n-methylaspartate has been researched along with morphine in 119 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (5.88) | 18.7374 |
| 1990's | 51 (42.86) | 18.2507 |
| 2000's | 34 (28.57) | 29.6817 |
| 2010's | 22 (18.49) | 24.3611 |
| 2020's | 5 (4.20) | 2.80 |
| Authors | Studies |
|---|---|
| Yaksh, TL; Yamamoto, T | 2 |
| Barb, CR; Kraeling, RR; Leshin, LS; Rampacek, GB | 1 |
| Carpenter, DO; Hori, N | 1 |
| Chapman, V; Dickenson, AH | 1 |
| Cory-Slechta, DA; Widzowski, DV | 1 |
| Rasmussen, K | 1 |
| Frey, HH; Voits, M | 1 |
| Antonelli, T; Beani, L; Bianchi, C; Morari, M; Tanganelli, S | 1 |
| Orrego, F; Riveros, N | 1 |
| DeLander, GE; Wahl, JJ | 1 |
| Jacquet, YF; Squires, RF | 1 |
| Jacquet, YF | 1 |
| Frenk, H; Liban, A; Teichberg, VI; Urca, G | 1 |
| Choi, DW; Viseskul, V | 1 |
| Bell, RD; Cicero, TJ; Meyer, ER | 1 |
| Advokat, C; Bertman, L; Prejean, J | 1 |
| Ferreira, SH; Lorenzetti, BB | 1 |
| Bieger, D; Liu, L; Neuman, RS; Nie, L; Wang, YT; Zhang, M | 1 |
| Alhaider, AA; Wilcox, GL | 1 |
| Gerber, G; Rawat, B; Sivilotti, LG; Woolf, CJ | 1 |
| Ahmad, I; Pleuvry, BJ | 1 |
| Kreeger, JS; Larson, AA | 2 |
| Hasegawa, T; Maeda, Y; Nabeshima, T; Yamada, K | 1 |
| Bonavera, JJ; Kalra, PS; Kalra, SP; Sahu, A | 1 |
| Franklin, KB; Olmstead, MC | 2 |
| Larson, AA | 2 |
| Balster, RL; Grech, DM; Willetts, J | 1 |
| Alojado, ME; Kemmotsu, O; Ohta, Y; Yamamura, T | 1 |
| Jeziorski, M; Wolf, ME | 1 |
| Glen, RC; Payne, AW | 1 |
| Ferkany, J; Kolesnikov, YA; Pasternak, GW | 1 |
| Mizuguchi, T; Shimoyama, N; Yamamoto, T | 1 |
| Gay, VL; Mikuma, N; Plant, TM | 1 |
| Belozertseva, I; Bespalov, A; Zvartau, E | 1 |
| Dickenson, AH | 1 |
| Manning, BH; Mayer, DJ | 2 |
| Abumrad, NN; Lang, CH; Meijerink, WJ; Molina, PE | 1 |
| Kreeger, JS; Larson, AA; Yukhananov, RY | 1 |
| Drukarch, B; Leysen, JE; Mulder, AH; Nestby, P; Schoffelmeer, AN; Tjon, GH; Visser, DT | 1 |
| Andersen, S; Dickenson, AH; Ebert, B; Kohn, M; Rahman, W; Reeve, A | 1 |
| Herrera-Marschitz, M; Kasakov, L; Nylander, I; Schramm, M; Terenius, L; Vlaskovska, M; You, ZB | 1 |
| Glick, SD; Maisonneuve, IM; Pearl, SM | 1 |
| Fu, ES; Miguel, R; Scharf, JE | 1 |
| Argiolas, A; Melis, MR; Succu, S | 1 |
| Albrecht, C; Darstein, M; Feuerstein, TJ; Hölter, SM; Knörle, R; López-Francos, L; Spanagel, R | 1 |
| Fallon, MT; O'Neill, B | 1 |
| Nishiyama, T; Weber, E; Yaksh, TL | 1 |
| Manning, BH | 1 |
| Bowen, CA; Gatto, GJ; Grant, KA | 1 |
| Alvarez-Vega, M; Baamonde, A; Gutiérrez, M; Hidalgo, A; Menéndez, L | 1 |
| Davis, AM; Inturrisi, CE | 1 |
| Cutler, DJ; Mason, R; Mundey, MK | 1 |
| Slamberová, R; Vathy, I; Velísek, L | 1 |
| Aghajanian, GK; Jolas, T; Nestler, EJ | 1 |
| Franklin, KB; Leri, F | 1 |
| Aoki, T; Narita, M; Suzuki, T | 1 |
| Atapour, N; Kalantaripour, TP; Niazi, M; Nourpanah, M | 1 |
| Chabot, JG; Coderre, TJ; Dray, A; Fundytus, ME; Henry, JL; Lefebvre, CD; Osborne, MG; Yashpal, K | 1 |
| Slamberová, R; Vathy, I | 1 |
| Argiolas, A; Melis, MR | 1 |
| Tao, PL; Wu, CC; Wu, SC; Yang, CH | 1 |
| Fujimoto, JM; Holmes, BB; Rady, JJ; Tseng, LF | 1 |
| Schoffelmeer, AN; Vanderschuren, LJ; Wardeh, G | 1 |
| Su, CH; Tao, PL; Wu, YH; Yeh, GC | 1 |
| Baamonde, A; Hidalgo, A; Lastra, A; Menéndez, L | 1 |
| Mao, J; Mayer, DJ | 1 |
| Baker, AK; Hoffmann, VL; Meert, TF | 1 |
| King, MA; Nitsche, JF; Pasternak, GW; Pintar, JE; Schuller, AG; Zengh, M | 1 |
| Galizio, M; Keith, JR; Mansfield, WJ; Pitts, RC | 1 |
| Kippin, TE; van der Kooy, D | 1 |
| Davis, AM; Inturrisi, CE; Monaghan, DT; Shimoyama, M; Shimoyama, N | 1 |
| Jacobs, EH; Schoffelmeer, AN; Smit, AB; Wardeh, G | 1 |
| Fujio, M; Kaneko, S; Minami, M; Nakagawa, T; Satoh, M; Suzuki, Y; Yamamoto, R | 1 |
| Djahanguiri, B; Jafari-Sabet, M; Rezayat, M; Rezayof, A; Zarrindast, MR | 1 |
| Baldo, MV; Canteras, NS; Felício, LF; Mota-Ortiz, SR; Sukikara, MH | 1 |
| Joo, DT; Zhao, M | 1 |
| Dykstra, LA; Fischer, BD | 1 |
| Chin, TY; Chueh, SH; Tao, PL | 1 |
| Badaras, R; Ivaskevicius, J; Jovaisa, T; Laurinenas, G; Sipylaite, J; Vosylius, S | 1 |
| Abdollahi, M; Aliahmadi, A; Bayrami, Z; Hashemi, N; Kebriaeezadeh, A; Khorasani, R; Mohammadirad, A; Nikfar, S; Sharifzadeh, M; Vosough, S | 1 |
| Lashgari, R; Motamedi, F; Nazari-Serenjeh, F; Rezayof, A; Zarrindast, MR | 1 |
