n-methylaspartate has been researched along with piperidines in 230 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (7.83) | 18.7374 |
| 1990's | 86 (37.39) | 18.2507 |
| 2000's | 80 (34.78) | 29.6817 |
| 2010's | 42 (18.26) | 24.3611 |
| 2020's | 4 (1.74) | 2.80 |
| Authors | Studies |
|---|---|
| Nicklas, WJ; Zeevalk, GD | 2 |
| Butler, TW; Chenard, BL; Prochniak, MA; Shalaby, IA | 1 |
| Harms, J; Woodward, JJ | 1 |
| Darles, G; Graham, D; Langer, SZ | 1 |
| Hariton, C | 1 |
| Fukamauchi, F; Shibuya, H; Yoshikawa, T | 1 |
| Blier, P; de Montigny, C; Debonnel, G; Monnet, FP | 1 |
| Duval, D; Gauffeny, C; Nowicki, JP; Roome, N; Scatton, B | 1 |
| Borosky, SA; Clissold, DB; Ferkany, JW; Goode, S; Karbon, EW; Patch, RJ; Pontecorvo, MJ | 1 |
| Courtney, MJ; Nicholls, DG | 1 |
| Heikkila, RE; Riordan, DE; Sonsalla, PK | 1 |
| Butler, TW; Chenard, BL; Fox, CB; Koe, BK; Prochniak, MA; Ronau, RT; Schmidt, AW; Shalaby, IA | 1 |
| Costa, E; de Costa, BR; Di Chiro, G; Ferrarese, C; Fulham, MJ; Guidotti, A; Miletich, RS; Rice, KC | 1 |
| Legendre, P; Westbrook, GL | 1 |
| Millan, MJ | 1 |
| Drian, MJ; Kamenka, JM; Pirat, JL; Privat, A | 1 |
| Compton, RP; Hood, WF; Monahan, JB | 1 |
| Church, J; Lodge, D | 1 |
| Carter, CJ; Lloyd, KG; Scatton, B; Zivkovic, B | 1 |
| Chaki, S; Muramatsu, M; Otomo, S; Usuki-Ito, C | 1 |
| Boksa, P; Chaudieu, I; Mount, H; Quirion, R | 1 |
| Bigge, CF; Bobovski, TP; Brahce, LJ; Coughenour, LL; Drummond, JT; Hays, SJ; Johnson, G; Novak, PM; Rice, MJ | 1 |
| Meldrum, BS; Swan, JH | 1 |
| Johnson, BG; McQuaid, LA; Schoepp, DD; Smith, EC | 1 |
| Benavides, J; Gotti, B; MacKenzie, ET; Scatton, B | 1 |
| Allen, J; Langer, SZ; Schoemaker, H | 1 |
| Colpaert, FC; Koek, W; Woods, JH | 1 |
| France, CP; Winger, GD; Woods, JH | 1 |
| Amrick, CL; Bennett, DA; Bernard, PS; Hutchison, AJ; Liebman, JM; Wilson, DE | 1 |
| Angst, C; Bernard, PS; Blanchard, L; de Jesus, R; Hutchison, AJ; Jackson, RH; Murphy, DE; Schneider, J; Williams, M; Wilusz, EJ | 1 |
| Hillman, CC; Ornstein, PL; Salhoff, CR; Schoepp, DD | 1 |
| Miller, RJ; Reynolds, IJ | 1 |
| D'Angio, M; Scatton, B; Serrano, A | 1 |
| Jackson, A; Sanger, DJ | 2 |
| France, CP; Ornstein, P; Woods, JH | 1 |
| Amrick, CL; Bennett, DA; Bernard, PS | 1 |
| Chapman, AG; Hutchison, A; Lehmann, J; Meldrum, BS; Tsai, C; Wood, PL | 1 |
| Bertin, J; Carter, C; Dupont, R; Duverger, D; Frost, J; Gaudilliere, B; Gotti, B; MacKenzie, ET; Rousseau, J; Scatton, B | 1 |
| Arbilla, S; Benavides, J; Carter, C; Legendre, P; Lloyd, KG; MacKenzie, ET; Noel, F; Thuret, F; Vincent, JD; Zivkovic, B | 1 |
| Chavkin, C; Malouf, AT; Swearengen, E | 1 |
| Hurt, SD; Hutchison, AJ; Murphy, DE; Sills, MA; Williams, M | 1 |
| Loo, PS; Sills, MA; Williams, M | 1 |
| Hutchison, AJ; Lehmann, J; McPherson, SE; Mondadori, C; Murphy, DE; Schmutz, M; Sinton, CM; Steel, DJ; Tsai, C; Williams, M | 1 |
| Boast, CA; Etienne, PE; Gerhardt, SC; Lehmann, J; Liebman, JM; Pastor, G | 1 |
| Boast, CA; Pastor, G | 1 |
| Church, J; McLarnon, J; Sawyer, D | 1 |
| Desai, MA; Monn, JA; Schoepp, DD; Valli, MJ | 1 |
| Deben, SE; Gonzalez-Alvear, GM; Thompson-Montgomery, D; Werling, LL | 1 |
| Beart, PM; Frandsen, A; Schousboe, A | 1 |
| Bordner, J; Butler, TW; Chambers, LK; Chenard, BL; Collins, MA; De Costa, DL; Ducat, MF; Dumont, ML; Fox, CB; Mena, EE | 1 |
| al-Baracanji, KA; Bailey, SJ; Barone, FC; Benham, CD; Feuerstein, G; Harries, MH; Harrison, DC; Hunter, AJ; Lysko, PG; Price, WJ | 1 |
| Kadlec, O; Schuurkes, J; Seferna, I | 1 |
| Carter, C; Fage, D; Nankai, M | 1 |
| Kemp, JA; Ochu, E; Priestley, T | 1 |
| Calvet, MC; Kamenka, JM; Levallois, C; Petite, D | 1 |
| Williams, K | 1 |
| Carter, C; Fage, D; Nicolas, C | 1 |
| Balster, RL; Nicholson, KL; Sanger, DJ | 1 |
| Gonzalez-Alvear, GM; Werling, LL | 1 |
| Carter, C; Fage, D; Voltz, C | 1 |
| Jacobsen, P; Klockgether, T; Löschmann, PA; Turski, L | 1 |
| Van der Valk, JB; Vijverberg, HP | 1 |
| Gean, PW; Hsu, KS; Huang, CC | 1 |
| Chavez-Noriega, L; Crona, J; Daggett, LP; Deal, C; Ellis, SB; Hess, SD; Johnson, EC; Lu, CC; Urrutia, A; Veliçelebi, G | 1 |
| Klockgether, T; Löschmann, PA; Petersen, V; Steinbach, JP; Turski, L; Wüllner, U | 1 |
| Johnson, SW; Wu, YN | 1 |
| Carter, C; Fage, D; Klarica, M; Nankai, M | 1 |
| Basile, AS; Berlin, C; Huang, JM; Skolnick, P; Webster, D; Xie, C | 1 |
| Kirson, ED; Yaari, Y | 1 |
| Bergeron, R; Debonnel, G | 1 |
| Gisselmann, G; Gottmann, K; Hatt, H; Mehrle, A | 1 |
| Marcoli, M; Maura, G; Raiteri, M; Tortarolo, M | 1 |
| Ault, DT; Werling, LL | 1 |
| Semba, K; White, TD | 1 |
| Bao, J; Dawson, TM; Dawson, VL; Eliasson, MJ; Hurn, PD; Mandir, AS; Pieper, A; Sampei, K; Snyder, SH; Traystman, RJ; Wang, ZQ | 1 |
| Holahan, MR; Kelley, AE; Smith-Roe, SL | 1 |
| Akerman, KE; Courtney, MJ; Engblom, AC; Kukkonen, JP | 1 |
| Gonzalez, GM; Werling, LL | 1 |
| Blevins, T; Chandler, LJ; Mirshahi, T; Woodward, JJ | 1 |
| Camarasa, J; Camins, A; Escubedo, E; Gabriel, C; Pallàs, M; Sureda, FX | 1 |
| Chen, P; Hua, XY; Marsala, M; Nagy, I; Phillips, E; Polgar, E; Urban, L; Webb, M; Wollaston, L; Yaksh, TL | 1 |
| Ault, DT; Radeff, JM; Werling, LL | 1 |
| Daggett, LP; Deal, C; Hess, SD; Johnson, EC; Lu, CC; Veliçelebi, G | 1 |
| Stocca, G; Vicini, S | 1 |
| Kapin, MA; Opitz, T; Reyes, A; Reyes, M; Stanton, PK | 1 |
| Dichter, MA; Kendrick, SJ; Wilcox, KS | 1 |
| Blanchet, F; Gauchy, C; Glowinski, J; Kemel, ML; Perez, S; Soubrié, P | 2 |
| Kemp, JA; Kew, JN | 1 |
| Gruol, DL; Netzeband, JG; Qiu, Z; Sweeney, DD | 1 |
| Allgaier, C; Feuerstein, TJ; Illes, P; Müller, D; Scheibler, P | 1 |
| Abdrachmanova, G; Palecek, JI; Vlachová, V; Vyklick, L | 1 |
| Murali, SG; Sun, D | 1 |
| Carlsson, A; Carlsson, ML; Martin, P; Nilsson, M; Sorensen, SM; Waters, N; Waters, S | 1 |
| DeSantis, L; Kapin, MA; Nawy, S; Pang, IH; Wexler, EM | 1 |
| Chandler, ML; DeSantis, LM; Doshi, R; Kapin, MA; Scatton, B | 1 |
| Lickteig, RL; Lovinger, DM; Popp, RL | 1 |
| Arvigo, D; Bonfanti, A; Pittaluga, A; Raiteri, M | 1 |
| Klockgether, T; Löschmann, PA; Spieker, S | 1 |
| Sharif, NA; Xu, SX | 1 |
| Bauer, U; Göthert, M; Kathmann, M; Schlicker, E | 1 |
| Baubichon, D; Carpentier, P; Clarençon, D; Galonnier, M; Lallement, G; Peoc'h, M | 1 |
| d'Arbigny, P; Dukic, S; Hoizey, G; Lamiable, D; Millart, H; Vistelle, R | 1 |
| Brickley, SG; Cull-Candy, SG; Farrant, M; Misra, C | 1 |
| Butler, P; Chenard, BL; Frost White, W; Jaw-Tsai, SS; Menniti, FS; Pagnozzi, MJ | 1 |
| Beyreuther, K; Emilien, G; Maloteaux, JM; Masters, CL | 1 |
| Bunney, BS; Shi, WX; Zhang, XX | 1 |
| Barbanel, G; Kamenka, JM; Laplanche, L | 1 |
| d'Arbigny, P; Gaviria, M; Haton, H; Kamenka, J; Ohanna, F; Privat, A | 1 |
| Kolb, JE; Levine, ES | 1 |
| Fisher, M; Schaebitz, W | 1 |
| Chizh, BA; Englberger, W; Haase, G; Reissmüller, E; Scheede, M; Schlütz, H | 1 |
| Feligioni, M; Pattarini, R; Pittaluga, A; Raiteri, M | 1 |
| Shi, WX; Zhang, XX | 1 |
| Couture, S; Debonnel, G | 1 |
| Müller, T | 1 |
| Liu, X; Onaka, T; Yagi, K | 1 |
| Gibb, AJ; Green, GM | 1 |
| Glowinski, J; Godeheu, G; Kemel, ML; Pérez, S; Soubrié, P | 1 |
| Lei, S; McBain, CJ | 1 |
| Carpy, A; Elhallaoui, M; Laguerre, M; Ouazzani, FC | 1 |
| Azcoitia, I; Fernández-Ruiz, J; García-Segura, LM; Hansen, HH; Hansen, HS; Pons, S; Ramos, JA; Romero, J | 1 |
| Cebere, A; Cebers, G; Liljequist, S; Wägner, A | 1 |
| Chen, N; Li, B; Luo, T; Murphy, TH; Otsu, Y; Raymond, LA | 1 |
| Boros, A; Dezso, P; Kolok, S; Nagy, J; Szombathelyi, Z | 1 |
| Benchenane, K; Chuquet, J; MacKenzie, ET; Roussel, S; Toutain, J; Touzani, O | 1 |
| Breese, GR; Criswell, HE; Griffith, BL; Ming, Z | 1 |
| Dunn, RJ; Harvey-Girard, E | 1 |
| Jardemark, KE; Liang, X; Ninan, I; Wang, RY | 1 |
| Baimbridge, KG; Fernandes, HB; Krebs, C; Raymond, LA; Sheldon, C | 1 |
| Fang, M; Fisher, LL; Kovács, KJ; Larson, AA | 1 |
| Ogonowski, AA; Smith, JB | 1 |
