Page last updated: 2024-08-22

n-methylaspartate and memantine

n-methylaspartate has been researched along with memantine in 110 studies

Research

Studies (110)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	37 (33.64)	18.2507
2000's	37 (33.64)	29.6817
2010's	27 (24.55)	24.3611
2020's	9 (8.18)	2.80

Authors

Authors	Studies
Osborne, NN; Quack, G	1
Feuerstein, TJ; Jackisch, R; Koch, R; Lücking, CH; Lupp, A	1
Aggarwal, SK; Chen, HS; Jensen, FE; Lei, SZ; Lipton, SA; Pellegrini, JW; Warach, S	1
Block, F; Schwarz, M; Sontag, KH	1
Lipton, SA	1
Erdö, SL; Schäfer, M	1
Frey, HH; Voits, M	1
Deshpande, SS; Filbert, MG; Smith, CD	1
Herrera, AJ; Osborne, NN	1
Apland, JP; Cann, FJ	1
Danysz, W; Dill, D; Gossel, M; Quack, G; Zajaczkowski, W	1
Danysz, W; Quack, G; Rogoz, Z; Skuza, G	1
Challiss, RA; Mistry, R; Wilke, R	1
Danysz, W; Mobley, SL; Wenk, GL	2
Gruner, R; Lodge, D; Millar, J; Parsons, CG; Rozental, J	1
Eisenberg, E; Strassman, AM; Vos, BP	1
Ando, S; Kijjoa, A; Klöcking, HP; Kunisada, T; Müller, WE; Schröder, HC; Ushijima, H	1
Bormann, J; Kornhuber, J	1
Bashir, ZI; Collingridge, GL; Frankiewicz, T; Parsons, CG; Potier, B	1
Kornhuber, J; Weller, M	1
Kelve, M; Müller, WE; Pergande, G; Perovic, S; Schleger, C; Ushijima, H	1
Benke, TA; Bresink, I; Collett, VJ; Collingridge, GL; Henley, JM; Parsons, CG; Seal, AJ	1
Ferger, D; Krieglstein, J	1
Krishtal, OA; Panchenko, VA; Parsons, CG; Pinchenko, VO; Tsyndrenko, AY	1
Chen, HS; Lipton, SA	1
Danysz, W; Wenk, GL; Zajaczkowski, W	1
Klenk-Majewska, B; Ossowska, G; Szymczyk, G	1
Aizenman, E; Blanpied, TA; Boeckman, FA; Johnson, JW	1
Daum, I; Egerter, R; Klockgether, T; Löschmann, PA; Schepelmann, K; Schugens, MM	1
Danysz, W; Frankiewicz, T; Parsons, CG; Zajaczkowski, W	1
Bach, M; Feuerstein, TJ; Knörle, R; Lagrèze, WA	1
Lanthorn, TH; Mealing, GA; Morley, P; Murray, CL; Small, DL	1
Dichgans, J; Klockgether, T; Löschmann, PA; Schepelmann, K; Schugens, MM	1
Dreyer, EB; Heng, JE; Lessell, E; Levin, LA; Vorwerk, CK; Zurakowski, D	1
Allgaier, C; Feuerstein, TJ; Illes, P; Müller, D; Scheibler, P	1
Addo, A; Dertwinkel, R; Janssen, F; Malin, JP; Schwenkreis, P; Tegenthoff, M; Witscher, K; Zenz, M	1
Emre, M; Hanağasi, HA; Kaptanoglu, G; Sahin, HA	1
Ikonomidou, C; Stefovska, V; Turski, L	1
Eshak, M; Iannotti, F; Pringle, AK; Self, J	1
Chizh, BA; Englberger, W; Haase, G; Reissmüller, E; Scheede, M; Schlütz, H	1
Anttila, V; Heinonen, H; Hirvonen, J; Jäntti, V; Juvonen, T; Kiviluoma, K; Ohtonen, P; Pokela, M; Rimpiläinen, J; Vainionpää, V	1
Mahal, B; Parsons, C; Pestel, E; Putzke, J; Rammes, G; Schadrack, J; Spanagel, R; Spielmanns, P; Zieglgänsberger, W	1
Dreyer, EB; McDermott, LM; Naskar, R; Quinto, KM; Schuettauf, F; Vorwerk, CK; Zurakowski, D	1
Ehrenberger, K; Felix, D; Oestreicher, E	1
Forette, F; Möbius, HJ; Orgogozo, JM; Rigaud, AS; Stöffler, A	1
Baudry, M; Panchenko, V; Shimono, K; Taketani, M	1
Fischman, MW; Foltin, RW; Haney, M; Hart, CL	1
Doody, R; Ferris, S; Möbius, HJ; Reisberg, B; Schmitt, F; Stöffler, A	1
Fischhof, PK	1
Gmiro, VE; Gorbunova, LV; Lukomskaya, NY; Rukoyatkina, NI	1
Bleich, S; Kornhuber, J; Wiltfang, J	1
Bachurin, SO; Dranyi, OA; Grigorev, VV	1
Hackman, JC; Holohean, AM	1
Perras, C	1
Malin, JP; Pleger, B; Schwenkreis, P; Tegenthoff, M; Witscher, K	1
Foltin, RW; Haney, M; Hart, CL; Vosburg, SK	1
Ahmed, S; Farlow, MR; Hake, AM; Sabbagh, MN	1
Dalby-Brown, W; Ding, D; Fitzgerald, S; Hilczmayer, E; Lobarinas, E; Mirza, N; Salvi, R; Sun, W; Yang, G; Zhang, L	1
Bernardi, G; Berretta, N; Cucchiaroni, ML; Giustizieri, M; Guatteo, E; Mercuri, NB	1
Berghmans, S; Best, JD; Clarke, SC; Fleming, A; Goldsmith, P; Hunt, JJ; Roach, AG	1
Gilling, KE; Jatzke, C; Parsons, CG	1
Heinz, A; Hinzpeter, A; Krebs, M; Leopold, K; Schaefer, M	1
Cheevers, CV; Donello, JE; Gil, DW	1
Attwell, D; Bakiri, Y; Hamilton, NB; Káradóttir, R	1
Downey, D	1
Eisenach, J; Horais, KA; Lafranco, L; Malkmus, S; Rathbun, M; Tozier, N; Yaksh, TL	1
Alpérovitch, A; Dartigues, JF; Lacombe, JM; Pasquier, F; Robert, P; Tzourio, C; Vidal, JS	1
Hare, WA; Wheeler, L	1
Danesh-Meyer, HV; Levin, LA	1
Chang, RC; Ho, YS; So, KF; Yik, SY; Yu, MS; Yuen, WH	1
Avila, J; Goñi-Oliver, P; Hernández, F	1
Fries, GR; Kapczinski, F; Kirsch, TR; Quevedo, J; Réus, GZ; Roesler, R; Stringari, RB	1
Gacsályi, I; Kapus, G; Kertész, S; Lévay, G	1
Di Rocco, A; Howard, J; Varanese, S	1
Büttner, T; Csoti, I; Kassubek, J; Reichmann, H; Riederer, P; Schulz, JB; Wüllner, U	1
Hayashi, T; Murata, T; Nakamura-Yanagidaira, T; Sano, K; Takahashi, Y	1
Bedel, P; Cekmen, N; Erdemli, O	1
Canning, BJ; Hilton, ECY; Saulsberry, L; Smith, JA	1
Costa, AC; Scott-McKean, JJ	1
Aarsland, D; Ballard, C; Bullock, R; Corbett, A; Francis, PT; Hanney, M; Johnson, T; Jones, EL; Lawrence, D; Prasher, V; Tyrer, S; Williams, N; Yu, LM	1
Hrubá, E; Korábecný, J; Kuca, K; Musílek, K; Nepovímová, E; Opletalová, V; Soukup, O; Spilovská, K; Zemek, F	1
Harris, J; McClymont, DW; Mellor, IR	1
Nakamura, Y	1
Ang, KK; Browning, MD; Coultrap, S; Davies, KD; Grosshans, DR; Pinnix, C; Tailor, R; Wu, PH	1
Agin, V; Ali, C; Gauberti, M; Hébert, M; Jullienne, A; Le Béhot, A; Lesept, F; Louessard, M; Maubert, E; Montagne, A; Orset, C; Vivien, D	1
Bading, H; Bengtson, CP; Hardingham, GE; McKay, S; Wyllie, DJ	1
Andrechek, E; Hollern, D; Liao, J; Wang, H; Zhou, X	1
Bykov, VN; Chepur, SV; Iudin, MA; Ivanov, IM; Kurpiakova, AF; Nikiforov, AS; Subbotina, SN	1
Akyol, E; Brothwell, SL; Gibb, AJ; Jones, S; Kimkool, P; Skepper, JN; Wild, AR	1
de Corso, E; Eramo, SL; Fetoni, AR; Paciello, F; Paludetti, G; Podda, MV; Ralli, M; Salvi, R; Troiani, D	1
Abraham, R; Nirogi, R; Shinde, A	1
Gmiro, VE; Serdyuk, SE; Veselkina, OS	1
Chopra, K; Dhir, A	1
Ellisman, MH; Hoshijima, M; Ju, WK; Kim, KY; Lukas, TJ; Noh, YH; Perkins, GA; Weinreb, RN	1
Johnson, SW; Wu, YN	1
Güntert, T; Hänggi, P; Hornemann, T; Ogunshola, OO; Othman, A; Sonda, S; Suriyanarayanan, S; Zuellig, RA	1
Amin, H; Berdondini, L; Lonardoni, D; Maccione, A; Nieus, T	1
Steenbergen, PJ	1
Al-Baggou, BK; Salih, NA	1
Chuchmacz, J; Czarnecka, K; Szymański, P; Wójtowicz, P	1
Ganjkhani, M; Khosravi, M; Meftahi, GH; Rahimi, M; Sahraei, H; Sahraei, M	1
Jeong, YI; Kim, D; Kim, T; Park, JS	1
Kusiak, A; Ossowska, A; Świetlik, D	1
Bae, YS; Cha, JH; Kim, MH; Kim, YS; Oh, SP; Song, WS; Yoon, SH	1
Eterovic, VA; Ferchmin, PA; Ferrer-Acosta, Y; Martins, AH; Pérez, D; Rodriguez-Massó, S	1
Adams, N; Cope, TE; Hughes, LE; Jones, PS; Kocagoncu, E; Murley, AG; Naessens, M; Perry, A; Rouse, MA; Rowe, JB; Street, D	1
Cruz-Martins, N; Ezzat, SM; Kumar, D; Li, L; Painuli, S; Semwal, P; Sharifi-Rad, J; Taheri, Y; Zam, W; Zuo, P	1