| Heinmiller, A; Sturgess, JE; Ting-A-Kee, RA; van der Kooy, D; Vargas-Perez, H | 1 |
| Komatsu, T; Kuwahata, H; Orito, T; Sakurada, C; Sakurada, S; Sakurada, T; Tsuzuki, M; Watanabe, C | 1 |
| Cheevers, CV; Donello, JE; Gil, DW | 1 |
| Lomas, LM; Picker, MJ; Terner, JM | 1 |
| Heinmiller, A; Ting-A-Kee, R; van der Kooy, D; Vargas-Perez, H; Yeh, A | 1 |
| Reilly, S; Roman, C | 1 |
| Lin, JY; Lovaglio, J; Reilly, S; Roman, C | 1 |
| Motevasseli, T; Nayer-Nouri, T; Rezayof, A; Zarrindast, MR | 1 |
| Ardjmand, A; Rezayof, A; Zarrindast, MR | 1 |
| Asadi, F; Rezayof, A; Zarrindast, MR | 1 |
| Arthurs, J; Lin, JY; Reilly, S | 1 |
| Halder, S; Khanna, N; Mehta, AK; Sharma, KK; Tandon, OP | 1 |
| Berrocoso, E; Garzón, J; Rodríguez-Muñoz, M; Sánchez-Blázquez, P; Vicente-Sánchez, A | 1 |
| Beresewicz, M; Kawalec, M; Kowalczyk, JE; Lipkowski, AW; Zablocka, B | 1 |
| Gong, N; Hashimoto, K; Ma, AN; Wang, HL; Wang, YC; Wang, YX | 1 |
| Delphi, L; Javadi-Paydar, M; Vousooghi, N; Zarrindast, MR | 1 |
| Chaparro, LE; Gilron, I; Moore, RA; Wiffen, PJ | 1 |
| Chaves, C; Declèves, X; Margaill, I; Potin, S; Scherrmann, JM; Yousif, S | 1 |
| Halder, S; Khanna, N; Mehta, AK; Sharma, KK; Singh, UR; Tandon, OP | 1 |
| Arthurs, J; Reilly, S | 1 |
| Dehpour, AR; Ejtemaei Mehr, S; Haj-Mirzaian, A; Kordjazy, N; Ostadhadi, S | 1 |
| Akbarali, HI; Bowers, MS; Fitting, S; Hauser, KF; Knapp, PE; Marks, WD; Zou, S | 1 |
| Jiang, W; Ma, X; Xu, T; Zhang, X; Zhao, D; Zhao, J; Zhong, W | 1 |
| Ghasemzadeh, Z; Ghazvini, H; Rezayof, A; Zarrindast, MR | 1 |
| Rezayof, A; Sharifi, KA; Torkaman-Boutorabi, A; Zarrindast, MR | 1 |
| Cortés-Montero, E; Garzón, J; Onetti, Y; Rodríguez-Muñoz, M; Sánchez-Blázquez, P | 1 |
| Ahmadian-Moghadam, H; Farahmandfar, M; Khalifeh, S; Nouri Zadeh-Tehrani, S; Sadat-Shirazi, MS; Zarrindast, MR | 1 |
| Dillenburg, M; Fairbanks, C; Finzel, B; Kitto, KF; Peterson, C; Shah, RM; Strom, A; Wagner, CR; Wilcox, G | 1 |
| Fabbrin, S; Girardi, BA; Mello, CF; Rubin, MA; Wendel, AL | 1 |
| Aghaei, I; Bahremand, T; Dehpour, AR; Ejtemaei-Mehr, S; Rahimi, N; Shafaroodi, H; Shayan, M; Zamanian, G | 1 |
| Esmaili-Shahzade-Ali-Akbari, P; Hosseinzadeh, H; Mehri, S | 1 |
| Alaei, H; Amohashemi, E; Reisi, P | 1 |
| Hua, M; Jianwen, S; Jie, Z; Rubing, Y; Shuai, H; Tingting, J; Yongxin, L; Ziyi, W | 1 |
6 review(s) available for n-methylaspartate and morphine
| Article | Year |
|---|---|
Afferent effects on locus coeruleus in opiate withdrawal.
Topics: Afferent Pathways; Animals; Cats; Clonidine; Dizocilpine Maleate; Kynurenic Acid; Locus Coeruleus; Morphine; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems; Substance Withdrawal Syndrome | 1991 |
Neurophysiology of opioid poorly responsive pain.
Topics: Analgesics, Opioid; Animals; Central Nervous System; Clonidine; Dextromethorphan; Dextrorphan; Dynorphins; Humans; Morphine; N-Methylaspartate; Neoplasms; Neurophysiology; Neuroprotective Agents; Pain; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Sympatholytics | 1994 |
Enhanced N-methyl-D-aspartate (NMDA)-induced activity following morphine: sensitivity to sigma and PCP ligands.
Topics: Animals; Behavior, Animal; Drug Synergism; Excitatory Amino Acid Agonists; Morphine; N-Methylaspartate; Receptors, Phencyclidine; Receptors, sigma; Spinal Cord | 1995 |
Yawning: role of hypothalamic paraventricular nitric oxide.
Topics: Animals; Dopamine Agonists; Humans; Morphine; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Oxytocin; Paraventricular Hypothalamic Nucleus; Yawning | 1999 |
Spinal cord neuroplasticity following repeated opioid exposure and its relation to pathological pain.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzamides; Dizocilpine Maleate; Drug Tolerance; Hot Temperature; Humans; Hyperalgesia; Morphine; Multiple Chemical Sensitivity; N-Methylaspartate; Narcotics; Nerve Degeneration; Nerve Tissue Proteins; Neuralgia; Neuronal Plasticity; Nitric Oxide; Phosphorylation; Poly(ADP-ribose) Polymerases; Posterior Horn Cells; Protein Kinase C; Protein Processing, Post-Translational; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, Opioid, mu; Sciatic Nerve; Spinal Cord | 2001 |
Combination pharmacotherapy for the treatment of neuropathic pain in adults.
