n-methylaspartate has been researched along with phencyclidine in 217 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 78 (35.94) | 18.7374 |
| 1990's | 107 (49.31) | 18.2507 |
| 2000's | 21 (9.68) | 29.6817 |
| 2010's | 6 (2.76) | 24.3611 |
| 2020's | 5 (2.30) | 2.80 |
| Authors | Studies |
|---|---|
| Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM | 1 |
| Sage, GP; Sethy, VH | 1 |
| Chapman, CD; Howard, S; Marek, P | 1 |
| Cler, JA; Garland, DJ; Hood, WF; Iyengar, S; Mick, SJ; Monahan, JB; Rao, TS; Sun, ET; Vazquez, ML | 1 |
| Holopainen, I; Janáky, R; Oja, SS; Saransaari, P; Varga, V | 1 |
| Balster, RL | 1 |
| Matsuda, Y; Nonaka, H; Nozawa, M; Toki, S; Tsukuda, E; Yoshida, M | 1 |
| Bonhaus, DW; McNamara, JO | 3 |
| French, ED | 1 |
| Adler, LE; Bickford, PC; Freedman, R; Gerhardt, GA; Luntz-Leybman, V; Miller, CL | 1 |
| Koyama, T; Nakamura, F; Ohmori, T; Wang, P; Yamashita, I | 1 |
| Lee, HK; Wang, Y | 1 |
| Dure, LS; Penney, JB; Young, AB | 1 |
| Hönack, D; Löscher, W | 1 |
| Nishikawa, T; Ohi, K; Takahashi, K; Takashima, M | 1 |
| Carter, AJ; Müller, RE | 1 |
| Brent, PJ | 1 |
| Bonhaus, DW; Hosford, DA; McNamara, JO | 1 |
| Dildy-Mayfield, JE; Leslie, SW | 1 |
| Bennett, MV; Lerma, J; Zukin, RS | 1 |
| Millan, MJ | 1 |
| Backhauss, C; Karkoutly, C; Krieglstein, J; Nuglisch, J; Peruche, B; Prehn, JH; Rossberg, C | 1 |
| Duffy, O; Junien, JL; Pascaud, X; Roman, FJ | 1 |
| Abreu, M; Ferkany, J; French, ED; Levenson, S | 1 |
| Balster, RL; Mansbach, RS | 1 |
| Balster, RL; Jortani, SA; Mansbach, RS; Willetts, J | 1 |
| Cler, JA; Contreras, PC; Dilworth, VM; Iyengar, S; Mick, SJ; Monahan, JB; Rao, TS; Wood, PL | 1 |
| Drian, MJ; Kamenka, JM; Pirat, JL; Privat, A | 1 |
| Chai, CY; Kao, MC; Lee, HK; Wang, Y | 1 |
| Geyer, MA; Lehmann-Masten, VD | 1 |
| Ben-Ari, Y; Roisin-Lallemand, MP; Tremblay, E | 1 |
| Fujiwara, M; Fukunaga, R; Kameyama, M; Ninomiya, H; Shimohama, S; Taniguchi, T | 1 |
| Ohno, Y; Warnick, JE | 1 |
| Compton, RP; Hood, WF; Monahan, JB | 1 |
| Bommarito, M; Johnston, MV; McDonald, JW; Silverstein, FS | 1 |
| Anderson, EG; Grigg, JJ | 1 |
| Carter, CJ; Lloyd, KG; Scatton, B; Zivkovic, B | 1 |
| Okamoto, K; Sakai, Y; Sekiguchi, M | 1 |
| Chaki, S; Muramatsu, M; Otomo, S; Usuki-Ito, C | 1 |
| Costa, E; Grayson, DR; Szekely, AM | 1 |
| Dingledine, R; McNamara, D | 1 |
| Boksa, P; Chaudieu, I; Mount, H; Quirion, R | 1 |
| Carlsson, M; Svensson, A | 1 |
| Colpaert, FC; Koek, W | 1 |
| Kozikowski, AP; Pang, YP | 1 |
| Ikin, AF; Kloog, Y; Sokolovsky, M | 1 |
| Johnson, KM; Jones, SM | 2 |
| Baron, BM; Harrison, BL; McDonald, IA; Miller, FP; Palfreyman, MG; Salituro, FG; Schmidt, CJ; Sorensen, SM; White, HS | 1 |
| Jope, RS; Li, X; Ormandy, GC | 1 |
| Cruz, LJ; Gullak, MF; Mena, EE; Olivera, BM; Pagnozzi, MJ; Richter, KE; Rivier, J | 1 |
| Church, J; Lodge, D | 1 |
| Daniell, LC | 1 |
| Colpaert, FC; Koek, W; Woods, JH | 1 |
| Nabeshima, T; Ogita, K; Yoneda, Y | 1 |
| Berger, SP; Markwell, MA; Paul, SM | 1 |
| Boxer, PA; Cordon, JJ; Mann, ME; Marcoux, FW; Rock, DM; Rodolosi, LC; Taylor, CP; Vartanian, MG | 1 |
| Aanonsen, LM; Wilcox, GL | 2 |
| Fagg, GE | 1 |
| Bertolino, M; Costa, E; Mazzetta, J; Vicini, S | 1 |
| Rothman, S | 1 |
| Albuquerque, EX; Ramoa, AS | 1 |
| Johnson, KM; Morter, RS; Snell, LD | 2 |
| Bennett, MV; Kushner, L; Lerma, J; Zukin, RS | 1 |
| DeLander, GE; Wahl, JJ | 1 |
| Bonhaus, DW; McNamara, JO; Skaryak, L; Yeh, GC | 1 |
| Belaidi, M; Kamenka, JM; Lerner-Natoli, M; N'Gouemo, P; Rondouin, G | 1 |
| Bennett, MV; Kushner, L; Lerma, J; Spray, DC; Zukin, RS | 1 |
| Brooker, G; Costa, E; Danysz, W; Wroblewski, JT | 1 |
| Alho, H; Barbaccia, ML; Costa, E; Szekely, AM | 1 |
| Hoffman, PL; Moses, F; Rabe, CS; Tabakoff, B | 1 |
| Balster, RL; Willetts, J | 2 |
| Costa, E; Fadda, E; Lazarewicz, JW; Mazzetta, J; Wroblewski, JT | 1 |
| Gonzales, RA; Moerschbaecher, JM | 1 |
| Rao, TS; Wood, PL | 1 |
| Amrick, CL; Bennett, DA; Bernard, PS; Hutchison, AJ; Liebman, JM; Wilson, DE | 1 |
| Iversen, SD; Oles, RJ; Preston, C; Singh, L; Tricklebank, MD | 1 |
| Miller, RJ; Reynolds, IJ | 1 |
| Jackson, A; Sanger, DJ | 2 |
| Bowe, MA; Martin, D; Nadler, JV | 1 |
| Jacobson, AE; Mattson, MV; Rice, KC; Rogawski, MA; Thurkauf, A; Yamaguchi, S | 1 |
| Johnston, MV; McDonald, JW; Silverstein, FS | 1 |
| Balster, RL; Bobelis, DJ; Willetts, J | 1 |
| Jarvis, MF; Murphy, DE; Williams, M | 1 |
| Frierdich, G; Labruyere, J; Mueller, M; Olney, JW; Price, MT; Salles, KS; Silverman, E | 1 |
| Jacobson, AE; Johnson, KM; Lessor, RA; Rice, KC; Snell, LD; Yi, SJ | 1 |
| Aram, JA; Church, J; Davies, SN; Lodge, D; Martin, D; Millar, JD | 1 |
| Haring, R; Kloog, Y; Sokolovsky, M | 1 |
| Johnson, KM; Snell, LD; Yi, SJ | 2 |
| Champagnat, J; Denavit-Saubié, M; Foutz, AS | 1 |
| Choi, DW; Goldberg, MP; Viseskul, V | 1 |
| Koek, W; Winger, GD; Woods, JH | 1 |
| Pullan, LM | 1 |
| Aizenman, E; Karschin, A; Lipton, SA | 1 |
| Johnson, KM; Snell, LD | 4 |
| Bertin, J; Carter, C; Dupont, R; Duverger, D; Frost, J; Gaudilliere, B; Gotti, B; MacKenzie, ET; Rousseau, J; Scatton, B | 1 |
| Arbilla, S; Benavides, J; Carter, C; Legendre, P; Lloyd, KG; MacKenzie, ET; Noel, F; Thuret, F; Vincent, JD; Zivkovic, B | 1 |
| Chavkin, C; Malouf, AT; Swearengen, E | 1 |
| De Prins, E; Marrannes, R; Wauquier, A; Willems, R | 1 |
| Lodge, D; Martin, D | 1 |
| Koek, W; Ornstein, P; Woods, JH | 1 |
| MacDonald, JF; Miljkovic, Z; Schneiderman, JH | 1 |
| Johnson, KM; Jones, SM; Snell, LD | 2 |
| Johnson, KM; Nichtenhauser, R; Rivier, J; Snell, LD; Vale, W; Zukin, RS; Zukin, SR | 1 |
| Ambar, I; Kloog, Y; Sokolovsky, M | 1 |
| Bockaert, J; Pin, JP; Van-Vliet, BJ | 1 |
| Astier, H; Tapia-Arancibia, L | 1 |
| Berry, SC; Church, J; Lodge, D | 1 |
| Chu, DC; Greenamyre, JT; Maragos, WF; Penney, JB; Young, AB | 1 |
| Blake, J; Church, J; Davies, SN; Jacobson, AE; Lessor, RA; Lodge, D; Rice, KC | 1 |
| Drejer, J; Honoré, T; Nielsen, M; Olverman, HJ; Watkins, JC | 1 |
| Ho, PM; Tang, AH | 1 |
| Johnson, KM; Sacaan, AI; Snell, LD | 1 |
| Fukuda, H; Nagano, N; Ono, H | 1 |
| Lawson, RR; Leander, JD; Ornstein, PL; Zimmerman, DM | 1 |
| Compton, RP; Contreras, PC; Monahan, JB; O'Donohue, TL | 1 |
| Drejer, J; Honoré, T | 1 |
| Henderson, G; Lacey, MG | 1 |
| Iversen, LL; Kemp, JA; Knight, AR; Priestley, T; Wong, EH; Woodruff, GN | 1 |
| Anis, NA; Berry, SC; Lodge, D | 1 |
| Anis, NA; Berry, SC; Burton, NR; Lodge, D | 2 |
| Anis, NA; Lodge, D | 1 |
| Ault, B; DeHaven-Hudkins, DL; Dority, JA; Dung, JS; Earley, WG; Herrmann, JL; Kumar, V; Mallamo, JP; Miller, MS; Subramanyam, C | 1 |
| Cory-Slechta, DA | 2 |
| Aimone, LD; Ault, B; DeHaven-Hudkins, DL; Dority, JA; Earley, WG; Kelly, MD; Kumar, V; Mallamo, JP; Miller, MS; Subramanyam, C | 1 |
| Bowe, MA; Nadler, JV | 1 |
| Bockaert, J; Didier, M; Gonalons, N; Héaulme, M; Pin, JP; Soubrié, P | 1 |
