n-methylaspartate has been researched along with kainic acid in 1248 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 257 (20.59) | 18.7374 |
| 1990's | 741 (59.38) | 18.2507 |
| 2000's | 194 (15.54) | 29.6817 |
| 2010's | 50 (4.01) | 24.3611 |
| 2020's | 6 (0.48) | 2.80 |
| Authors | Studies |
|---|---|
| Kozikowski, AP; Reynolds, IJ; Tückmantel, W; Wroblewski, JT | 1 |
| Curry, K; Magnuson, DS; McLennan, H; Peet, MJ | 2 |
| Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM | 1 |
| Araldi, GL; Kozikowski, AP; Pshenichkin, S; Steensma, D; Surina, E; Tückmantel, W; Wang, S; Wroblewski, JT | 1 |
| Bräuner-Osborne, H; Conti, P; De Amici, M; De Micheli, C; De Sarro, G; Madsen, U; Rizzo, M; Stensbøl, TB; Toma, L | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Amir, A; Contreras-Sanz, A; Foti, A; Fruttero, R; Gasco, A; Giordano, C; Hansen, KB; Johansen, TN; Lolli, ML; Nielsen, B; Pickering, DS; Rolando, B | 1 |
| Boschi, D; Clausen, RP; Farnsworth, JC; Hansen, KB; Jensen, AA; Kastrup, JS; Lolli, ML; Møllerud, S; Nielsen, B; Passoni, A; Pickering, DS; Sainas, S; Temperini, P; Yi, F | 1 |
| Davies, J; Evans, RH; Francis, AA; Watkins, JC | 1 |
| Greene, RW; McCarley, RW; Stevens, DR | 1 |
| Hong, JS; McMillian, M; Pennypacker, KR | 1 |
| Bloms, P; Madeja, M; Musshoff, U; Speckmann, EJ | 1 |
| Larson, AA; Sun, X | 3 |
| Hansen, JJ; Krogsgaard-Larsen, P; Miledi, R; Nielsen, B; Schousboe, A; Wahl, P | 1 |
| Legendre, P; Rosenmund, C; Westbrook, GL | 1 |
| Maruyama, M; Nakazawa, M; Takeda, K | 1 |
| Haley, JE; Kitto, KF; Wilcox, GL | 1 |
| Brunner, L; Buzsáki, G; Cotman, CW; Geddes, JW | 1 |
| Engberg, G; Hajós, M | 2 |
| Boje, KM; Skolnick, P | 1 |
| Fink, K; Göthert, M; Schultheiss, R | 2 |
| Li, M; Ryan, R; Wood, PL | 2 |
| Johnson, SW; North, RA; Seutin, V | 1 |
| Jensen, TS; Yaksh, TL | 1 |
| Lasoń, W; Przewłocka, B; Przewłocki, R | 1 |
| Brann, DW; Mahesh, VB | 1 |
| Asprodini, EK; Rainnie, DG; Shinnick-Gallagher, P | 1 |
| Helm, SW; Henzi, V; MacDermott, AB; Reichling, DB | 1 |
| Di Loreto, S; Florio, T; Scarnati, E | 1 |
| Davidoff, RA; Hackman, JC; Holohean, AM; Shope, SB | 1 |
| Akoev, GN; Andrianov, GN; Ryzhova, IV; Sherman, NO | 1 |
| Cornell-Bell, AH; Finkbeiner, SM; van den Pol, AN | 1 |
| Huettner, JE; Koroshetz, WJ; Rees, AH; Swartz, KJ | 1 |
| Gay, VL; Medhamurthy, R; Plant, TM | 1 |
| Weiland, NG | 1 |
| Cai, Z; McCaslin, PP | 3 |
| Amano, T; Hishinuma, F; Kuwahara, R; Okabe, N; Ozawa, F; Yamakuni, T | 1 |
| Erdö, SL; Schäfer, M | 1 |
| Flavin, MP; Riopelle, RJ; Yang, Y | 1 |
| Chuang, DM; Gao, XM; Paul, SM | 1 |
| Dingledine, R; McBain, C | 1 |
| Eigyo, M; Ibii, N; Katsuura, G; Matsushita, A; Shinohara, S; Shintaku, H | 1 |
| Lanius, RA; Shaw, C | 3 |
| Darles, G; Graham, D; Langer, SZ | 1 |
| McCaslin, PP; Yu, XZ | 1 |
| Sekiguchi, M; Wada, K; Wenthold, RJ | 1 |
| Hamada, T; Shibata, S; Tominaga, K; Watanabe, S | 1 |
| Kurusu, R; Sakurai, H; Sano, K; Tsuchiya, T; Tsuda, M | 1 |
| Henry, JL; Hong, Y | 1 |
| De Sarro, A; De Sarro, G; Meldrum, BS; Patel, S | 1 |
| Besser, GM; Costa, A; Forsling, ML; Grossman, A; Hucks, D; Yasin, SA | 1 |
| Barnard, EA; Usherwood, PN | 1 |
| Holopainen, I; Janáky, R; Oja, SS; Saransaari, P; Varga, V | 1 |
| Chizhmakov, IV; Jackson, H; Kiskin, NI; Krishtal, OA; Mueller, AL | 1 |
| Cazalets, JR; Clarac, F; Sqalli-Houssaini, Y | 1 |
| Costa, E; Kiedrowski, L; Wroblewski, JT | 1 |
| Pittaluga, A; Raiteri, M | 1 |
| Bobichon, C; Cordi, A; Curutchet, P; de Carvalho, LP; Guet, T; Lambolez, B; Lepagnol, JM; Moreau, C; Randle, JC | 1 |
| Andersen, CF; Frandsen, A; Schousboe, A | 1 |
| Fain, GL; Yazejian, B | 1 |
| Frandsen, A; Schousboe, A | 1 |
| Donevan, SD; Jones, SM; Rogawski, MA | 1 |
| Hornfeldt, CS; Larson, AA; Schamber, CD; Smullin, DH; Sun, X | 1 |
| Aggarwal, SK; Chen, HS; Hartman, J; Lei, SZ; Lipton, SA; Pan, ZH; Sucher, NJ | 1 |
| Kawai, N; Nakajima, T; Robinson, HP; Shimazaki, K; Takenawa, T | 1 |
| Balázs, R; Hack, N; Kumar, KN; Michaelis, E; Resink, A; Van der Valk, JB | 1 |
| Crawley, JN; Finiels-Marlier, F; Leppin, C; Montpied, P; Paul, SM | 1 |
| Isacson, O; Sofroniew, MV | 1 |
| Dildy-Mayfield, JE; Harris, RA | 1 |
| Chiamulera, C; Costa, S; Reggiani, A; Valerio, E | 1 |
| Dutton, GR; Rogers, KL | 1 |
| Bleakman, D; Chard, PS; Glaum, SR; Miller, RJ; Rusin, KI | 1 |
| Lodge, D; Zeman, S | 1 |
| Oostveen, JA; Pregenzer, JF; Williams, LR | 1 |
| Davies, JA; Dickie, BG; Lewis, MJ | 1 |
| Bonhaus, DW; McNamara, JO | 1 |
| Alonso, R; Boksa, P; Chaudieu, I; Mount, H; Quirion, R | 1 |
| Baganoff, MP; Davies, MS; Grishin, EV; Lanthorn, TH; Volkova, TM; Watson, GB; Wiegand, RC | 1 |
| Grillner, S; Hill, R; Matsushima, T; Schotland, J | 1 |
| Balázs, R; Boer, GJ; Resink, A | 1 |
| Grillner, S; Hellgren, J; Lansner, A | 1 |
| De Vries, JB; Santiago, M; Westerink, BH | 1 |
| de Montigny, C; Debonnel, G; Monnet, FP | 2 |
| Mathis, C; Ungerer, A | 1 |
| Ho, IK; McCaslin, PP; Smith, TG; Yu, XZ | 1 |
| Anderson, KJ; Mitchell, JJ | 1 |
| Carter, C; Fage, D; Lloyd, KG; Porcella, A; Scatton, B; Serrano, A; Voltz, C | 1 |
| Kruk, MR; Meelis, W; Roeling, TA; van Erp, AM; Veening, JG | 1 |
| MacDonald, JF; Salter, MW; Wang, LY | 1 |
| Smith, SS | 1 |
| Barnard, EA; Bond, A; Henley, JM | 1 |
| Albensi, BC; Artman, LD; Jackson, H; Jasys, VJ; Mueller, AL; Nemeth, EF; Parks, TN; Saccomano, NA; Volkmann, RA | 1 |
| Jones, MG; Lodge, D; Palmer, AJ | 1 |
| Abbud, R; Smith, MS | 2 |
| Bermudez, J; Chang, XY; Morgan, WW | 1 |
| Supko, DE; Uretsky, NJ; Wallace, LJ | 1 |
| Dure, LS; Penney, JB; Young, AB | 1 |
| Cotman, CW; Koh, JY; Lin, A; Palmer, E | 1 |
| Akaike, N; Ikemoto, Y; Wakamori, M | 1 |
| MacDermott, AB; Reichling, DB | 2 |
| Boksa, P; Chaudieu, I; Mount, H; Quirion, R | 1 |
| Blazynski, C; Linn, DM; Massey, SC; Redburn, DA | 1 |
| Beal, MF; Finn, SF; Kowall, NW; Mazurek, MF; Swartz, KJ | 1 |
| DiMicco, JA; Soltis, RP | 1 |
| Aizenman, E; Lipton, SA; Sucher, NJ | 1 |
| Klunk, WE; McClure, RJ; Pettegrew, JW | 1 |
| Jhamandas, K; Ruzicka, BB | 2 |
| Anderton, PJ; Millar, TJ | 1 |
| Akaike, N; Komune, S; Nakagawa, T; Uemura, T | 1 |
| Arancio, O; MacDermott, AB | 1 |
| Garcia-Ladona, FJ; Girard, C; Gombos, G; Palacios, JM | 1 |
| Bandopadhyay, R; de Belleroche, J | 1 |
| Clark, AJ; Hastings, MH; Latimer, M; Stone, TW; Winn, P | 1 |
| Sapru, H; Sundaram, K | 1 |
| Carter, AJ; Müller, RE | 1 |
| Choi, DW; Koh, JY | 1 |
| Gannon, RL; Terrian, DM | 1 |
| Turner, DA; Wheal, HV | 1 |
| Lai, YY; Siegel, JM | 1 |
| Garyaev, AP; Piotrovsky, LB; Poznyakova, LN | 1 |
| Cubero, A; González-Calero, G; Martín, M | 1 |
| Onodera, K; Takeuchi, A | 1 |
| Lees, GJ; Sandberg, M | 1 |
| Akerman, KE; Holopainen, I; Louve, M | 1 |
| Delrée, P; Lefebvre, PP; Leprince, P; Moonen, G; Rigo, JM; Rogister, B; Weber, T | 1 |
| Eaton, SA; Roberts, WA; Salt, TE | 1 |
| Ham, J; Rickards, C; Scanlon, M | 1 |
| Kollegger, H; McBean, GJ; Tipton, KF | 2 |
| Abe, M; Iino, M; Ozawa, S | 1 |
| Bagust, J; Gardner, CR; Hussain, S; Walker, RJ | 1 |
| Oja, SS; Saransaari, P | 6 |
| Esguerra, M; Kwon, YH; Sur, M | 1 |
| Olney, JW; Pathikonda, M; Snider, WD; Stewart, GR | 1 |
| Coderre, TJ; Melzack, R | 1 |
| Coenen, AM; Peeters, BW; Ramakers, GM; Vossen, JM | 1 |
| Agrawal, AK; Murthy, CR; Rao, VL | 1 |
| Garthwaite, J; Southam, E | 1 |
| Cai, NS; Erdö, SL; Kiss, B | 1 |
| Albuquerque, EX; Alkondon, M; Aronstam, RS; Costa, AC; Radhakrishnan, V | 1 |
| Ohmori, H; Yamaguchi, K | 1 |
| Cull-Candy, SG; Traynelis, SF | 1 |
| Brackley, P; Goodnow, R; Nakanishi, K; Sudan, HL; Usherwood, PN | 1 |
| Dichter, M; Morad, M; Tang, CM | 1 |
| Daló, NL; Larson, AA | 1 |
| McMillian, M; Miller, LG; Schatzki, A | 1 |
| Van der Valk, JB; Vijverberg, HP | 1 |
| Larson, AA; Skilling, SR; Smullin, DH | 1 |
| Cline, HT; Tsien, RW | 1 |
| Hećimović, H; Randić, M; Ryu, PD | 1 |
| Mayer, ML | 1 |
| Krůsek, J; Vlachová, V; Vyklický, L | 1 |
| Guilarte, TR | 1 |
| Gu, YP; Huang, LY | 1 |
| Cowan, A; Larson, AA; Murray, CW | 1 |
| Lovinger, DM; Peoples, RW; Weight, FF; White, G | 1 |
| Colquhoun, D; Cull-Candy, SG; Howe, JR | 1 |
| Greengard, P; Jen, J; Nairn, AC; Stevens, CF | 1 |
| Kline, PA; Nowak, LM; Wright, JM | 1 |
| Akeson, RL; Pruss, RM; Racke, MM; Wilburn, JL | 1 |
| Coyle, JT; Tasker, RC; Vornov, JJ | 1 |
| Larson, AA; Sun, XF | 1 |
| Braquet, P; Chabrier, PE; Demerlé-Pallardy, C; Lonchampt, MO | 1 |
| Franke, C; Hatt, H; Rosenheimer, JL; Smith, DO; Zufall, F | 1 |
| Berge, OG; Hole, K; Lund, A; Mjellem-Joly, N | 1 |
| Arancio, O; MacDermott, AB; Murase, K; Yoshimura, M | 2 |
| Lovinger, DM; Weight, FF; White, G | 2 |
| Adler, H; Albert, DM; Konrad-Rastegar, J; Lessell, S; McGee, TL; Sahel, JA | 1 |
| Albin, RL; Penney, JB; Price, RH; Sakurai, SY; Young, AB | 1 |
| Uretsky, NJ; Wallace, LJ | 1 |
| Corden, M; Curry, K; McLennan, H | 1 |
| Barish, ME; Mansdorf, NB | 1 |
| Arvin, B; Le Peillet, E; Meldrum, BS; Moncada, C | 1 |
| Arnold, MB; Elzey, T; Leander, JD; Lodge, D; Ornstein, PL; Paschal, JW; Schoepp, DD | 1 |
| Durand, J; Ouardouz, M | 1 |
| Leander, JD; Ornstein, PL; Salhoff, CR; Schoepp, DD | 1 |
| Jope, RS; Ormandy, GC; Song, L | 1 |
| Ceccarini, M; Di Stasi, AM; Gallo, V; Petrucci, TC | 1 |
| Gilbertson, TA; Scobey, R; Wilson, M | 1 |
| Brenneman, DE; Markwell, MA; Paul, SM; Sheng, HZ | 1 |
| Erdö, S; Michler, A; Wolff, JR | 1 |
| Budson, AE; Jackson, PS; Lipton, SA | 1 |
| Beitz, AJ; Koerner, JF; Larson, AA; Magnusson, KR; Skilling, SR; Smullin, DH | 1 |
| Calder, LD; Karler, R; Turkanis, SA | 2 |
| Erdö, SL; Keilhoff, G | 1 |
| Beal, MF; Finn, SF; Swartz, KJ | 1 |
| Jope, RS; Ormandy, GC | 1 |
| De Sarro, A; De Sarro, GB; Donato Di Paola, E; Vidal, MJ | 1 |
| Arancio, O; MacDermott, AB; Reichling, DB | 1 |
| Ito, E; Kudo, Y; Ogura, A | 1 |
| Bell, JA; London, ED; Majewska, MD | 1 |
| Ciuffo, GM; Estrada, MR; Jáuregui, EA; Rodríguez, AM | 1 |
| Brehm, L; Jørgensen, FS; Krogsgaard-Larsen, P; Madsen, U; Schaumburg, K | 1 |
| Ziskind-Conhaim, L | 1 |
| Church, J; Lodge, D | 1 |
| Harrison, PH | 1 |
| Glaum, SR; Miller, RJ; Scholz, WK | 1 |
| Cox, JA; Felder, CC; Henneberry, RC | 1 |
| Butterworth, RF; Cotman, CW; Giguere, JF; Peterson, C | 1 |
| Baimbridge, KG; Choi, DW; Koh, J; Weiss, JH | 1 |
| Hestrin, S; Nicoll, RA; Sah, P | 1 |
| Evans, RH; Long, SK; Siarey, RJ; Smith, DA | 1 |
| Ishida, M; Ishihara, T; Nakagawa, Y; Saitoh, K; Shinozaki, H | 1 |
| Nicklas, WJ; Zeevalk, GD | 1 |
| Drewe, JA; Kunze, DL; Miles, R | 1 |
| Dudek, FE; van den Pol, AN; Wuarin, JP | 1 |
| Buso, M; Facci, L; Leon, A; Milani, D; Skaper, SD; Toffano, G | 1 |
| Erdö, SL; Michler, A; Tytko, H; Wolff, JR | 1 |
| Bridges, RJ; Caiozzo, VJ; Gardner, VO; Munden, SK | 1 |
| Nicholson, C; Rice, ME | 1 |
| Meldrum, BS; Smith, SE | 1 |
| Brodfuehrer, PD; Cohen, AH | 1 |
| McMillian, M; Miller, LG; Pritchard, GA | 1 |
| Urca, G; Urca, R | 1 |
| Boos, R; Müller, F; Wässle, H | 1 |
| Chalmers, DT; Dewar, D; Graham, DI; McCulloch, J; Shand, A | 1 |
| Collingridge, GL; Davies, SN | 1 |
| Sansom, MS; Usherwood, PN | 1 |
| Khaspekov, LG; Lisý, V; Stastný, F; Viktorov, IV | 1 |
| Hoehn, K; White, TD | 1 |
| Kerwin, R; Meldrum, B; Patel, S | 1 |
| Bian, XP; Martin, D; Morrisett, RA; Swartzwelder, HS; Wilson, WA | 1 |
| Ehrlich, D; Morgan, IG; Tung, NN | 1 |
| Anis, NA; Jones, MG; Lodge, D | 1 |
| Fink, K; Göthert, M | 1 |
| Birch, PJ; Hayes, AG; Rogers, H | 1 |
| Niemann, W; Stephens, DN; Turski, L | 1 |
| De Barry, J; Mathis, C; Ungerer, A | 1 |
| Fiedler, J; Orrego, F; Villanueva, S | 1 |
| Akaike, N; Murase, K; Nakagawa, T; Randic, M; Shirasaki, T | 1 |
| Sagar, SM | 1 |
| Ikeda, H; Kay, CD; Robbins, J | 2 |
| Colpaert, FC; Koek, W | 1 |
| Hansen, AJ; Honoré, T; Jacobsen, P; Nielsen, EO; Sheardown, MJ | 1 |
| Dutton, GR; Philibert, RA; Rogers, KL | 1 |
| Choi, DW; Hartley, DM; Koh, J; Weiss, JH | 1 |
| Osborne, NN | 1 |
| Keith, RA; Klika, AB; Mangano, TJ; Patel, J; Salama, AI; Zinkand, WC | 1 |
| De Montigny, C; Debonnel, G; Junien, JL; Monnet, FP | 1 |
| Berrino, L; Loffreda, A; Maione, S; Marmo, E; Matera, MG; Vitagliano, S | 1 |
| Courtney, MJ; Lambert, JJ; Nicholls, DG | 1 |
| Mayer, ML; Patneau, DK | 1 |
| Johnson, BG; McQuaid, LA; Schoepp, DD; Smith, EC | 1 |
| Masetto, S; Prigioni, I; Russo, G; Valli, P | 1 |
| Ballanyi, K; Dörner, R; Schlue, WR | 1 |
| Hengerer, B; Leibrock, J; Lindholm, D; Thoenen, H; Zafra, F | 1 |
| Akaike, N; Fukuda, A; Nakagawa, T; Shirasaki, T; Wakamori, M | 1 |
| Balázs, R; Hack, N; Jørgensen, OS | 2 |
| Honoré, T; Imperato, A; Jensen, LH | 1 |
| Akerman, KE; Holopainen, I | 1 |
| Cruz, LJ; Gullak, MF; Mena, EE; Olivera, BM; Pagnozzi, MJ; Richter, KE; Rivier, J | 1 |
| Akita, K; Kudo, Y; Ogura, A | 1 |
| Colpaert, FC; Koek, W; Woods, JH | 1 |
| Herreras, O; Martín del Río, R; Menéndez, N; Sánchez Herranz, A; Solís, JM | 1 |
| Godfraind, JM | 1 |
| Erdö, SL; Michler, A | 1 |
| Attwell, D; Barbour, B; Szatkowski, M | 1 |
| Logan, SD; Spanswick, D | 1 |
| Marchenko, SM | 1 |
| Chung, SK; Cohen, RS; Pfaff, DW | 1 |
| Bernardi, G; Calabresi, P; De Murtas, M; Mercuri, NB | 1 |
| Iino, M; Ozawa, S; Tsuzuki, K | 1 |
| Cotman, CW; Koh, JY; Yang, LL | 1 |
| Dunnett, SB; Isacson, O; Sofroniew, MV | 1 |
| Kulkarni, SK; Mehta, AK; Ticku, MK | 1 |
| Carpenter, DO; Ffrench-Mullen, JM; Hori, N | 1 |
| Michl, J; Ujec, E; Vlachová, V; Vyklický, L; Vyskocil, F | 1 |
| Aanonsen, LM; Wilcox, GL | 3 |
| Fischbach, GD; O'Brien, RJ | 1 |
| MacDonald, JF; Miljkovic, Z; Pennefather, P | 1 |
| Bean, BP; Huettner, JE | 1 |
| Forsythe, ID; Nelson, PG | 1 |
| Cull-Candy, SG; Howe, JR; Ogden, DC | 1 |
| Edwards, C; Krusek, J; Vyklicky, L | 1 |
| Bennett, MV; Kushner, L; Lerma, J; Zukin, RS | 1 |
| Gruol, DL; Joels, M; Yool, AJ | 1 |
| Cull-Candy, SG; Gallo, V; Usowicz, MM | 1 |
| Murase, K; Randic, M; Ryu, PD | 1 |
| Heinemann, S; Hollmann, M; O'Shea-Greenfield, A; Rogers, SW | 1 |
| Ehrlich, D; Sattayasai, J; Zappia, J | 1 |
| Chapman, AG; Dürmuller, N; Lees, GJ; Meldrum, BS | 1 |
| Belaidi, M; Kamenka, JM; Lerner-Natoli, M; N'Gouemo, P; Rondouin, G | 1 |
| Cahill, GM; Menaker, M | 1 |
| Alho, H; Barbaccia, ML; Costa, E; Szekely, AM | 1 |
| Backus, KH; Kettenmann, H; Schachner, M | 1 |
| Bourguignon, JP; Franchimont, P; Gérard, A | 1 |
| Salt, TE | 1 |
| Kegerise, C; Noszek, JC; Siman, R | 1 |
| Bourguignon, JP; Franchimont, P; Gerard, A; Mathieu, J; Simons, J | 1 |
| Ross, SM; Roy, DN; Spencer, PS | 1 |
| Garthwaite, G; Garthwaite, J | 5 |
| Dingledine, R; Kleckner, NW | 1 |
| Cotman, CW; Monaghan, DT; Palmer, E | 2 |
| Curran, T; Hempstead, J; Macgregor-Leon, PF; Mitchelmore, C; Morgan, JI; Sonnenberg, JL | 1 |
| Janssen, PA; Leysen, JE; Pauwels, PJ; Van Assouw, HP | 1 |
| Barish, ME; Sands, SB | 1 |
| de Montigny, C; Debonnel, G; Weiss, M | 1 |
| Caspary, DM; Faingold, CL | 1 |
| Bauce, L; Kemp, DE; Weiss, S | 1 |
| Ito, I; Sugiyama, H; Watanabe, M | 1 |
| McCaslin, PP; Morgan, WW | 2 |
| Leysen, JE; Pauwels, PJ; van Assouw, HP | 1 |
| Fonnum, F; Syvertsen, C | 1 |
| Araneda, R; Bustos, G | 1 |
| Beal, MF; Ferrante, RJ; Kowall, NW; Martin, JB; Swartz, KJ | 1 |
| Dingledine, R; Kleckner, NW; Verdoorn, TA | 1 |
| O'Dell, TJ | 1 |
| Harris, KM; Miller, RJ | 2 |
| Westerberg, E; Wieloch, TW | 1 |
| Miller, RJ; Murphy, SN | 1 |
| Blake, JF; Brown, MW; Collingridge, GL; Yates, RG | 1 |
| Oertel, D; Wickesberg, RE | 1 |
| Brugger, F; Olpe, HR; Pozza, MF; Steinmann, MW | 1 |
| Chapman, B; Miller, KD; Stryker, MP | 1 |
| Beart, PM; Cincotta, M; Summers, RJ | 1 |
| Belhage, B; Bouchelouche, P; Drejer, J; Frandsen, A; Schousboe, A | 1 |
| Bowe, MA; Martin, D; Nadler, JV | 1 |
| Beani, L; Bianchi, C; Jope, RS; Simonato, M | 1 |
| Herranz, AS; Herreras, O; Martín del Río, R; Menéndez, N; Solis, JM | 1 |
| Miyachi, E; Murakami, M | 1 |
| Dubinsky, JM; Rothman, SM; Yamada, KA | 1 |
| Anis, NA; Eldefrawi, AT; Eldefrawi, ME; Gant, DB; Konno, K; Miledi, R; Ragsdale, D | 1 |
| Johnson, BG; Schoepp, DD | 1 |
| Bieger, D; Hashim, MA | 1 |
| Dye, J; Heiligenberg, W; Kawasaki, M; Keller, CH | 1 |
| Bredt, DS; Snyder, SH | 1 |
| Keith, RA; Mangano, TJ; Salama, AI | 1 |
| Hornfeldt, CS; Larson, AA | 1 |
| Brunori, A; Mayer, ML; Sugiyama, K | 1 |
| Mayer, ML; Westbrook, GL | 3 |
| Turski, WA | 1 |
| Friedemann, M; Gerhardt, GA | 1 |
| Barrington, M; Ehrlich, D; Sattayasai, J; Zappia, J | 1 |
| Acuff, CG; Clower, BR; Rockhold, RW | 1 |
| Talman, WT | 2 |
| Shreve, PE; Uretsky, NJ | 3 |
| Bustos, G; Rudolph, MI | 1 |
| Drejer, J; Honoré, T | 1 |
| Aizenman, E; Karschin, A; Lipton, SA | 1 |
| Schmidt, CJ; Taylor, VL | 1 |
| Jacquet, YF; Squires, RF | 1 |
| Jacquet, YF | 1 |
| Meldrum, BS; Millan, MH; Patel, S | 1 |
| Noszek, JC; Siman, R | 1 |
| Harrison, NL; Simmonds, MA | 1 |
| Bloomfield, SA; Dowling, JE | 1 |
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| Capobianco, A; Comoletti, D; Mennini, T; Muzio, V; Ravizza, T | 1 |
| Calaza, KC; de Mello, FG; Gardino, PF | 1 |
| Fretto, G; Li Volsi, G; Licata, F; Mauro, MD; Santangelo, F | 1 |
| Baba, M; Ikegaya, Y; Iwatsubo, T; Kim, JA; Matsuki, N; Nishiyama, N | 1 |
| Iadecola, C; Kazama, K; Niwa, K; Ross, ME; Sugimoto, K | 1 |
| Asai, S; Ishikawa, K; Kanematsu, K; Kohno, T; Kunimatsu, T; Misaki, T | 1 |
| Aihara, H; Kanno, T; Kodama, N; Kondoh, T; Matsumoto, S; Nagai, K; Nagata, T; Nishizaki, T; Nomura, T; Ohta, K; Saito, N; Tozaki, H; Yajima, Y | 1 |
| Gmiro, VE; Gorbunova, LV; Lukomskaia, NIa; Rukoiatkina, NI | 1 |
| Attwell, D; Hamann, M; Marie, H; Rossi, DJ | 1 |
| Dohovics, R; Hermann, A; Janáky, R; Oja, SS; Saransaari, P | 1 |
| Jang, YP; Kim, SR; Kim, YC; Markelonis, GJ; Oh, TH; Sung, SH | 1 |
| Fujinami, Y; Kitano, M; Ogita, K; Okuda, H; Ozaki, K; Yoneda, Y | 1 |
| Manabe, T; Nakamichi, N; Yoneda, Y | 1 |
| Aguilar, E; González, LC; Pinilla, L; Tena-Sempere, M | 1 |
| Choi, YH; Jang, YP; Kim, J; Kim, SG; Kim, SR; Kim, YC; Markelonis, GJ; Oh, TH | 1 |
| Mayhan, WG; Patel, KP; Sun, H | 1 |
| Baille, V; Bockaert, J; De Bock, F; Djebaïli, M; Rondouin, G | 1 |
| Haugvicová, R; Kubová, H; Mares, P | 1 |
| Soria, JM; Valdeolmillos, M | 1 |
| Bai, D; Muller, RU; Roder, JC | 1 |
| Carpenter, DO; Hori, N; Strominger, NL; Tan, Y | 1 |
| Lisý, V; Stastný, F | 1 |
| Fujimori, S; Hinoi, E; Takarada, T; Taniura, H; Yoneda, Y | 1 |
| Chan, JY; Lo, WC; Tseng, CJ; Tung, CS | 1 |
| Fischer, AJ; Reh, TA | 1 |
| Dohovics, R; Hermann, A; Janáky, R; Oja, SS; Saransaari, P; Varga, V | 1 |
| Ogita, K; Okuda, H | 1 |
| Brown, JJ; Bushman, SM; Pszczolkowski, MA; Zahand, A | 1 |
| Colonnese, MT; Constantine-Paton, M; Shi, J | 1 |
| Chidlow, G; Osborne, NN | 1 |
| Bladin, C; Liberatore, GT; Medcalf, RL; Samson, A; Schleuning, WD | 1 |
| Billingsley, ML; Boyer, PJ; Erin, N; Lehman, RA | 1 |
| Qin, YH; Song, LH; Wang, L; Zhang, HS | 1 |
| Ha, HJ; Kim, HC; Kwon, MS; Kwon, YS; Park, JH; Park, SM; Shin, T; Wie, MB | 1 |
| Nishiyama, N; Ogita, K; Okuda, H; Yamamoto, Y; Yoneda, Y | 1 |
| Gmiro, VE; Gorbunova, LV; Lukomskaya, NY; Rukoyatkina, NI | 1 |
| Habaguchi, T; Ohtinata-Sugimoto, J; Saitoh, K; Sakamoto, T; Takakusaki, K | 1 |
| An, HG; Kim, CH; Kim, HM; Ko, JH; Koo, BS; Lee, YC; Moon, SK | 1 |
| Laube, B; Ortinau, S; Zimmermann, H | 1 |
| Maruo, K; Maruo, S; Nagai, K; Nagata, T; Nishizaki, T; Yajima, Y; Yamamoto, S | 1 |
| Campbell, IL; Criado, J; Henriksen, SJ; Huitron-Resendiz, S; Masliah, E; Samland, H | 1 |
| Akaike, A; Honda, Y; Kashii, S; Ujihara, H; Yamauchi, T; Yasuyoshi, H; Zhang, S | 1 |
| Choi, DW; Lee, CS; Macdonald, ME; Moss, JL; Revilla, FJ; Snider, BJ; Wheeler, VC | 1 |
| Facci, L; Skaper, SD; Stevens, DA | 1 |
| Calaza, Kda C; de Mello, FG; de Mello, MC; Gardino, PF | 1 |
| Choi, L; Girgis, R; Gottlieb, DI; Lee, CS; Lewis, B; Liu, S; Lu, A; McDonald, JW; Qu, Y; Snider, BJ; Vadivelu, S | 1 |
| Gilliams-Francis, KL; Naegele, JR; Quaye, AA | 1 |
| Cosi, C; Guerin, K; Koek, W; Marien, M; Rollet, K | 1 |
| Awe, SO; Harris, LC; Kulkarni, K; LeDay, AM; Ohia, SE; Opere, CA; Sharif, NA | 1 |
| Bachurin, SO; Dranyi, OA; Grigorev, VV | 1 |
| Benz, B; Binns, KE; Do, KQ; Eaton, SA; Salt, TE | 1 |
| De Mello, FG; Ferreira, ST; Louzada, PR; Mendonca-Silva, DL; Noël, F; Paula Lima, AC | 1 |
| Bae, CD; Jeon, S; Kim, EG; Kim, SJ; Park, J; Shin, EY | 1 |
| Morciano, M; Ortinau, S; Zimmermann, H | 1 |
| Banerjee, M; Kaminski, RM; Rogawski, MA | 1 |
| Alonso, TJ; Castro Fuentes, R; García Dopico, J; González Hernández, T; Perdomo Díaz, J; Rodríguez Díaz, M | 1 |
| Bol'shakov, KV; Gmiro, VE; Gorbunova, LV; Lukomskaya, NY; Magazanik, LG; Rukoyatkina, NI | 1 |
| Corona, JC; Tapia, R | 1 |
| Grebenyuk, S; Kirichok, Y; Krishtal, O; Lozovaya, N; Melnik, S; Tsintsadze, T | 1 |
| Alt, AJ; Bleakman, D; Bortolotto, ZA; Buelens, FP; Clarke, VR; Collingridge, GL; Dolman, NP; Jane, DE; Kelland, EE; More, JC; Nistico, R; Ogden, AM; Pilato, F; Troop, HM | 1 |
| André, N; Gillardin, JM; Heulard, I; Verleye, M | 1 |
| Begtrup, M; Bräuner-Osborne, H; Calí, P; Clausen, RP; Egebjerg, J; Greenwood, JR; Hansen, KB; Nielsen, B | 1 |
| Guy, Y; Jilderos, B; Sandberg, M; Stridh, MH; Tranberg, M; Weber, SG; Wigström, H | 1 |
| Hara, A; Kozawa, O; Kumada, M; Matsuno, H; Matsuo, O; Mori, H; Niwa, M; Wang, X; Yamamoto, T | 1 |
| Bringmann, A; Klaus, C; Reichenbach, A; Rillich, K; Syková, E; Uckermann, O; Ulbricht, E; Vargová, L; Weick, M; Wiedemann, P | 1 |
| Balthazart, J; Cornil, CA; Motte, P; Seutin, V | 1 |
| Henley, JM; Martin, S | 1 |
| Baba, A; Luo, X; Matsuda, T; Romano, C | 1 |
| Cheung, HH; Gillard, ER; Gurd, JW; Khan, AM; Palarca, JA; Stanley, BG; Welsbie, DS | 1 |
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| Berezov, T; Boldyrev, A; Carpenter, DO; Koudinov, A | 1 |
| Akopian, G; Andersen, JK; Boonplueang, R; Kuhlenkamp, JF; Lu, SC; Stevenson, FF; Walsh, JP | 1 |
| Bennett, SA; Cheung, EC; Cregan, SP; Ferguson, KL; McIntosh, WC; Melanson-Drapeau, L; Park, DS; Slack, RS; Vanderluit, JL | 1 |
| Díaz-Trelles, R; Fernández-Sánchez, MT; Groppetti, A; Novelli, A | 1 |
| Bai, D; Frandsen, A; Gong, XQ; Lu, WY; Pickering, DS; Wan, Y; Zabek, RL | 1 |
| Nagashima, R; Ogita, K; Okuda, H; Sugiyama, C; Watanabe, M; Yoneda, Y | 1 |
| Ampo, K; Kadono, C; Kiryu-Seo, S; Kiyama, H; Konishi, H; Maeda, M; Ohba, N | 1 |
| Alzheimer, C; Kovalev, G; Schibaev, N; Vorobyov, V | 1 |
| Chergui, K; Greengard, P; Svenningsson, P | 1 |
| Araie, M; Fukaya, Y; Kashwagi, K; Ohashi, M; Saito, S; Suzuki, Y; Tomidokoro, A | 1 |
| Buzanska, L; Domanska-Janik, K; Salvi, RJ; Stachowiak, MK; Sun, W | 1 |
| Onoda, N; Sugai, T | 1 |
| Kartelija, G; Radenović, L; Selaković, V | 1 |
| Baillien, M; Ball, GF; Balthazart, J | 1 |
| Rokyta, R; Slamberová, R | 1 |
| Kalloniatis, M; Sun, D | 1 |
| Akasofu, S; Kimura, M; Kosasa, T; Ogura, H; Sawada, K | 1 |
| Anrather, J; Cho, S; Frys, KA; Iadecola, C; Kawano, T; Kunz, A; Orio, M; Park, L; Wang, G; Zhou, P | 1 |
| Kanno, T; Maruo, K; Maruo, S; Nishizaki, T; Yaguchi, T; Yamamoto, S; Yashiya, S | 1 |
| Gobbi, G; Janiri, L | 1 |
| Georgescu, M; Pfaus, JG | 1 |
| Calixto, JB; Gadotti, VM; Paszcuk, AF; Rodrigues, AL; Santos, AR; Tibola, D | 1 |
| Joshi, NB; Joshi, PG; Sanganahalli, BG | 1 |
| Bremner, P; Gibbons, S; Heinrich, M; Jacobo-Herrera, NJ; Koistinaho, J; Vartiainen, N | 1 |
| Crochet, S; Onoe, H; Sakai, K | 1 |
| Lukomskaya, NY; Magazanik, LG; Tikhonov, DB; Tikhonova, TB | 1 |
| Henry, M; Hescheler, J; Radhakrishnan, K; Schneider, T; Weiergräber, M | 1 |
| Dai, Q; Gao, R; Meng, H; Qiao, X | 1 |
| Andrianov, GN; Nozdrachev, AD; Ryzhova, IV | 1 |
| Kang, SY; Kim, YC | 1 |
| Collis, LP; Kreitzer, MA; Malchow, RP; Molina, AJ; Smith, PJ | 1 |
| Duance, V; Flood, S; Mason, D; Parri, R; Williams, A | 1 |
| Jakovljevic, M; Jankovic, SM; Jankovic, SV; Milovanovic, D; Stojadinovic, D | 1 |
| Soltesz, I; Szabadics, J; Tamás, G | 1 |
| Furuta, K; Ito, S; Mabuchi, T; Maeda, M; Minami, T; Soen, M; Suzuki, M; Tatsumi, S | 1 |
| Arrick, DM; Mayhan, WG | 1 |
| Blizzard, CA; Chuah, MI; Chung, RS; Dickson, TC; Foster, SS; King, AE; Vickers, JC; West, AK | 1 |
| Arrick, DM; Mayhan, WG; Sharpe, GM; Sun, H | 1 |
| Aono, S; Hayakawa, M; Ida, M; Kakizawa, H; Kojima, S; Kuroda, Y; Maeda, H; Matsui, F; Nakanishi, K; Oohira, A; Saito, A; Sato, Y; Tokita, Y | 1 |
| Casson, RJ; Chidlow, G; Manavis, J; Osborne, NN; Wood, JP | 1 |
| Brines, M; Cerami, A; Divoux, D; Ghezzi, P; Mengozzi, M; Petit, E; Probert, L; Quackenbush, J; Roberts, ML; Taoufik, E; Tseveleki, V; Valable, S | 1 |
| Kass-Simon, G; Scappaticci, AA | 1 |
| Akaike, A; Hama, Y; Katsuki, H; Kume, T; Suminaka, C | 1 |
| Margaryan, G; Mladinic, M; Nistri, A; Taccola, G | 1 |
| Antonov, SM; Dvoretskova, EA; Evstratova, AA; Mironova, EV | 2 |
| Bosetti, F; Kingsley, PJ; Marnett, LJ; Toscano, CD | 1 |
| Bouschet, T; Henley, JM; Jenkins, EL; Martin, S; Nishimune, A | 1 |
| Denbow, DM; Furuse, M; Tsuneyoshi, Y; Yamane, H | 1 |
| Chen, HH; Duquette, PM; Harper, ME; Lewandowski, AJ; Qin, Z; Rai, PS; Schock, SC; Seifert, EL; Thompson, CS; Xu, J | 1 |
| Al-Sarraf, H; Krajci, D; Mohammadi, S; Pavlik, A | 1 |
| Di Cosmo, A; Di Cristo, C; Moccia, F; Winlow, W | 1 |
| Feligioni, M; Henley, JM; Nishimune, A | 1 |
| Clarke, PG; Rummel, C; Vaslin, A | 1 |
| Brunet, N; Calderó, J; Esquerda, JE; Tarabal, O | 1 |
| Jantas, D; Jaworska-Feil, L; Lason, W; Lipkowski, AW | 1 |
| D'Arcangelo, G; Frank, C; Grossi, D; Luly, P; Rufini, S; Tancredi, V | 1 |
| Iwata, Y; Jonas, RA; Nicole, O; Okamura, T; Zurakowski, D | 1 |
| Godlevskii, LS; Kobolev, EV; Kresyun, VI | 1 |
| Chou, CL; Kasanuki, JM; Nagasaki, T; Tosi, J; Tsang, SH; Wang, NK; Zhao, J | 1 |
| Baldwin, RA; Jäger, AK; Niquet, J; Pedersen, ME; Stafford, GI; van Staden, J; Wasterlain, CG | 1 |
| Kubová, H; Mares, P; Tchekalarova, J | 1 |
| Akaike, H; Akaike, N; Hori, N; Ito, Y; Jang, II; Ogawa, S | 1 |
| Garcia-Rill, E; Hayar, A; Hyde, J; Kezunovic, N; Simon, C; Williams, DK; Ye, M | 1 |
| Bansod, K; Bhutada, P; Dixit, P; Mundhada, D; Mundhada, Y; Umathe, S | 1 |
| Azizi, N; Lindstrom, SH; Weller, C; Wilson, M | 1 |
| Huang, L; Li, L; Li, P; Li, X; Li, Y; Ray, J; Wang, X | 1 |
| Balduzzi, M; Bellenchi, GC; Cammarota, R; Carnovale-Scalzo, G; De Nuccio, C; Di Stasi, AM; Frank, C; Leo, L; Malchiodi-Albedi, F; Mallozzi, C; Matteucci, A; Paradisi, S; Scorcia, G; Varano, M; Visentin, S | 1 |
| Bernard, H; Charpier, S; David, O; Depaulis, A; Deransart, C; Langlois, M; Polack, PO | 1 |
| Ahmad, AS; Doré, S; Lopez, PH; Mehta, NR; Rowland, EA; Schnaar, RL; Toner, M; Zhang, J | 1 |
| Beleboni, RO; Cunha, AO; dos Santos, WF; Fachim, HA; Faggion, SA; Gavin, AS; Pereira, AM | 1 |
| Kaptsov, V; Kovalev, G; Schibaev, N; Sengpiel, F; Vorobyov, V | 1 |
| Garcia-Rill, E; Hayar, A; Simon, C | 2 |
| Beleboni, RO; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Fachim, HA; Gobbo-Neto, L; Lopes, NP; Pereira, AC | 1 |
| Furuya, T; Kashiwagi, K; Pan, Z | 1 |
| Basuroy, S; Fedinec, AL; Leffler, CW; Liu, J; Parfenova, H; Tcheranova, D | 1 |
| Contó, MB; Venditti, MA | 1 |
| Auger, C; Cais, O; Corrie, JE; Cowell, JK; Crawford, DJ; Hodgson, AC; Ogden, D; Palma-Cerda, F; Reynolds, SJ; Swift, KA; Vyklicky, L | 1 |
| Han, W; Qi, J; Song, M; Wang, F; Wu, C; Yang, J; Zhang, L; Zhao, S | 1 |
| Kalinina, NI; Kurchavyĭ, GG; Veselkin, NP | 1 |
| Abushik, PA; Antonov, SM; Bolshakov, AE; Krivoi, II; Sibarov, DA | 1 |
| Bachurin, SO; Gabrelian, AV; Grigoriev, VV; Petrova, LN; Serkova, TP; Zamoyski, VL | 1 |
| Godlevsky, LS; Godovan, VV; Kresyun, VI; Polyasny, VA | 1 |
| Chen, X; Hu, W; Xiao, G | 1 |
| Ayalon, G; Bustos, D; Gogineni, A; Hanson, JE; Jubb, AM; Kirkpatrick, DS; Larson, JL; Lee, SH; Lewcock, JW; Li, H; Ngu, H; Pozniak, CD; Scearce-Levie, K; Sengupta Ghosh, A; Solanoy, H; Weimer, RM; Wu, J; Zhou, Q | 1 |
| Choi, DJ; Choi, I; Jeong, HK; Ji, KM; Joe, EH; Jou, I; Min, KJ | 1 |
| Gmiro, VE; Serdyuk, SE; Veselkina, OS | 1 |
| Fukushima, K; Imaizumi, Y; Ito, M; Kohmura, N; Sawada, K; Sugawara, M; Tabata, Y; Yamazaki, K | 1 |
| Youssef, FF | 1 |
| Calaza, KC; de Mello, FG; Gardino, PF; López-Bayghen, E; Mendez-Flores, OG; Ornelas, I; Ortega, A; Pérez-Toledo, K; Reis, RA; Santos, LE; Schitine, CS | 1 |
| Chara, JC; Cipriani, R; Matute, C; Rodríguez-Antigüedad, A | 1 |
| Smothers, CT; Szumlinski, KK; Woodward, JJ; Worley, PF | 1 |
| Butman, JA; Suga, N | 1 |
| Kaur, J; Nistri, A; Sámano, C | 1 |
| Barnstable, CJ; Horvath, TL; Li, H; Reddy, R | 1 |
| Bhattarai, JP; Bhattarai, P; Han, SK; Kim, MS | 1 |
| Huettner, JE; Lopez, MN; Wilding, TJ | 1 |
| Hayashi, Y; Takahashi, M; Tanaka, J | 1 |
| Sheets, L | 1 |
| Araki, K; Higashiyama, S; Inamura, N; Iwakura, Y; Nawa, H; Takei, N; Wang, R | 1 |
| Asahara, H; Fukaya, M; Hagiwara, M; Kobayashi, S; Komano-Inoue, S; Manabe, H; Manabe, T; Mizuguchi, M; Murakami, T; Ogonuki, N; Ogura, A; Okuda, K; Sakagami, H; Sato, T; Tanaka, T; Ueno, H; Watanabe, A; Yamaguchi, M | 1 |
| Avendaño, C; Fernández-Montoya, J; Negredo, P | 1 |
| Asaka, N; Kishimoto, I; Kita, T; Matsunaga, M; Nakagawa, T; Omori, K; Yamahara, K; Yamamoto, N | 1 |
| Chang, WK; Gan, YL; Hsu, PC; Hu, YY; Huang, YJ; Hung, CC; Kao, LS; Kuo, YM; Lee, YH; Lin, CH; Shie, FS; Tsou, MY | 1 |
| Eyigor, O; Gok-Yurtseven, D; Kafa, IM; Minbay, Z | 1 |
| Bading, H; Bas-Orth, C; Buchthal, B; Koch, M; Lau, D | 1 |
| Calvo, E; Cuenca, N; De la Villa, P; Germain, F; Gómez-Vicente, V; Milla-Navarro, S; Ortuño-Lizarán, I | 1 |
| Ábrahám, IM; Cho, DH; Han, SK; Jang, SH; Park, SA; Rijal, S | 1 |
| Brüll, M; Falt, T; Karreman, C; Klima, S; Leist, M; Schwamborn, JC; Spreng, AS; Suciu, I; Waldmann, T | 1 |
| Collingridge, GL; Monaghan, DT | 1 |
| Chang, A; Chang, Y; Wang, SJ | 1 |
20 review(s) available for n-methylaspartate and kainic acid
| Article | Year |
|---|---|
The role of receptor binding in drug discovery.