| Brickley, SG; Cull-Candy, SG; Mishina, M; Misra, C; Mok, MH | 1 |
| Kuehl-Kovarik, MC; Magnusson, KR; Partin, KM | 1 |
| Beaujouan, JC; Glowinski, J; Jabourian, M; Kemel, ML; Pérez, S; Soubrié, P | 1 |
| Gallagher, JP; Liu, J; McKernan, MG; Russell, RT; Shinnick-Gallagher, P; Xie, J; Zinebi, F | 1 |
| Awe, SO; Harris, LC; Kulkarni, K; LeDay, AM; Ohia, SE; Opere, CA; Sharif, NA | 1 |
| Baronti, R; Meli, E; Moroni, F; Pangallo, M; Pellegrini-Giampietro, DE; Picca, R | 1 |
| André, VM; Cepeda, C; Flores-Hernández, J; Levine, MS; Lobo, MK; Mathern, GW; Nguyen, S; Starling, AJ; Vinters, HV | 1 |
| Hozumi, S; Kisara, K; Murata, A; Nakagawasai, O; Niijima, F; Tadano, T; Tan-No, K; Yamadera, F | 1 |
| Duguid, IC; Smart, TG | 1 |
| Mendiguren, A; Pineda, J | 1 |
| Sun, W; Wessinger, WD | 1 |
| Auberson, YP; Bashir, ZI; Brown, MW; Collingridge, GL; Johnson, BE; Massey, PV; Molnar, E; Moult, PR | 1 |
| Bermack, JE; Debonnel, G | 1 |
| Kolb, JE; Levine, ES; Trettel, J | 1 |
| Baraban, SC; Calcagnotto, ME | 1 |
| Bianchi, C; Della Corte, L; Fantin, M; Manzalini, M; Marti, M; Morari, M | 1 |
| Cadet, JL; Chen, J; Deng, X; Errico, S; Freed, WJ; Lee, CT | 1 |
| Kiyosue, K; Nakayama, K; Taguchi, T | 1 |
| Boon, A; Bridges, D; Deadwyler, SA; Grigorenko, E; Hampson, RE; McCloud, S; Zhuang, SY | 1 |
| Bregestovski, P; Mukhtarov, M; Ragozzino, D | 1 |
| Greenberg, DA; Jin, K; Kim, SH; Mao, XO; Won, SJ | 1 |
| Akasofu, S; Kimura, M; Kosasa, T; Ogura, H; Sawada, K | 2 |
| Clements, JM; Vanhoose, AM; Winder, DG | 1 |
| Mao, Y; Sun, X; Zang, S; Zhang, J | 1 |
| Nuwayhid, SJ; Werling, LL | 1 |
| Baudry, M; Zhou, M | 1 |
| Bonnert, TP; Fradley, RL; Heavens, RP; Hunt, V; Lawrence, JM; Macaulay, A; Rosahl, TW; Treacey, P; Usala, M; Wafford, KA; Whiting, PJ; Wingrove, PB | 1 |
| Bear, MF; Lu, W; Malenka, RC; Morishita, W; Nicoll, RA; Smith, GB | 1 |
| Yonehara, N; Yoshimura, M | 1 |
| Bannister, NJ; Bartlett, TE; Bashir, ZI; Bortolotto, ZA; Collett, VJ; Collingridge, GL; Dargan, SL; Fitzjohn, SM; Lodge, D; Massey, PV | 1 |
| Choi, HJ; Colwell, CS; Kim, YI | 1 |
| Cavalier, M; Cohen-Solal, C; Guiramand, J; Lanté, F; Vignes, M | 1 |
| Chen, Z; Dai, HB; Fan, YY; Fu, QL; Hu, WW; Luo, JH; Shen, Y; Wei, EQ | 1 |
| Budai, D; Khasabov, SG; Mantyh, PW; Simone, DA | 1 |
| Bergersen, LH; Bezzi, P; Bhaukaurally, K; Domercq, M; Gundersen, V; Jourdain, P; Matute, C; Santello, M; Tonello, F; Volterra, A | 1 |
| Coserea, I; Fuchs, EC; Köhr, G; Monyer, H; Pawlak, V; Seeburg, PH; von Engelhardt, J | 1 |
| Igarashi, K; Kashiwagi, K; Kizawa, Y; Kusama, T; Kusama-Eguchi, K; Masuko, T; Miyake, M; Nagaoka, H; Nemoto, Y | 1 |
| Ando, K; Fujita, I; Hattori, K; Hirota, M; Hizue, M; Kawai, M; Kawamura, M; Matsumoto, Y; Mizutani, M; Nakamura, H; Ohta, A; Sakurada, I; Sudo, M; Takashima, T; Watanabe, S | 1 |
| Chandler, LJ; Luong, NT; Mulholland, PJ; Woodward, JJ | 1 |
| Downey, D | 1 |
| Chang, HM; Chang, SY; Chen, GD; Chiu, CH; Chou, D; Lai, CY; Lee, SD; Lin, TB; Peng, HY; Tung, KC | 1 |
| Ogata, M; Oh-Nishi, A; Saji, M; Satoh, SZ; Suzuki, N | 1 |
| Beazely, MA; Chen, X; Li, H; Lim, A; Macdonald, JF; Sidhu, B; Trepanier, C | 1 |
| Gibson, C; Hartman, GD; Jacobson, MA; Kinney, GG; Leister, WH; Lemaire, W; Lindsley, CW; Ma, BK; O'Brien, J; Pettibone, DJ; Polsky-Fisher, SL; Smith, S; Sur, C; Tiller, PR; Williams, DL; Wisnoski, DD; Wolkenberg, SE; Zhao, Z | 1 |
| Dehpour, AR; Ghasemi, M; Raza, M | 1 |
| Castellino, FJ; Geiger, JH; Liang, Z; Prorok, M; Sheng, Z | 1 |
| El Manira, A; Grillner, S; Hill, RH; Thörn Pérez, C | 1 |
| Chen, JF; Chiodi, V; Domenici, MR; Ferrante, A; Frank, C; Ledent, C; Martire, A; Pepponi, R; Popoli, P; Tebano, MT | 1 |
| Bhat, M; Bowen, WD; Cheng, J; Liu, Q | 1 |
| Berry, JN; Butler, TR; Littleton, JM; Mulholland, PJ; Pauly, JR; Prendergast, MA; Self, RL; Sharrett-Field, LJ; Smith, KJ | 1 |
| Armand, V; Arrang, JM; Bayard, C; Burban, A; Faucard, R; Vorobjev, V | 1 |
| Bauchet, L; Gaviria, M; Haton, H; Kouyoumdjian, P; Lonjon, N; Perrin, FE; Prieto, M; Privat, A | 1 |
| Bose, R; Parkinson, FE; Zamzow, CR | 1 |
| Büttner, T; Csoti, I; Kassubek, J; Reichmann, H; Riederer, P; Schulz, JB; Wüllner, U | 1 |
| Demb, JB; Manookin, MB; Stafford, BK; Weick, M | 1 |
| Bevins, RA; Murray, JE; Polewan, RJ; Walker, AW | 1 |
| Cunha, RA; Musante, V; Pittaluga, A; Raiteri, M; Summa, M | 1 |
| Ashby, MC; Isaac, JT; Matta, JA; Roche, KW; Sanz-Clemente, A | 1 |
| Cao, J; Hu, XD; Li, S; Liu, YN; Shi, L; Suo, ZW; Yang, HB; Yang, X | 1 |
| Cirrito, JR; Goebel, WD; Holtzman, DM; Restivo, JL; Verges, DK | 1 |
| Höfner, G; Müller, A; Parsons, CG; Renukappa-Gutke, T; Wanner, KT | 1 |
| Biber, B; Björklund, U; Hansson, E; Lundborg, C; Westerlund, A | 1 |
| Ali, C; Docagne, F; Fernandez-Ruiz, J; Ramos, JA; Roussel, BD; Rubio, M; Villain, H; Vivien, D | 1 |
| Helmstetter, FJ; Jarome, TJ; Kwapis, JL; Werner, CT | 1 |
| Dehmel, M; Fischer, C; Henle, F; Leemhuis, J; Meyer, DK | 1 |
| El Manira, A; Kyriakatos, A; Song, J | 1 |
| Berch, AM; Della-Pace, ID; Fighera, MR; Furian, AF; Oliveira, MS; Rambo, LM; Ribeiro, LR; Royes, LF; Schramm, VG; Silva, LF; Stamm, DN | 1 |
| Brittain, JM; Brittain, MK; Brustovetsky, N; Brustovetsky, T; Cummins, TR; Khanna, R | 1 |
| Abily-Donva, L; Dureuil, B; Gonzalez, BJ; Jégou, S; Tourrel, F | 1 |
| Fujiwara, H; Inada, C; Matsumoto, K; Miyata, T; Thi Le, X; Tsuneyama, K | 1 |
| Bechmann, I; Dehghani, F; Ehrlich, A; Geisslinger, G; Hobusch, C; Kallendrusch, S; Koch, M; Nowicki, M; Ziebell, S | 1 |
| Brabant, C; Charlier, Y; Tirelli, E | 1 |
| Barré, L; Becerril-Ortega, J; Buisson, A; Colloc'h, N; Dhilly, M; MacKenzie, ET; Nicole, O; Perrio, C | 1 |
| Morales, M; Spear, LP; Varlinskaya, EI | 1 |
| Arnsten, AF; Jin, LE; Paspalas, CD; Picciotto, MR; Wang, M; Yang, Y | 1 |
| Nasehi, M; Oryan, S; Rasekhi, K; Zarrindast, MR | 1 |
| Chen, ZQ; Jiang, ZL; Li, X; Sun, L; Xu, LH; Yang, Y; Zhang, YF; Zhang, YY | 1 |
| Aguiar, DC; Hott, SC; Moreira, FA; Resstel, LB; Viana, TG | 1 |
| Bilgin, R; Kilinc, M; Mert, T; Oksuz, H; Senoglu, N; Tugtag, B | 1 |
| Amin-Yavari, S; Ebrahimi-Ghiri, M; Nasehi, M; Torabi-Nami, M; Zarrindast, MR | 1 |
| Galvin, C; Lee, FS; Ninan, I | 1 |
| Antic, SD; Oikonomou, KD; Rich, MT; Short, SM; Singh, MB | 1 |
| Smothers, CT; Szumlinski, KK; Woodward, JJ; Worley, PF | 1 |
| Aguiar, DC; Almeida-Santos, AF; Gobira, PH; Guimaraes, FS; Moreira, FA | 1 |
| Cichon, J; Huang, L; Ninan, I; Yang, G | 1 |
| Cheng, B; Huang, Y; Li, D; Liu, G; Shen, W; Su, J; Zhang, YX; Zhou, WX | 1 |
| Asahara, H; Fukaya, M; Hagiwara, M; Kobayashi, S; Komano-Inoue, S; Manabe, H; Manabe, T; Mizuguchi, M; Murakami, T; Ogonuki, N; Ogura, A; Okuda, K; Sakagami, H; Sato, T; Tanaka, T; Ueno, H; Watanabe, A; Yamaguchi, M | 1 |
| Chen, L; Huang, M; Jiang, B; Li, S; Li, Y; Wang, L; Wang, X; Yang, Y; Zhang, X | 1 |
| Chang, JW; Jung, HH; Koh, CS; Kong, C; Lee, J; Shin, J; Yoon, MS | 1 |
| Bernal-Chico, A; Brown, JM; Cipriani, R; Cravatt, BF; Hsu, KL; Manterola, A; Mato, S; Matute, C; Moreno-Rodríguez, M; Pérez-Samartín, A; Rodríguez-Puertas, R; Ruiz, A | 1 |
| Aguiar, DC; Bastos, JR; Coimbra, CC; Costa, RB; Hott, SC; Mansur, FS; Moreira, FA; Resstel, LB; Viana, TG | 1 |
| Coimbra, NC; de Fátima Dos Santos Sampaio, M; de Souza Crippa, JA; Dos Anjos-Garcia, T; Falconi-Sobrinho, LL; Khan, AU; Menescal-de-Oliveira, L | 1 |
| da Cunha, JM; Godoi, MM; Junior, HZ; Zanoveli, JM | 1 |
| Dahlén, A; Guo, S; Melgoza, A; Wagle, M; Zarei, M | 1 |
| Bedeschi, M; Collina, S; Denora, N; Dondio, G; Franchini, S; Linciano, P; Marino, N; Marsala, A; Miserocchi, G; Peviani, M; Rossi, D; Rossino, G; Sorbi, C; Tesei, A | 1 |
6 review(s) available for n-methylaspartate and piperidines
| Article | Year |
|---|---|
Review of the value of gacyclidine (GK-11) as adjuvant medication to conventional treatments of organophosphate poisoning: primate experiments mimicking various scenarios of military or terrorist attack by soman.