| Ali, SF; Bowyer, JF; Holson, RR; Newport, GD; Slikker, W | 1 |
| French, ED; Wang, T | 1 |
| Johnson, KM; Jones, SM; Sacaan, AI; Snell, LD | 1 |
| Ellison, G | 1 |
| Peeters, BW; Reijmers, LG; Vanderheyden, PM | 1 |
| Ferkany, JW; Karbon, EW; Price, CH; Saab, OH; Sweetnam, PM; Wroblewski, JT | 1 |
| Hirano, M; Hondo, H; Nakahara, T; Nakamura, K; Tashiro, N; Uchimura, H | 1 |
| Cline, P; Mansbridge, JN; Morhenn, VB; Toll, L; Unson, D; Waleh, NS; Zolotorev, A | 1 |
| Pèzzola, A; Popoli, P; Sagratella, S | 1 |
| French, ED; O'Connor, WT; Ungerstedt, U; Wang, T | 1 |
| Kovács, KJ; Larson, AA | 1 |
| Balster, RL; Nicholson, KL; Sanger, DJ | 1 |
| Gao, XM; Tamminga, CA | 1 |
| Hargreaves, RJ; Hill, RG; Iversen, LL | 1 |
| Elman, I; Heresco-Levy, U; Javitt, D | 1 |
| Ohmori, T | 1 |
| Larson, AA; Sun, X | 1 |
| Gruner, R; Lodge, D; Millar, J; Parsons, CG; Rozental, J | 1 |
| Denavit-Saubié, M; Ghilini, G; Salès, N | 1 |
| Jacobsen, P; Klockgether, T; Löschmann, PA; Turski, L | 1 |
| French, ED; Mura, A; Wang, T | 1 |
| Barkai, E; Greene, RW; Grunze, HC; Hasselmo, ME; Hearn, EF; McCarley, RW; Rainnie, DG | 1 |
| de Montigny, C; Debonnel, G | 1 |
| Chen, X; Hurlbert, M; Joseph, DB; Kumar, KN; Michaelis, EK; Michaelis, ML | 1 |
| Black, MA; Durkin, JP; Mealing, GA; Morley, P; Tremblay, R; Whitfield, JF | 1 |
| Carter, C; Fage, D; Klarica, M | 1 |
| Johnson, SW; Wu, YN | 1 |
| Davies, JA; Hu, RQ | 1 |
| Blacker, D; Broberger, C; Hökfelt, T; Ogren, SO | 1 |
| Nishikawa, T; Takahashi, K; Umino, A; Yoshida, Y | 1 |
| Baron, BM; Fadayel, GM; Harrison, BL; Kehne, JH; McCloskey, TC; Murawsky, MK; Nyce, P; Salituro, FG; Schmidt, CJ; Senyah, Y; Siegel, BW; Taylor, VL; van Giersbergen, PL; White, HS | 1 |
| Alagarsamy, S; Johnson, KM; Pappas, T; Phillips, M | 1 |
| Danthi, SN; Hill, RA; Layer, RT; Miller, DD; Shams, G; Tai, H; Uretsky, NJ; Wallace, LJ; Weinstein, DM; Willins, D | 1 |
| Kawahara, T; Kuroki, T; Tashiro, N; Uchimura, H; Yonezawa, Y | 1 |
| d'Arbigny, P; Gourdier, B; Hoizey, G; Lamiable, D; Millart, H; Vistelle, R | 1 |
| Mateu, G; Privat, A; Thibault, J; Vignon, J | 1 |
| Nishikawa, T; Takahashi, K; Umino, A | 1 |
| Dilmore, JG; Johnson, JW | 1 |
| Balster, RL; Jones, HE; Nicholson, KL | 1 |
| Bowen, CA; Gatto, GJ; Grant, KA | 1 |
| Balster, RL; Bowen, SE; Jones, HE; Wiley, JL | 1 |
| Balla, A; Javitt, DC; Lajtha, A; Sershen, H | 1 |
| Arvanov, VL; Wang, RY | 1 |
| Kakigi, T; Maeda, K; Yamamoto, Y | 1 |
| Koek, W | 1 |
| Grant, KA; Green-Jordan, K | 1 |
| Hashim, A; Javitt, DC; Lajtha, A; Sershen, H | 1 |
| Johnson, KM; Kaufmann, JA; Sanchez-Ross, MG; Wang, C | 1 |
| Boireau, A; Bordier, F; Imperato, A; Meunier, M; Monterrat, C | 1 |
| Stanojlović, O; Susić, V; Zivanović, D | 1 |
| Doat, M; Rabin, RA; Winter, JC | 1 |
| Ai, J; Jardemark, KE; Ninan, I; Wang, RY | 1 |
| Carpy, A; Elhallaoui, M; Laguerre, M; Ouazzani, FC | 1 |
| Grant, KA; Jordan, K; Szeliga, KT; Vivian, JA; Waters, CA | 1 |
| Shi, WX; Zhang, XX | 1 |
| Galizio, M; Keith, JR; Mansfield, WJ; Pitts, RC | 1 |
| Jardemark, KE; Ninan, I; Wang, RY | 1 |
| Ogonowski, AA; Smith, JB | 1 |
| Hu, JY; Takigawa, M; Wang, HD | 1 |
| Balster, RL; Wiley, JL | 1 |
| Sun, W; Wessinger, WD | 1 |
| Baker, LE; Brandt, AE; Poling, A; Van Tilburg, TJ | 1 |
| Enomoto, T; Furukawa, H; Hotta, K; Kim, HC; Mouri, A; Murai, R; Nabeshima, T; Nitta, A; Noda, Y; Shin, EJ; Wang, D | 1 |
| Goodman, CB; Harris, C; Lee, E; Oriaku, ET; Soliman, KF; Thomas, M; Williams, Z | 1 |
| Aspromonte, JM; Balla, A; Cooper, TB; Javitt, DC; Sershen, H; Xie, S | 1 |
| Alonso, R; Avenet, P; Bergis, O; Biton, B; Boulay, D; Cohen, C; Coste, A; Dargazanli, G; Desvignes, C; Estenne-Bouhtou, G; George, P; Griebel, G; Lanneau, C; Oury-Donat, F; Pichat, P; Rogacki, N; Scatton, B; Sevrin, M; Steinberg, R; Stemmelin, J; Terranova, JP; Vigé, X | 1 |
| Bac, P; Gressens, P; Maurois, P; Pages, N; Stables, JP; Stanicki, D; Vamecq, J; Vanden Eynde, JJ | 1 |
| Creeley, CE; Farber, NB; Olney, JW; Taylor, GT; Wozniak, DF; Yuede, CM | 1 |
| Jardemark, K; Marcus, MM; Shahid, M; Svensson, TH | 1 |
| Bevins, RA; Murray, JE; Polewan, RJ; Walker, AW | 1 |
| Yavas, E; Young, AM | 1 |
| Amitai, N; Powell, SB; Young, JW | 1 |
| Artigas, F; Castañé, A; Castarlenas, L; Fabius, S; López-Hill, X; Miquel-Rio, L; Santana, N; Scorza, MC; Tarrés-Gatius, M; Vilaró, MT | 1 |
| Alami, A; Alexander, GC; Mattison, DR; Moore, TJ | 1 |
| Abdulzahir, A; Al Obaid, S; Alharbi, SA; Andrew Lin, KY; Ashoori, R; Awuah, KF; Azhdarpoor, A; Badalamenti, N; Basile, A; Benmatti, H; Berkani, M; Berkman, LF; Bontempo, P; Bruno, M; Capasso, L; Castagliuolo, G; Cha, JS; Chang, J; Chen, JT; Chen, WH; Cho, KW; Choi, J; Choi, YJ; Cianciullo, P; Cicio, A; Cousins, M; Di Napoli, M; Emadi, Z; Fakhreddine, B; Go, GW; Grabowski, DC; Hale, B; Ines, A; Jegede, O; Jeon, BH; Khan, MA; Kim, YM; Lakhdari, N; Lam, SS; Lari, AR; Lee, DY; Lee, IH; Lennertz, R; Maresca, V; Marouane, F; Mohammadpour, A; Mousavi Khaneghah, A; Moyo, KM; Napolitano, A; Nguyet, DVH; Park, SJ; Park, YK; Pearce, RA; Perkins, MG; Piacente, S; Renaud, M; Rezania, S; Rhee, GH; Samaei, MR; Siciliano, SD; Smaali, A; Soedono, S; Soltani, NS; Song, H; Song, YR; Taylor, MP; Unger, ES; Varcamonti, M; Wilson, SP; Yousefinejad, S; Zanfardino, A; Zhu, M | 1 |
| Dennis, BH; LeBeau, FEN; Neale, SA; Salt, TE | 1 |
| Kang, UG; Li, G; Xu, S | 1 |
11 review(s) available for n-methylaspartate and phencyclidine
| Article | Year |
|---|---|
The role of receptor binding in drug discovery.
Topics: Animals; Drug Design; Humans; Receptors, Drug | 1993 |
Discriminative stimulus properties of phencyclidine and other NMDA antagonists.
Topics: Animals; Discrimination Learning; Humans; N-Methylaspartate; Phencyclidine; Receptors, sigma | 1991 |
Neuropharmacology of phencyclidine: basic mechanisms and therapeutic potential.
Topics: Animals; Aspartic Acid; Humans; N-Methylaspartate; Nervous System; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1990 |
Anticonvulsant actions of phencyclidine receptor ligands: correlation with N-methylaspartate antagonism in vivo.
Topics: Animals; Anticonvulsants; Aspartic Acid; Humans; Ligands; N-Methylaspartate; Phencyclidine | 1990 |
TCP binding: a tool for studying NMDA receptor-mediated neurotransmission in kindling.
Topics: Animals; Aspartic Acid; Brain; Glycine; Kindling, Neurologic; N-Methylaspartate; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Pharmacologic regulation of the NMDA receptor-ionophore complex.
Topics: Animals; Binding Sites; Biogenic Polyamines; Glycine; Humans; Ion Channels; Ionophores; N-Methylaspartate; Phencyclidine; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1993 |
Neuroprotective NMDA antagonists: the controversy over their potential for adverse effects on cortical neuronal morphology.
