triggle, C	1
Giraldo, E; Hammer, R; Ladinsky, H; Viganò, MA	1
Bali, JP; Baudiere, B; Giraldo, E; Ladinsky, H; Monferini, E	1
Benyajati, C	1
Henis, YI; Schreiber, G; Sokolovsky, M	1
Henis, YI; Sokolovsky, M	1
Gossuin, A; Laduron, P; Maloteaux, JM; Trouet, A	1
Maggio, R; Nanavati, S; Vogel, Z; Wess, J	1
Blüml, K; Mutschler, E; Wess, J	1
Camus, J; Christophe, J; Kropfgans, M; Lambrecht, G; Mutschler, E; Sperlich, J; Tacke, R; Tastenoy, M; Waelbroeck, M; Wiesenberger, F	1
Chen, FF; Hsu, HF; Sung, TC; Wu, D; Yang, CM	1
Hootman, SR; Kovalcik, SA; Zukerman, J	1
Maggio, R; Vogel, Z; Wess, J	1
Consolo, S; Garcia Ruiz, AJ; La Porta, C; Ladinsky, H; Zambelli, M	1
Bado, A; Cherifi, Y; Laigneau, JP; Lewin, MJ; Moizo, L	1
Ehlert, FJ; Griffin, MT; Oliff, HS	1
Potter, LT; Purkerson, SL	1
Go, ML; Sim, MK; Xu, R	1
Lu, Y; Shi, H; Wang, H; Wang, Z; Yang, B	1
Ehlert, FJ; Lambrecht, G; Sawyer, GW	1
Havlas, Z; Lysíková, M; Tucek, S	1
Christopoulos, A; Wilson, K	1
Branch, CL; Christopoulos, A; Forbes, IT; Fry, VA; Herdon, HJ; Langmead, CJ; Wood, MD	1
Arias-Montaño, JA; Sánchez-Lemus, E	1
Braeter, M; Hakenberg, OW; Kelly, LU; Ravens, U; Waelbroeck, M; Weiss, A; Wuest, M	1
Dolezal, V; Iivonen, H; Jakubík, J; Machová, E; Michal, P; Oksman, M; Tanila, H	1
Jasper, JR; Mammen, M; Smith, JA; Steinfeld, T; Wilson, RD	1
Avlani, VA; Christopoulos, A; Herdon, HJ; Langmead, CJ; May, LT; Sexton, PM; Wood, MD	1
Huang, TJ; Ko, WC; Lin, LH; Lin, YL; Wang, SH; Wu, SN	1
Andreani, A; Bedini, A; Burnelli, S; Fazio, N; Granaiola, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Spampinato, S; Varoli, L	1
Challiss, RA; Langmead, CJ; Mistry, R; Thomas, RL; Wood, MD	1
Araki, I; Ehlert, FJ; Masuyama, K; Nasrin, S; Otsuka, A; Ozono, S; Seki, M; Takeda, M; Yamada, S; Yoshida, A	1
Bernhardt, G; Buschauer, A; Keller, M; Pegoli, A; Read, RW; She, X; Tränkle, C	1

Other Studies

61 other study(ies) available for n-methylscopolamine and piperidines

Article	Year
Muscarinic receptor subtypes in human neuroblastoma cell lines SH-SY5Y and IMR-32 as determined by receptor binding, Ca++ mobilization and northern blotting. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:3 Topics: Blotting, Northern; Calcium; Humans; N-Methylscopolamine; Neuroblastoma; Phosphatidylinositols; Piperidines; Pirenzepine; Radioligand Assay; Receptors, Muscarinic; RNA, Messenger; Scopolamine Derivatives; Tumor Cells, Cultured	1992
Selectivity of class I antiarrhythmic agents, disopyramide, pirmenol, and pentisomide for peripheral muscarinic M2 and M3 receptors. Journal of cardiovascular pharmacology, 1992, Volume: 19, Issue:5 Topics: Animals; Anti-Arrhythmia Agents; Binding, Competitive; Disopyramide; Female; Guinea Pigs; Kinetics; Male; Muscle, Smooth; N-Methylscopolamine; Piperidines; Propylamines; Pyridines; Receptors, Muscarinic; Scopolamine Derivatives; Submandibular Gland; Urinary Bladder	1992
Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors. European journal of pharmacology, 1992, Sep-01, Volume: 227, Issue:1 Topics: Alkynes; Animals; Corpus Striatum; Heart; Humans; In Vitro Techniques; Male; N-Methylscopolamine; Neuroblastoma; Pancreas; Parasympatholytics; Piperidines; Procyclidine; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Stereoisomerism; Tritium	1992
Electrophysiologic and anticholinergic effects of pirmenol enantiomers in guinea-pig myocardium. Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 346, Issue:5 Topics: Action Potentials; Animals; Electrophysiology; Guinea Pigs; Heart; In Vitro Techniques; Kinetics; Membrane Potentials; Membranes; Myocardium; N-Methylscopolamine; Papillary Muscles; Parasympatholytics; Piperidines; Radioligand Assay; Receptors, Muscarinic; Scopolamine Derivatives; Stereoisomerism	1992