Reviews

7 review(s) available for n-methylaspartate and memantine

Article	Year
[New therapeutic possibilities with low-affinity NMDA receptor antagonists]. Der Nervenarzt, 1996, Volume: 67, Issue:1 Topics: Aged; Alzheimer Disease; Amantadine; Antiparkinson Agents; Excitatory Amino Acid Antagonists; Glutamine; Humans; Memantine; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine	1996
Pharmacologic management of Alzheimer disease. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 2008, Volume: 40, Issue:1 Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Galantamine; Humans; Indans; Memantine; N-Methylaspartate; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine	2008
Neuroprotection: extrapolating from neurologic diseases to the eye. American journal of ophthalmology, 2009, Volume: 148, Issue:2 Topics: Animals; Clinical Trials as Topic; Disease Models, Animal; Endpoint Determination; Excitatory Amino Acid Antagonists; Glaucoma, Open-Angle; Humans; Memantine; N-Methylaspartate; Nervous System Diseases; Neuroprotective Agents; Optic Nerve Diseases; Riluzole	2009
[On the role of MAO B inhibitors and NMDA antagonists in the therapy of Parkinson's disease]. Fortschritte der Neurologie-Psychiatrie, 2010, Volume: 78 Suppl 1 Topics: Amantadine; Excitatory Amino Acid Antagonists; Humans; Indans; Memantine; Monoamine Oxidase; Monoamine Oxidase Inhibitors; N-Methylaspartate; Parkinson Disease; Piperidines; Selegiline	2010
[Intended pharmacotherapeutical approaches of Alzheimer's disease therapy]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2012, Volume: 61, Issue:1-2 Topics: Alzheimer Disease; Cholinesterase Inhibitors; Humans; Memantine; N-Methylaspartate	2012
Memantine in neurological disorders - schizophrenia and depression. Journal of molecular medicine (Berlin, Germany), 2021, Volume: 99, Issue:3 Topics: Alzheimer Disease; Antidepressive Agents; Antipsychotic Agents; Clinical Trials as Topic; Depression; Drug Repositioning; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; N-Methylaspartate; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serotonin 5-HT3 Receptor Antagonists	2021
NMDA Inhibitors: A Potential Contrivance to Assist in Management of Alzheimer's Disease. Combinatorial chemistry & high throughput screening, 2023, Volume: 26, Issue:12 Topics: Alzheimer Disease; Humans; Memantine; N-Methylaspartate; Neurodegenerative Diseases; Receptors, N-Methyl-D-Aspartate	2023