Topics: Animals; Drug Design; Humans; Receptors, Drug | 1993 |
Evidence for hybrid NMDA/kainate receptors from protein reconstitution studies and expression of vertebrate CNS RNAs in Xenopus oocytes.
Topics: Animals; Chromatography, Affinity; Glycine; Ion Channel Gating; Kainic Acid; N-Methylaspartate; Oocytes; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Xenopus laevis | 1992 |
Alcohol and anesthetic actions on excitatory amino acid-activated ion channels.
Topics: Alcohols; Anesthetics; Animals; Ethanol; Evoked Potentials; Hippocampus; In Vitro Techniques; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid | 1991 |
Alcohol inhibition of NMDA channel function.
Topics: Alcohols; Animals; Brain; Cell Membrane; Ethanol; Evoked Potentials; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate | 1991 |
Effect of GABAergic and glutamatergic drugs injected into the ventral pallidum on locomotor activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamine; Animals; gamma-Aminobutyric Acid; Globus Pallidus; Glutamates; Ibotenic Acid; Kainic Acid; Motor Activity; Muscimol; N-Methylaspartate; Picrotoxin | 1991 |
Mechanisms underlying excitatory amino acid-evoked calcium entry in cultured neurons from the embryonic rat spinal cord.
Topics: Amino Acids; Animals; Calcium; Cells, Cultured; Kainic Acid; N-Methylaspartate; Neurons; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord | 1990 |
Quinoxalinediones as excitatory amino acid antagonists in the vertebrate central nervous system.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Binding, Competitive; Central Nervous System; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Membrane Potentials; N-Methylaspartate; Quinoxalines; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Signal Transduction; Spinal Cord; Structure-Activity Relationship; Vertebrates | 1990 |
Single-channel studies of glutamate receptors.
Topics: Animals; Anions; Astacoidea; Cations, Divalent; Electrophysiology; Glutamates; Glutamic Acid; Glycine; Grasshoppers; Hippocampus; Ibotenic Acid; Invertebrates; Ion Channel Gating; Kainic Acid; Membrane Potentials; Models, Biological; N-Methylaspartate; Neuromuscular Junction; Neurotransmitter Agents; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship; Synaptic Transmission; Vertebrates | 1990 |
In vivo regulation of extracellular taurine and other neuroactive amino acids in the rabbit hippocampus.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Ethanolamines; Extracellular Space; Hippocampus; Iodoacetates; Iodoacetic Acid; Ischemia; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Potassium; Rabbits; Taurine | 1985 |
The physiology of excitatory amino acids in the vertebrate central nervous system.
Topics: Amino Acids; Animals; Aspartic Acid; Central Nervous System; Glutamates; Glutamic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Vertebrates | 1987 |
Pharmacology of excitatory amino acid transmitters.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Glutamate | 1981 |
The stimulation of ion fluxes in brain slices by glutamate and other excitatory amino acids.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Biological Transport, Active; Brain; Calcium; Cations; Cell Membrane Permeability; Glutamates; Glutamic Acid; In Vitro Techniques; Ion Channels; Kainic Acid; Kinetics; N-Methylaspartate; Potassium; Rubidium; Sodium; Sodium-Potassium-Exchanging ATPase | 1981 |
Ethanol action on excitatory amino acid activated ion channels.
Topics: Animals; Brain; Cells, Cultured; Ethanol; Excitatory Amino Acids; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid | 1993 |
[Receptive mechanisms of excitatory amino acid signals].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain Ischemia; Epilepsy; Ibotenic Acid; Kainic Acid; Ligands; N-Methylaspartate; Receptors, Amino Acid; Signal Transduction; Transcription Factors | 1993 |
Excitatory amino acid neurotoxicity in the developing brain.
Topics: Animals; Brain; Brain Ischemia; Dizocilpine Maleate; Humans; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1993 |
Glutamatergic transmission in the nucleus tractus solitarii: from server to peripherals in the cardiovascular information superhighway.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Baroreflex; Cardiovascular Physiological Phenomena; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Kainic Acid; N-Methylaspartate; Receptors, Glutamate; Solitary Nucleus | 1997 |
Excitotoxic mechanisms of neurodegeneration in transmissible spongiform encephalopathies.
Topics: Animals; Brain; Cricetinae; Glutamic Acid; Humans; Hypothalamus; Ibogaine; Kainic Acid; Mice; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Prion Diseases | 1997 |
[Stimulating amino acids in epilepsy: possibilities of treatment].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anticonvulsants; Asparagine; Epilepsy; Female; Glutamine; Humans; Kainic Acid; Male; N-Methylaspartate; Synaptic Transmission | 2000 |
[Protective effects of N-methyl-D-aspartate against neuronal damages].
Topics: Animals; Cell Death; Cells, Cultured; Excitatory Amino Acid Agonists; Glutamates; Humans; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate | 2002 |
The Glutamatergic System in Primary Somatosensory Neurons and Its Involvement in Sensory Input-Dependent Plasticity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ganglia, Sensory; Glutamic Acid; Humans; Kainic Acid; N-Methylaspartate; Neuralgia; Neuronal Plasticity; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Sensory Receptor Cells; Synaptic Transmission | 2017 |
1228 other study(ies) available for n-methylaspartate and kainic acid
| Article | Year |
|---|---|
Synthesis and bioactivity of a new class of rigid glutamate analogues. Modulators of the N-methyl-D-aspartate receptor.
Topics: Animals; Azetidinecarboxylic Acid; Azetines; Calcium; Cells, Cultured; Cerebellum; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship | 1990 |
Synthesis, resolution, and absolute configuration of the isomers of the neuronal excitant 1-amino-1,3-cyclopentanedicarboxylic acid.
Topics: Amino Acids; Animals; Circular Dichroism; Crystallization; Cycloleucine; Hippocampus; Isomerism; Neurons | 1988 |
Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.
Topics: Animals; Bridged Bicyclo Compounds; Calcium; Cells, Cultured; Cerebellum; CHO Cells; Cricetinae; Cyclic AMP; Cycloleucine; Dicarboxylic Acids; Excitatory Amino Acid Agonists; Glutamic Acid; Inositol Phosphates; Kidney; Ligands; Models, Molecular; Molecular Conformation; Norbornanes; Rats; Receptors, Metabotropic Glutamate; Stereoisomerism | 1998 |
Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists.
Topics: Animals; Cerebral Cortex; Convulsants; Excitatory Amino Acid Agonists; In Vitro Techniques; Isoxazoles; Male; Mice; Mice, Inbred DBA; Models, Molecular; Molecular Conformation; Proline; Pyrroles; Radioligand Assay; Rats; Receptors, AMPA; Receptors, Kainic Acid; Stereoisomerism | 1999 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues.
Topics: Amino Acids, Acidic; Animals; Brain; Cell Line; Chromatography, High Pressure Liquid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; In Vitro Techniques; Male; Oocytes; Oxadiazoles; Patch-Clamp Techniques; Potentiometry; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Xenopus laevis | 2010 |
Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Excitatory Amino Acid Agonists; HEK293 Cells; Humans; Ligands; Rats; Receptors, AMPA; Synaptosomes; Triazoles | 2019 |
Excitatory amino acid receptors and synaptic excitation in the mammalian central nervous system.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Glutamates; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Neurotransmitter; Spinal Nerve Roots | 1979 |
Excitatory amino acid-mediated responses and synaptic potentials in medial pontine reticular formation neurons of the rat in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Electrophysiology; Female; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Neurons; Pons; Rats; Rats, Inbred Strains; Reticular Formation; Synapses | 1992 |
Preferential activation of [3H]phorbol-12,13-dibutyrate binding by AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) in neonatal striatal cell cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Binding Sites; Cells, Cultured; Corpus Striatum; Cycloleucine; Glial Fibrillary Acidic Protein; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neurotoxins; Phorbol 12,13-Dibutyrate; Phosphopyruvate Hydratase; Rats; Rats, Inbred F344 | 1992 |
Time course of glutamate receptor expression in individual oocytes of Xenopus laevis after injection of rat brain RNA.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Electrophysiology; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Oocytes; Quisqualic Acid; Rats; Receptors, Glutamate; RNA, Messenger; Xenopus laevis | 1992 |
Amino terminus of substance P potentiates kainic acid-induced activity in the mouse spinal cord.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Exploratory Behavior; Glycopeptides; Injections, Spinal; Kainic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Peptide Fragments; Spinal Cord; Substance P | 1992 |
Stereoselective effects of AMOA on non-NMDA receptors expressed in Xenopus oocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Dose-Response Relationship, Drug; Female; Ibotenic Acid; Isoxazoles; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Oocytes; Propionates; Receptors, Amino Acid; RNA, Messenger; Stereoisomerism; Xenopus laevis | 1992 |
Expression of NMDA channels on cerebellar Purkinje cells acutely dissociated from newborn rats.
Topics: Animals; Animals, Newborn; In Vitro Techniques; Ion Channels; Kainic Acid; N-Methylaspartate; Purkinje Cells; Rats; Receptors, N-Methyl-D-Aspartate | 1992 |
Evidence that [3H]glutamate binding sites are masked by biologically relevant endogenous factor on cell membranes of frog spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Cell Membrane; Cytosol; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Kinetics; Membrane Potentials; N-Methylaspartate; Piperazines; Quisqualic Acid; Rana catesbeiana; Spinal Cord | 1992 |
Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Arginine; Cycloleucine; Hemoglobins; Hydroxylamine; Hydroxylamines; Hyperalgesia; Ibotenic Acid; Injections, Spinal; Kainic Acid; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Spinal Cord; Time Factors | 1992 |
Alterations in [3H]kainate and N-methyl-D-aspartate-sensitive L-[3H]-glutamate binding in the rat hippocampal formation following fimbria-fornix lesions.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Autoradiography; Female; Glutamates; Hippocampus; Kainic Acid; N-Methylaspartate; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reference Values; Tritium | 1992 |
Ethanol attenuates the response of locus coeruleus neurons to excitatory amino acid agonists in vivo.
Topics: Acetylcholine; Adrenergic Fibers; Amino Acids; Animals; Ethanol; Glutamates; Kainic Acid; Locus Coeruleus; Male; N-Methylaspartate; Norepinephrine; Quisqualic Acid; Rats; Rats, Inbred Strains; Synaptic Transmission | 1992 |
Nitric oxide does not mediate the neurotrophic effects of excitatory amino acids in cultured cerebellar granule neurons.
Topics: Animals; Arginine; Cell Survival; Cells, Cultured; Cerebellum; Cyclic GMP; Drug Stability; Kainic Acid; N-Methylaspartate; Nitric Oxide; Nitroarginine; Penicillamine; Rats; Rats, Inbred Strains; S-Nitroso-N-Acetylpenicillamine | 1992 |
Inhibition of N-methyl-D-aspartate- and kainate-evoked noradrenaline release in human cerebral cortex slices by ethanol.
Topics: Adult; Cerebral Cortex; Drug Interactions; Ethanol; Female; Humans; Kainic Acid; Male; N-Methylaspartate; Norepinephrine; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Veratridine | 1992 |
Excitatory amino acid signal transduction in the hippocampus: role of noradrenergic afferents and nitric oxide in cGMP increases in vivo.
Topics: Analysis of Variance; Animals; Cyclic GMP; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Nitric Oxide; Norepinephrine; Quisqualic Acid; Rats; Rats, Inbred Strains; Signal Transduction | 1992 |
Burst firing in dopamine neurons induced by N-methyl-D-aspartate: role of electrogenic sodium pump.
Topics: Action Potentials; Animals; Cells, Cultured; Dopamine; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Sodium; Sodium-Potassium-Exchanging ATPase; Synaptic Transmission | 1992 |
The antinociceptive activity of excitatory amino acids in the rat brainstem: an anatomical and pharmacological analysis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Mapping; Brain Stem; Diencephalon; Dizocilpine Maleate; Female; Glutamates; Glutamic Acid; Kainic Acid; Male; Medulla Oblongata; Mesencephalon; Microinjections; N-Methylaspartate; Pain; Periaqueductal Gray; Quisqualic Acid; Rats; Rats, Inbred Strains; Reticular Formation; Stereotaxic Techniques | 1992 |
The effects of excitatory amino acids on proenkephalin and prodynorphin mRNA levels in the hippocampal dentate gyrus of the rat; an in situ hybridization study.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Enkephalins; Functional Laterality; Gene Expression; Hippocampus; Kainic Acid; Kinetics; Male; Microinjections; N-Methylaspartate; Nucleic Acid Hybridization; Protein Precursors; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; RNA, Messenger | 1992 |
Excitatory amino acid regulation of gonadotropin secretion: modulation by steroid hormones.
Topics: Animals; Estradiol; Female; Follicle Stimulating Hormone; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Luteinizing Hormone; N-Methylaspartate; Ovariectomy; Radioimmunoassay; Rats; Time Factors | 1992 |
Kindling-induced long-lasting changes in synaptic transmission in the basolateral amygdala.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Amygdala; Animals; Bicuculline; Electric Stimulation; Kainic Acid; Kindling, Neurologic; Male; N-Methylaspartate; Neurons; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synapses; Synaptic Transmission | 1992 |
L-proline activates glutamate and glycine receptors in cultured rat dorsal horn neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cells, Cultured; Female; Glutamates; Glycine; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Pregnancy; Proline; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Glycine; Receptors, Neurotransmitter; Spinal Cord; Strychnine | 1992 |
Evidence that non-NMDA receptors are involved in the excitatory pathway from the pedunculopontine region to nigrostriatal dopaminergic neurons.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Corpus Striatum; Dopamine; Electric Stimulation; Evoked Potentials; Glutamine; Iontophoresis; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Neurons; Pons; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Synapses | 1992 |
Serotonin1A facilitation of frog motoneuron responses to afferent stimuli and to N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; 8-Hydroxy-2-(di-n-propylamino)tetralin; Afferent Pathways; Animals; Electric Stimulation; Evoked Potentials; Glycine; In Vitro Techniques; Kainic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Nerve Fibers; Quisqualic Acid; Rana pipiens; Serotonin; Spinal Cord; Spinal Nerve Roots; Tetrahydronaphthalenes; Tetrodotoxin; Tropanes | 1992 |
L-serine-O-phosphate blocks NMDA-evoked responses in the ampullae of Lorenzini of skates.
Topics: Amino Acids; Animals; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons, Afferent; Phosphoserine; Quisqualic Acid; Skates, Fish; Synapses; Synaptic Transmission | 1992 |
Calcium excitability and oscillations in suprachiasmatic nucleus neurons and glia in vitro.
Topics: Animals; Animals, Newborn; Astrocytes; Axons; Calcium; Cells, Cultured; Cytoplasm; Fura-2; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamates; Glutamic Acid; Immunohistochemistry; Kainic Acid; Kinetics; Microscopy, Electron; Microscopy, Fluorescence; Models, Neurological; N-Methylaspartate; Neuroglia; Neurons; Quisqualic Acid; Rats; Serotonin; Suprachiasmatic Nucleus; Synapses; Time Factors | 1992 |
Competitive antagonism of glutamate receptor channels by substituted benzazepines in cultured cortical neurons.
Topics: Animals; Benzazepines; Binding Sites; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1992 |
Repetitive injections of L-glutamic acid, in contrast to those of N-methyl-D,L-aspartic acid, fail to elicit sustained hypothalamic GnRH release in the prepubertal male rhesus monkey (Macaca mulatta).
Topics: Animals; Biological Assay; Glutamates; Glutamic Acid; Gonadotropin-Releasing Hormone; Hypothalamus; Injections, Intravenous; Kainic Acid; Macaca mulatta; Male; N-Methylaspartate; Sexual Maturation; Time Factors | 1992 |
Estradiol selectively regulates agonist binding sites on the N-methyl-D-aspartate receptor complex in the CA1 region of the hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding Sites; Binding, Competitive; Estradiol; Female; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Ovariectomy; Progesterone; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Selective effects of cyanide (100 microM) on the excitatory amino acid-induced elevation of intracellular calcium levels in neuronal culture.
Topics: Amino Acids; Animals; Calcium; Cells, Cultured; Cerebellum; Diltiazem; Glutamates; Glutamic Acid; Kainic Acid; Lanthanum; Membrane Potentials; N-Methylaspartate; Neurons; Potassium Chloride; Quisqualic Acid; Rats; Rats, Inbred Strains; Sodium Cyanide | 1992 |
Regulation of nerve growth factor and nerve growth factor receptor production by NMDA in C6 glioma cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Base Sequence; Blotting, Northern; Bucladesine; Cyclic AMP; Glioma; Kainic Acid; Molecular Sequence Data; N-Methylaspartate; Neoplasm Proteins; Nerve Growth Factors; Quisqualic Acid; Rats; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Nerve Growth Factor; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 1992 |
Insulin-specific sensitization of cultured cerebrocortical neurons to glutamate excitotoxicity.
Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Fibroblast Growth Factor 2; Glutamates; Glutamic Acid; Insulin; Insulin-Like Growth Factor I; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Rats | 1992 |
The effect of hypoxia on neurotransmitter phenotype of forebrain cholinergic neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Cell Hypoxia; Cells, Cultured; Choline O-Acetyltransferase; Embryo, Mammalian; Glutamates; Glutamic Acid; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Growth Factors; Neurons; Phenotype; Prosencephalon; Quinoxalines; Rats; Rats, Inbred Strains | 1992 |
N-methyl-D-aspartate exposure blocks glutamate toxicity in cultured cerebellar granule cells.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Culture Media; Cytoplasmic Granules; Excitatory Amino Acid Antagonists; Glucose; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Ouabain; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sensitivity and Specificity; Tritium | 1992 |
Dual-component miniature excitatory synaptic currents in rat hippocampal CA3 pyramidal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Evoked Potentials, Somatosensory; Hippocampus; Hypertonic Solutions; In Vitro Techniques; Kainic Acid; Kinetics; Membrane Potentials; Microelectrodes; N-Methylaspartate; Neurons; Potassium; Pyramidal Tracts; Quinoxalines; Rats; Rats, Inbred Strains; Synapses; Tetrodotoxin | 1992 |
Inhibitory effect of CCK-8 and ceruletide on glutamate-induced rises in intracellular free calcium concentrations in rat neuron cultures.
Topics: Animals; Calcium; Cells, Cultured; Ceruletide; Cholecystokinin; Cytarabine; Female; Fura-2; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Pregnancy; Rats; Rats, Wistar; Receptors, Cholecystokinin | 1992 |
Cortical AMPA receptors: age-dependent regulation by cellular depolarization and agonist stimulation.
Topics: Aging; Animals; Cerebral Cortex; Glutamates; Glutamic Acid; Kainic Acid; Male; Membrane Potentials; Muscimol; N-Methylaspartate; Neuronal Plasticity; Quisqualic Acid; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, AMPA; Receptors, Neurotransmitter; Veratridine | 1992 |
The neuroprotective properties of ifenprodil, a novel NMDA receptor antagonist, in neuronal cell culture toxicity studies.
Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cyanates; Dizocilpine Maleate; Glutamates; Glutamic Acid; Kainic Acid; Mice; N-Methylaspartate; Neurons; Piperidines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate | 1992 |
Cyanide selectively augments kainate- but not NMDA-induced release of glutamate and taurine.
Topics: Animals; Cells, Cultured; Cerebellum; Cyanides; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Taurine | 1992 |
N-acetylaspartylglutamate acts as an agonist upon homomeric NMDA receptor (NMDAR1) expressed in Xenopus oocytes.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cloning, Molecular; Dipeptides; Dose-Response Relationship, Drug; Female; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Membrane Potentials; N-Methylaspartate; Oocytes; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transcription, Genetic; Xenopus laevis | 1992 |
Excitatory effect of N-methyl-D-aspartate and kainate receptor on the 2-deoxyglucose uptake in the rat suprachiasmatic nucleus in vitro.
Topics: Animals; Deoxyglucose; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Motor Activity; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Suprachiasmatic Nucleus | 1992 |
Stimulation of cultured cerebellar granule cells via glutamate receptors induces TRE- and CRE-binding activities mediated by common DNA-binding complexes.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Base Sequence; Blotting, Northern; Calcium; Cells, Cultured; Cerebellum; Cyclic AMP; DNA-Binding Proteins; Kainic Acid; Magnesium; Mice; Mice, Inbred ICR; Molecular Sequence Data; N-Methylaspartate; Protein Binding; Proto-Oncogene Proteins c-fos; Quinoxalines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Tetradecanoylphorbol Acetate | 1992 |
Characterization and regulation of a high affinity [3H]CNQX labelled AMPA receptor in rat neocortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cerebral Cortex; In Vitro Techniques; Kainic Acid; Male; Muscimol; N-Methylaspartate; Oxadiazoles; Quinoxalines; Quisqualic Acid; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Neurotransmitter; Tritium | 1992 |
Intrathecal administration of non-NMDA receptor agonists increases arterial pressure and heart rate in the rat.
Topics: Animals; Blood Pressure; Carbachol; Ganglia, Autonomic; Ganglionic Blockers; Glutamates; Glutamic Acid; Heart Rate; Hexamethonium; Hexamethonium Compounds; Injections, Spinal; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptic Transmission | 1992 |
Excitatory neurotransmitters in the lateral habenula and pedunculopontine nucleus of rat modulate limbic seizures induced by pilocarpine.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Behavior, Animal; Electroencephalography; Epilepsy; Glutamine; Kainic Acid; Limbic System; Male; N-Methylaspartate; Neurotransmitter Agents; Pilocarpine; Pons; Rats; Rats, Wistar; Thalamus | 1992 |
Differential effects of neuroexcitatory amino acids on corticotropin-releasing hormone-41 and vasopressin release from rat hypothalamic explants.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arginine Vasopressin; Corticotropin-Releasing Hormone; Glycine; Hypothalamus; Kainic Acid; Magnesium; Male; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar | 1992 |
Effect of magnesium on calcium influx activated by glutamate and its agonists in cultured cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Calcium Radioisotopes; Cells, Cultured; Cerebellum; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Nifedipine; Phencyclidine; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Verapamil | 1992 |
A highly potent and selective N-methyl-D-aspartate receptor antagonist from the venom of the Agelenopsis aperta spider.
Topics: Agatoxins; Animals; Aspartic Acid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neurotoxins; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spiders | 1992 |
NMDA-, but not kainate- or quisqualate-dependent increases in cerebellar cGMP are dependent upon monoaminergic innervation.
Topics: Animals; Cerebellum; Cyclic GMP; Kainic Acid; Male; Mice; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Quisqualic Acid; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Serine | 1992 |
Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat.
Topics: Action Potentials; Animals; Animals, Newborn; Aspartic Acid; Brain Stem; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Kainic Acid; Locomotion; N-Methylaspartate; Nerve Net; Quisqualic Acid; Rats; Rats, Wistar; Serotonin; Spinal Cord | 1992 |
Glutamate receptor agonists stimulate nitric oxide synthase in primary cultures of cerebellar granule cells.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Calcium; Cells, Cultured; Cerebellum; Citrulline; Cyclic GMP; Glutamates; Glutamic Acid; Granulocytes; Kainic Acid; N-Methylaspartate; Nitric Oxide Synthase; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1992 |
N-methyl-D-aspartic acid (NMDA) and non-NMDA receptors regulating hippocampal norepinephrine release. I. Location on axon terminals and pharmacological characterization.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Axons; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptosomes | 1992 |
Quinoxaline derivatives: structure-activity relationships and physiological implications of inhibition of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor-mediated currents and synaptic potentials.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebral Cortex; Electrophysiology; Evoked Potentials; Female; Glycine; Hippocampus; Ibotenic Acid; Kainic Acid; Male; Membrane Potentials; N-Methylaspartate; Oocytes; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Structure-Activity Relationship; Synapses; Xenopus | 1992 |
Possible role of cGMP in excitatory amino acid induced cytotoxicity in cultured cerebral cortical neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cholera Toxin; Cyclic GMP; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Mice; N-Methylaspartate; Neurons; Pertussis Toxin; Quisqualic Acid; Time Factors; Virulence Factors, Bordetella | 1992 |
Excitatory amino acid receptors on isolated retinal ganglion cells from the goldfish.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cells, Cultured; Chlorides; Electrophysiology; Glutamates; Glutamic Acid; Goldfish; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Retinal Ganglion Cells; Sodium | 1992 |
Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainate in cultured cerebral cortical neu
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Dantrolene; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Mice; N-Methylaspartate; Neurotoxins; Quisqualic Acid; Verapamil | 1992 |
Arcaine blocks N-methyl-D-aspartate receptor responses by an open channel mechanism: whole-cell and single-channel recording studies in cultured hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biguanides; Cations, Divalent; Cells, Cultured; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glycine; Hippocampus; Ibotenic Acid; Ion Channels; Kainic Acid; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Antinociceptive effects of intrathecal taurine and calcium in the mouse.
Topics: Amino Acids; Animals; Behavior, Animal; Calcium; Drug Interactions; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Naloxone; Nociceptors; Pain Measurement; Substance P; Taurine | 1992 |
Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex.
Topics: Alkylating Agents; Animals; Calcium; Electrophysiology; Intracellular Membranes; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Nitric Oxide; Nitroso Compounds; Oxidation-Reduction; Potassium; Receptors, N-Methyl-D-Aspartate | 1992 |
Purification of AMPA type glutamate receptor by a spider toxin.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cattle; Cerebellum; Chloride Channels; Chromatography, Affinity; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Glutamates; Glutamic Acid; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Kinetics; Liposomes; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Quisqualic Acid; Receptors, AMPA; Receptors, Neurotransmitter; Spider Venoms | 1992 |
NMDA treatment and K(+)-induced depolarization selectively promote the expression of an NMDA-preferring class of the ionotropic glutamate receptors in cerebellar granule neurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cell Survival; Cells, Cultured; Cerebellar Cortex; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Potassium; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Up-Regulation | 1992 |
Failure of a protein synthesis inhibitor to modify glutamate receptor-mediated neurotoxicity in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anisomycin; Cell Death; Glutamate Decarboxylase; Glutamates; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Neurons; Protein Biosynthesis; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1992 |
Neuronal loss or replacement in the injured adult cerebral neocortex induces extensive remodeling of intrinsic and afferent neural systems.
Topics: Afferent Pathways; Analysis of Variance; Animals; Axonal Transport; Cerebral Cortex; Choline O-Acetyltransferase; Female; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Nerve Regeneration; Neurons; Neurotoxins; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Sympathectomy | 1992 |
Comparison of ethanol sensitivity of rat brain kainate, DL-alpha-amino-3-hydroxy-5-methyl-4-isoxalone proprionic acid and N-methyl-D-aspartate receptors expressed in Xenopus oocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Calcium; Ethanol; Female; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Oocytes; Rats; Rats, Inbred Strains; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Xenopus laevis | 1992 |
Stimulation of noradrenaline release in human cerebral cortex mediated by N-methyl-D-aspartate (NMDA) and non-NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Glycine; Humans; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Tritium | 1992 |
Domoic acid toxicity in rats and mice after intracerebroventricular administration: comparison with excitatory amino acid agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Ibotenic Acid; Injections, Intraventricular; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurotoxins; Rats; Rats, Inbred Strains | 1992 |
Evoked endogenous taurine release from cultured cerebellar neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Piperazines; Quinoxalines; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Taurine | 1992 |
Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cycloleucine; Drug Synergism; Glutamates; Glutamic Acid; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Myocardial Contraction; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Synapses; Synaptic Transmission | 1992 |
Pharmacological characterization of non-NMDA subtypes of glutamate receptor in the neonatal rat hemisected spinal cord in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Methohexital; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1992 |
Induction of cobalt accumulation by excitatory amino acids within neurons of the hippocampal slice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport; Cobalt; Gerbillinae; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kinetics; Male; N-Methylaspartate; Neurons | 1992 |
NMDA-induced release of nitric oxide potentiates aspartate overflow from cerebellar slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arginine; Aspartic Acid; Cerebellum; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Magnesium; N-Methylaspartate; Nitric Oxide; omega-N-Methylarginine; Quisqualic Acid; Rats; Rats, Wistar | 1992 |
Uncompetitive antagonist binding: a biochemical index of activation of the NMDA receptor-coupled ion channel.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Culture Techniques; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1992 |
Effects of L- and N-type Ca2+ channel antagonists on excitatory amino acid-evoked dopamine release.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Cells, Cultured; Dopamine; Kainic Acid; Mesencephalon; N-Methylaspartate; Nitrendipine; omega-Conotoxin GVIA; Peptides, Cyclic; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Veratridine | 1992 |
Polyamine spider toxins are potent un-competitive antagonists of rat cortex excitatory amino acid receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Ibotenic Acid; In Vitro Techniques; Indoleacetic Acids; Kainic Acid; Male; N-Methylaspartate; Polyamines; Rats; Receptors, Neurotransmitter; Spider Venoms; Xenopus laevis | 1992 |
Amitriptyline, desipramine, cyproheptadine and carbamazepine, in concentrations used therapeutically, reduce kainate- and N-methyl-D-aspartate-induced intracellular Ca2+ levels in neuronal culture.
Topics: Amitriptyline; Animals; Calcium; Calcium Channel Blockers; Carbamazepine; Cells, Cultured; Cerebellum; Cyproheptadine; Desipramine; Kainic Acid; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate | 1992 |
Apamin blocks the slow AHP in lamprey and delays termination of locomotor bursts.
Topics: Action Potentials; Animals; Apamin; In Vitro Techniques; Kainic Acid; Lampreys; Locomotion; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Potassium Channels; Spinal Cord | 1992 |
Treatment with excitatory amino acids or high K+ and NMDA receptors in cerebellar granule cells.
Topics: Amino Acids; Animals; Calcium; Calcium Radioisotopes; Cells, Cultured; Cerebellum; Kainic Acid; N-Methylaspartate; Neurons; Potassium; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1992 |
Alcohol withdrawal reaction as a result of adaptive changes of excitatory amino acid receptors.
Topics: Animals; Brain; Dizocilpine Maleate; Electrophysiology; Ethanol; Injections, Intraperitoneal; Kainic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Substance Withdrawal Syndrome | 1992 |
Computer simulation of the segmental neural network generating locomotion in lamprey by using populations of network interneurons.
Topics: Animals; Computer Simulation; Evoked Potentials; gamma-Aminobutyric Acid; Interneurons; Kainic Acid; Lampreys; Models, Neurological; Motor Activity; N-Methylaspartate; Nerve Net; Receptors, N-Methyl-D-Aspartate; Synapses | 1992 |
The release of dopamine from nerve terminals and dendrites of nigrostriatal neurons induced by excitatory amino acids in the conscious rat.
Topics: Amino Acids; Animals; Corpus Striatum; Dendrites; Dopamine; Kainic Acid; Male; N-Methylaspartate; Nerve Endings; Rats; Rats, Inbred Strains; Substantia Nigra | 1992 |
In vivo electrophysiological evidence for a selective modulation of N-methyl-D-aspartate-induced neuronal activation in rat CA3 dorsal hippocampus by sigma ligands.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Electrophysiology; Hippocampus; Kainic Acid; Ligands; Male; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Comparative analysis of seizures induced by intracerebroventricular administration of NMDA, kainate and quisqualate in mice.
Topics: Animals; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Injections, Intraventricular; Kainic Acid; Male; Mice; Myoclonus; N-Methylaspartate; Quisqualic Acid; Seizures; Status Epilepticus | 1992 |
Amitriptyline prevents N-methyl-D-aspartate (NMDA)-induced toxicity, does not prevent NMDA-induced elevations of extracellular glutamate, but augments kainate-induced elevations of glutamate.
Topics: Amitriptyline; Animals; Cell Death; Cells, Cultured; Extracellular Matrix; Glutamates; Imipramine; Kainic Acid; Lethal Dose 50; N-Methylaspartate; Neurons; Nortriptyline; Quisqualic Acid; Rats; Rats, Inbred Strains; Taurine | 1992 |
Quantitative autoradiographic analysis of excitatory amino acid receptors in the cat spinal cord.
Topics: Animals; Aspartic Acid; Autoradiography; Cats; Kainic Acid; N-Methylaspartate; Receptors, Amino Acid; Receptors, Cell Surface; Sodium; Spinal Cord | 1991 |
The effects of N-methyl-D-aspartate and kainate lesions of the rat striatum on striatal ornithine decarboxylase activity and polyamine levels.
Topics: Animals; Biogenic Polyamines; Corpus Striatum; Injections; Isoquinolines; Kainic Acid; Macrophages; Male; N-Methylaspartate; Nerve Tissue Proteins; Neuroglia; Ornithine Decarboxylase; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stereotaxic Techniques | 1991 |
Behavioural effects of NMDA injected into the hypothalamic paraventricular nucleus of the rat.
Topics: Animals; Electric Stimulation; Glutamates; Grooming; Kainic Acid; Male; Microinjections; N-Methylaspartate; Paraventricular Hypothalamic Nucleus; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Reference Values; Stereotaxic Techniques; Time Factors | 1991 |
Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases.
Topics: Animals; Cells, Cultured; Cyclic AMP; Ethers, Cyclic; Fetus; Hippocampus; Homeostasis; Kainic Acid; Kinetics; Macromolecular Substances; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Okadaic Acid; Phosphoprotein Phosphatases; Protein Kinase Inhibitors; Protein Kinases; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1991 |
Progesterone administration attenuates excitatory amino acid responses of cerebellar Purkinje cells.
Topics: Amino Acids; Animals; Bicuculline; Cerebellum; Drug Synergism; Electrophysiology; Female; Kainic Acid; N-Methylaspartate; Progesterone; Purkinje Cells; Quisqualic Acid; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 1991 |
Autoradiographic localisations of glutamatergic ligand binding sites in Xenopus brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding Sites; Brain Chemistry; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Xenopus | 1991 |
Arylamine toxins from funnel-web spider (Agelenopsis aperta) venom antagonize N-methyl-D-aspartate receptor function in mammalian brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Calcium; Cells, Cultured; Cerebellum; Cytosol; Evoked Potentials; Glycine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Spider Venoms; Structure-Activity Relationship; Synapses; Synaptic Transmission | 1991 |
Excitatory amino acids: new tools for old stories or pharmacological subtypes of glutamate receptors: electrophysiological studies.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Brain Stem; Cerebral Cortex; Electrophysiology; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Polyamines; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Wasp Venoms | 1991 |
Differences in the luteinizing hormone and prolactin responses to multiple injections of kainate, as compared to N-methyl-D,L-aspartate, in cycling rats.
Topics: Animals; Diestrus; Estrus; Female; Gonadotropin-Releasing Hormone; Kainic Acid; Luteinizing Hormone; N-Methylaspartate; Prolactin; Rats; Rats, Inbred Strains; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
The relative potency of pentobarbital in suppressing the kainic acid- or the N-methyl-D-aspartic acid-induced enhancement of cGMP in cerebellar cells.
Topics: Animals; Cells, Cultured; Cerebellum; Cyclic GMP; Kainic Acid; N-Methylaspartate; Neurons; Pentobarbital; Rats; Rats, Inbred Strains | 1991 |
Activation of AMPA/kainic acid glutamate receptors in the zona incerta stimulates locomotor activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Diencephalon; Ibotenic Acid; Injections; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Receptors, Neurotransmitter; Substantia Nigra | 1991 |
Excitatory amino acid binding sites in the caudate nucleus and frontal cortex of Huntington's disease.
Topics: Adolescent; Adult; Age Factors; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Binding, Competitive; Caudate Nucleus; Cell Death; Child; Dizocilpine Maleate; Frontal Lobe; Glycine; Humans; Huntington Disease; Ibotenic Acid; Kainic Acid; Middle Aged; N-Methylaspartate; Phencyclidine; Receptors, AMPA; Receptors, Glutamate; Receptors, Glycine; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1991 |
A metabotropic glutamate receptor agonist does not mediate neuronal degeneration in cortical culture.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebral Cortex; Cycloleucine; Embryo, Mammalian; Glutamates; Ibotenic Acid; Kainic Acid; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Receptors, Glutamate; Receptors, Neurotransmitter; Tetrodotoxin | 1991 |
Effects of two volatile anesthetics and a volatile convulsant on the excitatory and inhibitory amino acid responses in dissociated CNS neurons of the rat.
Topics: Amino Acids; Animals; Brain Stem; Dose-Response Relationship, Drug; Electrophysiology; Enflurane; Flurothyl; gamma-Aminobutyric Acid; Glutamates; Glycine; Halothane; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Neurotransmitter | 1991 |
Lanthanum actions on excitatory amino acid-gated currents and voltage-gated calcium currents in rat dorsal horn neurons.
Topics: Animals; Calcium Channels; Cells, Cultured; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Ion Channel Gating; Kainic Acid; Lanthanum; Membrane Potentials; N-Methylaspartate; Quisqualic Acid; Rats; Spinal Cord; Zinc | 1991 |
Transient postnatal increases in excitatory amino acid binding sites in rat ventral mesencephalon.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Membrane; Corpus Striatum; Glutamates; Ibotenic Acid; Kainic Acid; Mesencephalon; N-Methylaspartate; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
Acetylcholine release from the rabbit retina mediated by kainate receptors.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Choline; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Rabbits; Receptors, Kainic Acid; Receptors, Neurotransmitter; Retina | 1991 |
Neurochemical characterization of excitotoxin lesions in the cerebral cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Homocysteine; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; NADPH Dehydrogenase; Neuropeptides; Neurotoxins; Neurotransmitter Agents; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1991 |
GABAA and excitatory amino acid receptors in dorsomedial hypothalamus and heart rate in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Blood Pressure; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Heart Rate; Hypothalamus; Kainic Acid; Male; Microinjections; N-Methylaspartate; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1991 |
N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Cells, Cultured; Electrophysiology; Kainic Acid; N-Methylaspartate; Quinoxalines; Rats; Retinal Ganglion Cells | 1991 |
L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes.
Topics: 2-Amino-5-phosphonovalerate; Alzheimer Disease; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glycine; Kainic Acid; N-Methylaspartate; Phosphoserine; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1991 |
Met-enkephalin release from slices of the rat striatum and globus pallidus: stimulation by excitatory amino acids.
Topics: Amino Acids; Animals; Corpus Striatum; Enkephalin, Methionine; Globus Pallidus; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Potassium; Quisqualic Acid; Radioimmunoassay; Rats; Rats, Inbred Strains; Stimulation, Chemical | 1991 |
Effects of excitatory amino acids and their antagonists on the light response of luminosity and color-opponent horizontal cells in the turtle (Pseudemys scripta elegans) retina.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Color Perception; Dizocilpine Maleate; Electrophysiology; Kainic Acid; Light; N-Methylaspartate; Photic Stimulation; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Turtles | 1991 |
Excitatory amino acid response in isolated spiral ganglion cells of guinea pig cochlea.
Topics: Amino Acids; Animals; Chickens; Cochlea; Electrophysiology; Excitatory Amino Acid Antagonists; Female; Ganglia; Glutamates; Guinea Pigs; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurons, Afferent; Neurotransmitter Agents; Quisqualic Acid; Species Specificity | 1991 |
Differential distribution of excitatory amino acid receptors on embryonic rat spinal cord neurons in culture.
Topics: Animals; Axons; Calcium Channels; Cells, Cultured; Electrophysiology; Embryo, Mammalian; Ion Channel Gating; Kainic Acid; N-Methylaspartate; Neurons; Neurotransmitter Agents; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord; Tissue Distribution | 1991 |
Autoradiographic characterization of [3H]L-glutamate binding sites in developing mouse cerebellar cortex.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Binding, Competitive; Calcium; Cerebellar Cortex; Chlorides; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Mice; N-Methylaspartate; Protein Binding; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses | 1991 |
Regulation of CCK release in cerebral cortex by N-methyl-D-aspartate receptors: sensitivity to APV, MK-801, kynurenate, magnesium and zinc ions.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Dizocilpine Maleate; Kainic Acid; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Potassium; Quisqualic Acid; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Sincalide; Zinc | 1991 |
A comparison of excitotoxic lesions of the basal forebrain by kainate, quinolinate, ibotenate, N-methyl-D-aspartate or quisqualate, and the effects on toxicity of 2-amino-5-phosphonovaleric acid and kynurenic acid in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Diseases; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats | 1991 |
NMDA receptors in the intermediolateral column of the spinal cord mediate sympathoexcitatory cardiac responses elicited from the ventrolateral medullary pressor area.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Convulsants; Glutamates; Glutamic Acid; Heart Rate; Ibotenic Acid; Kainic Acid; Male; Medulla Oblongata; Microinjections; Myocardial Contraction; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1991 |
Activation of excitatory amino acid receptors cannot alone account for anoxia-induced impairment of protein synthesis in rat hippocampal slices.
Topics: Animals; Aspartic Acid; Carbon Radioisotopes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; Hypoxia; Kainic Acid; Lysine; Male; N-Methylaspartate; Nerve Tissue Proteins; Phenazocine; Phencyclidine; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate | 1991 |
Selective blockade of non-NMDA receptors does not block rapidly triggered glutamate-induced neuronal death.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cell Line; Cell Survival; Cerebral Cortex; Fetus; Glutamates; Glutamic Acid; Glycine; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
Presynaptic modulation of glutamate and dynorphin release by excitatory amino acids in the guinea-pig hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Dynorphins; Glutamates; Guinea Pigs; Hippocampus; Ibotenic Acid; Kainic Acid; Kinetics; Male; N-Methylaspartate; Potassium; Quinoxalines; Quisqualic Acid; Synapses; Synaptosomes | 1991 |
Excitatory synaptic potentials in kainic acid-denervated rat CA1 pyramidal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Denervation; Evoked Potentials; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synapses | 1991 |
Pontomedullary glutamate receptors mediating locomotion and muscle tone suppression.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cats; Electric Stimulation; Female; Kainic Acid; Kinetics; Locus Coeruleus; Male; Medulla Oblongata; Motor Activity; Muscles; N-Methylaspartate; Pons; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1991 |
Dipeptides--analogues of N-acetylaspartylglutamate inhibit convulsive effects of excitatory amino acids in mice.
Topics: Animals; Cerebral Ventricles; Dipeptides; Glutamates; Glutamic Acid; Injections, Intraventricular; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurotoxins; Pentylenetetrazole; Seizures; Structure-Activity Relationship | 1991 |
Characterization of L-[3H]glutamate binding sites in bovine brain coated vesicles.
Topics: Animals; Binding Sites; Brain; Cattle; Cell Membrane; Chromatography, Gel; Clathrin; Endosomes; Glutamates; GTP-Binding Proteins; Guanosine Triphosphate; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Radioimmunoassay; Receptors, Glutamate; Receptors, Neurotransmitter | 1991 |
Uneven distribution of excitatory amino acid receptors on ventral horn neurones of newborn rat spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Aspartic Acid; Dendrites; Dose-Response Relationship, Drug; Glutamates; Kainic Acid; Membrane Potentials; N-Methylaspartate; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord | 1991 |
Evoked field potential changes in the rat hippocampus produced by toxic doses of glutamate agonists and metabolic inhibitors: correlation with subsequent neuronal death.
Topics: Animals; Cell Death; Electric Stimulation; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Iodoacetates; Iodoacetic Acid; Kainic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1991 |
Interactions of glutamate receptor agonists coupled to changes in intracellular Ca2+ in rat cerebellar granule cells in primary culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Fura-2; Glutamates; Kainic Acid; Kinetics; Magnesium; N-Methylaspartate; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Sodium; Spectrometry, Fluorescence | 1991 |
Kainate and NMDA toxicity for cultured developing and adult rat spiral ganglion neurons: further evidence for a glutamatergic excitatory neurotransmission at the inner hair cell synapse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Cell Survival; Cells, Cultured; Cochlea; Ganglia; Glutamates; Glutamic Acid; Hair Cells, Auditory, Inner; Immunohistochemistry; In Vitro Techniques; Indicators and Reagents; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Neurons, Afferent; Organ of Corti; Quisqualic Acid; Rats; Rats, Inbred Strains; Synaptic Transmission | 1991 |
Excitatory amino acid receptors mediate synaptic responses to visual stimuli in superior colliculus neurones of the rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ibotenic Acid; Iontophoresis; Kainic Acid; N-Methylaspartate; Neurons; Photic Stimulation; Piperazines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Superior Colliculi; Synapses | 1991 |
Prolonged exposure to N-methyl-D-aspartate increases intracellular and secreted somatostatin in rat cortical cells.
Topics: Animals; Cerebral Cortex; Female; Kainic Acid; N-Methylaspartate; Pregnancy; Quisqualic Acid; Rats; Somatostatin | 1991 |
The inhibition of glutamine synthetase in rat corpus striatum in vitro by methionine sulfoximine increases the neurotoxic effects of kainate and N-methyl-D-aspartate.
Topics: Animals; Cerebellum; Corpus Striatum; Drug Synergism; Female; Glutamate-Ammonia Ligase; Kainic Acid; Methionine Sulfoximine; N-Methylaspartate; Nerve Degeneration; Nervous System Diseases; Neuroglia; Phosphopyruvate Hydratase; Rats; Rats, Inbred Strains | 1991 |
Excitatory synapse in the rat hippocampus in tissue culture and effects of aniracetam.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Embryo, Mammalian; Evoked Potentials; Hippocampus; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Pyramidal Tracts; Pyrrolidinones; Quinoxalines; Quisqualic Acid; Rats; Synapses | 1991 |
Receptor sub-types involved in responses of Purkinje cell to exogenous excitatory amino acids and local electrical stimulation in cerebellar slices in the rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Amino Acids; Animals; Aspartic Acid; Bicuculline; Cerebellum; Electric Stimulation; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Purkinje Cells; Quinoxalines; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1991 |
Excitatory amino acids evoke taurine release from cerebral cortex slices from adult and developing mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dipeptides; Female; Glutamates; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Neurotoxins; Potassium; Quisqualic Acid; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Secretory Rate; Stimulation, Chemical; Taurine | 1991 |
NMDA and non-NMDA receptors mediate visual responses of neurons in the cat's lateral geniculate nucleus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cats; Electric Stimulation; Evoked Potentials; Geniculate Bodies; Kainic Acid; N-Methylaspartate; Neurons; Piperazines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission; Time Factors; Visual Perception | 1991 |
Excitotoxicity in the embryonic chick spinal cord.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; beta-Alanine; Chick Embryo; Cyanobacteria Toxins; Dizocilpine Maleate; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Quinoxalines; Quisqualic Acid; Spinal Cord | 1991 |
Central neural mediators of secondary hyperalgesia following heat injury in rats: neuropeptides and excitatory amino acids.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Capsaicin; Functional Laterality; Hot Temperature; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neuronal Plasticity; Neuropeptides; Pain; Quinoxalines; Rats; Reflex; Time Factors | 1991 |
CNQX, a new non-NMDA receptor antagonist, reduces spike wave discharges in the WAG/Rij rat model of absence epilepsy.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Azasteroids; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Absence; Female; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Postural Balance; Pregnanediones; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Ammonia-induced alterations in glutamate and muscimol binding to cerebellar synaptic membranes.