Topics: Animals; Cell Survival; Cerebral Cortex; Dextrorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Energy Metabolism; Excitatory Amino Acid Antagonists; Glycine; Gyrus Cinguli; Ketamine; N-Methylaspartate; Neurons; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Vacuoles | 1994 |
[The phencyclidine-N-methyl-D-aspartate theory of schizophrenia: clinical applications].
Topics: Humans; N-Methylaspartate; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 1994 |
Modulation of NMDA and dopaminergic neurotransmissions by sigma ligands: possible implications for the treatment of psychiatric disorders.
Topics: Animals; Central Nervous System; Dopamine; Humans; Mental Disorders; N-Methylaspartate; Neuropeptides; Phencyclidine; Psychotic Disorders; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Receptors, sigma; Steroids; Synaptic Transmission | 1996 |
N-methyl-D-aspartate antagonists and drug discrimination.
Topics: Animals; Discrimination, Psychological; Excitatory Amino Acid Agonists; Humans; N-Methylaspartate; Phencyclidine | 1999 |
Safety and effectiveness of NMDA receptor antagonists for depression: A multidisciplinary review.
Topics: Animals; Depression; Humans; Ketamine; Mammals; N-Methylaspartate; Phencyclidine; Receptors, N-Methyl-D-Aspartate | 2022 |
206 other study(ies) available for n-methylaspartate and phencyclidine
| Article | Year |
|---|---|
Modulation of release of acetylcholine from the striatum by a proposed excitatory amino acid antagonist U-54494A: comparison with known antagonists, diazepam and phenytoin.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Anticonvulsants; Corpus Striatum; Diazepam; Dizocilpine Maleate; In Vitro Techniques; N-Methylaspartate; Phencyclidine; Phenytoin; Potassium; Pyrrolidines; Rats | 1992 |
The effect of phencyclidine and DL-2-amino-5-phosphonovaleric acid on N-methyl-D-aspartic acid induced changes in extracellular concentration of dopamine and DOPAC in the rat neostriatum.
Topics: 2-Amino-5-phosphonovalerate; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Extracellular Space; Kinetics; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Time Factors | 1992 |
Characterization of 3-carboxy-5-phosphono-1,2,3,4-tetrahydroisoquinoline (SC-48981), a potent competitive N-methy-D-aspartate (NMDA) receptor antagonist, in vitro and in vivo.
Topics: Animals; Binding, Competitive; Cerebellum; Cyclic GMP; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Isoquinolines; Male; Mice; N-Methylaspartate; Organophosphorus Compounds; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Tetrahydroisoquinolines | 1992 |
Effect of magnesium on calcium influx activated by glutamate and its agonists in cultured cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Calcium Radioisotopes; Cells, Cultured; Cerebellum; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Nifedipine; Phencyclidine; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Verapamil | 1992 |
The ES-242s, novel N-methyl-D-aspartate antagonists of microbial origin, interact with both the neurotransmitter recognition site and the ion channel domain.
Topics: Animals; Binding, Competitive; Biological Transport; Calcium; Cells, Cultured; Cyclic GMP; Dizocilpine Maleate; Hippocampus; Ion Channels; Kinetics; Mice; N-Methylaspartate; Neurons; Neurotransmitter Agents; Phencyclidine; Pipecolic Acids; Pyrans; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1992 |
Uncompetitive antagonist binding: a biochemical index of activation of the NMDA receptor-coupled ion channel.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Culture Techniques; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1992 |
Competitive NMDA receptor antagonists attenuate phencyclidine-induced excitations of A10 dopamine neurons.
Topics: Action Potentials; Animals; Anticonvulsants; Binding, Competitive; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Male; N-Methylaspartate; Neurons; Phencyclidine; Pipecolic Acids; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical | 1992 |
Phencyclidine and auditory sensory gating in the hippocampus of the rat.
Topics: Acoustic Stimulation; Animals; Auditory Pathways; Benzylamines; Biogenic Monoamines; Electrophysiology; Evoked Potentials; Hippocampus; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sympathomimetics | 1992 |
Effect of phencyclidine on spontaneous and N-methyl-D-aspartate (NMDA)-induced efflux of dopamine from superfused slices of rat striatum.
Topics: Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; In Vitro Techniques; Male; N-Methylaspartate; Perfusion; Phencyclidine; Rats; Rats, Inbred Strains | 1992 |
Electrophysiological interactions between NMDA and phencyclidine/sigma receptor agonists and antagonists in Purkinje neurons in the cerebellum of the rat.
Topics: Animals; Cerebellum; Male; N-Methylaspartate; Oscillometry; Phencyclidine; Purkinje Cells; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1991 |
Excitatory amino acid binding sites in the caudate nucleus and frontal cortex of Huntington's disease.
Topics: Adolescent; Adult; Age Factors; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Binding, Competitive; Caudate Nucleus; Cell Death; Child; Dizocilpine Maleate; Frontal Lobe; Glycine; Humans; Huntington Disease; Ibotenic Acid; Kainic Acid; Middle Aged; N-Methylaspartate; Phencyclidine; Receptors, AMPA; Receptors, Glutamate; Receptors, Glycine; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1991 |
Anticonvulsant and behavioral effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Ataxia; Behavior, Animal; Carbamazepine; Dizocilpine Maleate; Female; Kindling, Neurologic; Motor Activity; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
N-methyl-D-aspartate receptor participates in neuronal transmission of photic information through the retinohypothalamic tract.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arylamine N-Acetyltransferase; Hypothalamus; Light; Male; Melatonin; N-Methylaspartate; Neurons; Phencyclidine; Pineal Gland; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Retina; Suprachiasmatic Nucleus; Synaptic Transmission | 1991 |
Activation of excitatory amino acid receptors cannot alone account for anoxia-induced impairment of protein synthesis in rat hippocampal slices.
Topics: Animals; Aspartic Acid; Carbon Radioisotopes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; Hypoxia; Kainic Acid; Lysine; Male; N-Methylaspartate; Nerve Tissue Proteins; Phenazocine; Phencyclidine; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate | 1991 |
Similar behavioural effects of sigma agonists and PCP-like non-competitive NMDA antagonists in guinea-pigs.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzamides; Dizocilpine Maleate; Dopamine Agents; Dopamine Antagonists; Ergolines; Female; Guanidines; Guinea Pigs; Haloperidol; Ketamine; Male; Motor Activity; N-Methylaspartate; Pentazocine; Phenazocine; Phencyclidine; Quinpirole; Receptors, Dopamine D2; Receptors, Opioid; Receptors, sigma; Remoxipride | 1991 |
A radiohistochemical measure of [3H]TCP binding to the activated NMDA-receptor-gated ion channel in rat brain.
Topics: Animals; Aspartic Acid; Brain; Glycine; Ion Channels; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Mechanism of inhibition of N-methyl-D-aspartate-stimulated increases in free intracellular Ca2+ concentration by ethanol.
Topics: Animals; Brain; Calcium; Dizocilpine Maleate; Ethanol; Glycine; Intracellular Membranes; Ion Channels; N-Methylaspartate; Neurons; Osmolar Concentration; Phencyclidine | 1991 |
Interaction of Mg2+ and phencyclidine in use-dependent block of NMDA channels.
Topics: Animals; Drug Interactions; Ion Channels; Magnesium; N-Methylaspartate; Oocytes; Phencyclidine; Xenopus laevis | 1991 |
Antagonists at the NMDA recognition site and blockers of the associated ion channel induce spontaneous tail-flicks in the rat.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ion Channels; Ketamine; Male; N-Methylaspartate; Organophosphorus Compounds; Phencyclidine; Pipecolic Acids; Piperazines; Piperidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Neuroprotective properties of 5-HT1A receptor agonists in rodent models of focal and global cerebral ischemia.
Topics: Animals; Body Temperature; Brain; Brain Ischemia; Disease Models, Animal; Hypothalamus, Posterior; Ischemic Attack, Transient; Male; Mice; N-Methylaspartate; Phencyclidine; Pyridines; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1991 |
N-methyl-D-aspartate receptor complex modulation by neuropeptide Y and peptide YY in rat hippocampus in vitro.
Topics: Animals; Gastrointestinal Hormones; Hippocampus; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Neuropeptide Y; Norepinephrine; Peptide YY; Peptides; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Effects of competitive N-methyl-D-aspartate antagonists on midbrain dopamine neurons: an electrophysiological and behavioral comparison to phencyclidine.
Topics: Amino Acids; Amphetamine; Animals; Behavior, Animal; Dopamine; Electrophysiology; Limbic System; Male; Mesencephalon; Motor Activity; N-Methylaspartate; Neurons; Nucleus Accumbens; Oxidopamine; Phencyclidine; Pipecolic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Pharmacological specificity of the phencyclidine discriminative stimulus in rats.
Topics: Animals; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Generalization, Psychological; Ligands; Male; N-Methylaspartate; Pentobarbital; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule | 1991 |
NMDA antagonists: lack of antipunishment effect in squirrel monkeys.
Topics: Amino Acids; Animals; Conditioning, Operant; Isoflurophate; Male; Midazolam; N-Methylaspartate; Pentobarbital; Phencyclidine; Piperazines; Punishment; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Saimiri | 1991 |
Contrasting neurochemical interactions of tiletamine, a potent phencyclidine (PCP) receptor ligand, with the N-methyl-D-aspartate-coupled and -uncoupled PCP recognition sites.
Topics: Animals; Behavior, Animal; Binding Sites; Cerebral Cortex; Cyclic GMP; Dizocilpine Maleate; Dopamine; Drug Interactions; Ligands; Male; N-Methylaspartate; Olfactory Pathways; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine; Tiletamine | 1991 |
Non-competitive antagonists of N-methyl-D-aspartate prevent spontaneous neuronal death in primary cultures of embryonic rat cortex.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclohexanes; Cyclohexenes; Dizocilpine Maleate; Embryo, Mammalian; Female; N-Methylaspartate; Neurons; Phencyclidine; Piperidines; Pregnancy; Rats; Rats, Inbred Strains | 1991 |
NMDA antagonists attenuate hypertension induced by carotid clamping in the rostral ventrolateral medulla of rats.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Anticonvulsants; Arterial Occlusive Diseases; Blood Pressure; Carotid Arteries; Carotid Artery Diseases; Cerebral Ventricles; Hypertension; Injections, Intraventricular; Male; Medulla Oblongata; N-Methylaspartate; Neurons; Pain; Phencyclidine; Pressoreceptors; Rats; Rats, Inbred Strains; Reflex; Vagotomy | 1991 |
Spatial and temporal patterning distinguishes the locomotor activating effects of dizocilpine and phencyclidine in rats.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Exploratory Behavior; Haloperidol; Male; Motor Activity; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains | 1991 |
Developmental study of [3H]TCP and [3H]glycine binding sites in the rat hippocampus.