Topics: Acetaminophen; Adult; Amines; Analgesics; Antidepressive Agents, Tricyclic; Benzodiazepinones; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Humans; Morphine; N-Methylaspartate; Neuralgia; Nortriptyline; Phenylurea Compounds; Pregabalin; Thioctic Acid; Tramadol | 2012 |
2 trial(s) available for n-methylaspartate and morphine
| Article | Year |
|---|---|
Preemptive ketamine decreases postoperative narcotic requirements in patients undergoing abdominal surgery.
Topics: Abdomen; Analgesia, Patient-Controlled; Double-Blind Method; Excitatory Amino Acid Agonists; Female; Humans; Ketamine; Male; Middle Aged; Morphine; N-Methylaspartate; Pain Measurement; Pain, Postoperative; Premedication | 1997 |
Effects of ketamine on precipitated opiate withdrawal.
Topics: Adolescent; Adult; Anesthesia, General; Anesthetics, Dissociative; Cardiovascular System; Data Interpretation, Statistical; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Humans; Hydrocortisone; Infusions, Intravenous; Ketamine; Male; Morphine; N-Methylaspartate; Narcotic Antagonists; Narcotics; Placebos; Prospective Studies; Substance Withdrawal Syndrome; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2006 |
111 other study(ies) available for n-methylaspartate and morphine
| Article | Year |
|---|---|
Studies on the spinal interaction of morphine and the NMDA antagonist MK-801 on the hyperesthesia observed in a rat model of sciatic mononeuropathy.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Drug Interactions; Hot Temperature; Hyperesthesia; Injections, Spinal; Male; Morphine; N-Methylaspartate; Pain; Peripheral Nervous System Diseases; Rats; Rats, Inbred Strains; Sciatic Nerve; Spinal Cord; Time Factors | 1992 |
Central nervous system peptide and amino acid modulation of luteinizing hormone and prolactin secretion in the pig.
Topics: Amino Acids; Animals; Endorphins; Female; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Morphine; N-Methylaspartate; Naloxone; Prolactin; Swine | 1992 |
Neurotransmitter and peptide receptors on medial vestibular nucleus neurons.
Topics: Acetylcholine; Afferent Pathways; Amino Acids; Animals; Atropine; Brain Stem; Curare; Enkephalin, Methionine; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Morphine; N-Methylaspartate; Neurons; Neurotransmitter Agents; Rats; Receptors, Neurotransmitter; Vestibular Nuclei | 1992 |
The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn.
Topics: Afferent Pathways; Animals; Electric Stimulation; Hot Temperature; Injections, Spinal; Kynurenic Acid; Morphine; N-Methylaspartate; Naloxone; Nerve Fibers; Neurons; Pain; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Touch | 1992 |
Comparison of the antinociceptive effects of pre- and posttreatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat.
Topics: Animals; Dizocilpine Maleate; Injections, Spinal; Male; Morphine; N-Methylaspartate; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Time Factors | 1992 |
Low level lead exposure increases sensitivity to the stimulus properties of dopamine D1 and D2 agonists.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Behavior, Animal; Cocaine; Dextroamphetamine; Discrimination Learning; Dizocilpine Maleate; Dopamine Agents; Drug Synergism; Ergolines; Generalization, Psychological; Haloperidol; Lead; Male; Morphine; N-Methylaspartate; Pentobarbital; Quinpirole; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Effect of psychotropic agents on a model of absence epilepsy in rats.
Topics: Animals; Antidepressive Agents; Dextroamphetamine; Electroencephalography; Epilepsy; Female; Levodopa; Male; Memantine; Morphine; N-Methylaspartate; Parasympatholytics; Psychotropic Drugs; Rats; Rats, Inbred Strains | 1991 |
Glutamate antagonists prevent morphine withdrawal in mice and guinea pigs.
Topics: Acetylcholine; Animals; Cerebral Cortex; Dizocilpine Maleate; Drug Implants; Drug Tolerance; Excitatory Amino Acid Antagonists; Glutamates; Guinea Pigs; Kinetics; Mice; Morphine; N-Methylaspartate; Naloxone; Parietal Lobe; Psychotropic Drugs; Substance Withdrawal Syndrome | 1991 |
N-methylaspartate-activated calcium channels in rat brain cortex slices. Effect of calcium channel blockers and of inhibitory and depressant substances.
Topics: Animals; Aspartic Acid; Cadmium; Calcium Channel Blockers; Central Nervous System Depressants; Cerebral Cortex; Cobalt; gamma-Aminobutyric Acid; Ion Channels; Morphine; N-Methylaspartate; Nifedipine; Rats; Tetrodotoxin; Time Factors | 1986 |
Morphine (intracerebroventricular) activates spinal systems to inhibit behavior induced by putative pain neurotransmitters.
Topics: Animals; Aspartic Acid; Behavior, Animal; Dose-Response Relationship, Drug; Male; Methysergide; Mice; Morphine; N-Methylaspartate; Naloxone; Neurotransmitter Agents; Nociceptors; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Receptors, Serotonin; Spinal Cord; Substance P | 1989 |
Excitatory amino acids: role in morphine excitation in rat periaqueductal gray.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Kainic Acid; Male; Morphine; Motor Activity; N-Methylaspartate; Oxadiazoles; Periaqueductal Gray; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
The NMDA receptor: central role in pain inhibition in rat periaqueductal gray.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Analgesia; Animals; Aspartic Acid; Kainic Acid; Male; Morphine; N-Methylaspartate; Oxadiazoles; Pain; Periaqueductal Gray; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Absence of side-effects in the anticonvulsant action of cortically applied antagonists of N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dipeptides; Morphine; N-Methylaspartate; Picrotoxin; Quinoxalines; Rats; Rats, Inbred Strains; Seizures; Strychnine; Valine | 1986 |
Opioids and non-opioid enantiomers selectively attenuate N-methyl-D-aspartate neurotoxicity on cortical neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Indicators and Reagents; Methadone; Mice; Morphine; N-Methylaspartate; Naloxone; Narcotics; Neurons; Stereoisomerism | 1988 |
Characterization and possible opioid modulation of N-methyl-D-aspartic acid induced increases in serum luteinizing hormone levels in the developing male rat.
Topics: Aging; Animals; Aspartic Acid; Endorphins; Gonadotropin-Releasing Hormone; Hypothalamus; Luteinizing Hormone; Morphine; N-Methylaspartate; Naloxone; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains | 1988 |
Intrathecal co-administration of morphine and excitatory amino acid agonists produce differential effects on the tail-flick of intact and spinal rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Catheters, Indwelling; Decerebrate State; Drug Synergism; Injections, Spinal; Male; Morphine; N-Methylaspartate; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Reference Values; Statistics as Topic | 1994 |
Glutamate spinal retrograde sensitization of primary sensory neurons associated with nociception.