Trials

9 trial(s) available for n-methylaspartate and memantine

Article	Year
The NMDA antagonist memantine impairs classical eyeblink conditioning in humans. Neuroscience letters, 1997, Mar-07, Volume: 224, Issue:1 Topics: Adult; Affect; Blinking; Conditioning, Classical; Double-Blind Method; Excitatory Amino Acid Antagonists; Humans; Learning; Male; Memantine; Memory; N-Methylaspartate	1997
The non-competitive N-methyl-D-aspartate-antagonist memantine does not affect segmental mono- and polysynaptic reflexes in man. Neuroscience letters, 1998, Dec-04, Volume: 257, Issue:3 Topics: Adult; Binding, Competitive; Double-Blind Method; Humans; Male; Memantine; N-Methylaspartate; Pain Measurement; Reflex; Reflex, Monosynaptic	1998
Influence of the N-methyl-D-aspartate antagonist memantine on human motor cortex excitability. Neuroscience letters, 1999, Aug-06, Volume: 270, Issue:3 Topics: Adult; Cross-Over Studies; Differential Threshold; Double-Blind Method; Electric Stimulation; Electromyography; Evoked Potentials, Motor; Excitatory Amino Acid Antagonists; Female; Humans; Magnetics; Male; Memantine; Motor Cortex; N-Methylaspartate; Neural Inhibition; Physical Stimulation; Ulnar Nerve	1999
Efficacy and safety of memantine in patients with mild to moderate vascular dementia: a randomized, placebo-controlled trial (MMM 300). Stroke, 2002, Volume: 33, Issue:7 Topics: Aged; Cognition; Dementia, Vascular; Disease Progression; Dizziness; Dopamine Agents; Double-Blind Method; Female; France; Humans; Male; Memantine; Middle Aged; N-Methylaspartate; Neuropsychological Tests; Treatment Outcome	2002
Effects of the NMDA antagonist memantine on human methamphetamine discrimination. Psychopharmacology, 2002, Volume: 164, Issue:4 Topics: Adult; Affect; Arousal; Attention; Discrimination Learning; Dose-Response Relationship, Drug; Humans; Male; Memantine; Mental Recall; Methamphetamine; N-Methylaspartate; Neuropsychological Tests	2002
Memantine in moderate-to-severe Alzheimer's disease. The New England journal of medicine, 2003, Apr-03, Volume: 348, Issue:14 Topics: Activities of Daily Living; Aged; Alzheimer Disease; Behavior; Cognition; Disease Progression; Excitatory Amino Acid Antagonists; Female; Humans; Male; Memantine; Middle Aged; N-Methylaspartate; Severity of Illness Index	2003
The NMDA antagonist memantine affects training induced motor cortex plasticity--a study using transcranial magnetic stimulation. BMC neuroscience, 2005, May-12, Volume: 6 Topics: Adult; Analysis of Variance; Cross-Over Studies; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Humans; Male; Memantine; Motor Cortex; N-Methylaspartate; Neuronal Plasticity; Psychomotor Performance; Transcranial Magnetic Stimulation	2005
An evaluation of the reinforcing effects of memantine in cocaine-dependent humans. Drug and alcohol dependence, 2005, Aug-01, Volume: 79, Issue:2 Topics: Adult; Ambulatory Care; Cocaine; Cocaine-Related Disorders; Dopamine Agents; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Memantine; N-Methylaspartate; Reinforcement, Psychology	2005
Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial. Lancet (London, England), 2012, Feb-11, Volume: 379, Issue:9815 Topics: Adult; Alzheimer Disease; Cognition; Dementia; Double-Blind Method; Down Syndrome; Female; Humans; Male; Memantine; Middle Aged; N-Methylaspartate	2012