Apparent noncompetitive antagonism of muscarinic receptor mediated Ca2+ mobilization by some muscarinic antagonists. Biochemical and biophysical research communications, 1992, Dec-15, Volume: 189, Issue:2 Topics: Atropine; Calcium; Fura-2; Humans; Kinetics; Muscarinic Antagonists; N-Methylscopolamine; Neuroblastoma; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Spectrometry, Fluorescence; Tumor Cells, Cultured	1992
The muscarinic receptor gene expressed in rabbit parietal cells is the m3 subtype. Gastroenterology, 1992, Volume: 103, Issue:3 Topics: Animals; Atropine; Base Sequence; Blotting, Southern; Molecular Sequence Data; N-Methylscopolamine; Parietal Cells, Gastric; Piperidines; Pirenzepine; Polymerase Chain Reaction; Rabbits; Receptors, Muscarinic; RNA, Messenger; Scopolamine Derivatives	1992
Irreversible effects of 4-DAMP mustard on muscarinic receptors in vivo. Proceedings of the Western Pharmacology Society, 1992, Volume: 35 Topics: Alkylating Agents; Animals; Diphenylacetic Acids; Male; N-Methylscopolamine; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives	1992
Structural basis of the subtype selectivity of muscarinic antagonists: a study with chimeric m2/m5 muscarinic receptors. Molecular pharmacology, 1992, Volume: 41, Issue:2 Topics: Alkaloids; Amino Acid Sequence; Benzodiazepinones; Chimera; Dibenzazepines; Furans; Humans; Molecular Sequence Data; Muscarinic Antagonists; N-Methylscopolamine; Naphthalenes; Parasympatholytics; Piperazines; Piperidines; Receptors, Muscarinic; Scopolamine Derivatives; Sequence Homology, Nucleic Acid	1992
Conversion of N-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-DAMP mustard) to an aziridinium ion and its interaction with muscarinic receptors in various tissues. Molecular pharmacology, 1992, Volume: 41, Issue:4 Topics: Alkylation; Animals; Aziridines; Binding Sites; Brain; Diphenylacetic Acids; Drug Interactions; Hydrogen-Ion Concentration; Ileum; In Vitro Techniques; Kinetics; Male; Myocardium; N-Methylscopolamine; Oxotremorine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Submandibular Gland; Temperature	1992
Binding properties of nine 4-diphenyl-acetoxy-N-methyl-piperidine (4-DAMP) analogues to M1, M2, M3 and putative M4 muscarinic receptor subtypes. British journal of pharmacology, 1992, Volume: 105, Issue:1 Topics: Allosteric Regulation; Animals; Corpus Striatum; In Vitro Techniques; Male; Myocardium; N-Methylscopolamine; Neuroblastoma; Pancreas; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Structure-Activity Relationship; Temperature; Tumor Cells, Cultured	1992
Binding affinity and antimuscarinic activity of sigma and phencyclidine receptor ligands. European journal of pharmacology, 1991, Mar-19, Volume: 195, Issue:1 Topics: Animals; Binding, Competitive; Carbachol; Cerebral Cortex; Dioxolanes; Guinea Pigs; Haloperidol; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Parasympatholytics; Pentazocine; Phosphatidylinositols; Piperidines; Receptors, Muscarinic; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Phencyclidine; Scopolamine Derivatives	1991
Cisapride acts on muscarinic (glandular M2) receptors to induce contraction of isolated gastric myocytes: mediation via a calcium-phosphoinositide pathway. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:3 Topics: Adenylyl Cyclases; Animals; Calcium; Cells, Cultured; Cisapride; Gastric Mucosa; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Phosphatidylinositols; Piperidines; Receptors, Muscarinic; Receptors, Serotonin; Scopolamine Derivatives; Second Messenger Systems; Serotonin Antagonists; Signal Transduction; Stomach; Tritium	1991
