n-methylcytisine and 2-hydroxypyridine

Novel derivatives of 4-oxo-3-methylcytisine with phenyl moiety bonded to starting molecule through various spacers were obtained from the 9-amino, -halo, -formyl and 11-halo precursors by reductive alkylation of amines, generation of amide, as well as thio- and carboxamide functions, cross-coupling reactions, aldehyde condensation and reduction of unsaturated 'C-C' bonds. Ability of synthesized compounds to influence the learning and memory was preliminary assessed in conditioned passive avoidance reflex (CPAR) test in rats. It was shown, that derivatives with phenyl group at 11 carbon atom influence the learning and memory in CPAR test more effectively than other compounds. The hit-compound (3-methyl-11-(2-phenylvinyl)-3,5,6-trihydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocine-4,8(1H)-dione) with the best values of 'latency' and 'time spent in the dark compartment' has been identified as a perspective scaffold for synthesis of novel derivatives of (-)-cytisine with potential neuropharmacological activity.

Topics: Aldehydes; Alkaloids; Animals; Avoidance Learning; Conditioning, Classical; Drug Evaluation, Preclinical; Male; Pyridones; Quinolizines; Rats; Reflex; Structure-Activity Relationship

The first direct synthesis of 3-

Topics: Aldehydes; Alkaloids; Azocines; Formates; Hydroxylamines; Magnetic Resonance Spectroscopy; Nitrogen Oxides; Oximes; Pyridones; Quinolizines