Other Studies

94 other study(ies) available for n-methylaspartate and memantine

Article	Year
Memantine stimulates inositol phosphates production in neurones and nullifies N-methyl-D-aspartate-induced destruction of retinal neurones. Neurochemistry international, 1992, Volume: 21, Issue:3 Topics: Animals; Animals, Newborn; Brain; Calcium; Carbachol; Cells, Cultured; Chickens; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Memantine; N-Methylaspartate; Neurons; Norepinephrine; Organ Specificity; Quisqualic Acid; Rabbits; Retina; Retinal Ganglion Cells; Serotonin	1992
Inhibitory effects of the antiparkinsonian drugs memantine and amantadine on N-methyl-D-aspartate-evoked acetylcholine release in the rabbit caudate nucleus in vitro. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:2 Topics: Acetylcholine; Amantadine; Animals; Caudate Nucleus; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Magnesium; Male; Memantine; N-Methylaspartate; Rabbits; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Tritium	1992
Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1992, Volume: 12, Issue:11 Topics: Animals; Cerebral Cortex; Electrophysiology; Memantine; N-Methylaspartate; Nervous System; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells	1992
N-methyl-D-aspartate (NMDA)-mediated muscle relaxant action of memantine in rats. Neuroscience letters, 1992, Aug-31, Volume: 143, Issue:1-2 Topics: Animals; Electromyography; Female; Male; Memantine; Muscle Relaxation; Muscle Spasticity; N-Methylaspartate; Rats; Rats, Mutant Strains; Rats, Wistar; Receptors, N-Methyl-D-Aspartate	1992
Memantine prevents HIV coat protein-induced neuronal injury in vitro. Neurology, 1992, Volume: 42, Issue:7 Topics: Animals; Cells, Cultured; HIV Envelope Protein gp120; Memantine; N-Methylaspartate; Neurons; Rats; Retinal Ganglion Cells	1992
Memantine is highly potent in protecting cortical cultures against excitotoxic cell death evoked by glutamate and N-methyl-D-aspartate. European journal of pharmacology, 1991, Jun-06, Volume: 198, Issue:2-3 Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Glutamine; L-Lactate Dehydrogenase; Memantine; Microscopy, Phase-Contrast; N-Methylaspartate; Rats	1991
Effect of psychotropic agents on a model of absence epilepsy in rats. Neuropharmacology, 1991, Volume: 30, Issue:6 Topics: Animals; Antidepressive Agents; Dextroamphetamine; Electroencephalography; Epilepsy; Female; Levodopa; Male; Memantine; Morphine; N-Methylaspartate; Parasympatholytics; Psychotropic Drugs; Rats; Rats, Inbred Strains	1991
Assessment of primary neuronal culture as a model for soman-induced neurotoxicity and effectiveness of memantine as a neuroprotective drug. Archives of toxicology, 1995, Volume: 69, Issue:6 Topics: Acetylcholine; Animals; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Injections, Subcutaneous; L-Lactate Dehydrogenase; Lethal Dose 50; Male; Memantine; N-Methylaspartate; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures; Soman	1995
The effect of experimental ischaemia and excitatory amino acid agonists on the GABA and serotonin immunoreactivities in the rabbit retina. Neuroscience, 1994, Volume: 59, Issue:4 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cycloleucine; Dextromethorphan; Eye Proteins; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamic Acid; Intraocular Pressure; Ischemia; Kainic Acid; Kynurenic Acid; Memantine; N-Methylaspartate; Oxygen; Potassium Cyanide; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Vessels; Serotonin	1994
Anticonvulsant effects of memantine and MK-801 in guinea pig hippocampal slices. Brain research bulletin, 1995, Volume: 37, Issue:3 Topics: Animals; Anticonvulsants; Dizocilpine Maleate; Electric Stimulation; Epilepsy; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Memantine; Membrane Potentials; N-Methylaspartate; Pyramidal Cells; Synapses; Synaptic Transmission	1995
Are NMDA antagonistic properties relevant for antiparkinsonian-like activity in rats?--case of amantadine and memantine. Journal of neural transmission. Parkinson's disease and dementia section, 1994, Volume: 7, Issue:3 Topics: Amantadine; Animals; Catalepsy; Dizocilpine Maleate; Locomotion; Male; Memantine; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Rotation; Substantia Nigra	1994
Memantine, amantadine, and L-deprenyl potentiate the action of L-dopa in monoamine-depleted rats. Journal of neural transmission. General section, 1994, Volume: 98, Issue:1 Topics: Amantadine; Animals; Bromocriptine; Dopamine; Drug Synergism; Levodopa; Male; Memantine; Motor Activity; N-Methylaspartate; Parkinson Disease; Rats; Rats, Wistar; Selegiline	1994
Modulation of NMDA effects on agonist-stimulated phosphoinositide turnover by memantine in neonatal rat cerebral cortex. British journal of pharmacology, 1995, Volume: 114, Issue:4 Topics: Animals; Animals, Newborn; Carbachol; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Drug Interactions; Female; Inositol 1,4,5-Trisphosphate; Male; Memantine; N-Methylaspartate; Neurotoxins; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Polyphosphates; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate	1995
Investigations of neurotoxicity and neuroprotection within the nucleus basalis of the rat. Brain research, 1994, Aug-29, Volume: 655, Issue:1-2 Topics: Acetylcholine; Animals; Basal Ganglia; Behavior, Animal; Cerebral Cortex; Choline O-Acetyltransferase; Male; Memantine; Memory Disorders; N-Methylaspartate; Nervous System Diseases; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Space Perception	1994
Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan). Neuropharmacology, 1993, Volume: 32, Issue:12 Topics: Animals; Cells, Cultured; Dextrorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Embryo, Mammalian; gamma-Aminobutyric Acid; Glycine; Hippocampus; Ketamine; Kinetics; Magnesium; Memantine; Membrane Potentials; N-Methylaspartate; Neurons; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Superior Colliculi	1993
The NMDA antagonist Memantine blocks pain behavior in a rat model of formalin-induced facial pain. Pain, 1993, Volume: 54, Issue:3 Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Facial Pain; Formaldehyde; Grooming; Male; Memantine; N-Methylaspartate; Pain Measurement; Rats; Rats, Sprague-Dawley	1993
HIV-1 gp120 and NMDA induce protein kinase C translocation differentially in rat primary neuronal cultures. Journal of acquired immune deficiency syndromes, 1993, Volume: 6, Issue:4 Topics: Animals; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; G(M1) Ganglioside; HIV Envelope Protein gp120; HIV-1; Intracellular Membranes; Memantine; N-Methylaspartate; Neurons; Protein Kinase C; Rats; Receptors, N-Methyl-D-Aspartate; Translocation, Genetic	1993
Neuroprotective effects of memantine. Neurology, 1993, Volume: 43, Issue:5 Topics: Animals; Dizocilpine Maleate; HIV; HIV Envelope Protein gp120; Memantine; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate	1993
Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices. British journal of pharmacology, 1996, Volume: 117, Issue:4 Topics: Action Potentials; Animals; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Memantine; N-Methylaspartate; Neurons; Rats; Synaptic Transmission	1996