Topics: Aging; Animals; Autoradiography; Hippocampus; In Vitro Techniques; Kinetics; Magnesium; N-Methylaspartate; Nerve Tissue Proteins; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1990 |
[3H]N-[1-(2-thienyl)cyclohexyl]-3,4-piperidine ([3H]TCP) binding in human frontal cortex: decreases in Alzheimer-type dementia.
Topics: Alzheimer Disease; Aspartic Acid; Binding Sites; Frontal Lobe; Glutamates; Glutamic Acid; Humans; Membranes; N-Methylaspartate; Phencyclidine; Reference Values | 1990 |
Selective depression of the segmental polysynaptic reflex by phencyclidine and its analogs in the rat in vitro: interaction with N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Binding Sites; Haloperidol; In Vitro Techniques; Magnesium; Male; Methiothepin; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reflex; Spinal Cord | 1990 |
N-methyl-D-aspartate recognition site ligands modulate activity at the coupled glycine recognition site.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Glutamates; Glutamic Acid; Glycine; Ligands; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines | 1990 |
Effects of hypoxia-ischemia and MK-801 treatment on the binding of a phencyclidine analogue in the developing rat brain.
Topics: Animals; Animals, Newborn; Aspartic Acid; Autoradiography; Binding Sites; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hypoxia; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Tritium | 1990 |
Competitive and noncompetitive N-methyl-D-aspartate antagonists modify hypoxia-induced membrane potential changes and protect rat hippocampal slices from functional failure: a quantitative comparison.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Cell Hypoxia; Cell Survival; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains | 1990 |
Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex.
Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Brain; Cells, Cultured; Drug Interactions; Female; Glycine; Male; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine; Spermine; Spinal Cord | 1990 |
Glycine-insensitive NMDA-sensitive receptor expressed in Xenopus oocytes by guinea pig cerebellar mRNA.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cerebellum; Electric Conductivity; Female; Glycine; Guinea Pigs; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Oocytes; Phencyclidine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1990 |
Differentiation of the active site of minaprine from that of phencyclidine in rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Binding Sites; Hippocampus; Ketamine; Male; Membranes; N-Methylaspartate; Phencyclidine; Piperazines; Piperidines; Potassium Channels; Pyridazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1990 |
Transcriptional program coordination by N-methyl-D-aspartate-sensitive glutamate receptor stimulation in primary cultures of cerebellar neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Cerebellum; DNA-Binding Proteins; Gene Expression; Immunoblotting; N-Methylaspartate; Neurons; Phencyclidine; Piperazines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Transcription Factors; Transcription, Genetic | 1990 |
Dual effect of glycine on NMDA-induced neurotoxicity in rat cortical cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Cerebral Cortex; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Kynurenic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Degeneration; Neurons; Oocytes; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Taurine; Xenopus | 1990 |
Phencyclidine and related compounds evoked [3H]dopamine release from rat mesencephalic cell cultures by a mechanism independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Binding Sites; Cells, Cultured; Dioxolanes; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Guanidines; Mesencephalon; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Phencyclidine; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Sigma Factor; Tritium | 1990 |
The non-competitive NMDA antagonists MK-801 and PCP, as well as the competitive NMDA antagonist SDZ EAA494 (D-CPPene), interact synergistically with clonidine to promote locomotion in monoamine-depleted mice.
Topics: Animals; Atropine; Clonidine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Motor Activity; N-Methylaspartate; Phencyclidine; Piperazines; Receptors, N-Methyl-D-Aspartate | 1990 |
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; Kainic Acid; Kynurenic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Oxadiazoles; Phencyclidine; Pyrrolidinones; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
Structural determinants of affinity for the phencyclidine binding site of the N-methyl-D-aspartate receptor complex: discovery of a rigid phencyclidine analogue of high binding affinity.
Topics: Animals; Aspartic Acid; Computer Graphics; Crystallography; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Models, Molecular; Molecular Conformation; Molecular Structure; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship; X-Ray Diffraction | 1990 |
N-methyl-D-aspartate/phencyclidine receptor complex of rat forebrain: purification and biochemical characterization.
Topics: Animals; Aspartic Acid; Brain; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Glutamates; Glycine; Male; Molecular Weight; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Solubility | 1990 |
Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site.
Topics: Animals; Calcium; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Dibenzocycloalkenimine (MK-801) stimulates phosphoinositide hydrolysis in rat cerebral cortical slices).
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Atropine; Cerebral Cortex; Dizocilpine Maleate; Hydrolysis; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Phencyclidine; Phosphatidylinositols; Prazosin; Rats; Rats, Inbred Strains; Zinc | 1990 |
Conantokin-G: a novel peptide antagonist to the N-methyl-D-aspartic acid (NMDA) receptor.
Topics: Amino Acid Sequence; Animals; Conotoxins; Cyclic GMP; Glutamates; Glycine; In Vitro Techniques; Kainic Acid; Molecular Sequence Data; N-Methylaspartate; Peptides, Cyclic; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 1990 |
The noncompetitive N-methyl-D-aspartate antagonists, MK-801, phencyclidine and ketamine, increase the potency of general anesthetics.
Topics: Anesthesia, General; Anesthetics; Animals; Aspartic Acid; Behavior, Animal; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Ketamine; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Phencyclidine | 1990 |
N-methyl-D-aspartate antagonism and phencyclidine-like activity: a drug discrimination analysis.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Injections, Intraperitoneal; Kainic Acid; Male; Mice; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains | 1990 |
[3H]thienylcyclohexylpiperidine binding activity in brain synaptic membranes treated with Triton X-100.
Topics: Animals; Brain; Detergents; Drug Synergism; Glutamates; Male; N-Methylaspartate; Octoxynol; Phencyclidine; Polyethylene Glycols; Rats; Rats, Inbred Strains; Synaptic Membranes; Tritium | 1990 |
The polyamine synthesis inhibitor alpha-difluoromethylornithine blocks NMDA-induced neurotoxicity.
Topics: Animals; Biogenic Polyamines; Cells, Cultured; Eflornithine; Female; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nervous System Diseases; Neurons; Phencyclidine; Pregnancy; Rats | 1990 |
Comparison of phenytoin with noncompetitive N-methyl-D-aspartate antagonists in a model of focal brain ischemia in rat.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Dizocilpine Maleate; Male; N-Methylaspartate; Phencyclidine; Phenytoin; Rats; Rats, Inbred F344 | 1990 |
Phencyclidine selectively blocks a spinal action of N-methyl-D-aspartate in mice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glutamates; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Norepinephrine; Oxadiazoles; Phencyclidine; Quisqualic Acid; Spinal Cord; Substance P; Tetrazoles; Valine | 1986 |
Phencyclidine and related drugs bind to the activated N-methyl-D-aspartate receptor-channel complex in rat brain membranes.
Topics: Amino Acids; Anesthetics, Dissociative; Animals; Aspartic Acid; Brain; Ion Channels; Male; N-Methylaspartate; Narcotics; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Subcellular Fractions | 1987 |
Phencyclidine and glycine modulate NMDA-activated high conductance cationic channels by acting at different sites.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebellum; Cerebral Cortex; Electric Conductivity; Glycine; Ion Channels; N-Methylaspartate; Neurons; Phencyclidine; Rats | 1988 |
Noncompetitive N-methyl-D-aspartate antagonists affect multiple ionic currents.
Topics: Action Potentials; Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; Ion Channels; Ketamine; N-Methylaspartate; Phencyclidine; Potassium; Rats; Receptors, AMPA; Receptors, Drug; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1988 |
Phencyclidine and some of its analogues have distinct effects on NMDA receptors of rat hippocampal neurons.
Topics: Animals; Aspartic Acid; Electric Conductivity; Hippocampus; Ion Channels; Kinetics; N-Methylaspartate; Neurons; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Structural requirements for activation of the glycine receptor that modulates the N-methyl-D-aspartate operated ion channel.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Glycine; Ion Channels; N-Methylaspartate; Phencyclidine; Rats; Receptors, Glycine; Receptors, Neurotransmitter | 1988 |
N-methyl-D-aspartate activates different channels than do kainate and quisqualate.
Topics: Animals; Aspartic Acid; Brain Chemistry; Electric Conductivity; Female; Ion Channels; Kainic Acid; Magnesium; Male; N-Methylaspartate; Oocytes; Oxadiazoles; Phencyclidine; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1989 |
In vivo characterization of phencyclidine/sigma agonist-mediated inhibition of nociception.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Binding, Competitive; Dibenzocycloheptenes; Dizocilpine Maleate; Male; Mice; N-Methylaspartate; Nociceptors; Phenazocine; Phencyclidine; Receptors, Opioid; Receptors, Opioid, delta; Substance P | 1989 |
Glycine regulation of the N-methyl-D-aspartate receptor-gated ion channel in hippocampal membranes.
Topics: Allosteric Regulation; Animals; Aspartic Acid; Cell Membrane; Glutamates; Glycine; Hippocampus; In Vitro Techniques; Ion Channels; Kinetics; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
[Excitotoxic damage of the hippocampus in the rat: involvement of N-methyl-D-aspartate receptors].
Topics: Animals; Aspartic Acid; Hippocampus; Illicit Drugs; Kainic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains | 1989 |
mRNA from NCB-20 cells encodes the N-methyl-D-aspartate/phencyclidine receptor: a Xenopus oocyte expression study.
Topics: Animals; Aspartic Acid; Brain; Cell Line; Evoked Potentials; Female; Hybrid Cells; In Vitro Techniques; N-Methylaspartate; Neuroblastoma; Oocytes; Phencyclidine; Protein Biosynthesis; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; RNA, Messenger; Xenopus | 1989 |
Modulation of glutamate receptors by phencyclidine and glycine in the rat cerebellum: cGMP increase in vivo.
Topics: Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Brain; Cerebellum; Cyclic GMP; Glycine; Injections, Intraventricular; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
In primary cultures of cerebellar granule cells the activation of N-methyl-D-aspartate-sensitive glutamate receptors induces c-fos mRNA expression.