Topics: Ammonia; Animals; Cerebellum; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Muscimol; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Glutamate; Receptors, Neurotransmitter; Synaptic Membranes | 1991 |
Intercellular action of nitric oxide in adult rat cerebellar slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebellum; Cyclic GMP; Drug Interactions; Glutamates; Glutamic Acid; Hemoglobins; Hydroxylamine; Hydroxylamines; Ibotenic Acid; Kainic Acid; Molsidomine; N-Methylaspartate; Nitric Oxide; Nitroprusside; Penicillamine; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; S-Nitroso-N-Acetylpenicillamine | 1991 |
Vinpocetine preferentially antagonizes quisqualate/AMPA receptor responses: evidence from release and ligand binding studies.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cerebral Cortex; Corpus Striatum; Dopamine; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Male; Membranes; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, AMPA; Receptors, Cell Surface; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tritium; Vinca Alkaloids | 1991 |
Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead.
Topics: Animals; Aspartic Acid; Calcium; Dibenzocycloheptenes; Dizocilpine Maleate; Electric Conductivity; Glycine; Hippocampus; Ion Channels; Kainic Acid; Lead; Learning Disabilities; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Voltage-gated and chemically gated ionic channels in the cultured cochlear ganglion neurone of the chick.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium Channels; Cell Membrane Permeability; Chick Embryo; Cochlear Nerve; Ganglia; Glutamates; In Vitro Techniques; Ion Channel Gating; Ion Channels; Kainic Acid; Kinetics; Membrane Potentials; N-Methylaspartate; Potassium Channels; Sodium Channels | 1990 |
Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding Sites; Cerebellum; Electric Conductivity; Glycine; Hydrogen-Ion Concentration; Ibotenic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Protons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Spermine and philanthotoxin potentiate excitatory amino acid responses of Xenopus oocytes injected with rat and chick brain RNA.
Topics: Amino Acids; Animals; Aspartic Acid; Bee Venoms; Brain; Chickens; Kainic Acid; Male; Membrane Potentials; Microinjections; N-Methylaspartate; Neurotoxins; Oocytes; Oxadiazoles; Poly A; Polyamines; Quisqualic Acid; Rats; Rats, Inbred Strains; RNA; RNA, Messenger; Spermine; Wasp Venoms; Xenopus | 1990 |
Modulation of the N-methyl-D-aspartate channel by extracellular H+.
Topics: Animals; Aspartic Acid; Cells, Cultured; Embryo, Mammalian; gamma-Aminobutyric Acid; Glycine; Hippocampus; Hydrogen-Ion Concentration; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Neurotoxins; Oxadiazoles; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Effects of urethane and ketamine on substance P- and excitatory amino acid-induced behavior in mice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Behavior, Animal; Injections, Spinal; Isomerism; Kainic Acid; Ketamine; Male; Mice; N-Methylaspartate; Quisqualic Acid; Substance P; Urethane | 1990 |
Glutamate, kainate and quisqualate enhance GABA-dependent chloride uptake in cortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biological Transport; Cerebral Cortex; Chloride Channels; Chlorides; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Inbred Strains; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Receptors, GABA-A | 1990 |
Glutamate-induced inward current in a clonal neuroblastoma cell line.
Topics: Animals; Electrophysiology; Glutamates; Humans; Ion Channels; Kainic Acid; Mice; N-Methylaspartate; Neuroblastoma; Quisqualic Acid; Rats; Tumor Cells, Cultured | 1990 |
Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord.
Topics: Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Drug Interactions; Glutamates; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Pain; Pain Measurement; Quisqualic Acid; Rats; Rats, Inbred Strains; Reaction Time; Self Mutilation; Spinal Cord; Substance P; Taurine | 1990 |
Glutamate-induced increases in intracellular Ca2+ in cultured frog tectal cells mediated by direct activation of NMDA receptor channels.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cells, Cultured; Dizocilpine Maleate; Electrophysiology; Glutamates; Glutamic Acid; Intracellular Membranes; Ion Channels; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Rana pipiens; Receptors, N-Methyl-D-Aspartate; Superior Colliculi | 1991 |
Substance P modulates glutamate-induced currents in acutely isolated rat spinal dorsal horn neurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Evoked Potentials; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Substance P | 1990 |
Glutamate: three meetings but how many receptors? Excitatory Amino Acids 1990: a Fidia Research Foundation Symposium, Padua, Italy, May 21-26, 1990. Excitatory Amino Acid Receptors in the Brain: Functions and Disorders, Montreal, Canada, June 23-24, 1990.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Glutamates; Glutamic Acid; GTP-Binding Proteins; Ibotenic Acid; Ion Channel Gating; Ion Channels; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Quisqualic Acid; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Signal Transduction | 1990 |
The effect of external pH changes on responses to excitatory amino acids in mouse hippocampal neurones.
Topics: Action Potentials; Amino Acids; Animals; Cells, Cultured; Glutamates; Hippocampus; Hydrogen-Ion Concentration; Ion Channels; Kainic Acid; Magnesium; Mice; Mice, Inbred BALB C; N-Methylaspartate; Neurons; Quisqualic Acid; Zinc | 1990 |
Reduced NMDA receptor-ion channel function in the vitamin B-6 restricted neonatal rat brain.
Topics: Animals; Animals, Newborn; Brain Chemistry; Cerebral Cortex; Dizocilpine Maleate; Female; Hippocampus; In Vitro Techniques; Ion Channels; Kainic Acid; Kinetics; N-Methylaspartate; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Vitamin B 6 Deficiency | 1991 |
Block of kainate receptor channels by Ca2+ in isolated spinal trigeminal neurons of rat.
Topics: Acetylcholine; Animals; Calcium; Cell Separation; Dose-Response Relationship, Drug; Electrophysiology; Ion Channels; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Rats; Receptors, Kainic Acid; Receptors, Neurotransmitter; Trigeminal Nerve | 1991 |
Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Naloxone; Nociceptors; Pain; Peptide Fragments; Reaction Time; Substance P; Urethane | 1991 |
Currents through single glutamate receptor channels in outside-out patches from rat cerebellar granule cells.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Glutamates; Ion Channel Gating; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Time Factors | 1991 |
Enhancement of the glutamate response by cAMP-dependent protein kinase in hippocampal neurons.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Cells, Cultured; Colforsin; Electric Conductivity; Glutamates; Hippocampus; Ion Channel Gating; Ion Channels; Kainic Acid; Kinetics; Membrane Potentials; N-Methylaspartate; Neurons; Protein Kinases; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1991 |
Multiple effects of tetraethylammonium on N-methyl-D-aspartate receptor-channels in mouse brain neurons in cell culture.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Glycine; Ion Channel Gating; Ion Channels; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Quisqualic Acid; Receptors, Cell Surface; Tetraethylammonium; Tetraethylammonium Compounds | 1991 |
Agonist-activated cobalt uptake identifies divalent cation-permeable kainate receptors on neurons and glial cells.
Topics: Animals; Biological Transport; Calcium; Cells, Cultured; Cerebellum; Cobalt; Glutamates; Hippocampus; In Vitro Techniques; Ion Channel Gating; Ion Channels; Kainic Acid; Manganese; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1991 |
Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures.
Topics: Animals; Culture Techniques; Dose-Response Relationship, Drug; Fluorescence; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Osmolar Concentration; Propidium; Staining and Labeling | 1991 |
Behavioral sensitization to kainic acid and quisqualic acid in mice: comparison to NMDA and substance P responses.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Behavior, Animal; Capsaicin; Concanavalin A; Drug Tolerance; GABA Antagonists; Glycine; Injections, Spinal; Kainic Acid; Mice; N-Methylaspartate; Quisqualic Acid; Spinal Cord; Substance P | 1991 |
Absence of implication of L-arginine/nitric oxide pathway on neuronal cell injury induced by L-glutamate or hypoxia.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Brain; Cell Hypoxia; Cells, Cultured; Cyclic GMP; Dizocilpine Maleate; Fetus; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; N-Methylaspartate; Neuroglia; Neurons; Nitric Oxide; Nitroarginine; Nitroprusside; omega-N-Methylarginine; Quisqualic Acid; Rats | 1991 |
Glutamate-activated channels in adult rat ventral spinal cord cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Membrane; Chick Embryo; Glutamates; In Vitro Techniques; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Spinal Cord | 1991 |
Potentiation of a behavioural response in mice by spinal coadministration of substance P and excitatory amino acid agonists.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Analgesics; Animals; Behavior, Animal; Drug Synergism; Ibotenic Acid; Injections, Spinal; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Nociceptors; Piperazines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Substance P | 1991 |
Glutamate receptor agonist-induced inward currents in spinal dorsal horn neurons dissociated from the adult rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Ion Channels; Kainic Acid; N-Methylaspartate; Nerve Fibers; Neurons; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord | 1991 |
Mitogenic effects of excitatory amino acids in the adult rat retina.
Topics: Animals; Cell Count; Dose-Response Relationship, Drug; Kainic Acid; Male; Mitosis; N-Methylaspartate; Neuroglia; Ouabain; Quisqualic Acid; Rats; Retina | 1991 |
Excitatory and inhibitory amino acid binding sites in human dentate nucleus.
Topics: Adult; Aged; Amino Acids; Autoradiography; Binding Sites; Cerebellar Nuclei; Dizocilpine Maleate; gamma-Aminobutyric Acid; Humans; Kainic Acid; Middle Aged; N-Methylaspartate; Neural Inhibition | 1991 |
The actions of a conformationally restricted analogue of aspartic acid on mammalian spinal neurones.
Topics: Action Potentials; Animals; Aspartic Acid; Cycloleucine; Kainic Acid; Molecular Conformation; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Spinal Cord; Stereoisomerism | 1991 |
Development of intracellular calcium responses to depolarization and to kainate and N-methyl-D-aspartate in cultured mouse hippocampal neurons.
Topics: Aging; Animals; Calcium; Cells, Cultured; Hippocampus; Image Processing, Computer-Assisted; Kainic Acid; Magnesium; Membrane Potentials; Mice; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Video Recording | 1991 |
Non-NMDA antagonists protect against kainate more than AMPA toxicity in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Pyramidal Tracts; Quinoxalines; Rats; Rats, Inbred Strains | 1991 |
4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Ibotenic Acid; Indicators and Reagents; Kainic Acid; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; N-Methylaspartate; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Structure-Activity Relationship; Tetrazoles | 1991 |
GYKI 52466 antagonizes glutamate responses but not NMDA and kainate responses in rat abducens motoneurones.
Topics: Abducens Nerve; Animals; Anti-Anxiety Agents; Benzodiazepines; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamates; Kainic Acid; Male; Motor Neurons; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Neuroprotectant effects of LY274614, a structurally novel systemically active competitive NMDA receptor antagonist.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Female; Ibotenic Acid; Isoquinolines; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Quisqualic Acid; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Analysis of the convulsant-potentiating effects of lithium in rats.
Topics: Animals; Bicuculline; Chlorides; Convulsants; Drug Synergism; Hippocampus; Kainic Acid; Lithium; Lithium Chloride; Male; N-Methylaspartate; Pilocarpine; Rats; Rats, Inbred Strains; Seizures | 1991 |
Neuronal fodrin proteolysis occurs independently of excitatory amino acid-induced neurotoxicity.
Topics: Animals; Blotting, Northern; Calcium; Calcium Channels; Calpain; Carrier Proteins; Cattle; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Kainic Acid; Leupeptins; Microfilament Proteins; N-Methylaspartate; Neurons; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Time Factors | 1991 |
Permeation of calcium ions through non-NMDA glutamate channels in retinal bipolar cells.
Topics: Ambystoma; Animals; Calcium; Calcium Channels; Cell Membrane Permeability; Glutamates; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina | 1991 |
A rapid method to quantify neurons in mixed cultures based on the specific binding of [3H]ouabain to neuronal Na+,K(+)-ATPase.
Topics: Cell Survival; Cells, Cultured; Culture Techniques; Hippocampus; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Ouabain; Protein Binding; Radioisotope Dilution Technique; Sodium-Potassium-Exchanging ATPase; Tritium | 1991 |
GABA accelerates excitotoxic cell death in cortical cultures: protection by blockers of GABA-gated chloride channels.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Chloride Channels; Chlorides; gamma-Aminobutyric Acid; Ion Channel Gating; Kainic Acid; Membrane Proteins; N-Methylaspartate; Neurotoxins; Quisqualic Acid; Rats | 1991 |
GDP beta S antagonizes whole-cell current responses to excitatory amino acids.
Topics: Animals; Guanosine Diphosphate; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Rats; Retinal Ganglion Cells; Superior Colliculi; Thionucleotides | 1991 |
NMDA-, kainate- and quisqualate-stimulated release of taurine from electrophysiologically monitored rat hippocampal slices.
Topics: Animals; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Membrane Potentials; N-Methylaspartate; Perfusion; Pyramidal Tracts; Quisqualic Acid; Rats; Rats, Inbred Strains; Taurine | 1991 |
Calcium channel blockers and excitatory amino acids.
Topics: Amino Acids; Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Seizures | 1991 |
DNQX blockade of amphetamine behavioral sensitization.
Topics: Amphetamine; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Haloperidol; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Quinoxalines; Seizures; Stereotyped Behavior | 1991 |
Parallel development of excitotoxic vulnerability to N-methyl-D-aspartate and kainate in dispersed cultures of the rat cerebral cortex.
Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Female; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Pregnancy; Rats; Rats, Inbred Strains | 1991 |
2-Chloroadenosine attenuates NMDA, kainate, and quisqualate toxicity.
Topics: 2-Chloroadenosine; Animals; Corpus Striatum; Injections; Kainic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Inbred Strains | 1991 |
Pertussis toxin potentiates seizures induced by pilocarpine, kainic acid and N-methyl-D-aspartate.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Animals; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; GTP-Binding Proteins; Injections, Intraventricular; Kainic Acid; Lithium; Male; N-Methylaspartate; Pertussis Toxin; Pilocarpine; Rats; Rats, Inbred Strains; Seizures; Stereotaxic Techniques; Virulence Factors, Bordetella | 1991 |
Role of nitric oxide in the genesis of excitatory amino acid-induced seizures from the deep prepiriform cortex.
Topics: Animals; Arginine; Electric Stimulation; Electroencephalography; Kainic Acid; Male; Methylene Blue; N-Methylaspartate; Nitric Oxide; omega-N-Methylarginine; Rats; Rats, Inbred Strains; Seizures; Temporal Lobe | 1991 |
Topographical heterogeneity of glutamate agonist-induced calcium increase in hippocampus.
Topics: Animals; Calcium; Hippocampus; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Regulation of the NMDA receptor by redox phenomena: inhibitory role of ascorbate.
Topics: Animals; Ascorbic Acid; Cerebral Cortex; Dithiothreitol; Electrophysiology; In Vitro Techniques; Ion Channel Gating; Kainic Acid; Kinetics; Mercaptoethanol; N-Methylaspartate; Neurons; Oxidation-Reduction; Penicillamine; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Structure-activity relationship on excitatory amino acid receptors.
Topics: Central Nervous System; Humans; Kainic Acid; Models, Molecular; Molecular Conformation; N-Methylaspartate; Quisqualic Acid; Receptors, Neurotransmitter; Structure-Activity Relationship | 1990 |
Relationship between structure, conformational flexibility, and biological activity of agonists and antagonists at the N-methyl-D-aspartic acid subtype of excitatory amino acid receptors.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain; Computer Simulation; Ibotenic Acid; Kainic Acid; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Structure; N-Methylaspartate; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship | 1990 |
NMDA receptors mediate poly- and monosynaptic potentials in motoneurons of rat embryos.
Topics: Animals; Aspartic Acid; Electrophysiology; Glutamates; Glutamic Acid; Kainic Acid; Motor Neurons; N-Methylaspartate; Neurons, Afferent; Rats; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Nerve Roots; Synapses; Synaptic Transmission | 1990 |
Failure of sigma-receptor ligands to reduce the excitatory actions of N-methyl-DL-aspartate on rat spinal neurons in-vivo.
Topics: Animals; Aspartic Acid; Haloperidol; In Vitro Techniques; Kainic Acid; Ligands; N-Methylaspartate; Neurons; Oxadiazoles; Piperidines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord; Stereoisomerism | 1990 |
Induction of locomotion in spinal tadpoles by excitatory amino acids and their agonists.
Topics: Animals; Anura; Aspartic Acid; Glutamates; Glutamic Acid; Kainic Acid; Locomotion; Motor Activity; N-Methylaspartate; Spinal Cord; Swimming | 1990 |
Acute- and long-term glutamate-mediated regulation of [Ca++]i in rat hippocampal pyramidal neurons in vitro.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Differential expression of excitatory amino acid receptor subtypes in cultured cerebellar neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Oxadiazoles; Potassium Chloride; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Selective loss of N-methyl-D-aspartate-sensitive L-[3H]glutamate binding sites in rat brain following portacaval anastomosis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ammonia; Animals; Aspartic Acid; Brain; Cerebral Cortex; Corpus Striatum; Down-Regulation; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Kainic Acid; Liver; Male; N-Methylaspartate; Organ Size; Portacaval Shunt, Surgical; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Thalamus | 1990 |
Cortical neurons containing somatostatin- or parvalbumin-like immunoreactivity are atypically vulnerable to excitotoxic injury in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Fetus; Ibotenic Acid; Kainic Acid; L-Lactate Dehydrogenase; Mice; Muscle Proteins; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Oxazoles; Parvalbumins; Somatostatin | 1990 |
Mechanisms generating the time course of dual component excitatory synaptic currents recorded in hippocampal slices.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Electrophysiology; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Ketamine; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Temperature; Time Factors | 1990 |
Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate- and quisqualate-mediated depolarization of rat motoneurones in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Ganglia, Spinal; Hexamethonium Compounds; In Vitro Techniques; Kainic Acid; Motor Neurons; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Synapses; Tetrodotoxin | 1990 |
(2S,3S,4S) alpha-(carboxycyclopropyl)glycine is a novel agonist of metabotropic glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Dicarboxylic; Animals; Electric Stimulation; Ibotenic Acid; In Vitro Techniques; Inositol Phosphates; Kainic Acid; N-Methylaspartate; Piperazines; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred F344; Receptors, Glutamate; Receptors, Neurotransmitter; Synaptosomes | 1990 |
Action of the anti-ischemic agent ifenprodil on N-methyl-D-aspartate and kainate-mediated excitotoxicity.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Antagonists; Animals; Chick Embryo; gamma-Aminobutyric Acid; Kainic Acid; N-Methylaspartate; Neurons; Piperidines; Quinoxalines; Retina | 1990 |
Excitatory amino acid receptors of guinea pig medial nucleus tractus solitarius neurons.
Topics: Amino Acids; Animals; Glutamates; Glutamic Acid; Guinea Pigs; Kainic Acid; Medulla Oblongata; N-Methylaspartate; Neurons; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface | 1990 |
Glutamate, the dominant excitatory transmitter in neuroendocrine regulation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Axons; Calcium; Electric Stimulation; Glutamates; Glutamic Acid; Hypothalamus; Immunohistochemistry; Kainic Acid; Microscopy, Electron; N-Methylaspartate; Neurons; Neurotransmitter Agents; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Second Messenger Systems; Synapses | 1990 |
Excitatory amino acid receptor agonists stimulate membrane inositol phospholipid hydrolysis and increase cytoplasmic free Ca2+ in primary cultures of retinal neurons.
Topics: Amino Acids; Animals; Calcium; Cells, Cultured; Cyclic GMP; Cytoplasm; Glutamates; Glutamic Acid; Hydrolysis; Kainic Acid; N-Methylaspartate; Neurons; Phosphatidylinositols; Receptors, Amino Acid; Receptors, Cell Surface; Retina | 1990 |
Lack of excitotoxic cell death in serum-free cultures of rat cerebral cortex.
Topics: Amino Acids; Animals; Blood Physiological Phenomena; Cell Survival; Cells, Cultured; Cerebral Cortex; Culture Media; Glutamates; Glutamic Acid; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Inbred Strains | 1990 |
Excitotoxins can produce protein degradation in the spinal cord.
Topics: Animals; Calcium; Female; Glutamates; Glutamic Acid; Intermediate Filament Proteins; Kainic Acid; N-Methylaspartate; Neurofilament Proteins; Neurotoxins; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1990 |
Glutamate- and aspartate-induced extracellular potassium and calcium shifts and their relation to those of kainate, quisqualate and N-methyl-D-aspartate in the isolated turtle cerebellum.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cerebellum; Dose-Response Relationship, Drug; Extracellular Space; Glutamates; Glutamic Acid; In Vitro Techniques; Iontophoresis; Kainic Acid; Manganese; N-Methylaspartate; Potassium; Quisqualic Acid; Turtles | 1990 |
Receptor site specificity for the acute effects of beta-N-methylamino-alanine in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Cyanobacteria Toxins; Glutamine; Ibotenic Acid; Injections, Intraventricular; Kainic Acid; Kinetics; Male; Mice; N-Methylaspartate; Organophosphorus Compounds; Piperazines; Receptors, Drug; Receptors, N-Methyl-D-Aspartate | 1990 |
Initiation of swimming activity in the medicinal leech by glutamate, quisqualate and kainate.
Topics: Animals; Glutamates; Glutamic Acid; Kainic Acid; Leeches; Motor Activity; N-Methylaspartate; Quisqualic Acid; Swimming | 1990 |
Characterization of Ca2(+)-mobilizing excitatory amino acid receptors in cultured chick cortical cells.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Chick Embryo; Glutamates; Glutamic Acid; Immunohistochemistry; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate | 1990 |
Neurotoxic effects of excitatory amino acids in the mouse spinal cord: quisqualate and kainate but not N-methyl-D-aspartate induce permanent neural damage.
Topics: 2-Amino-5-phosphonovalerate; Aggression; Animals; Glutamine; Kainic Acid; Male; Mice; Mice, Inbred ICR; Motor Activity; N-Methylaspartate; Neurons; Neurotoxins; Pain; Paralysis; Quisqualic Acid; Spinal Cord | 1990 |
Actions of excitatory amino acids on brisk ganglion cells in the cat retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Anesthesia; Animals; Aspartic Acid; Cats; Electrodes; Glutamates; Glutamic Acid; Ibotenic Acid; Iontophoresis; Kainic Acid; N-Methylaspartate; Photic Stimulation; Quisqualic Acid; Retinal Ganglion Cells | 1990 |
Selective reduction of quisqualate (AMPA) receptors in Alzheimer cerebellum.
Topics: Aged; Aged, 80 and over; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Autoradiography; Cerebellum; Female; Glutamates; Glutamic Acid; Humans; Ibotenic Acid; Kainic Acid; Kinetics; Male; N-Methylaspartate; Radioligand Assay; Receptors, AMPA; Receptors, Neurotransmitter | 1990 |
Cytotoxic effect of glutamate and its agonists on mouse hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Cells, Cultured; Dipeptides; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Pregnancy; Quinolinic Acid; Quinolinic Acids | 1990 |
N-methyl-D-aspartate, kainate and quisqualate release endogenous adenosine from rat cortical slices.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Adenosine; Animals; Calcium; Cerebral Cortex; Dipeptides; Dizocilpine Maleate; In Vitro Techniques; Kainic Acid; Kinetics; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Tetrodotoxin | 1990 |
Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; Aged; Autoradiography; Female; Glutamates; Hippocampus; Humans; Kainic Acid; Male; Middle Aged; N-Methylaspartate; Pyramidal Tracts; Quinoxalines; Receptors, Glutamate; Receptors, Neurotransmitter; Reference Values; Schizophrenia; Tritium | 1990 |
Ethanol inhibition of NMDA mediated depolarizations is increased in the presence of Mg2+.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Ethanol; Female; Glycine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Magnesium; N-Methylaspartate; Neuromuscular Depolarizing Agents; Rats; Rats, Inbred Strains | 1991 |
A quantitative analysis of the effects of excitatory neurotoxins on retinal ganglion cells in the chick.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Survival; Chickens; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Retina; Retinal Ganglion Cells; Vitreous Body | 1990 |
Philanthotoxin blocks quisqualate-, AMPA- and kainate-, but not NMDA-, induced excitation of rat brainstem neurones in vivo.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Stem; Female; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Polyamines; Quisqualic Acid; Rats; Rats, Inbred Strains; Wasp Venoms | 1990 |
Inhibition of N-methyl-D-aspartate-induced noradrenaline release by alcohols is related to their hydrophobicity.
Topics: Alcohols; Animals; Cerebellar Cortex; Ethanol; Kainic Acid; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains | 1990 |
Effects of hypoxia and hypoglycaemia on DC potentials recorded from the gerbil hippocampus in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cell Hypoxia; gamma-Aminobutyric Acid; Gerbillinae; Hippocampus; Hypoglycemia; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Male; Membrane Potentials; N-Methylaspartate | 1990 |
Differential effects of antiepileptic drugs and beta-carbolines on seizures induced by excitatory amino acids.
Topics: Animals; Anticonvulsants; Carbolines; Convulsants; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Quisqualic Acid; Seizures | 1990 |
NMDA antagonist properties of gamma-L-glutamyl-L-aspartate demonstrated on chemically induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dipeptides; Dose-Response Relationship, Drug; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Seizures | 1990 |
A study in rat brain cortex synaptic vesicles of endogenous ligands for N-methyl-D-aspartate receptors.
Topics: Amino Acids; Animals; Cerebral Cortex; Chromatography, Gel; Chromatography, High Pressure Liquid; Electrophoresis; Glutamates; In Vitro Techniques; Kainic Acid; Ligands; N-Methylaspartate; Quisqualic Acid; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptic Vesicles; Tissue Extracts; Ultracentrifugation | 1990 |
Serotonin suppresses N-methyl-D-aspartate responses in acutely isolated spinal dorsal horn neurons of the rat.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Drug Synergism; Glycine; In Vitro Techniques; Indoles; Kainic Acid; Ketanserin; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin Antagonists; Spinal Cord; Tetrahydronaphthalenes; Tropisetron | 1990 |
NADPH-diaphorase reactive neurons of the rabbit retina: differential sensitivity to excitotoxins and unusual morphologic features.
Topics: Animals; Eye Proteins; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; NADPH Dehydrogenase; Neurons; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Rabbits; Retina; Vitreous Body | 1990 |
Elevation of Met-enkephalin-like immunoreactivity in the rat striatum and globus pallidus following the focal injection of excitotoxins.
Topics: Animals; Corpus Striatum; Enkephalin, Methionine; Globus Pallidus; Huntington Disease; Injections; Kainic Acid; Male; N-Methylaspartate; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Radioimmunoassay; Rats; Rats, Inbred Strains | 1990 |
Excitatory amino acid receptors on sustained retinal ganglion cells in the kitten during the critical period of development.
Topics: Action Potentials; Aging; Animals; Aspartic Acid; Cats; Kainic Acid; N-Methylaspartate; Oxadiazoles; Photic Stimulation; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Retina; Retinal Ganglion Cells; Visual Pathways | 1990 |
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; Kainic Acid; Kynurenic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Oxadiazoles; Phencyclidine; Pyrrolidinones; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Pyramidal Tracts; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1990 |
Glutamate receptor agonists cause efflux of endogenous neuroactive amino acids from cerebellar neurons in culture.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Calcium Channels; Drug Antagonism; Ibotenic Acid; In Vitro Techniques; Ion Channel Gating; Kainic Acid; Mice; N-Methylaspartate; Neurons; Nifedipine; Quinolinic Acid; Quinolinic Acids; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Stimulatory and inhibitory actions of excitatory amino acids on inositol phospholipid metabolism in rabbit retina. Evidence for a specific quisqualate receptor subtype associated with neurones.
Topics: Animals; Aspartic Acid; Calcium; Carbachol; Dose-Response Relationship, Drug; Ibotenic Acid; In Vitro Techniques; Inositol Phosphates; Kainic Acid; N-Methylaspartate; Norepinephrine; Oxadiazoles; Quisqualic Acid; Rabbits; Receptors, AMPA; Receptors, Neurotransmitter; Retina | 1990 |
6,7-Dinitroquinoxaline-2,3-dione blocks the cytotoxicity of N-methyl-D-aspartate and kainate, but not quisqualate, in cortical cultures.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Hippocampus; Kainic Acid; Ligands; N-Methylaspartate; Neurotoxins; Norepinephrine; Oxadiazoles; Quinoxalines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
N-methyl-D-aspartate-induced neuronal activation is selectively modulated by sigma receptors.
Topics: Animals; Aspartic Acid; Guanidines; Haloperidol; In Vitro Techniques; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Spiperone | 1990 |
Excitatory amino acids and cardiovascular apparatus: experimental studies on conscious rats with L-glutamate, N-methyl-D-aspartate, kainate and quisqualate.
Topics: Amino Acids; Animals; Aspartic Acid; Cardiovascular Physiological Phenomena; Cardiovascular System; Glutamates; Injections, Intraventricular; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Synaptic Transmission | 1990 |
Glutamate-receptor-mediated regulation of the cytoplasmic free calcium level in cultured cerebellar granule cells.
Topics: Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Cytoplasm; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glutamates; Glycine; Kainic Acid; Magnesium; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Glycine; Hippocampus; Kainic Acid; Kinetics; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship | 1990 |
Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Brain; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Stereoisomerism | 1990 |
Pre- and postsynaptic excitatory action of glutamate agonists on frog vestibular receptors.
Topics: Afferent Pathways; Animals; Aspartic Acid; Glutamates; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rana esculenta; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission; Vestibule, Labyrinth | 1990 |
Glutaminergic responses of neuropile glial cells and Retzius neurones in the leech central nervous system.
Topics: Animals; Central Nervous System; Glutamine; Kainic Acid; Leeches; Magnesium; Membrane Potentials; Microelectrodes; N-Methylaspartate; Neuroglia; Neuromuscular Depolarizing Agents; Neurons; Potassium; Quisqualic Acid; Sodium; Synaptic Transmission; Tubocurarine | 1990 |
Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors.
Topics: Animals; Blotting, Northern; Brain-Derived Neurotrophic Factor; Cells, Cultured; Dose-Response Relationship, Drug; Gene Expression; Glutamates; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Potassium; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger | 1990 |
Excitatory amino acid response in isolated nucleus tractus solitarii neurons of the rat.
Topics: Amino Acids; Animals; Aspartic Acid; Electrophysiology; Glycine; In Vitro Techniques; Kainic Acid; Medulla Oblongata; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1990 |
Selective stimulation of excitatory amino acid receptor subtypes and the survival of cerebellar granule cells in culture: effect of kainic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Survival; Cells, Cultured; Cerebellum; Dipeptides; Dizocilpine Maleate; DNA; Electric Stimulation; Glutamine; Ibotenic Acid; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Potassium; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1990 |
Interactive effects involving different classes of excitatory amino acid receptors and the survival of cerebellar granule cells in culture.
Topics: Amino Acids; Animals; Calcium Channel Blockers; Cell Survival; Cells, Cultured; Cerebellum; Extracellular Space; Granulocytes; Kainic Acid; N-Methylaspartate; Potassium; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate | 1990 |
Dopamine release in the nucleus caudatus and in the nucleus accumbens is under glutamatergic control through non-NMDA receptors: a study in freely-moving rats.
Topics: Animals; Behavior, Animal; Caudate Nucleus; Dialysis; Dopamine; Glutamates; Haloperidol; Kainic Acid; Male; N-Methylaspartate; Nucleus Accumbens; Piperazines; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Efflux of 45calcium from cultured primary astrocytes: effects of glutamate receptor agonists and antagonists.
Topics: Animals; Animals, Newborn; Astrocytes; Calcium; Calcium Radioisotopes; Cells, Cultured; Excitatory Amino Acid Antagonists; Glutamates; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Valine | 1990 |
Conantokin-G: a novel peptide antagonist to the N-methyl-D-aspartic acid (NMDA) receptor.
Topics: Amino Acid Sequence; Animals; Conotoxins; Cyclic GMP; Glutamates; Glycine; In Vitro Techniques; Kainic Acid; Molecular Sequence Data; N-Methylaspartate; Peptides, Cyclic; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 1990 |
Non-NMDA receptor mediates cytoplasmic Ca2+ elevation in cultured hippocampal neurones.
Topics: Animals; Calcium; Calcium Channels; Cells, Cultured; Culture Media; Cytoplasm; Hippocampus; Image Processing, Computer-Assisted; Kainic Acid; N-Methylaspartate; Neurons; Potassium Chloride; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Sodium; Spectrometry, Fluorescence; Synapses; Synaptic Transmission | 1990 |
N-methyl-D-aspartate antagonism and phencyclidine-like activity: a drug discrimination analysis.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Injections, Intraperitoneal; Kainic Acid; Male; Mice; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains | 1990 |
Role of endogenous taurine on the glutamate analogue-induced neurotoxicity in the rat hippocampus in vivo.
Topics: Animals; Aspartic Acid; Extracellular Space; Hippocampus; Kainic Acid; N-Methylaspartate; Osmolar Concentration; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Sucrose; Taurine | 1990 |
Microionophoretic study with milacemide, a glycine precursor, on mammalian central nervous system cells.
Topics: Acetamides; Animals; Aspartic Acid; Brain; Cats; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glycine; Iontophoresis; Kainic Acid; Monoamine Oxidase Inhibitors; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid | 1990 |
GABA does not protect cerebro-cortical cultures against excitotoxic cell death.
Topics: Animals; Aspartic Acid; Cell Survival; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Glutamates; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurotoxins; Oxadiazoles; Pregnancy; Quisqualic Acid; Rats; Rats, Inbred Strains | 1990 |
Neuropeptide Y selectively potentiates N-methyl-D-aspartate-induced neuronal activation.
Topics: Animals; Aspartic Acid; Drug Synergism; Haloperidol; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; Neuropeptide Y; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains | 1990 |
Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake.
Topics: Animals; Biological Transport, Active; Brain Diseases; Extracellular Space; Glutamates; Hypoxia; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neuroglia; Neurons; Potassium; Urodela | 1990 |
Sympathetic preganglionic neurones in neonatal rat spinal cord in vitro: electrophysiological characteristics and the effects of selective excitatory amino acid receptor agonists.
Topics: Animals; Animals, Newborn; Calcium; Evoked Potentials; Ganglia, Sympathetic; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Inbred Strains; Spinal Cord; Synapses; Tetraethylammonium; Tetraethylammonium Compounds | 1990 |
[The distribution of kainate and quisqualate receptors in the rat cerebellum].
Topics: Aminobutyrates; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Kainic Acid; Membrane Potentials; N-Methylaspartate; Purkinje Cells; Quisqualic Acid; Rats; Receptors, Drug | 1990 |
Transneuronal degeneration in the midbrain central gray following chemical lesions in the ventromedial nucleus: a qualitative and quantitative analysis.
Topics: Animals; Cerebral Cortex; Female; Kainic Acid; Mesencephalon; N-Methylaspartate; Nerve Degeneration; Neurons; Parietal Lobe; Periaqueductal Gray; Rats; Rats, Inbred Strains; Synapses; Ventromedial Hypothalamic Nucleus | 1990 |
Kainic acid on neostriatal neurons intracellularly recorded in vitro: electrophysiological evidence for differential neuronal sensitivity.
Topics: Action Potentials; Animals; Cell Membrane; Corpus Striatum; Dose-Response Relationship, Drug; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Nerve Degeneration; Neural Conduction; Neurons; Quisqualic Acid; Rats; Rats, Inbred Strains | 1990 |
Suppression by extracellular K+ of N-methyl-D-aspartate responses in cultured rat hippocampal neurons.
Topics: Animals; Cells, Cultured; Cesium; Glycine; Hippocampus; Iontophoresis; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Potassium; Quisqualic Acid; Rats | 1990 |
Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Glutamates; Kainic Acid; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Neurotoxins | 1990 |
Remodelling of intrinsic and afferent systems in neocortex with cortical transplants.
Topics: Afferent Pathways; Animals; Atrophy; Behavior, Animal; Brain Tissue Transplantation; Cerebral Cortex; Fetal Tissue Transplantation; Kainic Acid; Motor Activity; N-Methylaspartate; Rats | 1990 |
Comparison of anticonvulsant effect of ethanol against NMDA-, kainic acid- and picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Ethanol; Kainic Acid; Male; N-Methylaspartate; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1990 |
Kainic acid responses and toxicity show pronounced Ca2+ dependence.
Topics: Animals; Aspartic Acid; Calcium; Drug Interactions; In Vitro Techniques; Ion Channels; Iontophoresis; Kainic Acid; Limbic System; Magnesium; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats | 1985 |
Evidence that excitatory amino acids not only activate the receptor channel complex but also lead to use-dependent block.
Topics: Amino Acids; Animals; Aspartic Acid; Chick Embryo; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Neurotransmitter; Spinal Cord | 1986 |
Phencyclidine selectively blocks a spinal action of N-methyl-D-aspartate in mice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glutamates; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Norepinephrine; Oxadiazoles; Phencyclidine; Quisqualic Acid; Spinal Cord; Substance P; Tetrazoles; Valine | 1986 |
Characterization of excitatory amino acid receptors expressed by embryonic chick motoneurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamates; In Vitro Techniques; Ion Channels; Kainic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Valine | 1986 |
Use-dependent block of excitatory amino acid currents in cultured neurons by ketamine.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Electric Conductivity; Glutamates; Glutamic Acid; Hippocampus; Ion Channels; Kainic Acid; Ketamine; Membrane Potentials; Mice; N-Methylaspartate; Spinal Cord | 1987 |
Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.
Topics: Action Potentials; Animals; Anticonvulsants; Aspartic Acid; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Ion Channels; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Visual Cortex | 1988 |
The effect of intracellular tetraethylammonium ions on the reversal potential of monosynaptic EPSPs and excitatory amino acids in cultured spinal cord neurones.
Topics: Animals; Aspartic Acid; Cells, Cultured; Dendrites; Ion Channels; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Reflex, Monosynaptic; Spinal Cord; Synapses; Tetraethylammonium Compounds | 1988 |
Noise and single channels activated by excitatory amino acids in rat cerebellar granule neurones.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1988 |
Differences in the pore sizes of the N-methyl-D-aspartate and kainate cation channels.
Topics: Animals; Aspartic Acid; Brain; Calcium; Cations; Cell Membrane Permeability; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Strontium | 1988 |
N-methyl-D-aspartate activates different channels than do kainate and quisqualate.
Topics: Animals; Aspartic Acid; Brain Chemistry; Electric Conductivity; Female; Ion Channels; Kainic Acid; Magnesium; Male; N-Methylaspartate; Oocytes; Oxadiazoles; Phencyclidine; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1989 |
Ethanol inhibits NMDA-activated ion current in hippocampal neurons.
Topics: 1-Butanol; Aspartic Acid; Butanols; Calcium Channels; Chloride Channels; Chlorides; Electric Conductivity; Ethanol; gamma-Aminobutyric Acid; Hippocampus; Humans; Ion Channels; Kainic Acid; Membrane Proteins; Methanol; N-Methylaspartate; Neurons; Oxadiazoles; Pentanols; Quisqualic Acid; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium Channels | 1989 |
Muscimol, gamma-aminobutyric acidA receptors and excitatory amino acids in the mouse spinal cord.
Topics: Analgesia; Animals; Aspartic Acid; Baclofen; Behavior, Animal; Bicuculline; Kainic Acid; Male; Mice; Muscimol; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, GABA-A; Spinal Cord; Substance P | 1989 |
Unique properties of non-N-methyl-D-aspartate excitatory responses in cultured purkinje neurons.
Topics: Action Potentials; Animals; Aspartic Acid; Cadmium; Calcium; Cations, Divalent; Choline; Electric Conductivity; Ion Channels; Kainic Acid; Kynurenic Acid; Magnesium; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Sucrose; Tetrodotoxin | 1989 |
Multiple conductance channels in type-2 cerebellar astrocytes activated by excitatory amino acids.
Topics: Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Cerebellum; Convulsants; Electric Conductivity; Evoked Potentials; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Synaptic Transmission | 1989 |
Excitatory and inhibitory amino acids and peptide-induced responses in acutely isolated rat spinal dorsal horn neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Drug Synergism; Electric Conductivity; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neuropeptides; Oxadiazoles; Peptides; Quisqualic Acid; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1989 |
Cloning by functional expression of a member of the glutamate receptor family.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; Brain Chemistry; Cloning, Molecular; DNA; Electrophysiology; Gene Expression; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Molecular Sequence Data; Molecular Weight; N-Methylaspartate; Oocytes; Plasmids; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; RNA; Tissue Distribution; Transcription, Genetic; Transfection; Xenopus | 1989 |
Differential effects of excitatory amino acids on photoreceptors of the chick retina: an electron-microscopical study using the zinc-iodide-osmium technique.
Topics: Amino Acids; Animals; Histological Techniques; Iodides; Kainic Acid; Microscopy, Electron; N-Methylaspartate; Osmium; Photoreceptor Cells; Quisqualic Acid; Reference Values; Retina; Time Factors; Zinc | 1989 |
Excitotoxicity of NMDA and kainic acid is modulated by nigrostriatal dopaminergic fibres.
Topics: Animals; Aspartic Acid; Choline O-Acetyltransferase; Corpus Striatum; Dopamine; Glutamate Decarboxylase; Hydroxydopamines; Kainic Acid; N-Methylaspartate; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra | 1989 |
[Excitotoxic damage of the hippocampus in the rat: involvement of N-methyl-D-aspartate receptors].
Topics: Animals; Aspartic Acid; Hippocampus; Illicit Drugs; Kainic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains | 1989 |
Effects of excitatory amino acid receptor antagonists and agonists on suprachiasmatic nucleus responses to retinohypothalamic tract volleys.
Topics: Animals; Aspartic Acid; Hypothalamus; In Vitro Techniques; Kainic Acid; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Optic Nerve; Pipecolic Acids; Receptors, Amino Acid; Receptors, Cell Surface; Retina; Retinal Ganglion Cells; Suprachiasmatic Nucleus | 1989 |
In primary cultures of cerebellar granule cells the activation of N-methyl-D-aspartate-sensitive glutamate receptors induces c-fos mRNA expression.
Topics: Animals; Aspartic Acid; Blotting, Northern; Calcium; Cells, Cultured; Cerebellum; Gene Expression Regulation; Glutamates; Glycine; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Oxadiazoles; Phencyclidine; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Transcription, Genetic | 1989 |
Pharmacological characterization of the glutamate receptor in cultured astrocytes.
Topics: Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Kainic Acid; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1989 |
Direct activation of gonadotropin-releasing hormone secretion through different receptors to neuroexcitatory amino acids.
Topics: Animals; Aspartic Acid; Hypothalamus; Kainic Acid; Luteinizing Hormone; Male; N-Methylaspartate; Pituitary Hormone-Releasing Hormones; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Modulation of NMDA receptor-mediated responses by glycine and D-serine in the rat thalamus in vivo.
Topics: Action Potentials; Animals; Aspartic Acid; Glycine; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Strychnine; Thalamus | 1989 |
Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage.
Topics: Animals; Aspartic Acid; Calpain; Colchicine; Dose-Response Relationship, Drug; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Neurotoxins; Peptide Hydrolases; Rats; Rats, Inbred Strains; Spectrin; Time Factors; Tissue Distribution | 1989 |
Pulsatile release of gonadotropin-releasing hormone from hypothalamic explants is restrained by blockade of N-methyl-D,L-aspartate receptors.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Hypothalamus; Kainic Acid; Magnesium; Male; N-Methylaspartate; Pituitary Hormone-Releasing Hormones; Rats; Rats, Inbred Strains; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Beta-N-oxalylamino-L-alanine action on glutamate receptors.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; Aspartic Acid; beta-Alanine; Binding, Competitive; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Hippocampus; Ibotenic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Oxadiazoles; Piperazines; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Synaptic Membranes; Thiocyanates | 1989 |
Neurotoxicity of excitatory amino acid receptor agonists in young rat hippocampal slices.
Topics: Animals; Aspartic Acid; Female; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Neurotoxins; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Time Factors | 1989 |
Selectivity of quinoxalines and kynurenines as antagonists of the glycine site on N-methyl-D-aspartate receptors.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Biological Assay; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship; Xenopus laevis | 1989 |
Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cycloleucine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 DNA binding activity in the mammalian brain.
Topics: Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Blotting, Northern; Convulsants; DNA-Binding Proteins; Electroshock; Gene Expression Regulation; Immunoblotting; Kainic Acid; Male; Mice; Mice, Inbred BALB C; N-Methylaspartate; Nucleic Acid Hybridization; Pentylenetetrazole; Picrotoxin; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Seizures; Transcription Factors | 1989 |
Ca2+-mediated neuronal death in rat brain neuronal cultures by veratridine: protection by flunarizine.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Flunarizine; Glutamates; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Rats; Sodium Channels; Tetrodotoxin; Veratridine; Veratrine | 1989 |
A quantitative description of excitatory amino acid neurotransmitter responses on cultured embryonic Xenopus spinal neurons.
Topics: Animals; Aspartic Acid; Embryo, Nonmammalian; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Xenopus laevis | 1989 |
Properties of excitatory amino acid receptors on sustained ganglion cells in the cat retina.
Topics: Action Potentials; Animals; Aspartic Acid; Cats; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Retina; Retinal Ganglion Cells | 1989 |
Reduced neuroexcitatory effect of domoic acid following mossy fiber denervation of the rat dorsal hippocampus: further evidence that toxicity of domoic acid involves kainate receptor activation.
Topics: Animals; Aspartic Acid; Colchicine; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Pyramidal Tracts; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1989 |
Non-N-methyl-D-aspartate receptors may mediate ipsilateral excitation at lateral superior olivary synapses.
Topics: Acoustic Stimulation; Action Potentials; Animals; Aspartic Acid; Auditory Pathways; Chinchilla; Dose-Response Relationship, Drug; Functional Laterality; Kainic Acid; N-Methylaspartate; Olivary Nucleus; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Kainate evokes the release of endogenous glycine from striatal neurons in primary culture.
Topics: Animals; Aspartic Acid; Cells, Cultured; Corpus Striatum; Glycine; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Glutamate receptor subtypes may be classified into two major categories: a study on Xenopus oocytes injected with rat brain mRNA.
Topics: Animals; Aspartic Acid; Brain Chemistry; Electrophysiology; Glutamates; Homocysteine; Ibotenic Acid; Kainic Acid; Microinjections; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus | 1989 |
Increased response of cerebellar cGMP to kainate but not NMDA or quisqualate following barbital withdrawal from dependent rats.