MK-801, memantine and amantadine show neuroprotective activity in the nucleus basalis magnocellularis. European journal of pharmacology, 1995, Oct-06, Volume: 293, Issue:3 Topics: Amantadine; Animals; Basal Ganglia; Cerebral Cortex; Choline O-Acetyltransferase; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Memantine; N-Methylaspartate; Nervous System Diseases; Neuroprotective Agents; Rats; Receptors, N-Methyl-D-Aspartate	1995
Neurotoxicity in rat cortical cells caused by N-methyl-D-aspartate (NMDA) and gp120 of HIV-1: induction and pharmacological intervention. Progress in molecular and subcellular biology, 1996, Volume: 16 Topics: Aminopyridines; Animals; Apoptosis; Arachidonic Acid; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; HIV Envelope Protein gp120; HIV-1; Memantine; Models, Biological; N-Methylaspartate; Neurons; Neuroprotective Agents; Phospholipases A; Phospholipases A2; Rats	1996
Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells. British journal of pharmacology, 1996, Volume: 119, Issue:2 Topics: Binding, Competitive; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ion Channels; Kidney; Kinetics; Memantine; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transfection	1996
Determination of intracellular Ca2+ concentration can be a useful tool to predict neuronal damage and neuroprotective properties of drugs. Brain research, 1996, Sep-02, Volume: 732, Issue:1-2 Topics: Amantadine; Analysis of Variance; Animals; Biomarkers; Calcium; Cell Hypoxia; Cell Survival; Cells, Cultured; Chickens; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Kinetics; Memantine; N-Methylaspartate; Neurons; Neuroprotective Agents; Quinoxalines; Sodium Cyanide; Telencephalon; Time Factors	1996
Comparative patch-clamp studies with freshly dissociated rat hippocampal and striatal neurons on the NMDA receptor antagonistic effects of amantadine and memantine. The European journal of neuroscience, 1996, Volume: 8, Issue:3 Topics: Amantadine; Animals; Dose-Response Relationship, Drug; Hippocampus; Ketamine; Memantine; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate	1996
Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism. The Journal of physiology, 1997, Feb-15, Volume: 499 ( Pt 1) Topics: Animals; Dose-Response Relationship, Drug; Ion Channels; Memantine; N-Methylaspartate; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells	1997
Neuroprotection of acetylcholinergic basal forebrain neurons by memantine and neurokinin B. Behavioural brain research, 1997, Volume: 83, Issue:1-2 Topics: Acetylcholine; Animals; Basal Ganglia; Cerebral Cortex; Choline O-Acetyltransferase; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Maze Learning; Memantine; N-Methylaspartate; Neurokinin B; Neurons; Neuroprotective Agents; Parasympathetic Nervous System; Prosencephalon; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley	1997
The effect of NMDA antagonists on footshock-induced fighting behavior in chronically stressed rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1997, Volume: 48, Issue:1 Topics: Aggression; Animals; Chronic Disease; Dizocilpine Maleate; Electroshock; Excitatory Amino Acid Antagonists; Exploratory Behavior; Male; Memantine; N-Methylaspartate; Rats; Rats, Wistar; Stress, Psychological	1997
Trapping channel block of NMDA-activated responses by amantadine and memantine. Journal of neurophysiology, 1997, Volume: 77, Issue:1 Topics: Amantadine; Animals; Antiparkinson Agents; Cells, Cultured; CHO Cells; Cricetinae; DNA; Excitatory Amino Acid Agonists; Ion Channels; Kinetics; Memantine; Membrane Potentials; Models, Neurological; N-Methylaspartate; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission	1997
Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP. Neuropharmacology, 1997, Volume: 36, Issue:7 Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Long-Term Potentiation; Male; Memantine; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	1997
Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia. Investigative ophthalmology & visual science, 1998, Volume: 39, Issue:6 Topics: Animals; Cell Count; Chromatography, High Pressure Liquid; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Intraocular Pressure; Ischemia; Male; Memantine; N-Methylaspartate; Ocular Hypertension; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Retinal Vessels; Vitreous Body	1998
Differences in degree of trapping of low-affinity uncompetitive N-methyl-D-aspartic acid receptor antagonists with similar kinetics of block. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:1 Topics: Animals; Cells, Cultured; Excitatory Amino Acid Antagonists; Ketamine; Kinetics; Memantine; Mice; Mice, Inbred BALB C; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate	1999
Ethambutol is toxic to retinal ganglion cells via an excitotoxic pathway. Investigative ophthalmology & visual science, 1999, Volume: 40, Issue:1 Topics: Animals; Antitubercular Agents; Calcium; Carbocyanines; Cell Survival; Dose-Response Relationship, Drug; Ethambutol; Ethylenediamines; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glutamic Acid; Memantine; Membrane Potentials; Mitochondria; N-Methylaspartate; Rats; Retinal Ganglion Cells; Tetrazolium Salts; Thiazoles	1999
NMDA receptor characterization and subunit expression in rat cultured mesencephalic neurones. British journal of pharmacology, 1999, Volume: 126, Issue:1 Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Gene Expression; Gene Expression Regulation, Developmental; Glycine; Memantine; Mesencephalon; N-Methylaspartate; Neurons; Nitrendipine; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA Splicing; RNA, Messenger	1999
The use of NMDA antagonist memantine in drug-resistant dyskinesias resulting from L-dopa. Movement disorders : official journal of the Movement Disorder Society, 2000, Volume: 15, Issue:5 Topics: Adult; Antiparkinson Agents; Dopamine Agents; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Humans; Levodopa; Male; Memantine; N-Methylaspartate; Parkinsonian Disorders; Treatment Outcome	2000
Neuronal death enhanced by N-methyl-D-aspartate antagonists. Proceedings of the National Academy of Sciences of the United States of America, 2000, Nov-07, Volume: 97, Issue:23 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Injuries; Cell Death; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Memantine; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Piperazines; Propionates; Quinoxalines; Rats; Rats, Wistar; Wounds and Injuries	2000
Reducing conditions significantly attenuate the neuroprotective efficacy of competitive, but not other NMDA receptor antagonists in vitro. The European journal of neuroscience, 2000, Volume: 12, Issue:11 Topics: 2-Amino-5-phosphonovalerate; Animals; Dithionitrobenzoic Acid; Dithiothreitol; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Ischemic Attack, Transient; Memantine; N-Methylaspartate; Neurons; Neuroprotective Agents; Organ Culture Techniques; Piperazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate	2000
Supraspinal vs spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil. Neuropharmacology, 2001, Volume: 40, Issue:2 Topics: Analgesics; Animals; Decerebrate State; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Male; Memantine; Motor Activity; N-Methylaspartate; Naloxone; Narcotic Antagonists; Pain; Piperidines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord	2001