Topics: Amino Acid Oxidoreductases; Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Spinal; Male; Morphine; N-Methylaspartate; Neurons, Afferent; Nitric Oxide Synthase; Nociceptors; Pain Measurement; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Spinal Cord; Vasodilator Agents | 1994 |
[Morphine blocked the exitatory amino acid mediated membrane current in ambigual motoneurons of the rat].
Topics: Animals; Medulla Oblongata; Membrane Potentials; Morphine; N-Methylaspartate; Neural Pathways; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Solitary Nucleus | 1995 |
Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Buspirone; Male; Mice; Morphine; N-Methylaspartate; Pain; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Substance P; Synaptic Transmission | 1993 |
Morphine selectively depresses the slowest, NMDA-independent component of C-fibre-evoked synaptic activity in the rat spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; In Vitro Techniques; Morphine; N-Methylaspartate; Naloxone; Rats; Spinal Cord; Synapses | 1995 |
Interactions between opioid drugs and propofol in laboratory models of seizures.
Topics: Analgesics, Opioid; Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Fentanyl; Kainic Acid; Meperidine; Mice; Mice, Inbred Strains; Morphine; N-Methylaspartate; Propofol; Seizures | 1995 |
Altered N-methyl-D-aspartate (NMDA) activity in the mouse spinal cord following morphine is mediated by sigma activity.
Topics: Animals; Behavior, Animal; Haloperidol; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; N-Methylaspartate; Naloxone; Receptors, sigma; Spinal Cord | 1995 |
Neuronal mechanism of the inhibitory effect of calcitonin on N-methyl-D-aspartate-induced aversive behavior.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Calcitonin; Cystamine; GABA Antagonists; Injections, Spinal; Male; Mice; Morphine; N-Methylaspartate; Naloxone; Phentolamine; Pindolol; Piperazines; Propranolol; Receptors, Neurotransmitter; Ritanserin; Serotonin Antagonists; Tropanes | 1995 |
The hypothalamic peptides, beta-endorphin, neuropeptide K and interleukin-1 beta, and the opiate morphine, enhance the excitatory amino acid-induced LH release under the influence of gonadal steroids.
Topics: Animals; beta-Endorphin; Estradiol; Feedback; Female; Interleukin-1; Kinetics; Luteinizing Hormone; Male; Morphine; N-Methylaspartate; Neuropeptides; Ovariectomy; Rats; Tachykinins | 1994 |
Increased N-methyl-D-aspartate (NMDA) activity in the mouse spinal cord following morphine does not mediate opioid withdrawal.
Topics: Analysis of Variance; Animals; Dizocilpine Maleate; Injections, Spinal; Male; Mice; Morphine; N-Methylaspartate; Naloxone; Piperazines; Receptors, N-Methyl-D-Aspartate; Reference Values; Spinal Cord; Stereotyped Behavior; Substance Withdrawal Syndrome | 1994 |
Lesions of the pedunculopontine tegmental nucleus abolish catalepsy and locomotor depression induced by morphine.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Catalepsy; Male; Mesencephalon; Morphine; Motor Activity; Muscle Tonus; N-Methylaspartate; Photic Stimulation; Pons; Rats; Rats, Wistar; Reflex; Stimulation, Chemical | 1994 |
Involvement of NMDA receptors in naloxone-induced contractions of the isolated guinea pig ileum after preincubation with morphine.
Topics: Animals; Electric Stimulation; Glutamic Acid; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; N-Methylaspartate; Naloxone; Receptors, N-Methyl-D-Aspartate | 1994 |
Morphine modulates excitatory amino acid-induced activity in the mouse spinal cord: short-term effects on N-methyl-D-aspartate (NMDA) and long-term effects on kainic acid.
Topics: Analysis of Variance; Animals; Drug Synergism; Injections, Intraperitoneal; Injections, Spinal; Kainic Acid; Male; Mice; Morphine; N-Methylaspartate; Naloxone; Spinal Cord; Stereotyped Behavior; Time Factors | 1994 |
Pharmacological specificity of N-methyl-D-aspartate discrimination in rats.
Topics: Animals; Central Nervous System Stimulants; Conditioning, Operant; Convulsants; Discrimination, Psychological; Dose-Response Relationship, Drug; Generalization, Stimulus; Injections, Intraperitoneal; Male; Morphine; N-Methylaspartate; Narcotics; Parasympathomimetics; Rats; Rats, Sprague-Dawley | 1993 |
The effect of fentanyl and morphine on neurons in the dorsal raphe nucleus in the rat: an in vitro study.
Topics: Animals; Fentanyl; In Vitro Techniques; Morphine; N-Methylaspartate; Neurons; Norepinephrine; Raphe Nuclei; Rats; Rats, Wistar; Supine Position | 1994 |
Coadministration of MK-801 with amphetamine, cocaine or morphine prevents rather than transiently masks the development of behavioral sensitization.
Topics: Amphetamine; Analysis of Variance; Animals; Cocaine; Dizocilpine Maleate; Drug Interactions; Male; Morphine; Motor Activity; N-Methylaspartate; Rats; Rats, Sprague-Dawley | 1993 |
Lesions of the pedunculopontine tegmental nucleus block drug-induced reinforcement but not amphetamine-induced locomotion.
Topics: Amphetamine; Analysis of Variance; Animals; Brain Mapping; Conditioning, Operant; Diazepam; Infusions, Parenteral; Male; Morphine; Motor Activity; N-Methylaspartate; Pons; Rats; Rats, Wistar; Reference Values; Reinforcement, Psychology; Seizures; Tegmentum Mesencephali | 1994 |
Molecular recognition using a binary genetic search algorithm.
Topics: Algorithms; Amino Acid Sequence; Carbohydrate Sequence; Carbolines; Deoxyribose; Drug Design; Electrochemistry; Enkephalin, Leucine; gamma-Aminobutyric Acid; Maltose; Models, Genetic; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Morphine; N-Methylaspartate; Peptides, Cyclic; Receptors, GABA-A; Selection, Genetic; Trimethoprim | 1993 |
Blockade of mu and kappa 1 opioid analgesic tolerance by NPC17742, a novel NMDA antagonist.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acids; Analgesics; Animals; Drug Tolerance; Mice; Mice, Inbred Strains; Morphine; N-Methylaspartate; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1993 |
The effects of morphine, MK-801, an NMDA antagonist, and CP-96,345, an NK1 antagonist, on the hyperesthesia evoked by carageenan injection in the rat paw.