Topics: Animals; Cyclohexanes; Cyclohexenes; Excitatory Amino Acid Antagonists; Haplorhini; Humans; N-Methylaspartate; Organophosphorus Compounds; Piperidines; Receptors, N-Methyl-D-Aspartate; Seizures; Soman; Time Factors | 1999 |
Prospects for pharmacological intervention in Alzheimer disease.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspartic Acid Endopeptidases; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Endopeptidases; Hippocampus; Humans; Indans; N-Methylaspartate; Nerve Growth Factors; Nicotine; Piperidines; Tacrine | 2000 |
An overview of acute stroke therapy: past, present, and future.
Topics: Acute Disease; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antibodies; Brain Ischemia; Calcium Channel Blockers; Cardiovascular Agents; Cell Adhesion Molecules; Clinical Trials as Topic; Cytidine Diphosphate Choline; Cytokines; Drug Therapy, Combination; Fibrinolytic Agents; Free Radical Scavengers; gamma-Aminobutyric Acid; Growth Substances; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; N-Methylaspartate; Neuroprotective Agents; Nootropic Agents; Piperidines; Stroke; Thiazoles; Thrombolytic Therapy | 2000 |
Non-dopaminergic drug treatment of Parkinson's disease.
Topics: Adenosine; Adrenergic alpha-Antagonists; Body Weight; Cholinergic Antagonists; Homocysteine; Humans; Levodopa; Methionine; N-Methylaspartate; Parkinson Disease; Piperidines; Serotonin Receptor Agonists | 2001 |
Pharmacologic management of Alzheimer disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Galantamine; Humans; Indans; Memantine; N-Methylaspartate; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine | 2008 |
[On the role of MAO B inhibitors and NMDA antagonists in the therapy of Parkinson's disease].
Topics: Amantadine; Excitatory Amino Acid Antagonists; Humans; Indans; Memantine; Monoamine Oxidase; Monoamine Oxidase Inhibitors; N-Methylaspartate; Parkinson Disease; Piperidines; Selegiline | 2010 |
2 trial(s) available for n-methylaspartate and piperidines
| Article | Year |
|---|---|
The NMDA antagonist budipine can alleviate levodopa-induced motor fluctuations.
Topics: Adult; Aged; Antiparkinson Agents; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Middle Aged; N-Methylaspartate; Parkinson Disease; Pilot Projects; Piperidines; Severity of Illness Index | 1999 |
NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue.
Topics: Adolescent; Cells, Cultured; Cerebral Cortex; Child; Child, Preschool; Epilepsy; Humans; Infant; Magnesium; Membrane Potentials; N-Methylaspartate; Piperidines; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Reference Values | 2004 |
222 other study(ies) available for n-methylaspartate and piperidines
| Article | Year |
|---|---|
Developmental differences in antagonism of NMDA toxicity by the polyamine site antagonist ifenprodil.
Topics: Amino Acids; Animals; Biogenic Polyamines; Chick Embryo; Dizocilpine Maleate; Kynurenic Acid; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, Glutamate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Retina | 1992 |
Neuroprotective effects of the N-methyl-D-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture.
Topics: Animals; Cells, Cultured; Culture Media; Dizocilpine Maleate; Drug Antagonism; Glutamates; Glutamic Acid; Hippocampus; L-Lactate Dehydrogenase; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1992 |
The putative polyamine antagonists ifenprodil and SL 82.0715 enhance dopamine efflux from rat striatal slices independent of NMDA receptor activation.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Cocaine; Dopamine; Male; N-Methylaspartate; Norepinephrine; Piperidines; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
The neuroprotective properties of ifenprodil, a novel NMDA receptor antagonist, in neuronal cell culture toxicity studies.
Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cyanates; Dizocilpine Maleate; Glutamates; Glutamic Acid; Kainic Acid; Mice; N-Methylaspartate; Neurons; Piperidines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate | 1992 |
Biphasic dose-dependent effects of dopamine and involvement of dopamine autoreceptors on intra-ocular pressure in the rabbit.
Topics: Animals; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Intraocular Pressure; Male; N-Methylaspartate; Ocular Hypertension; Piperidines; Rabbits; Receptors, Dopamine; Thiothixene | 1992 |
Pre-synaptic dopaminergic control mechanisms for CCK-8 like immunoreactivity in the rat medial frontal cortex.
Topics: Animals; Apomorphine; Behavior, Animal; Cholecystokinin; Dopamine; Dopamine Agents; In Vitro Techniques; Male; Microinjections; N-Methylaspartate; Nerve Degeneration; Neurons; Piperidines; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Dopamine | 1992 |
Modulation by sigma ligands of N-methyl-D-aspartate-induced [3H]noradrenaline release in the rat hippocampus: G-protein dependency.
Topics: Animals; Calcium; Cinnamates; Cyclopropanes; Dose-Response Relationship, Drug; Ethylmaleimide; GTP-Binding Proteins; Guanidines; Haloperidol; Hippocampus; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Norepinephrine; Pertussis Toxin; Piperidines; Rats; Rats, Inbred Strains; Spiperone; Tritium; Virulence Factors, Bordetella | 1992 |
SL 82.0715, an NMDA antagonist acting at the polyamine site, does not induce neurotoxic effects on rat cortical neurons.
Topics: Animals; Biogenic Polyamines; Cerebral Cortex; Cytoplasm; Dizocilpine Maleate; In Vitro Techniques; Male; Microscopy, Electron; N-Methylaspartate; Neurons; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Vacuoles | 1992 |
Possible cerebroprotective and in vivo NMDA antagonist activities of sigma agents.
Topics: Animals; Anticonvulsants; Brain Diseases; Electroshock; Haloperidol; Hypoxia; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Nimodipine; Piperidines; Postural Balance; Pyrimidines; Receptors, Opioid; Receptors, sigma; Seizures | 1991 |
Metabotropic receptor-mediated regulation of cytoplasmic free calcium in cultured cerebellar granule cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Carbachol; Cells, Cultured; Cerebellum; Cycloleucine; Cytoplasm; Ibotenic Acid; Kinetics; N-Methylaspartate; Neurotoxins; Piperidines; Quisqualic Acid; Receptors, Neurotransmitter | 1991 |
Competitive and noncompetitive antagonists at N-methyl-D-aspartate receptors protect against methamphetamine-induced dopaminergic damage in mice.
Topics: Amino Acids; Animals; Corpus Striatum; Dizocilpine Maleate; Male; Methamphetamine; Mice; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Tyrosine 3-Monooxygenase | 1991 |
Separation of alpha 1 adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds.
Topics: Adrenergic alpha-Antagonists; Animals; Molecular Structure; N-Methylaspartate; Piperidines; Rats; Receptors, Adrenergic, alpha; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Structure-Activity Relationship | 1991 |
In vivo study of NMDA-sensitive glutamate receptor by fluorothienylcyclohexylpiperidine [correction of fluorothienylcycloexylpiperidine], a possible ligand for positron emission tomography.
Topics: Animals; Binding Sites; Brain; Cerebral Cortex; Corpus Striatum; Glutamates; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Injections, Intravenous; Macaca mulatta; Male; Mice; N-Methylaspartate; Piperidines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Membranes; Tomography, Emission-Computed | 1991 |
Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Glycine; Ibotenic Acid; Ion Channels; N-Methylaspartate; Piperidines; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Vasodilator Agents | 1991 |
Antagonists at the NMDA recognition site and blockers of the associated ion channel induce spontaneous tail-flicks in the rat.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ion Channels; Ketamine; Male; N-Methylaspartate; Organophosphorus Compounds; Phencyclidine; Pipecolic Acids; Piperazines; Piperidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Non-competitive antagonists of N-methyl-D-aspartate prevent spontaneous neuronal death in primary cultures of embryonic rat cortex.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclohexanes; Cyclohexenes; Dizocilpine Maleate; Embryo, Mammalian; Female; N-Methylaspartate; Neurons; Phencyclidine; Piperidines; Pregnancy; Rats; Rats, Inbred Strains | 1991 |
N-methyl-D-aspartate recognition site ligands modulate activity at the coupled glycine recognition site.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Glutamates; Glutamic Acid; Glycine; Ligands; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines | 1990 |
Failure of sigma-receptor ligands to reduce the excitatory actions of N-methyl-DL-aspartate on rat spinal neurons in-vivo.
Topics: Animals; Aspartic Acid; Haloperidol; In Vitro Techniques; Kainic Acid; Ligands; N-Methylaspartate; Neurons; Oxadiazoles; Piperidines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord; Stereoisomerism | 1990 |
Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex.
Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Brain; Cells, Cultured; Drug Interactions; Female; Glycine; Male; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine; Spermine; Spinal Cord | 1990 |
Differentiation of the active site of minaprine from that of phencyclidine in rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Binding Sites; Hippocampus; Ketamine; Male; Membranes; N-Methylaspartate; Phencyclidine; Piperazines; Piperidines; Potassium Channels; Pyridazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1990 |
Action of the anti-ischemic agent ifenprodil on N-methyl-D-aspartate and kainate-mediated excitotoxicity.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Antagonists; Animals; Chick Embryo; gamma-Aminobutyric Acid; Kainic Acid; N-Methylaspartate; Neurons; Piperidines; Quinoxalines; Retina | 1990 |
Phencyclidine and related compounds evoked [3H]dopamine release from rat mesencephalic cell cultures by a mechanism independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Binding Sites; Cells, Cultured; Dioxolanes; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Guanidines; Mesencephalon; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Phencyclidine; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Sigma Factor; Tritium | 1990 |
New and versatile approaches to the synthesis of CPP-related competitive NMDA antagonists. Preliminary structure-activity relationships and pharmacological evaluation.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Chemical Phenomena; Chemistry, Physical; In Vitro Techniques; N-Methylaspartate; Piperazines; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Synaptic Membranes | 1990 |
Protection by NMDA antagonists against selective cell loss following transient ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Neurons; Pipecolic Acids; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Brain; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Stereoisomerism | 1990 |
The pharmacotherapy of focal cortical ischaemia in the mouse.
Topics: Animals; Calcium Channel Blockers; Cell Survival; Cyclandelate; Ischemic Attack, Transient; Male; Mice; Molecular Structure; N-Methylaspartate; Piperidines; Platelet Activating Factor; Receptors, GABA-A; Receptors, Opioid; Receptors, sigma; Vincamine | 1990 |
Binding of [3H]ifenprodil, a novel NMDA antagonist, to a polyamine-sensitive site in the rat cerebral cortex.
Topics: Animals; Aspartic Acid; Biogenic Polyamines; Cerebral Cortex; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Piperidines; Rats; Rats, Inbred Strains | 1990 |
N-methyl-D-aspartate antagonism and phencyclidine-like activity: a drug discrimination analysis.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Injections, Intraperitoneal; Kainic Acid; Male; Mice; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains | 1990 |
Analgesic, anesthetic, and respiratory effects of the competitive N-methyl-D-aspartate (NMDA) antagonist CGS 19755 in rhesus monkeys.
Topics: Analgesics; Anesthetics; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Ketamine; Macaca mulatta; N-Methylaspartate; Pipecolic Acids; Piperidines; Reaction Time; Respiration; Video Recording | 1990 |
Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-methyl-D-aspartate receptors.
Topics: Animals; Anticonvulsants; Aspartic Acid; Conflict, Psychological; Discrimination Learning; Male; Mice; Mice, Inbred DBA; Motor Activity; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
4-(Phosphonoalkyl)- and 4-(phosphonoalkenyl)-2-piperidinecarboxylic acids: synthesis, activity at N-methyl-D-aspartic acid receptors, and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Aspartic Acid; Chemical Phenomena; Chemistry; Male; Mice; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship | 1989 |
CGS-19755 and MK-801 selectively prevent rat striatal cholinergic and gabaergic neuronal degeneration induced by N-methyl-D-aspartate and ibotenate in vivo.
Topics: Animals; Aspartic Acid; Choline O-Acetyltransferase; Cholinergic Fibers; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Ibotenic Acid; Male; N-Methylaspartate; Nerve Degeneration; Oxazoles; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines.
Topics: Acetamides; Animals; Aspartic Acid; Brain; Calcium; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glycine; In Vitro Techniques; Ketamine; Kinetics; N-Methylaspartate; Phencyclidine; Piperidines; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
NMDA antagonists block restraint-induced increase in extracellular DOPAC in rat nucleus accumbens.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Carbolines; Convulsants; Diazepam; Male; N-Methylaspartate; Nucleus Accumbens; Phenylacetates; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Restraint, Physical; Riluzole; Septal Nuclei; Thiazoles | 1989 |
Conditioned taste aversions induced by phencyclidine and other antagonists of N-methyl-D-aspartate.
Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Avoidance Learning; Conditioning, Operant; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Taste | 1989 |
Effects of phencyclidine and other N-methyl-D-aspartate antagonists on the schedule-controlled behavior of rats.
Topics: Animals; Aspartic Acid; Conditioning, Psychological; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Piperazines; Piperidines; Punishment; Rats; Rats, Inbred Strains; Reinforcement Schedule; Stereoisomerism | 1989 |
The competitive N-methyl-D-aspartate (NMDA) antagonist CGS 19755 attenuates the rate-decreasing effects of NMDA in rhesus monkeys without producing ketamine-like discriminative stimulus effects.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Ketamine; Macaca mulatta; Male; N-Methylaspartate; Pipecolic Acids; Piperidines | 1989 |
A comparison of PCP-like compounds for NMDA antagonism in two in vivo models.
Topics: Animals; Aspartic Acid; Behavior, Animal; Dioxolanes; Dioxoles; Ketamine; Male; Mice; Motor Activity; N-Methylaspartate; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1988 |
CGS 19755 is a potent and competitive antagonist at NMDA-type receptors.
Topics: Acetylcholine; Animals; Aspartic Acid; Binding, Competitive; Blood-Brain Barrier; Cerebellum; Cyclic GMP; Harmaline; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1988 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cats; Female; Male; Models, Cardiovascular; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Vasoconstriction | 1988 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cells, Cultured; Cerebellum; Corpus Striatum; Cyclic GMP; Dopamine; Harmaline; In Vitro Techniques; Mice; N-Methylaspartate; Phencyclidine; Piperazines; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1988 |
Comparison of the actions of phencyclidine and sigma ligands on CA1 hippocampal pyramidal neurons in the rat.
Topics: Action Potentials; Animals; Aspartic Acid; Guanidines; Hippocampus; Male; N-Methylaspartate; Neurons; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1988 |
Characterization of the binding of [3H]-CGS 19755: a novel N-methyl-D-aspartate antagonist with nanomolar affinity in rat brain.
Topics: Animals; Aspartic Acid; Brain; Intracellular Membranes; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
The NMDA antagonists, CPP and CGS 19755, lack affinity for central benzodiazepine receptors.
Topics: Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Brain; Flunitrazepam; In Vitro Techniques; N-Methylaspartate; Pipecolic Acids; Piperazines; Piperidines; Rats; Receptors, GABA-A | 1988 |
CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.
Topics: Acetylcholine; Aconitine; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Binding, Competitive; Darkness; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Structure-Activity Relationship; Tetrodotoxin | 1988 |
The N-methyl-D-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils.
Topics: Animals; Aspartic Acid; Brain; Female; Gerbillinae; Hippocampus; Ischemic Attack, Transient; Motor Activity; N-Methylaspartate; Neurons; Pipecolic Acids; Piperazines; Piperidines | 1988 |
Characterization of motor activity patterns induced by N-methyl-D-aspartate antagonists in gerbils.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Electronic Data Processing; Female; Gerbillinae; Ketamine; Motor Activity; N-Methylaspartate; Pipecolic Acids; Piperazines; Piperidines; Time Factors | 1987 |
The actions of L-687,384, a sigma receptor ligand, on NMDA-induced currents in cultured rat hippocampal pyramidal neurons.
Topics: Animals; Cells, Cultured; Cytophotometry; Fura-2; Hippocampus; Ion Channels; N-Methylaspartate; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 1994 |
1-BCP, a memory-enhancing agent, selectively potentiates AMPA-induced [3H]norepinephrine release in rat hippocampal slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Dioxoles; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Memory; N-Methylaspartate; Norepinephrine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 1995 |
Functional and binding properties of sigma receptors in rat cerebellum.
Topics: Animals; Binding, Competitive; Cerebellum; Cyclohexylamines; Female; Glycine; Haloperidol; Male; N-Methylaspartate; Norepinephrine; Pentazocine; Piperidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Stereoisomerism | 1995 |
Blockade by polyamine NMDA antagonists related to ifenprodil of NMDA-induced synthesis of cyclic GMP, increases in calcium and cytotoxicity in cultured neurones.
Topics: Animals; Calcium; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Female; Mice; N-Methylaspartate; Neurons; Piperidines; Propanolamines; Receptors, N-Methyl-D-Aspartate | 1995 |
(1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses.
Topics: Animals; Cell Death; Cells, Cultured; Genes, fos; Hippocampus; Male; Mice; N-Methylaspartate; Nerve Degeneration; Piperidines; Rats; Structure-Activity Relationship | 1995 |
SB 201823-A antagonizes calcium currents in central neurons and reduces the effects of focal ischemia in rats and mice.
Topics: Animals; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebellum; Cerebral Infarction; Disease Models, Animal; Glycine; Hippocampus; Ischemic Attack, Transient; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Piperidines; Potassium Chloride; Rats; Rats, Inbred F344; Rats, Inbred Strains; Rats, Sprague-Dawley | 1995 |
The topographical basis and frequency-dependence in the effect of different compounds on neurogenic contractions of the guinea-pig ileum.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Cisapride; Electric Stimulation; Electrophysiology; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mollusk Venoms; Muscle Contraction; N-Methylaspartate; Neuropeptide Y; omega-Conotoxin GVIA; Peptides; Piperidines; Potassium; Sodium; Synapses | 1993 |
NMDA receptor subtype selectivity: eliprodil, polyamine spider toxins, dextromethorphan, and desipramine selectively block NMDA-evoked striatal acetylcholine but not spermidine release.
Topics: Acetylcholine; Animals; Corpus Striatum; Desipramine; Dextromethorphan; Indoleacetic Acids; N-Methylaspartate; Phenols; Phenylacetates; Piperidines; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spider Venoms | 1995 |
Subtypes of NMDA receptor in neurones cultured from rat brain.
Topics: Animals; Brain; Brain Chemistry; Cells, Cultured; Glycine; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pipecolic Acids; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
Neuroprotective effect of N-methyl-D-aspartate non-competitive antagonists (arylcyclohexylamine derivatives) on human cultured spinal cord cells.
Topics: Cells, Cultured; Cyclohexanes; Cyclohexenes; Cyclohexylamines; gamma-Aminobutyric Acid; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; N-Methylaspartate; Neurites; Neuroglia; Neurons; Piperidines; Spinal Cord; Stereoisomerism | 1994 |
Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Electrophysiology; Glycine; Kinetics; Membrane Potentials; N-Methylaspartate; Oocytes; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA, Messenger; Xenopus laevis | 1993 |
NMDA receptors with different sensitivities to magnesium and ifenprodil control the release of [14C]acetylcholine and [3H]spermidine from rat striatal slices in vitro.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Aminoquinolines; Animals; Carbon Radioisotopes; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Magnesium; Magnesium Chloride; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 1994 |
Evaluation of the reinforcing effects of eliprodil in rhesus monkeys and its discriminative stimulus effects in rats.
Topics: Animals; Appetitive Behavior; Brain; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Macaca mulatta; Male; Motivation; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Wistar; Reinforcement Schedule; Self Administration | 1994 |
Regulation of [3H]dopamine release from rat striatal slices by sigma receptor ligands.
Topics: Animals; Atropine; Corpus Striatum; Dopamine; Flavonoids; In Vitro Techniques; N-Methylaspartate; Naloxone; Pentazocine; Phenazocine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma | 1994 |
Synergism between the NMDA receptor antagonistic effects of ifenprodil and the glycine antagonist, 7-chlorokynurenate, in vivo.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Synergism; Glycine; Injections; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1994 |
The antiparkinsonian agent budipine is an N-methyl-D-aspartate antagonist.
Topics: Amino Acids; Anesthesia; Animals; Antiparkinson Agents; Binding, Competitive; Brain Chemistry; H-Reflex; In Vitro Techniques; Male; Mice; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Reflex; Reflex, Monosynaptic; Seizures; Spinal Cord | 1993 |
Chronic sabeluzole treatment of cultured rat cerebellar granule cells reduces N-methyl-D-aspartate-induced inward current.
Topics: Animals; Cells, Cultured; Cerebellum; Membrane Potentials; N-Methylaspartate; Piperidines; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Thiazoles | 1993 |
Muscarinic depression of excitatory synaptic transmission mediated by the presynaptic M3 receptors in the rat neostriatum.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbachol; Depression, Chemical; Electric Stimulation; Evoked Potentials; In Vitro Techniques; N-Methylaspartate; Neostriatum; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Presynaptic; Synaptic Transmission | 1995 |
Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors.
Topics: Animals; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; N-Methylaspartate; Piperidines; Receptors, N-Methyl-D-Aspartate; Xenopus | 1996 |
Effects of the antiparkinsonian drug budipine on central neurotransmitter systems.
Topics: Animals; Antiparkinson Agents; Biperiden; Central Nervous System; Dopamine; Excitatory Amino Acid Antagonists; Male; Mice; Microdialysis; Muscarinic Antagonists; N-Methylaspartate; Neostriatum; Neurotransmitter Agents; Oxidopamine; Piperazines; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Rotation; Seizures; Stereotyped Behavior; Sympatholytics | 1996 |
Pharmacological characterization of inward current evoked by N-methyl-D-aspartate in dopamine neurons in the rat brain slice.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; In Vitro Techniques; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Sodium; Spermine; Substantia Nigra; Ventral Tegmental Area | 1996 |
Evidence for native NMDA receptor subtype pharmacology as revealed by differential effects on the NMDA-evoked release of striatal neuromodulators: eliprodil, ifenprodil and other native NMDA receptor subtype selective compounds.
Topics: Animals; Calcium Channel Blockers; Corpus Striatum; Dantrolene; Excitatory Amino Acid Antagonists; In Vitro Techniques; N-Methylaspartate; Neurotransmitter Agents; Piperidines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Tetrodotoxin | 1996 |
N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss.
Topics: Animals; Anti-Bacterial Agents; Cochlea; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Guinea Pigs; Hair Cells, Auditory; Hearing Loss; Hearing Tests; Kanamycin; Male; N-Methylaspartate; Neomycin; Piperidines; Prosencephalon; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Synaptic NMDA receptors in developing mouse hippocampal neurones: functional properties and sensitivity to ifenprodil.
Topics: Age Factors; Animals; Dendrites; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Ion Channel Gating; Kinetics; Magnesium; Mice; Mice, Inbred Strains; N-Methylaspartate; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Synapses | 1996 |
Effects of low and high doses of selective sigma ligands: further evidence suggesting the existence of different subtypes of sigma receptors.
Topics: Animals; Cinnamates; Cyclohexylamines; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Excitatory Amino Acid Agonists; Guanidines; Hippocampus; Ligands; Male; N-Methylaspartate; Neurons; Pentazocine; Piperidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, sigma | 1997 |
Presynaptic control of subunit composition of NMDA receptors mediating synaptic plasticity.
Topics: Animals; Bicuculline; Cells, Cultured; Coculture Techniques; Embryo, Mammalian; Evoked Potentials; Excitatory Amino Acid Antagonists; Hippocampus; Kinetics; Macromolecular Substances; Magnesium; N-Methylaspartate; Neuronal Plasticity; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Polymerase Chain Reaction; Presynaptic Terminals; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Synapses | 1997 |
Serotonin inhibition of the NMDA receptor/nitric oxide/cyclic GMP pathway in rat cerebellum: involvement of 5-hydroxytryptamine2C receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebellum; Cyclic GMP; Excitatory Amino Acid Agonists; Fluorobenzenes; Indoles; Male; N-Methylaspartate; Nitric Oxide; Organ Culture Techniques; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Urea; Yohimbine | 1997 |
Differential modulation of NMDA-stimulated [3H]dopamine release from rat striatum by neuropeptide Y and sigma receptor ligands.
Topics: Analgesics; Animals; Corpus Striatum; Cyclohexylamines; Dopamine; Dose-Response Relationship, Drug; Ethylamines; Haloperidol; Male; N-Methylaspartate; Neuropeptide Y; Piperidines; Pyrrolidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma | 1997 |
M3 muscarinic receptor-mediated enhancement of NMDA-evoked adenosine release in rat cortical slices in vitro.
Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Atropine; Carbachol; Cerebral Cortex; Diamines; Drug Synergism; In Vitro Techniques; Kinetics; Magnesium; Male; Muscarinic Agonists; Muscarinic Antagonists; N-Methylaspartate; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M3; Receptors, Muscarinic | 1997 |
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.