Topics: Animals; Aspartic Acid; Barbital; Barbiturates; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Female; Injections, Intraventricular; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
Attenuation of neurotoxicity following anoxia or glutamate receptor activation in EGF- and hippocampal extract-treated neuronal cultures.
Topics: Adenylyl Cyclases; Animals; Aspartic Acid; Cell Differentiation; Cell Survival; Cells, Cultured; Epidermal Growth Factor; Growth Substances; Hippocampus; Hypoxia, Brain; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Oxygen; Potassium Cyanide; Rats; Receptors, Adrenergic, beta; Receptors, Glutamate; Receptors, Neurotransmitter | 1989 |
L-[3H]glutamate binding to a membrane preparation from crayfish muscle.
Topics: Animals; Aspartic Acid; Astacoidea; Binding, Competitive; Calcium; Cell Membrane; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Muscles; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Stereoisomerism | 1989 |
Modulation of dendritic release of dopamine by N-methyl-D-aspartate receptors in rat substantia nigra.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Dendrites; Dopamine; Glutamates; Glutamic Acid; Glycine; Kainic Acid; Kinetics; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Substantia Nigra; Tetrodotoxin | 1989 |
Differential sparing of somatostatin-neuropeptide Y and cholinergic neurons following striatal excitotoxin lesions.
Topics: Animals; Aspartic Acid; Cholinergic Fibers; Corpus Striatum; Dose-Response Relationship, Drug; Kainic Acid; Male; N-Methylaspartate; NADPH Dehydrogenase; Neuropeptide Y; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Somatostatin | 1989 |
N-methyl-D-aspartate/glycine and quisqualate/kainate receptors expressed in Xenopus oocytes: antagonist pharmacology.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Kainic Acid; N-Methylaspartate; Oocytes; Quinoxalines; Receptors, AMPA; Receptors, Glycine; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1989 |
Pharmacological characterization of voltage-clamped catfish rod horizontal cell responses to kainic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Catfishes; Convulsants; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kinetics; N-Methylaspartate; Oxadiazoles; Photoreceptor Cells; Quisqualic Acid | 1989 |
Excitatory amino acid-evoked release of [3H]GABA from hippocampal neurons in primary culture.
Topics: Animals; Aspartic Acid; Cells, Cultured; Ethers; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Ionomycin; Kainic Acid; N-Methylaspartate; Rats; Rats, Inbred Strains; Veratridine; Zinc | 1989 |
Changes in excitatory amino acid receptor binding in the intact and decorticated rat neostriatum following insulin-induced hypoglycemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain; Caudate Nucleus; Cerebral Cortex; Corpus Striatum; Frontal Lobe; Glutamates; Glutamic Acid; Hypoglycemia; Ibotenic Acid; Insulin; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Regulation of Ca++ influx into striatal neurons by kainic acid.
Topics: Animals; Aspartic Acid; Calcium; Calcium Channels; Corpus Striatum; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Potassium; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium | 1989 |
6-Cyano-7-nitroquinoxaline-2,3-dione as an excitatory amino acid antagonist in area CA1 of rat hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Female; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Synapses | 1989 |
Auditory nerve neurotransmitter acts on a kainate receptor: evidence from intracellular recordings in brain slices from mice.
Topics: Action Potentials; Animals; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Mice; Mice, Inbred CBA; N-Methylaspartate; Receptors, Glutamate; Receptors, Neurotransmitter; Vestibulocochlear Nerve | 1989 |
Excitatory amino acid receptors in rat locus coeruleus. An extracellular in vitro study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Glutamates; In Vitro Techniques; Kainic Acid; Locus Coeruleus; Magnesium; Male; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Valine | 1989 |
Visual responses in adult cat visual cortex depend on N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Cats; Electric Conductivity; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine; Visual Cortex; Visual Perception | 1989 |
Biochemical characterization of an autoradiographic method for studying excitatory amino acid receptors using L-[3H]glutamate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Binding, Competitive; Brain; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Kinetics; Male; N-Methylaspartate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Software; Tritium | 1989 |
CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) antagonizes NMDA-evoked [3H]GABA release from cultured cortical neurons via an inhibitory action at the strychnine-insensitive glycine site.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1989 |
Glutamate receptor activation in cultured cerebellar granule cells increases cytosolic free Ca2+ by mobilization of cellular Ca2+ and activation of Ca2+ influx.
Topics: Animals; Aspartic Acid; Benzofurans; Calcium; Calcium Channel Blockers; Cells, Cultured; Cerebellum; Cytosol; Fluorescent Dyes; Fura-2; Glutamates; Glutamic Acid; Inositol Phosphates; Kainic Acid; Mice; N-Methylaspartate; Receptors, Glutamate; Receptors, Neurotransmitter; Spectrometry, Fluorescence | 1989 |
A grease-gap method for studying the excitatory amino acid pharmacology of CA1 hippocampal pyramidal cells.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Electrophysiology; Female; Glutamates; Hippocampus; Ibotenic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Phencyclidine; Rats; Rats, Inbred Strains; Valine | 1989 |
Lack of excitatory amino acid-induced effects on calcium fluxes measured with 45Ca2+ in rat cerebral cortex synaptosomes.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Calcium Radioisotopes; Cerebral Cortex; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Magnesium; Male; N-Methylaspartate; Potassium; Rats; Rats, Inbred Strains; Synaptosomes; Temperature | 1989 |
Extracellular taurine increase in rat hippocampus evoked by specific glutamate receptor activation is related to the excitatory potency of glutamate agonists.
Topics: Action Potentials; Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1989 |
Coexistence of NMDA and non-NMDA receptors on turtle horizontal cells revealed using isolated retina preparations.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Evoked Potentials, Visual; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Turtles; Valine | 1989 |
Quantitative physiological characterization of a quinoxalinedione non-NMDA receptor antagonist.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Hippocampus; Kainic Acid; Mathematics; N-Methylaspartate; Neurons; Oxadiazoles; Quinoxalines; Quisqualic Acid; Synapses | 1989 |
Inhibition of rat brain glutamate receptors by philanthotoxin.
Topics: Animals; Aspartic Acid; Bee Venoms; Brain; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Wasp Venoms; Xenopus | 1989 |
Inhibition of excitatory amino acid-stimulated phosphoinositide hydrolysis in the neonatal rat hippocampus by 2-amino-3-phosphonopropionate.
Topics: Alanine; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Carbachol; Chlorides; Hippocampus; Hydrolysis; Ibotenic Acid; In Vitro Techniques; Inositol; Kainic Acid; Kinetics; Lithium; Lithium Chloride; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains | 1989 |
Excitatory amino acid receptor-mediated activation of solitarial deglutitive loci.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Deglutition; Dipeptides; Esophagus; Glutamates; Kainic Acid; Male; Medulla Oblongata; N-Methylaspartate; Oxadiazoles; Pharynx; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Different classes of glutamate receptors mediate distinct behaviors in a single brainstem nucleus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Brain Stem; Electric Fish; Electric Organ; Glutamates; Glutamic Acid; Glutamine; Kainic Acid; N-Methylaspartate; Oxadiazoles; Pipecolic Acids; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1989 |
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.
Topics: Animals; Arginine; Aspartic Acid; Cerebellum; Citrulline; Cyclic GMP; Glutamates; Glutamic Acid; Hemoglobins; In Vitro Techniques; Kainic Acid; Kinetics; N-Methylaspartate; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Quisqualic Acid; Rats | 1989 |
Inhibition of N-methyl-D-aspartate- and kainic acid-induced neurotransmitter release by omega-conotoxin GVIA.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mollusk Venoms; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; omega-Conotoxin GVIA; Rats; Rats, Inbred Strains | 1989 |
Selective inhibition of excitatory amino acids by divalent cations. A novel means for distinguishing N-methyl-D-aspartic acid-, kainate- and quisqualate-mediated actions in the mouse spinal cord.
Topics: Animals; Aspartic Acid; Behavior, Animal; Calcium; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; Male; Mice; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Spinal Cord; Zinc | 1989 |
Glial uptake of excitatory amino acids influences neuronal survival in cultures of mouse hippocampus.
Topics: Action Potentials; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Culture Media; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuroglia; Phosphopyruvate Hydratase; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
The action of N-methyl-D-aspartic acid on mouse spinal neurones in culture.
Topics: Action Potentials; Animals; Aspartic Acid; Cells, Cultured; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Spinal Cord; Time Factors | 1985 |
Homocysteic acid: convulsant action of stereoisomers in mice.
Topics: Animals; Aspartic Acid; Convulsants; Homocysteine; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Seizures; Stereoisomerism | 1989 |
In vivo electrochemical studies of the effects of N-methyl-D-aspartate (NMDA) on dopamine nerve terminals in the neostriatum of the anesthetized rat.
Topics: Anesthesia; Animals; Aspartic Acid; Corpus Striatum; Dopamine; Electrochemistry; Kainic Acid; Male; N-Methylaspartate; Nerve Endings; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1989 |
Excitatory amino acids interfere with normal eye growth in posthatch chick.
Topics: Animals; Anterior Chamber; Aspartic Acid; Chickens; Eye; Kainic Acid; N-Methylaspartate; Organ Size; Oxadiazoles; Quisqualic Acid; Retina; Time Factors | 1989 |
Excitotoxin-induced myocardial necrosis.
Topics: Animals; Aspartic Acid; Blood Pressure; Cardiomyopathies; Heart Rate; Hypothalamus, Middle; Injections; Injections, Intraventricular; Kainic Acid; Male; Myocardium; N-Methylaspartate; Necrosis; Rats; Rats, Inbred Strains | 1989 |
Kynurenic acid microinjected into the nucleus tractus solitarius of rat blocks the arterial baroreflex but not responses to glutamate.
Topics: Acetylcholine; Animals; Arteries; Aspartic Acid; Blood Pressure; Excitatory Amino Acid Antagonists; Glutamates; Histocytochemistry; Kainic Acid; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; N-Methylaspartate; Oxadiazoles; Pressoreceptors; Quisqualic Acid; Rats; Rats, Inbred Strains; Reflex | 1989 |
AMPA, kainic acid, and N-methyl-D-aspartic acid stimulate locomotor activity after injection into the substantia innominata/lateral preoptic area.
Topics: 2-Aminoadipic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Basal Ganglia; Dose-Response Relationship, Drug; Drug Interactions; Glutamine; Ibotenic Acid; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Oxazoles; Preoptic Area; Quinoxalines; Rats; Rats, Inbred Strains; Substantia Innominata | 1989 |
Cultured cerebellar cells as an in vitro model of excitatory amino acid receptor function.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Cyclic GMP; Kainic Acid; Models, Neurological; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1987 |
Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.
Topics: Animals; Aspartic Acid; Enkephalins; Hot Temperature; Kainic Acid; Male; Mice; N-Methylaspartate; Narcotics; Nociceptors; Oxadiazoles; Pain; Phencyclidine; Phentolamine; Quisqualic Acid; Receptors, Opioid; Receptors, sigma; Spinal Cord | 1987 |
Functional and biochemical characteristics of a putative quisqualate-type receptor in rat striatum: effect of brain lesions.
Topics: Animals; Aspartic Acid; Brain; Cerebral Cortex; Convulsants; Corpus Striatum; Dopamine; Glutamates; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Potassium; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Drug | 1986 |
New quinoxalinediones show potent antagonism of quisqualate responses in cultured mouse cortical neurons.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Kainic Acid; Mice; N-Methylaspartate; Oxadiazoles; Quinoxalines; Quisqualic Acid; Receptors, AMPA; Receptors, Drug; Sodium | 1988 |
The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro.
Topics: Animals; Aspartic Acid; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Interactions; Electrophysiology; Kainic Acid; N-Methylaspartate; Osmolar Concentration; Phencyclidine; Receptors, Amino Acid; Receptors, Cell Surface | 1988 |
Release of [3H]norepinephrine from rat hippocampal slices by N-methyl-D-aspartate: comparison of the inhibitory effects of Mg2+ and MK-801.
Topics: Amino Acids; Animals; Aspartic Acid; Convulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; In Vitro Techniques; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1988 |
Excitatory amino acids: role in morphine excitation in rat periaqueductal gray.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Kainic Acid; Male; Morphine; Motor Activity; N-Methylaspartate; Oxadiazoles; Periaqueductal Gray; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
The NMDA receptor: central role in pain inhibition in rat periaqueductal gray.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Analgesia; Animals; Aspartic Acid; Kainic Acid; Male; Morphine; N-Methylaspartate; Oxadiazoles; Pain; Periaqueductal Gray; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
The involvement of excitatory amino acid receptors within the prepiriform cortex in pilocarpine-induced limbic seizures in rats.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Kainic Acid; Male; N-Methylaspartate; Olfactory Bulb; Oxadiazoles; Pilocarpine; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reference Values; Seizures | 1988 |
Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo.
Topics: Animals; Aspartic Acid; Brain; Calpain; Cytosol; Enzyme Activation; Erythrocytes; Humans; Isoenzymes; Kainic Acid; Male; N-Methylaspartate; Nerve Tissue Proteins; Peptide Mapping; Rats; Rats, Inbred Strains; Spectrin; Substrate Specificity | 1988 |
Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Corpus Callosum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Ketamine; Male; Muscimol; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Potassium; Quisqualic Acid; Rats; Rats, Inbred Strains; Tetrodotoxin | 1985 |
Roles of aspartate and glutamate in synaptic transmission in rabbit retina. I. Outer plexiform layer.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Neurotransmitter Agents; Rabbits; Retina; Synaptic Transmission | 1985 |
Excitatory effects of L-glutamate and some analogs on isolated horizontal cells from the catfish retina.
Topics: Animals; Aspartic Acid; Fishes; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Retina | 1985 |
Anticonvulsant action of beta-kainic acid in mice. Is beta-kainic acid an N-methyl-D-aspartate antagonist?
Topics: Animals; Anticonvulsants; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Homocysteine; Kainic Acid; Mice; N-Methylaspartate; Oxadiazoles; Pyrrolidines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Seizures; Stereoisomerism | 1985 |
Effects of excitatory amino acids on calcium transport by brain membranes.
Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport, Active; Brain Chemistry; Calcium; Glutamates; Glutamic Acid; Kainic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Neurotransmitter Agents; Synaptosomes | 1985 |
Calcium influx accompanies but does not cause excitotoxin-induced neuronal necrosis in retina.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Aspartic Acid; Calcium; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Mice; N-Methylaspartate; Necrosis; Nicotinic Acids; Nimodipine; Pyrrolidines; Retina | 1985 |
Anticonvulsant properties of 3-hydroxy-2-quinoxalinecarboxylic acid, a newly found antagonist of excitatory amino acids.
Topics: Animals; Anticonvulsants; Aspartic Acid; Electroencephalography; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Picrotoxin; Pyrrolidines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Structure-Activity Relationship | 1985 |
L-[3H]Glutamate binds to kainate-, NMDA- and AMPA-sensitive binding sites: an autoradiographic analysis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Binding Sites; Brain; Brain Chemistry; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1985 |
Effects of bath-applied excitatory amino acids and their analogs on spinal interneurons of the lamprey.
Topics: Amino Acids; Animals; Aspartic Acid; Fishes; Glutamates; Glutamic Acid; Glycine; Homocysteine; In Vitro Techniques; Interneurons; Kainic Acid; Lampreys; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Spinal Cord | 1985 |
L-Homocysteic acid as an alternative cytotoxin for studying glutamate-induced cellular degeneration of Huntington's disease and normal skin fibroblasts.
Topics: Aspartic Acid; Cell Survival; Cells, Cultured; Cysteic Acid; Cysteine; Fibroblasts; Glutamates; Glutamic Acid; Homocysteine; Humans; Huntington Disease; In Vitro Techniques; Isomerism; Kainic Acid; Kinetics; N-Methylaspartate; Neurotransmitter Agents; Skin; Time Factors | 1985 |
Peptides derived from kainic acid as antagonists of N-methyl-D-aspartate-induced neuroexcitation in rat brain.
Topics: Animals; Aspartic Acid; Corpus Striatum; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats | 1985 |
Excitatory and inhibitory responses of Purkinje cells, in the rat cerebellum in vivo, induced by excitatory amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Neurochemical relation between excitatory and inhibitory amino acids in hippocampus.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Cysteine; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurons; Neurotransmitter Agents; Oxadiazoles; Potassium; Quisqualic Acid; Rats; Rats, Inbred Strains | 1985 |
A dipeptide derived from kainic and L-glutamic acids: a selective antagonist of amino acid induced neuroexcitation with anticonvulsant properties.
Topics: Animals; Aspartic Acid; Cell Membrane Permeability; Corpus Striatum; Dipeptides; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Oxadiazoles; Picrotoxin; Quisqualic Acid; Rats; Seizures; Sodium | 1985 |
Ketamine acts as a non-competitive N-methyl-D-aspartate antagonist on frog spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Kainic Acid; Ketamine; Magnesium; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rana pipiens; Rana temporaria; Spinal Cord; Valine | 1985 |
The role of putative excitatory amino acid neurotransmitters in the initiation of locomotion in the lamprey spinal cord. II. The effects of amino acid uptake inhibitors.
Topics: Amino Acids; Animals; Aspartic Acid; Fishes; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Lampreys; Locomotion; N-Methylaspartate; Neurotransmitter Agents; Spinal Cord; Synaptic Transmission | 1985 |
Kynurenic acid and quinolinic acid act at N-methyl-D-aspartate receptors in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1986 |
Evidence for an excitatory amino acid as the transmitter of the auditory nerve in the in vitro mouse cochlear nucleus.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cochlear Nerve; Dose-Response Relationship, Drug; Evoked Potentials; Female; Kainic Acid; Male; Mice; Mice, Inbred C3H; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Pipecolic Acids; Quisqualic Acid; Receptors, Neurotransmitter; Valine; Vestibulocochlear Nerve | 1985 |
Excitatory amino acid analogs evoke release of endogenous amino acids and acetyl choline from chick retina in vitro.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Calcium; Chickens; Dose-Response Relationship, Drug; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Potassium; Quisqualic Acid; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Sodium; Stimulation, Chemical | 1985 |
Induction of glutamate binding sites in hippocampal membranes by transient exposure to high concentrations of glutamate or glutamate analogs.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Aminobutyrates; Animals; Aspartic Acid; Binding Sites; Chlorides; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Kinetics; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Saponins; Sodium; Valine | 1986 |
Effects of topically applied excitatory amino acids on evoked potentials and single cell activity in rat cerebral cortex.
Topics: Administration, Topical; Amino Acids; Animals; Aspartic Acid; Carbachol; Cerebral Cortex; Evoked Potentials, Somatosensory; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tetrodotoxin | 1986 |
Activity of beta-kainic acid on neocortical neurons in vivo and hippocampal neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dipeptides; Dose-Response Relationship, Drug; Evoked Potentials, Somatosensory; Hippocampus; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; Rats; Receptors, Neurotransmitter; Valine | 1986 |
N-methyl D-aspartate acts as an antagonist of the photoreceptor transmitter in the carp retina.
Topics: Animals; Aspartic Acid; Carps; Glutamates; Glutamic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neural Inhibition; Neurotransmitter Agents; Photic Stimulation; Photoreceptor Cells; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina | 1986 |
Pharmacologically distinct glutamate receptors on cerebellar granule cells.
Topics: 2-Aminoadipic Acid; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Isomerism; Kainic Acid; Kinetics; Mice; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1986 |
Role of excitatory amino acid transmission in the genesis of seizures elicited from the deep prepiriform cortex.
Topics: Animals; Aspartic Acid; Bicuculline; Carbachol; Glutamates; Glutamic Acid; Kainic Acid; Limbic System; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Seizures | 1986 |
Comparative actions of quisqualate and N-methyl-D-aspartate, excitatory amino acid agonists, on guinea-pig cochlear potentials.
Topics: Action Potentials; Animals; Aspartic Acid; Cochlea; Dose-Response Relationship, Drug; Evoked Potentials; Glutamates; Glutamic Acid; Guinea Pigs; Kainic Acid; Kinetics; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Vestibulocochlear Nerve | 1986 |
Characterization of the inhibition of excitatory amino acid-induced neurotransmitter release in the rat striatum by phencyclidine-like drugs.
Topics: Animals; Aspartic Acid; Corpus Striatum; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Kainic Acid; Magnesium; Male; N-Methylaspartate; Neurotransmitter Agents; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1986 |
Neurons containing NADPH-diaphorase are selectively resistant to quinolinate toxicity.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Humans; Huntington Disease; Kainic Acid; Mice; N-Methylaspartate; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; Neurons; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid | 1986 |
Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Autoradiography; Female; Glutamates; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Male; Middle Aged; N-Methylaspartate; Neuronal Plasticity; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission | 1986 |
Cellular origins of cyclic GMP responses to excitatory amino acid receptor agonists in rat cerebellum in vitro.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Drug Interactions; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Nitroprusside; Purkinje Cells; Rats; Tetrodotoxin | 1987 |
Magnesium ions inhibit the stimulation of inositol phospholipid hydrolysis by endogenous excitatory amino acids in primary cultures of cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Drug Synergism; Glutamates; Glutamic Acid; Hydrolysis; Inositol Phosphates; Kainic Acid; Magnesium; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Sugar Phosphates; Valine; Veratridine | 1987 |
Phencyclidine selectively inhibits N-methyl-D-aspartate-induced hippocampal [3H]norepinephrine release.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Structure-Activity Relationship; Valine | 1987 |
Excitatory amino acids and intracellular pH in motoneurons of the isolated frog spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anterior Horn Cells; Anura; Aspartic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Kainic Acid; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Valine | 1986 |
Excitatory amino acid receptors and ischemic brain damage in the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Hippocampus; Ibotenic Acid; Ischemic Attack, Transient; Kainic Acid; N-Methylaspartate; Rats; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Neurotransmitter; Time Factors | 1987 |
Biphasic effect of quinolinate on frog spinal, but not rat cortical, neurones: N-methyl-D-aspartate-like depolarisation and a novel type of hyperpolarisation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anterior Horn Cells; Anura; Aspartic Acid; Drug Interactions; Gyrus Cinguli; Kainic Acid; Ketamine; Magnesium; Membrane Potentials; Motor Neurons; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Valine | 1987 |
Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cell Membrane; Cerebral Cortex; Drug Interactions; Electrophysiology; Homocysteine; Ibotenic Acid; Kainic Acid; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Oxadiazoles; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Zinc | 1987 |
The effects of prolonged superfusions with acidic amino acids and their agonists on field potentials and horizontal cell photoresponses in the turtle retina.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; Membrane Potentials; N-Methylaspartate; Perfusion; Photoreceptor Cells; Retina; Turtles | 1987 |
Respiratory and vasomotor effects of excitatory amino acid on ventral medullary surface.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apnea; Aspartic Acid; Blood Pressure; Carotid Sinus; Cats; Female; Glutamates; Kainic Acid; Male; Medulla Oblongata; N-Methylaspartate; Oxadiazoles; Phrenic Nerve; Quisqualic Acid; Respiration; Vagotomy; Valine; Vasomotor System | 1987 |
Excitatory amino acid receptor potency and subclass specificity of sulfur-containing amino acids.
Topics: Amino Acids, Sulfur; Aminobutyrates; Animals; Aspartic Acid; Brain; Chick Embryo; Glutamates; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Sodium; Synaptic Membranes | 1987 |
Excitatory amino acid-induced release of 3H-GABA from cultured mouse cerebral cortex interneurons.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Binding Sites; Cerebral Cortex; gamma-Aminobutyric Acid; Kainic Acid; Mice; N-Methylaspartate; Neurons; Oxadiazoles; Potassium; Quisqualic Acid; Valine | 1987 |
AMPA is a powerful neurotoxin in the chicken retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Chickens; Choline O-Acetyltransferase; Dose-Response Relationship, Drug; Ibotenic Acid; Injections; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Oxadiazoles; Oxazoles; Quisqualic Acid; Retina; Retinal Ganglion Cells; Vitreous Body | 1987 |
[3H]norepinephrine release from hippocampal slices is an in vitro biochemical tool for investigating the pharmacological properties of excitatory amino acid receptors.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Glutamates; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Tetrodotoxin | 1987 |
The mouse neocortical slice: preparation and responses to excitatory amino acids.
Topics: Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Bicuculline; Cerebral Cortex; Corpus Callosum; In Vitro Techniques; Kainic Acid; Male; Membrane Potentials; Mice; Mice, Inbred Strains; N-Methylaspartate; Ouabain; Oxadiazoles; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Tetrodotoxin | 1987 |
Autoradiographic localization of cerebellar excitatory amino acid binding sites in the mouse.
Topics: Animals; Aspartic Acid; Autoradiography; Binding Sites; Cerebellum; Glutamates; Glutamic Acid; Kainic Acid; Mice; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface | 1987 |
Peripheral type benzodiazepine binding sites are a sensitive indirect index of neuronal damage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding Sites; Choline O-Acetyltransferase; Corpus Striatum; Glutamate Decarboxylase; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
Lesions of putative glutamatergic pathways potentiate the increase of inositol phospholipid hydrolysis elicited by excitatory amino acids.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Colchicine; Corpus Striatum; Glutamates; Glutamic Acid; Hippocampus; Hydrolysis; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1987 |
L-homocysteic acid: an endogenous excitotoxic ligand of the NMDA receptor.
Topics: Animals; Aspartic Acid; Binding, Competitive; Brain; Chick Embryo; Glutamates; Glutamic Acid; Homocysteine; Kainic Acid; Ligands; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina | 1987 |
Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Isomerism; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Oxadiazoles; Quisqualic Acid; Valine | 1988 |
Excitatory amino acid-evoked membrane currents and excitatory synaptic transmission in lamprey reticulospinal neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Stem; Electric Stimulation; Evoked Potentials; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Lampreys; N-Methylaspartate; Neurons; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Spinal Cord; Synapses; Synaptic Transmission | 1988 |
Utilization of the synthetic phosphagen cyclocreatine phosphate by a simple brain model during stimulation by neuroexcitatory amino acids.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Chick Embryo; Glutamates; Glutamic Acid; Homocysteine; Imidazolidines; Kainic Acid; Magnesium; N-Methylaspartate; Phosphocreatine | 1988 |
Enhancement of the oxygen consumption in the hippocampal slices of the guinea pig induced by glutamate and its related substances.
Topics: Action Potentials; Animals; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Oxygen Consumption | 1988 |
An excitatory amino acid projection from ventromedial hypothalamus to periaqueductal gray in the rat: autoradiographic and electrophysiological evidence.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Autoradiography; Electric Stimulation; Kainic Acid; Male; N-Methylaspartate; Neural Pathways; Periaqueductal Gray; Rats; Rats, Inbred Strains; Reaction Time; Valine; Ventromedial Hypothalamic Nucleus | 1988 |
NMDA- and kainate-evoked GABA release from striatal neurones differentiated in primary culture: differential blocking by phencyclidine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Corpus Striatum; gamma-Aminobutyric Acid; Kainic Acid; Mice; N-Methylaspartate; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Quinolinic acid effects on amino acid release from the rat cerebral cortex in vitro and in vivo.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Valine | 1988 |
Differential control by N-methyl-D-aspartate and kainate of striatal dopamine release in vivo: a trans-striatal dialysis study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Atropine; Carbachol; Corpus Striatum; Dopamine; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Tetrodotoxin; Valine | 1988 |
L-glutamate-induced depolarization in solitary photoreceptors: a process that may contribute to the interaction between photoreceptors in situ.
Topics: Animals; Aspartic Acid; Axons; Dose-Response Relationship, Drug; Electric Conductivity; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Photoreceptor Cells; Quisqualic Acid; Sodium; Turtles | 1988 |
Amino acids modulate calcium permeability of the plasma membrane of human neuroblastoma cells.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aspartic Acid; Calcium; Cell Membrane Permeability; Cysteine; Humans; Kainic Acid; N-Methylaspartate; Neuroblastoma; Neurotransmitter Agents; Tumor Cells, Cultured; Valine | 1988 |
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding, Competitive; Cell Membrane; Cerebral Cortex; Ibotenic Acid; Kainic Acid; Ketamine; N-Methylaspartate; Neurons; Piperazines; Quinoxalines; Rats; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1988 |
Effects of excitatory amino acids on the oxygen consumption of hippocampal slices from the guinea pig.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Glutamates; Guinea Pigs; Hippocampus; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Oxadiazoles; Oxygen Consumption; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Spider Venoms; Valine | 1988 |
Excitatory amino acid receptors expressed in Xenopus oocytes: agonist pharmacology.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Chlorides; Female; Ibotenic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Drug; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine; Xenopus | 1988 |
Glutamate stimulates somatostatin release from diencephalic neurons in primary culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Diencephalon; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Oxadiazoles; Phencyclidine; Potassium; Quisqualic Acid; Rats; Somatostatin; Tetrodotoxin; Valine; Veratridine | 1988 |
Kynurenate and FG9041 have both competitive and non-competitive antagonist actions at excitatory amino acid receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1988 |
Role of quisqualic acid receptors in the hypermotility response produced by the injection of AMPA into the nucleus accumbens.
Topics: 2-Aminoadipic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Glutamates; Glutamine; Ibotenic Acid; Injections; Kainic Acid; Locomotion; Male; N-Methylaspartate; Nucleus Accumbens; Oxadiazoles; Oxazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Drug | 1988 |
Epileptiform bursts elicited in CA3 hippocampal neurons by a variety of convulsants are not blocked by N-methyl-D-aspartate antagonists.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Hippocampus; In Vitro Techniques; Kainic Acid; Kindling, Neurologic; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Behavioral classification of excitatory amino acid receptors in mouse spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Behavior, Animal; Glutamates; Glutamic Acid; Glutamine; Kainic Acid; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord; Valine | 1988 |
Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Ibotenic Acid; Isoflurane; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Piperazines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Time Factors | 1988 |
Epinephrine and norepinephrine modulate neuronal responses to excitatory amino acids and agonists in frog spinal cord.
Topics: Amino Acids; Animals; Aspartic Acid; Epinephrine; Glutamates; Glutamic Acid; In Vitro Techniques; Isoproterenol; Kainic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Norepinephrine; Oxadiazoles; Quisqualic Acid; Rana pipiens; Reference Values; Spinal Cord; Yohimbine | 1987 |
Properties of two classes of rat brain acidic amino acid receptors induced by distinct mRNA populations in Xenopus oocytes.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Glycine; Kainic Acid; N-Methylaspartate; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; RNA, Messenger; Xenopus laevis | 1988 |
Quisqualate, kainate and NMDA can initiate spreading depression in the turtle cerebellum.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Cerebellum; Electric Stimulation; In Vitro Techniques; Kainic Acid; Magnesium; N-Methylaspartate; Neural Inhibition; Oxadiazoles; Quisqualic Acid; Turtles; Valine | 1988 |
Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by N-methyl-D-aspartate receptor activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Chlorides; Glutamates; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Lithium; Lithium Chloride; N-Methylaspartate; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1988 |
Effect of GABAergic transmission in the subpallidal region on the hypermotility response to the administration of excitatory amino acids and picrotoxin into the nucleus accumbens.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamine; Animals; Aspartic Acid; Basal Ganglia; Brain; gamma-Aminobutyric Acid; Ibotenic Acid; Kainic Acid; Male; Motor Activity; Muscimol; N-Methylaspartate; Nucleus Accumbens; Picrotoxin; Rats; Rats, Inbred Strains; Septal Nuclei; Substantia Innominata; Synaptic Transmission | 1988 |
Glutamate receptors of ganglion cells in the rabbit retina: evidence for glutamate as a bipolar cell transmitter.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamates; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Light; Membrane Potentials; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Rabbits; Receptors, Glutamate; Receptors, Neurotransmitter; Retina; Retinal Ganglion Cells | 1988 |
Acute tachycardia and pressor effects following injections of kainic acid into the antero-dorsal medial hypothalamus.
Topics: Animals; Aspartic Acid; Blood Pressure; Heart Rate; Hypothalamus; Injections; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Rats, Inbred Strains | 1987 |
The action of quinolinate in the rat spinal cord in vitro.
Topics: Animals; Anticonvulsants; Aspartic Acid; Convulsants; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Rats, Inbred Strains; Spinal Cord | 1987 |
Excitatory amino acid pharmacology of the auditory nerve and nucleus magnocellularis of the chicken.
Topics: Amino Acids; Animals; Aspartic Acid; Auditory Pathways; Baclofen; Brain Stem; Chick Embryo; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Neurotransmitter; Vestibulocochlear Nerve | 1985 |
Anticonvulsant action of stereoisomers of gamma-glutamylaminomethylsulphonic acid in mice.
Topics: Animals; Anticonvulsants; Aspartic Acid; Glutamates; Glutamine; Kainic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship | 1985 |
Novel kainic acid analogues. Effects on cyclic GMP content of adult rat cerebellar slices.
Topics: Animals; Aspartic Acid; Calcium; Cerebellum; Cyclic GMP; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Neurotransmitter; Structure-Activity Relationship | 1986 |
In vitro neurotoxicity of excitatory acid analogues during cerebellar development.
Topics: Aging; Animals; Aspartic Acid; Cerebellum; Female; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurotoxins; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Tetrodotoxin | 1986 |
Is Metaphit a phencyclidine antagonist? Studies with ketamine, phencyclidine and N-methylaspartate.
Topics: Action Potentials; Animals; Aspartic Acid; Depression, Chemical; Drug Interactions; Kainic Acid; Ketamine; N-Methylaspartate; Neurons; Oxadiazoles; Phencyclidine; Quisqualic Acid; Rats; Receptors, Opioid; Receptors, sigma; Spinal Cord | 1986 |
Neurotoxicity of excitatory amino acid receptor agonists in rat cerebellar slices: dependence on calcium concentration.
Topics: Animals; Aspartic Acid; Calcium; Cerebellum; Golgi Apparatus; Granulocytes; Kainic Acid; N-Methylaspartate; Necrosis; Neurons; Osmolar Concentration; Rats; Receptors, Amino Acid; Receptors, Cell Surface | 1986 |
An animal model for neuron-specific spinal cord lesions by the microinjection of N-methylaspartate, kainic acid, and quisqualic acid.
Topics: Animals; Aspartic Acid; Disease Models, Animal; Forelimb; Ganglia, Spinal; Hindlimb; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Synaptic Transmission | 1985 |
Excitatory amino acid antagonists as novel anticonvulsants.
Topics: Amino Acids, Dicarboxylic; Animals; Anticonvulsants; Aspartic Acid; Epilepsy; Glutamates; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Nervous System Diseases; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Structure-Activity Relationship | 1986 |
Muscle relaxant and anticonvulsant activity of 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid, a novel N-methyl-D-aspartate antagonist, in rodents.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Kainic Acid; Mice; Muscle Relaxants, Central; N-Methylaspartate; Oxadiazoles; Piperazines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reflex; Time Factors | 1987 |
After-hyperpolarizations produced in frog motoneurons by excitatory amino acid analogues.
Topics: 2,4-Dinitrophenol; Animals; Aspartic Acid; Dinitrophenols; Kainic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Ouabain; Oxadiazoles; Potassium; Quisqualic Acid; Ranidae; Sodium; Synaptic Transmission | 1987 |
Evidence that antagonism at non-NMDA receptors results in anticonvulsant action.
Topics: Animals; Anticonvulsants; Aspartic Acid; Glutamates; Glutamine; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Piperazines; Receptors, Amino Acid; Receptors, Cell Surface | 1987 |
A comparison of excitatory amino acid antagonists acting at primary afferent C fibres and motoneurones of the isolated spinal cord of the rat.
Topics: Amino Acids; Animals; Aspartic Acid; In Vitro Techniques; Kainic Acid; Motor Neurons; N-Methylaspartate; Nerve Fibers; Neurons, Afferent; Oxadiazoles; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1987 |
Dextrorphan and levorphanol selectively block N-methyl-D-aspartate receptor-mediated neurotoxicity on cortical neurons.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Dextrorphan; Kainic Acid; Levorphanol; Mice; Morphinans; N-Methylaspartate; Neurons; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Excitatory amino acid neurotoxicity in the hippocampal slice preparation.
Topics: Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Hippocampus; Ibotenic Acid; Kainic Acid; Male; Microscopy, Electron; N-Methylaspartate; Neurotoxins; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains | 1988 |
Excitatory amino acids and rod photoreceptor disc shedding: analysis using specific agonists.
Topics: Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; In Vitro Techniques; Kainic Acid; Light; N-Methylaspartate; Oxadiazoles; Phagosomes; Photoreceptor Cells; Pigment Epithelium of Eye; Quisqualic Acid; Rana pipiens; Xenopus laevis | 1988 |
Piriform cortex brain slices: techniques for isolation of synaptic inputs.
Topics: Aminobutyrates; Animals; Aspartic Acid; Cerebral Cortex; Dendrites; Electrophysiology; Evoked Potentials; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Synapses | 1988 |
Regulation of seizure threshold by excitatory amino acids in the striatum and entopeduncular nucleus of rats.
Topics: Animals; Aspartic Acid; Corpus Striatum; Globus Pallidus; Kainic Acid; Male; N-Methylaspartate; Pilocarpine; Rats; Rats, Inbred Strains; Seizures | 1988 |
A voltage clamp study of the glutamate responsive neuromuscular junction in Drosophila melanogaster.
Topics: Action Potentials; Alcohols; Amino Acids; Animals; Aspartic Acid; Drosophila melanogaster; Electrodes; Glutamates; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neuromuscular Junction; Oxadiazoles; Quisqualic Acid | 1988 |
Putative serotonergic bipolar and amacrine cells in the chicken retina.
Topics: 5,7-Dihydroxytryptamine; Animals; Aspartic Acid; Chickens; Fluorescent Antibody Technique; Kainic Acid; N-Methylaspartate; Neurotoxins; Retina; Serotonin | 1988 |
Some properties of membrane current fluctuations induced by kainate, quisqualate, and NMDA in cultured septal neurons of rat.
Topics: Animals; Aspartic Acid; Brain; Cells, Cultured; Convulsants; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats | 1988 |
Behavioural, biochemical and histochemical effects of different neurotoxic amino acids injected into nucleus basalis magnocellularis of rats.
Topics: Acetylcholinesterase; Amino Acids; Animals; Aspartic Acid; Basal Ganglia; Behavior, Animal; Cerebral Cortex; Choline O-Acetyltransferase; Cholinergic Fibers; Female; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Substantia Innominata | 1987 |
Systemic administration of MK-801 prevents N-methyl-D-aspartate-induced neuronal degeneration in rat brain.
Topics: Animals; Aspartic Acid; Choline O-Acetyltransferase; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Rats; Rats, Inbred Strains | 1987 |
Responses of pyriform cortex neurons to excitatory amino acids: voltage dependence, conductance changes, and effects of divalent cations.
Topics: Animals; Aspartic Acid; Brain; Cations, Divalent; Convulsants; Electric Stimulation; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurons; Oxadiazoles; Pyramidal Tracts; Quisqualic Acid; Rats | 1987 |
Folic acid protects chick retinal neurons against the neurotoxic action of excitatory amino acids.
Topics: Animals; Aspartic Acid; Chickens; Dose-Response Relationship, Drug; Folic Acid; Kainic Acid; Microscopy, Electron; N-Methylaspartate; Neurons; Oxadiazoles; Quinolinic Acids; Quisqualic Acid; Retina | 1987 |
Effects of L-cysteine-sulphinate and L-aspartate, mixed excitatory amino acid agonists, on the membrane potential of cat caudate neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cats; Caudate Nucleus; Cysteine; Female; Kainic Acid; Male; Membrane Potentials; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid | 1987 |
Non-pharmacological effects of the use of microelectrophoresis and pressure ejection of drugs in combination.
Topics: Amino Acids; Animals; Aspartic Acid; Electrophoresis; Ibotenic Acid; Kainic Acid; Microelectrodes; N-Methylaspartate; Neurons; Nifedipine; Oxadiazoles; Quisqualic Acid; Rats; Spinal Cord | 1987 |
MK-801 powerfully protects against N-methyl aspartate neurotoxicity.
Topics: Animals; Anticonvulsants; Aspartic Acid; Autoradiography; Binding, Competitive; Chick Embryo; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Kainic Acid; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains | 1987 |
Selective loss of Purkinje and granule cell responsiveness to N-methyl-D-aspartate in rat cerebellum during development.
Topics: Aging; Animals; Aspartic Acid; Cerebellum; Convulsants; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats | 1987 |
The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cells, Cultured; Corpus Striatum; Glutamates; In Vitro Techniques; Kainic Acid; Magnesium; Mice; N-Methylaspartate; Neurons; Oxadiazoles; Permeability; Quisqualic Acid | 1987 |
2-Methyl-3,3-diphenyl-3-propanolamine (2-MDP) selectively antagonises N-methyl-aspartate (NMA).
Topics: Anesthetics; Anesthetics, Dissociative; Animals; Anura; Aspartic Acid; In Vitro Techniques; Kainic Acid; Ketamine; Medulla Oblongata; N-Methylaspartate; Neurons; Oxadiazoles; Phenylpropanolamine; Quisqualic Acid; Rats; Spinal Cord | 1986 |
The primary afferent depolarizing action of kainate in the rat.
Topics: Action Potentials; Afferent Pathways; Animals; Aspartic Acid; Capsaicin; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Nerve Fibers; Oxadiazoles; Quisqualic Acid; Rats; Spinal Nerve Roots | 1986 |
The anti-excitotoxic effects of certain anesthetics, analgesics and sedative-hypnotics.
Topics: Analgesics; Anesthetics; Animals; Aspartic Acid; Chick Embryo; Hypnotics and Sedatives; Kainic Acid; N-Methylaspartate; Neurotoxins; Retina | 1986 |
Reversible and irreversible neuronal damage caused by excitatory amino acid analogues in rat cerebellar slices.
Topics: Animals; Aspartic Acid; Cerebellar Cortex; Cerebellar Diseases; Cerebellar Nuclei; Female; In Vitro Techniques; Kainic Acid; Male; Microscopy, Electron; N-Methylaspartate; Purkinje Cells; Rats; Rats, Inbred Strains | 1986 |
Ionic requirements for neurotoxic effects of excitatory amino acid analogues in rat cerebellar slices.
Topics: Animals; Aspartic Acid; Calcium; Cerebellar Diseases; Cerebellum; Chlorides; Female; In Vitro Techniques; Kainic Acid; Male; Microscopy, Electron; N-Methylaspartate; Rats; Rats, Inbred Strains; Sodium | 1986 |
Amino acid neurotoxicity: relationship to neuronal depolarization in rat cerebellar slices.
Topics: Age Factors; Animals; Aspartic Acid; Cerebellar Diseases; Female; In Vitro Techniques; Kainic Acid; Male; Membrane Potentials; N-Methylaspartate; Ouabain; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Rats, Inbred Strains; Veratridine | 1986 |
O-phosphohomoserine, a naturally occurring analogue of phosphonate amino acid antagonists, is an N-methyl-D-aspartate (NMDA) antagonist in rat hippocampus.
Topics: Animals; Aspartic Acid; Drug Interactions; Evoked Potentials; Hippocampus; Homoserine; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats | 1986 |
Alterations in extracellular amino acids and Ca2+ following excitotoxin administration and during status epilepticus.
Topics: Amino Acids; Animals; Aspartic Acid; Bicuculline; Calcium; Epilepsy; Ethanolamines; Extracellular Space; Glutamates; Hippocampus; Kainic Acid; N-Methylaspartate; Rabbits; Synaptic Membranes; Synaptosomes; Taurine; Tetrodotoxin | 1986 |
Long-term alterations in amino acid-induced ionic conductances in chronic epilepsy.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cobalt; Electric Conductivity; Epilepsy; Glutamates; Kainic Acid; Motor Cortex; N-Methylaspartate; Oxadiazoles; Pyramidal Tracts; Quisqualic Acid; Rats; Sodium | 1986 |
Excitatory amino acids and epilepsy-induced changes in extracellular space size.
Topics: Animals; Aspartic Acid; Cats; Epilepsy; Extracellular Space; Hippocampus; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neuroglia; Oxadiazoles; Potassium; Quisqualic Acid; Somatosensory Cortex; Water-Electrolyte Balance | 1986 |
Effects of kainate on CA1 hippocampal neurons recorded in vitro.
Topics: Action Potentials; Animals; Aspartic Acid; Calcium; Electric Conductivity; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Potassium | 1986 |
A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Diazepam; Electroencephalography; Hippocampus; Injections; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1986 |
Unusual interactions of excitatory amino acid receptor agonists: alpha- and beta-kainate antagonize motor responses to N-methyl-D-aspartate in rodents.
Topics: Animals; Aspartic Acid; Electromyography; Kainic Acid; Male; Mice; Motor Activity; Muscle Spasticity; Muscle Tonus; N-Methylaspartate; Seizures; Stereoisomerism | 1987 |
Dopamine inhibits calcium-independent gamma-[3H]aminobutyric acid release induced by kainate and high K+ in the fish retina.
Topics: Animals; Aspartic Acid; Bicuculline; Calcium; Dopamine; Fishes; gamma-Aminobutyric Acid; Haloperidol; Kainic Acid; N-Methylaspartate; Oxadiazoles; Picrotoxin; Potassium; Pyrrolidines; Quisqualic Acid; Retina; Serotonin | 1985 |
Anticonvulsant activity of two novel piperazine derivatives with potent kainate antagonist activity.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Aspartic Acid; Chemical Phenomena; Chemistry; Glutamates; Kainic Acid; Mice; Mice, Inbred DBA; Mice, Inbred Strains; N-Methylaspartate; Oxadiazoles; Piperazines; Pyrrolidines; Quinolinic Acids; Quisqualic Acid; Seizures | 1985 |
Effect of ketamine on amino acid-evoked release of acetylcholine from rat cerebral cortex in vitro.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Cerebral Cortex; Dose-Response Relationship, Drug; In Vitro Techniques; Kainic Acid; Ketamine; Magnesium; N-Methylaspartate; Potassium Chloride; Rats | 1985 |
Degeneration of cholinergic neurons in the basal nucleus following kainic or N-methyl-D-aspartic acid application to the cerebral cortex in the rat.
Topics: Animals; Aspartic Acid; Basal Ganglia; Cerebral Cortex; Cholinergic Fibers; Kainic Acid; N-Methylaspartate; Neural Pathways; Pyrrolidines; Rats; Rats, Inbred Strains; Substantia Innominata | 1985 |
An intracellular study of the interactions of N-methyl-DL-aspartate with ketamine in the mouse hippocampal slice.
Topics: Action Potentials; Animals; Aspartic Acid; Drug Interactions; Hippocampus; In Vitro Techniques; Kainic Acid; Ketamine; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Oxadiazoles; Quisqualic Acid | 1985 |
Differences of neuronal sensitivity to amino acids and related compounds in the rat hippocampal slice.
Topics: Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Evoked Potentials; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Neurons; Quinolinic Acids; Rats; Rats, Inbred Strains | 1985 |
Separation of the motor consequences from other actions of unilateral 6-hydroxydopamine lesions in the nigrostriatal neurones of rat brain.
