Page last updated: 2024-08-22

n-methylaspartate and pregnanolone

n-methylaspartate has been researched along with pregnanolone in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (20.00)18.2507
2000's7 (35.00)29.6817
2010's7 (35.00)24.3611
2020's2 (10.00)2.80

Authors

AuthorsStudies
Baulieu, EE; Mahé, V; Monnet, FP; Robel, P1
Farb, DH; Marek, P; Park-Chung, M; Tam, SW; Weaver, CE1
Farb, DH; Gibbs, TT; Malayev, AA; Park-Chung, M; Purdy, RH; Wu, FS1
Bowen, CA; Gatto, GJ; Grant, KA1
Bidziński, A; Członkowska, AI; Krzaścik, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J1
Boustany, RM; Lockhart, EM; Mehrabani, S; Pearlstein, RD; Penning, DH; Warner, DS1
Bregonzio, C; Cabrera, RJ; Laconi, M; Mampel, A1
Farb, DH; Gibbs, TT; Janis, GC; Johnson, DW; Pierce, RC; Sadri-Vakili, G1
Papazafiri, P; Xilouri, M1
Avlonitis, N; Calogeropoulou, T; Papazafiri, P; Xilouri, M1
Budziszewska, B; Jantas, D; Lason, W; Leskiewicz, M1
Aoki, C; Fenton, AA; Sabaliauskas, N; Shen, H; Sherpa, A; Smith, SS; Stelzer, A1
Cabrera, R; Giuliani, FA; Laconi, M; Mohn, CE; Rettori, V; Yunes, R1
Agustí, A; Cauli, O; Felipo, V; González-Usano, A1
Cirrito, JR; Goebel, WD; Holtzman, DM; Restivo, JL; Verges, DK1
Li, XH; Liu, HL; Wang, G; Xia, SH; Zhang, XC1
Cao, Z; Hagerman, PJ; Hagerman, RJ; Hulsizer, S; Pessah, IN; Rogawski, MA; Tang, HT; Tassone, F1
Ko, TS; Lee, M; Velíšek, L; Yum, MS1
Chodounska, H; Chvojkova, M; Kudova, E; Rambousek, L; Vales, K1
Chern, CJ; Chern, CR; Chodounská, H; Kudová, E; Lauková, M; Schonwald, A; Shakarjian, MP; Velíšek, L; Velíšková, J1

Other Studies

20 other study(ies) available for n-methylaspartate and pregnanolone

ArticleYear
Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Apr-25, Volume: 92, Issue:9

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Female; Guanidines; Haloperidol; Hippocampus; Kinetics; N-Methylaspartate; Norepinephrine; Ovariectomy; Pertussis Toxin; Piperazines; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Stereotaxic Techniques; Virulence Factors, Bordetella

1995
Neuroprotective activity of a new class of steroidal inhibitors of the N-methyl-D-aspartate receptor.
    Proceedings of the National Academy of Sciences of the United States of America, 1997, Sep-16, Volume: 94, Issue:19

    Topics: Animals; Anticonvulsants; Chick Embryo; Culture Techniques; Excitatory Amino Acid Antagonists; Hippocampus; Hypnotics and Sedatives; Male; Mice; N-Methylaspartate; Neuroprotective Agents; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures; Spinal Cord; Succinates

1997
Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids.
    Molecular pharmacology, 1997, Volume: 52, Issue:6

    Topics: Animals; Arachidonic Acid; Binding Sites; Binding, Competitive; Cells, Cultured; Chick Embryo; Hippocampus; N-Methylaspartate; Neurons; Oxidation-Reduction; Polyamines; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Structure-Activity Relationship; Xenopus laevis

1997
Assessment of the multiple discriminative stimulus effects of ethanol using an ethanol-pentobarbital-water discrimination in rats.
    Behavioural pharmacology, 1997, Volume: 8, Issue:4

    Topics: Animals; Central Nervous System Depressants; Diazepam; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; GABA Modulators; Hypnotics and Sedatives; Indoles; Male; Midazolam; Morphine; N-Methylaspartate; Narcotics; Pentobarbital; Phencyclidine; Pregnanolone; Quinoxalines; Rats; Rats, Long-Evans; Serotonin Receptor Agonists; Water

1997
The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:2

    Topics: Animals; Bicuculline; Central Nervous System Depressants; Convulsants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Picrotoxin; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Reflex; Seizures; Sleep; Steroids

2000
Allopregnanolone attenuates N-methyl-D-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture.
    Neuroscience letters, 2002, Aug-02, Volume: 328, Issue:1

    Topics: Apoptosis; Asphyxia Neonatorum; Benzimidazoles; Carbocyanines; Cell Count; Cell Survival; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Fluorescent Dyes; Humans; Hypoxia-Ischemia, Brain; In Situ Nick-End Labeling; Infant, Newborn; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondria; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Pregnancy; Pregnanolone; Progesterone; Tumor Cells, Cultured

2002
Allopregnanolone increase in striatal N-methyl-D-aspartic acid evoked [3H]dopamine release is estrogen and progesterone dependent.
    Cellular and molecular neurobiology, 2002, Volume: 22, Issue:4

    Topics: Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Estrogens; Female; N-Methylaspartate; Ovariectomy; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Tritium