Muscarinic responses of gastric parietal cells. The Journal of membrane biology, 1991, Volume: 122, Issue:2 Topics: Aminopyrine; Animals; Arachidonic Acids; Calcium; Carbachol; Glucose; Image Processing, Computer-Assisted; Ionomycin; N-Methylscopolamine; Parasympatholytics; Parietal Cells, Gastric; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives; Tritium	1991
[Pharmacological analysis of drug interactions of disopyramide and its congeners with peripheral muscarinic acetylcholine receptors]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1991, Volume: 66, Issue:5 Topics: Animals; Binding, Competitive; Carbachol; Disopyramide; Drug Interactions; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Myocardial Contraction; N-Methylscopolamine; Piperidines; Propylamines; Pyridines; Receptors, Muscarinic; Scopolamine Derivatives	1991
Characterization of muscarinic receptors in dog tracheal smooth muscle cells. Journal of autonomic pharmacology, 1991, Volume: 11, Issue:1 Topics: Animals; Atropine; Carbachol; Diamines; Dogs; In Vitro Techniques; Kinetics; Muscle, Smooth; N-Methylscopolamine; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Trachea	1991
Muscarinic antagonist binding to intact rat thymocytes. Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 1990, Volume: 44, Issue:2 Topics: Animals; Atropine; Benzilates; Kinetics; Male; Muscarine; N-Methylscopolamine; Piperidines; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Thymus Gland	1990
Human gastric mucosa expresses glandular M3 subtype of muscarinic receptors. Digestive diseases and sciences, 1990, Volume: 35, Issue:12 Topics: Carbachol; Gastric Mucosa; Humans; In Vitro Techniques; N-Methylscopolamine; Parasympatholytics; Piperazines; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives	1990
Resolved pyrrolidine, piperidine, and perhydroazepine analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. Journal of medicinal chemistry, 1990, Volume: 33, Issue:12 Topics: Animals; Azepines; Binding, Competitive; Cerebral Cortex; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; Magnetic Resonance Spectroscopy; Male; Molecular Conformation; Molecular Structure; Muscle Contraction; N-Methylscopolamine; Parasympathomimetics; Piperidines; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Stereoisomerism	1990
[3H]N-methylscopolamine binding studies reveal M2 and M3 muscarinic receptor subtypes on cerebellar granule cells in primary culture. Journal of neurochemistry, 1990, Volume: 55, Issue:1 Topics: Animals; Atropine; Binding, Competitive; Cell Survival; Cells, Cultured; Cerebellum; Diamines; Granulocytes; N-Methylscopolamine; Parasympatholytics; Piperidines; Pirenzepine; Receptors, Muscarinic; Scopolamine Derivatives; Tritium	1990
The allosteric binding profile of himbacine: a comparison with other cardioselective muscarinic antagonists. European journal of pharmacology, 1990, Apr-10, Volume: 179, Issue:1-2 Topics: Alkaloids; Allosteric Regulation; Animals; Atropine; Binding, Competitive; Diamines; Dose-Response Relationship, Drug; Furans; Gallamine Triethiodide; Male; Myocardium; N-Methylscopolamine; Naphthalenes; Piperidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives	1990
Binding of selective antagonists to four muscarinic receptors (M1 to M4) in rat forebrain. Molecular pharmacology, 1990, Volume: 38, Issue:2 Topics: Alkaloids; Animals; Brain; Diamines; Furans; Humans; Hybrid Cells; N-Methylscopolamine; Naphthalenes; Parasympatholytics; Piperidines; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Tumor Cells, Cultured	1990
Muscarinic receptor subtypes on rat pancreatic acini: secretion and binding studies. The American journal of physiology, 1986, Volume: 251, Issue:2 Pt 1 Topics: Acetylcholine; Amylases; Animals; Benzodiazepinones; Binding Sites; Male; N-Methylscopolamine; Pancreas; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Tritium	1986