The N-methyl-D-aspartate antagonist memantine has no neuroprotective effect during hypothermic circulatory arrest: a study in the chronic porcine model. The Journal of thoracic and cardiovascular surgery, 2001, Volume: 121, Issue:5 Topics: Animals; Behavior, Animal; Brain; Cardiopulmonary Bypass; Electroencephalography; Female; Glucose; Glutamic Acid; Glycerol; Heart Arrest, Induced; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Lactic Acid; Memantine; Microdialysis; N-Methylaspartate; Neuroprotective Agents; Swine	2001
The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801. Neuropharmacology, 2001, Volume: 40, Issue:6 Topics: Acamprosate; Alcohol Deterrents; Animals; Brain; Cell Line; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Humans; Male; Memantine; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Taurine; Xenopus	2001
Excitotoxicity can be mediated through an interaction within the optic nerve; activation of cell body NMDA receptors is not required. Veterinary ophthalmology, 2001, Volume: 4, Issue:3 Topics: Animals; Axotomy; Cell Survival; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Memantine; N-Methylaspartate; Nerve Crush; Optic Nerve; Optic Nerve Injuries; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells	2001
Different action of memantine and caroverine on glutamatergic transmission in the mammalian cochlea. Advances in oto-rhino-laryngology, 2002, Volume: 59 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cochlea; Dopamine Agents; Female; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory, Inner; Memantine; N-Methylaspartate; Neurons, Afferent; Quinoxalines	2002
Chronic multichannel recordings from organotypic hippocampal slice cultures: protection from excitotoxic effects of NMDA by non-competitive NMDA antagonists. Journal of neuroscience methods, 2002, Oct-30, Volume: 120, Issue:2 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Dizocilpine Maleate; Electrodes, Implanted; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Male; Memantine; N-Methylaspartate; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission	2002
Comments on the NMDA antagonist memantine. Methods and findings in experimental and clinical pharmacology, 2003, Volume: 25, Issue:3 Topics: Aged; Clinical Trials as Topic; Dementia; Dopamine Agents; Humans; Memantine; N-Methylaspartate	2003
The ability of new non-competitive glutamate receptor blockers to weaken motor disorders in animals. Neuroscience and behavioral physiology, 2003, Volume: 33, Issue:3 Topics: Animals; Ataxia; Behavior, Animal; Catalepsy; Diamines; Disease Models, Animal; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Haloperidol; Kainic Acid; Memantine; Mice; Mice, Inbred Strains; N-Methylaspartate; Quaternary Ammonium Compounds; Seizures; Structure-Activity Relationship; Time Factors	2003
[Early treatment with anti-dementia drugs when possible. These signs reveal Alzheimer disease]. MMW Fortschritte der Medizin, 2003, Jun-05, Volume: 145, Issue:23 Topics: Alzheimer Disease; Cholinesterase Inhibitors; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Humans; Memantine; N-Methylaspartate	2003
Memantine in moderate-to-severe Alzheimer's disease. The New England journal of medicine, 2003, Aug-07, Volume: 349, Issue:6 Topics: Alzheimer Disease; Excitatory Amino Acid Antagonists; Homocysteine; Humans; Hyperhomocysteinemia; Memantine; N-Methylaspartate	2003
Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons. Bulletin of experimental biology and medicine, 2003, Volume: 136, Issue:5 Topics: Animals; Benzothiadiazines; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Indoles; Kainic Acid; Memantine; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Purkinje Cells; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate	2003
Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones. British journal of pharmacology, 2004, Volume: 143, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Ergolines; Excitatory Amino Acid Antagonists; Gallopamil; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Indoles; Magnesium; Memantine; Membrane Potentials; Motor Neurons; N-Methylaspartate; Nifedipine; Protein Kinase C; Pyridines; Rana pipiens; Receptor, Serotonin, 5-HT2B; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Staurosporine; Sulfonamides; Tetrodotoxin	2004
Memantine for treatment of moderate to severe Alzheimer's disease. Issues in emerging health technologies, 2005, Issue:64 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Canada; Cholinesterase Inhibitors; Dementia; Diffusion of Innovation; Dopamine Agents; Drug Approval; Drug Therapy, Combination; Humans; Indans; Memantine; N-Methylaspartate; Nootropic Agents; Randomized Controlled Trials as Topic; Risk Factors	2005
The use of memantine in dementia with Lewy bodies. Journal of Alzheimer's disease : JAD, 2005, Volume: 7, Issue:4 Topics: Aged; Aged, 80 and over; Dopamine Agents; Female; Humans; Lewy Body Disease; Male; Memantine; N-Methylaspartate; Prospective Studies	2005
Salicylate- and quinine-induced tinnitus and effects of memantine. Acta oto-laryngologica. Supplementum, 2006, Issue:556 Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Auditory Cortex; Dose-Response Relationship, Drug; Evoked Potentials, Auditory; Memantine; N-Methylaspartate; Parasympatholytics; Quinine; Rats; Rats, Sprague-Dawley; Salicylic Acid; Tinnitus	2006
Memantine inhibits ATP-dependent K+ conductances in dopamine neurons of the rat substantia nigra pars compacta. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:2 Topics: Action Potentials; Adenosine Triphosphate; Animals; Cell Hypoxia; Dizocilpine Maleate; Dopamine; Glucose; In Vitro Techniques; Memantine; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Tolbutamide	2007
Non-associative learning in larval zebrafish. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:5 Topics: Acoustic Stimulation; Age Factors; Analysis of Variance; Animals; Area Under Curve; Behavior, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Habituation, Psychophysiologic; Inhibition, Psychological; Larva; Memantine; N-Methylaspartate; Reflex, Startle; Zebrafish	2008
Agonist concentration dependency of blocking kinetics but not equilibrium block of N-methyl-D-aspartate receptors by memantine. Neuropharmacology, 2007, Volume: 53, Issue:3 Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Hippocampus; Kinetics; Memantine; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate	2007
Memantine-associated reversal of clozapine-induced weight gain. Pharmacopsychiatry, 2007, Volume: 40, Issue:4 Topics: Adult; Antipsychotic Agents; Clozapine; Dopamine Agents; Humans; Male; Memantine; N-Methylaspartate; Obesity; Schizophrenia	2007
Transient allodynia pain models in mice for early assessment of analgesic activity. British journal of pharmacology, 2008, Volume: 153, Issue:4 Topics: Adrenergic alpha-Antagonists; Amines; Amitriptyline; Analgesics; Animals; Clonidine; Cyclohexanecarboxylic Acids; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Memantine; Mice; Mice, Inbred C57BL; Morphine; N-Methylaspartate; Pain; Peripheral Nervous System; Phenylephrine; Piperazines; Prostaglandin Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, N-Methyl-D-Aspartate; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Reproducibility of Results; Spinal Cord; Spinal Nerves; Time Factors	2008
Testing NMDA receptor block as a therapeutic strategy for reducing ischaemic damage to CNS white matter. Glia, 2008, Jan-15, Volume: 56, Issue:2 Topics: Action Potentials; Animals; Animals, Newborn; Brain Ischemia; Central Nervous System; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Memantine; Myelin Basic Protein; N-Methylaspartate; Oligodendroglia; Patch-Clamp Techniques; Protein Binding; Rats; Receptors, N-Methyl-D-Aspartate	2008