Topics: Animals; Biphenyl Compounds; Carrageenan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Hyperesthesia; Injections, Spinal; Male; Morphine; N-Methylaspartate; Neurokinin B; Rats; Rats, Sprague-Dawley | 1993 |
Remote and chronic access to the third cerebral ventricle of the unrestrained prepubertal rhesus monkey.
Topics: Aging; Animals; Cerebral Ventricles; Gonadotropin-Releasing Hormone; Immobilization; Macaca mulatta; Male; Methods; Morphine; N-Methylaspartate; Radioimmunoassay | 1993 |
Behavioral effects of MK-801 in morphine-dependent and non-dependent mice.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Morphine; Morphine Dependence; Motor Activity; N-Methylaspartate; Naloxone; Narcotic Antagonists; Substance Withdrawal Syndrome | 1996 |
The central nucleus of the amygdala contributes to the production of morphine antinociception in the rat tail-flick test.
Topics: Amygdala; Animals; Dose-Response Relationship, Drug; Hot Temperature; Lidocaine; Male; Morphine; N-Methylaspartate; Nociceptors; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Tail | 1995 |
The central nucleus of the amygdala contributes to the production of morphine antinociception in the formalin test.
Topics: Amygdala; Analgesics, Opioid; Animals; Brain Mapping; Formaldehyde; Hindlimb; Injections; Male; Morphine; N-Methylaspartate; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
Contribution of excitatory amino acids to morphine-induced metabolic alterations.
Topics: Animals; Excitatory Amino Acids; Glucose; Hormones; Injections, Intraventricular; Liver Glycogen; Male; Morphine; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Intermittent morphine treatment causes long-term desensitization of functional dopamine D2 receptors in rat striatum.
Topics: Acetylcholine; Animals; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Morphine; N-Methylaspartate; Narcotics; Rats; Rats, Wistar; Receptors, Dopamine D2; Sulpiride | 1995 |
The opioid ketobemidone has a NMDA blocking effect.
Topics: Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Evoked Potentials; Injections, Spinal; Meperidine; Morphine; N-Methylaspartate; Nerve Fibers; Rats; Spinal Cord | 1996 |
Opioid effects on 45Ca2+ uptake and glutamate release in rat cerebral cortex in primary culture.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Biological Transport; Calcium Radioisotopes; Cells, Cultured; Cerebral Cortex; Dynorphins; Excitatory Amino Acid Agonists; Female; Fetus; Glutamic Acid; Homeostasis; Membrane Potentials; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Oligopeptides; Potassium; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1997 |
Evidence for roles of kappa-opioid and NMDA receptors in the mechanism of action of ibogaine.
Topics: Animals; Corpus Striatum; Dopamine; Female; Ibogaine; Morphine; Motor Activity; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Self Administration; Substance-Related Disorders | 1997 |
Prevention by morphine of N-methyl-D-aspartic acid-induced penile erection and yawning: involvement of nitric oxide.
Topics: Animals; Behavior, Animal; Benzeneacetamides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Microdialysis; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Narcotics; Nitric Oxide; Paraventricular Hypothalamic Nucleus; Penile Erection; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Yawning | 1997 |
Release and accumulation of neurotransmitters in the rat brain: acute effects of ethanol in vitro and effects of long-term voluntary ethanol intake.
Topics: Acetylcholine; Alcoholism; Animals; Brain; Caudate Nucleus; Ethanol; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Male; Morphine; N-Methylaspartate; Neurotransmitter Agents; Putamen; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1998 |
Substitution of another opioid for morphine. Opioid toxicity should be managed initially by decreasing the opioid dose.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Humans; Ketamine; Morphine; N-Methylaspartate; Pain; Practice Guidelines as Topic | 1998 |
Effects of intrathecal NMDA and non-NMDA antagonists on acute thermal nociception and their interaction with morphine.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesia; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Hot Temperature; Morphine; N-Methylaspartate; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1998 |
A lateralized deficit in morphine antinociception after unilateral inactivation of the central amygdala.
Topics: Afferent Pathways; Amygdala; Animals; Behavior, Animal; Disinfectants; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fear; Formaldehyde; GABA Agonists; Hindlimb; Hyperalgesia; Locomotion; Male; Morphine; Muscimol; N-Methylaspartate; Narcotics; Nociceptors; Pain; Rats; Rats, Sprague-Dawley | 1998 |
Assessment of the multiple discriminative stimulus effects of ethanol using an ethanol-pentobarbital-water discrimination in rats.
Topics: Animals; Central Nervous System Depressants; Diazepam; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; GABA Modulators; Hypnotics and Sedatives; Indoles; Male; Midazolam; Morphine; N-Methylaspartate; Narcotics; Pentobarbital; Phencyclidine; Pregnanolone; Quinoxalines; Rats; Rats, Long-Evans; Serotonin Receptor Agonists; Water | 1997 |
Comparison of the effects of calmidazolium, morphine and bupivacaine on N-methyl-D-aspartate- and septide-induced nociceptive behaviour.
Topics: Analgesics; Animals; Bupivacaine; Imidazoles; Male; Morphine; N-Methylaspartate; Pain; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Spinal Cord; Substance P | 1998 |
d-Methadone blocks morphine tolerance and N-methyl-D-aspartate-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Agonists; Hyperalgesia; Injections, Spinal; Male; Methadone; Mice; Morphine; N-Methylaspartate; Pain Measurement; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1999 |
Electrophysiological effects of opioid receptor activation on Syrian hamster suprachiasmatic nucleus neurones in vitro.
Topics: Action Potentials; Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Clonidine; Cricetinae; Enkephalin, Leucine; Enkephalin, Methionine; Excitatory Amino Acid Antagonists; Male; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neurons; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Suprachiasmatic Nucleus; Time Factors | 1999 |
Prenatal morphine exposure alters N-methyl-D-aspartate- and kainate-induced seizures in adult male rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Fetus; Kainic Acid; Male; Morphine; N-Methylaspartate; Narcotics; Pregnancy; Rats; Seizures | 2000 |
Chronic morphine increases GABA tone on serotonergic neurons of the dorsal raphe nucleus: association with an up-regulation of the cyclic AMP pathway.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Cardiovascular Agents; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Isoquinolines; Male; Membrane Potentials; Morphine; N-Methylaspartate; Neural Inhibition; Periaqueductal Gray; Phenylephrine; Pyrimidines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Substance Withdrawal Syndrome; Sulfonamides; Sympathomimetics; Tetrazoles; Tetrodotoxin; Thionucleotides | 2000 |
Diazepam modifies the effect of pedunculopontine lesions on morphine but not on amphetamine conditioned place preference.