Inhibition of cyclic AMP formation in N1E-115 neuroblastoma cells is mediated by a non-cardiac M2 muscarinic receptor subtype. Brain research, 1989, Jul-31, Volume: 493, Issue:2 Topics: Animals; Binding, Competitive; Cyclic AMP; Mice; Muscarinic Antagonists; N-Methylscopolamine; Neuroblastoma; Piperidines; Receptors, Muscarinic; Scopolamine Derivatives; Tumor Cells, Cultured	1989
A simple but highly sensitive radioreceptor assay for the determination of scopolamine and biperiden in human plasma. Research communications in chemical pathology and pharmacology, 1989, Volume: 64, Issue:1 Topics: Animals; Biperiden; Brain Chemistry; Humans; Male; Mice; N-Methylscopolamine; Piperidines; Radioligand Assay; Scopolamine; Scopolamine Derivatives	1989
Muscarinic suppression of the M-current in the rat sympathetic ganglion is mediated by receptors of the M1-subtype. British journal of pharmacology, 1989, Volume: 98, Issue:2 Topics: Animals; Calcium; Gallamine Triethiodide; Ganglia, Spinal; Ganglia, Sympathetic; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Piperidines; Pirenzepine; Potassium Channels; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives	1989
Development of the muscarinic receptor in rabbit gastric smooth muscle. The American journal of physiology, 1988, Volume: 254, Issue:5 Pt 1 Topics: Animals; Animals, Newborn; Atropine; Bethanechol; Bethanechol Compounds; Dose-Response Relationship, Drug; Kinetics; Muscle Contraction; Muscle Development; Muscle, Smooth; N-Methylscopolamine; Phenethylamines; Piperidines; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives; Stomach	1988
Affinity of muscarinic receptor antagonists for three putative muscarinic receptor binding sites. British journal of pharmacology, 1989, Volume: 96, Issue:2 Topics: Animals; Buffers; Cerebral Cortex; In Vitro Techniques; Male; Myocardium; N-Methylscopolamine; Parasympatholytics; Piperidines; Pirenzepine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Submandibular Gland	1989
Different antagonist binding properties of rat pancreatic and cardiac muscarinic receptors. Life sciences, 1987, Nov-09, Volume: 41, Issue:19 Topics: Animals; Binding, Competitive; GTP-Binding Proteins; Kinetics; Male; Myocardium; N-Methylscopolamine; Pancreas; Parasympatholytics; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Type C Phospholipases	1987
Pharmacological properties of mechanical responses of the rat oesophageal muscularis mucosae to vagal and field stimulation. British journal of pharmacology, 1985, Volume: 84, Issue:1 Topics: Animals; Dioxolanes; Electric Stimulation; Esophagus; Hexamethonium Compounds; In Vitro Techniques; Ketanserin; Male; Morphine; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Naloxone; Piperidines; Rats; Rats, Inbred Strains; Scopolamine Derivatives; Serotonin; Tetrodotoxin; Tubocurarine; Vagus Nerve	1985
Characterization of muscarinic receptors in guinea pig ileum longitudinal smooth muscle. Molecular pharmacology, 1988, Volume: 33, Issue:6 Topics: Animals; Binding, Competitive; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Muscle, Smooth; Myocardium; N-Methylscopolamine; Parasympatholytics; Phenoxybenzamine; Piperidines; Pirenzepine; Receptors, Muscarinic; Salivary Glands; Scopolamine Derivatives	1988
Characterization of the muscarinic receptor subtype in isolated gastric fundic cells of the rabbit. Biochemical pharmacology, 1987, Sep-15, Volume: 36, Issue:18 Topics: Aminopyrine; Animals; Atropine; Carbachol; Gastric Fundus; Kinetics; Male; N-Methylscopolamine; Piperidines; Pirenzepine; Rabbits; Receptors, Muscarinic; Scopolamine Derivatives	1987