Topics: Animals; Aspartic Acid; Blotting, Northern; Calcium; Cells, Cultured; Cerebellum; Gene Expression Regulation; Glutamates; Glycine; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Oxadiazoles; Phencyclidine; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Transcription, Genetic | 1989 |
N-methyl-D-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Ethanol; Glycine; Granulocytes; N-Methylaspartate; Osmolar Concentration; Phencyclidine; Picrotoxin | 1989 |
Pentobarbital-like discriminative stimulus effects of N-methyl-D-aspartate antagonists.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Flumazenil; Generalization, Psychological; Male; N-Methylaspartate; Pentobarbital; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Glycine and D-serine act as positive modulators of signal transduction at N-methyl-D-aspartate sensitive glutamate receptors in cultured cerebellar granule cells.
Topics: Animals; Aspartic Acid; Calcium; Calcium Radioisotopes; Cells, Cultured; Cerebellum; Glycine; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Serine; Signal Transduction; Strychnine | 1989 |
A phencyclidine recognition site is associated with N-methyl-D-aspartate inhibition of carbachol-stimulated phosphoinositide hydrolysis in rat cortical slices.
Topics: Animals; Aspartic Acid; Carbachol; Cerebral Cortex; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Phencyclidine; Phosphatidylinositols; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1989 |
NMDA-coupled and uncoupled forms of the PCP receptor: preliminary in vivo evidence for PCP receptor subtypes.
Topics: Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Harmaline; Ketamine; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Reference Values | 1989 |
Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-methyl-D-aspartate receptors.
Topics: Animals; Anticonvulsants; Aspartic Acid; Conflict, Psychological; Discrimination Learning; Male; Mice; Mice, Inbred DBA; Motor Activity; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Binding, Competitive; Dibenzocycloheptenes; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ketamine; Male; Motor Activity; N-Methylaspartate; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1989 |
Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines.
Topics: Acetamides; Animals; Aspartic Acid; Brain; Calcium; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glycine; In Vitro Techniques; Ketamine; Kinetics; N-Methylaspartate; Phencyclidine; Piperidines; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Conditioned taste aversions induced by phencyclidine and other antagonists of N-methyl-D-aspartate.
Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Avoidance Learning; Conditioning, Operant; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Taste | 1989 |
A grease-gap method for studying the excitatory amino acid pharmacology of CA1 hippocampal pyramidal cells.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Electrophysiology; Female; Glutamates; Hippocampus; Ibotenic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Phencyclidine; Rats; Rats, Inbred Strains; Valine | 1989 |
Effects of amygdaloid kindling on NMDA receptor function and regulation.
Topics: Amygdala; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Glycine; Hippocampus; Kindling, Neurologic; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Effects of phencyclidine and other N-methyl-D-aspartate antagonists on the schedule-controlled behavior of rats.
Topics: Animals; Aspartic Acid; Conditioning, Psychological; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Piperazines; Piperidines; Punishment; Rats; Rats, Inbred Strains; Reinforcement Schedule; Stereoisomerism | 1989 |
Anticonvulsant activities of 1-phenylcyclohexylamine and its conformationally restricted analog 1,1-pentamethylenetetrahydroisoquinoline.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Cyclohexylamines; Isoquinolines; Male; Mice; Motor Activity; N-Methylaspartate; Phencyclidine; Seizures; Tetrahydroisoquinolines | 1989 |
Neuroprotective effects of MK-801, TCP, PCP and CPP against N-methyl-D-aspartate induced neurotoxicity in an in vivo perinatal rat model.
Topics: Animals; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Female; Male; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains | 1989 |
Drug discrimination based on the competitive N-methyl-D-aspartate antagonist, NPC 12626.
Topics: Amino Acids; Animals; Aspartic Acid; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; N-Methylaspartate; Pentobarbital; Phencyclidine; Rats; Rats, Inbred Strains | 1989 |
Quantitative autoradiographic localization of NMDA receptors in rat brain using [3H]CPP: comparison with [3H]TCP binding sites.
Topics: Animals; Aspartic Acid; Autoradiography; Brain; Brain Chemistry; In Vitro Techniques; Ligands; Male; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.
Topics: Animals; Aspartic Acid; Enkephalins; Hot Temperature; Kainic Acid; Male; Mice; N-Methylaspartate; Narcotics; Nociceptors; Oxadiazoles; Pain; Phencyclidine; Phentolamine; Quisqualic Acid; Receptors, Opioid; Receptors, sigma; Spinal Cord | 1987 |
Anti-parkinsonian agents are phencyclidine agonists and N-methyl-aspartate antagonists.
Topics: Antiparkinson Agents; Aspartic Acid; Binding, Competitive; In Vitro Techniques; N-Methylaspartate; Phencyclidine; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1987 |
Phencyclidine (PCP)-like inhibition of N-methyl-D-aspartate-evoked striatal acetylcholine release, H-TCP binding and synaptosomal dopamine uptake by metaphit, a proposed PCP receptor acylator.
Topics: Acetylcholine; Acylation; Animals; Aspartic Acid; Corpus Striatum; Dopamine; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine; Synaptosomes; Tritium; Tritolyl Phosphates | 1987 |
Differences in results from in vivo and in vitro studies on the use-dependency of N-methylaspartate antagonism by MK-801 and other phencyclidine receptor ligands.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Ketamine; N-Methylaspartate; Phencyclidine; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine; Spinal Cord; Substance-Related Disorders | 1988 |
Kinetic characterization of the phencyclidine-N-methyl-D-aspartate receptor interaction: evidence for a steric blockade of the channel.
Topics: Animals; Aspartic Acid; Cell Membrane; Cerebral Cortex; Kinetics; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1988 |
Linkage between phencyclidine (PCP) and N-methyl-D-aspartate (NMDA) receptors in the cerebellum.
Topics: Animals; Aspartic Acid; Cerebellum; Cerebral Cortex; In Vitro Techniques; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1988 |
N-methyl-D-aspartate (NMDA) receptors control respiratory off-switch in cat.
Topics: Action Potentials; Animals; Aspartic Acid; Cats; Dibenzocycloheptenes; Dizocilpine Maleate; Iontophoresis; Ketamine; N-Methylaspartate; Oxadiazoles; Phencyclidine; Phrenic Nerve; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Respiration; Respiratory Center | 1988 |
Phencyclidine receptor ligands attenuate cortical neuronal injury after N-methyl-D-aspartate exposure or hypoxia.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; L-Lactate Dehydrogenase; Ligands; Mice; N-Methylaspartate; Neurons; Oxygen; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1988 |
MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.
Topics: Anesthesia; Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Catalepsy; Columbidae; Dibenzocycloheptenes; Discrimination Learning; Dizocilpine Maleate; Ketamine; Macaca mulatta; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Self Administration; Synaptic Transmission | 1988 |
Receptor specific inhibition of N-methyl-D-aspartate stimulated 22Na flux from rat hippocampal slices by phencyclidine and other drugs.
Topics: Animals; Aspartic Acid; Behavior, Animal; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Sodium Radioisotopes | 1988 |
The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro.
Topics: Animals; Aspartic Acid; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Interactions; Electrophysiology; Kainic Acid; N-Methylaspartate; Osmolar Concentration; Phencyclidine; Receptors, Amino Acid; Receptors, Cell Surface | 1988 |
Cycloleucine competitively antagonizes the strychnine-insensitive glycine receptor.
Topics: Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Cycloleucine; Glycine; In Vitro Techniques; Male; N-Methylaspartate; Phencyclidine; Rats; Receptors, Glycine; Receptors, Neurotransmitter; Strychnine | 1988 |
N-methyl-D-aspartate receptor regulation of uncompetitive antagonist binding in rat brain membranes: kinetic analysis.
Topics: Animals; Aspartic Acid; Brain; Glycine; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cats; Female; Male; Models, Cardiovascular; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Vasoconstriction | 1988 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cells, Cultured; Cerebellum; Corpus Striatum; Cyclic GMP; Dopamine; Harmaline; In Vitro Techniques; Mice; N-Methylaspartate; Phencyclidine; Piperazines; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1988 |
Comparison of the actions of phencyclidine and sigma ligands on CA1 hippocampal pyramidal neurons in the rat.
Topics: Action Potentials; Animals; Aspartic Acid; Guanidines; Hippocampus; Male; N-Methylaspartate; Neurons; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1988 |
Evidence for a role of the N-methyl-D-aspartate (NMDA) receptor in cortical spreading depression in the rat.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Cortical Spreading Depression; Diazepam; Dibenzocycloheptenes; Dizocilpine Maleate; Ketamine; Male; N-Methylaspartate; Phencyclidine; Phenytoin; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Phencyclidine receptors and N-methyl-D-aspartate antagonism: electrophysiologic data correlates with known behaviours.
Topics: Anesthetics, Dissociative; Animals; Anura; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Electrophysiology; Ketamine; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Spinal Cord | 1988 |
Antagonism of N-methyl-D-aspartate-induced transmitter release in the rat striatum by phencyclidine-like drugs and its relationship to turning behavior.
Topics: Acetylcholine; Amphetamine; Animals; Apomorphine; Aspartic Acid; Benzomorphans; Chlorpromazine; Clozapine; Corpus Striatum; Cyclazocine; Dioxolanes; Dopamine; Haloperidol; Ketamine; Male; Mathematics; Motor Activity; N-Methylaspartate; Phencyclidine; Posture; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
Characterization of the inhibition of excitatory amino acid-induced neurotransmitter release in the rat striatum by phencyclidine-like drugs.
Topics: Animals; Aspartic Acid; Corpus Striatum; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Kainic Acid; Magnesium; Male; N-Methylaspartate; Neurotransmitter Agents; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1986 |
Phencyclidine-like behavioral effects in pigeons induced by systemic administration of the excitatory amino acid antagonist, 2-amino-5-phosphonovalerate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Behavior, Animal; Catalepsy; Columbidae; Dose-Response Relationship, Drug; Injections, Intraventricular; N-Methylaspartate; Phencyclidine; Stereotyped Behavior; Valine | 1986 |
Excitatory amino acids and regenerative activity in cultured neurons.
Topics: Animals; Aspartic Acid; Cells, Cultured; Electric Conductivity; Ketamine; Membrane Potentials; N-Methylaspartate; Neurons; Neurotransmitter Agents; Phencyclidine; Spinal Cord | 1986 |
Phencyclidine selectively inhibits N-methyl-D-aspartate-induced hippocampal [3H]norepinephrine release.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Structure-Activity Relationship; Valine | 1987 |
An endogenous ligand of the brain sigma/PCP receptor antagonizes NMDA-induced neurotransmitter release.