Topics: Amphetamine; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Brain Injuries; Central Nervous System Stimulants; Conditioning, Psychological; Diazepam; Excitatory Amino Acid Agonists; Male; Maze Learning; Morphine; N-Methylaspartate; Narcotics; Rats; Rats, Long-Evans; Tegmentum Mesencephali | 2000 |
Molecular evidence for the involvement of NR2B subunit containing N-methyl-D-aspartate receptors in the development of morphine-induced place preference.
Topics: Animals; Antibodies; Behavior, Animal; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; N-Methylaspartate; Neurons; Prosencephalon; Receptors, N-Methyl-D-Aspartate; Reward; Seizures | 2000 |
Chemical kindling and seizure susceptibility in morphine dependent rats.
Topics: Animals; Caffeine; Convulsants; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; GABA Antagonists; Kindling, Neurologic; Male; Morphine; Morphine Dependence; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA; Receptors, Purinergic P1; Seizures | 2000 |
Knockdown of spinal metabotropic glutamate receptor 1 (mGluR(1)) alleviates pain and restores opioid efficacy after nerve injury in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Blotting, Western; Cold Temperature; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Knockout; Morphine; N-Methylaspartate; Oligonucleotides, Antisense; Pain; Pain Measurement; Phorbol 12,13-Dibutyrate; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate; Sciatic Nerve; Touch | 2001 |
Estrogen differentially alters NMDA- and kainate-induced seizures in prenatally morphine- and saline-exposed adult female rats.
Topics: Analgesics, Opioid; Animals; Estradiol; Excitatory Amino Acid Agonists; Female; Kainic Acid; Morphine; N-Methylaspartate; Ovariectomy; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Seizures; Sodium Chloride; Stereotyped Behavior | 2000 |
Study the mechanisms of U-50,488 to prevent the development of morphine tolerance in guinea pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Drug Tolerance; Excitatory Amino Acid Agonists; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Male; Morphine; N-Methylaspartate; Narcotics; Nitric Oxide; Pain Threshold; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tritium | 2000 |
Inverse agonist action of Leu-enkephalin at delta(2)-opioid receptors mediates spinal antianalgesia.
Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Cholecystokinin; Drug Tolerance; Enkephalin, Leucine; Excitatory Amino Acid Agonists; Male; Mice; Morphine; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, delta; Spinal Cord | 2001 |
Morphine acutely and persistently attenuates nonvesicular GABA release in rat nucleus accumbens.
Topics: Analgesics; Animals; Benzeneacetamides; Carrier Proteins; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Male; Morphine; Morphine Dependence; N-Methylaspartate; Naloxone; Neural Inhibition; Neurons; Nucleus Accumbens; Organ Culture Techniques; Pyrrolidines; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Tritium | 2001 |
Co-administration of dextromethorphan during pregnancy and throughout lactation significantly decreases the adverse effects associated with chronic morphine administration in rat offspring.
Topics: Analgesics, Opioid; Animals; Antitussive Agents; Body Weight; Dextromethorphan; Drug Combinations; Drug Tolerance; Female; Hippocampus; Injections, Subcutaneous; Lactation; Longevity; Male; Morphine; Morphine Dependence; N-Methylaspartate; Pain Measurement; Pain Threshold; Pregnancy; Pregnancy, Animal; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 2001 |
Unilateral hot plate test: a simple and sensitive method for detecting central and peripheral hyperalgesia in mice.
Topics: Analgesics, Opioid; Animals; Central Nervous System Diseases; Dinoprostone; Excitatory Amino Acid Agonists; Functional Laterality; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Mice; Morphine; N-Methylaspartate; Pain Measurement; Peripheral Nervous System Diseases; Reaction Time | 2002 |
Interactions of NMDA antagonists and an alpha 2 agonist with mu, delta and kappa opioids in an acute nociception assay.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzamides; Clonidine; Dextromethorphan; Dose-Response Relationship, Drug; Drug Synergism; Fentanyl; Ketamine; Male; Mice; Morphine; N-Methylaspartate; Pain; Pain Measurement; Piperazines; Reaction Time; Receptors, Opioid | 2002 |
Genetic dissociation of opiate tolerance and physical dependence in delta-opioid receptor-1 and preproenkephalin knock-out mice.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Enkephalins; Gene Targeting; Mice; Mice, Knockout; Morphine; Morphine Dependence; N-Methylaspartate; Protein Precursors; Receptors, Opioid, delta; Substance Withdrawal Syndrome | 2002 |
Repeated spatial acquisition: effects of NMDA antagonists and morphine.
Topics: Analgesics, Opioid; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Phencyclidine; Rats; Rats, Sprague-Dawley; Serial Learning; Space Perception | 2003 |
Excitotoxic lesions of the tegmental pedunculopontine nucleus impair copulation in naive male rats and block the rewarding effects of copulation in experienced male rats.
Topics: Animals; Conditioning, Classical; Copulation; Diazepam; Excitatory Amino Acid Agonists; Female; GABA Modulators; Male; Morphine; N-Methylaspartate; Narcotics; Ovariectomy; Pedunculopontine Tegmental Nucleus; Rats; Rats, Long-Evans; Reward; Sexual Behavior, Animal | 2003 |
An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception, hyperalgesia, and morphine tolerance.
Topics: Analgesics, Opioid; Animals; Autoradiography; Behavior, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formaldehyde; Glycine; Hyperalgesia; Indoles; Injections, Spinal; Morphine; N-Methylaspartate; Narcotics; Oligonucleotides, Antisense; Pain; Pain Measurement; Rats; Reaction Time; Receptors, N-Methyl-D-Aspartate; RNA Probes; RNA, Messenger; Spinal Cord | 2005 |
Morphine causes a delayed increase in glutamate receptor functioning in the nucleus accumbens core.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; gamma-Aminobutyric Acid; Glutamic Acid; Injections, Subcutaneous; Male; Morphine; N-Methylaspartate; Nucleus Accumbens; Potassium; Rats; Rats, Wistar; Receptors, Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription, Genetic; Tritium | 2005 |
Involvement of the bed nucleus of the stria terminalis activated by the central nucleus of the amygdala in the negative affective component of morphine withdrawal in rats.