Comparative study of Baralgan and hyoscine-N-methyl bromide in the treatment of intestinal and renal colicy pain. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1986, Volume: 69, Issue:10 Topics: Adolescent; Adult; Aminopyrine; Benzophenones; Colic; Dipyrone; Drug Combinations; Female; Humans; Intestinal Diseases; Kidney Diseases; Male; Middle Aged; N-Methylscopolamine; Parasympatholytics; Piperidines; Scopolamine Derivatives	1986
Analysis of ligand binding to receptors by competition kinetics. Application to muscarinic antagonists in rat brain cortex. The Journal of biological chemistry, 1985, Jul-25, Volume: 260, Issue:15 Topics: Animals; Benzilates; Binding, Competitive; Cerebral Cortex; In Vitro Techniques; Kinetics; Male; N-Methylscopolamine; Parasympatholytics; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives	1985
Muscarinic antagonists induce different receptor conformations in rat adenohypophysis. Molecular pharmacology, 1983, Volume: 24, Issue:3 Topics: Allosteric Regulation; Animals; Benzilates; Binding, Competitive; In Vitro Techniques; Male; Models, Chemical; N-Methylscopolamine; Parasympatholytics; Piperidines; Pituitary Gland, Anterior; Protein Conformation; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Scopolamine Derivatives	1983
Differentiation between ligand trapping into intact cells and binding on muscarinic receptors. Biochimica et biophysica acta, 1984, May-22, Volume: 804, Issue:1 Topics: Animals; Biological Transport; Cell Line; Cell Membrane; Dexetimide; Glioma; Ligands; Lysosomes; N-Methylscopolamine; Neuroblastoma; Piperidines; Quinuclidines; Quinuclidinyl Benzilate; Receptors, Muscarinic; Scopolamine Derivatives	1984
Functional role of proline and tryptophan residues highly conserved among G protein-coupled receptors studied by mutational analysis of the m3 muscarinic receptor. The EMBO journal, 1993, Volume: 12, Issue:1 Topics: Acetylcholine; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Blotting, Northern; Carbachol; Cell Line; Codon; GTP-Binding Proteins; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylscopolamine; Parasympatholytics; Piperidines; Proline; Protein Conformation; Rats; Receptors, Muscarinic; Recombinant Proteins; Restriction Mapping; RNA; Scopolamine Derivatives; Transfection; Tryptophan	1993
Insertion mutagenesis as a tool to predict the secondary structure of a muscarinic receptor domain determining specificity of G-protein coupling. Proceedings of the National Academy of Sciences of the United States of America, 1994, Aug-16, Volume: 91, Issue:17 Topics: Acetylcholine; Amino Acid Sequence; Animals; Binding Sites; Carbachol; Cell Line; Chlorocebus aethiops; GTP-Binding Proteins; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Insertional; N-Methylscopolamine; Phosphatidylinositols; Piperidines; Protein Structure, Secondary; Rats; Receptors, Muscarinic; Recombinant Proteins; Scopolamine Derivatives; Transfection	1994
Thermodynamics of antagonist binding to rat muscarinic M2 receptors: antimuscarinics of the pridinol, sila-pridinol, diphenidol and sila-diphenidol type. British journal of pharmacology, 1993, Volume: 109, Issue:2 Topics: Animals; Heart; Histamine H1 Antagonists; In Vitro Techniques; Male; N-Methylscopolamine; Parasympatholytics; Piperidines; Rats; Rats, Inbred WKY; Receptors, Muscarinic; Scopolamine Derivatives; Stereoisomerism; Thermodynamics	1993
Pharmacological characterization of muscarinic receptors in neonatal rat cardiomyocytes. The American journal of physiology, 1993, Volume: 265, Issue:3 Pt 1 Topics: Animals; Animals, Newborn; Cells, Cultured; Cyclic AMP; Inositol Phosphates; Kinetics; Muscarine; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic; Scopolamine Derivatives	1993