Topics: Adenosine Triphosphate; Animals; Benzamides; Brain; Cells, Cultured; Cerebral Cortex; Cerebrovascular Circulation; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Hemodynamics; Immunity, Innate; Ischemic Attack, Transient; Isoquinolines; Mice; Mice, Knockout; N-Methylaspartate; NAD; Neurons; Neurotoxins; Nitrates; Nitric Oxide; Piperidines; Poly(ADP-ribose) Polymerases | 1997 |
Response-reinforcement learning is dependent on N-methyl-D-aspartate receptor activation in the nucleus accumbens core.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidepressive Agents; Appetitive Behavior; Behavior, Animal; Conditioning, Operant; Dopamine; Excitatory Amino Acid Antagonists; Feeding Behavior; Food Deprivation; Locomotion; Male; N-Methylaspartate; Nucleus Accumbens; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reinforcement, Psychology | 1997 |
Ethanol specifically inhibits NMDA receptors with affinity for ifenprodil in the low micromolar range in cultured cerebellar granule cells.
Topics: Animals; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Glycine; Kinetics; N-Methylaspartate; Neurons; Piperidines; Potassium Chloride; Rats; Receptors, N-Methyl-D-Aspartate | 1997 |
Release of [3H]dopamine from guinea pig striatal slices is modulated by sigma1 receptor agonists.
Topics: Animals; Corpus Striatum; Cyclohexylamines; Dizocilpine Maleate; Dopamine; Ethylamines; Guinea Pigs; In Vitro Techniques; Male; N-Methylaspartate; Naloxone; Pentazocine; Piperidines; Pyrrolidines; Receptors, sigma; Serotonin Antagonists; Serotonin Receptor Agonists; Sigma-1 Receptor | 1997 |
Effects of acute and chronic ethanol exposure on heteromeric N-methyl-D-aspartate receptors expressed in HEK 293 cells.
Topics: Animals; Calcium; Cell Line; Drug Combinations; Electric Conductivity; Ethanol; Excitatory Amino Acid Antagonists; Glycine; Humans; Intracellular Membranes; N-Methylaspartate; Oocytes; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Time Factors; Transfection | 1997 |
Modulation of neuronal mitochondrial membrane potential by the NMDA receptor: role of arachidonic acid.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Local; Animals; Arachidonic Acid; Biomarkers; Cells, Cultured; Cerebellum; Dibucaine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flow Cytometry; Fluorescent Dyes; Glycine; Intracellular Membranes; Kynurenic Acid; Membrane Potentials; Mitochondria; N-Methylaspartate; Piperidines; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rhodamine 123; Rhodamines; Sulfonamides | 1997 |
Spinal neurokinin NK1 receptor down-regulation and antinociception: effects of spinal NK1 receptor antisense oligonucleotides and NK1 receptor occupancy.
Topics: Animals; Down-Regulation; Formaldehyde; Indoles; Injections, Spinal; Isoindoles; Male; N-Methylaspartate; Oligonucleotides, Antisense; Pain; Pain Threshold; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1998 |
Modulation of [3H]Dopamine release from rat nucleus accumbens by neuropeptide Y may involve a sigma1-like receptor.
Topics: Animals; Antipsychotic Agents; Dopamine; In Vitro Techniques; Male; N-Methylaspartate; Neuropeptide Y; Nucleus Accumbens; Pentazocine; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Structure-Activity Relationship | 1998 |
Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors.
Topics: Animals; Calcium; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Humans; Kidney; Kynurenic Acid; Membrane Potentials; Molecular Sequence Data; N-Methylaspartate; Oocytes; Patch-Clamp Techniques; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Xenopus laevis | 1998 |
Increased contribution of NR2A subunit to synaptic NMDA receptors in developing rat cortical neurons.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Electric Conductivity; Excitatory Amino Acid Antagonists; Haloperidol; In Vitro Techniques; N-Methylaspartate; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1998 |
Eliprodil, a non-competitive, NR2B-selective NMDA antagonist, protects pyramidal neurons in hippocampal slices from hypoxic/ischemic damage.
Topics: Animals; Excitatory Amino Acid Antagonists; Hippocampus; Hypoxia; In Vitro Techniques; Ischemia; Male; N-Methylaspartate; Neuroprotective Agents; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 1998 |
Characterization of desensitization in recombinant N-methyl-D-aspartate receptors: comparison with native receptors in cultured hippocampal neurons.
Topics: Allosteric Site; Animals; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Humans; Ion Channel Gating; Kidney; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins | 1998 |
Distinct modifications by neurokinin1 (SR140333) and neurokinin2 (SR48968) tachykinin receptor antagonists of the N-methyl-D-aspartate-evoked release of acetylcholine in striosomes and matrix of the rat striatum.
Topics: Acetylcholine; Animals; Benzamides; Dopamine; Excitatory Amino Acid Agonists; In Vitro Techniques; Male; N-Methylaspartate; Neostriatum; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-2; Stimulation, Chemical; Substance P | 1998 |
An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones.
Topics: Allosteric Regulation; Allosteric Site; Animals; Benzamides; Binding Sites; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Evoked Potentials; Excitatory Amino Acid Antagonists; Magnesium; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Pyridines; Rats; Receptors, N-Methyl-D-Aspartate; Spermine | 1998 |
Chronic interleukin-6 alters NMDA receptor-mediated membrane responses and enhances neurotoxicity in developing CNS neurons.
Topics: Animals; Calcium Channels; Calcium Signaling; Cell Membrane; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Interleukin-6; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 1998 |
NMDA receptor characterization and subunit expression in rat cultured mesencephalic neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Gene Expression; Gene Expression Regulation, Developmental; Glycine; Memantine; Mesencephalon; N-Methylaspartate; Neurons; Nitrendipine; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA Splicing; RNA, Messenger | 1999 |
Properties of NMDA receptors in rat spinal cord motoneurons.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Ion Channel Gating; Kainic Acid; Kynurenic Acid; Magnesium; Male; Motor Neurons; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Na+-K+-2Cl- cotransporter in immature cortical neurons: A role in intracellular Cl- regulation.
Topics: Animals; Biological Transport; Blotting, Western; Carrier Proteins; Cerebral Cortex; Chelating Agents; Chlorides; Egtazic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Immunohistochemistry; N-Methylaspartate; Neurons; Piperidines; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Sodium-Potassium-Chloride Symporters; Staining and Labeling | 1999 |
The 5-HT2A receptor antagonist M100907 is more effective in counteracting NMDA antagonist- than dopamine agonist-induced hyperactivity in mice.
Topics: Amphetamine; Animals; Dizocilpine Maleate; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fluorobenzenes; Glutamic Acid; Haloperidol; Hyperkinesis; Male; Mice; Mice, Inbred Strains; Motor Activity; N-Methylaspartate; Piperazines; Piperidines; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin Antagonists | 1999 |
Protection by eliprodil against excitotoxicity in cultured rat retinal ganglion cells.
Topics: Animals; Cell Death; Cells, Cultured; Drug Combinations; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Male; N-Methylaspartate; Neuroprotective Agents; Piperidines; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells | 1999 |
Neuroprotective effects of eliprodil in retinal excitotoxicity and ischemia.
Topics: Animals; Choline O-Acetyltransferase; Electroretinography; Injections; Injections, Intraperitoneal; Ischemia; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Piperidines; Rats; Rats, Long-Evans; Retina; Retinal Ganglion Cells; Retinal Vessels; Vitreous Body | 1999 |
Factors that enhance ethanol inhibition of N-methyl-D-aspartate receptors in cerebellar granule cells.
Topics: Animals; Animals, Newborn; Cell Line; Cells, Cultured; Cerebellum; Drug Synergism; Ethanol; Excitatory Amino Acid Antagonists; Glycine; Humans; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Time Factors; Transfection | 1999 |
Aniracetam, 1-BCP and cyclothiazide differentially modulate the function of NMDA and AMPA receptors mediating enhancement of noradrenaline release in rat hippocampal slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antihypertensive Agents; Benzothiadiazines; Dioxoles; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Heterocyclic Compounds; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Nootropic Agents; Norepinephrine; Piperidines; Pyrrolidinones; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tritium | 1999 |
Human retina contains polyamine sensitive [3H]-ifenprodil binding sites: implications for neuroprotection?
Topics: Aged; Aged, 80 and over; Biguanides; Binding Sites; Excitatory Amino Acid Antagonists; Humans; N-Methylaspartate; Neuroprotective Agents; Piperidines; Polyamines; Receptors, N-Methyl-D-Aspartate; Retina | 1999 |
Cannabinoid CB1 receptor-mediated inhibition of NMDA- and kainate-stimulated noradrenaline and dopamine release in the brain.
Topics: Animals; Benzoxazines; Binding, Competitive; Brain Chemistry; Cannabinoids; Cerebral Cortex; Cyclohexanols; Dopamine; Excitatory Amino Acid Agonists; Guinea Pigs; Kainic Acid; Male; Membranes; Morpholines; N-Methylaspartate; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stimulation, Chemical | 1999 |
Control by GABA and tachykinins of the evoked release of acetylcholine in striatal compartments under different modalities of NMDA receptor stimulation.
Topics: Acetylcholine; Animals; Benzamides; Bicuculline; Cell Compartmentation; Cells, Cultured; Corpus Striatum; Dopamine Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; N-Methylaspartate; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-2; Stimulation, Chemical; Sulpiride; Tachykinins | 2000 |
Sensitive gas chromatographic-mass spectrometric method for the determination of gacyclidine in rat plasma and spinal cord dialyzates.
Topics: Animals; Cyclohexanes; Cyclohexenes; Gas Chromatography-Mass Spectrometry; Male; Microdialysis; N-Methylaspartate; Piperidines; Rats; Rats, Wistar; Sensitivity and Specificity | 1999 |
Identification of subunits contributing to synaptic and extrasynaptic NMDA receptors in Golgi cells of the rat cerebellum.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebellum; Ethylenediamines; Evoked Potentials; Excitatory Amino Acid Antagonists; In Vitro Techniques; Microscopy, Confocal; N-Methylaspartate; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses | 2000 |
CP-101,606, an NR2B subunit selective NMDA receptor antagonist, inhibits NMDA and injury induced c-fos expression and cortical spreading depression in rodents.
Topics: Animals; Blotting, Northern; Brain Injuries; Cortical Spreading Depression; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression; Genes, fos; Hippocampus; Immunohistochemistry; Male; Mice; N-Methylaspartate; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 2000 |
Enhancement of NMDA-induced current by the putative NR2B selective antagonist ifenprodil.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 2000 |
The novel non-competitive N-methyl-D-aspartate antagonist gacyclidine blocks the glutamate-induced release of hydroxyl radicals in the striatum under conditions in which dizocilpine does not. A microdialysis study in rats.
Topics: Animals; Binding, Competitive; Corpus Striatum; Cyclohexanes; Cyclohexenes; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Hydroxyl Radical; Male; Microdialysis; N-Methylaspartate; Neuroprotective Agents; Oxidative Stress; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2000 |
Neuroprotective effects of a novel NMDA antagonist, Gacyclidine, after experimental contusive spinal cord injury in adult rats.
Topics: Animals; Contusions; Cyclohexanes; Cyclohexenes; Electrophysiology; Evoked Potentials, Somatosensory; Excitatory Amino Acid Antagonists; Male; Motor Activity; N-Methylaspartate; Neuroprotective Agents; Piperidines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Time Factors; Weight Gain | 2000 |
Brain-derived neurotrophic factor increases activity of NR2B-containing N-methyl-D-aspartate receptors in excised patches from hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; Animals; Brain-Derived Neurotrophic Factor; Cell Membrane; Cells, Cultured; Excitatory Amino Acid Antagonists; Guanosine Triphosphate; Hippocampus; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synaptic Transmission | 2000 |
Supraspinal vs spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil.
Topics: Analgesics; Animals; Decerebrate State; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Male; Memantine; Motor Activity; N-Methylaspartate; Naloxone; Narcotic Antagonists; Pain; Piperidines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2001 |
N-methyl-D-aspartate receptors mediating hippocampal noradrenaline and striatal dopamine release display differential sensitivity to quinolinic acid, the HIV-1 envelope protein gp120, external pH and protein kinase C inhibition.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; HIV Envelope Protein gp120; Hydrogen-Ion Concentration; Male; N-Methylaspartate; Norepinephrine; Piperidines; Protein Kinase C; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Synaptosomes; Zinc | 2001 |
Dynamic modulation of NMDA-induced responses by ifenprodil in rat prefrontal cortex.
Topics: Animals; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kinetics; Male; N-Methylaspartate; Perfusion; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 2001 |
Some of the effects of the selective sigma ligand (+)pentazocine are mediated via a naloxone-sensitive receptor.