Topics: Amygdala; Animals; Avoidance Learning; Behavior, Animal; Cell Count; Conditioning, Psychological; Drug Interactions; Immunohistochemistry; Male; Morphine; Morphine Dependence; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neural Pathways; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Septal Nuclei; Substance Withdrawal Syndrome | 2005 |
The influence of NMDA receptor agonist and antagonist on morphine state-dependent memory of passive avoidance in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Injections, Intraventricular; Male; Memory; Mental Recall; Mice; Morphine; N-Methylaspartate; Narcotics; Receptors, N-Methyl-D-Aspartate | 2005 |
A role for the periaqueductal gray in switching adaptive behavioral responses.
Topics: Adaptation, Psychological; Animals; Animals, Newborn; Behavior, Animal; Female; Functional Laterality; Inhibition, Psychological; Male; Maternal Behavior; Morphine; N-Methylaspartate; Narcotics; Periaqueductal Gray; Predatory Behavior; Pregnancy; Prenatal Exposure Delayed Effects; Rats | 2006 |
Subpopulation of dorsal horn neurons displays enhanced N-methyl-D-aspartate receptor function after chronic morphine exposure.
Topics: 2-Amino-5-phosphonovalerate; Animals; Magnesium; Morphine; N-Methylaspartate; Naloxone; Posterior Horn Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2006 |
Interactions between an N-methyl-D-aspartate antagonist and low-efficacy opioid receptor agonists in assays of schedule-controlled responding and thermal nociception.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Butorphanol; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Morphine; N-Methylaspartate; Nalbuphine; Receptors, Opioid | 2006 |
S-Nitrosoglutathione and glutathione act as NMDA receptor agonists in cultured hippocampal neurons.
Topics: Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Female; Glutamic Acid; Glutathione; Hippocampus; Magnesium; Morphine; N-Methylaspartate; Neurons; Nitric Oxide Donors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; S-Nitrosoglutathione; Signal Transduction; Synaptosomes | 2006 |
Restoration of morphine-induced alterations in rat submandibular gland function by N-methyl-D-aspartate agonist.
Topics: Analgesics, Opioid; Animals; Calcium; Excitatory Amino Acid Antagonists; Glutamates; Male; Morphine; N-Methylaspartate; Piperazines; Potassium; Rats; Rats, Sprague-Dawley; Saliva; Sodium; Submandibular Gland | 2006 |
NMDA receptors of dorsal hippocampus are involved in the acquisition, but not in the expression of morphine-induced place preference.
Topics: Animals; Conditioning, Psychological; Dizocilpine Maleate; Hippocampus; Male; Morphine; Motor Activity; N-Methylaspartate; Narcotics; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2007 |
A test of the opponent-process theory of motivation using lesions that selectively block morphine reward.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Excitatory Amino Acid Agonists; Food Preferences; Male; Models, Biological; Morphine; Motivation; N-Methylaspartate; Naloxone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar; Reward; Tegmentum Mesencephali | 2007 |
Intrathecal substance P (1-7) prevents morphine-evoked spontaneous pain behavior via spinal NMDA-NO cascade.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Glutamic Acid; Male; Morphine; N-Methylaspartate; Nitrates; Nitric Oxide; Nitrites; Pain; Peptide Fragments; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Time Factors | 2007 |
Transient allodynia pain models in mice for early assessment of analgesic activity.
Topics: Adrenergic alpha-Antagonists; Amines; Amitriptyline; Analgesics; Animals; Clonidine; Cyclohexanecarboxylic Acids; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Memantine; Mice; Mice, Inbred C57BL; Morphine; N-Methylaspartate; Pain; Peripheral Nervous System; Phenylephrine; Piperazines; Prostaglandin Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, N-Methyl-D-Aspartate; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Reproducibility of Results; Spinal Cord; Spinal Nerves; Time Factors | 2008 |
Sex differences in NMDA antagonist enhancement of morphine antihyperalgesia in a capsaicin model of persistent pain: comparisons to two models of acute pain.
Topics: Acute Disease; Analgesics, Opioid; Animals; Capsaicin; Data Interpretation, Statistical; Dextromethorphan; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Hot Temperature; Hyperalgesia; Male; Morphine; N-Methylaspartate; Pain Measurement; Rats; Rats, Inbred F344; Sex Characteristics | 2008 |
Tegmental pedunculopontine glutamate and GABA-B synapses mediate morphine reward.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Baclofen; Behavior, Animal; Bicuculline; Conditioning, Operant; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; Male; Morphine; N-Methylaspartate; Narcotics; Pedunculopontine Tegmental Nucleus; Rats; Rats, Wistar; Receptors, GABA-B; Receptors, Glutamate; Reward | 2009 |
Insular cortex lesions and morphine-induced suppression of conditioned stimulus intake in the rat.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Conditioning, Operant; Eating; Excitatory Amino Acid Agonists; Male; Morphine; N-Methylaspartate; Narcotics; Rats; Saccharin; Sweetening Agents; Taste | 2009 |
Basolateral amygdala and morphine-induced taste avoidance in the rat.
Topics: Amygdala; Animals; Avoidance Learning; Male; Microinjections; Morphine; N-Methylaspartate; Rats; Rats, Inbred Strains | 2010 |
Role of ventral hippocampal NMDA receptors in anxiolytic-like effect of morphine.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Excitatory Amino Acid Antagonists; Hippocampus; Mice; Microinjections; Morphine; Motor Activity; N-Methylaspartate; Narcotics; Receptors, N-Methyl-D-Aspartate | 2010 |
Involvement of central amygdala NMDA receptor mechanism in morphine state-dependent memory retrieval.
Topics: 2-Amino-5-phosphonovalerate; Amnesia; Amygdala; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Male; Memory; Memory Disorders; Morphine; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2011 |
Repeated pretreatment of morphine prevents morphine-induced amnesia: A possible involvement for dorsal hippocampal NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Amnesia; Analgesics, Opioid; Animals; Avoidance Learning; Behavior, Animal; CA1 Region, Hippocampal; Drug Administration Schedule; Excitatory Amino Acid Agonists; Inhibition, Psychological; Male; Microinjections; Morphine; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2011 |
Role of the insular cortex in morphine-induced conditioned taste avoidance.
Topics: Animals; Avoidance Learning; Cerebral Cortex; Conditioning, Classical; Excitatory Amino Acid Agonists; Male; Morphine; N-Methylaspartate; Narcotics; Rats; Rats, Sprague-Dawley; Saccharin; Sweetening Agents; Taste | 2011 |
Antagonism of stimulation-produced analgesia by naloxone and N-methyl-D-aspartate: role of opioid and N-methyl-D-aspartate receptors.
Topics: Analgesia; Analgesics, Opioid; Animals; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hot Temperature; Ketamine; Male; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neuralgia; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Sciatic Nerve | 2012 |
The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control.