Topics: Animals; Aspartic Acid; Conditioning, Operant; Corpus Striatum; Functional Laterality; Hydroxydopamines; Injections, Intraventricular; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Nerve Crush; Neural Pathways; Neurons; Neurotoxins; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
The neurotoxicity of excitatory amino acids is produced by passive chloride influx.
Topics: Animals; Aspartic Acid; Calcimycin; Calcium; Cell Survival; Chlorides; Glutamates; Hippocampus; Kainic Acid; N-Methylaspartate; Neurons; Potassium; Pyrrolidines; Rodentia | 1985 |
Comparison of sigma- and kappa-opiate receptor ligands as excitatory amino acid antagonists.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Cats; Cyclazocine; Ethylketocyclazocine; Kainic Acid; Ketamine; Ligands; Microelectrodes; N-Methylaspartate; Neurons; Oxadiazoles; Phenazocine; Quisqualic Acid; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, sigma; Stereoisomerism | 1984 |
Electrophysiological studies on neuronal transmission in the frog's photosensory pineal organ. The effect of amino acids and biogenic amines.
Topics: 2-Aminoadipic Acid; Acetylcholine; Action Potentials; Amino Acids; Animals; Aspartic Acid; Biogenic Amines; Dose-Response Relationship, Drug; Glutamates; Kainic Acid; N-Methylaspartate; Neurons; Photic Stimulation; Photoreceptor Cells; Pineal Gland; Rana esculenta; Serotonin; Synaptic Transmission; Taurine | 1984 |
Pharmacological antagonists of excitant amino acid action.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aspartic Acid; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Receptors, Drug; Structure-Activity Relationship | 1981 |
Phosphonate analogues of carboxylic acids as aminoacid antagonists on rat cortical neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Drug Antagonism; Electric Conductivity; Glutamates; Glutamic Acid; Isomerism; Kainic Acid; N-Methylaspartate; Neurons; Organophosphorus Compounds; Rats; Valine | 1981 |
Stimulation of rat cerebellar guanosine 3',5'-cyclic monophosphate (cyclic GMP) levels: effects of amino acid antagonists.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cerebellum; Cyclic GMP; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; N-Methylaspartate; Protoveratrines; Rats; Rats, Inbred Strains | 1981 |
Specific and non-specific effects of neuro-excitatory amino acids on learning and other behaviours in the chicken.
Topics: Aggression; Aging; Animals; Aspartic Acid; Behavior, Animal; Chickens; Copulation; Glutamates; Glutamic Acid; Habituation, Psychophysiologic; Humans; Kainic Acid; Learning; N-Methylaspartate; Pattern Recognition, Visual; Pyrrolidines; Visual Perception | 1982 |
The action of six antagonists of the excitatory amino acids on neurones of the rat spinal cord.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Rats; Spinal Cord; Structure-Activity Relationship | 1982 |
Activity of the enantiomers of 2-amino-5-phosphono-valeric acid as stereospecific antagonists of excitatory aminoacids.
Topics: Adipates; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Dose-Response Relationship, Drug; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Rats; Stereoisomerism; Synaptic Transmission | 1981 |
Effect of urethane on synaptic and amino acid-induced excitation in isolated spinal cord preparations.
Topics: Animals; Aspartic Acid; Evoked Potentials; Ganglia, Spinal; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Ranidae; Rats; Spinal Cord; Synapses; Urethane | 1982 |
Excitatory amino acid receptors and guanosine 3',5'-cyclic monophosphate in incubated slices of immature and adult rat cerebellum.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Rats; Receptors, Amino Acid; Receptors, Cell Surface | 1982 |
Effects of D-alpha-aminoadipate on excitation of afferent fibers in the lateral line of Xenopus laevis.
Topics: 2-Aminoadipic Acid; Afferent Pathways; Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Female; Glutamates; Glutamic Acid; Hair Cells, Auditory; Kainic Acid; Male; Mechanoreceptors; Motor Activity; N-Methylaspartate; Synaptic Transmission; Xenopus laevis | 1982 |
Kainate, N-methylaspartate and other excitatory amino acids increase calcium influx into rat brain cortex cells in vitro.
Topics: Absorption; Amino Acids; Animals; Aspartic Acid; Calcium; Cerebral Cortex; Glutamates; Glutamic Acid; Homocysteine; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Rats | 1983 |
The antagonism of amino acid-induced excitations of rat hippocampal CA1 neurones in vitro.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Action Potentials; Amino Acids; Animals; Aspartic Acid; Dipeptides; Hippocampus; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Valine | 1983 |
The role of excitatory amino acid transmitters in the mudpuppy retina: an analysis with kainic acid and N-methyl aspartate.
Topics: Animals; Aspartic Acid; Glutamates; Kainic Acid; N-Methylaspartate; Necturus; Neurons; Neurotransmitter Agents; Photoreceptor Cells; Pyrrolidines; Receptors, Cell Surface; Retina; Retinal Ganglion Cells | 1983 |
Presence of N-methyl-D-aspartate-like and kainate-like activities in bovine brain.
Topics: Animals; Aspartic Acid; Brain Chemistry; Carbon Radioisotopes; Cattle; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Pyrrolidines | 1983 |
Blockade of amino acid-induced depolarizations and inhibition of excitatory post-synaptic potentials in rat dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Evoked Potentials; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Pipecolic Acids; Quisqualic Acid; Rats; Synapses; Valine | 1983 |
Effects of excitatory amino acids on locomotor activity after bilateral microinjection into the rat nucleus accumbens: possible dependence on dopaminergic mechanisms.
Topics: Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Nucleus Accumbens; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Seizures; Septal Nuclei; Synaptic Transmission | 1983 |
Effects of excitatory amino acids on dopamine synthesis in the rat retina.
Topics: Amino Acids; Animals; Aspartic Acid; Dopamine; Glutamates; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Retina | 1983 |
Effects of kainic and other amino acids on synaptic excitation in rat hippocampal slices: 1. Extracellular analysis.
Topics: Amino Acids; Animals; Aspartate Aminotransferases; Aspartic Acid; Evoked Potentials; Folic Acid; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neural Pathways; Oxadiazoles; Pyrrolidines; Quisqualic Acid; Rats | 1983 |
Effects of excitatory amino acids, and of their agonists and antagonists on the release of neurotransmitters from the chick retina.
Topics: Amino Acids; Animals; Aspartic Acid; Chickens; Cysteic Acid; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Endings; Neurotransmitter Agents; Receptors, Neurotransmitter; Retina; Synapses; Synaptic Transmission | 1983 |
Differential sensitivity of selected brain areas to excitatory amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Rats; Sodium; Stimulation, Chemical | 1983 |
On the sensitivity of H1 horizontal cells of the carp retina to glutamate, aspartate and their agonists.
Topics: Animals; Aspartic Acid; Carps; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Retina | 1984 |
The halomethylketone derivative L-Glu-gamma-DL-Ala-CH2Cl and N-methyl-D-aspartate as selective antagonists against L-glutamate and kainate excitation respectively on Retzius cells of the leech, Hirudo medicinalis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Ganglia; Kainic Acid; Leeches; Membrane Potentials; N-Methylaspartate; Pyrrolidines; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate | 1984 |
The effect of the dioxolanes on amino acid induced excitation in the mammalian spinal cord.
Topics: Animals; Aspartic Acid; Cats; Dioxolanes; Dioxoles; Kainic Acid; Ketamine; N-Methylaspartate; Oxadiazoles; Phencyclidine; Quisqualic Acid; Rats; Species Specificity; Spinal Cord; Stereoisomerism; Structure-Activity Relationship | 1984 |
Mixed-agonist action of excitatory amino acids on mouse spinal cord neurones under voltage clamp.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Culture Techniques; Electric Conductivity; Glutamates; Glutamic Acid; Homocysteine; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Spinal Cord; Valine | 1984 |
Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors.
Topics: 2-Aminoadipic Acid; Animals; Aspartic Acid; Calcium; Cerebellum; Corpus Striatum; Cyclic GMP; Glutamates; Hippocampus; Kainic Acid; Male; Mice; N-Methylaspartate; Pyrrolidines; Receptors, Cell Surface; Receptors, Glutamate; Receptors, Neurotransmitter | 1982 |
Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Kainic Acid; Male; Mice; N-Methylaspartate; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Seizures | 1982 |
Quisqualic acid excitation of cortical neurones is selectively antagonized by streptomycin.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Evoked Potentials; Kainic Acid; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Streptomycin; Synaptic Transmission | 1983 |
Excitatory amino acid receptors in Xenopus embryo spinal cord and their role in the activation of swimming.
Topics: Animals; Aspartic Acid; Kainic Acid; Manganese; Membrane Potentials; Motor Activity; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord; Swimming; Xenopus | 1984 |
Antagonism of the hypermotility response induced by excitatory amino acids in the rat nucleus accumbens.
Topics: 2-Aminoadipic Acid; Amino Acids; Animals; Aspartic Acid; Diaminopimelic Acid; Glutamates; Injections; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Nucleus Accumbens; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Septal Nuclei | 1984 |
Magnesium selectively inhibits N-methyl-aspartic acid-induced hypermotility after intra-accumbens injection.
Topics: Animals; Aspartic Acid; Calcium Chloride; Injections; Kainic Acid; Magnesium; Male; Motor Activity; N-Methylaspartate; Nucleus Accumbens; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains | 1984 |
Differential sensitivity of rat cerebellar cells in vitro to the neurotoxic effects of excitatory amino acid analogues.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebellum; In Vitro Techniques; Interneurons; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurotoxins; Oxadiazoles; Quisqualic Acid; Rats | 1984 |
The dissociation of evoked release of [3H]-GABA and of endogenous GABA from chick retina in vitro.
Topics: Animals; Aspartic Acid; Chickens; gamma-Aminobutyric Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Perfusion; Potassium Chloride; Retina; Tritium | 1984 |
Structure-activity relations of dipeptide antagonists of excitatory amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; Chemical Phenomena; Chemistry; Dipeptides; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rana pipiens; Rana temporaria; Spinal Cord; Structure-Activity Relationship | 1984 |
Isomers of 2-amino-7-phosphonoheptanoic acid as antagonists of neuronal excitants.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Hippocampus; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Rats | 1982 |
Acute motor effects of N-methyl-D-aspartic acid and kainic acid applied focally to mesencephalic dopamine cell body regions in the rat.
Topics: Animals; Aspartic Acid; Dopamine; Female; Fluphenazine; Kainic Acid; Mesencephalon; Motor Activity; N-Methylaspartate; Pyrrolidines; Rats; Rats, Inbred Strains; Substantia Nigra | 1980 |
Behavioural and biochemical studies in rats with N-methyl-D-aspartic acid and kainic acid [proceedings].
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain Chemistry; Kainic Acid; N-Methylaspartate; Pyrrolidines; Rats | 1980 |
Antagonism of excitatory amino acid-induced and synaptic excitation of spinal neurones by cis-2,3-piperidine dicarboxylate.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cats; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Pipecolic Acids; Quisqualic Acid; Rana temporaria; Rats; Spinal Cord; Synapses | 1981 |
Two conductance mechanisms activated by applications of L-glutamic, L-aspartic, DL-homocysteic, N-methyl-D-aspartic, and DL-kainic acids to cultured mammalian central neurones.
Topics: Animals; Aspartic Acid; Cells, Cultured; Central Nervous System; Female; Glutamates; Homocysteine; In Vitro Techniques; Kainic Acid; Magnesium; Mice; N-Methylaspartate; Neural Conduction; Neurons | 1980 |
N-Methyl-D-aspartate acid: a convulsant with weak neurotoxic properties.
Topics: Animals; Aspartic Acid; Convulsants; Corpus Striatum; Hippocampus; Kainic Acid; N-Methylaspartate; Neurotoxins; Rats | 1981 |
An evaluation of gamma-glutamyl dipeptide derivatives as antagonists of amino acid-induced Na+ fluxes in rat striatum slices.
Topics: Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Dipeptides; Glutamine; Kainic Acid; N-Methylaspartate; Rats; Sodium | 1982 |
Methyltetrahydrofolate as an antagonist of excitatory amino acids on spinal neurones.
Topics: Amino Acids; Animals; Aspartic Acid; Folic Acid; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Spinal Cord; Tetrahydrofolates | 1982 |
Interleukin-6 selectively enhances the intracellular calcium response to NMDA in developing CNS neurons.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; Extracellular Space; Interleukin-6; Intracellular Membranes; Kainic Acid; N-Methylaspartate; Neurons; Potassium; Rats; Rats, Sprague-Dawley; Signal Transduction | 1995 |
Hypoxia, excitotoxicity, and neuroprotection in the hippocampal slice preparation.
Topics: Animals; Dose-Response Relationship, Drug; Excitatory Amino Acids; Glutamic Acid; Hippocampus; Hypoxia; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1995 |
L-glutamate-induced changes in intracellular calcium oscillation frequency through non-classical glutamate receptor binding in cultured rat myocardial cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart; Intracellular Fluid; Kainic Acid; Myocardium; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1995 |
The iron component of sodium nitroprusside blocks NMDA-induced glutamate accumulation and intracellular Ca2+ elevation.
Topics: Animals; Calcium; Catalase; Cells, Cultured; Cerebellum; Ferrocyanides; Glutamic Acid; Iron; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Nitroprusside; Penicillamine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Structure-Activity Relationship; Superoxide Dismutase; Vasodilator Agents | 1995 |
Intrauterine hypoxia-ischemia increases N-methyl-D-aspartate-induced cGMP formation and glutamate accumulation in cultured rat cerebellar granule cells.
Topics: Animals; Arginine; Brain Ischemia; Cells, Cultured; Cerebellar Diseases; Chronic Disease; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Fetal Hypoxia; Gestational Age; Glutamic Acid; Hypoxia, Brain; Kainic Acid; N-Methylaspartate; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley | 1995 |
Glutamate regulation of GDNF gene expression in the striatum and primary striatal astrocytes.
Topics: Animals; Astrocytes; Cells, Cultured; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Immunohistochemistry; Kainic Acid; Male; N-Methylaspartate; Neostriatum; Nerve Growth Factors; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1995 |
Mechanisms of altered LH secretion in neonatally oestrogenized male rats.
Topics: alpha-Methyltyrosine; Animals; Animals, Newborn; Drug Implants; Estradiol; Excitatory Amino Acids; Gonadotropin-Releasing Hormone; Hypothalamus; Kainic Acid; Leydig Cells; Luteinizing Hormone; Male; Mesylates; Methyltyrosines; N-Methylaspartate; Naloxone; Orchiectomy; Pituitary Gland; Rats; Rats, Wistar; Testosterone; Tyrosine 3-Monooxygenase | 1995 |
The role of excitatory amino acid pathways in the control of pituitary function in neonatally oestrogenized male rats.
Topics: Animals; Animals, Newborn; Drug Implants; Estradiol; Excitatory Amino Acids; Follicle Stimulating Hormone; Kainic Acid; Luteinizing Hormone; Male; N-Methylaspartate; Orchiectomy; Pituitary Gland; Prolactin; Rats; Rats, Wistar; Sexual Maturation; Signal Transduction; Testosterone | 1995 |
Protective effect of riluzole on excitatory amino acid-mediated neurotoxicity in motoneuron-enriched cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Survival; Cells, Cultured; Central Nervous System Diseases; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Motor Neurons; N-Methylaspartate; Rats; Receptors, Amino Acid; Riluzole; Thiazoles | 1995 |
Functional kainate-selective glutamate receptors in cultured hippocampal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Membrane Permeability; Cells, Cultured; Embryo, Mammalian; Hippocampus; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neurotoxins; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Glutamate | 1993 |
Pharmacological evidence for involvement of excitatory amino acids in aversive responses induced by intrathecal substance P in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Biphenyl Compounds; Injections, Spinal; Kainic Acid; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Neurokinin-1; Substance P | 1993 |
Brief calcium transients evoked by glutamate receptor agonists in rat dorsal horn neurons: fast kinetics and mechanisms.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cells, Cultured; Cycloleucine; Female; Glutamates; Glutamic Acid; Ion Channel Gating; Kainic Acid; Kinetics; Lanthanum; N-Methylaspartate; Neurons; Neurotoxins; Photometry; Potassium; Pregnancy; Presynaptic Terminals; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1993 |
Evaluation of the mechanisms underlying the kainate-induced impairment of [3H]dopamine release in the rat striatum.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Electric Stimulation; Kainic Acid; Ketamine; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons, Afferent; Pipecolic Acids; Quinoxalines; Rats; Rats, Sprague-Dawley | 1993 |
Membrane currents evoked by excitatory amino acid agonists in ON bipolar cells of the mudpuppy retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Animals; Cadmium; Cell Membrane; Cobalt; Cycloleucine; Electrophysiology; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Necturus maculosus; Neurotransmitter Agents; Receptors, Amino Acid; Retina | 1993 |
Neuronal damage induced by beta-N-oxalylamino-L-alanine, in the rat hippocampus, can be prevented by a non-NMDA antagonist, 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; beta-Alanine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Quinoxalines; Rats; Rats, Wistar | 1993 |
Glutamate-evoked release of arachidonic acid from mouse brain astrocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Astrocytes; Brain; Cells, Cultured; Cerebellum; Cerebral Cortex; Corpus Striatum; Cycloleucine; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Kinetics; Mice; N-Methylaspartate; Neurotoxins; Organ Specificity; Quisqualic Acid; Receptors, Glutamate; Time Factors; Tritium | 1994 |
Dynamics of the actions of tetrahydro-9-aminoacridine and 9-aminoacridine on glutamatergic currents: concentration-jump studies in cultured rat hippocampal neurons.
Topics: Aminacrine; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Hippocampus; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Tacrine | 1994 |
Ionotropic glutamate receptor types leading to adenosine-mediated inhibition of electrically evoked [3H]-noradrenaline release in rabbit brain cortex slices.
Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Electric Stimulation; Female; In Vitro Techniques; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Rabbits; Receptors, Glutamate | 1993 |
Differential effects of NBQX on the distal and local toxicity of glutamate agonists administered intra-hippocampally.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Diazepam; Hippocampus; Injections; Kainic Acid; Limbic System; N-Methylaspartate; Neurons; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate | 1993 |
The lateral hypothalamus: a primary site mediating excitatory amino acid-elicited eating.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Feeding Behavior; Glutamates; Glutamic Acid; Hypothalamic Area, Lateral; Injections; Kainic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley | 1993 |
Metabotropic and ionotropic excitatory amino acid receptor agonists induce different behavioral effects in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ibotenic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Seizures | 1993 |
Metabotropic excitatory amino acid receptor agonists selectively potentiate behavioral effects induced by ionotropic excitatory amino acid receptor agonists in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; Drug Synergism; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Neurotoxins; Pentylenetetrazole; Receptors, Glutamate; Seizures | 1993 |
Dexamethasone potentiates NMDA receptor-mediated neuronal injury in the postnatal rat.
Topics: Aldosterone; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Autoradiography; Blood Glucose; Brain; Dexamethasone; Electron Transport Complex IV; Glutamates; Glutamic Acid; Kainic Acid; Metyrapone; N-Methylaspartate; Neurotransmitter Agents; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Influence of excitatory amino acid receptor subtypes on the electrophysiological activity of dopaminergic and nondopaminergic neurons in rat substantia nigra.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dopamine; Electrophysiology; Glutamates; Glutamic Acid; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Substantia Nigra | 1994 |
Evidence that GYKI 52466, a novel non-NMDA antagonist enhances the decay of kainate-induced current in cultured chicken cortical neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebral Cortex; Chick Embryo; Electrophysiology; Excitatory Amino Acid Antagonists; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neurotoxins; Quinoxalines | 1994 |
Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Cricetinae; Cyclic AMP; Glycine; Hydrolysis; Kainic Acid; Kidney; Male; N-Methylaspartate; Phosphatidylinositols; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1994 |
Cyclothiazide selectively potentiates AMPA- and kainate-induced [3H]norepinephrine release from rat hippocampal slices.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antihypertensive Agents; Benzothiadiazines; Drug Synergism; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Tritium; Veratridine | 1994 |
Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acids, Dicarboxylic; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cycloleucine; Cyclopropanes; Glycine; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Phosphatidylinositols; Receptors, Metabotropic Glutamate | 1994 |
Effect of local infusion of glutamate analogues into the nucleus accumbens of rats: an electrochemical and behavioural study.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dopamine; Electrochemistry; Glutamates; Infusions, Parenteral; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Nomifensine; Nucleus Accumbens; Piperazines; Rats; Rats, Sprague-Dawley; Reserpine; Tetrodotoxin | 1994 |
The effect of experimental ischaemia and excitatory amino acid agonists on the GABA and serotonin immunoreactivities in the rabbit retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cycloleucine; Dextromethorphan; Eye Proteins; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamic Acid; Intraocular Pressure; Ischemia; Kainic Acid; Kynurenic Acid; Memantine; N-Methylaspartate; Oxygen; Potassium Cyanide; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Vessels; Serotonin | 1994 |
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline protects against both AMPA and kainate-induced lesions in rat striatum in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Choline O-Acetyltransferase; Corpus Striatum; Glutamate Decarboxylase; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate | 1994 |
Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS.
Topics: Amino Acid Oxidoreductases; Animals; Astrocytes; Cell Death; Cells, Cultured; Drug Synergism; Enzyme Induction; In Vitro Techniques; Interferon-gamma; Interleukin-1; Kainic Acid; Mice; Molsidomine; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Synthase; Penicillamine; S-Nitroso-N-Acetylpenicillamine | 1994 |
Discrimination by added ions of ligands at ionotropic excitatory amino acid receptors insensitive to N-methyl-D-aspartate in rat brain using membrane binding techniques.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anions; Brain; Kainic Acid; Male; N-Methylaspartate; Radioligand Assay; Rats; Rats, Wistar; Receptors, Amino Acid; Sulfhydryl Reagents; Synaptic Membranes; Thiocyanates | 1994 |
Glutamate receptor-driven activation of transcription factors in primary neuronal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Astrocytes; Base Sequence; Binding Sites; Cell Nucleus; Cell Survival; Cells, Cultured; Cycloleucine; Embryo, Mammalian; Gene Expression; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Mice; Molecular Sequence Data; N-Methylaspartate; Neurons; Proto-Oncogene Proteins; Proto-Oncogenes; Quisqualic Acid; Rats; Receptors, Glutamate; Transcription Factors | 1994 |
Possible role of glutamatergic neurotransmission in regulating ethanol-evoked brain ascorbate release.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ascorbic Acid; Brain Chemistry; Dicarboxylic Acids; Electrophysiology; Ethanol; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Injections, Intraventricular; Kainic Acid; Male; Microelectrodes; N-Methylaspartate; Neostriatum; Piperazines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1994 |
Chondroitin sulfate proteoglycans protect cultured rat's cortical and hippocampal neurons from delayed cell death induced by excitatory amino acids.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Chondroitin Sulfates; Hippocampus; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Proteoglycans; Rats; Rats, Sprague-Dawley | 1994 |
Effects of L-glutamate on the responses to nerve stimulation in rat isolated atria.
Topics: Adrenergic Fibers; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Atrial Function; Electric Stimulation; Female; Glutamates; Glutamic Acid; Heart Atria; Heart Rate; In Vitro Techniques; Kainic Acid; Male; Muscarinic Antagonists; N-Methylaspartate; Norepinephrine; Purinergic P1 Receptor Antagonists; Quinoxalines; Rats; Rats, Wistar | 1994 |
Patch-clamp analysis of direct steroidal modulation of glutamate receptor-channels.
Topics: Animals; Estradiol; Female; Hippocampus; In Vitro Techniques; Ion Channels; Kainic Acid; Male; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pregnenolone; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Steroids | 1994 |
Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cell Line; Cycloleucine; Dizocilpine Maleate; Glioma; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Ion Channels; Kainic Acid; Kinetics; Magnesium Chloride; N-Methylaspartate; Neurotoxins; Pyrrolidinones; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Signal Transduction; Tumor Cells, Cultured | 1994 |
Neuroprotective effect of hypothermia in cortical cultures exposed to oxygen-glucose deprivation or excitatory amino acids.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Cold Temperature; Cytosol; Dizocilpine Maleate; Fetus; Glucose; Glutamic Acid; Glycine; Hypothermia, Induced; Kainic Acid; Kinetics; Mice; N-Methylaspartate; Neurons | 1994 |
Interactions between N-acetylaspartylglutamate and AMPA, kainate, and NMDA binding sites.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Dipeptides; Drug Interactions; Kainic Acid; N-Methylaspartate; Prosencephalon; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tritium | 1994 |
Comparative patch clamp studies on the kinetics and selectivity of glutamate receptor antagonism by 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) and 1-(4-amino-phenyl)-4-methyl-7,8-methyl-endioxyl-5H-2,3-benzodiaze pine (GYKI 52466).
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cells, Cultured; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Receptors, AMPA; Superior Colliculi | 1994 |
Basal forebrain cholinergic neurons are selectively vulnerable to AMPA/kainate receptor-mediated neurotoxicity.
Topics: Acetylcholine; Acetylcholinesterase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Animals; Cells, Cultured; Choline O-Acetyltransferase; Kainic Acid; Mice; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Prosencephalon; Receptors, AMPA; Receptors, Kainic Acid | 1994 |
Ethanol inhibits glutamatergic neurotransmission in nucleus accumbens neurons by multiple mechanisms.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ethanol; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Naloxone; Nucleus Accumbens; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptic Transmission | 1994 |
Propofol protects cultured rat hippocampal neurons against N-methyl-D-aspartate receptor-mediated glutamate toxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Phosphopyruvate Hydratase; Propofol; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 1994 |
Excitotoxicity of glutamate and four analogs in primary spinal cord cell cultures.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acridine Orange; Animals; Cell Death; Cells, Cultured; Dizocilpine Maleate; Ethidium; Glutamic Acid; Kainic Acid; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Quisqualic Acid; Spinal Cord; Staining and Labeling | 1994 |
NMDA and non-NMDA receptor-mediated release of [3H]GABA from granule cell dendrites of rat olfactory bulb.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dendrites; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glycine; Granulocytes; Kainic Acid; Male; N-Methylaspartate; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1995 |
Early in vitro development of voltage- and transmitter-gated currents in GABAergic amacrine cells.
Topics: Animals; Autoradiography; Cells, Cultured; Cellular Senescence; Chick Embryo; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Interneurons; Ion Channel Gating; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Quisqualic Acid; Receptors, GABA; Receptors, Glutamate; Retina; Time Factors; Tritium | 1994 |
Inhibitory effects of salmon calcitonin on the tail-biting and scratching behavior induced by substance P and three excitatory amino acids.
Topics: Afferent Pathways; Animals; Calcitonin; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Injections, Intraventricular; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Pain; Pain Measurement; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurokinin-1; Spinal Cord; Substance P; Tail | 1994 |
Regional expression of inducible heat shock protein-70 mRNA in the rat brain following administration of convulsant drugs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain Chemistry; Convulsants; Gene Expression Regulation; Hexachlorocyclohexane; HSP70 Heat-Shock Proteins; Kainic Acid; Male; N-Methylaspartate; Nerve Tissue Proteins; Organ Specificity; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger | 1994 |
NMDA, kainate, and AMPA depolarize nondopamine neurons in the rat ventral tegmentum.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Tegmentum Mesencephali | 1995 |
Glycine release from hippocampal slices in developing and ageing mice: modulation by glutamatergic receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Dizocilpine Maleate; Female; Glycine; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; N-Methylaspartate; Potassium; Quisqualic Acid; Receptors, Glutamate; Tetrazoles | 1994 |
Taurine release from mouse hippocampal slices: effects of glutamatergic substances and hypoxia.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Female; Glutamic Acid; Hippocampus; Kainic Acid; Male; Mice; N-Methylaspartate; Nitrogen; Oxygen; Potassium; Quisqualic Acid; Taurine | 1994 |
Intracerebral microdialysis combined with recording of extracellular field potential: a novel method for investigation of depolarizing drugs in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Polarity; Electroencephalography; Excitatory Amino Acids; Extracellular Space; Glutamic Acid; Kainic Acid; Male; Membrane Potentials; Microdialysis; N-Methylaspartate; Neostriatum; Rats; Rats, Sprague-Dawley | 1994 |
Release of [3H]GABA evoked by glutamate receptor agonists in cultured chick retina cells: effect of Ca2+.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Kainic Acid; N-Methylaspartate; Nicotinic Acids; Nipecotic Acids; Oximes; Quisqualic Acid; Retina; Tritium | 1994 |
Exposure of rat spinal neurones to NMDA, AMPA and kainate produces only short-term enhancements of responses to noxious and non-noxious stimuli.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Hot Temperature; Kainic Acid; Male; N-Methylaspartate; Neurons; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Wistar; Spinal Cord; Time Factors | 1994 |
Inhibition by ethanol of excitatory amino acid receptors and nicotinic acetylcholine receptors at rat locus coeruleus neurons.
Topics: Action Potentials; Animals; Ethanol; Kainic Acid; Locus Coeruleus; Male; N-Methylaspartate; Nicotine; Rats; Rats, Wistar; Receptors, Amino Acid; Receptors, Nicotinic; Substance P | 1994 |
Presynaptic ionotropic glutamate receptors modulate in vivo release and metabolism of striatal dopamine, noradrenaline, and 5-hydroxytryptamine: involvement of both NMDA and AMPA/kainate subtypes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Kainic Acid; Male; Microdialysis; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Serotonin | 1994 |
Neuroprotective effect of free radical scavengers on beta-N-oxalylamino-L-alanine (BOAA)-induced neuronal damage in rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dose-Response Relationship, Drug; Free Radical Scavengers; Hippocampus; Kainic Acid; Male; Motor Neuron Disease; N-Methylaspartate; Neurons; Rats; Rats, Wistar | 1994 |
Involvement of free radicals in excitotoxicity in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cell Death; Cells, Cultured; Cyclic N-Oxides; Dizocilpine Maleate; Electrophysiology; Free Radical Scavengers; Free Radicals; Hydroxyl Radical; Kainic Acid; Male; N-Methylaspartate; Neurons; Nitrogen Oxides; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1995 |
Effects of the epileptogenic agent strychnine on membrane currents elicited by agonists of the NMDA and non-NMDA receptors in Xenopus oocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Glycine; Ion Channels; Kainic Acid; N-Methylaspartate; Oocytes; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Strychnine; Xenopus laevis | 1995 |
Felbamate selectively blocks in vitro hippocampal kainate-induced irreversible electrical changes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Electrophysiology; Felbamate; Hippocampus; Kainic Acid; Kynurenic Acid; Lamotrigine; Male; N-Methylaspartate; Pentobarbital; Phenylcarbamates; Propylene Glycols; Rats; Rats, Wistar; Triazines | 1995 |
Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Antibodies, Monoclonal; Cell Death; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acids; Fetus; Glutamic Acid; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Kainic Acid; Kinetics; N-Methylaspartate; Nerve Degeneration; Nerve Growth Factors; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sialoglycoproteins | 1995 |
A glutamate-activated chloride current in cone-driven ON bipolar cells of the white perch retina.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chloride Channels; Chlorides; Cycloleucine; Dendrites; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurotoxins; Patch-Clamp Techniques; Perches; Picrotoxin; Quinoxalines; Quisqualic Acid; Receptors, Metabotropic Glutamate; Retina; Retinal Cone Photoreceptor Cells; Strychnine | 1995 |
Dopamine enhances glutamate-activated currents in spinal motoneurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apomorphine; Base Sequence; Benzazepines; Chick Embryo; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA Primers; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression; Glutamic Acid; Ion Channels; Kainic Acid; Kinetics; Membrane Potentials; Molecular Sequence Data; Motor Neurons; N-Methylaspartate; Patch-Clamp Techniques; Polymerase Chain Reaction; Receptors, Dopamine D1; RNA, Messenger; Spinal Cord; Time Factors | 1995 |
Single glutamate channels in CA1 pyramidal neurones after transient ischaemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Gerbillinae; Kainic Acid; N-Methylaspartate; Patch-Clamp Techniques; Pyramidal Cells; Receptors, Glutamate; Time Factors | 1995 |
Development of kainic acid and N-methyl-D-aspartic acid toxicity in organotypic hippocampal cultures.
Topics: Animals; Eosine Yellowish-(YS); Hematoxylin; Hippocampus; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Nissl Bodies; Organ Culture Techniques; Propidium; Rats; Rats, Sprague-Dawley; Staining and Labeling | 1995 |
Regulation of spontaneous phasic firing of rat supraoptic vasopressin neurones in vivo by glutamate receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Kainic Acid; Male; N-Methylaspartate; Oxytocin; Rats; Receptors, Glutamate; Supraoptic Nucleus; Vasopressins | 1995 |
Delayed antagonism of calpain reduces excitotoxicity in cultured neurons.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Calpain; Cell Survival; Cells, Cultured; Cerebellum; Dipeptides; Enzyme Activation; Glutamic Acid; Hippocampus; Kainic Acid; Leucine; N-Methylaspartate; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Rats; Receptors, N-Methyl-D-Aspartate; Spectrin; Time Factors | 1995 |
1-BCP, a memory-enhancing agent, selectively potentiates AMPA-induced [3H]norepinephrine release in rat hippocampal slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Dioxoles; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Memory; N-Methylaspartate; Norepinephrine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 1995 |
Developmental change of the potentiation of NMDA response by spermine.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Drug Synergism; Electrophysiology; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Nystatin; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Spermine; Ventromedial Hypothalamic Nucleus | 1995 |
Properties of AMPA receptors expressed in rat cerebellar granule cell cultures: Ca2+ influx studies.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzothiadiazines; Calcium; Calcium Radioisotopes; Cell Survival; Cells, Cultured; Cerebellum; Cobalt; Concanavalin A; Excitatory Amino Acids; Kainic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, AMPA; Wheat Germ Agglutinins | 1995 |
Excitatory amino acid receptor ligands: asymmetric synthesis, absolute stereochemistry and pharmacology of (R)- and (S)-homoibotenic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Ligands; N-Methylaspartate; Radioligand Assay; Rats; Receptors, Glutamate; Stereoisomerism; Structure-Activity Relationship | 1995 |
GFAP-positive hippocampal astrocytes in situ respond to glutamatergic neuroligands with increases in [Ca2+]i.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Rats | 1995 |
Ca2+ permeable AMPA/kainate channels permit rapid injurious Ca2+ entry.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cell Count; Cells, Cultured; Cobalt; Dose-Response Relationship, Drug; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Nerve Degeneration; Receptors, AMPA; Receptors, Kainic Acid | 1995 |
Effects of nitric oxide availability on responses of spinal wide dynamic range neurons to excitatory amino acids.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Analysis of Variance; Animals; Arginine; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Penicillamine; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; S-Nitroso-N-Acetylpenicillamine; Spinal Canal | 1995 |
NMDA and kainate induce internucleosomal DNA cleavage associated with both apoptotic and necrotic cell death in the neonatal rat brain.
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Dizocilpine Maleate; DNA Damage; Electrophoresis, Agar Gel; Genetic Techniques; Kainic Acid; Microscopy, Electron; N-Methylaspartate; Necrosis; Neuroprotective Agents; Nucleosomes; Rats; Time Factors | 1995 |
In situ transblot and immunocytochemical comparisons of astrocytic connexin-43 responses to NMDA and kainic acid in rat brain.
Topics: Animals; Astrocytes; Connexin 43; Epitopes; Gap Junctions; Immunoblotting; Immunohistochemistry; Kainic Acid; Male; Membranes, Artificial; N-Methylaspartate; Rats; Rats, Sprague-Dawley | 1995 |
Identification of functional ionotropic glutamate receptor proteins in pancreatic beta-cells and in islets of Langerhans.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibody Specificity; Cell Line; Cell Membrane; Female; Glutamic Acid; Immunoblotting; Insulin; Insulin Secretion; Islets of Langerhans; Kainic Acid; Molecular Sequence Data; N-Methylaspartate; Peptide Fragments; Rabbits; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Kainic Acid | 1995 |
Alteration in the glial cell metabolism of glutamate by kainate and N-methyl-D-aspartate.
Topics: Animals; Arginine; Brain; Brain Chemistry; Glutamate-Ammonia Ligase; Glutamate-Cysteine Ligase; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neuroglia; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Phosphopyruvate Hydratase; Rats; Rats, Wistar | 1995 |
Staurosporine-induced neuronal apoptosis.
Topics: Alkaloids; Animals; Apoptosis; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Nerve Degeneration; Neurons; Staurosporine; Time Factors | 1995 |
Interaction between glutamate and GABA on 3H-noradrenaline release from rat hypothalamus.
Topics: Animals; Baclofen; Drug Interactions; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Hypothalamus; Kainic Acid; Male; N-Methylaspartate; Norepinephrine; Potassium; Rats; Rats, Sprague-Dawley; Tritium | 1995 |
In vitro kainate injury to large, SMI-32(+) spinal neurons is Ca2+ dependent.
Topics: Animals; Biomarkers; Calcium; Calcium Channels; Cell Death; Cells, Cultured; Cobalt; Immunohistochemistry; Kainic Acid; Mice; Motor Neurons; N-Methylaspartate; Neurofilament Proteins; Neurons; Receptors, AMPA; Spinal Cord | 1995 |
L-type Ca2+ channels mediate joint modulation by gamma-amino-butyric acid and glutamate of [Ca2+]i and neuropeptide secretion in immortalized gonadodropin-releasing hormone neurons.
Topics: Bicuculline; Calcium; Calcium Channels; Cell Line, Transformed; Cytoplasm; gamma-Aminobutyric Acid; Glutamic Acid; Gonadotropin-Releasing Hormone; Kainic Acid; Muscimol; N-Methylaspartate; Neurons; Neuropeptides; Potassium Chloride | 1995 |
Transient coupling of NMDA receptor with ip3 production in cultured cells of the avian retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Chick Embryo; Cycloleucine; Dizocilpine Maleate; gamma-Aminobutyric Acid; Inositol 1,4,5-Trisphosphate; Kainic Acid; N-Methylaspartate; Neurotoxins; Receptors, N-Methyl-D-Aspartate; Retina; Time Factors | 1995 |
Seizures induced by homocysteine in rats during ontogenesis.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acids; Homocysteine; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Glutamate; Seizures | 1995 |
Characterization of the excitoprotective actions of N-methyl-D-aspartate in cultured cerebellar granule neurons.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; Cycloheximide; Dizocilpine Maleate; Dose-Response Relationship, Drug; Down-Regulation; Glutamic Acid; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 1995 |
Glutamate receptor-mediated calcium surges in neurons derived from P19 cells.
Topics: Animals; Calcium; Cell Differentiation; Dizocilpine Maleate; Egtazic Acid; Embryonal Carcinoma Stem Cells; Glutamic Acid; Glycine; Kainic Acid; Magnesium; Mice; N-Methylaspartate; Neoplastic Stem Cells; Neurons; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Tretinoin; Tumor Cells, Cultured | 1995 |
Protective action of zinc against glutamate neurotoxicity in cultured retinal neurons.
Topics: Animals; Cell Survival; Cells, Cultured; Chlorides; Dose-Response Relationship, Drug; Fetus; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Retina; Zinc Compounds | 1995 |
Phospholipase A2 modulates different subtypes of excitatory amino acid receptors: autoradiographic evidence.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid | 1993 |
Reduction of striatal N-methyl-D-aspartate toxicity by inhibition of nitric oxide synthase.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Corpus Striatum; Glutamate-Ammonia Ligase; Kainic Acid; N-Methylaspartate; Nitric Oxide Synthase; Nitroarginine; Phosphopyruvate Hydratase; Rats | 1993 |
Cyclothiazide reverses AMPA receptor antagonism of the 2,3-benzodiazepine, GYKI 53655.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Benzothiadiazines; Cerebral Cortex; Diuretics; Excitatory Amino Acid Antagonists; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, AMPA; Sodium Chloride Symporter Inhibitors | 1993 |
N-methyl-D-aspartate- and non-N-methyl-D-aspartate-evoked adenosine release from rat cortical slices: distinct purinergic sources and mechanisms of release.
Topics: 5'-Nucleotidase; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport; Calcium; Cerebral Cortex; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Nucleosides; Purines; Rats | 1993 |
Dipsogenic effects of excitatory amino acid agonists in pigeons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Columbidae; Drinking; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Pipecolic Acids; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 1993 |
Binding of [3H]MK-801, NMDA-displaceable [3H]glutamate, [3H]glycine, [3H]spermidine, [3H]kainate and [3H]AMPA to regionally discrete brain membranes of the gerbil: a biochemical study.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain; Cell Membrane; Dizocilpine Maleate; Female; Gerbillinae; Glutamates; Glutamic Acid; Glycine; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Receptors, Glutamate; Spermidine; Thiocyanates; Tissue Distribution | 1993 |
Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cerebral Cortex; Cycloleucine; Glycine; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Neurotoxins; Phosphatidylinositols; Rats; Receptors, Glutamate; Spinal Cord; Thalamus | 1993 |
N-methyl-D-aspartate induces regular firing patterns in the cat lateral habenula in vivo.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cats; Ibotenic Acid; Iontophoresis; Kainic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Neurons; Quisqualic Acid; Receptors, Amino Acid; Stereotaxic Techniques; Thalamus | 1993 |
Norbinaltorphimine protection against N-methyl-D-aspartic acid-induced convulsions and mortality.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Binding, Competitive; Brain; Ibotenic Acid; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Naltrexone; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Respiratory responses to microinjection of excitatory amino acid agonists in ventrolateral regions of the lateral parabrachial nucleus in the cat.
Topics: Animals; Axonal Transport; Brain; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Female; Glutamates; Glutamic Acid; Horseradish Peroxidase; Kainic Acid; Male; Microinjections; N-Methylaspartate; Neurons; Quisqualic Acid; Receptors, Glutamate; Respiration; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins | 1993 |
Enflurane inhibits NMDA, AMPA, and kainate-induced currents in Xenopus oocytes expressing mouse and human brain mRNA.
Topics: Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cerebral Cortex; Enflurane; Female; Humans; Ibotenic Acid; Ion Channels; Kainic Acid; Male; Mice; Mice, Inbred BALB C; N-Methylaspartate; Oocytes; Receptors, Glutamate; RNA, Messenger; Species Specificity; Xenopus laevis | 1993 |
Are chimeric kainate/N-methyl-D-aspartate receptors expressed in Xenopus oocytes from mammalian and amphibian RNA?
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Calcium; Female; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Oocytes; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; RNA; Xenopus | 1993 |
Glutamate receptor agonists enhance the expression of BDNF mRNA in cultured cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Kinetics; Kynurenic Acid; Molecular Weight; N-Methylaspartate; Nerve Growth Factors; Nerve Tissue Proteins; Quinoxalines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Tetrodotoxin; Transcription, Genetic | 1993 |
Electrophysiological evidence for the existence of NMDA and non-NMDA receptors on rat ventral tegmental dopamine neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Electrophysiology; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Neurons; Pipecolic Acids; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Tegmentum Mesencephali | 1993 |
Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Electrophysiology; Glycine; Hippocampus; Ibotenic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine | 1993 |
Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Cloning, Molecular; Dizocilpine Maleate; DNA; Female; Frontal Lobe; Gene Library; Glutamates; Glutamic Acid; Glycine; Humans; Ibotenic Acid; Kainic Acid; Macromolecular Substances; Molecular Sequence Data; N-Methylaspartate; Oocytes; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sequence Homology, Amino Acid; Transcription, Genetic; Xenopus laevis | 1993 |
Effects of phencyclidine on spontaneous and excitatory amino acid-induced activity of ventral tegmental dopamine neurons: an extracellular in vitro study.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Dopamine; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurons; Phencyclidine; Rats; Rats, Sprague-Dawley; Tegmentum Mesencephali | 1993 |
Medium-dependent dissociation of cytotoxic and GABA-releasing effects of N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and kainate in rat cortical cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; gamma-Aminobutyric Acid; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 1993 |
Induction of astrocyte glutamine synthetase activity by the Lathyrus toxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid (beta-L-ODAP).
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; Animals, Newborn; Astrocytes; Cell Death; Cells, Cultured; Cerebral Cortex; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Induction; Glutamate-Ammonia Ligase; Ibotenic Acid; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurotoxins; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1993 |
Glutamate receptor-induced cyclic GMP formation in primary cultures of mesencephalic neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Arginine; Carbachol; Cells, Cultured; Cyclic GMP; Fetus; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Kinetics; Mesencephalon; Mice; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Phorbol 12,13-Dibutyrate; Quinoxalines; Receptors, Glutamate | 1993 |
Voltage- and transmitter-gated currents of all-amacrine cells in a slice preparation of the rat retina.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cobalt; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; In Vitro Techniques; Ion Channel Gating; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Potassium Channels; Quinoxalines; Rats; Receptors, Amino Acid; Retina; Retinal Ganglion Cells; Sodium Channels; Strychnine; Synapses; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin | 1993 |
Reconstitution of glutamate receptor proteins purified from Xenopus central nervous system into artificial bilayers.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Chromatography, Affinity; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Lipid Bilayers; N-Methylaspartate; Receptors, Glutamate; Xenopus | 1993 |
NMDA receptors mediate neuronal burst firing in rat somatosensory cortex in vivo.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ibotenic Acid; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex | 1993 |
Lateral hypothalamic injections of glutamate, kainic acid, D,L-alpha-amino-3-hydroxy-5-methyl-isoxazole propionic acid or N-methyl-D-aspartic acid rapidly elicit intense transient eating in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Eating; Glutamates; Glutamic Acid; Hypothalamic Area, Lateral; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
Kainate toxicity in energy-compromised rat hippocampal slices: differences between oxygen and glucose deprivation.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Electrophysiology; Energy Metabolism; Evoked Potentials; Glucose; Hippocampus; Hypoxia, Brain; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Magnesium; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
AMPA and NMDA binding sites in the hypothalamic lateral tuberal nucleus: implications for Huntington's disease.
Topics: Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Glutamates; Glutamic Acid; Humans; Huntington Disease; Hypothalamic Area, Lateral; Ibotenic Acid; Kainic Acid; Middle Aged; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate | 1993 |
Excitatory amino acid-induced slow biphasic responses of free intracellular calcium in human neuroblastoma cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Calcium; Cycloleucine; Glutamates; Glutamic Acid; Humans; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Receptors, Glutamate; Tumor Cells, Cultured | 1993 |
Selective antagonism of native and cloned kainate and NMDA receptors by polyamine-containing toxins.