Muscarinic receptors in isolated guinea pig pancreatic ducts. Biochemical pharmacology, 1993, Jul-20, Volume: 46, Issue:2 Topics: Amidohydrolases; Animals; Binding, Competitive; Guinea Pigs; In Vitro Techniques; Male; Molecular Weight; N-Methylscopolamine; Pancreatic Ducts; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase; Piperidines; Propylbenzilylcholine Mustard; Receptors, Muscarinic; Scopolamine Derivatives; Tritium	1993
Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors. Proceedings of the National Academy of Sciences of the United States of America, 1993, Apr-01, Volume: 90, Issue:7 Topics: Acetylcholine; Animals; Carbachol; Cell Line; GTP-Binding Proteins; Kinetics; Models, Structural; N-Methylscopolamine; Parasympatholytics; Phosphatidylinositols; Piperidines; Protein Structure, Secondary; Rats; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Recombinant Fusion Proteins; Scopolamine Derivatives; Signal Transduction; Transfection; Yohimbine	1993
Differences between rat dorsal and ventral hippocampus in muscarinic receptor agonist binding and interaction with phospholipase C. European journal of pharmacology, 1993, Jan-15, Volume: 244, Issue:2 Topics: Alkaloids; Animals; Carbachol; Furans; Guanylyl Imidodiphosphate; Hippocampus; Male; Membranes; Mitochondria; N-Methylscopolamine; Naphthalenes; Oxotremorine; Parasympatholytics; Parasympathomimetics; Phosphatidylinositols; Piperidines; Pirenzepine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Synaptosomes; Type C Phospholipases	1993
H3-receptor activation inhibits cholinergic stimulation of acid secretion in isolated rabbit fundic glands. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:3 Topics: Animals; Carbachol; Cholinergic Antagonists; Gastric Acid; Gastric Fundus; Gastric Mucosa; Histamine Agonists; Histamine Antagonists; In Vitro Techniques; Methylhistamines; Muscarinic Antagonists; N-Methylscopolamine; Piperidines; Rabbits; Ranitidine; Receptors, Histamine H3; Receptors, Muscarinic; Scopolamine Derivatives	1995
The quaternary transformation products of N-(3-chloropropyl)-4-piperidinyl diphenylacetate and N-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-DAMP mustard) have differential affinity for subtypes of the muscarinic receptor. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 276, Issue:2 Topics: Animals; CHO Cells; Cricetinae; Diphenylacetic Acids; Male; Muscarinic Antagonists; N-Methylscopolamine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Scopolamine Derivatives	1996
Use of antimuscarinic toxins to facilitate studies of striatal m4 muscarinic receptors. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:2 Topics: Alkaloids; Animals; Benzodiazepines; Binding, Competitive; Cats; CHO Cells; Corpus Striatum; Cricetinae; Elapid Venoms; Furans; Gallamine Triethiodide; Humans; Male; Muscarinic Antagonists; N-Methylscopolamine; Naphthalenes; Neurotoxins; Piperidines; Pirenzepine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptor, Muscarinic M4; Receptors, Muscarinic; Recombinant Proteins	1998
Synthesis and pharmacological characterization of O-alkynyloximes of tropinone and N-methylpiperidinone as muscarinic agonists. Journal of medicinal chemistry, 1998, Aug-13, Volume: 41, Issue:17 Topics: Animals; Aorta; Binding, Competitive; Drug Design; Escape Reaction; In Vitro Techniques; Male; Maze Learning; Mice; Models, Molecular; Molecular Structure; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth, Vascular; N-Methylscopolamine; Nuclear Magnetic Resonance, Biomolecular; Piperidines; Pirenzepine; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Structure-Activity Relationship; Tropanes	1998