Toxicology profile of N-methyl-D-aspartate antagonists delivered by intrathecal infusion in the canine model. Anesthesiology, 2008, Volume: 108, Issue:5 Topics: Amitriptyline; Animals; Dizocilpine Maleate; Dogs; Female; Infusion Pumps, Implantable; Infusions, Parenteral; Ketamine; Male; Memantine; Models, Animal; N-Methylaspartate; Sulfamethizole	2008
Evaluation of the impact of memantine treatment initiation on psychotropics use: a study from the French national health care database. Neuroepidemiology, 2008, Volume: 31, Issue:3 Topics: Aged; Alzheimer Disease; Anti-Anxiety Agents; Antipsychotic Agents; Databases, Factual; Dopamine Agents; Female; France; Humans; Hypnotics and Sedatives; Male; Memantine; N-Methylaspartate; Psychotropic Drugs; Treatment Outcome	2008
Experimental glutamatergic excitotoxicity in rabbit retinal ganglion cells: block by memantine. Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:6 Topics: Action Potentials; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Electroretinography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Memantine; N-Methylaspartate; Photic Stimulation; Rabbits; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells	2009
Polysaccharides from wolfberry antagonizes glutamate excitotoxicity in rat cortical neurons. Cellular and molecular neurobiology, 2009, Volume: 29, Issue:8 Topics: Animals; Antioxidants; Cell Death; Cerebral Cortex; Glutamic Acid; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Lycium; Memantine; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Phosphorylation; Polysaccharides; Rats	2009
Memantine inhibits calpain-mediated truncation of GSK-3 induced by NMDA: implications in Alzheimer's disease. Journal of Alzheimer's disease : JAD, 2009, Volume: 18, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Calpain; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Female; Glycogen Synthase Kinase 3; Humans; Inhibitory Concentration 50; Male; Memantine; Middle Aged; N-Methylaspartate; Neurons; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Signal Transduction	2009
Neurochemical and behavioural effects of acute and chronic memantine administration in rats: Further support for NMDA as a new pharmacological target for the treatment of depression? Brain research bulletin, 2010, Apr-05, Volume: 81, Issue:6 Topics: Animals; Antidepressive Agents, Tricyclic; Brain-Derived Neurotrophic Factor; Depressive Disorder; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Antagonists; Exploratory Behavior; Hippocampus; Imipramine; Locomotion; Male; Memantine; Motor Activity; N-Methylaspartate; Neuropsychological Tests; Rats; Rats, Wistar; Swimming; Time Factors	2010
[Alzheimer dementia. Memantine: value for patient and caregivers]. MMW Fortschritte der Medizin, 2009, Nov-05, Volume: 151, Issue:45 Topics: Activities of Daily Living; Aged; Alzheimer Disease; Caregivers; Cognition; Cost of Illness; Dopamine Agents; Humans; Memantine; N-Methylaspartate	2009
Deramciclane improves object recognition in rats: potential role of NMDA receptors. Pharmacology, biochemistry, and behavior, 2010, Volume: 94, Issue:4 Topics: Animals; Camphanes; Chickens; Dizocilpine Maleate; Dose-Response Relationship, Drug; Evoked Potentials; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Memantine; N-Methylaspartate; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology; Retina	2010
NMDA antagonist memantine improves levodopa-induced dyskinesias and "on-off" phenomena in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society, 2010, Mar-15, Volume: 25, Issue:4 Topics: Aged; Antiparkinson Agents; Dopamine Agents; Dyskinesia, Drug-Induced; Female; Humans; Incidence; Levodopa; Male; Memantine; N-Methylaspartate; Parkinson Disease	2010
Development of spontaneous neuropathy in NF-κBp50-deficient mice by calcineurin-signal involving impaired NF-κB activation. Molecular vision, 2011, Volume: 17 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Calcineurin; Genes, Reporter; Humans; Intravitreal Injections; Luciferases; Memantine; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neuroprotective Agents; NF-kappa B p50 Subunit; Optic Nerve; Optic Nerve Diseases; Piperazines; Retinal Ganglion Cells; Signal Transduction; Tacrolimus	2011
A memantin HCL intoxication responsive to plasmapheresis therapy. Bratislavske lekarske listy, 2011, Volume: 112, Issue:9 Topics: Adult; Female; Humans; Memantine; N-Methylaspartate; Plasmapheresis	2011
Antitussive effects of memantine in guinea pigs. Chest, 2012, Volume: 141, Issue:4 Topics: Animals; Antitussive Agents; Baclofen; Bradykinin; Citric Acid; Cough; Dextromethorphan; Guinea Pigs; Ketamine; Male; Mecamylamine; Memantine; N-Methylaspartate; Serotonin	2012
Exaggerated NMDA mediated LTD in a mouse model of Down syndrome and pharmacological rescuing by memantine. Learning & memory (Cold Spring Harbor, N.Y.), 2011, Volume: 18, Issue:12 Topics: Analysis of Variance; Animals; Disease Models, Animal; Down Syndrome; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; Memantine; Methoxyhydroxyphenylglycol; Mice; Mice, Mutant Strains; N-Methylaspartate; Time Factors; Trisomy	2011
Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors. European journal of pharmacology, 2012, Jul-05, Volume: 686, Issue:1-3 Topics: Animals; Cells, Cultured; Diamines; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Glycine; Magnesium; Memantine; N-Methylaspartate; Oocytes; Phenols; Polyamines; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Xenopus laevis	2012
[New anti-AD drugs--their possibilities and issues]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2012, Volume: 114, Issue:3 Topics: Alzheimer Disease; Cholinesterase Inhibitors; Galantamine; Humans; Memantine; N-Methylaspartate; Phenylcarbamates; Rivastigmine	2012
Radiation induces acute alterations in neuronal function. PloS one, 2012, Volume: 7, Issue:5 Topics: Animals; Biological Transport; Caspase 3; Enzyme Activation; Long-Term Potentiation; Memantine; N-Methylaspartate; Neurons; Phosphorylation; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission	2012
Memantine improves safety of thrombolysis for stroke. Stroke, 2012, Volume: 43, Issue:10 Topics: Animals; Cells, Cultured; Cerebral Cortex; Chemotherapy, Adjuvant; Excitatory Amino Acid Antagonists; Fibrinolytic Agents; In Vitro Techniques; Magnetic Resonance Imaging; Male; Memantine; Mice; Models, Animal; N-Methylaspartate; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome	2012
Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure. Neuropharmacology, 2013, Volume: 74 Topics: Animals; Cations; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Magnesium; Memantine; Membrane Potentials; N-Methylaspartate; Nerve Degeneration; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Time Factors	2013
NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors. Cell death & disease, 2013, Mar-28, Volume: 4 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicuculline; Cell Death; Cell Survival; Cerebral Cortex; Extracellular Signal-Regulated MAP Kinases; Gene Expression Profiling; Gene Expression Regulation; Memantine; N-Methylaspartate; Neurons; Nifedipine; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Transcription, Genetic	2013