Topics: Animals; Arthropod Venoms; Cloning, Molecular; Excitatory Amino Acid Antagonists; Female; Indoleacetic Acids; Kainic Acid; Male; N-Methylaspartate; Oocytes; Phenols; Phenylacetates; Polyamines; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA; Spider Venoms; Transcription, Genetic; Xenopus | 1993 |
Excitatory amino acid receptor mediation of sensory inputs to functionally identified dorsal horn neurons in cat spinal cord.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cats; Decerebrate State; Evoked Potentials; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Ketamine; Kynurenic Acid; N-Methylaspartate; Neurons; Quinoxalines; Quisqualic Acid; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synapses | 1993 |
7-Chlorokynurenate prevents NMDA-induced and kainate-induced striatal lesions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Diseases; Choline O-Acetyltransferase; Corpus Striatum; Dose-Response Relationship, Drug; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine | 1993 |
Dextromethorphan blocks N-methyl-D-aspartate-induced currents and voltage-operated inward currents in cultured cortical neurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amlodipine; Animals; Barium; Calcium Channels; Cells, Cultured; Cerebral Cortex; Dextromethorphan; Electrophysiology; Female; Kainic Acid; N-Methylaspartate; Neurons; PC12 Cells; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Channels | 1993 |
Glutamate receptor-mediated currents and toxicity in embryonal carcinoma cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Carcinoma, Embryonal; Cell Differentiation; Dizocilpine Maleate; Electrophysiology; Female; Immunohistochemistry; Indicators and Reagents; Ion Channels; Kainic Acid; Mice; N-Methylaspartate; Neuroglia; Neurons; Pregnancy; Quinoxalines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Tretinoin; Tumor Cells, Cultured | 1993 |
Toward an understanding of the role of glutamate in experimental parkinsonism: agonist-sensitive sites in the basal ganglia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basal Ganglia; Cycloleucine; Electromyography; Glutamates; Glutamic Acid; Kainic Acid; Male; Muscles; N-Methylaspartate; Parkinson Disease; Rats; Receptors, Glutamate | 1993 |
Regulation of sigma activity by the amino-terminus of substance P in the mouse spinal cord: involvement of phencyclidine (PCP) sites not linked to N-methyl-D-aspartate (NMDA) activity.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Drug Synergism; Guanidines; Haloperidol; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Peptide Fragments; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Receptors, sigma; Spinal Cord; Substance P; Up-Regulation | 1993 |
GABAA receptor-mediated inhibition of N-methyl-D-aspartate-evoked [3H]dopamine release from mesencephalic cell cultures.
Topics: Animals; Baclofen; Cells, Cultured; Dopamine; Flunitrazepam; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Kainic Acid; Mesencephalon; Muscimol; N-Methylaspartate; Picrotoxin; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA; Ventral Tegmental Area | 1994 |
Localization and interaction of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors of lamprey spinal neurons.
Topics: Animals; Biophysical Phenomena; Biophysics; Dendrites; In Vitro Techniques; Kainic Acid; Lampreys; Membrane Potentials; Models, Neurological; N-Methylaspartate; Neurons; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1995 |
Interactions between opioid drugs and propofol in laboratory models of seizures.
Topics: Analgesics, Opioid; Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Fentanyl; Kainic Acid; Meperidine; Mice; Mice, Inbred Strains; Morphine; N-Methylaspartate; Propofol; Seizures | 1995 |
Ethanol inhibits NMDA-receptor mediated regulation of immediate early gene expression.
Topics: Alcoholism; Animals; Brain; Caffeine; Dizocilpine Maleate; Ethanol; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Substance Withdrawal Syndrome; Tissue Distribution | 1993 |
Modulation of the glutamate-evoked release of arachidonic acid from mouse cortical neurons: involvement of a pH-sensitive membrane phospholipase A2.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amiloride; Ammonium Chloride; Animals; Arachidonic Acid; Calcium; Cell Membrane; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Embryo, Mammalian; Female; Glutamic Acid; Harmaline; Hydrogen-Ion Concentration; Immunohistochemistry; Kainic Acid; Kinetics; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Phospholipases A; Phospholipases A2; Pregnancy; Time Factors; Tritium | 1995 |
Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arginine; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Indomethacin; Kainic Acid; Kinetics; Masoprocol; N-Methylaspartate; Neurons; Nitroarginine; Prosencephalon; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence; Time Factors | 1995 |
Distinct neuroprotective profiles for sigma ligands against N-methyl-D-aspartate (NMDA), and hypoxia-mediated neurotoxicity in neuronal culture toxicity studies.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzofurans; Brain Ischemia; Cell Death; Cells, Cultured; Dizocilpine Maleate; Hypoxia; Kainic Acid; Ligands; N-Methylaspartate; Neurons; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Phencyclidine; Receptors, sigma | 1995 |
Lactation-induced deficits in NMDA receptor-mediated cortical and hippocampal activation: changes in NMDA receptor gene expression and brainstem activation.
Topics: Animals; Animals, Suckling; Blotting, Northern; Brain Stem; Cerebral Cortex; Diestrus; Female; Gene Expression; Hippocampus; Kainic Acid; Lactation; N-Methylaspartate; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1994 |
Growth conditions differentially modulate the vulnerability of developing cerebellar granule cells to excitatory amino acids.
Topics: Animals; Calcium Radioisotopes; Cells, Cultured; Cerebellum; Excitatory Amino Acids; GABA Agonists; GABA Antagonists; Glutamic Acid; Immunohistochemistry; Kainic Acid; Membrane Potentials; N-Methylaspartate; Potassium; Rats; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tetrazolium Salts; Thiazoles | 1994 |
Sodium nitroprusside modulates NMDA response in the rat supraoptic neurons in vitro.
Topics: Animals; Arginine; Cyclic GMP; Ferricyanides; In Vitro Techniques; Isosorbide Dinitrate; Kainic Acid; Male; Membrane Potentials; N-Methylaspartate; Neurons; Nitroarginine; Nitroprusside; Protein Kinases; Quisqualic Acid; Rats; Rats, Wistar; Supraoptic Nucleus | 1994 |
Metabotropic glutamate receptor agonist DCG-IV as NMDA receptor agonist in immature rat hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Glycine; Hippocampus; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 1994 |
Bilateral intranigral NMDA blockade increases status duration and neuronal injury from systemic kainic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Blood Pressure; Carbon Dioxide; Diazepam; Drug Synergism; Electroencephalography; Functional Laterality; Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Immunohistochemistry; Injections, Intravenous; Kainic Acid; Male; Microinjections; N-Methylaspartate; Neurons; Oxygen; Partial Pressure; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Substantia Nigra; Time Factors | 1994 |
Glutamate-induced intracellular calcium changes and neurotoxicity in cortical neurons in vitro: effect of chemical ischemia.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cell Hypoxia; Cells, Cultured; Dizocilpine Maleate; Glutamic Acid; Glycine; Kainic Acid; N-Methylaspartate; Neurons; Nimodipine; Potassium Chloride; Potassium Cyanide; Prosencephalon; Rats; Rats, Sprague-Dawley | 1994 |
Chronic mild acidosis specifically reduces functional expression of N-methyl-D-aspartate receptors and increases long-term survival in primary cultures of cerebellar granule cells.
Topics: Acidosis; Animals; Cell Survival; Cells, Cultured; Cerebellum; Chronic Disease; Electrophysiology; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 1994 |
Melatonin protects primary cultures of cerebellar granule neurons from kainate but not from N-methyl-D-aspartate excitotoxicity.
Topics: Animals; Cerebellum; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Melatonin; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats | 1995 |
Stress-induced dopamine release in the neostriatum: evaluation of the role of action potentials in nigrostriatal dopamine neurons or local initiation by endogenous excitatory amino acids.
Topics: 2-Amino-5-phosphonovalerate; 3,4-Dihydroxyphenylacetic Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Corpus Striatum; Dopamine; Electroshock; Homovanillic Acid; Kainic Acid; Male; N-Methylaspartate; Neostriatum; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Stress, Psychological; Substantia Nigra; Tetrodotoxin | 1993 |
Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in hippocampal neurons.
Topics: Animals; Base Sequence; Blotting, Western; Calcium; Cell Survival; Cells, Cultured; Embryo, Mammalian; Fibroblast Growth Factor 2; Gene Expression; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Kinetics; Molecular Sequence Data; N-Methylaspartate; Neurons; Neurotoxins; Oligodeoxyribonucleotides; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1993 |
Excitatory amino acid-induced phosphoinositide hydrolysis in Müller glia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Chickens; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hydrolysis; Inositol Phosphates; Kainic Acid; N-Methylaspartate; Neuroglia; Quinoxalines; Quisqualic Acid; Receptors, Amino Acid; Retina; Tritium | 1993 |
Differential responses in cyclic GMP formation induced by excitatory amino acids (EAA) and sodium nitroprusside (SNP) in various regions of the brain and of rats of varied age.
Topics: Aging; Amino Acids; Animals; Brain; Cyclic GMP; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Nitroprusside; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sex Characteristics | 1993 |
Endogenous nitric oxide inhibits NMDA- and kainate- responses by a negative feedback system in rat hippocampal neurons.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Arginine; Calcium; Cells, Cultured; Cyclic GMP; Feedback; Glutamates; Glutamic Acid; Hemoglobins; Hippocampus; Kainic Acid; N-Methylaspartate; Neurons; Nitric Oxide; Nitroarginine; Osmolar Concentration; Rats; Rats, Wistar; Receptors, Amino Acid | 1993 |
Comparison of double fluorescence staining and LDH-test for monitoring cell viability in vitro.
Topics: Animals; Biomarkers; Cell Survival; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Cytological Techniques; Fluoresceins; Fluorescent Dyes; Glutamates; Glutamic Acid; Hydrolysis; Kainic Acid; L-Lactate Dehydrogenase; Microscopy, Fluorescence; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neuroglia; Neurons; Neurotoxins; Propidium; Quinolinic Acid; Rats; Rats, Wistar | 1993 |
Neuroprotective activity of acetyl-L-carnitine: studies in vitro.
Topics: Acetylcarnitine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood Physiological Phenomena; Cattle; Cell Death; Cells, Cultured; Cerebral Cortex; Culture Media; Energy Metabolism; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Hippocampus; Humans; Kainic Acid; N-Methylaspartate; Neurons; Peptide Fragments; Rats | 1994 |
Heterocarrier-mediated reciprocal modulation of glutamate and glycine release in rat cerebral cortex and spinal cord synaptosomes.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium; Spinal Cord; Synaptosomes | 1994 |
An ibotenate-selective metabotropic glutamate receptor mediates protein phosphorylation in cultured hippocampal pyramidal neurons.
Topics: Animals; Calcium; Cycloleucine; Diglycerides; Embryo, Mammalian; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Inositol; Inositol Phosphates; Kainic Acid; Myristic Acid; Myristic Acids; N-Methylaspartate; Nerve Tissue Proteins; Neurotoxins; Pertussis Toxin; Phosphatidylcholines; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Protein Kinase C; Pyramidal Cells; Quisqualic Acid; Rats; Receptors, Glutamate; Stearic Acids; Virulence Factors, Bordetella | 1994 |
Release of 3H-noradrenaline by excitatory amino acids from rat mediobasal hypothalamus and the influence of aging.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Amino Acids; Animals; Glutamates; Glutamic Acid; Hypothalamus, Middle; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Rats; Tritium | 1994 |
Activation of brain acetylcholine receptors by neuromuscular blocking drugs. A possible mechanism of neurotoxicity.
Topics: Acetylcholine; Anesthesia, General; Animals; Atracurium; Brain; Calcium; Convulsants; Dose-Response Relationship, Drug; Enflurane; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Isoquinolines; Kainic Acid; Male; N-Methylaspartate; Neuromuscular Nondepolarizing Agents; Neurotoxins; Nicotine; Pancuronium; Phenytoin; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Time Factors; Tubocurarine; Vecuronium Bromide | 1994 |
The effect of L-glutamate on the afferent resting activity in the cephalopod statocyst.
Topics: Action Potentials; Afferent Pathways; Animals; Aspartic Acid; Decapodiformes; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Kainic Acid; Male; Mollusca; N-Methylaspartate; Nerve Fibers; Octopodiformes; Postural Balance; Quisqualic Acid; Species Specificity | 1994 |
Glutamate uptake blockade induces striatal dopamine release in 6-hydroxydopamine rats with intrastriatal grafts: evidence for host modulation of transplanted dopamine neurons.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Diseases; Brain Tissue Transplantation; Corpus Striatum; Dopamine; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kainic Acid; Male; Mesencephalon; N-Methylaspartate; Neurons; Oxidopamine; Rats; Tyrosine 3-Monooxygenase | 1994 |
The activity of opioid analgesics in seizure models utilizing N-methyl-DL-aspartic acid, kainic acid, bicuculline and pentylenetetrazole.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Bicuculline; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Kainic Acid; Male; Mice; N-Methylaspartate; Naloxone; Pentylenetetrazole; Seizures | 1994 |
Release of chicken luteinising hormone-releasing hormone-I (cLHRH-I) by mediobasal hypothalamus in the cockerel: validation of an incubation system and effect of excitatory amino acids.
Topics: Amino Acids; Animals; Chickens; Glutamates; Glutamic Acid; Gonadotropin-Releasing Hormone; Hypothalamus, Middle; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Pyrrolidonecarboxylic Acid; Radioimmunoassay | 1994 |
Fos protein induction, neuropathology, and pharmacological protection after excitotoxic brain insult.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Injections; Kainic Acid; Male; N-Methylaspartate; Neurotoxins; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Time Factors | 1994 |
Properties of GABA and glutamate responses in identified glial cells of the mouse hippocampal slice.
Topics: Animals; Barium; Electrodes; Electrophysiology; Glial Fibrillary Acidic Protein; Glutamates; Glutamic Acid; Hippocampus; Immunohistochemistry; In Vitro Techniques; Kainic Acid; Mice; N-Methylaspartate; Neuroglia; Potassium Channels; Receptors, GABA-A; Receptors, Glutamate | 1994 |
Glutamate agonists and [3H]GABA release from rat hippocampal slices: involvement of metabotropic glutamate receptors in the quisqualate-evoked release.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Kinetics; Male; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1994 |
Changes in oxygenation states of rat brain tissues during glutamate-related epileptic seizures--near-infrared study.
Topics: Animals; Brain; Dizocilpine Maleate; Electroencephalography; Electron Transport Complex IV; Epilepsy; Glutamates; Glutamic Acid; Hemoglobins; Kainic Acid; Male; N-Methylaspartate; Oxidation-Reduction; Oxygen; Rats; Rats, Wistar; Spectrophotometry, Infrared | 1994 |
A novel approach for studying septo-hippocampal cholinergic neurons in freely moving rats: a microdialysis study with dual-probe design.
Topics: Acetylcholine; Animals; Brain; Brain Chemistry; Electric Stimulation; Hippocampus; Kainic Acid; Male; Microdialysis; N-Methylaspartate; Neurons; Parasympathetic Nervous System; Rats; Rats, Wistar; Tetrodotoxin | 1994 |
Excitatory amino acid receptors in glial progenitor cells: molecular and functional properties.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Cerebral Cortex; DNA-Binding Proteins; Early Growth Response Protein 1; Gene Expression Regulation; Genes, Immediate-Early; Glutamic Acid; Immediate-Early Proteins; Kainic Acid; Membrane Potentials; N-Methylaspartate; Nerve Tissue Proteins; Neurotoxins; Oligodendroglia; Rats; Receptors, Glutamate; Stem Cells; Transcription Factors | 1994 |
Kainic acid stimulates uptake of divalent cations in postnatal cochlear neurons.
Topics: Animals; Cations, Divalent; Cobalt; Cochlea; Cricetinae; Dose-Response Relationship, Drug; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Organ Culture Techniques; Quinoxalines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate | 1994 |
A subtype of the metabotropic glutamate receptor family in the olfactory system of Atlantic salmon.
Topics: Animals; Aspartic Acid; Blotting, Northern; Brain; Cell Membrane; DNA Probes; Glutamic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kainic Acid; N-Methylaspartate; Nucleic Acid Hybridization; Olfactory Mucosa; Rats; Receptors, Metabotropic Glutamate; Salmon; Taurocholic Acid; Type C Phospholipases | 1994 |
Kainate-induced inactivation of NMDA currents via an elevation of intracellular Ca2+ in hippocampal neurons.
Topics: Animals; Animals, Newborn; Calcium; Calcium Channels; Cells, Cultured; Cytosol; Hippocampus; Intracellular Fluid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1994 |
Effect of excitatory amino acid receptor agonists on secretion of growth hormone as assessed by the reverse hemolytic plaque assay.
Topics: Amino Acids; Animals; Glutamic Acid; Growth Hormone; Growth Hormone-Releasing Hormone; Hemolytic Plaque Technique; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Somatostatin | 1994 |
Cortical neurons containing calretinin are selectively resistant to calcium overload and excitotoxicity in vitro.
Topics: Animals; Buffers; Calbindin 2; Calcimycin; Calcium; Cell Death; Cells, Cultured; Drug Resistance; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Neurotoxins; Rats; S100 Calcium Binding Protein G; Visual Cortex | 1994 |
Modulation of AMPA/kainate receptors in cultured murine hippocampal neurones by protein kinase C.
Topics: Animals; Cells, Cultured; Electric Conductivity; Ethers, Cyclic; Hippocampus; Kainic Acid; Mice; N-Methylaspartate; Neurons; Okadaic Acid; Osmolar Concentration; Protein Kinase C; Receptors, AMPA; Receptors, Kainic Acid; Synapses; Synaptic Transmission | 1994 |
NMDA and non-NMDA receptors mediating nociceptive and non-nociceptive transmission in spinal cord of cat.
Topics: Animals; Cats; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; Kainic Acid; Male; N-Methylaspartate; Nerve Fibers; Neurons; Nociceptors; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tibial Nerve | 1993 |
N-acetylaspartylglutamate selectively inhibits neuronal responses to N-methyl-D-aspartic acid in vitro.
Topics: Animals; Aspartic Acid; Canavan Disease; Cell Survival; Cells, Cultured; Cerebellum; Culture Media; Dipeptides; Kainic Acid; Mice; Mice, Inbred BALB C; N-Methylaspartate; Neurons | 1994 |
Regulation of D-aspartate release by glutamate and GABA receptors in cerebral cortical slices from developing and ageing mice.
Topics: Aging; Animals; Aspartic Acid; Cerebellum; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Kainic Acid; Male; Mice; N-Methylaspartate; Quisqualic Acid; Receptors, GABA; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Taurine | 1994 |
Morphine modulates excitatory amino acid-induced activity in the mouse spinal cord: short-term effects on N-methyl-D-aspartate (NMDA) and long-term effects on kainic acid.
Topics: Analysis of Variance; Animals; Drug Synergism; Injections, Intraperitoneal; Injections, Spinal; Kainic Acid; Male; Mice; Morphine; N-Methylaspartate; Naloxone; Spinal Cord; Stereotyped Behavior; Time Factors | 1994 |
Dipyridamole increases oxygen-glucose deprivation-induced injury in cortical cell culture.
Topics: Adenosine; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Dipyridamole; Glucose; Glutamates; Hypoxia, Brain; Kainic Acid; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Neuroglia; Neurons; Theophylline | 1994 |
The effects of neurotransmitters on the integrative properties of spinal neurons in the lamprey.
Topics: Amino Acids; Animals; Data Interpretation, Statistical; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Lampreys; Membrane Potentials; Models, Neurological; N-Methylaspartate; Neurons; Neurotransmitter Agents; Quisqualic Acid; Spinal Cord; Synapses | 1993 |
The effects of intrathecal administration of excitatory amino acid agonists and antagonists on the initiation of locomotion in the adult cat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Cats; Decerebrate State; Electromyography; Glutamates; Glutamic Acid; Hindlimb; Injections, Spinal; Kainic Acid; Laminectomy; Locomotion; Motor Activity; Muscles; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Spinal Cord; Time Factors | 1993 |
Glutamate neurotoxicity: a role for non-N-methyl-D-aspartate receptors?
Topics: Animals; Brain; Cells, Cultured; Choline O-Acetyltransferase; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Somatostatin | 1993 |
Optical imaging of parallel fiber activation in the rat cerebellar cortex: spatial effects of excitatory amino acids.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cerebellar Cortex; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Nerve Fibers; Quisqualic Acid; Rats; Rats, Sprague-Dawley | 1993 |
Involvement of excitatory amino acids in the activity of swallowing-related neurons of the ventro-lateral medulla.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Decerebrate State; Deglutition; Dipeptides; Electric Stimulation; Kainic Acid; Male; Medulla Oblongata; N-Methylaspartate; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid | 1993 |
Effect of excitatory amino acid on the hypothalamo-pituitary-adrenal axis in the rat during the stress-hyporesponsive period.
Topics: 2-Amino-5-phosphonovalerate; Adrenocorticotropic Hormone; Amino Acids; Animals; Corticosterone; Corticotropin-Releasing Hormone; Hypothalamo-Hypophyseal System; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Pituitary-Adrenal System; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Stress, Physiological | 1993 |
The triggering of spreading depression in the chicken retina: a pharmacological study.
Topics: Adenosine; Amino Acids; Animals; Baclofen; Calcium Channel Blockers; Chickens; Depression, Chemical; Excitatory Amino Acid Antagonists; Eye Enucleation; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Potassium; Quisqualic Acid; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Retina | 1993 |
In vivo regulation of extracellular dopamine in the neostriatum: influence of impulse activity and local excitatory amino acids.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biological Transport; Corpus Striatum; Dialysis; Dopamine; Exocytosis; Extracellular Space; Kainic Acid; Kynurenic Acid; Microchemistry; Models, Neurological; N-Methylaspartate; Nerve Endings; Neurotoxins; Prosencephalon; Quinoxalines; Rats; Substantia Nigra; Tetrodotoxin | 1993 |
Lateral tegmental field involvement in the central sympathoinhibitory action of 8-OH-DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Pressure; Cats; Clonidine; Denervation; Electric Stimulation; Glutamates; Glutamic Acid; Kainic Acid; Microinjections; N-Methylaspartate; Neurons; Pressoreceptors; Sympatholytics; Tegmentum Mesencephali | 1993 |
MK-801 and phencyclidine act at phencyclidine sites that are not linked to N-methyl-D-aspartate activity to inhibit behavioral sensitization to kainate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Capsaicin; Dizocilpine Maleate; Haloperidol; Kainic Acid; Male; Mice; N-Methylaspartate; Nociceptors; Phencyclidine; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Receptors, sigma; Spinal Cord | 1993 |
Electrophysiological characterization of excitatory amino acid responses in rat lateral parabrachial neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electrophysiology; Evoked Potentials; In Vitro Techniques; Kainic Acid; Kinetics; Magnesium; Male; N-Methylaspartate; Neurons; Pons; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Serine; Time Factors | 1993 |
Long-term GABA treatment elicits supersensitivity of quisqualate-preferring metabotropic glutamate receptor in cultured rat cerebellar neurons.
Topics: Animals; Baclofen; Carbachol; Cells, Cultured; Cerebellum; Drug Tolerance; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Potassium Chloride; Pyridazines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glutamate | 1993 |
High-affinity kainate binding sites in living slices of rat neocortex: characterization and regulation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Age Factors; Animals; Binding, Competitive; Cerebral Cortex; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Male; N-Methylaspartate; Nerve Tissue Proteins; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Kainic Acid; Veratridine | 1993 |
Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzothiadiazines; Cell Line; Cells, Cultured; Diazoxide; Diuretics; Electric Stimulation; Evoked Potentials; Hippocampus; Humans; Kainic Acid; Membrane Potentials; Molecular Structure; N-Methylaspartate; Neurons; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Structure-Activity Relationship; Synapses; Time Factors | 1993 |
Glutamate-induced increases in intracellular free Mg2+ in cultured cortical neurons.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Fluorescent Dyes; Fura-2; Glutamates; Glutamic Acid; Glycine; Kainic Acid; Kinetics; Magnesium; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Veratridine | 1993 |
Analysis of L-[3H]-glutamate radioligand binding to plasma membranes of the ampullae of Lorenzini of skates.
Topics: Animals; Cations; Cell Membrane; Electrophysiology; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Receptors, Glutamate; Skates, Fish; Synaptic Membranes | 1993 |
Characteristics of [3H]glutamate binding sites in rat cerebellum.
Topics: Animals; Binding Sites; Binding, Competitive; Cerebellum; Glutamates; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Species Specificity; Synaptic Membranes | 1993 |
Contribution of spinal N-methyl-D-aspartic acid receptors to control of sympathetic outflow by the paraventricular nucleus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Electric Stimulation; Heart Rate; Injections, Spinal; Kainic Acid; Kidney; N-Methylaspartate; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Renal Circulation; Spinal Cord; Sympathetic Nervous System | 1993 |
Effect of acute alcohol withdrawal on sensitivity to pro- and anticonvulsant treatments in WSP mice.
Topics: Alcohol Withdrawal Delirium; Animals; Anticonvulsants; Arousal; Convulsants; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Handling, Psychological; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Differential control of glucoregulatory hormone response and glucose metabolism by NMDA and kainate.
Topics: Adrenergic Antagonists; Animals; Blood Pressure; Corticosterone; Glucagon; Glucose; Glycogen; Heart Rate; Insulin; Insulin Secretion; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Stress, Physiological | 1994 |
Central NMDA enhances hepatic glucose output and non-insulin-mediated glucose uptake by a nonadrenergic mechanism.
Topics: Animals; Blood Pressure; Glucose; Heart Rate; Hormones; Injections, Intraventricular; Insulin; Kainic Acid; Liver; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Stress, Physiological | 1994 |
Regulation of gonadotropin-releasing hormone gene expression by the excitatory amino acids kainic acid and N-methyl-D,L-aspartate in the male rat.
Topics: Animals; Cell Nucleus; Cytoplasm; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Kainic Acid; Luteinizing Hormone; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; RNA, Heterogeneous Nuclear; RNA, Messenger | 1994 |
Effects of the epileptogenic agent bicuculline methiodide on membrane currents induced by N-methyl-D-aspartate and kainate (oocyte; Xenopus laevis).
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Electric Conductivity; Epilepsy; Kainic Acid; N-Methylaspartate; Oocytes; Xenopus laevis | 1994 |
Cytosolic calcium transient increase through the AMPA/kainate receptor in cultured Müller cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Cytosol; Glutamates; Kainic Acid; N-Methylaspartate; Potassium; Rabbits; Receptors, AMPA; Receptors, Kainic Acid; Retina; Spectrometry, Fluorescence | 1994 |
Effect of kainic acid and NMDA on the pattern electroretinogram, the scotopic threshold response, the oscillatory potentials and the electroretinogram in the urethane anaesthetized cat.
Topics: Animals; Cats; Dark Adaptation; Depression, Chemical; Dose-Response Relationship, Drug; Electroretinography; Evoked Potentials, Visual; Kainic Acid; N-Methylaspartate; Pattern Recognition, Visual; Retina; Sensory Thresholds | 1994 |
Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo.
Topics: Animals; Dopamine; Electrophysiology; Iontophoresis; Kainic Acid; Male; Mesencephalon; N-Methylaspartate; Neurons; Neurotoxins; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Selective excitotoxic pathology in the rat hippocampus.
Topics: Animals; Brain; Brain Damage, Chronic; Cell Death; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Organ Specificity; Piperazines; Quisqualic Acid; Rats; Rats, Sprague-Dawley | 1993 |
Altered luteinizing hormone and prolactin responses to excitatory amino acids during lactation.
Topics: Amino Acids; Animals; Estrus; Female; Injections, Intravenous; Injections, Intraventricular; Kainic Acid; Lactation; Luteinizing Hormone; Mifepristone; N-Methylaspartate; Progesterone; Prolactin; Rats; Rats, Sprague-Dawley | 1993 |
Processing of photic information within the intergeniculate leaflet of the lateral geniculate body: assessed by neuropeptide Y immunoreactivity in the suprachiasmatic nucleus of rats.
Topics: Animals; Circadian Rhythm; Dizocilpine Maleate; Geniculate Bodies; Hypothalamus; Kainic Acid; Male; N-Methylaspartate; Neural Pathways; Neuropeptide Y; Photic Stimulation; Rats; Rats, Wistar; Suprachiasmatic Nucleus; Time Factors | 1993 |
The hypoglycemic sulphonylurea tolbutamide increases N-methyl-D-aspartate- but not kainate-activated currents in hippocampal neurons in culture.
Topics: Animals; Binding Sites; Cells, Cultured; Electrophysiology; Glycine; Hippocampus; Kainic Acid; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Tolbutamide | 1993 |
Maximum discharge rates of respiratory neurons during opossum development.
Topics: Action Potentials; Animals; Animals, Suckling; Axons; Kainic Acid; Medulla Oblongata; Myelin Sheath; N-Methylaspartate; Neurons; Opossums; Respiratory Center | 1993 |
Muscarinic potentiation of excitatory amino acid-evoked dopamine release in mesencephalic cells: specificity for the NMDA response and role of intracellular messengers.
Topics: Alkaloids; Animals; Carbachol; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dopamine; Drug Synergism; Fetus; Isoquinolines; Kainic Acid; Kinetics; Mesencephalon; N-Methylaspartate; Neurons; Oxotremorine; Protein Kinase C; Quisqualic Acid; Rats; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems; Staurosporine | 1993 |
Blockade of retinal NMDA receptors by sodium nitroprusside is probably due to nitric oxide formation.
Topics: Animals; Female; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Nitric Oxide; Nitroprusside; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Retina | 1993 |
Acute, chronic and differential effects of several anesthetic barbiturates on glutamate receptor activation in neuronal culture.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; Cyproheptadine; Glutamates; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Pentobarbital; Potassium Chloride; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Secobarbital; Thiamylal | 1993 |
Excitatory and inhibitory pathways modulate kainate excitotoxicity in hippocampal slice cultures.
Topics: Animals; Animals, Newborn; Hippocampus; Kainic Acid; N-Methylaspartate; Nerve Fibers; Neural Pathways; Neurons; Organ Culture Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Synapses | 1993 |
Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus.
Topics: Aging; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cerebral Ventricles; Dizocilpine Maleate; Gene Expression; Hippocampus; In Situ Hybridization; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neurotrophin 3; Pilocarpine; Pyramidal Tracts; Rats; Rats, Wistar; RNA Probes; RNA, Messenger; Scopolamine; Transcription, Genetic | 1993 |
Interleukin-2 modulates evoked release of [3H]dopamine in rat cultured mesencephalic cells.
Topics: Animals; Cells, Cultured; Dopamine; gamma-Aminobutyric Acid; Interleukin-2; Kainic Acid; Mesencephalon; N-Methylaspartate; Potassium; Rats; Tritium | 1993 |
Enkephalin suppresses afferent cochlear neurotransmission.
Topics: Animals; Cochlea; Dendrites; Enkephalins; Guinea Pigs; Hair Cells, Auditory, Inner; Kainic Acid; N-Methylaspartate; Naloxone; Neurons, Afferent; Neurons, Efferent; Quisqualic Acid; Synaptic Transmission | 1993 |
Chronic ethanol intoxication induces differential effects on GABAA and NMDA receptor function in the rat brain.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Convulsants; Dizocilpine Maleate; Ethanol; Isoniazid; Kainic Acid; Male; Membrane Proteins; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Seizures; Synaptic Transmission | 1993 |
Use-dependent pentobarbital block of kainate and quisqualate currents.
Topics: Animals; Cells, Cultured; Evoked Potentials; Kainic Acid; N-Methylaspartate; Neurons; Pentobarbital; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Kainic Acid | 1993 |
Glutathione modulates the N-methyl-D-aspartate receptor-activated calcium influx into cultured rat cerebellar granule cells.
Topics: Animals; Biological Transport; Calcium; Cells, Cultured; Cerebellum; Cysteine; Dithiothreitol; Glutathione; Glutathione Disulfide; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1993 |
L-arginine potentiates excitatory amino acid-induced seizures elicited in the deep prepiriform cortex.
Topics: Animals; Arginine; Brain; Drug Synergism; Electroencephalography; Kainic Acid; Male; Microinjections; N-Methylaspartate; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar; Seizures; Stereoisomerism | 1993 |
Ionotropic glutamate receptor subtypes activate c-fos transcription by distinct calcium-requiring intracellular signaling pathways.
Topics: Animals; Calcium; Calmodulin; Cyclooxygenase Inhibitors; Genes, fos; Hippocampus; Imidazoles; In Situ Hybridization; Kainic Acid; N-Methylaspartate; Neurons; Phospholipases A; Phospholipases A2; Protein Kinases; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Signal Transduction; Transcription, Genetic | 1993 |
The distribution of excitatory amino acid receptors on acutely dissociated dorsal horn neurons from postnatal rats.
Topics: Animals; Animals, Newborn; Dendrites; Electrophysiology; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Potassium; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Spinal Cord | 1993 |
Relationship between resting cytosolic Ca2+ and responses induced by N-methyl-D-aspartate in hippocampal neurons.
Topics: Animals; Calcium; Cells, Cultured; Cytosol; Embryo, Mammalian; Fura-2; Hippocampus; Kainic Acid; Kinetics; Membrane Potentials; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Potassium Chloride; Rats | 1993 |
High-dose ketamine does not induce c-Fos protein expression in rat hippocampus.
Topics: Amygdala; Animals; Behavior, Animal; Cerebral Cortex; Hippocampus; Immunohistochemistry; In Vitro Techniques; Kainic Acid; Ketamine; Male; N-Methylaspartate; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Seizures; Thalamus | 1993 |
Cardiovascular responses to global cerebral ischemia: role of excitatory amino acids in the ventrolateral medullary pressor area.
Topics: Acetylcholine; Amino Acids; Animals; Antidiuretic Hormone Receptor Antagonists; Atropine; Blood Pressure; Brain Ischemia; Dose-Response Relationship, Drug; Glutamates; Heart Rate; Kainic Acid; Kynurenic Acid; Male; Medulla Oblongata; Muscimol; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Vasopressin; Vasopressins | 1993 |
Modulation of the seizure threshold for excitatory amino acids in mice by antiepileptic drugs and chemoconvulsants.
Topics: Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Drug Administration Routes; Isoxazoles; Kainic Acid; Male; Mice; N-Methylaspartate; Propionates; Receptors, Glutamate; Seizures | 1993 |
Spectrin proteolysis in the hippocampus: a biochemical marker for neuronal injury and neuroprotection.
Topics: Animals; Biomarkers; Calpain; Carbazoles; Cell Death; Dizocilpine Maleate; Enzyme Activation; Female; Hippocampus; Indole Alkaloids; Kainic Acid; Male; N-Methylaspartate; Neurons; Neurotoxins; Protein Kinase C; Rats; Rats, Sprague-Dawley; Spectrin | 1993 |
Characterization of the glutamate receptors mediating release of somatostatin from cultured hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cells, Cultured; Cycloleucine; Dizocilpine Maleate; Drug Synergism; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Somatostatin; Tetrodotoxin | 1996 |
Inhibition by propofol (2,6 di-isopropylphenol) of the N-methyl-D-aspartate subtype of glutamate receptor in cultured hippocampal neurones.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Patch-Clamp Techniques; Propofol; Receptors, N-Methyl-D-Aspartate | 1995 |
Stimulation of serotonin release in the rat brain cortex by activation of ionotropic glutamate receptors and its modulation via alpha 2-heteroreceptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Glutamate; Serotonin | 1995 |
Excitatory amino acid-induced currents in rat septal cholinergic neurons in culture.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cholinergic Fibers; Excitatory Amino Acids; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Septal Nuclei; Zinc | 1995 |
Structure-activity relationships in a series of 2(1H)-quinolones bearing different acidic function in the 3-position: 6,7-dichloro-2(1H)-oxoquinoline-3-phosphonic acid, a new potent and selective AMPA/kainate antagonist with neuroprotective properties.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Brain Ischemia; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gerbillinae; Kainic Acid; Mice; Molecular Structure; N-Methylaspartate; Neuroprotective Agents; Organophosphonates; Quinolones; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Xenopus | 1996 |
Excitatory amino acid induced currents of isolated murine hypothalamic neurons and their suppression by 2,3-butanedione monoxime.
Topics: Animals; Cholinesterase Reactivators; Diacetyl; Excitatory Amino Acids; Glutamic Acid; Hypothalamus; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred Strains; N-Methylaspartate; Patch-Clamp Techniques | 1995 |
Direct in vivo comparison of two mechanisms releasing dopamine in the rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Cadmium; Corpus Striatum; Dopamine; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Time Factors | 1995 |
Regulation of N-methyl-D-aspartate-induced toxicity in the neostriatum: a role for metabotropic glutamate receptors?
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apomorphine; Cyclopentanes; GABA Agonists; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Microscopy, Video; Motor Activity; N-Methylaspartate; Neostriatum; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reference Values | 1996 |
The effects of (-)- and (+)-beta-cyclazocine on NMDA-evoked responses and NMDA-mediated cell damage in cultured rat hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Survival; Cells, Cultured; Cyclazocine; Kainic Acid; Microchemistry; N-Methylaspartate; Neuroprotective Agents; Potassium; Pyramidal Cells; Rats; Rats, Wistar; Spectrometry, Fluorescence; Stereoisomerism | 1995 |
Glutamate receptor agonists modulate [Ca2+]i in isolated rat melanotropes.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Fluorescent Dyes; Fura-2; Glutamic Acid; Glycine; Kainic Acid; Magnesium; Male; N-Methylaspartate; Pituitary Gland; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate | 1995 |
Effects of repeated cold stress on aversive responses produced by intrathecal excitatory amino acids in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cold Temperature; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Stress, Psychological | 1995 |
In vivo electrochemical studies of the dynamic effects of locally applied excitatory amino acids in the striatum of the anesthetized rat.
Topics: Adolescent; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Cricetinae; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acids; Glutamic Acid; Humans; Kainic Acid; Male; N-Methylaspartate; Oxidation-Reduction; Potassium; Quinolinic Acid; Quisqualic Acid; Rats; Rats, Sprague-Dawley | 1996 |
Effects of inhalation anesthetics of Kainate-induced glutamate release from cerebellar granule cells.
Topics: Anesthetics, Inhalation; Animals; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Drug Interactions; Glutamic Acid; Kainic Acid; Kinetics; N-Methylaspartate; Neurons, Afferent; Rats; Rats, Sprague-Dawley | 1996 |
Effects of decahydroisoquinoline-3-carboxylic acid monohydrate, a novel AMPA receptor antagonist, on glutamate-induced CA2+ responses and neurotoxicity in rat cortical and cerebellar granule neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cerebellum; Cerebral Cortex; Dose-Response Relationship, Drug; Glutamic Acid; Isoquinolines; Kainic Acid; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tetrazoles | 1995 |
Functional glutamate receptors in a subpopulation of anterior pituitary cells.
Topics: Animals; Calcium; Corticotropin-Releasing Hormone; Glutamic Acid; Gonadotropin-Releasing Hormone; Growth Hormone-Releasing Hormone; Kainic Acid; Male; N-Methylaspartate; Pituitary Gland, Anterior; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Thyrotropin-Releasing Hormone | 1996 |
Characterization of excitatory amino acid modulation of dopamine release in the prefrontal cortex of conscious rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Consciousness; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Microdialysis; N-Methylaspartate; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 1996 |
Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Behavior, Animal; Brain; Brain Diseases, Metabolic; Endopeptidases; Excitatory Amino Acid Agonists; Hyperkinesis; Kainic Acid; Mice; Mice, Transgenic; Mutation; N-Methylaspartate; Neurons; Protein Processing, Post-Translational; Seizures | 1996 |
Decreased gonadotropin-releasing hormone neurosecretory response to glutamate agonists in middle-aged female rats on proestrus afternoon: a possible role in reproductive aging?
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arcuate Nucleus of Hypothalamus; Base Sequence; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Gonadotropin-Releasing Hormone; Kainic Acid; Luteinizing Hormone; Median Eminence; Molecular Sequence Data; N-Methylaspartate; Preoptic Area; Proestrus; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1996 |
A primary acoustic startle pathway: obligatory role of cochlear root neurons and the nucleus reticularis pontis caudalis.
Topics: Action Potentials; Animals; Auditory Pathways; Cochlear Nerve; Cochlear Nucleus; Electric Stimulation; Evoked Potentials, Auditory; Excitatory Amino Acid Agonists; Kainic Acid; Male; Motor Neurons; N-Methylaspartate; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Reflex, Startle; Reticular Formation | 1996 |
Excitatory amino acid-induced neuronal cell death in rat cerebellar granule cell cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Cells, Cultured; Cerebellum; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate | 1995 |
Septal and hippocampal glutamate receptors modulate the output of acetylcholine in hippocampus: a microdialysis study.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Male; Microdialysis; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Receptors, Glutamate; Septal Nuclei | 1996 |
Structure-activity studies of 6-(tetrazolylalkyl)-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 1. Effects of stereochemistry, chain length, and chain substitution.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carboxylic Acids; Cerebral Cortex; Isoquinolines; Kainic Acid; Kinetics; Molecular Structure; N-Methylaspartate; Pipecolic Acids; Radioligand Assay; Rats; Receptors, AMPA; Structure-Activity Relationship; Tetrazoles; Tritium | 1996 |
Pentobarbital differentially inhibits N-methyl-D-aspartate and kainate-stimulated [3H]noradrenaline overflow in rat cortical slices.
Topics: Adrenergic alpha-Agonists; Animals; Excitatory Amino Acid Agonists; GABA Modulators; Kainic Acid; Male; N-Methylaspartate; Norepinephrine; Pentobarbital; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 1995 |
Effects of felbamate, kynurenic acid derivatives and NMDA antagonists on in vitro kainate-induced epileptiform activity.
Topics: Animals; Anticonvulsants; Excitatory Amino Acid Antagonists; Felbamate; Hippocampus; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Neuroprotective Agents; Phenylcarbamates; Propylene Glycols; Rats; Rats, Wistar | 1996 |
Responses mediated by excitatory and inhibitory amino acid receptors in solitary spiking cells from normal newt retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Dose-Response Relationship, Drug; Glutamic Acid; Kainic Acid; N-Methylaspartate; Patch-Clamp Techniques; Receptors, Amino Acid; Retina; Salamandridae | 1995 |
Development of responses to excitatory and inhibitory amino acids in spiking cells during retinal regeneration in the adult newt.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Kainic Acid; N-Methylaspartate; Patch-Clamp Techniques; Receptors, Amino Acid; Regeneration; Retina; Salamandridae; Strychnine | 1995 |
DCG-IV selectively attenuates rapidly triggered NMDA-induced neurotoxicity in cortical neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bucladesine; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cyclopropanes; Glycine; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Neurotoxins; Pertussis Toxin; Receptors, Metabotropic Glutamate; Virulence Factors, Bordetella | 1996 |
Mechanisms for synchronous calcium oscillations in cultured rat cerebellar neurons.
Topics: Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Cells, Cultured; Cerebellum; Enzyme Inhibitors; Ionomycin; Kainic Acid; Kinetics; Magnesium; Membrane Potentials; N-Methylaspartate; Neuroglia; Neurons; Oscillometry; Quisqualic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Thapsigargin; Time Factors | 1996 |
Peripheral administration of NMDA, AMPA or KA results in pain behaviors in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Excitatory Amino Acid Antagonists; Hindlimb; Kainic Acid; Logistic Models; Male; N-Methylaspartate; Pain; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1996 |
Glutamate receptor ion channel properties predict vulnerability to cytotoxicity in a transfected nonneuronal cell line.
Topics: 2-Amino-5-phosphonovalerate; Animals; Base Sequence; Benzothiadiazines; Cell Line; Cell Survival; Concanavalin A; Dizocilpine Maleate; DNA Primers; Evoked Potentials; Glutamic Acid; Humans; Ion Channels; Kainic Acid; Kidney; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylaspartate; Neurotoxins; Patch-Clamp Techniques; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Transfection | 1996 |
Actions of long chain alcohols on GABAA and glutamate receptors: relation to in vivo effects.
Topics: Alcohols; Animals; Cerebral Cortex; Humans; Kainic Acid; Mice; N-Methylaspartate; Receptors, GABA-A; Receptors, Glutamate; Recombinant Proteins; RNA, Messenger; Xenopus | 1996 |
L-Glutamate-induced responses in OFF-type bipolar cells of the cat retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Calcium; Cats; Chlorides; Cycloleucine; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; In Vitro Techniques; Ion Transport; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Potassium; Retina; Retinal Cone Photoreceptor Cells; Sodium | 1996 |
Kainate, GABAA and NMDA receptors in Xenopus oocytes expressing mRNA from the cortex of mice kindled with FG 7142.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Oocytes; Receptors, GABA-A; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1996 |
Polyamine amides are neuroprotective in cerebellar granule cell cultures challenged with excitatory amino acids.
Topics: Amides; Animals; Arthropod Venoms; Calcium; Cells, Cultured; Cerebellum; Excitatory Amino Acid Agonists; Glutamic Acid; Indoleacetic Acids; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Phenols; Phenylacetates; Polyamines; Potassium; Rats; Rats, Wistar; Spider Venoms | 1996 |
Glutamate release evoked by glutamate receptor agonists in cultured chick retina cells: modulation by arachidonic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Benzofurans; Calcium Chloride; Cells, Cultured; Chick Embryo; Ethers, Cyclic; Excitatory Amino Acid Agonists; Fluorescent Dyes; Glutamic Acid; Indoles; Kainic Acid; Kinetics; N-Methylaspartate; Receptors, Glutamate; Retina; Sodium; Spectrometry, Fluorescence | 1996 |
The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits.
Topics: Animals; Cerebral Cortex; Female; Glutamic Acid; Glycine; Kainic Acid; Macromolecular Substances; Membrane Potentials; N-Methylaspartate; Nerve Tissue Proteins; Oocytes; Polymerase Chain Reaction; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA, Messenger; Xenopus laevis | 1996 |
Kainate produces concentration-dependent elevation of glutamate release but not cGMP levels in cultured neuron.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Kainic Acid; N-Methylaspartate; Neurons; Neurotoxins; Piperazines; Quinoxalines | 1996 |
Ca(2+)-permeable AMPA/kainate and NMDA channels: high rate of Ca2+ influx underlies potent induction of injury.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Intracellular Membranes; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Nerve Degeneration; Osmolar Concentration; Permeability; Time Factors | 1996 |
Effects of excitatory amino acids on phosphoinositide metabolism in frog retina.
Topics: Animals; Carbachol; Excitatory Amino Acid Agonists; In Vitro Techniques; Kainic Acid; Microscopy, Electron; N-Methylaspartate; Phosphatidylinositols; Quisqualic Acid; Ranidae; Retina | 1996 |
[Ca2+]i regulation by glutamate receptor agonists in cultured chick retina cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cells, Cultured; Chick Embryo; Excitatory Amino Acid Agonists; Inositol Phosphates; Kainic Acid; N-Methylaspartate; Retina; Stimulation, Chemical | 1996 |
Potentiation and inhibition of ionotropic neurotransmitter receptors expressed in Xenopus oocyte by linoleic acid and its hydroperoxide.