Pilocarpine modulates the cellular electrical properties of mammalian hearts by activating a cardiac M3 receptor and a K+ current. British journal of pharmacology, 1999, Volume: 126, Issue:8 Topics: Action Potentials; Animals; Atrial Function; Binding, Competitive; Dogs; Electrophysiology; Female; Guinea Pigs; Heart; Heart Atria; Heart Rate; Male; Membrane Potentials; Microelectrodes; Muscarinic Agonists; Muscarinic Antagonists; Myocardium; N-Methylscopolamine; Parasympatholytics; Pilocarpine; Piperidines; Potassium Channels; Receptor, Muscarinic M3; Receptors, Muscarinic; Time Factors	1999
Functional role of muscarinic M(2) receptors in alpha,beta-methylene ATP induced, neurogenic contractions in guinea-pig ileum. British journal of pharmacology, 2000, Volume: 129, Issue:7 Topics: Adenosine Triphosphate; Animals; Diphenylacetic Acids; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; N-Methylscopolamine; Pertussis Toxin; Piperidines; Pirenzepine; Receptor, Muscarinic M2; Receptors, Muscarinic; Tetrodotoxin; Virulence Factors, Bordetella	2000
Interactions between allosteric modulators and 4-DAMP and other antagonists at muscarinic receptors: potential significance of the distance between the N and carboxyl C atoms in the molecules of antagonists. Neurochemical research, 2001, Volume: 26, Issue:4 Topics: Alcuronium; Allosteric Regulation; Animals; CHO Cells; Cricetinae; Muscarinic Antagonists; N-Methylscopolamine; Piperidines; Radioligand Assay; Strychnine; Tritium	2001
Interaction of anandamide with the M(1) and M(4) muscarinic acetylcholine receptors. Brain research, 2001, Oct-05, Volume: 915, Issue:1 Topics: Acetylcholine; Animals; Arachidonic Acids; Binding Sites; Binding, Competitive; Brain; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; CHO Cells; Cricetinae; Endocannabinoids; Memory; Muscarinic Antagonists; N-Methylscopolamine; Parasympatholytics; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Quinuclidinyl Benzilate; Radioligand Assay; Receptor, Muscarinic M1; Receptor, Muscarinic M4; Receptors, Cannabinoid; Receptors, Drug; Receptors, Muscarinic; Rimonabant; Tritium	2001
Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist. Molecular pharmacology, 2006, Volume: 69, Issue:1 Topics: Allosteric Regulation; Animals; Calcium; CHO Cells; Cricetinae; Molecular Probes; Muscarinic Agonists; N-Methylscopolamine; Piperidines; Radioligand Assay; Receptor, Muscarinic M1	2006
M1 muscarinic receptors contribute to, whereas M4 receptors inhibit, dopamine D1 receptor-induced [3H]-cyclic AMP accumulation in rat striatal slices. Neurochemical research, 2006, Volume: 31, Issue:4 Topics: Alkaloids; Animals; Benzazepines; Carbachol; Cholinergic Agonists; Corpus Striatum; Cyclic AMP; Dopamine Agonists; Furans; Male; Muscarinic Antagonists; N-Methylscopolamine; Naphthalenes; Parasympatholytics; Piperidines; Pirenzepine; Protein Kinase C; Radioligand Assay; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptor, Muscarinic M4; Receptors, Dopamine D1	2006
Propiverine and metabolites: differences in binding to muscarinic receptors and in functional models of detrusor contraction. Naunyn-Schmiedeberg's archives of pharmacology, 2006, Volume: 374, Issue:2 Topics: Animals; Benzilates; Binding, Competitive; Calcium; Carbachol; Cell Line; Cells, Cultured; CHO Cells; Cholinergic Antagonists; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Electric Stimulation; Epithelial Cells; Humans; Molecular Structure; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Parasympatholytics; Piperidines; Potassium Chloride; Receptors, Muscarinic; Urinary Bladder	2006
Impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mice. Neurobiology of aging, 2008, Volume: 29, Issue:3 Topics: Acetylcholinesterase; Age Factors; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Animals, Genetically Modified; Dose-Response Relationship, Drug; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mice; Mutation; N-Methylscopolamine; Piperidines; Presenilin-1; Protein Binding; Receptors, Muscarinic; Synaptic Transmission; Vesicular Acetylcholine Transport Proteins	2008
A novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M2 muscarinic receptor. Molecular pharmacology, 2007, Volume: 72, Issue:2 Topics: Allosteric Site; Animals; Benzeneacetamides; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Ligands; Muscarinic Antagonists; N-Methylscopolamine; Obidoxime Chloride; Piperidines; Radioligand Assay; Receptor, Muscarinic M2	2007
Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors. Molecular pharmacology, 2007, Volume: 72, Issue:2 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Allosteric Regulation; Allosteric Site; Animals; CHO Cells; Cricetinae; Cricetulus; Muscarinic Agonists; N-Methylscopolamine; Piperidines; Receptor, Muscarinic M2; Structure-Activity Relationship	2007
Bronchodilatory effects of S-isopetasin, an antimuscarinic sesquiterpene of Petasites formosanus, on obstructive airway hyperresponsiveness. European journal of pharmacology, 2008, Apr-28, Volume: 584, Issue:2-3 Topics: Acetylcholine; Animals; Atropine; Binding, Competitive; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents; Cells, Cultured; Cholinesterase Inhibitors; Diamines; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Ipratropium; Male; Muscarinic Antagonists; Muscle, Smooth; N-Methylscopolamine; Neostigmine; Petasites; Piperidines; Protein Binding; Receptor, Muscarinic M3; Sesquiterpenes; Time Factors; Trachea	2008
Diphenidol-related diamines as novel muscarinic M4 receptor antagonists. Bioorganic & medicinal chemistry letters, 2008, May-01, Volume: 18, Issue:9 Topics: Allosteric Regulation; Animals; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Diamines; Humans; Kinetics; Muscarinic Antagonists; N-Methylscopolamine; Piperidines; Radioligand Assay; Receptor, Muscarinic M4; Staining and Labeling; Structure-Activity Relationship	2008
G protein coupling and signaling pathway activation by m1 muscarinic acetylcholine receptor orthosteric and allosteric agonists. The Journal of pharmacology and experimental therapeutics, 2008, Volume: 327, Issue:2 Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Protein alpha Subunits, Gs; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol 1,4,5-Trisphosphate; Muscarinic Agonists; N-Methylscopolamine; Piperidines; Quinolones; Receptor, Muscarinic M1; Signal Transduction	2008
Characterization of muscarinic receptors in the human bladder mucosa: direct quantification of subtypes using 4-DAMP mustard. Urology, 2011, Volume: 78, Issue:3 Topics: Aged; Aged, 80 and over; Binding, Competitive; Diphenylacetic Acids; Humans; In Vitro Techniques; Male; Middle Aged; Mucous Membrane; Muscarinic Antagonists; Muscle, Smooth; N-Methylscopolamine; Parotid Gland; Piperidines; Radioligand Assay; Receptors, Muscarinic; Urinary Bladder	2011
M2 Subtype preferring dibenzodiazepinone-type muscarinic receptor ligands: Effect of chemical homo-dimerization on orthosteric (and allosteric?) binding. Bioorganic & medicinal chemistry, 2015, Jul-15, Volume: 23, Issue:14 Topics: Allosteric Site; Animals; Benzodiazepinones; Chemistry Techniques, Synthetic; CHO Cells; Cricetulus; Dimerization; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Ligands; N-Methylscopolamine; Piperidines; Radioligand Assay; Receptor, Muscarinic M2; Structure-Activity Relationship	2015