Topics: Acetylcholine; Animals; Aspartic Acid; Cattle; Corpus Striatum; Dopamine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neurotransmitter Agents; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine; Tissue Extracts | 1987 |
Inhibition of N-methyl-D-aspartate-induced hippocampal [3H]norepinephrine release by phencyclidine is dependent on potassium concentration.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Hippocampus; In Vitro Techniques; Magnesium Sulfate; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Potassium; Rats; Rats, Inbred Strains; Valine | 1987 |
Solubilization of rat brain phencyclidine receptors in an active binding form that is sensitive to N-methyl-D-aspartate receptor ligands.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Brain Chemistry; Cell Membrane; Cholic Acid; Cholic Acids; Detergents; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Solubility; Valine | 1988 |
NMDA- and kainate-evoked GABA release from striatal neurones differentiated in primary culture: differential blocking by phencyclidine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Corpus Striatum; gamma-Aminobutyric Acid; Kainic Acid; Mice; N-Methylaspartate; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Glutamate stimulates somatostatin release from diencephalic neurons in primary culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Diencephalon; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Oxadiazoles; Phencyclidine; Potassium; Quisqualic Acid; Rats; Somatostatin; Tetrodotoxin; Valine; Veratridine | 1988 |
Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Dextrorphan; Ketamine; Levorphanol; Morphinans; N-Methylaspartate; Neurons; Phencyclidine; Rats; Receptors, Opioid; Receptors, sigma; Spinal Cord | 1985 |
High correlation between the localization of [3H]TCP binding and NMDA receptors.
Topics: Animals; Aspartic Acid; Autoradiography; Brain; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1986 |
Is Metaphit a phencyclidine antagonist? Studies with ketamine, phencyclidine and N-methylaspartate.
Topics: Action Potentials; Animals; Aspartic Acid; Depression, Chemical; Drug Interactions; Kainic Acid; Ketamine; N-Methylaspartate; Neurons; Oxadiazoles; Phencyclidine; Quisqualic Acid; Rats; Receptors, Opioid; Receptors, sigma; Spinal Cord | 1986 |
Molecular target size of NMDA antagonist binding sites.
Topics: Animals; Aspartic Acid; Cerebral Cortex; In Vitro Techniques; Ligands; Molecular Weight; N-Methylaspartate; Phencyclidine; Pyrazines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Both competitive and non-competitive antagonists of N-methyl-D-aspartic acid disrupt brightness discrimination in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Light; Male; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred F344 | 1988 |
Equilibrium analysis of [3H]TCP binding: effects of glycine, magnesium and N-methyl-D-aspartate agonists.
Topics: Animals; Aspartic Acid; Binding, Competitive; Cerebral Cortex; Dialysis; Glycine; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Synaptosomes | 1988 |
Inhibitory effect of phencyclidine on rat spinal reflexes.
Topics: Animals; Aspartic Acid; Depression, Chemical; Electric Stimulation; Injections, Intravenous; Male; Motor Neurons; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Reflex; Reflex, Monosynaptic | 1988 |
The discriminative stimulus effects of N-methyl-D-aspartate antagonists in phencyclidine-trained rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Discrimination, Psychological; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Methohexital; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Time Factors | 1988 |
Turning behavior induced by phencyclidine: relationship to antagonism of N-methyl-D-aspartate in the rat striatum.
Topics: Acetylcholine; Animals; Aspartic Acid; Corpus Striatum; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Structure-Activity Relationship | 1986 |
Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release.
Topics: Animals; Aspartic Acid; Catecholamines; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; In Vitro Techniques; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats | 1988 |
N-methyl-D-aspartic acid-induced lethality in mice: selective antagonism by phencyclidine-like drugs.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Male; Mice; N-Methylaspartate; Phencyclidine; Rats; Structure-Activity Relationship | 1988 |
The N-methyl-D-aspartate antagonist, 2-amino-7-phosphonoheptanoate, produces phencyclidine-like behavioral effects in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1987 |
Phencyclidine analogues inhibit NMDA-stimulated [3H]GABA release from cultured cortex neurons.
Topics: Animals; Aspartic Acid; Binding, Competitive; Cerebral Cortex; gamma-Aminobutyric Acid; In Vitro Techniques; N-Methylaspartate; Neurons; Phencyclidine; Rats | 1987 |
Glycine potentiates N-methyl-D-aspartate-induced [3H]TCP binding to rat cortical membranes.
Topics: Animals; Aspartic Acid; Cell Membrane; Cerebral Cortex; Drug Synergism; Electric Stimulation; Glycine; In Vitro Techniques; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains | 1987 |
Actions of phencyclidine on rat locus coeruleus neurones in vitro.
Topics: Action Potentials; Animals; Aspartic Acid; Cell Count; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Evoked Potentials; Locus Coeruleus; Male; Membrane Potentials; N-Methylaspartate; Neurons; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Stereoisomerism; Time Factors | 1986 |
The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.
Topics: Animals; Anticonvulsants; Aspartic Acid; Binding Sites; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Ketamine; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains | 1986 |
The effect of the dioxolanes on amino acid induced excitation in the mammalian spinal cord.
Topics: Animals; Aspartic Acid; Cats; Dioxolanes; Dioxoles; Kainic Acid; Ketamine; N-Methylaspartate; Oxadiazoles; Phencyclidine; Quisqualic Acid; Rats; Species Specificity; Spinal Cord; Stereoisomerism; Structure-Activity Relationship | 1984 |
The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate.
Topics: Acetylcholine; Animals; Aspartic Acid; Cats; Female; In Vitro Techniques; Ketamine; Male; N-Methylaspartate; Neurons; Phencyclidine; Rats; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synapses | 1983 |
Stereoselective effects of two phencyclidine derivatives on N-methylaspartate excitation of spinal neurones in the cat and rat.
Topics: Action Potentials; Animals; Aspartic Acid; Cats; Injections, Intravenous; N-Methylaspartate; Phencyclidine; Rats; Spinal Nerves; Stereoisomerism | 1983 |
Effects of phencyclidine on excitatory amino acid activation of spinal interneurones in the cat.
Topics: Amino Acids; Animals; Aspartic Acid; Cats; Drug Interactions; Interneurons; N-Methylaspartate; Phencyclidine; Spinal Cord | 1982 |
Identification, synthesis, and characterization of a unique class of N-methyl-D-aspartate antagonists. The 6,11-ethanobenzo[b]quinolizinium cation.
Topics: Animals; Binding Sites; Ion Channels; Male; Mice; N-Methylaspartate; Neuroprotective Agents; Phencyclidine; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1994 |
MK-801 subsensitivity following postweaning lead exposure.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Lead; Male; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Weaning | 1995 |
Novel benzo[b]quinolizinium cations as uncompetitive N-methyl-D-aspartic acid (NMDA) antagonists: the relationship between log D and agonist independent (closed) NMDA channel block.
Topics: Animals; Binding Sites; Cations; Cells, Cultured; Dizocilpine Maleate; Female; In Vitro Techniques; Mice; N-Methylaspartate; Oocytes; Phencyclidine; Quinolizines; Structure-Activity Relationship; Xenopus laevis | 1995 |
Polyamines antagonize N-methyl-D-aspartate-evoked depolarizations, but reduce Mg2+ block.
Topics: Action Potentials; Analysis of Variance; Animals; Binding, Competitive; Chromatography, High Pressure Liquid; Diamines; Drug Interactions; Eflornithine; Female; Hippocampus; Magnesium; Male; N-Methylaspartate; Phencyclidine; Polyamines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Spermine | 1995 |
35 mM K(+)-stimulated 45Ca2+ uptake in cerebellar granule cell cultures mainly results from NMDA receptor activation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding, Competitive; Calcium; Cell Differentiation; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Magnesium; Mice; N-Methylaspartate; Nifedipine; Phencyclidine; Potassium; Receptors, N-Methyl-D-Aspartate | 1993 |
Development of dopamine and N-methyl-D-aspartate systems in rat brain: the effect of prenatal phencyclidine exposure.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Animals, Newborn; Corpus Striatum; Dopamine; Female; Frontal Lobe; Glutamates; Glutamic Acid; Hydroxyindoleacetic Acid; Male; Methamphetamine; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 1993 |
Effects of phencyclidine on spontaneous and excitatory amino acid-induced activity of ventral tegmental dopamine neurons: an extracellular in vitro study.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Dopamine; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurons; Phencyclidine; Rats; Rats, Sprague-Dawley; Tegmentum Mesencephali | 1993 |
Competitive and non-competitive NMDA antagonists induce similar limbic degeneration.
Topics: Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Isoquinolines; Limbic System; N-Methylaspartate; Nerve Degeneration; Phencyclidine; Rats; Time Factors | 1994 |
Changes in prepulse inhibition after local administration of NMDA receptor ligands in the core region of the rat nucleus accumbens.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Hippocampus; Male; N-Methylaspartate; Nucleus Accumbens; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1995 |
The envelope glycoprotein of HIV-1 alters NMDA receptor function.
Topics: Animals; Calcium Channel Blockers; Cells, Cultured; Dizocilpine Maleate; Electrophysiology; HIV Envelope Protein gp120; N-Methylaspartate; Oocytes; Phencyclidine; Pipecolic Acids; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Xenopus | 1993 |
The effect of phencyclidine on the basal and high potassium evoked extracellular GABA levels in the striatum of freely-moving rats: an in vivo microdialysis study.
Topics: Animals; Dizocilpine Maleate; gamma-Aminobutyric Acid; Male; Microdialysis; N-Methylaspartate; Neostriatum; Nomifensine; Phencyclidine; Potassium; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1995 |
Evidence for an NMDA receptor subunit in human keratinocytes and rat cardiocytes.
Topics: Animals; Blotting, Northern; Cells, Cultured; Dizocilpine Maleate; Humans; Keratinocytes; Ligands; Myocardium; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1994 |
Diphenylhydantoin potentiates the EEG and behavioural effects induced by N-methyl-D-aspartate antagonists in rats.
Topics: Animals; Behavior, Animal; Cortical Synchronization; Dizocilpine Maleate; Drug Synergism; Electroencephalography; Male; N-Methylaspartate; Phencyclidine; Phenytoin; Pipecolic Acids; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior | 1994 |
N-methyl-D-aspartic acid biphasically regulates the biochemical and electrophysiological response of A10 dopamine neurons in the ventral tegmental area: in vivo microdialysis and in vitro electrophysiological studies.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Electrophysiology; Extracellular Space; In Vitro Techniques; Male; Microdialysis; N-Methylaspartate; Neurons; Nucleus Accumbens; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tegmentum Mesencephali | 1994 |
Density of NMDA-coupled and uncoupled 1-[1-(2-[3H]thienyl) cyclohexyl]piperidine recognition sites in the brain and spinal cord: differential effects of NMDA agonists and antagonists.