Topics: Animals; CHO Cells; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Drug Tolerance; G-Protein-Coupled Receptor Kinase 2; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; N-Methylaspartate; Neurons; Pain; Periaqueductal Gray; Phosphorylation; Protein Kinase C; Receptor Aggregation; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu | 2012 |
Neuroprotective potential of biphalin, multireceptor opioid peptide, against excitotoxic injury in hippocampal organotypic culture.
Topics: Animals; Enkephalins; Excitatory Amino Acid Agents; Hippocampus; Morphine; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Neuroprotective Agents; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Opioid, delta | 2011 |
Interactions of the potent D-amino acid oxidase inhibitor CBIO with morphine in pain and tolerance to analgesia.
Topics: Analgesics, Opioid; Animals; D-Amino-Acid Oxidase; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Injections, Spinal; Injections, Subcutaneous; Isoxazoles; Male; Mice; Morphine; N-Methylaspartate; Pain; Pain Measurement; Reaction Time; Receptors, N-Methyl-D-Aspartate | 2012 |
Morphine-induced nitric oxide production in PC12 cells.
Topics: Analgesics, Opioid; Animals; Lipopolysaccharides; Morphine; N-Methylaspartate; Nitric Oxide; PC12 Cells; Rats | 2012 |
Induction of P-glycoprotein and Bcrp at the rat blood-brain barrier following a subchronic morphine treatment is mediated through NMDA/COX-2 activation.
Topics: Analysis of Variance; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood Vessels; Blood-Brain Barrier; Brain; Cell Line, Transformed; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glutamic Acid; Humans; Iloprost; Male; Meloxicam; Misoprostol; Morphine; N-Methylaspartate; Narcotics; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiazines; Thiazoles; Time Factors | 2012 |
Role of NMDA and opioid receptors in neuropathic pain induced by chronic constriction injury of sciatic nerve in rats.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Ketamine; Male; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Sciatic Neuropathy | 2012 |
Role of the gustatory thalamus in taste learning.
Topics: Afferent Pathways; Amphetamine; Analgesics, Opioid; Analysis of Variance; Animals; Antimanic Agents; Avoidance Learning; Central Nervous System Stimulants; Conditioning, Psychological; Drinking; Excitatory Amino Acid Agonists; Food Deprivation; Lithium Chloride; Male; Morphine; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Taste; Thalamus | 2013 |
Opioid/NMDA receptors blockade reverses the depressant-like behavior of foot shock stress in the mouse forced swimming test.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Depression; Dizocilpine Maleate; Electroshock; Foot; Male; Mice; Morphine; Motor Activity; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Stress, Psychological; Swimming | 2014 |
Interactive HIV-1 Tat and morphine-induced synaptodendritic injury is triggered through focal disruptions in Na⁺ influx, mitochondrial instability, and Ca²⁺ overload.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; AIDS-Associated Nephropathy; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Corpus Striatum; Dendrites; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Membrane Potentials; Mice; Mice, Knockout; Mice, Transgenic; Mitochondria; Morphine; N-Methylaspartate; Primary Cell Culture; Receptors, Opioid, mu; Ryanodine; Sodium; Synapses; tat Gene Products, Human Immunodeficiency Virus | 2014 |
Does modulation of spinal N-methyl-D-aspartic acid receptor by pre-activation accelerate the development of morphine tolerance?
Topics: Animals; Drug Tolerance; Humans; Models, Neurological; Morphine; N-Methylaspartate; Neuralgia; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Nerve Roots | 2015 |
μ-Opioid and N-methyl-D-aspartate receptors in the amygdala contribute to minocycline-induced potentiation of morphine analgesia in rats.
Topics: Amygdala; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Hot Temperature; Injections, Intraperitoneal; Male; Minocycline; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Random Allocation; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu | 2015 |
The major neurotransmitter systems in the basolateral amygdala and the ventral tegmental area mediate morphine-induced memory consolidation impairment.
Topics: Amnesia; Analgesics, Opioid; Animals; Arachidonic Acids; Avoidance Learning; Basolateral Nuclear Complex; Bicuculline; Excitatory Amino Acid Agonists; GABA-A Receptor Antagonists; Male; Memory Consolidation; Morphine; N-Methylaspartate; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Ventral Tegmental Area | 2017 |
Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.
Topics: Animals; Anticonvulsants; Cannabidiol; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; Mice, Knockout; Morphine; N-Methylaspartate; Nociception; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Seizures; Sigma-1 Receptor; Stroke | 2018 |
The role of calcium-calmodulin-dependent protein kinase II in modulation of spatial memory in morphine sensitized rats.
Topics: Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Hippocampus; Male; Maze Learning; Memory Disorders; Morphine; N-Methylaspartate; Narcotics; Nootropic Agents; Opioid-Related Disorders; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spatial Memory; Sulfonamides | 2019 |
Inhibition of HINT1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Crystallography, X-Ray; Female; Male; Mice; Morphine; N-Methylaspartate; Nerve Tissue Proteins; Nociception; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Signal Transduction; Spinal Cord | 2019 |
Spermidine, a positive modulator of the NMDA receptor, facilitates extinction and prevents the reinstatement of morphine-induced conditioned place preference in mice.
Topics: Animals; Conditioning, Classical; Drug-Seeking Behavior; Extinction, Psychological; Male; Mice; Morphine; Motor Activity; N-Methylaspartate; Opioid-Related Disorders; Receptors, N-Methyl-D-Aspartate; Spermidine | 2020 |
Interaction of morphine tolerance with pentylenetetrazole-induced seizure threshold in mice: The role of NMDA-receptor/NO pathway.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Mice; Morphine; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate; Seizures | 2020 |
Effect of suvorexant on morphine tolerance and dependence in mice: Role of NMDA, AMPA, ERK and CREB proteins.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Opioid; Animals; Azepines; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Drug Tolerance; Male; MAP Kinase Signaling System; Mice; Morphine; Morphine Dependence; N-Methylaspartate; Triazoles | 2021 |
The role of NMDA glutamate receptors in the lateral habenula on morphine-induced conditioned place preference in rats.
Topics: Animals; Dizocilpine Maleate; Glutamic Acid; Habenula; Male; Morphine; N-Methylaspartate; Narcotics; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2023 |
Inhibitory effect of berberine on morphine tolerance and hyperalgesia in mice.
Topics: Animals; Berberine; HEK293 Cells; Humans; Hyperalgesia; Mice; Molecular Docking Simulation; Morphine; N-Methylaspartate; Nitric Oxide | 2023 |