Topics: Action Potentials; Animals; Cinnamates; Cyclazocine; Cyclohexylamines; Cyclopropanes; Excitatory Amino Acid Agonists; Injections, Intravenous; Male; N-Methylaspartate; Naloxone; Narcotic Antagonists; Pentazocine; Piperidines; Pyramidal Cells; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, sigma | 2001 |
Facilitation of Ca2+ store-dependent noradrenaline release after an N-methyl-D-aspartate receptor antagonist in the rat supraoptic nucleus.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Desipramine; Excitatory Amino Acid Antagonists; Male; Microdialysis; N-Methylaspartate; Norepinephrine; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Supraoptic Nucleus; Tetrodotoxin | 2001 |
Characterization of the single-channel properties of NMDA receptors in laminae I and II of the dorsal horn of neonatal rat spinal cord.
Topics: Aging; Animals; Excitatory Amino Acid Antagonists; Ion Channels; Magnesium; Membrane Potentials; N-Methylaspartate; Nociceptors; Pain; Patch-Clamp Techniques; Piperidines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2001 |
Facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after acute and chronic suppression of dopaminergic transmission in the matrix of the rat striatum.
Topics: Acetylcholine; Animals; Benzamides; Corpus Striatum; Dopamine; Dopamine Antagonists; Enzyme Inhibitors; In Vitro Techniques; Male; N-Methylaspartate; Neural Inhibition; Neurons; Oxidopamine; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Synaptic Transmission; Tachykinins; Time Factors | 2002 |
Distinct NMDA receptors provide differential modes of transmission at mossy fiber-interneuron synapses.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Calcium; Chlorides; Cyclopropanes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Interneurons; Mossy Fibers, Hippocampal; N-Methylaspartate; Patch-Clamp Techniques; Phenols; Piperidines; Polyamines; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Valine | 2002 |
Molecular modeling of noncompetitive antagonists of the NMDA receptor: proposal of a pharmacophore and a description of the interaction mode.
Topics: Binding Sites; Dioxolanes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ketamine; Lipids; Models, Molecular; Molecular Structure; N-Methylaspartate; Nitrogen; Phencyclidine; Piperidines; Quinolines; Receptors, N-Methyl-D-Aspartate; Static Electricity | 2002 |
Blockade of cannabinoid CB(1) receptor function protects against in vivo disseminating brain damage following NMDA-induced excitotoxicity.
Topics: Animals; Benzoxazines; Brain; Cannabinoids; Cell Survival; Cerebral Cortex; Corpus Striatum; Morpholines; N-Methylaspartate; Naphthalenes; Neurodegenerative Diseases; Neurotoxins; Parietal Lobe; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Spermidine attenuates the inhibitory effect of ethanol on NMDA-induced neurotoxicity.
Topics: Analysis of Variance; Animals; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; N-Methylaspartate; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spermidine | 2002 |
Differential regulation of synaptic and extra-synaptic NMDA receptors.
Topics: Animals; Calcium; Calcium Signaling; Cell Membrane; Cells, Cultured; Endocytosis; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; N-Methylaspartate; Phosphoric Monoester Hydrolases; Piperidines; Protein Transport; Protein-Tyrosine Kinases; Pyramidal Cells; Rats; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2002 |
Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; Dizocilpine Maleate; Ethanol; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; Kynurenic Acid; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Piperidines; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; RNA Splicing | 2003 |
Selective blockade of endothelin-B receptors exacerbates ischemic brain damage in the rat.
Topics: Animals; Antihypertensive Agents; Blood Flow Velocity; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Endothelin Receptor Antagonists; Excitatory Amino Acid Agonists; Gene Expression; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Male; N-Methylaspartate; Oligopeptides; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Receptors, Endothelin; RNA, Messenger | 2002 |
Comparison of effect of ethanol on N-methyl-D-aspartate- and GABA-gated currents from acutely dissociated neurons: absence of regional differences in sensitivity to ethanol.
Topics: Anesthetics; Animals; Brain; Brain Chemistry; Cell Line; Central Nervous System Depressants; CHO Cells; Cricetinae; Electrophysiology; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Ion Channel Gating; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Pregnanediones; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 2003 |
Excitatory amino acid receptors of the electrosensory system: the NR1/NR2B N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Cells, Cultured; Conserved Sequence; DNA, Complementary; Electric Fish; Electric Organ; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Kidney; Molecular Sequence Data; N-Methylaspartate; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transfection | 2003 |
Protein kinase C is involved in clozapine's facilitation of N-methyl-D-aspartate- and electrically evoked responses in pyramidal cells of the medial prefrontal cortex.
Topics: Alkaloids; Animals; Benzophenanthridines; Clozapine; Drug Interactions; Electric Stimulation; Electrophysiology; Enzyme Activators; Enzyme Inhibitors; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Fluorobenzenes; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Mice; Mice, Knockout; Mice, Mutant Strains; N-Methylaspartate; Peptide Fragments; Phenanthridines; Phorbols; Piperidines; Protein Kinase C; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Tetradecanoylphorbol Acetate; Time Factors | 2003 |
Functional NMDA receptor subtype 2B is expressed in astrocytes after ischemia in vivo and anoxia in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Axotomy; Brain Ischemia; Calcium; Cell Hypoxia; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Male; N-Methylaspartate; Neurons; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2003 |
Thrombin inhibits NMDA-mediated nociceptive activity in the mouse: possible mediation by endothelin.
Topics: Acetic Acid; Amino Acid Chloromethyl Ketones; Animals; Behavior, Animal; Capillary Permeability; Endothelins; Evans Blue; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hyperalgesia; Indazoles; Injections, Intraperitoneal; Male; Mice; N-Methylaspartate; Nociceptors; Oligopeptides; Pain Measurement; Peptide Fragments; Peptides, Cyclic; Physical Stimulation; Piperidines; Reaction Time; Receptor, Endothelin A; Receptor, Endothelin B; Thrombin; Urea | 2003 |
Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Gallic Acid; Guanidines; Indazoles; Injections, Intraperitoneal; Kynurenic Acid; Molsidomine; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroprusside; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
NR2B and NR2D subunits coassemble in cerebellar Golgi cells to form a distinct NMDA receptor subtype restricted to extrasynaptic sites.
Topics: Animals; Cerebellum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Kinetics; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Synapses | 2003 |
Acute dissociation for analyses of NMDA receptor function in cortical neurons during aging.
Topics: Aging; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate; Time Factors | 2003 |
The new neurokinin 1-sensitive receptor mediates the facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after suppression of dopaminergic transmission in the matrix of the rat striatum.
Topics: Acetylcholine; alpha-Methyltyrosine; Animals; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Morpholines; N-Methylaspartate; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Perfusion; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Synaptic Transmission; Tachykinins; Tetrazoles | 2003 |
NMDA currents and receptor protein are downregulated in the amygdala during maintenance of fear memory.
Topics: Amygdala; Animals; Down-Regulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fear; In Vitro Techniques; Male; Memory; N-Methylaspartate; Neuronal Plasticity; Phosphorylation; Piperidines; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex, Startle | 2003 |
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae.
Topics: Alanine; Animals; Biguanides; Calcium Channel Blockers; Cattle; D-Aspartic Acid; Diltiazem; Dizocilpine Maleate; Drug Synergism; Glucose; Glutamic Acid; Glycine; Humans; Kainic Acid; N-Methylaspartate; Nitrendipine; omega-Conotoxins; Perfusion; Piperidines; Polyamines; Receptors, Glutamate; Retina; Tritium; Verapamil | 2003 |
Differential role of poly(ADP-ribose) polymerase-1in apoptotic and necrotic neuronal death induced by mild or intense NMDA exposure in vitro.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Isoquinolines; Mice; Models, Biological; N-Methylaspartate; Necrosis; Neurons; Neurotoxins; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases | 2004 |
Effects of NMDA receptor-related agonists on learning and memory impairment in olfactory bulbectomized mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Cycloserine; Disease Models, Animal; Dizocilpine Maleate; Drug Therapy, Combination; Injections, Intraventricular; Male; Memory Disorders; Mice; N-Methylaspartate; Olfactory Bulb; Piperidines; Receptors, N-Methyl-D-Aspartate; Spermidine; Time Factors | 2004 |
Retrograde activation of presynaptic NMDA receptors enhances GABA release at cerebellar interneuron-Purkinje cell synapses.
Topics: Animals; Animals, Newborn; Cadmium; Calcium; Cerebellum; Chelating Agents; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Immunohistochemistry; In Vitro Techniques; Interneurons; Isoenzymes; Membrane Potentials; N-Methylaspartate; Neural Inhibition; Neuronal Plasticity; Patch-Clamp Techniques; Piperidines; Presynaptic Terminals; Purkinje Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rimonabant; Ryanodine; Sodium Channel Blockers; Synapses; Synaptic Transmission; Synaptophysin; Tetrodotoxin; Time Factors | 2004 |
Cannabinoids enhance N-methyl-D-aspartate-induced excitation of locus coeruleus neurons by CB1 receptors in rat brain slices.
Topics: Action Potentials; Analgesics; Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cyclohexanols; Drug Interactions; Electrophysiology; Endocannabinoids; Excitatory Amino Acid Agonists; In Vitro Techniques; Locus Coeruleus; Male; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
Characterization of the non-competitive antagonist binding site of the NMDA receptor in dark Agouti rats.
Topics: Animals; Binding, Competitive; Brain; Dextromethorphan; Dioxolanes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Ketamine; N-Methylaspartate; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Mutant Strains; Receptors, N-Methyl-D-Aspartate; Scintillation Counting; Tritium | 2004 |
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Phenols; Picrotoxin; Piperidines; Protein Subunits; Pyrrolidines; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2004 |
Distinct modulatory roles of sigma receptor subtypes on glutamatergic responses in the dorsal hippocampus.
Topics: Action Potentials; Analysis of Variance; Animals; Anisoles; Antipsychotic Agents; Benzamides; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Male; N-Methylaspartate; Piperidines; Propylamines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, sigma | 2005 |
BDNF enhancement of postsynaptic NMDA receptors is blocked by ethanol.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Central Nervous System Depressants; Drug Interactions; Ethanol; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Membrane Potentials; Mice; N-Methylaspartate; Neocortex; Patch-Clamp Techniques; Phenols; Piperidines; Pyramidal Cells; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors | 2005 |
Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Methylazoxymethanol Acetate; N-Methylaspartate; Patch-Clamp Techniques; Piperidines; Rats | 2005 |
Striatal glutamate release evoked in vivo by NMDA is dependent upon ongoing neuronal activity in the substantia nigra, endogenous striatal substance P and dopamine.
Topics: Adrenergic Agents; Animals; Benzazepines; Bicuculline; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; Glutamic Acid; Magnesium; Male; N-Methylaspartate; Neurons; Oxidopamine; Piperidines; Potassium Chloride; Quinuclidines; Raclopride; Rats; Rats, Sprague-Dawley; Substance P; Substantia Nigra; Tetrodotoxin; Time Factors | 2005 |
Protective effects of Delta(9)-tetrahydrocannabinol against N-methyl-d-aspartate-induced AF5 cell death.
Topics: alpha-Tocopherol; Animals; Benzimidazoles; Benzoxazines; Blotting, Northern; Blotting, Western; Calcium Channel Blockers; Calcium Channels; Capsaicin; Cell Count; Cell Death; Cell Lineage; Dizocilpine Maleate; DNA, Single-Stranded; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Excitatory Amino Acid Agonists; Immunohistochemistry; In Situ Nick-End Labeling; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Ruthenium; Tetrazolium Salts; Thiazoles; TRPC Cation Channels | 2005 |
Diminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapses.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Count; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamate Decarboxylase; Hippocampus; Immunohistochemistry; Isoenzymes; Ketamine; Membrane Potentials; N-Methylaspartate; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Statistics, Nonparametric; Synapses; Synaptic Transmission; Synaptophysin; Tetrodotoxin; Time Factors | 2005 |
Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores.
Topics: Animals; Benzoxazines; Calcium; Cell Culture Techniques; Cell Death; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclohexanols; Dantrolene; Drug Interactions; Estrenes; Fetus; Hippocampus; Macrocyclic Compounds; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Okadaic Acid; Oxazoles; Piperidines; Pyrazoles; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptor, Cannabinoid, CB1; Rimonabant; Ryanodine; Thionucleotides | 2005 |
Dual Ca2+ modulation of glycinergic synaptic currents in rodent hypoglossal motoneurones.