Topics: Animals; Binding Sites; Brain; Brain Chemistry; Dizocilpine Maleate; Glutamic Acid; Glycine; Haloperidol; Male; Mice; N-Methylaspartate; Phencyclidine; Spinal Cord; Tritium | 1994 |
Evaluation of the reinforcing effects of eliprodil in rhesus monkeys and its discriminative stimulus effects in rats.
Topics: Animals; Appetitive Behavior; Brain; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Macaca mulatta; Male; Motivation; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Wistar; Reinforcement Schedule; Self Administration | 1994 |
An increase in NMDA-sensitive [3H]glutamate and [3H]kainate binding in hippocampus 24 hours after PCP.
Topics: Animals; Autoradiography; Hippocampus; Image Processing, Computer-Assisted; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Up-Regulation | 1994 |
[A study on the pharmacological action of phencyclidine].
Topics: Animals; Brain; Dopamine; Dopamine Agents; In Vitro Techniques; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Wistar | 1993 |
MK-801 and phencyclidine act at phencyclidine sites that are not linked to N-methyl-D-aspartate activity to inhibit behavioral sensitization to kainate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Capsaicin; Dizocilpine Maleate; Haloperidol; Kainic Acid; Male; Mice; N-Methylaspartate; Nociceptors; Phencyclidine; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Receptors, sigma; Spinal Cord | 1993 |
Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan).
Topics: Animals; Cells, Cultured; Dextrorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Embryo, Mammalian; gamma-Aminobutyric Acid; Glycine; Hippocampus; Ketamine; Kinetics; Magnesium; Memantine; Membrane Potentials; N-Methylaspartate; Neurons; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Superior Colliculi | 1993 |
Autoradiographic localisation of NMDA binding sites in brainstem cardiorespiratory areas of adult and newborn cats.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Binding Sites; Brain Mapping; Brain Stem; Cats; Illicit Drugs; Membrane Potentials; N-Methylaspartate; Neurons; Phencyclidine; Pons; Receptors, N-Methyl-D-Aspartate; Tritium | 1993 |
The antiparkinsonian agent budipine is an N-methyl-D-aspartate antagonist.
Topics: Amino Acids; Anesthesia; Animals; Antiparkinson Agents; Binding, Competitive; Brain Chemistry; H-Reflex; In Vitro Techniques; Male; Mice; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Reflex; Reflex, Monosynaptic; Seizures; Spinal Cord | 1993 |
MK-801, phencyclidine (PCP), and PCP-like drugs increase burst firing in rat A10 dopamine neurons: comparison to competitive NMDA antagonists.
Topics: Action Potentials; Animals; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Illicit Drugs; Male; N-Methylaspartate; Neurons; Phencyclidine; Pipecolic Acids; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereotaxic Techniques; Tegmentum Mesencephali; Vibrissae | 1993 |
NMDA-dependent modulation of CA1 local circuit inhibition.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dipeptides; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Female; Hippocampus; Histamine H1 Antagonists; Long-Term Potentiation; Male; Membrane Potentials; N-Methylaspartate; Nerve Fibers; Neural Inhibition; Phencyclidine; Rats; Rats, Inbred Strains; Sensitivity and Specificity; Synaptic Transmission | 1996 |
Ethanol-induced inhibition of [3H]thienylcyclohexylpiperidine (TCP) binding to NMDA receptors in brain synaptic membranes and to a purified protein complex.
Topics: Animals; Brain Chemistry; Dizocilpine Maleate; Dopamine Antagonists; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Haloperidol; Illicit Drugs; Kinetics; Male; Membrane Proteins; N-Methylaspartate; Phencyclidine; Protein Binding; Proteins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sensitivity and Specificity; Spermidine; Synaptic Membranes; Tritium | 1996 |
The desglycinyl metabolite of remacemide hydrochloride is neuroprotective in cultured rat cortical neurons.
Topics: Acetamides; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Intracellular Membranes; N-Methylaspartate; Neurons; Neuroprotective Agents; Osmolar Concentration; Phencyclidine; Protein Kinase C; Rats; Rats, Sprague-Dawley | 1996 |
Pharmacology of N-methyl-D-aspartate-evoked [3H]noradrenaline release in adult rat spinal cord.
Topics: Animals; Aspartic Acid; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tritium | 1996 |
Pharmacological characterization of inward current evoked by N-methyl-D-aspartate in dopamine neurons in the rat brain slice.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; In Vitro Techniques; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Sodium; Spermine; Substantia Nigra; Ventral Tegmental Area | 1996 |
The effect of the desglycinyl metabolite of remacemide on cortical wedges prepared from DBA/2 mice.
Topics: Acetamides; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Anticonvulsants; Binding, Competitive; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Female; Ion Channels; Male; Membrane Potentials; Mice; N-Methylaspartate; Phencyclidine; Phenethylamines; Receptors, N-Methyl-D-Aspartate; Reference Values | 1995 |
Cholecystokinin B receptor antagonists enhance the locomotor response to the N-methyl-D-aspartate antagonists phencyclidine and dizocilpine maleate.
Topics: Animals; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Male; Motor Activity; N-Methylaspartate; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Stimulation, Chemical | 1997 |
Evidence for N-methyl-D-aspartate receptor-mediated increase in norepinephrine utilization in the prefrontal cortex of unanesthetized rats.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic Agents; Animals; Binding, Competitive; Consciousness; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Microinjections; N-Methylaspartate; Norepinephrine; Oxidopamine; Phencyclidine; Piperazines; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sympathomimetics; Tritium | 1997 |
Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Calcium Channels; Cells, Cultured; Cerebellum; Cyclic GMP; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Indoles; Ligands; Male; Mice; Mice, Inbred DBA; Motor Activity; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sodium Channels | 1997 |
Postnatal lead exposure and MK-801 sensitivity.
Topics: Analysis of Variance; Animals; Animals, Suckling; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Lead Poisoning; Male; N-Methylaspartate; Neuroprotective Agents; Phencyclidine; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate | 1997 |
Dopamine neurotoxicity in cortical neurons.
Topics: Animals; Catalase; Cell Culture Techniques; Cell Death; Cerebral Cortex; Chelating Agents; Deferoxamine; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Synergism; L-Lactate Dehydrogenase; N-Methylaspartate; Nomifensine; Phencyclidine; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 1997 |
Structure--activity studies for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid receptors: acidic hydroxyphenylalanines.
Topics: Animals; Binding, Competitive; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Isomerism; Models, Chemical; N-Methylaspartate; Phencyclidine; Quinoxalines; Radioligand Assay; Rats; Receptors, AMPA; Structure-Activity Relationship; Tyrosine | 1997 |
Involvement of gamma-aminobutyric acid neurotransmission in phencyclidine-induced dopamine release in the medial prefrontal cortex.
Topics: Animals; Dizocilpine Maleate; Dopamine; Dopamine Uptake Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; GABA Agonists; gamma-Aminobutyric Acid; Male; Muscimol; N-Methylaspartate; Nomifensine; Phencyclidine; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1998 |
Determination of gacyclidine enantiomers in human plasma by gas chromatography-mass spectrometry using selected-ion monitoring.
Topics: Calibration; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; Male; Microchemistry; N-Methylaspartate; Phencyclidine; Quality Control; Sensitivity and Specificity; Solvents; Stereoisomerism | 1997 |
Comparison of glutamate and N-methyl-D-aspartate toxicities on rat mesencephalic primary cell cultures.
Topics: Animals; Cells, Cultured; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Logistic Models; N-Methylaspartate; Neurons; Neuroprotective Agents; Phencyclidine; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1997 |
Characterization of the phencyclidine-induced increase in prefrontal cortical dopamine metabolism in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alanine; Animals; Corpus Striatum; Dopamine; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Hallucinogens; Haloperidol; Injections, Intraventricular; Male; N-Methylaspartate; Neurons, Afferent; Phencyclidine; Prefrontal Cortex; Rats; Rats, Wistar | 1998 |
Open channel block and alteration of N-methyl-D-aspartic acid receptor gating by an analog of phencyclidine.
Topics: Animals; Cells, Cultured; Embryo, Mammalian; Fluorenes; Ion Channel Gating; Kinetics; Models, Chemical; N-Methylaspartate; Patch-Clamp Techniques; Phencyclidine; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
Evaluation of the reinforcing and discriminative stimulus effects of the N-methyl-D-aspartate competitive antagonist NPC 17742 in rhesus monkeys.
Topics: Amino Acids; Animals; Binding, Competitive; Discrimination, Psychological; Excitatory Amino Acid Antagonists; Female; Macaca mulatta; Male; N-Methylaspartate; Phencyclidine; Reinforcement, Psychology; Self Administration | 1997 |
Assessment of the multiple discriminative stimulus effects of ethanol using an ethanol-pentobarbital-water discrimination in rats.
Topics: Animals; Central Nervous System Depressants; Diazepam; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; GABA Modulators; Hypnotics and Sedatives; Indoles; Male; Midazolam; Morphine; N-Methylaspartate; Narcotics; Pentobarbital; Phencyclidine; Pregnanolone; Quinoxalines; Rats; Rats, Long-Evans; Serotonin Receptor Agonists; Water | 1997 |
Phencyclidine- and diazepam-like discriminative stimulus effects of inhalants in mice.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Agonists; Generalization, Psychological; Inhalation Exposure; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Phencyclidine; Solvents; Substance-Related Disorders | 1999 |
A.E. Bennett Research Award. Reversal of phencyclidine-induced effects by glycine and glycine transport inhibitors.
Topics: Animals; Awards and Prizes; Brain; Dopamine; Glycine Agents; Hallucinogens; Male; Microdialysis; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Phencyclidine; Psychiatry; Rats; Rats, Sprague-Dawley; Schizophrenia; Time Factors | 1999 |
Clozapine, but not haloperidol, prevents the functional hyperactivity of N-methyl-D-aspartate receptors in rat cortical neurons induced by subchronic administration of phencyclidine.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipsychotic Agents; Clozapine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Haloperidol; Male; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1999 |
Intra-striatal phencyclidine inhibits N-methyl-D-aspartic acid-stimulated increase in glutamate levels of freely moving rats.
Topics: Animals; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1999 |
Modulation of the ethanol-like discriminative stimulus effects of diazepam and phencyclidine by L-type voltage-gated calcium-channel ligands in rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Central Nervous System Depressants; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Modulators; Isradipine; Ligands; Male; N-Methylaspartate; Nifedipine; Nimodipine; Phencyclidine; Rats; Rats, Long-Evans | 2000 |
Inhibition of striatal dopamine release by glycine and glycyldodecylamide.