2002
Inhibition of NMDA-induced striatal dopamine release and behavioral activation by the neuroactive steroid 3alpha-hydroxy-5beta-pregnan-20-one hemisuccinate.
    Journal of neurochemistry, 2003, Volume: 86, Issue:1

    Topics: Animals; Behavior, Animal; Corpus Striatum; Dopamine; Excitatory Amino Acid Agonists; Injections, Intraperitoneal; Male; Microdialysis; Microinjections; Motor Activity; N-Methylaspartate; Pregnanolone; Rats; Rats, Sprague-Dawley; Steroids; Succinates

2003
Anti-apoptotic effects of allopregnanolone on P19 neurons.
    The European journal of neuroscience, 2006, Volume: 23, Issue:1

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Bicuculline; Blotting, Northern; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cytochromes c; Cytosol; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Drug Interactions; Fluorescent Antibody Technique; GABA Antagonists; Mice; Mitochondria; N-Methylaspartate; Neurons; Pregnanolone; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synaptophysin; Time Factors; Tubulin

2006
Neuroprotective effects of steroid analogues on P19-N neurons.
    Neurochemistry international, 2007, Volume: 50, Issue:4

    Topics: Animals; Apoptosis; Cells, Cultured; Dehydroepiandrosterone; Gene Expression Regulation; Mice; Molecular Structure; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Pregnanolone; Proto-Oncogene Proteins c-akt; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Steroids

2007
Excitatory neurosteroids attenuate apoptotic and excitotoxic cell death in primary cortical neurons.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2008, Volume: 59, Issue:3

    Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Death; Cerebral Cortex; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Enzyme Inhibitors; Excitatory Amino Acids; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Neurotransmitter Agents; Phosphoinositide-3 Kinase Inhibitors; Pregnanolone; Pregnenolone; Reactive Oxygen Species; Staurosporine; Steroids

2008
A critical role for alpha4betadelta GABAA receptors in shaping learning deficits at puberty in mice.
    Science (New York, N.Y.), 2010, Mar-19, Volume: 327, Issue:5972

    Topics: Animals; CA1 Region, Hippocampal; Dendrites; Dendritic Spines; Excitatory Postsynaptic Potentials; Female; GABA-A Receptor Antagonists; Learning; Long-Term Potentiation; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neural Inhibition; Patch-Clamp Techniques; Pregnanolone; Pyramidal Cells; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Sexual Maturation; Spatial Behavior

2010
Allopregnanolone induces LHRH and glutamate release through NMDA receptor modulation.
    Endocrine, 2011, Volume: 40, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Estrogen Replacement Therapy; Female; Glutamic Acid; Gonadotropin-Releasing Hormone; Hypothalamus; In Vitro Techniques; Models, Animal; N-Methylaspartate; Neurotransmitter Agents; Ovariectomy; Pregnanolone; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

2011
Differential modulation of the glutamate-nitric oxide-cyclic GMP pathway by distinct neurosteroids in cerebellum in vivo.
    Neuroscience, 2011, Sep-08, Volume: 190

    Topics: Animals; Cerebellum; Cyclic GMP; Dehydroepiandrosterone; gamma-Aminobutyric Acid; Glutamic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Nitric Oxide; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Signal Transduction

2011
Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Aug-03, Volume: 31, Issue:31

    Topics: Action Potentials; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Brain Waves; Calcium; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Electroencephalography; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Extracellular Space; Flavones; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; N-Methylaspartate; Piperazines; Piperidines; Pregnanolone; Presenilin-1; Receptors, N-Methyl-D-Aspartate; Serotonin; Sodium Channel Blockers; Synapses; Tetrodotoxin

2011
[Effects of neuroactive steroid allopregnanolone on the damage of cortical neurons].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2011, Volume: 27, Issue:2

    Topics: Animals; Animals, Newborn; Apoptosis; Caspase 3; Caspase 9; Cerebral Cortex; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Pregnanolone; Primary Cell Culture; Receptors, GABA-B; RNA, Messenger

2011
Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone.
    Human molecular genetics, 2012, Jul-01, Volume: 21, Issue:13

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Excitatory Amino Acid Antagonists; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA Plasma Membrane Transport Proteins; Gene Knock-In Techniques; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Pregnanolone; Receptor, Metabotropic Glutamate 5; Receptors, Glutamate; Receptors, Metabotropic Glutamate; RNA, Messenger; Trinucleotide Repeat Expansion

2012
A potential effect of ganaxolone in an animal model of infantile spasms.
    Epilepsy research, 2014, Volume: 108, Issue:9

    Topics: Age Factors; Anesthetics; Animals; Animals, Newborn; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Agonists; Exploratory Behavior; Female; Humans; Infant; Male; N-Methylaspartate; Pregnanolone; Rats; Rats, Sprague-Dawley; Reaction Time; Social Behavior; Spasms, Infantile; Statistics, Nonparametric

2014
Synthetic structural modifications of neurosteroid pregnanolone sulfate: Assessment of neuroprotective effects in vivo.
    European journal of pharmacology, 2020, Aug-15, Volume: 881

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Locomotion; Male; Maze Learning; Mice; Molecular Structure; Motor Activity; N-Methylaspartate; Neuroprotective Agents; Pregnanolone; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Sulfates

2020
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
    Pharmacological reports : PR, 2023, Volume: 75, Issue:1

    Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnanolone; Pyrrolidonecarboxylic Acid; Rodentia; Spasm; Spasms, Infantile

2023