Topics: Animals; Drug Synergism; Electrophysiology; Female; gamma-Aminobutyric Acid; Kainic Acid; Linoleic Acid; Linoleic Acids; Male; N-Methylaspartate; Oocytes; Rats; Rats, Wistar; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Xenopus | 1996 |
Lateral hypothalamic NMDA receptors and glutamate as physiological mediators of eating and weight control.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Body Weight; Circadian Rhythm; Eating; Excitatory Amino Acid Antagonists; Food Deprivation; Glutamic Acid; Hypothalamic Area, Lateral; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 1996 |
Opposite effects of TGF-beta 1 on rapidly- and slowly-triggered excitotoxic injury.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; N-Methylaspartate; Neurons; Purkinje Cells; Rats; Time Factors; Transforming Growth Factor beta | 1996 |
Interaction between striatal excitatory amino acid and gamma-aminobutyric acid (GABA) receptors in the turning behaviour of rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Caudate Nucleus; Data Interpretation, Statistical; Excitatory Amino Acid Agonists; GABA Antagonists; GABA-A Receptor Antagonists; Kainic Acid; Male; N-Methylaspartate; Neostriatum; Picrotoxin; Putamen; Rats; Rats, Wistar; Receptors, GABA; Receptors, Glutamate | 1995 |
A patch clamp study of the effects of ciprofloxacin and biphenyl acetic acid on rat hippocampal neurone GABAA and ionotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Bicuculline; Cells, Cultured; Ciprofloxacin; Drug Interactions; Hippocampus; Kainic Acid; N-Methylaspartate; Patch-Clamp Techniques; Phenylacetates; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glutamate | 1995 |
Requirement for superoxide in excitotoxic cell death.
Topics: Aconitate Hydratase; Animals; Biomarkers; Cell Death; Cells, Cultured; Cerebral Cortex; Enzyme Activation; Kainic Acid; Metalloporphyrins; N-Methylaspartate; Neurons; Neurotoxins; Paraquat; Rats; Rats, Sprague-Dawley; Superoxides | 1996 |
Ca2+ influx through glutamate receptor-associated channels in retina cells correlates with neuronal cell death.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Calcium Channels; Cell Death; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neuroprotective Agents; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Retina | 1996 |
Potentiation of excitatory amino acid-evoked adenosine release from rat cortex by inhibitors of adenosine kinase and adenosine deaminase and by acadesine.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminoimidazole Carboxamide; Animals; Cerebral Cortex; Drug Synergism; Excitatory Amino Acid Agonists; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Ribonucleosides | 1996 |
Effects of excitatory amino acids on the hypothalamic-pituitary-adrenal axis of the neonatal rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenocorticotropic Hormone; Age Factors; Animals; Animals, Newborn; Behavior, Animal; Corticosterone; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hypothalamo-Hypophyseal System; Kainic Acid; Male; N-Methylaspartate; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Stress, Physiological; Time Factors | 1996 |
Developmental changes in glutamate receptor-activated translocation of protein kinase C in cerebellar granule neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Biological Transport; Carcinogens; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurotoxins; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Tritium | 1996 |
Excitoprotective effect of felbamate in cultured cortical neurons.
Topics: Animals; Anticonvulsants; Binding Sites; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Felbamate; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Phenylcarbamates; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Strychnine | 1995 |
Glutamate receptor-induced toxicity in neostriatal cells.
Topics: Animals; Cell Size; Excitatory Amino Acid Agonists; In Vitro Techniques; Kainic Acid; Male; Microscopy, Video; N-Methylaspartate; Neostriatum; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1996 |
Metabotropic glutamate receptor activation selectively limits excitotoxic damage in the intact neostriatum.
Topics: Analysis of Variance; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Kainic Acid; Male; Microinjections; N-Methylaspartate; Neostriatum; Neuroprotective Agents; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1996 |
Glutamate receptor-mediated calcium entry in neurons derived from P19 embryonal carcinoma cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Line; Cytosol; Electrophysiology; Embryonal Carcinoma Stem Cells; Excitatory Amino Acid Agonists; Glycine; Immunohistochemistry; Ion Channel Gating; Kainic Acid; Mice; N-Methylaspartate; Neoplastic Stem Cells; Neurons; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1996 |
The vulnerability of spinal cord neurons to excitotoxic injury: comparison with cortical neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebral Cortex; Cobalt; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Spinal Cord; Staining and Labeling; Time Factors | 1996 |
Hemoglobin potentiates excitotoxic injury in cortical cell culture.
Topics: Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Antioxidants; Brain Injuries; Cells, Cultured; Cerebral Cortex; Chromans; Deferoxamine; Drug Synergism; Excitatory Amino Acids; Hemoglobin A; Humans; Kainic Acid; Kinetics; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Neuroglia; Neurons | 1996 |
Evidence that excitatory amino acids mediate afferent input to the primate somatosensory thalamus.
Topics: Afferent Pathways; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acids; Kainic Acid; Macaca; Male; Membrane Potentials; N-Methylaspartate; Thalamus | 1996 |
A role for synaptic and network plasticity in controlling epileptiform activity in CA1 in the kainic acid-lesioned rat hippocampus in vitro.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neuronal Plasticity; Rats; Rats, Wistar; Synaptic Transmission | 1996 |
In vitro autoradiography of ionotropic glutamate receptors in hippocampus and striatum of aged Long-Evans rats: relationship to spatial learning.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; Kainic Acid; Male; Maze Learning; N-Methylaspartate; Organ Specificity; Prosencephalon; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Regression Analysis; Tritium | 1996 |
Involvement of nitric oxide in spinally mediated capsaicin- and glutamate-induced behavioural responses in the mouse.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Receptors, Tachykinin; Spinal Cord | 1996 |
Effect of glutamate receptor ligands on mitochondrial membrane potential in rat dissociated cerebellar cells.
Topics: Animals; Animals, Newborn; Calcium; Cerebellum; Fluorescent Dyes; Glutamic Acid; In Vitro Techniques; Kainic Acid; Ligands; Membrane Potentials; Mitochondria; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Rhodamine 123; Rhodamines; Sodium; Spectrometry, Fluorescence | 1996 |
Noninvasive assessment of the relative roles of cerebral antioxidant enzymes by quantitation of pentose phosphate pathway activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbon Isotopes; Caudate Nucleus; Cells, Cultured; Cerebral Cortex; Deferoxamine; Deuterium; Dizocilpine Maleate; Fetus; Gas Chromatography-Mass Spectrometry; Glucose; Hydrogen Peroxide; Iron; Kainic Acid; Kinetics; N-Methylaspartate; Neuroglia; Neurons; Pentose Phosphate Pathway; Putamen; Quinoxalines; Rats | 1996 |
Imaging NMDA- and kainate-induced intrinsic optical signals from the hippocampal slice.
Topics: Animals; Computer Systems; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurotoxins; Optics and Photonics; Rats; Rats, Sprague-Dawley; Signal Processing, Computer-Assisted; Temperature; Video Recording; Vision, Ocular | 1996 |
Effects of alcohols and food additives on glutamate receptors expressed in Xenopus oocytes: specificity in the inhibition of the receptors.
Topics: Alcohols; Animals; Electrophysiology; Excitatory Amino Acid Antagonists; Female; Food Additives; Kainic Acid; N-Methylaspartate; Oocytes; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sensitivity and Specificity; Xenopus laevis | 1996 |
Concentration of putrescine in plasma, frontal cortex and hippocampus of rats after systemic administration of the convulsants N-methyl-D-aspartate, pentylentetrazol, picrotoxinine, lindane and 4-aminopyridine.
Topics: Aminopyrine; Analysis of Variance; Animals; Convulsants; Drug Evaluation, Preclinical; Evaluation Studies as Topic; Excitatory Amino Acid Agonists; Frontal Lobe; Hexachlorocyclohexane; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Putrescine; Rats; Rats, Wistar; Sesterterpenes | 1996 |
Tachycardia after glutamate injection in rat spinal cord is not blocked by kynurenate or mimicked by metabotropic agonists.
Topics: Aminobutyrates; Analysis of Variance; Animals; Blood Pressure; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Injections, Spinal; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred WKY; Receptors, Metabotropic Glutamate; Spinal Cord; Tachycardia | 1996 |
Biphasic effect of taurine on excitatory amino acid-induced neurotoxicity.
Topics: Animals; Brain; Cells, Cultured; Excitatory Amino Acid Agonists; Fetus; Glutamic Acid; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Taurine | 1996 |
Regulation of dopamine uptake in rat striatal tissue by NMDA receptors as measured using rotating disk electrode voltammetry.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dopamine; Dopamine Antagonists; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kainic Acid; Kinetics; Male; N-Methylaspartate; Neostriatum; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic | 1996 |
Differential effects of the N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors of the excitatory amino acids system on LH and FSH secretion. Its effects on the hypothalamic luteinizing hormone releasing hormone during maturation in male rats.
Topics: Animals; Excitatory Amino Acid Agonists; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Hypothalamus; In Vitro Techniques; Kainic Acid; Luteinizing Hormone; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1996 |
Effects of N-methyl-D-aspartate and kainic acid on prolactin secretion in prepubertal female rats.
Topics: Aging; Animals; Dopamine; Enzyme Inhibitors; Female; Kainic Acid; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Pituitary Gland; Prolactin; Rats; Rats, Wistar; Serotonin; Sexual Maturation | 1996 |
Potentiation of spontaneous acetylcholine release from motor nerve terminals by glutamate in Xenopus tadpoles.
Topics: Acetylcholine; Alanine; Animals; Calcium; Calcium Channel Blockers; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Larva; Motor Endplate; N-Methylaspartate; Neurotoxins; Quisqualic Acid; Second Messenger Systems; Verapamil; Xenopus laevis | 1996 |
Systemic L-kynurenine administration partially protects against NMDA, but not kainate-induced degeneration of retinal ganglion cells, and reduces visual discrimination deficits in adults rats.
Topics: Animals; Behavior, Animal; Biological Transport; Cell Count; Cell Death; Excitatory Amino Acid Agonists; Horseradish Peroxidase; Image Processing, Computer-Assisted; Kainic Acid; Kynurenine; Light; N-Methylaspartate; Rats; Retinal Degeneration; Retinal Ganglion Cells; Vision Disorders; Visual Perception | 1996 |
Glutamate as a putative neurotransmitter in the mollusc, Lymnaea stagnalis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanosine Diphosphate; Kainic Acid; Lymnaea; Membrane Potentials; N-Methylaspartate; Nervous System Physiological Phenomena; Neurons; Neuropeptides; Neurotransmitter Agents; Patch-Clamp Techniques; Quisqualic Acid; Synapses; Thionucleotides | 1996 |
Rapid attenuation of AP-1 transcriptional factors associated with nitric oxide (NO)-mediated neuronal cell death.
Topics: Animals; Apoptosis; Calcium; Catalase; Cells, Cultured; Ferrocyanides; Kainic Acid; Mice; N-Methylaspartate; Neurons; Nitric Oxide; Nitroprusside; Proto-Oncogene Proteins c-fos; Receptors, Glutamate; RNA, Messenger; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 1996 |
Excitatory amino acid regulation of astrocyte proteoglycans.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; CD57 Antigens; Cell Membrane; Cells, Cultured; Chondroitin Sulfates; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Heparitin Sulfate; Hippocampus; Immunohistochemistry; Kainic Acid; N-Methylaspartate; Protein Kinase C; Rats; Receptors, Metabotropic Glutamate; Subcellular Fractions; Sulfates; Sulfur Radioisotopes | 1996 |
Effect of alpha-MSH upon cyclic AMP levels induced by the glutamatergic agonists NMDA, quisqualic acid, and kainic acid.
Topics: alpha-MSH; Animals; Caudate Nucleus; Cyclic AMP; Drug Interactions; Excitatory Amino Acid Agonists; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Nucleus Accumbens; Putamen; Quisqualic Acid; Rats; Rats, Wistar | 1996 |
NMDA and non-NMDA receptors mediate taste afferent inputs to cortical taste neurons in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cerebral Cortex; Electrophysiology; Excitatory Amino Acid Antagonists; Kainic Acid; N-Methylaspartate; Neurons; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical; Taste | 1995 |
Dopamine enhancement and depression of glutamate-regulated calcium and electrical activity in hypothalamic neurons.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Dopamine; Excitatory Amino Acid Agonists; Fluorescent Dyes; Fura-2; Glutamic Acid; Hypothalamus; Kainic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tetrodotoxin | 1996 |
mu-Opioid receptors modulate NMDA receptor-mediated responses in nucleus accumbens neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Agonists; Kainic Acid; Male; N-Methylaspartate; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Synapses; Synaptic Transmission | 1997 |
Regulation of voltage- and ligand-gated currents in rat hippocampal progenitor cells in vitro.
Topics: Animals; Antibody Specificity; Brain-Derived Neurotrophic Factor; Calcium Channels; Cell Differentiation; Cell Division; Cells, Cultured; Electrophysiology; Excitatory Amino Acid Agonists; Fibroblast Growth Factors; gamma-Aminobutyric Acid; Hippocampus; Immunohistochemistry; Ion Channel Gating; Kainic Acid; Ligands; N-Methylaspartate; Nerve Growth Factors; Neurons; Neurotrophin 3; Rats; Sodium; Stem Cells; tau Proteins | 1997 |
NMDA and kainate-evoked release of nitric oxide and classical transmitters in the rat striatum: in vivo evidence that nitric oxide may play a neuroprotective role.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Kainic Acid; Male; N-Methylaspartate; Neuroprotective Agents; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Synthase; Penicillamine; Potassium Chloride; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine | 1996 |
Differential effects of excitatory amino acids on mesencephalic neurons expressing either calretinin or tyrosine hydroxylase in primary cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calbindin 2; Cell Survival; Cells, Cultured; Excitatory Amino Acids; Kainic Acid; Mesencephalon; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Phenotype; Rats; S100 Calcium Binding Protein G; Tyrosine 3-Monooxygenase | 1996 |
Release of [3H]dopamine from striatal and cerebral cortical slices from rats with thioacetamide-induced hepatic encephalopathy: different responses to stimulation by potassium ions and agonists of ionotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Agonists; Hepatic Encephalopathy; Kainic Acid; Male; N-Methylaspartate; Potassium; Rats; Rats, Wistar; Receptors, Glutamate; Thioacetamide; Tritium | 1997 |
An electrophysiological study of neurons in the horizontal limb of the diagonal band of Broca.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Frontal Lobe; Kainic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tetrodotoxin | 1997 |
Glutamate and N-methyl-D-aspartate stimulate rat hypothalamic corticotropin-releasing factor secretion in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corticotropin-Releasing Hormone; Culture Techniques; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Hypothalamus; Kainic Acid; Male; N-Methylaspartate; Potassium Chloride; Rats; Rats, Wistar | 1997 |
Calretinin-containing neurons in rat cerebellar granule cell cultures.
Topics: Animals; Calbindin 2; Calcium; Cells, Cultured; Cerebellum; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Rats; Rats, Sprague-Dawley; Ribonucleases; RNA, Messenger; S100 Calcium Binding Protein G | 1997 |
Effects of glutamate receptor agonists and antagonists on Ca2+ uptake in rat hippocampal slices lesioned by glucose deprivation or by kainate.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glucose; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Neuroprotective Agents; Organ Culture Techniques; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate; Synaptic Transmission | 1997 |
Competitive antagonism of recombinant AMPA/kainate receptors by N-methyl-D-aspartate and analogues.
Topics: Animals; Benzothiadiazines; Binding, Competitive; Diuretics; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; N-Methylaspartate; Rats; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Sodium Chloride Symporter Inhibitors; Xenopus laevis | 1996 |
Extrasynaptic glutamate spillover in the hippocampus: dependence on temperature and the role of active glutamate uptake.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport, Active; Diffusion; Electric Stimulation; Evoked Potentials; Glutamates; Guinea Pigs; Hippocampus; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Temperature | 1997 |
Hippocampal N-methyl-D-aspartate and kainate binding in response to entorhinal cortex aspiration or 192 IgG-saporin lesions of the basal forebrain.
Topics: Acetylcholinesterase; Aging; Animals; Antibodies, Monoclonal; Cholinergic Agents; Entorhinal Cortex; Glutamic Acid; Hippocampus; Immunotoxins; Kainic Acid; Kinetics; Male; N-Glycosyl Hydrolases; N-Methylaspartate; Neurons; Prosencephalon; Pyramidal Tracts; Radioligand Assay; Rats; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Ribosome Inactivating Proteins, Type 1; Saporins; Tritium | 1997 |
A new non-NMDA antagonist modifies the local cerebral glucose utilization in kainate-induced generalized seizure.
Topics: Animals; Anticonvulsants; Brain; Dizocilpine Maleate; Glucose; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
Evidence that the early loss of membrane protein kinase C is a necessary step in the excitatory amino acid-induced death of primary cortical neurons.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzophenanthridines; Calcium; Carcinogens; Cell Death; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Fetus; Gene Expression; Glutamic Acid; Kainic Acid; Membrane Proteins; N-Methylaspartate; Naphthalenes; Neurons; Phenanthridines; Potassium Chloride; Pregnancy; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Effect of glutamate receptor phosphorylation by endogenous protein kinases on electrical activity of isolated postsynaptic densities of rat cortex and hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; Animals; Calcium; Calmodulin; Cerebral Cortex; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Kainic Acid; Long-Term Potentiation; Magnesium; N-Methylaspartate; Patch-Clamp Techniques; Phosphorylation; Protein Kinases; Quisqualic Acid; Rats; Receptors, Glutamate; Synapses | 1997 |
Functional organization of cone bipolar cells in the rat retina.
Topics: Animals; Evoked Potentials; Excitatory Amino Acid Agonists; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neural Conduction; Neurons; Patch-Clamp Techniques; Rats; Reaction Time; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Retinal Cone Photoreceptor Cells; Subcellular Fractions | 1997 |
Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice.
Topics: Animals; Anticonvulsants; Clonazepam; Desoxycorticosterone; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Isomerism; Kainic Acid; Male; Mice; Muscarinic Agonists; N-Methylaspartate; Pilocarpine; Progesterone; Seizures; Status Epilepticus; Steroids | 1996 |
Unilateral eyeball enucleation differentially alters AMPA-, NMDA- and kainate glutamate receptor binding in the newborn rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Autoradiography; Brain; Eye Enucleation; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Visual Cortex | 1996 |
Spontaneous bursting activity of dopaminergic neurons in midbrain slices from immature rats: role of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; Dopamine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Male; Mesencephalon; N-Methylaspartate; Neurons; Periodicity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Specific [3H]glutamate binding in the cerebral cortex and hippocampus of rats during development: effect of homocysteine-induced seizures.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Binding Sites; Cerebral Cortex; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Reference Values; Seizures; Synaptic Membranes; Tritium | 1997 |
Regulation of cerebral microvessels by glutamatergic mechanisms.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Cerebrovascular Circulation; Cycloleucine; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Microcirculation; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synapses; Vasoconstriction; Vasodilation | 1997 |
Interaction of cholecystokinin and glutamate agonists within the dLGN, the dentate gyrus, and the hippocampus.
Topics: Animals; Dentate Gyrus; Drug Interactions; Excitatory Amino Acid Agonists; Geniculate Bodies; Hippocampus; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Sincalide; Statistics, Nonparametric | 1996 |
Glutamate receptor agonists evoked Ca(2+)-dependent and Ca(2+)-independent release of [3H]D-aspartate from cultured chick retina cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Calcium; Cells, Cultured; Chickens; Excitatory Amino Acid Agonists; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Potassium Chloride; Receptors, Glutamate; Retina; Tritium | 1996 |
Induction of TRE and CRE binding activities in cultured granule cells stimulated via glutamate receptors.
Topics: Animals; Binding Sites; Cells, Cultured; Cerebellum; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Kainic Acid; Mice; N-Methylaspartate; Neurons; Nuclear Proteins; Protein Kinase C; Pyramidal Cells; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Regulatory Factor X Transcription Factors; Transcription Factors | 1993 |
Buckminsterfullerenol free radical scavengers reduce excitotoxic and apoptotic death of cultured cortical neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antioxidants; Apoptosis; Carbon; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; Electron Spin Resonance Spectroscopy; Excitatory Amino Acid Agonists; Free Radical Scavengers; Fullerenes; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Patch-Clamp Techniques; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1996 |
Cortical neurones exhibiting kainate-activated Co2+ uptake are selectively vulnerable to AMPA/kainate receptor-mediated toxicity.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Cobalt; Excitatory Amino Acid Agonists; Kainic Acid; Mice; N-Methylaspartate; Receptors, AMPA; Receptors, Kainic Acid | 1994 |
Bipotent progenitor cell lines from the human CNS.
Topics: Astrocytes; Brain; Brain-Derived Neurotrophic Factor; Bucladesine; Cell Culture Techniques; Cell Differentiation; Cell Line; Cell Line, Transformed; Fetus; gamma-Aminobutyric Acid; Genes, myc; Gestational Age; Glycine; Humans; Kainic Acid; Membrane Potentials; Models, Neurological; N-Methylaspartate; Neurons; Oncogene Protein p55(v-myc); Recombinant Proteins; Stem Cells; Transfection | 1997 |
Induction of tumor suppressor p53 and DNA fragmentation in organotypic hippocampal cultures following excitotoxin treatment.
Topics: Animals; Autoradiography; Cell Death; Dentate Gyrus; DNA Fragmentation; Excitatory Amino Acid Agonists; Gene Expression Regulation; In Situ Hybridization; Kainic Acid; Mammals; N-Methylaspartate; Neurotoxins; Organ Culture Techniques; Pyramidal Cells; RNA, Messenger; Time Factors; Tumor Suppressor Protein p53 | 1997 |
Estimation of the relative potency of two glycine antagonists on NMDA-induced depolarizations in BRSC and ARCS.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Potassium Chloride; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission | 1997 |
Role of histidyl residues in the binding of ligands to the porcine N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Cerebral Cortex; Diethyl Pyrocarbonate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Histidine; Ionophores; Kainic Acid; Ligands; N-Methylaspartate; Piperazines; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Swine; Synaptic Membranes; Tritium | 1997 |
Association of c-fos mRNA expression and excitotoxicity in primary cultures of mouse neocortical and cerebellar neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Cells, Cultured; Cerebellar Cortex; Cerebral Cortex; Cysteine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Genes, fos; Glutamic Acid; Kainic Acid; Mice; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Proto-Oncogene Proteins c-fos; RNA, Messenger | 1997 |
Intracellular Ca2+ imaging of cultured chicken telencephalic cells: characterization of ionotropic glutamate receptor activation.
Topics: Animals; Calcium; Cells, Cultured; Chick Embryo; Fluorescent Dyes; Fura-2; Intracellular Membranes; Kainic Acid; Microscopy, Phase-Contrast; N-Methylaspartate; Neurons; Receptors, Glutamate; Telencephalon | 1996 |
Influences of excitatory amino acid receptor agonists on nucleus of the solitary tract neurons receiving aortic depressor nerve inputs.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aorta; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Nervous System Physiological Phenomena; Neurons; Rats; Rats, Sprague-Dawley; Solitary Nucleus | 1997 |
NMDA receptor coagonist glycine site: evidence for a role in lateral hypothalamic stimulation of feeding.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Eating; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hypothalamic Area, Lateral; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Binding Sites; Corpus Striatum; Dizocilpine Maleate; DNA Fragmentation; Excitatory Amino Acid Antagonists; Hydroxyl Radical; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Nitric Oxide Synthase; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Tyrosine | 1997 |
NMDA-mediated facilitation in the echo-delay tuned areas of the auditory cortex of the mustached bat.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Action Potentials; Animals; Auditory Cortex; Chiroptera; Echolocation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Iontophoresis; Kainic Acid; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate | 1997 |
Neuronal nitric oxide synthase and calmodulin-dependent protein kinase IIalpha undergo neurotoxin-induced proteolysis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calpain; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Fetus; Kainic Acid; Kinetics; Marine Toxins; N-Methylaspartate; Neurons; Neurotoxins; Nitric Oxide Synthase; Okadaic Acid; Oxocins; Rats; Rats, Sprague-Dawley; Spectrin | 1997 |
Effects of newly developed excitatory amino acid antagonists on vestibular type I neurons in the cat.
Topics: Animals; Azepines; Cats; Decerebrate State; Dose-Response Relationship, Drug; Electrodes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Injections, Intravenous; Iontophoresis; Kainic Acid; Muscle Relaxants, Central; N-Methylaspartate; Neuromuscular Junction; Neurons; Neurotransmitter Agents; Oxazoles; Oxazolidinones; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Rotation; Vestibular Nerve; Vestibular Nuclei | 1997 |
The GABAA receptor is expressed in human neurons derived from a teratocarcinoma cell line.
Topics: Bicuculline; Cell Differentiation; Electric Conductivity; Evoked Potentials; gamma-Aminobutyric Acid; Humans; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Receptors, GABA-A; Sodium Channels; Teratocarcinoma; Tetrodotoxin; Tretinoin; Tumor Cells, Cultured | 1997 |
Bioisosterically modified dipeptide excitatory amino acid receptor antagonists containing 3-oxygenated isothiazole ring systems.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cerebral Cortex; Corpus Callosum; Dipeptides; Electrophysiology; Excitatory Amino Acid Antagonists; Kainic Acid; Models, Chemical; N-Methylaspartate; Piperazines; Rats; Receptors, AMPA; Stereoisomerism | 1997 |
Excitotoxicity in the enteric nervous system.
Topics: Animals; Antibody Specificity; Apoptosis; Cells, Cultured; Enteric Nervous System; Excitatory Amino Acid Agonists; Ganglia; Glutamic Acid; Guinea Pigs; Kainic Acid; Male; Membrane Potentials; Mitochondria; N-Methylaspartate; Necrosis; Neurites; Neurons; Neurotoxins; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 1997 |
Effect of excitatory amino acids on rat hypothalamic somatostatin secretion in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Hypothalamus; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Potassium Chloride; Rats; Rats, Wistar; Receptors, Glutamate; Somatostatin | 1997 |
Kainate excitotoxicity is mediated by AMPA- but not kainate-preferring receptors in embryonic rat hippocampal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Culture Media, Conditioned; Embryo, Mammalian; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Neurotoxins; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid | 1997 |
Riluzole blocks dopamine release evoked by N-methyl-D-aspartate, kainate, and veratridine in the rat striatum.
Topics: Animals; Corpus Striatum; Dopamine; Kainic Acid; Male; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Riluzole; Veratridine | 1997 |
Glutamate stimulates 2-deoxyglucose uptake in rat cerebellar granule cells.
Topics: Animals; Cerebellum; Deoxyglucose; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Phosphorylation; Quisqualic Acid; Rats; Rats, Wistar; Temperature | 1997 |
Differential expression of Egr-1-like DNA-binding activities in the naive rat brain and after excitatory stimulation.
Topics: Animals; Behavior, Animal; Binding, Competitive; Brain; Consensus Sequence; DNA-Binding Proteins; Early Growth Response Protein 1; Immediate-Early Proteins; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Tissue Distribution; Transcription Factors | 1997 |
Release of dopamine, GABA and EAA in rats during intrastriatal perfusion with kainic acid, NMDA and soman: a comparative microdialysis study.
Topics: Animals; Cholinesterase Inhibitors; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Injections, Intraventricular; Kainic Acid; Male; Microdialysis; Motor Activity; N-Methylaspartate; Neostriatum; Rats; Rats, Wistar; Soman | 1997 |
Measurement of intracellular free zinc in living cortical neurons: routes of entry.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Biological Transport; Calcimycin; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Fura-2; Ionophores; Kainic Acid; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Neocortex; Neurons; Nimodipine; Quinoxalines; Sodium-Calcium Exchanger; Zinc | 1997 |
Modulation of nicotinic ACh-, GABAA- and 5-HT3-receptor functions by external H-7, a protein kinase inhibitor, in rat sensory neurones.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Adenosine Triphosphate; Allosteric Regulation; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; gamma-Aminobutyric Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons, Afferent; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Nicotinic; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Second Messenger Systems; Serotonin | 1997 |
Intracellular free Ca2+ elevations in cultured astroglia induced by neuroligands playing a role in cerebral ischemia.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Astrocytes; Brain Ischemia; Calcium; Cells, Cultured; Cytoplasm; Excitatory Amino Acid Agonists; Extracellular Space; Fluorescent Dyes; Fura-2; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Quisqualic Acid; Rats; Receptors, Glutamate; Serotonin; Spectrometry, Fluorescence; Vasoconstrictor Agents; Vasopressins | 1997 |
Impairment of brain kynurenic acid production by glutamate metabotropic receptor agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Cycloleucine; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Sodium | 1997 |
Neuroprotective effect of dapsone against quinolinate- and kainate-induced striatal neurotoxicities in rats.
Topics: Animals; Behavior, Animal; Brain Chemistry; Corpus Striatum; Dapsone; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Kainic Acid; Male; N-Methylaspartate; Neuroprotective Agents; Quinolinic Acid; Rats; Rats, Wistar | 1997 |
Breathing of awake goats during prolonged dysfunction of caudal M ventrolateral medullary neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbon Dioxide; Cold Temperature; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Goats; Kainic Acid; Male; Medulla Oblongata; N-Methylaspartate; Neurons; Neurotoxins; Receptors, N-Methyl-D-Aspartate; Respiratory Mechanics | 1998 |
Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzoates; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Kinetics; Motor Neurons; N-Methylaspartate; Neuroprotective Agents; Rats; Spinal Cord | 1997 |
Aspartate as a selective NMDA receptor agonist in cultured cells from the avian retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Retina | 1998 |
The involvement of metabotropic glutamate receptors in sensory transmission in dorsal horn of the rat spinal cord.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Agonists; Extracellular Space; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Nerve Fibers; Neurons, Afferent; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord; Synaptic Transmission | 1998 |
Endogenous opioid peptides acting at mu-opioid receptors in the dorsal horn contribute to midbrain modulation of spinal nociceptive neurons.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Bicuculline; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Agonists; GABA Antagonists; Hot Temperature; Iontophoresis; Kainic Acid; Male; Medulla Oblongata; N-Methylaspartate; Naloxone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Peptide Fragments; Peptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Tail | 1998 |
Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Survival; Cells, Cultured; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; N-Methylaspartate; Neurons; Rats; Time Factors | 1998 |
Taurine release from the developing and ageing hippocampus: stimulation by agonists of ionotropic glutamate receptors.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Female; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; N-Methylaspartate; Receptors, Glutamate; Taurine | 1997 |
Responses to N-methyl-D-aspartate and kainic acid in cerebellar granule cells of lead-exposed rat pups.
Topics: Administration, Oral; Animals; Animals, Newborn; Cells, Cultured; Cerebellum; Female; Kainic Acid; Lead; Maternal Exposure; Maternal-Fetal Exchange; N-Methylaspartate; Pregnancy; Rats | 1998 |
Synapse-specific accumulation of lithium in intracellular microdomains: a model for uncoupling coincidence detection in the brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Computer Simulation; Electric Conductivity; Electrophysiology; Extracellular Space; Female; Intracellular Membranes; Kainic Acid; Lithium; Models, Neurological; N-Methylaspartate; Neural Conduction; Neurons; Oocytes; Permeability; Substrate Specificity; Synapses; Xenopus | 1998 |
Fenamates protect neurons against ischemic and excitotoxic injury in chick embryo retina.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flufenamic Acid; Glucose; Kainic Acid; Meclofenamic Acid; Mefenamic Acid; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; ortho-Aminobenzoates; Oxygen; Patch-Clamp Techniques; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells | 1998 |
Evidence that functional glutamate receptors are not expressed on rat or human cerebromicrovascular endothelial cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Calcium; Capillaries; Cattle; Cells, Cultured; Cerebrovascular Circulation; Colforsin; Cyclic AMP; Cycloleucine; Endothelin-1; Endothelium, Vascular; Gene Expression; Humans; Inositol 1,4,5-Trisphosphate; Kainic Acid; Mice; N-Methylaspartate; Neurons; Polymerase Chain Reaction; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Second Messenger Systems | 1998 |
Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons.
Topics: Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Intracellular Fluid; Kainic Acid; N-Methylaspartate; Neurons; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Sodium-Calcium Exchanger; Thiourea | 1998 |
Mitochondrial transmembrane potential and free radical production in excitotoxic neurodegeneration.
Topics: Animals; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Membrane Potentials; Mitochondria; N-Methylaspartate; Neurons; Rats; Rats, Inbred F344; Superoxides | 1998 |
Potassium channel activators protect the N-methyl-D-aspartate-induced cerebral vascular dilation after combined hypoxia and ischemia in piglets.
Topics: Analysis of Variance; Animals; Animals, Newborn; Benzimidazoles; Calcitonin Gene-Related Peptide; Female; Hypoxia, Brain; Ischemic Attack, Transient; Kainic Acid; Male; N-Methylaspartate; Papaverine; Picolines; Potassium Channels; Pyrans; Swine; Vasodilator Agents | 1998 |
NMDA- and MK801-induced changes in dopamine release are attenuated in kainic acid-lesioned nucleus accumbens of conscious rats: an in vivo microdialysis study.
Topics: Animals; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Microdialysis; N-Methylaspartate; Nucleus Accumbens; Rats; Rats, Wistar | 1998 |
Prenatal ethanol exposure enhances glutamate release stimulated by quisqualate in rat cerebellar granule cell cultures.
Topics: Alcoholism; Amino Acids; Animals; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Ethanol; Female; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Potassium Chloride; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1998 |
The transcription factor NF-kappaB mediates increases in calcium currents and decreases in NMDA- and AMPA/kainate-induced currents induced by tumor necrosis factor-alpha in hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Electric Conductivity; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; N-Methylaspartate; Neurons; NF-kappa B; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 1998 |
Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Injections, Intraperitoneal; Injections, Intraventricular; Kainic Acid; Male; Melatonin; Mice; Mice, Inbred C57BL; Motor Activity; N-Methylaspartate; Pentylenetetrazole; Quinolinic Acid; Seizures | 1998 |
Effects of N-methyl-D-aspartic acid and kainic acid on prolactin secretion in hyper- and hypoprolactinaemic conditions.
Topics: alpha-Methyltyrosine; Animals; Animals, Newborn; Enzyme Inhibitors; Estradiol; Female; Hyperprolactinemia; Kainic Acid; N-Methylaspartate; Ovariectomy; Ovary; Prolactin; Rats; Rats, Wistar; Secretory Rate; Testosterone; Tyrosine 3-Monooxygenase | 1998 |
Striatal spiny neurons and cholinergic interneurons express differential ionotropic glutamatergic responses and vulnerability: implications for ischemia and Huntington's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Cholinergic Fibers; Corpus Striatum; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Huntington Disease; Interneurons; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurotoxins; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1998 |
Chlormethiazole anticonvulsive efficacy diminished by N-methyl-D-aspartate but not kainate in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Chlormethiazole; Electroshock; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Mice; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Seizures | 1998 |
Facilitation of responses to AMPA but not kainate by cyclothiazide in primate somatosensory thalamus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Drug Synergism; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Macaca fascicularis; Male; N-Methylaspartate; Thalamic Nuclei | 1998 |
Excitatory amino acid-induced degeneration of dendrites of catecholamine neurons in rat substantia nigra.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Catecholamines; Dendrites; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1998 |
Effect of glutamate receptor agonists on catecholamine secretion in bovine chromaffin cells.
Topics: Adrenal Medulla; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Nicotine; Receptors, Glutamate | 1998 |
Evidence for activation of caspase-3-like protease in excitotoxin- and hypoxia/hypoglycemia-injured neurons.
Topics: Animals; Caspase 3; Caspases; Cell Death; Cell Hypoxia; Cells, Cultured; Cerebellum; Cerebral Cortex; Cysteine Endopeptidases; Enzyme Precursors; Excitatory Amino Acid Agonists; Fetus; Glucose; Hypoglycemia; Kainic Acid; N-Methylaspartate; Neurons; Neurotoxins; Oligopeptides; Peptide Fragments; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Spectrin | 1998 |
Binding characteristics of a potent AMPA receptor antagonist [3H]Ro 48-8587 in rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Brain Chemistry; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Imidazoles; In Situ Hybridization; Kainic Acid; Kinetics; Male; N-Methylaspartate; Quinazolines; Quinoxalines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, AMPA; RNA, Messenger; Tritium | 1998 |
The effect of excitatory aminoacids on GABA release from mediobasal hypothalamus of female rats.
Topics: Animals; Depression, Chemical; Diestrus; Drug Implants; Estradiol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hypothalamus; Interneurons; Kainic Acid; N-Methylaspartate; Nerve Tissue Proteins; Nitric Oxide Synthase; Ovariectomy; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1998 |
Characterization of temperature rise of the brain and the rectum following intracerebroventricular administration of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and kainate in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Non-Narcotic; Animals; Body Temperature; Brain; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Indomethacin; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Rectum | 1998 |
BDNF gene transcripts in mesencephalic neurons and its differential regulation by NMDA.
Topics: Animals; Blotting, Southern; Brain-Derived Neurotrophic Factor; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Kainic Acid; Mesencephalon; N-Methylaspartate; Neurons; Polymerase Chain Reaction; Pregnancy; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; RNA, Messenger; Transcription, Genetic | 1998 |
Changes in GluR4 expression induced by metabotropic receptor activation in radial glia cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Chick Embryo; Cycloleucine; Glutamic Acid; Kainic Acid; Kinetics; N-Methylaspartate; Neuroglia; Polymerase Chain Reaction; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Metabotropic Glutamate; Retina; RNA, Messenger; Transcription, Genetic; Up-Regulation | 1998 |
Regulation of NMDA-induced [3H]dopamine release from rat hippocampal slices through sigma-1 binding sites.
Topics: Animals; Binding Sites; Dopamine; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Pentazocine; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, sigma; Sigma-1 Receptor; Tetrodotoxin; Tritium | 1998 |
Characterization of neuroprotection from excitotoxicity by moderate and profound hypothermia in cultured cortical neurons unmasks a temperature-insensitive component of glutamate neurotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Cold Temperature; Cycloleucine; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Fluorescent Dyes; Glutamic Acid; Humans; Hypothermia, Induced; Kainic Acid; Mice; N-Methylaspartate; Neuroglia; Neurons; Neurotoxins; Synapses | 1998 |
Selective modulation of GABAA receptors by aluminum.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aluminum; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; N-Methylaspartate; Neurons, Afferent; Olfactory Bulb; Patch-Clamp Techniques; Rats; Receptors, GABA-A; Receptors, Glutamate; Smell | 1998 |
Low-affinity kainate receptors and long-lasting depression of NMDA-receptor-mediated currents in rat superficial dorsal horn.
Topics: Action Potentials; Animals; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Glutamic Acid; Indoles; Ion Channel Gating; Kainic Acid; Male; N-Methylaspartate; Neurons, Afferent; Neuroprotective Agents; Oximes; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Nerve Roots; Synaptic Transmission | 1998 |
Role of excitatory amino acid pathways in control of gonadotrophin secretion in adult female rats sterilized by neonatal administration of oestradiol or testosterone.
Topics: Animals; Animals, Newborn; Anovulation; Dizocilpine Maleate; Estradiol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Female; Follicle Stimulating Hormone; Gonadotropins, Pituitary; Kainic Acid; Luteinizing Hormone; N-Methylaspartate; Ovariectomy; Quinoxalines; Rats; Rats, Wistar; Testosterone | 1998 |
Bilateral intranigral NMDA infusion suppresses neuronal injury without affecting the duration of kainic acid-induced seizures in rats.
Topics: Animals; Blood Pressure; Functional Laterality; Heat-Shock Proteins; Hippocampus; HSP72 Heat-Shock Proteins; Infusions, Parenteral; Kainic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Substantia Nigra | 1998 |
Differential roles for NMDA and non-NMDA receptor subtypes in baroreceptor afferent integration in the nucleus of the solitary tract of the rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons, Afferent; Phenylephrine; Pressoreceptors; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Solitary Nucleus; Synapses; Vasoconstrictor Agents | 1998 |
Gene transfer of calbindin D28k cDNA via herpes simplex virus amplicon vector decreases cytoplasmic calcium ion response and enhances neuronal survival following glutamatergic challenge but not following cyanide.
Topics: Animals; Calbindin 1; Calbindins; Calcium; Cell Survival; Cells, Cultured; Cytoplasm; DNA, Complementary; Fluorometry; Gene Transfer Techniques; Genetic Vectors; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Plasmids; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G; Simplexvirus; Sodium Cyanide | 1998 |
Rapid Ca2+ entry through Ca2+-permeable AMPA/Kainate channels triggers marked intracellular Ca2+ rises and consequent oxygen radical production.
Topics: Animals; Calcium; Calcium Channels; Cells, Cultured; Excitatory Amino Acid Agonists; Extracellular Space; Fluorescent Dyes; Fura-2; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Ion Channel Gating; Kainic Acid; Mice; Mitochondria; N-Methylaspartate; Neocortex; Neurons; Potassium; Reactive Oxygen Species; Receptors, AMPA; Receptors, Kainic Acid | 1998 |
Evidence that excitatory amino acid receptors within the temporomandibular joint region are involved in the reflex activation of the jaw muscles.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Brain Stem; Dose-Response Relationship, Drug; Electromyography; Evans Blue; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Jaw; Kainic Acid; Lidocaine; Male; Masseter Muscle; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Reflex; Temporomandibular Joint; Trigeminal Nerve | 1998 |
Allosteric regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptors by thiocyanate and cyclothiazide at a common modulatory site distinct from that of 2,3-benzodiazepines.
Topics: Allosteric Regulation; Animals; Anti-Anxiety Agents; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Binding Sites; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Hippocampus; Ion Channel Gating; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Oocytes; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Thiocyanates; Xenopus | 1998 |
Calcium influx via ionotropic glutamate receptors causes long lasting inhibition of metabotropic glutamate receptor-coupled phosphoinositide hydrolysis.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GTP-Binding Proteins; Hydrolysis; Kainic Acid; N-Methylaspartate; Phosphatidylinositols; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Sodium Fluoride | 1998 |
Dihydrokainate-sensitive neuronal glutamate transport is required for protection of rat cortical neurons in culture against synaptically released glutamate.
Topics: Animals; Biological Transport; Calcium; Calcium Radioisotopes; Cell Survival; Cells, Cultured; Cerebral Cortex; Dicarboxylic Acids; Extracellular Space; Fetus; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Tetrodotoxin | 1998 |
Mossy fibre innervation is not required for the development of kainic acid toxicity in organotypic hippocampal slice cultures.
Topics: Animals; Cell Death; Cell Survival; Hippocampus; In Vitro Techniques; Kainic Acid; Microelectrodes; Mossy Fibers, Hippocampal; N-Methylaspartate; Neural Pathways; Pyramidal Cells; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate; Time Factors; Valine | 1998 |
The neuronal death induced by endotoxic shock but not that induced by excitatory amino acids requires TNF-alpha.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Death; Enzyme Activation; Excitatory Amino Acids; Free Radicals; Hippocampus; Interferon-gamma; Kainic Acid; Lipopolysaccharides; Microglia; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neurons; Nitric Oxide; Organ Culture Techniques; p38 Mitogen-Activated Protein Kinases; Rats; Reactive Oxygen Species; Receptors, Glutamate; Shock, Septic; Tumor Necrosis Factor-alpha | 1998 |
Amyloid beta-protein impairs astrocyte-mediated differentiation of hippocampal neurons.
Topics: Amyloid beta-Peptides; Animals; Astrocytes; Calcium Signaling; Cell Differentiation; Cell Membrane; Cells, Cultured; Coculture Techniques; Electric Conductivity; Embryo, Mammalian; Fetus; gamma-Aminobutyric Acid; Glycine; Hippocampus; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Peptide Fragments; Rats; Time Factors | 1998 |
Glutamatergic and GABAergic agonists increase [Ca2+]i in avian cochlear nucleus neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Chick Embryo; Cochlear Nucleus; Excitatory Amino Acid Agonists; Fluorescent Dyes; Fura-2; GABA Agonists; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Stimulation, Chemical | 1998 |
NMDA and AMPA receptors evoke transmitter release from noradrenergic axon terminals in the rat spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Concanavalin A; Dizocilpine Maleate; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Norepinephrine; Presynaptic Terminals; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tetrodotoxin | 1998 |
Dopaminergic modulation of early signs of excitotoxicity in visualized rat neostriatal neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Cell Size; Dopamine; Dopamine Agonists; Dopamine Antagonists; Excitatory Amino Acid Agonists; In Vitro Techniques; Kainic Acid; Microscopy, Video; N-Methylaspartate; Neostriatum; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1998 |
Reduced mitochondrial manganese-superoxide dismutase activity exacerbates glutamate toxicity in cultured mouse cortical neurons.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Glutamic Acid; Homozygote; Kainic Acid; Mice; Mice, Knockout; Mitochondria; N-Methylaspartate; Neurons; Oxidation-Reduction; Quisqualic Acid; Superoxide Dismutase | 1998 |
Conformational changes of the smooth endoplasmic reticulum are facilitated by L-glutamate and its receptors in rat Purkinje cells.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apnea; Bradycardia; Calcium Signaling; Cycloleucine; Dendrites; Endoplasmic Reticulum, Smooth; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia, Brain; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Nerve Tissue Proteins; Neuroprotective Agents; Purkinje Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Respiration | 1998 |
Sexual differences in the role of kainate receptors in controlling gonadotrophin secretion in prepubertal rats.
Topics: Analysis of Variance; Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Female; Follicle Stimulating Hormone; Gonadotropins, Pituitary; Kainic Acid; Luteinizing Hormone; Male; N-Methylaspartate; Orchiectomy; Ovariectomy; Quinoxalines; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Sex Factors; Sexual Maturation | 1998 |
[S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Electric Stimulation; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pyridines; Rats; Rats, Sprague-Dawley; Seizures; Seizures, Febrile; Strychnine; Time Factors; Weaning | 1999 |
Differential blood-brain barrier breakdown and leucocyte recruitment following excitotoxic lesions in juvenile and adult rats.
Topics: Aging; Animals; Astrocytes; Biomarkers; Blood-Brain Barrier; Brain; Excitatory Amino Acid Agonists; Immunoenzyme Techniques; Inflammation; Kainic Acid; Leukocytes; Male; Microglia; N-Methylaspartate; Nerve Degeneration; Permeability; Rats; Rats, Wistar; Time Factors | 1998 |
Distinct roles for sodium, chloride, and calcium in excitotoxic dendritic injury and recovery.
Topics: Animals; Brain Injuries; Bridged Bicyclo Compounds; Calcium; Cells, Cultured; Chlorides; Coculture Techniques; Cytosol; Dendrites; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Mice; Microscopy, Fluorescence; N-Methylaspartate; Quinoxalines; Receptors, Glutamate; Sodium; Veratridine | 1998 |
Plasticity- and neurodegeneration-linked cyclic-AMP responsive element modulator/inducible cyclic-AMP early repressor messenger RNA expression in the rat brain.
Topics: Animals; Brain; Cyclic AMP; Cyclic AMP Response Element Modulator; Darkness; Dizocilpine Maleate; DNA-Binding Proteins; Early Growth Response Protein 1; Female; Functional Laterality; Gene Expression Regulation; Genes, fos; Genes, jun; Hippocampus; Immediate-Early Proteins; In Situ Hybridization; Kainic Acid; Light; Male; N-Methylaspartate; Neuronal Plasticity; Photic Stimulation; Rats; Rats, Wistar; Repressor Proteins; RNA, Messenger; Transcription Factors; Transcription, Genetic | 1998 |
Stimulation with N-methyl-D-aspartate or kainic acid increases cyclic guanosine monophosphate-like immunoreactivity in turtle retina: involvement of nitric oxide synthase.