Topics: Aminoquinolines; Animals; Corpus Striatum; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Mice; N-Methylaspartate; Neurons; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Subcellular Fractions; Tritium | 2000 |
Mechanisms of N-methyl-D-aspartate-induced apoptosis in phencyclidine-treated cultured forebrain neurons.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Cells, Cultured; N-Methylaspartate; Phencyclidine; Prosencephalon; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 2000 |
Effects of RPR 118723, a novel antagonist at the glycine site of the NMDA receptor, in vitro.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Male; Membranes; Mice; N-Methylaspartate; Phencyclidine; Pyrazines; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Tritium | 2000 |
N-Methyl-D-aspartic acid- and metaphit-induced audiogenic seizures in rat model of seizures.
Topics: Animals; Disease Models, Animal; Electroencephalography; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Wistar; Seizures | 2000 |
Potentiation of DOM-induced stimulus control by non-competitive NMDA antagonists: a link between the glutamatergic and serotonergic hypotheses of schizophrenia.
Topics: Animals; Discrimination Learning; Disease Models, Animal; Dizocilpine Maleate; DOM 2,5-Dimethoxy-4-Methylamphetamine; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Hallucinogens; Ketamine; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred F344; Schizophrenia | 2000 |
Biphasic modulation of NMDA-induced responses in pyramidal cells of the medial prefrontal cortex by Y-931, a potential atypical antipsychotic drug.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipsychotic Agents; Benzodiazepines; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Phencyclidine; Piperazines; Prefrontal Cortex; Pyramidal Cells; Rats | 2001 |
Molecular modeling of noncompetitive antagonists of the NMDA receptor: proposal of a pharmacophore and a description of the interaction mode.
Topics: Binding Sites; Dioxolanes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ketamine; Lipids; Models, Molecular; Molecular Structure; N-Methylaspartate; Nitrogen; Phencyclidine; Piperidines; Quinolines; Receptors, N-Methyl-D-Aspartate; Static Electricity | 2002 |
Characterization of the discriminative stimulus effects of N-methyl- D-aspartate ligands under different ethanol training conditions in the cynomolgus monkey ( Macaca fascicularis).
Topics: Animals; Central Nervous System Depressants; Conditioning, Operant; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Ketamine; Macaca fascicularis; Male; N-Methylaspartate; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Sex Factors | 2002 |
Dendritic glutamate-induced bursting in the prefrontal cortex: further characterization and effects of phencyclidine.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dendrites; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Hallucinogens; Ketamine; Lysine; Male; Membrane Potentials; N-Methylaspartate; Phencyclidine; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses | 2003 |
Repeated spatial acquisition: effects of NMDA antagonists and morphine.
Topics: Analgesics, Opioid; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Phencyclidine; Rats; Rats, Sprague-Dawley; Serial Learning; Space Perception | 2003 |
Olanzapine and clozapine but not haloperidol reverse subchronic phencyclidine-induced functional hyperactivity of N-methyl-D-aspartate receptors in pyramidal cells of the rat medial prefrontal cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Haloperidol; Male; Membrane Potentials; N-Methylaspartate; Olanzapine; Patch-Clamp Techniques; Phencyclidine; Pirenzepine; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2003 |
Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Gallic Acid; Guanidines; Indazoles; Injections, Intraperitoneal; Kynurenic Acid; Molsidomine; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroprusside; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
The blockade by phencyclidine of glutamate-induced intracellular calcium increase in cultured neocortical neurons.
Topics: Animals; Calcium; Cells, Cultured; Chelating Agents; Diagnostic Imaging; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescein; Glutamic Acid; Intracellular Space; Microscopy, Confocal; N-Methylaspartate; Neocortex; Neurons; Phencyclidine; Rats; Rats, Wistar | 2004 |
Effects of modulators of N-methyl-D-aspartate receptor-mediated neurotransmission on diazepam discrimination in rats.
Topics: Amino Acids; Animals; Biguanides; Binding Sites; Conditioning, Operant; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Agonists; Male; N-Methylaspartate; Pentobarbital; Phencyclidine; Piperazines; Quinolones; Quinoxalines; Rats; Rats, Sprague-Dawley; Riluzole | 2004 |
Characterization of the non-competitive antagonist binding site of the NMDA receptor in dark Agouti rats.
Topics: Animals; Binding, Competitive; Brain; Dextromethorphan; Dioxolanes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Ketamine; N-Methylaspartate; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Mutant Strains; Receptors, N-Methyl-D-Aspartate; Scintillation Counting; Tritium | 2004 |
Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) and its metabolic precursor, gamma-butyrolactone (GBL) in rats.
Topics: 4-Butyrolactone; Animals; Discrimination Learning; Dose-Response Relationship, Drug; Ethanol; Generalization, Stimulus; Illicit Drugs; Ketamine; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Sprague-Dawley; Sodium Oxybate | 2005 |
Long-lasting impairment of associative learning is correlated with a dysfunction of N-methyl-D-aspartate-extracellular signaling-regulated kinase signaling in mice after withdrawal from repeated administration of phencyclidine.
Topics: Amygdala; Animals; Conditioning, Psychological; Extracellular Signal-Regulated MAP Kinases; Fear; Hippocampus; Learning Disabilities; MAP Kinase Signaling System; Mice; N-Methylaspartate; Phencyclidine; Substance Withdrawal Syndrome | 2005 |
Effects of NMDA receptor inhibition by phencyclidine on the neuronal differentiation of PC12 cells.
Topics: Analysis of Variance; Animals; Biogenic Amines; Blotting, Western; Cell Differentiation; Cell Survival; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Nerve Growth Factor; Neurites; Neurons; PC12 Cells; Phencyclidine; Protein Binding; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 2006 |
Characterization of interactions between phencyclidine and amphetamine in rodent prefrontal cortex and striatum: implications in NMDA/glycine-site-mediated dopaminergic dysregulation and dopamine transporter function.
Topics: Amphetamine; Animals; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Glycine; Male; Microdialysis; N-Methylaspartate; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 2008 |
Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Discrimination, Psychological; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extracellular Space; Gerbillinae; Glycine; Glycine Plasma Membrane Transport Proteins; Male; Mice; Motor Activity; N-Methylaspartate; Phencyclidine; Recognition, Psychology; Reflex, Startle; Schizophrenia; Stereoisomerism; Swimming | 2008 |
1,2-ethane bis-1-amino-4-benzamidine is active against several brain insult and seizure challenges through anti-NMDA mechanisms targeting the 3H-TCP binding site and antioxidant action.
Topics: Animals; Anticonvulsants; Antioxidants; Benzamidines; Binding Sites; Body Temperature; Brain; Mice; Models, Molecular; Molecular Conformation; Motor Activity; N-Methylaspartate; Neuroprotective Agents; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Seizures | 2010 |
Behavioral consequences of NMDA antagonist-induced neuroapoptosis in the infant mouse brain.
Topics: Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Body Weight; Brain; Conditioning, Classical; Fear; Female; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Phencyclidine; Reflex, Startle | 2010 |
Effects of asenapine on prefrontal N-methyl-D-aspartate receptor-mediated transmission: involvement of dopamine D1 receptors.
Topics: Animals; Antipsychotic Agents; Benzazepines; Dibenzocycloheptenes; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Heterocyclic Compounds, 4 or More Rings; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate | 2010 |
An examination of NMDA receptor contribution to conditioned responding evoked by the conditional stimulus effects of nicotine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Conditioning, Classical; Cyclopentanes; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Mecamylamine; N-Methylaspartate; Nicotine; Phencyclidine; Phenols; Piperazines; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2011 |
N-Methyl-d-aspartate Modulation of Nucleus Accumbens Dopamine Release by Metabotropic Glutamate Receptors: Fast Cyclic Voltammetry Studies in Rat Brain Slices in Vitro.
Topics: Animals; Animals, Newborn; Dihydro-beta-Erythroidine; Dopamine; Dose-Response Relationship, Drug; Electric Stimulation; Electrochemical Techniques; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; In Vitro Techniques; N-Methylaspartate; Nicotinic Antagonists; Nucleus Accumbens; Phencyclidine; Picrotoxin; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 2017 |
Phencyclidine increased while isolation rearing did not affect progressive ratio responding in rats: Investigating potential models of amotivation in schizophrenia.
Topics: Affect; Animals; Animals, Newborn; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Antagonists; Male; Motivation; N-Methylaspartate; Phencyclidine; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Reward; Schizophrenia; Social Isolation | 2019 |
Discrimination of motor and sensorimotor effects of phencyclidine and MK-801: Involvement of GluN2C-containing NMDA receptors in psychosis-like models.
Topics: Animals; Dizocilpine Maleate; GABAergic Neurons; Mice; Mice, Knockout; N-Methylaspartate; Phencyclidine; Psychotic Disorders; Receptors, N-Methyl-D-Aspartate | 2022 |
Topics: Activities of Daily Living; Adult; Air Pollution, Indoor; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antioxidants; Azithromycin; Canada; Carbon; Caregivers; Chlorine; Cohort Studies; Corn Oil; COVID-19 Drug Treatment; Daphnia; Dust; Ecosystem; Electrodes; Environmental Monitoring; Fatty Acids; Female; Flavonoids; Fluorides; Glycosides; Greece; Groundwater; Hippocampus; Home Care Services; Humans; Infant; Inflammation; Iridoids; Lamiaceae; Longitudinal Studies; Male; Medicaid; Memory; Metals, Heavy; Methanol; Mice; Microplastics; Middle Aged; N-Methylaspartate; Neural Networks, Computer; Nitrates; Nitrogen Oxides; Nylons; Obesity; Oleic Acid; Olive Oil; Oxidation-Reduction; Phosphorus; Place Cells; Plant Components, Aerial; Plant Extracts; Plastics; Polyesters; Polyurethanes; Prevalence; Quinic Acid; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Risk Assessment; Sodium Chloride; Soil; Soil Pollutants; Stachys; Staphylococcus aureus; Stearic Acids; Superoxide Dismutase; U937 Cells; United States; Water; Water Pollutants, Chemical; Young Adult | 2021 |
Modulation of circuit oscillations in the rat anterior cingulate cortex (ACC) in vitro by mGlu2 metabotropic glutamate receptors and alleviation of the effects of phencyclidine-induced NMDA-receptor hypofunction.
Topics: Animals; Gyrus Cinguli; Humans; N-Methylaspartate; Phencyclidine; Rats; Receptors, Metabotropic Glutamate | 2023 |
Characteristics of MK-801-induced locomotor sensitization.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; N-Methylaspartate; Phencyclidine; Receptors, N-Methyl-D-Aspartate | 2023 |