Topics: Animals; Benzoxazines; Calcium; Cannabinoid Receptor Modulators; Glutamic Acid; Glycine; Hypoglossal Nerve; In Vitro Techniques; Membrane Potentials; Mice; Morpholines; Motor Neurons; N-Methylaspartate; Naphthalenes; Neural Inhibition; Piperidines; Presynaptic Terminals; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cannabinoid; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Rimonabant; Synaptic Transmission | 2005 |
Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity.
Topics: Animals; Benzoxazines; Cannabinoids; Cells, Cultured; Cerebral Cortex; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Mice; Mice, Knockout; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type I; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
Protective effect of donepezil in primary-cultured rat cortical neurons exposed to N-methyl-d-aspartate (NMDA) toxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Indans; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neuroprotective Agents; Nootropic Agents; Piperidines; Rats; Rats, Wistar; Receptors, Glutamate | 2006 |
Novel blockade of protein kinase A-mediated phosphorylation of AMPA receptors.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic beta-Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Calcineurin Inhibitors; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclosporine; Egtazic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gs; Hippocampus; Isoproterenol; Long-Term Potentiation; Male; Marine Toxins; Mice; Mice, Inbred C57BL; N-Methylaspartate; Oxazoles; Phenols; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Piperidines; Protein Phosphatase 1; Protein Phosphatase 2; Protein Processing, Post-Translational; Receptors, Adrenergic, beta-1; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2006 |
Early chronic blockade of NR2B subunits and transient activation of NMDA receptors modulate LTP in mouse auditory cortex.
Topics: Analysis of Variance; Animals; Auditory Cortex; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Infusion Pumps, Implantable; Long-Term Potentiation; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; N-Methylaspartate; Piperidines; Receptors, N-Methyl-D-Aspartate; Time Factors | 2006 |
Sigma2 (sigma2) receptors as a target for cocaine action in the rat striatum.
Topics: Animals; Benzylamines; Calcium; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Indoles; Male; Maleimides; Mesylates; N-Methylaspartate; Nomifensine; Pentazocine; Piperidines; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sigma-1 Receptor; Spiro Compounds; Sulfonamides; Tritium | 2006 |
Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors.
Topics: Age Factors; Animals; Biomarkers; Calpain; Dipeptides; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Enzyme Activation; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Gene Expression Regulation, Developmental; Glucose; Hippocampus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; L-Lactate Dehydrogenase; Membrane Proteins; N-Methylaspartate; Neurons; Oxygen; Phenols; Piperidines; Propidium; Protein Subunits; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spectrin; Valine | 2006 |
A genetically modified mouse model probing the selective action of ifenprodil at the N-methyl-D-aspartate type 2B receptor.
Topics: Animals; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Gene Targeting; Hippocampus; Humans; Male; Mice; Mice, Transgenic; Motor Activity; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Xenopus laevis | 2006 |
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression.
Topics: Animals; Animals, Newborn; Calcium; Dose-Response Relationship, Radiation; Electric Stimulation; Enzyme Activation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; N-Methylaspartate; Patch-Clamp Techniques; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2007 |
Alteration in sensitivity of ionotropic glutamate receptors and tachykinin receptors in spinal cord contribute to development and maintenance of nerve injury-evoked neuropathic pain.
Topics: Alanine; Analgesics; Animals; Behavior, Animal; Benzamides; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Indoles; Isoindoles; Male; N-Methylaspartate; Pain; Pain Measurement; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Tachykinin; Sciatic Nerve; Spinal Cord; Substance P; Valine | 2006 |
Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus.
Topics: Animals; Animals, Newborn; Cell Line, Transformed; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hippocampus; Humans; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Patch-Clamp Techniques; Phenols; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Transfection | 2007 |
Brain-derived neurotrophic factor regulation of N-methyl-D-aspartate receptor-mediated synaptic currents in suprachiasmatic nucleus neurons.
Topics: Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Immunoglobulin G; In Vitro Techniques; Indole Alkaloids; Male; Membrane Potentials; N-Methylaspartate; Neurons; Optic Nerve; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Suprachiasmatic Nucleus | 2006 |
Developmental switch from LTD to LTP in low frequency-induced plasticity.
Topics: Age Factors; Animals; Animals, Newborn; Benzoxazines; Calcium Channel Blockers; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glycine; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Morpholines; N-Methylaspartate; Naphthalenes; Phenylacetates; Piperidines; Pyrazoles; Rats | 2006 |
Carnosine protects against NMDA-induced neurotoxicity in differentiated rat PC12 cells through carnosine-histidine-histamine pathway and H(1)/H(3) receptors.
Topics: Animals; Carnosine; Cell Differentiation; gamma-Aminobutyric Acid; Glutamic Acid; Histamine; Histidine; Methylhistidines; N-Methylaspartate; Neurons; PC12 Cells; Piperidines; Rats; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3 | 2007 |
NK-1 receptors modulate the excitability of ON cells in the rostral ventromedial medulla.
Topics: Animals; Capsaicin; Electrophysiology; Excitatory Amino Acid Agonists; Extracellular Space; Immunohistochemistry; Iontophoresis; Male; Medulla Oblongata; Microscopy, Confocal; N-Methylaspartate; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2007 |
Glutamate exocytosis from astrocytes controls synaptic strength.
Topics: Analysis of Variance; Animals; Astrocytes; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exocytosis; Glutamic Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; Microscopy, Immunoelectron; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Perforant Pathway; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2007 |
Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors.
Topics: Analysis of Variance; Animals; Calcium Channel Blockers; Cell Death; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Mice; Mice, Knockout; Mutation; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Time Factors | 2007 |
Cleft-type cyclophanes confer neuroprotection against excitatory neurotoxicity in vitro and in vivo through inhibition of NMDA receptors.
Topics: Animals; Cell Line, Tumor; Ethers, Cyclic; Female; Hippocampus; Larva; Mice; N-Methylaspartate; Neuroblastoma; Neurons; Neuroprotective Agents; Neurotoxins; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Xenopus | 2007 |
Discovery of (-)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone--a potent NR2B-selective N-methyl D-aspartate (NMDA) antagonist for the treatment of pain.
Topics: Animals; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Enzyme Inhibitors; Ether-A-Go-Go Potassium Channels; Inhibitory Concentration 50; Molecular Structure; N-Methylaspartate; Pain; Piperidines; Quinolones; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2007 |
Brain-derived neurotrophic factor activation of extracellular signal-regulated kinase is autonomous from the dominant extrasynaptic NMDA receptor extracellular signal-regulated kinase shutoff pathway.
Topics: Animals; Blotting, Western; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Dizocilpine Maleate; Enzyme Activation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extracellular Signal-Regulated MAP Kinases; Extracellular Space; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phenols; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2008 |
Orexin-A modulates glutamatergic NMDA-dependent spinal reflex potentiation via inhibition of NR2B subunit.
Topics: Action Potentials; Animals; Electromyography; Excitatory Amino Acid Antagonists; Female; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; N-Methylaspartate; Neurons, Afferent; Neuropeptides; Orexins; Piperazines; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex; Spinal Cord; Synaptic Transmission; Urethra | 2008 |
Study of neuroprotection of donepezil, a therapy for Alzheimer's disease.
Topics: Animals; Cholinesterase Inhibitors; Donepezil; In Vitro Techniques; Indans; N-Methylaspartate; Neuroprotective Agents; Piperidines; Rats; Rats, Wistar | 2008 |
Late phase of long-term potentiation induced by co-application of N-methyl-d-aspartic acid and the antagonist of NR2B-containing N-methyl-d-aspartic acid receptors in rat hippocampus.
Topics: Analysis of Variance; Animals; Biophysics; Drug Combinations; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; N-Methylaspartate; Phenols; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2009 |
Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons.
Topics: Actins; Animals; Becaplermin; Calcium; Cyclic AMP Response Element-Binding Protein; Cytoskeleton; Hippocampus; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; N-Methylaspartate; Neurons; Phenols; Phospholipase C gamma; Piperidines; Platelet-Derived Growth Factor; Protein Kinase C; Proto-Oncogene Proteins c-sis; Rats; Rats, Wistar; Receptor, Platelet-Derived Growth Factor beta; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2009 |
Discovery of GlyT1 inhibitors with improved pharmacokinetic properties.
Topics: Animals; Dogs; Drug Discovery; Glycine; Glycine Plasma Membrane Transport Proteins; Humans; Mice; Mice, Inbred DBA; N-Methylaspartate; Piperidines; Rats; Substrate Specificity; Sulfonamides | 2009 |
NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Ketamine; Lithium Chloride; Male; Mice; Models, Animal; Motor Activity; N-Methylaspartate; Piperidines; Receptors, N-Methyl-D-Aspartate; Swimming; Time Factors | 2010 |
The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B.
Topics: Amino Acid Sequence; Animals; Cell Line; Conotoxins; Excitatory Amino Acid Antagonists; Glycine; Humans; Membrane Potentials; Models, Molecular; Molecular Sequence Data; N-Methylaspartate; Patch-Clamp Techniques; Piperidines; Point Mutation; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins | 2009 |
Endocannabinoids mediate tachykinin-induced effects in the lamprey locomotor network.
Topics: Action Potentials; Analgesics; Animals; Benzoxazines; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Endocannabinoids; Excitatory Amino Acid Agonists; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Interneurons; Lampreys; Locomotion; Models, Biological; Morpholines; N-Methylaspartate; Naphthalenes; Nerve Net; Neural Pathways; Neurotransmitter Agents; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Spinal Cord; Substance P; Tachykinins | 2009 |
Adenosine A2A receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum.
Topics: Action Potentials; Animals; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Cerebral Cortex; Corpus Striatum; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Agonists; Female; Glycine; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Mice; Mice, Knockout; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Phenylacetates; Piperidines; Pregnancy; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Adenosine A2; Synapses; Triazines; Triazoles | 2009 |
Signaling pathways from cannabinoid receptor-1 activation to inhibition of N-methyl-D-aspartic acid mediated calcium influx and neurotoxicity in dorsal root ganglion neurons.
Topics: Animals; Benzoxazines; Calcium; Camphanes; Cell Culture Techniques; Cell Death; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Ganglia, Spinal; Mice; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction | 2009 |
Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors.
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Valine | 2010 |
Histamine potentiates N-methyl-D-aspartate receptors by interacting with an allosteric site distinct from the polyamine binding site.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Site; Animals; Binding Sites; Calcium; Dizocilpine Maleate; Drug Synergism; Hippocampus; Histamine; In Vitro Techniques; Intracellular Space; Male; Methylhistamines; N-Methylaspartate; Neurons; Norepinephrine; Piperidines; Polyamines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Synaptosomes | 2010 |
Early functional outcomes and histological analysis after spinal cord compression injury in rats.
Topics: Animals; Autonomic Nervous System; Catheterization; Cyclohexenes; Disease Models, Animal; Excitatory Amino Acid Antagonists; Male; Motor Activity; N-Methylaspartate; Piperidines; Rats; Rats, Wistar; Reflex; Sensory Receptor Cells; Spinal Cord; Spinal Cord Compression; Spinal Cord Injuries; Urination | 2010 |
N-methyl-D-aspartate-evoked adenosine and inosine release from neurons requires extracellular calcium.
Topics: Adenosine; Animals; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebral Cortex; Chelating Agents; Dizocilpine Maleate; Egtazic Acid; Excitatory Amino Acid Antagonists; Inosine; N-Methylaspartate; Neurons; Piperidines; Purines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 2009 |
NMDA receptor contributions to visual contrast coding.
Topics: Animals; Contrast Sensitivity; Dizocilpine Maleate; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Guinea Pigs; In Vitro Techniques; Light; Mice; Mice, Inbred C57BL; N-Methylaspartate; Patch-Clamp Techniques; Photic Stimulation; Piperidines; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Visual Perception | 2010 |
An examination of NMDA receptor contribution to conditioned responding evoked by the conditional stimulus effects of nicotine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Conditioning, Classical; Cyclopentanes; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Mecamylamine; N-Methylaspartate; Nicotine; Phencyclidine; Phenols; Piperazines; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2011 |
Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions.
Topics: Animals; Aspartic Acid; Calcium; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Hippocampus; Immunoprecipitation; Magnesium; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tetrahydronaphthalenes; Tritium | 2011 |
mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch.
Topics: Adaptation, Physiological; Animals; Animals, Newborn; Electric Stimulation; Enzyme Inhibitors; Estrenes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Knockout; Models, Biological; N-Methylaspartate; Piperidines; Pyramidal Cells; Pyridines; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Thiazoles; Time Factors; Visual Cortex | 2011 |
NR2B phosphorylation at tyrosine 1472 in spinal dorsal horn contributed to N-methyl-D-aspartate-induced pain hypersensitivity in mice.
Topics: Animals; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Mice; N-Methylaspartate; Pain Measurement; Phosphorylation; Piperidines; Posterior Horn Cells; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; Synapses | 2011 |
Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo.