[Specific features of the anticonvulsant effect of memantine in mice intoxicated with a model organic phosphate]. Eksperimental'naia i klinicheskaia farmakologiia, 2013, Volume: 76, Issue:2 Topics: Acetylcholinesterase; Animals; Anticonvulsants; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocytes; Isoflurophate; Lethal Dose 50; Male; Memantine; Mice; N-Methylaspartate; Organophosphate Poisoning; Oximes	2013
Memantine block depends on agonist presentation at the NMDA receptor in substantia nigra pars compacta dopamine neurones. Neuropharmacology, 2013, Volume: 73 Topics: Animals; Cell Count; Dizocilpine Maleate; Dopaminergic Neurons; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Male; Memantine; N-Methylaspartate; Nerve Degeneration; Rats; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Tyrosine 3-Monooxygenase	2013
The effect of the NMDA channel blocker memantine on salicylate-induced tinnitus in rats. Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2014, Volume: 34, Issue:3 Topics: Animals; Excitatory Amino Acid Antagonists; Male; Memantine; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Salicylates; Tinnitus	2014
Role of glutamate and advantages of combining memantine with a 5HT6 ligand in a model of depression. Pharmacological reports : PR, 2014, Volume: 66, Issue:3 Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Glutamic Acid; Ligands; Male; Memantine; Motor Activity; N-Methylaspartate; Piperazines; Prefrontal Cortex; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Sulfonamides; Swimming	2014
Combined blockade of NMDA and AMPA receptors prevents acute kainate seizures and chronic kainate lethality in rats. Bulletin of experimental biology and medicine, 2014, Volume: 157, Issue:1 Topics: Adamantane; Amines; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Injections, Intramuscular; Kainic Acid; Male; Memantine; N-Methylaspartate; Neuroprotective Agents; Pentylenetetrazole; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Survival Analysis	2014
Memantine delayed N-methyl-D-aspartate -induced convulsions in neonatal rats. Fundamental & clinical pharmacology, 2015, Volume: 29, Issue:1 Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Male; Memantine; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures	2015
Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes. Glia, 2015, Volume: 63, Issue:5 Topics: Aged; Aged, 80 and over; Aldehyde Dehydrogenase; Animals; Astrocytes; Cell Count; Cells, Cultured; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glaucoma; Glutamic Acid; Humans; Intraocular Pressure; Memantine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Mitochondria; Mitochondrial Dynamics; N-Methylaspartate; Optic Disk; Oxidoreductases Acting on CH-NH Group Donors; Retinal Ganglion Cells	2015
Memantine selectively blocks extrasynaptic NMDA receptors in rat substantia nigra dopamine neurons. Brain research, 2015, Apr-07, Volume: 1603 Topics: Animals; Dizocilpine Maleate; Dopaminergic Neurons; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Memantine; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Pyrazoles; Quinolones; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Tissue Culture Techniques	2015
1-Deoxysphingolipid-induced neurotoxicity involves N-methyl-d-aspartate receptor signaling. Neuropharmacology, 2016, Volume: 110, Issue:Pt A Topics: Animals; Cell Line, Tumor; Cerebral Cortex; Cytoskeleton; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Humans; Memantine; Membrane Potentials; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Neuroprotective Agents; rac1 GTP-Binding Protein; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sphingolipids; Sphingosine	2016
High-resolution bioelectrical imaging of Aβ-induced network dysfunction on CMOS-MEAs for neurotoxicity and rescue studies. Scientific reports, 2017, 05-26, Volume: 7, Issue:1 Topics: Action Potentials; Adult Stem Cells; Amyloid beta-Peptides; Animals; Antiparkinson Agents; Crocus; Embryo, Mammalian; Female; Gene Expression; Hippocampus; Lab-On-A-Chip Devices; Memantine; Microelectrodes; N-Methylaspartate; Neural Stem Cells; Neurons; Peptide Fragments; Plant Extracts; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tissue Culture Techniques	2017
Response of zebrafish larvae to mild electrical stimuli: A 96-well setup for behavioural screening. Journal of neuroscience methods, 2018, 05-01, Volume: 301 Topics: Animals; Buprenorphine; Electric Stimulation; Electrodes; Equipment Design; Habituation, Psychophysiologic; Housing, Animal; Larva; Memantine; Models, Animal; Motor Activity; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neurotransmitter Agents; Proof of Concept Study; Receptors, N-Methyl-D-Aspartate; Zebrafish	2018
Effect of memantine hydrochloride on cisplatin-induced neurobehavioral toxicity in mice. Acta neurologica Belgica, 2020, Volume: 120, Issue:1 Topics: Animals; Antineoplastic Agents; Behavior, Animal; Cisplatin; Disease Models, Animal; Excitatory Amino Acid Antagonists; Male; Memantine; Mice, Inbred BALB C; N-Methylaspartate; Neuroprotective Agents; Neurotoxicity Syndromes; Psychomotor Performance	2020
Anxiogenic and anxiolytic effects of memantine injected into the ventral hippocampus in male stressed mice. Journal of complementary & integrative medicine, 2022, Sep-01, Volume: 19, Issue:3 Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Hippocampus; Male; Memantine; Mice; N-Methylaspartate; Stainless Steel	2022
The Effect of Oxidative Stress and Memantine-Incorporated Reactive Oxygen Species-Sensitive Nanoparticles on the Expression of International journal of molecular sciences, 2021, Nov-15, Volume: 22, Issue:22 Topics: Alzheimer Disease; Animals; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Drug Liberation; Humans; Male; Memantine; Mice; Mice, Inbred BALB C; Mice, Nude; N-Methylaspartate; Nanoparticles; Nerve Tissue Proteins; Neuroblastoma; Optical Imaging; Oxidative Stress; Particle Size; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Signal Transduction	2021
Computational Modeling of Therapy with the NMDA Antagonist in Neurodegenerative Disease: Information Theory in the Mechanism of Action of Memantine. International journal of environmental research and public health, 2022, 04-14, Volume: 19, Issue:8 Topics: Alzheimer Disease; Computer Simulation; Humans; Information Theory; Memantine; N-Methylaspartate; Neurodegenerative Diseases; Receptors, N-Methyl-D-Aspartate	2022
Suppression of exaggerated NMDAR activity by memantine treatment ameliorates neurological and behavioral deficits in aminopeptidase P1-deficient mice. Experimental & molecular medicine, 2022, Volume: 54, Issue:8 Topics: Aminopeptidases; Animals; Hippocampus; Memantine; Mice; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate	2022
Memantine has a nicotinic neuroprotective pathway in acute hippocampal slices after an NMDA insult. Toxicology in vitro : an international journal published in association with BIBRA, 2022, Volume: 84 Topics: Hippocampus; Memantine; N-Methylaspartate; Neuroprotection; Neuroprotective Agents; Nicotine; Phosphatidylinositol 3-Kinases; Receptors, N-Methyl-D-Aspartate	2022
The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration. Translational psychiatry, 2022, 08-27, Volume: 12, Issue:1 Topics: Cross-Over Studies; Double-Blind Method; Frontotemporal Dementia; Frontotemporal Lobar Degeneration; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Memantine; N-Methylaspartate; Neurodegenerative Diseases	2022