Topics: Action Potentials; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Brain Waves; Calcium; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Electroencephalography; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Extracellular Space; Flavones; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; N-Methylaspartate; Piperazines; Piperidines; Pregnanolone; Presenilin-1; Receptors, N-Methyl-D-Aspartate; Serotonin; Sodium Channel Blockers; Synapses; Tetrodotoxin | 2011 |
Synthesis of a series of γ-amino alcohols comprising an N-methyl isoindoline moiety and their evaluation as NMDA receptor antagonists.
Topics: Amino Alcohols; Binding Sites; Dizocilpine Maleate; Drug Design; Ether-A-Go-Go Potassium Channels; Excitatory Amino Acid Antagonists; Inhibitory Concentration 50; Ligands; Molecular Structure; Molecular Targeted Therapy; N-Methylaspartate; Neuroprotective Agents; Piperidines; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 2011 |
Ifenprodil restores GDNF-evoked Ca(2+) signalling and Na(+)/K(+) -ATPase expression in inflammation-pretreated astrocytes.
Topics: Animals; Area Under Curve; Astrocytes; Calcium; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Dose-Response Relationship, Drug; Drug Interactions; Endothelial Cells; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Interleukin-1beta; Lipopolysaccharides; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Sodium-Potassium-Exchanging ATPase | 2011 |
Pharmacological activation/inhibition of the cannabinoid system affects alcohol withdrawal-induced neuronal hypersensitivity to excitotoxic insults.
Topics: Animals; Cannabinoids; Cell Death; Cells, Cultured; Ethanol; Excitatory Amino Acid Agonists; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Substance Withdrawal Syndrome | 2011 |
Activity dependent protein degradation is critical for the formation and stability of fear memory in the amygdala.
Topics: Amygdala; Animals; Conditioning, Psychological; Cysteine Proteinase Inhibitors; DNA Helicases; Excitatory Amino Acid Antagonists; Fear; Immunoblotting; Lactones; Male; Memory; Memory, Long-Term; N-Methylaspartate; Neuronal Plasticity; Piperidines; Proteasome Endopeptidase Complex; Proteolysis; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors; Ubiquitin; Ubiquitination | 2011 |
Role of GluN2A and GluN2B subunits in the formation of filopodia and secondary dendrites in cultured hippocampal neurons.
Topics: Animals; Azabicyclo Compounds; Cells, Cultured; Dendrites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; HeLa Cells; Hippocampus; Humans; N-Methylaspartate; Neurons; Organophosphonates; Phenols; Piperidines; Protein Subunits; Pseudopodia; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 2012 |
Gating the polarity of endocannabinoid-mediated synaptic plasticity by nitric oxide in the spinal locomotor network.
Topics: Animals; Arachidonic Acids; Benzodioxoles; Cannabinoid Receptor Modulators; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Glycerides; Lactones; Lampreys; Locomotion; Male; N-Methylaspartate; Nerve Net; Neuronal Plasticity; Neurotransmitter Agents; Nitric Oxide; Orlistat; Patch-Clamp Techniques; Piperidines; Receptor, Cannabinoid, CB1; Spinal Cord; Synaptic Transmission | 2012 |
Creatine increases hippocampal Na(+),K(+)-ATPase activity via NMDA-calcineurin pathway.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cell Membrane; Creatine; Cyclic AMP-Dependent Protein Kinases; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Isoenzymes; Male; N-Methylaspartate; Nerve Tissue Proteins; Nitric Oxide Synthase; Piperidines; Protein Kinase C; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sodium-Potassium-Exchanging ATPase | 2012 |
Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons.
Topics: Animals; Blotting, Western; Calcium Signaling; Cell Survival; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phenols; Piperidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Sodium-Calcium Exchanger | 2012 |
[Remifentanil: a neuroprotective effect on the developing brain?].
Topics: Anesthetics, Intravenous; Apoptosis; Brain; Humans; Infant, Newborn; N-Methylaspartate; Neuroprotective Agents; Piperidines; Receptors, N-Methyl-D-Aspartate; Remifentanil | 2012 |
Endogenous acetylcholine rescues NMDA-induced long-lasting hippocampal cell damage via stimulation of muscarinic M(1) receptors: elucidation using organic hippocampal slice cultures.
Topics: Acetylcholine; Animals; Blotting, Western; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Galantamine; Hippocampus; Indans; Mice; Mice, Inbred ICR; N-Methylaspartate; Organ Culture Techniques; Piperidines; Receptor, Muscarinic M1; Tacrine | 2013 |
Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage.
Topics: Animals; Arachidonic Acids; Astrocytes; Benzodioxoles; Cell Survival; Endocannabinoids; Female; Gene Knockdown Techniques; Glycerides; Hippocampus; Lipoprotein Lipase; Microglia; Monoacylglycerol Lipases; N-Methylaspartate; Neurons; Perforant Pathway; Piperidines; Protein Transport; Rats, Wistar; Transcription, Genetic; Up-Regulation | 2012 |
The histamine H₃-receptor inverse agonist pitolisant improves fear memory in mice.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fear; Female; Histamine Agonists; Memory; Mice; Mice, Inbred C57BL; N-Methylaspartate; Piperidines | 2013 |
Synthesis and in vitro characterisation of ifenprodil-based fluorescein conjugates as GluN1/GluN2B N-Methyl-D-aspartate receptor antagonists.
Topics: Animals; Binding Sites; Brain; Calcium; Cells, Cultured; Fluorescein; HEK293 Cells; Humans; Male; Mice; Models, Molecular; N-Methylaspartate; Neurons; Neuroprotective Agents; Piperidines; Radiography; Receptors, N-Methyl-D-Aspartate | 2013 |
Low doses of the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, induces social facilitation in adolescent male rats.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; N-Methylaspartate; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Social Facilitation | 2013 |
Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Agonists; Cholinergic Antagonists; Cognition; Female; Iontophoresis; Macaca mulatta; Male; Mecamylamine; Microscopy, Immunoelectron; N-Methylaspartate; Phenols; Piperidines; Prefrontal Cortex; Quinuclidines; Receptors, Nicotinic; Spatial Behavior; Synapses; Visual Perception | 2013 |
Involvement of the nucleus accumbens shell glutamatergic system in ACPA-induced impairment of inhibitory avoidance memory consolidation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arachidonic Acids; Avoidance Learning; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Memory; Memory Disorders; Motor Activity; N-Methylaspartate; Nucleus Accumbens; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2014 |
D-serine-induced inactivation of NMDA receptors in cultured rat hippocampal neurons expressing NR2A subunits is Ca2+-dependent.
Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Chelating Agents; Egtazic Acid; Embryo, Mammalian; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine | 2014 |
Anti-aversive role of the endocannabinoid system in the periaqueductal gray stimulation model of panic attacks in rats.
Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Behavior, Animal; Benzamides; Carbamates; Disease Models, Animal; Endocannabinoids; Enzyme Inhibitors; Male; N-Methylaspartate; Panic Disorder; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2015 |
Modulating actions of NMDA receptors on pronociceptive effects of locally injected remifentanil in diabetic rats.
Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hyperalgesia; Malondialdehyde; N-Methylaspartate; Nitric Oxide; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Remifentanil; Streptozocin | 2014 |
The dual effect of CA1 NMDA receptor modulation on ACPA-induced amnesia in step-down passive avoidance learning task.
Topics: 2-Amino-5-phosphonovalerate; Amnesia; Analysis of Variance; Animals; Arachidonic Acids; Avoidance Learning; CA1 Region, Hippocampal; Cannabinoid Receptor Agonists; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Excitatory Amino Acid Antagonists; Exploratory Behavior; Male; Mice; Microinjections; N-Methylaspartate; Piperidines; Pyrazoles; Receptors, N-Methyl-D-Aspartate | 2015 |
Alteration of the Centromedial Amygdala Glutamatergic Synapses by the BDNF Val66Met Polymorphism.
Topics: Animals; Brain-Derived Neurotrophic Factor; Central Amygdaloid Nucleus; Conditioning, Classical; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extinction, Psychological; Fear; Glutamic Acid; In Vitro Techniques; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Neurons; Piperidines; Polymorphism, Single Nucleotide; Synapses; Valine | 2015 |
Contribution of extrasynaptic N-methyl-D-aspartate and adenosine A1 receptors in the generation of dendritic glutamate-mediated plateau potentials.
Topics: Animals; Dendrites; Diazonium Compounds; Glutamic Acid; Mice; N-Methylaspartate; Piperidines; Prefrontal Cortex; Pyramidal Cells; Pyridines; Receptor, Adenosine A1; Receptors, N-Methyl-D-Aspartate; Synaptic Potentials | 2015 |
Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene.
Topics: Animals; Carrier Proteins; Cells, Cultured; Central Nervous System Depressants; Electric Capacitance; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Homer Scaffolding Proteins; Kainic Acid; Membrane Potentials; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate | 2016 |
Role of the endocannabinoid 2-arachidonoylglycerol in aversive responses mediated by the dorsolateral periaqueductal grey.
Topics: Animals; Arachidonic Acids; Biphenyl Compounds; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Fluorescent Antibody Technique; Glycerides; Male; N-Methylaspartate; Panic Disorder; Periaqueductal Gray; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2016 |
Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits.
Topics: Anesthesia; Animals; Blotting, Western; Dioxoles; Learning; Mice; N-Methylaspartate; Neuronal Plasticity; Neurons; Piperidines; Receptors, AMPA; Synaptosomes | 2016 |
Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects against Amyloid-β-Induced Neurotoxicity.
Topics: Amyloid beta-Peptides; Animals; Antimetabolites; Cycloserine; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Locomotion; Male; Maze Learning; N-Methylaspartate; Nesting Behavior; Neurotoxicity Syndromes; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology; Signal Transduction; Synapses | 2017 |
CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Excitatory Amino Acid Antagonists; Guanylate Kinases; Hippocampus; Kainic Acid; Membrane Proteins; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Piperidines; Post-Synaptic Density; Protein Serine-Threonine Kinases; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Seizures; Tissue Culture Techniques | 2017 |
Inhibition of Cdk5 rejuvenates inhibitory circuits and restores experience-dependent plasticity in adult visual cortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cyclin-Dependent Kinase 5; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuronal Plasticity; Neurons; Phosphopyruvate Hydratase; Piperidines; Pyridazines; Sensory Deprivation; Visual Cortex; Visual Pathways | 2018 |
Injecting NMDA and Ro 25-6981 in insular cortex induce neuroplastic changes and neuropathic pain-like behaviour.
Topics: Animals; Central Nervous System Sensitization; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Agonists; Male; N-Methylaspartate; Neural Cell Adhesion Molecule L1; Neuralgia; Neuronal Plasticity; Pain Threshold; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Sialic Acids | 2018 |
Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis.
Topics: Animals; Benzoates; Biphenyl Compounds; Brain; Calcium; Carbamates; Cells, Cultured; Encephalomyelitis, Autoimmune, Experimental; Female; Inflammation; Mice; Mitochondria; Molecular Targeted Therapy; Monoacylglycerol Lipases; N-Methylaspartate; Neural Conduction; Piperidines; Pyramidal Tracts; Receptor, Cannabinoid, CB1; Triazoles | 2018 |
Hypothalamic endocannabinoid signalling modulates aversive responses related to panic attacks.
Topics: Animals; Arachidonic Acids; Benzamides; Biphenyl Compounds; Blood Pressure; Cannabinoids; Carbamates; Corticosterone; Dorsomedial Hypothalamic Nucleus; Endocannabinoids; Indoles; Male; Microinjections; N-Methylaspartate; Panic Disorder; Piperidines; Pyrazoles; Rats | 2019 |
Cannabidiol-induced panicolytic-like effects and fear-induced antinociception impairment: the role of the CB
Topics: Animals; Cannabidiol; Fear; Injections, Intraventricular; Male; N-Methylaspartate; Pain Measurement; Panic Disorder; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Ventromedial Hypothalamic Nucleus | 2020 |
Mu-opioid and CB1 cannabinoid receptors of the dorsal periaqueductal gray interplay in the regulation of fear response, but not antinociception.
Topics: Analgesics, Opioid; Animals; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Agonists; Fear; Freezing Reaction, Cataleptic; Male; Microinjections; N-Methylaspartate; Nociception; Pain; Pain Measurement; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Somatostatin | 2020 |
THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dronabinol; N-Methylaspartate; Piperidines; Psychotic Disorders; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Stereotyped Behavior; Zebrafish | 2021 |
Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents.
Topics: Animals; Humans; N-Methylaspartate; Neuroblastoma; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Piperidines; Receptors, sigma; Zebrafish | 2023 |