Topics: Animals; Cyclic GMP; Immunohistochemistry; Kainic Acid; N-Methylaspartate; Nitric Oxide Synthase; Receptors, Glutamate; Retina; Signal Transduction; Turtles | 1999 |
Activation of NMDA and non-NMDA receptors in the caudal ventrolateral medulla dilates the airways.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Atropine Derivatives; Autonomic Nervous System; Bronchoconstriction; Cholinergic Fibers; Dogs; Electric Stimulation; Excitatory Amino Acid Agonists; Female; Kainic Acid; Lung; Male; Medulla Oblongata; Muscle, Smooth; N-Methylaspartate; Parasympatholytics; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical | 1998 |
Glutamatergic induction of CREB phosphorylation and Fos expression in primary cultures of the suprachiasmatic hypothalamus in vitro is mediated by co-ordinate activity of NMDA and non-NMDA receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cricetinae; Cyclic AMP Response Element-Binding Protein; Dizocilpine Maleate; Gene Expression; Genes, fos; Glutamic Acid; Kainic Acid; Male; Mesocricetus; N-Methylaspartate; Phosphorylation; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Suprachiasmatic Nucleus | 1999 |
Excitotoxic death of a subset of embryonic rat motor neurons in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Calcium Channels, L-Type; Cell Culture Techniques; Cell Death; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glutamine; Glycine; Kainic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Nerve Tissue Proteins; Neurotoxins; Potassium; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Regulation of vasopressin release by ionotropic glutamate receptor agonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Hypothalamo-Hypophyseal System; Kainic Acid; N-Methylaspartate; Organ Culture Techniques; Quinoxalines; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Vasopressins | 1998 |
Effects of competitive NMDA receptor antagonists on excitatory amino acid-evoked currents in mouse spinal cord neurones.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding, Competitive; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Excitatory amino acid responses in relay neurons of the rat lateral geniculate nucleus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antihypertensive Agents; Benzothiadiazines; Concanavalin A; Dipeptides; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Geniculate Bodies; Glutamic Acid; Glycine; Ionophores; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neuroprotective Agents; Nystatin; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1999 |
Preferential Zn2+ influx through Ca2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production.
Topics: Calcium; Calcium Channels; Cells, Cultured; Embryo, Mammalian; Embryo, Nonmammalian; Kainic Acid; Membrane Potentials; Mitochondria; N-Methylaspartate; Neocortex; Neurons; Neurotoxins; Potassium; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Superoxides; Zinc | 1999 |
mGluR7-like metabotropic glutamate receptors inhibit NMDA-mediated excitotoxicity in cultured mouse cerebellar granule neurons.
Topics: Animals; Calcium Channels; Cell Death; Cells, Cultured; Cerebellum; Cyclic GMP; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Mice; Microtubule-Associated Proteins; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Patch-Clamp Techniques; Phosphoserine; Propionates; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Glutamate-, kainate- and NMDA-evoked membrane currents in identified glial cells in rat spinal cord slice.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Astrocytes; Cell Membrane; Electric Conductivity; Excitatory Amino Acid Antagonists; Glutamic Acid; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neuroglia; Oligodendroglia; Patch-Clamp Techniques; Rats; Receptors, AMPA; Receptors, Kainic Acid; Spinal Cord | 1998 |
NS-257, a novel competitive AMPA receptor antagonist, interacts with kainate and NMDA receptors.
Topics: Animals; Antihypertensive Agents; Benzothiadiazines; Concanavalin A; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Indoles; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Microinjections; N-Methylaspartate; Oocytes; Patch-Clamp Techniques; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Complementary; RNA, Messenger; Sulfonamides; Xenopus | 1999 |
Activation of excitatory amino acid receptors in bovine dental pulp evokes the release of iCGRP.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Cattle; Dental Pulp; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurogenic Inflammation; Neurons, Afferent; Nociceptors; Radioimmunoassay; Receptors, Glutamate; Statistics, Nonparametric | 1999 |
The effects of excitatory amino acids on isolated gut segments of the rat.
Topics: Animals; Aspartic Acid; Cycloleucine; Digestive System; Digestive System Physiological Phenomena; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Female; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth; N-Methylaspartate; Neuroprotective Agents; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Resistance of gonadotropin-releasing hormone neurons to glutamatergic neurotoxicity.
Topics: Animals; Brain Chemistry; Cricetinae; Excitatory Amino Acid Agonists; Gene Expression; Glutamic Acid; Gonadotropin-Releasing Hormone; In Situ Hybridization; Kainic Acid; Male; N-Methylaspartate; Neurons; Neurotoxins; Phodopus; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1998 |
Sources of reactive oxygen species production in excitotoxin- stimulated cerebellar granule cells.
Topics: Animals; Calcium; Cell Survival; Cells, Cultured; Cerebellar Cortex; Cyclooxygenase Inhibitors; Electron Transport; Flow Cytometry; Fluoresceins; Indomethacin; Kainic Acid; Monoamine Oxidase Inhibitors; N-Methylaspartate; Neurons; Neurotoxins; Nialamide; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rotenone; Tetradecanoylphorbol Acetate | 1999 |
Analyses of taste nerve responses with special reference to possible receptor mechanisms of umami taste in the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chorda Tympani Nerve; Electrophysiology; Excitatory Amino Acid Agonists; Glutamic Acid; Inosine Monophosphate; Kainic Acid; Male; N-Methylaspartate; Neurons, Afferent; Potassium; Propionates; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Taste | 1999 |
Cardiovascular responses to microinjections of excitatory amino acids into the area postrema of the rat.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Intravenous; Animals; Blood Pressure; Bradycardia; Cerebral Ventricles; Cycloleucine; Decerebrate State; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Male; Microinjections; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Wistar; Tachycardia; Urethane | 1999 |
High vulnerability of GABA-immunoreactive neurons to kainate in rat retinal cultures: correlation with the kainate-stimulated cobalt uptake.
Topics: Animals; Cell Count; Cells, Cultured; Cobalt; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Kainic Acid; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Retina | 1999 |
Properties of NMDA receptors in rat spinal cord motoneurons.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Ion Channel Gating; Kainic Acid; Kynurenic Acid; Magnesium; Male; Motor Neurons; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Ionotropic glutamate receptors in isolated horizontal cells of the rabbit retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Ion Channel Gating; Kainic Acid; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, Kainic Acid; Retina | 1999 |
Spatiotemporal patterning of glutamate receptors in developing ferret striate cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ferrets; Kainic Acid; N-Methylaspartate; Radioligand Assay; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Tritium; Visual Cortex | 1999 |
Vagally-regulated gastric motor activity: evidence for kainate and NMDA receptor mediation.
Topics: Animals; Atropine; Blood Pressure; Brain Stem; Bronchodilator Agents; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gastrointestinal Motility; Glutamic Acid; Kainic Acid; Male; Microinjections; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stomach; Vagus Nerve | 1999 |
Involvement of sigma receptors in the modulation of the glutamatergic/NMDA neurotransmission in the dopaminergic systems.
Topics: Analgesics, Opioid; Animals; Caudate Nucleus; Cinnamates; Cyclopropanes; Dopamine; Electrophysiology; Excitatory Amino Acids; Glutamic Acid; Guanidines; Kainic Acid; Male; N-Methylaspartate; Neurons; Nucleus Accumbens; Pentazocine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, sigma; Sigma-1 Receptor; Spiro Compounds; Substantia Nigra; Synaptic Transmission; Thiazoles; Ventral Tegmental Area | 1999 |
Recurrent mossy fiber pathway in rat dentate gyrus: synaptic currents evoked in presence and absence of seizure-induced growth.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Dentate Gyrus; Electric Stimulation; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Feedback; GABA Antagonists; Kainic Acid; Male; Mossy Fibers, Hippocampal; N-Methylaspartate; Organ Culture Techniques; Parasympathomimetics; Patch-Clamp Techniques; Perforant Pathway; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Staining and Labeling; Status Epilepticus; Synapses | 1999 |
Effects of 2-phenoxyethanol on N-methyl-D-aspartate (NMDA) receptor-mediated ion currents.
Topics: Anesthetics; Animals; Brain; Dose-Response Relationship, Drug; Ethylene Glycols; Excitatory Amino Acid Agonists; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Oocytes; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Xenopus | 1999 |
Mapping glutamatergic drive in the vertebrate retina with a channel-permeant organic cation.
Topics: Agmatine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Artifacts; Biological Transport; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Immunohistochemistry; In Vitro Techniques; Kainic Acid; Male; Models, Biological; Models, Molecular; N-Methylaspartate; Neurons; Rabbits; Retina; Retinal Ganglion Cells | 1999 |
Nonproteolytic neuroprotection by human recombinant tissue plasminogen activator.
Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cytoprotection; Fibrinolysin; Hippocampus; Humans; Kainic Acid; Male; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Seizures; Tissue Plasminogen Activator; Zinc | 1999 |
N-methyl-D-aspartate signaling to nuclear activator protein-1 through mechanisms different from those for kainate signaling in murine brain.
Topics: Animals; Brain; Cell Nucleus; Cerebellum; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Dizocilpine Maleate; DNA-Binding Proteins; Hippocampus; Kainic Acid; Kinetics; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Oligonucleotide Probes; Signal Transduction; Transcription Factor AP-1 | 1999 |
Beta-alanine release from the adult and developing hippocampus is enhanced by ionotropic glutamate receptor agonists and cell-damaging conditions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; beta-Alanine; Cell Hypoxia; Drug Synergism; Excitatory Amino Acid Agonists; Female; Free Radicals; Glucose; Hippocampus; Kainic Acid; Male; Mice; N-Methylaspartate; Nitrogen; Oxidative Stress; Sodium | 1999 |
A 'long-term-potentiation-like' facilitation of hippocampal synaptic transmission induced by the nootropic nefiracetam.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Bungarotoxins; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; Indoles; Isoquinolines; Kainic Acid; Long-Term Potentiation; Maleimides; Mecamylamine; N-Methylaspartate; Nicotinic Antagonists; Nootropic Agents; Organ Culture Techniques; Patch-Clamp Techniques; Pyrrolidinones; Rats; Receptors, Nicotinic; Sulfonamides; Synaptic Transmission | 1999 |
Cardiovascular response to group I metabotropic glutamate receptor activation in NTS.
Topics: Animals; Baroreflex; Benzoates; Blood Pressure; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Kynurenic Acid; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sympathetic Nervous System | 1999 |
Induction of cyclooxygenase-2 in brain during acute and chronic ethanol treatment and ethanol withdrawal.
Topics: Alcoholic Intoxication; Animals; Behavior, Animal; Brain; Cyclooxygenase 2; Disease Models, Animal; Enzyme Induction; Ethanol; Immunohistochemistry; Isoenzymes; Kainic Acid; Male; N-Methylaspartate; Peroxidases; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1999 |
Activation of NMDA receptors protects against glutamate neurotoxicity in the retina: evidence for the involvement of neurotrophins.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Growth Factors; Neuroprotective Agents; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptors, N-Methyl-D-Aspartate; Receptors, Nerve Growth Factor; Retina | 1999 |
AV3V lesions attenuate the cardiovascular responses produced by blood-borne excitatory amino acid analogs.
Topics: Animals; Antihypertensive Agents; Arginine Vasopressin; Blood Pressure; Body Weight; Bradycardia; Cerebral Ventricles; Chlorisondamine; Consciousness; Excitatory Amino Acid Agonists; Hormone Antagonists; Kainic Acid; Locomotion; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Renal Circulation; Tachycardia; Vasoconstrictor Agents | 1999 |
Effects of corticosterone on excitatory amino acid responses in dopamine-sensitive neurons in the ventral tegmental area.
Topics: Action Potentials; Aldosterone; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Corticosterone; Dopamine; Drug Synergism; Electrophysiology; Excitatory Amino Acids; In Vitro Techniques; Kainic Acid; Male; Mifepristone; N-Methylaspartate; Neurons; Rats; Receptors, Glucocorticoid; Tegmentum Mesencephali; Time Factors | 1999 |
Potentiation of excitotoxic injury by high concentrations of extracellular reduced glutathione.
Topics: Animals; Antioxidants; Catalase; Cell Death; Cerebral Cortex; Drug Synergism; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Extracellular Space; Glutathione; Glutathione Disulfide; Kainic Acid; Kinetics; Mice; N-Methylaspartate; Neuroglia; Neurons; Pregnatrienes; Time Factors | 1999 |
Effects of puerarin against glutamate excitotoxicity on cultured mouse cerebral cortical neurons.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Isoflavones; Kainic Acid; Kynurenic Acid; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Quinoxalines; Sodium Glutamate | 1998 |
Susceptibility of retinal ganglion cells to excitotoxicity depends on soma size and retinal eccentricity.
Topics: Animals; Cell Size; Cell Survival; Kainic Acid; Male; N-Methylaspartate; Neurotoxins; Rats; Rats, Inbred Strains; Retina; Retinal Ganglion Cells | 1999 |
Predominant expression of nuclear activator protein-1 complex with DNA binding activity following systemic administration of N-methyl-D-aspartate in dentate granule cells of murine hippocampus.
Topics: Animals; Cell Nucleus; Cyclic AMP Response Element-Binding Protein; Cytoplasmic Granules; Dentate Gyrus; Dizocilpine Maleate; DNA; DNA Probes; Electrophoresis, Polyacrylamide Gel; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Immunoblotting; Kainic Acid; Kinetics; Male; Mice; N-Methylaspartate; Neurons; Proto-Oncogene Proteins c-fos; Transcription Factor AP-1 | 1999 |
Cannabinoid CB1 receptor-mediated inhibition of NMDA- and kainate-stimulated noradrenaline and dopamine release in the brain.
Topics: Animals; Benzoxazines; Binding, Competitive; Brain Chemistry; Cannabinoids; Cerebral Cortex; Cyclohexanols; Dopamine; Excitatory Amino Acid Agonists; Guinea Pigs; Kainic Acid; Male; Membranes; Morpholines; N-Methylaspartate; Naphthalenes; Norepinephrine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Stimulation, Chemical | 1999 |
Involvement of NMDA and non-NMDA receptors in transmission of spinal visceral nociception in cat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cats; Excitatory Amino Acid Agonists; Female; Kainic Acid; Male; N-Methylaspartate; Nociceptors; Pain; Quinoxalines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Splanchnic Nerves; Viscera | 1999 |
Neuroprotection by metabotropic glutamate receptor glutamate receptor agonists: LY354740, LY379268 and LY389795.
Topics: Amino Acids; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebral Cortex; DNA Fragmentation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gerbillinae; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neuroprotective Agents; Rats; Staurosporine | 1999 |
Inhibition of excitatory neurotransmitter-nitric oxide signaling pathway by inhalational anesthetics.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Inhalation; Animals; Arginine; Cells, Cultured; Cerebral Cortex; Cyclic GMP; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Guanylate Cyclase; Halothane; Isoflurane; Kainic Acid; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Signal Transduction | 1999 |
Functional activation of punch-cultured magnocellular neuroendocrine cells by glutamate receptor subtypes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arginine Vasopressin; Calcium; Cell Culture Techniques; Cells, Cultured; Cycloleucine; Excitatory Amino Acid Agonists; Fetus; Kainic Acid; N-Methylaspartate; Neurons; Neurophysins; Neurosecretory Systems; Patch-Clamp Techniques; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Supraoptic Nucleus | 1999 |
NMDA and non-NMDA receptor-mediated excitotoxicity are potentiated in cultured striatal neurons by prior chronic depolarization.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cells, Cultured; Corpus Striatum; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Fetus; GluK2 Kainate Receptor; GluK3 Kainate Receptor; Kainic Acid; Membrane Potentials; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Potassium Chloride; Pregnancy; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Measurement of intracellular free zinc concentrations accompanying zinc-induced neuronal death.
Topics: Animals; Cell Death; Cells, Cultured; Excitatory Amino Acid Agonists; Extracellular Space; Fetus; Fluorescent Dyes; Intracellular Fluid; Kainic Acid; Mice; Microscopy, Confocal; N-Methylaspartate; Neocortex; Neuroglia; Neurons; Potassium; Zinc | 1999 |
Role of glutamate receptors and voltage-dependent calcium channels in glutamate toxicity in energy-compromised cortical neurons.
Topics: Agatoxins; Animals; Calcium Channel Blockers; Calcium Channels; Cell Culture Techniques; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Drug Interactions; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glucose; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neuroprotective Agents; Nifedipine; omega-Conotoxin GVIA; Rats; Rats, Wistar; Receptors, Glutamate; Spider Venoms | 1999 |
Glutathione efflux induced by NMDA and kainate: implications in neurotoxicity?
Topics: Animals; Calcium; Dantrolene; Enzyme Inhibitors; Ethanolamines; Female; gamma-Glutamyltransferase; Glutathione; Glutathione Disulfide; Hippocampus; In Vitro Techniques; Isoxazoles; Kainic Acid; Male; N-Methylaspartate; Neurotoxins; Rats; Rats, Sprague-Dawley; Taurine | 1999 |
Ischaemic pre-conditioning in organotypic hippocampal slice cultures is inversely correlated to the induction of the 72 kDa heat shock protein (HSP72).
Topics: Animals; Brain Ischemia; Excitatory Amino Acid Agonists; Glutamic Acid; Heat-Shock Proteins; Hippocampus; HSP72 Heat-Shock Proteins; Ischemic Preconditioning; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1999 |
Regulation of NMDA-stimulated [14C]GABA and [3H]acetylcholine release by striatal glutamate and dopamine receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoates; Carbon Radioisotopes; Corpus Striatum; Cycloleucine; Dopamine Agonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; Male; N-Methylaspartate; Proline; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tritium | 1999 |
Antisense knockdown of glutamate transporters alters the subfield selectivity of kainate-induced cell death in rat hippocampal slice cultures.
Topics: Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Carrier Proteins; Cell Death; Culture Techniques; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Hippocampus; Immunoblotting; Kainic Acid; N-Methylaspartate; Neuroglia; Neurons; Oligonucleotides, Antisense; Propidium; Rats; Receptors, Neurotransmitter; Symporters | 1999 |
Regulation of substantia nigra pars reticulata neuronal activity by excitatory amino acids.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Substantia Nigra | 1999 |
Premotor input to hypoglossal motoneurons from Kölliker-Fuse neurons in decerebrate cats.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cats; Decerebrate State; Electric Stimulation; Electrophysiology; Excitatory Amino Acids; Histocytochemistry; Hypoglossal Nerve; Kainic Acid; Laryngeal Nerves; Microinjections; Motor Neurons; N-Methylaspartate; Phrenic Nerve; Receptors, Glutamate | 1999 |
NMDA- but not kainate-mediated events reduce efficacy of some antiepileptic drugs against generalized tonic-clonic seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Epilepsy, Tonic-Clonic; Kainic Acid; Male; Mice; N-Methylaspartate; Phenobarbital; Phenytoin; Receptors, N-Methyl-D-Aspartate; Valproic Acid | 1999 |
Carnosine protects against excitotoxic cell death independently of effects on reactive oxygen species.
Topics: Animals; Apoptosis; Carnosine; Cells, Cultured; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Wistar; Reactive Oxygen Species | 1999 |
Characterization of AMPA receptors on isolated amacrine-like cells in carp retina.
Topics: Alternative Splicing; Animals; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Cell Separation; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Goldfish; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Phenoxyacetates; Receptors, AMPA; Retina | 1999 |
The ontogeny of glutamate receptors and D-aspartate binding sites in the ovine CNS.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Aspartic Acid; Autoradiography; Binding Sites; Brain; Embryonic and Fetal Development; Fetus; Glutamic Acid; Kainic Acid; N-Methylaspartate; Receptors, Glutamate; Sheep | 1999 |
Locomotor activity and accumbens Fos expression driven by ventral hippocampal stimulation require D1 and D2 receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Benzazepines; Brain Chemistry; Cycloleucine; Dextroamphetamine; Dopamine Agents; Dopamine Antagonists; Excitatory Amino Acid Agonists; Genes, Immediate-Early; Glutamic Acid; Haloperidol; Hippocampus; Kainic Acid; Lidocaine; Locomotion; Male; N-Methylaspartate; Neural Pathways; Neuroprotective Agents; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1999 |
Nuclear factor kappa B-mediated kainate neurotoxicity in the rat and hamster hippocampus.
Topics: Animals; Cell Death; Cell Nucleus; Cricetinae; Dizocilpine Maleate; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hippocampus; Kainic Acid; Mesocricetus; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; NF-kappa B; Rats; Rats, Sprague-Dawley | 1999 |
[The ameliorating effects of a novel NC-1900 on impairments of learning/memory caused by glutamic acid].
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arginine Vasopressin; Avoidance Learning; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Kainic Acid; Learning Disabilities; Male; Memory Disorders; Mice; Mice, Inbred Strains; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oligopeptides; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Resorcinols | 1999 |
Intermediate zone cells express calcium-permeable AMPA receptors and establish close contact with growing axons.
Topics: Action Potentials; Animals; Axons; Benzodiazepines; Biological Transport; Calbindins; Calcium; Cerebral Cortex; Cobalt; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Gestational Age; In Vitro Techniques; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; N-Methylaspartate; Neurites; Neurons; Prosencephalon; Quinoxalines; Receptors, AMPA; S100 Calcium Binding Protein G; Tetrodotoxin | 2000 |
Glutamate and GABA activate different receptors and Cl(-) conductances in crab peptide-secretory neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Brachyura; Cells, Cultured; Chloride Channels; Chlorides; Concanavalin A; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Quisqualic Acid; Receptors, AMPA; Receptors, GABA; Receptors, Glutamate | 2000 |
Prenatal morphine exposure alters N-methyl-D-aspartate- and kainate-induced seizures in adult male rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Fetus; Kainic Acid; Male; Morphine; N-Methylaspartate; Narcotics; Pregnancy; Rats; Seizures | 2000 |
Participation of NMDA and kainate receptors of paraventricular nucleus in cardiovascular responses to glutamate receptor agonist.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Hemodynamics; Kainic Acid; Male; Microinjections; N-Methylaspartate; Paraventricular Hypothalamic Nucleus; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 2000 |
Intracellular survival pathways against glutamate receptor agonist excitotoxicity in cultured neurons. Intracellular calcium responses.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium; Cells, Cultured; Cerebellum; Excitatory Amino Acid Agonists; Exocytosis; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Potassium; Rats; Receptors, Glutamate | 1999 |
Expression of ciliary neurotrophic factor activated by retinal Müller cells in eyes with NMDA- and kainic acid-induced neuronal death.
Topics: Animals; Blotting, Western; Calbindin 2; Calbindins; Cell Count; Cell Death; Ciliary Neurotrophic Factor; Fluorescent Antibody Technique, Indirect; Glial Fibrillary Acidic Protein; Kainic Acid; Male; Microscopy, Confocal; N-Methylaspartate; Neuroglia; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells; S100 Calcium Binding Protein G; Up-Regulation | 2000 |
Behavioral disturbances without amyloid deposits in mice overexpressing human amyloid precursor protein with Flemish (A692G) or Dutch (E693Q) mutation.
Topics: Aggression; Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Animals; Brain; Cell Nucleus; Cerebral Amyloid Angiopathy; Humans; Kainic Acid; Lethal Dose 50; Mice; Mice, Inbred Strains; Mice, Transgenic; N-Methylaspartate; Point Mutation | 2000 |
Attenuation of neuronal death by NMDA and oxygen-glucose deprivation in cortical neurons maintained in high glucose.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Fetus; Glucose; Kainic Acid; Mice; Mice, Inbred ICR; N-Methylaspartate; Neuroglia; Neurons; Neurotoxins | 1999 |
Kainate receptors activate NF-kappaB via MAP kinase in striatal neurones.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcimycin; Calcium; Cells, Cultured; Corpus Striatum; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Flavonoids; Imidazoles; Immunohistochemistry; In Vitro Techniques; Ionophores; Kainic Acid; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neurons; NF-kappa B; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Transcription Factor RelA | 2000 |
Effects of dalargin on excitation induced by L-glutamate agonists in the frog vestibular organs.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Dendrites; Electrophysiology; Enkephalin, Leucine-2-Alanine; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons, Afferent; Rana temporaria; Receptors, Opioid; Synapses; Vestibule, Labyrinth | 2000 |
Long-lasting depolarizations in mitral cells of the rat olfactory bulb.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuculline; Dendrites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Olfactory Bulb; Olfactory Receptor Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 2000 |
Control of synaptic depression by glutamate transporters.
Topics: Action Potentials; Alanine Transaminase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Anti-Bacterial Agents; Antihypertensive Agents; Aspartic Acid; ATP-Binding Cassette Transporters; Benzothiadiazines; Chick Embryo; Cochlear Nucleus; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neural Inhibition; Neuronal Plasticity; Receptors, AMPA; Synaptic Transmission | 2000 |
Differing effects of copper,zinc superoxide dismutase overexpression on neurotoxicity elicited by nitric oxide, reactive oxygen species, and excitotoxins.
Topics: Animals; Astrocytes; Cell Death; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Gene Expression Regulation, Enzymologic; Glutamic Acid; Humans; Hydrazines; Kainic Acid; Mice; Mice, Transgenic; N-Methylaspartate; Neurons; Neurotoxins; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Penicillamine; Reactive Oxygen Species; Spermine; Superoxide Dismutase; Tyrosine; Vitamin K | 2000 |
Neuroprotection by metabotropic glutamate receptor agonists on kainate-induced degeneration of motor neurons in spinal cord slices from adult rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Cell Survival; Choline O-Acetyltransferase; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; In Situ Nick-End Labeling; In Vitro Techniques; Kainic Acid; Male; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord | 2000 |
Differential vulnerabilities of substantia nigra catecholamine neurons to excitatory amino acid-induced degeneration in rat midbrain slices.
Topics: Animals; Catecholamines; Cell Death; Dendrites; Excitatory Amino Acid Agonists; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase | 2000 |
Neuroprotective effects of creatine administration against NMDA and malonate toxicity.
Topics: Administration, Oral; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Corpus Striatum; Creatine; Energy Metabolism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Malonates; Mitochondria; N-Methylaspartate; Neuroprotective Agents; Niacinamide; Rats; Rats, Sprague-Dawley | 2000 |
Synthesis and anticonvulsant and neurotoxic properties of substituted N-phenyl derivatives of the phthalimide pharmacophore.
Topics: Administration, Oral; Animals; Anticonvulsants; Batrachotoxins; Cerebral Cortex; Convulsants; Electroshock; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Kainic Acid; Magnesium Deficiency; Mice; N-Methylaspartate; Patch-Clamp Techniques; Pentylenetetrazole; Phenytoin; Phthalimides; Rats; Seizures; Sodium Channel Blockers; Structure-Activity Relationship; Synaptosomes; Tumor Cells, Cultured | 2000 |
Cellular actions of topiramate: blockade of kainate-evoked inward currents in cultured hippocampal neurons.
Topics: Animals; Anticonvulsants; Cells, Cultured; Dose-Response Relationship, Drug; Evoked Potentials; Excitatory Amino Acids; Fructose; Hippocampus; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Topiramate | 2000 |
Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture.
Topics: Animals; Blotting, Western; Cell Death; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Excitatory Amino Acid Agonists; Flurbiprofen; Immunohistochemistry; Isoenzymes; Kainic Acid; Membrane Proteins; Mice; N-Methylaspartate; Neurons; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2000 |
Behavioural effects of glutamate receptor agonists in morphine-dependent rats.
Topics: Animals; Behavior, Animal; Brain Chemistry; Discrimination, Psychological; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Isosorbide Dinitrate; Kainic Acid; Male; Morphine Dependence; N-Methylaspartate; Naloxone; Narcotic Antagonists; Nitric Oxide Donors; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Involvement of NMDA-receptor in kainate-induced neurotoxicity in cultured fetal retinal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Death; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Retina | 2000 |
Intracellular glutathione levels determine cerebellar granule neuron sensitivity to excitotoxic injury by kainic acid.
Topics: Animals; Cell Survival; Cerebellum; Excitatory Amino Acid Agonists; Fluoresceins; Glutamic Acid; Glutathione; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Radiation-Protective Agents; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2000 |
Differential modulatory roles of cholera toxin and pertussis toxin in the regulation of pain responses induced by excitatory amino acids administered intrathecally in mice.
Topics: Adjuvants, Immunologic; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cholera Toxin; Excitatory Amino Acid Agonists; Injections, Spinal; Kainic Acid; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Pain; Pertussis Toxin; Spinal Cord; Virulence Factors, Bordetella | 2000 |
Neuronal cell death and reactive oxygen species.
Topics: Animals; Animals, Newborn; Calcium; Cell Death; Cell Survival; Cells, Cultured; Flow Cytometry; Fluorescent Dyes; Intracellular Fluid; Ischemia; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Reactive Oxygen Species | 2000 |
Effects of mild versus deep hypothermia on a cloned human brain glutamate transporter (GLT-1) expressed in Chinese hamster ovary cells.
Topics: Adult; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Biological Transport; Cell Division; Cell Membrane; Cerebral Cortex; CHO Cells; Cloning, Molecular; Cricetinae; Gene Library; Glutamic Acid; Humans; Hypothermia; Kainic Acid; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Quisqualic Acid; Recombinant Proteins; Temperature | 2000 |
Motor stimulation following bilateral injection of the group-I metabotropic glutamate receptor agonist into the dorsal striatum of rats: evidence against dependence on ionotropic glutamate receptors.
Topics: Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Male; Microinjections; Motor Activity; N-Methylaspartate; Neostriatum; Neurons; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Stimulation, Chemical | 2000 |
Glufosinate ammonium stimulates nitric oxide production through N-methyl D-aspartate receptors in rat cerebellum.
Topics: Aminobutyrates; Animals; Cerebellum; Glutamic Acid; Herbicides; Kainic Acid; Male; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate | 2000 |
Functional ionotropic glutamate receptors emerge during terminal cell division and early neuronal differentiation of rat neuroepithelial cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bromodeoxyuridine; Calcium; Cell Differentiation; Cells, Cultured; DNA Primers; Epithelial Cells; Epitopes; Excitatory Amino Acid Agonists; Female; Flow Cytometry; Gene Expression Regulation, Developmental; Kainic Acid; Membrane Potentials; Mitosis; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Polymerase Chain Reaction; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Stem Cells; Telencephalon; Transcription, Genetic | 2000 |
Synaptic activation of presynaptic kainate receptors on hippocampal mossy fiber synapses.
Topics: Animals; Cells, Cultured; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Mossy Fibers, Hippocampal; N-Methylaspartate; Patch-Clamp Techniques; Potassium; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Synapses; Synaptic Transmission | 2000 |
Interrelationships of GABAergic, serotoninergic and excitatory amino acid systems in its regulatory effect on prolactin secretion in prepubertal rats.
Topics: 5-Hydroxytryptophan; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Excitatory Amino Acids; Female; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Kainic Acid; N-Methylaspartate; p-Chloroamphetamine; Prolactin; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Serotonin; Sexual Maturation | 2000 |
In situ Ca2+ imaging reveals neurotransmitter receptors for glutamate in taste receptor cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cells, Cultured; Dextrans; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Fluorescent Dyes; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Microscopy, Confocal; N-Methylaspartate; Neurotransmitter Agents; Organic Chemicals; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Taste Buds | 2000 |
Ionotropic glutamate receptors expressed in human retinoblastoma Y79 cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Blotting, Northern; Calcium; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Fura-2; Gene Expression; Humans; Intracellular Fluid; Kainic Acid; N-Methylaspartate; Photoreceptor Cells, Vertebrate; Receptors, Glutamate; Retinoblastoma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured | 2000 |
A quantitative analysis of L-glutamate-regulated Na+ dynamics in mouse cortical astrocytes: implications for cellular bioenergetics.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Astrocytes; Benzothiadiazines; Biological Transport; Carrier Proteins; Cells, Cultured; Cerebral Cortex; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Kainic Acid; Kinetics; Mice; Models, Theoretical; N-Methylaspartate; Sodium; Symporters | 2000 |
Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically.
Topics: Alzheimer Disease; Animals; Brain; Cells, Cultured; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression; Humans; Infarction, Middle Cerebral Artery; Kainic Acid; Membrane Proteins; Mice; Mice, Knockout; Mice, Transgenic; N-Methylaspartate; Nerve Degeneration; Neurons; Presenilin-1 | 2000 |
Dendritic and axonal targeting of type 5 metabotropic glutamate receptor is regulated by homer1 proteins and neuronal excitation.
Topics: Animals; Axons; Carrier Proteins; Cells, Cultured; Cerebellum; Corpus Striatum; Dendrites; Excitatory Amino Acid Agonists; Homer Scaffolding Proteins; Humans; Kainic Acid; Mice; N-Methylaspartate; Neurites; Neuronal Plasticity; Neurons; Neuropeptides; Potassium Channel Blockers; Protein Binding; Protein Isoforms; Protein Transport; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Recombinant Proteins; Synaptophysin; Transfection | 2000 |
Roles of glutamate receptor subtypes in the development of vestibular compensation after unilateral labyrinthectomy in the guinea pig.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Azepines; Denervation; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ear, Inner; Functional Laterality; Guinea Pigs; Kainic Acid; Male; Muscle Relaxants, Central; N-Methylaspartate; Neuronal Plasticity; Nystagmus, Pathologic; Oxazolidinones; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Recovery of Function; Time Factors; Vestibular Nerve; Vestibular Nuclei | 2000 |
Effects of N-methyl-D-aspartate, kainate or veratridine on extracellular concentrations of free D-serine and L-glutamate in rat striatum: an in vivo microdialysis study.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Kainic Acid; Male; Microdialysis; N-Methylaspartate; Perfusion; Rats; Rats, Wistar; Serine; Time Factors; Veratridine | 2000 |
Chemical stimulation of the dorsomedial hypothalamus elevates plasma ACTH in conscious rats.
Topics: Adrenocorticotropic Hormone; Air Movements; Animals; Bicuculline; Blood Pressure; Consciousness; Dorsomedial Hypothalamic Nucleus; Excitatory Amino Acid Agonists; GABA Antagonists; Heart Rate; Hypothalamo-Hypophyseal System; Kainic Acid; Locomotion; Male; Microinjections; N-Methylaspartate; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Stress, Physiological | 2001 |
The effects of glutamate receptor agonists on neurotensin release using in vivo microdialysis.
Topics: Animals; Corpus Striatum; Excitatory Amino Acid Agonists; Kainic Acid; Male; Microdialysis; N-Methylaspartate; Neurotensin; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Tetrodotoxin | 2001 |
Mechanisms of [2,3-butanedione bis(N4-dimethylthiosemicarbazone)]zinc (Zn-ATSM2)-induced protection of cultured hippocampal neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity.
Topics: Animals; Calcium; Cells, Cultured; Embryo, Mammalian; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Organometallic Compounds; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Thiosemicarbazones | 2000 |
Calcitonin potentiates oxygen-glucose deprivation-induced neuronal death.
Topics: Animals; Apoptosis; Calcitonin; Cell Death; Cells, Cultured; Culture Media, Serum-Free; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glucose; Hypoxia-Ischemia, Brain; Kainic Acid; Mice; N-Methylaspartate; Necrosis; Neurons; Oxygen; Receptors, AMPA; Salmon; Staurosporine | 2001 |
Estrogen differentially alters NMDA- and kainate-induced seizures in prenatally morphine- and saline-exposed adult female rats.
Topics: Analgesics, Opioid; Animals; Estradiol; Excitatory Amino Acid Agonists; Female; Kainic Acid; Morphine; N-Methylaspartate; Ovariectomy; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Seizures; Sodium Chloride; Stereotyped Behavior | 2000 |
Cortical and striatal neuronal cultures of the same embryonic origin show intrinsic differences in glutamate receptor expression and vulnerability to excitotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Cerebral Cortex; Corpus Striatum; Gene Expression Regulation; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neurotoxins; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Transcription, Genetic | 2001 |
Role of non-NMDA receptors in vasopressin and oxytocin release from rat hypothalamo-neurohypophysial explants.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Glutamates; Hypothalamo-Hypophyseal System; Kainic Acid; Kinetics; Male; N-Methylaspartate; Organ Culture Techniques; Oxytocin; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Vasopressins | 2001 |
N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influx.
Topics: 2,4-Dinitrophenol; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Cyclosporine; Dibucaine; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluoresceins; Fluorescent Dyes; Glutamic Acid; Heterocyclic Compounds, 3-Ring; Imidazoles; Kainic Acid; Mitochondria; Motor Neuron Disease; Motor Neurons; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Neurotoxins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Rhodamines; Spinal Cord; Superoxide Dismutase; Uncoupling Agents | 2001 |
Tissue plasminogen activator protects hippocampal neurons from oxygen-glucose deprivation injury.
Topics: Animals; Antibodies; Apoptosis; Cell Hypoxia; Cells, Cultured; Culture Media, Conditioned; Excitatory Amino Acid Agonists; Fibrinolysin; Glucose; Glutamic Acid; Hippocampus; Humans; Hydrogen Peroxide; Kainic Acid; Microglia; Microscopy, Fluorescence; N-Methylaspartate; Neuroprotective Agents; Nitric Oxide Donors; Oxidants; Oxygen; Penicillamine; Plasminogen Activator Inhibitor 1; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tissue Plasminogen Activator | 2001 |
Blockade of AMPA/kainate receptors can either decrease or increase the survival of cultured neocortical cells depending on the stage of maturation.
Topics: Animals; Benzodiazepines; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Kainic Acid; N-Methylaspartate; Neocortex; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid | 2001 |
Effect of excitatory amino acids on serum TSH and thyroid hormone levels in freely moving rats.
Topics: Animals; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Thyrotropin; Thyroxine; Triiodothyronine | 2000 |
Effects of glutathione depletion by 2-cyclohexen-1-one on excitatory amino acids-induced enhancement of activator protein-1 DNA binding in murine hippocampus.
Topics: Animals; Binding Sites; Cyclohexanones; Excitatory Amino Acids; Glutathione; Hippocampus; Kainic Acid; Kinetics; Male; Mice; Mice, Inbred Strains; Motor Activity; N-Methylaspartate; Oligodeoxyribonucleotides; Posture; Seizures; Time Factors; Transcription Factor AP-1; Tremor | 2001 |
Expression and regulation of Na pump isoforms in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport; Cerebellum; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Isoenzymes; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Potassium Radioisotopes; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase | 2001 |
Presynaptic N-methyl-D-aspartate receptor activation inhibits neurotransmitter release through nitric oxide formation in rat hippocampal nerve terminals.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbon Radioisotopes; Excitatory Amino Acid Agonists; Exocytosis; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Nitric Oxide; Presynaptic Terminals; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Synaptosomes; Tritium | 2001 |
Activation of p44/p42 MAP kinase in striatal neurons via kainate receptors and PI3 kinase.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Androstadienes; Animals; Corpus Striatum; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Kainic Acid; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neurons; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Wortmannin | 2001 |
The noradrenaline-dopamine interaction in the rat medial prefrontal cortex studied by multi-probe microdialysis.
Topics: Adrenergic beta-Antagonists; Animals; Carbachol; Clonidine; Dialysis Solutions; Dopamine; Dopamine Uptake Inhibitors; Functional Laterality; Kainic Acid; Locus Coeruleus; Male; Microdialysis; N-Methylaspartate; Nomifensine; Norepinephrine; Nucleus Accumbens; Prazosin; Prefrontal Cortex; Propranolol; Rats; Rats, Wistar; Time Factors | 2001 |
Neuroprotective effects of lamotrigine and remacemide on excitotoxicity induced by glutamate agonists in isolated chick retina.
Topics: Acetamides; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chick Embryo; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kainic Acid; L-Lactate Dehydrogenase; Lamotrigine; N-Methylaspartate; Necrosis; Neuroprotective Agents; Phenethylamines; Retina; Retinal Ganglion Cells; Triazines | 2001 |
Intrinsic optical signals in respiratory brain stem regions of mice: neurotransmitters, neuromodulators, and metabolic stress.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine; Adenosine Triphosphate; Animals; Animals, Newborn; Anti-Bacterial Agents; Antihypertensive Agents; Diazoxide; Energy Metabolism; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glyburide; Hypoglossal Nerve; Hypoglycemic Agents; Hypoxia; Kainic Acid; Macrolides; Mice; Mitochondrial Swelling; N-Methylaspartate; Optics and Photonics; Organ Culture Techniques; Ouabain; Potassium Channels; Respiratory Center; Sodium-Potassium-Exchanging ATPase; Tetrodotoxin | 2001 |
Characterization of ionotropic glutamate receptors in human lymphocytes.
Topics: 2-Amino-5-phosphonovalerate; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antibodies, Monoclonal; Calcium; CD3 Complex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Kainic Acid; Lymphocytes; N-Methylaspartate; Phytohemagglutinins; Quinoxalines; Receptors, Glutamate | 2001 |
Delayed postnatal development of NMDA receptor function in medium-sized neurons of the rat striatum.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Corpus Striatum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Organ Culture Techniques; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2001 |
Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Animals; Cells, Cultured; Dithiothreitol; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Hydrogen-Ion Concentration; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neuroprotective Agents; Nootropic Agents; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sesquiterpenes; Spermine; Zinc | 2001 |
Dependence of excitotoxic neurodegeneration on mitochondrial aconitase inactivation.
Topics: Aconitate Hydratase; Animals; Astrocytes; Cell Death; Cell Fractionation; Cells, Cultured; Enzyme Inhibitors; Fumarate Hydratase; Glucose; Kainic Acid; Metalloporphyrins; Mitochondria; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Oxygen; Paraquat; Rats; Superoxides | 2001 |
Decrease in level of APG-2, a member of the heat shock protein 110 family, in murine brain following systemic administration of kainic acid.
Topics: Animals; Behavior, Animal; Brain; Brain Chemistry; Excitatory Amino Acid Agonists; Heat-Shock Proteins; HSP110 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Immunoblotting; Kainic Acid; Male; Mice; N-Methylaspartate | 2001 |
NMDA receptors mediate hypoxic spine loss in cultured neurons.
Topics: Animals; Anti-Bacterial Agents; Astrocytes; Calcium Channel Blockers; Carbocyanines; Cell Hypoxia; Cell Surface Extensions; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glucose; Hypoxia, Brain; Ionophores; Kainic Acid; Mice; N-Methylaspartate; Neurons; Oxygen; Peptides; Potassium Chloride; Tetrodotoxin; Veratridine | 2001 |
Suppression of presynaptic responses to adenosine by activation of NMDA receptors.
Topics: Action Potentials; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Baclofen; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; GABA Agonists; Glycine; Hippocampus; In Vitro Techniques; Kainic Acid; Long-Term Potentiation; Male; N-Methylaspartate; Phenethylamines; Presynaptic Terminals; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Time Factors; Triazines; Triazoles | 2001 |
Stimulatory effects of centrally injected kainate and N-methyl-D-aspartate on gastric acid secretion in anesthetized rats.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Atropine; Brain; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gastric Acid; Gastric Mucosa; Kainic Acid; Male; Muscarinic Antagonists; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Vagotomy; Vagus Nerve | 2001 |
Apoptosis and necrosis occurring in excitotoxic cell death in isolated chick embryo retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspases; Chick Embryo; Excitatory Amino Acid Agonists; In Situ Nick-End Labeling; Kainic Acid; Kinetics; L-Lactate Dehydrogenase; N-Methylaspartate; Necrosis; Receptors, Glutamate; Retina | 2001 |
Comparison of excitotoxic profiles of ATPA, AMPA, KA and NMDA in organotypic hippocampal slice cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Isoxazoles; Kainic Acid; Microtubule-Associated Proteins; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Nissl Bodies; Nuclear Proteins; Propidium; Propionates; Quinoxalines; Rats; Rats, Wistar | 2001 |
Nitric oxide produced by non-motoneuron cells enhances rat embryonic motoneuron sensitivity to excitotoxins: comparison in mixed neuron/glia or purified cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Cell Communication; Cell Differentiation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Kainic Acid; Magnesium; N-Methylaspartate; Neuroglia; Neurotoxins; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2001 |
GABA release induced by aspartate-mediated activation of NMDA receptors is modulated by dopamine in a selective subpopulation of amacrine cells.
Topics: Amacrine Cells; Animals; Aspartic Acid; Carrier Proteins; Cell Survival; Chickens; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Immunohistochemistry; Isoenzymes; Kainic Acid; L-Lactate Dehydrogenase; Membrane Proteins; Membrane Transport Proteins; N-Methylaspartate; Organic Anion Transporters; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2001 |
Influence of serotonin on the glutamate-induced excitations of secondary vestibular neurons in the rat.
Topics: Animals; Evoked Potentials; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin Receptor Agonists; Vestibular Nuclei | 2001 |
Rapid and reversible changes in dendrite morphology and synaptic efficacy following NMDA receptor activation: implication for a cellular defense against excitotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Death; Cell Size; Dendrites; Excitatory Amino Acid Agonists; Fluorescent Dyes; Hippocampus; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium; Synaptic Transmission; Time Factors | 2001 |
Increased susceptibility to ischemic brain injury in cyclooxygenase-1-deficient mice.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Cyclooxygenase 1; Disease Susceptibility; Excitatory Amino Acid Agonists; Female; Infarction, Middle Cerebral Artery; Isoenzymes; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurotoxins; Parietal Lobe; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Stroke | 2001 |
Effects of glutamate receptor agonist on extracellular glutamate dynamics during moderate cerebral ischemia.
Topics: Animals; Carotid Artery, Common; Cerebrovascular Circulation; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Ischemic Attack, Transient; Kainic Acid; Male; Microdialysis; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Glutamate; Stroke | 2001 |
Role of glial glutamate transporters in the facilitatory action of FK960 on hippocampal neurotransmission.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Benzamides; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dentate Gyrus; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Female; Glutamic Acid; Indoles; Isoquinolines; Kainic Acid; Long-Term Potentiation; Maleimides; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nootropic Agents; Oocytes; Patch-Clamp Techniques; Perforant Pathway; Piperazines; Protein Synthesis Inhibitors; Rats; Receptors, Glutamate; Recombinant Fusion Proteins; Signal Transduction; Sulfonamides; Synaptic Transmission; Xenopus laevis | 2001 |
[Ability of novel non-competitive glutamate receptor blocking agents to weaken motor disorders in animals].
Topics: Animals; Anticonvulsants; Ataxia; Benzene Derivatives; Catalepsy; Cations; Cyclohexanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Haloperidol; Kainic Acid; Mice; N-Methylaspartate; Parkinsonian Disorders; Seizures; Structure-Activity Relationship | 2001 |
Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hippocampus; Hypoxia-Ischemia, Brain; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Pyramidal Cells; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2002 |
Effects of metabotropic glutamate receptor agonists and antagonists on D-aspartate release from mouse cerebral cortical and striatal slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred Strains; N-Methylaspartate; Receptors, Metabotropic Glutamate; Tritium | 2001 |
E-p-methoxycinnamic acid protects cultured neuronal cells against neurotoxicity induced by glutamate.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Cinnamates; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2002 |
Localization of activator protein-1 complex with DNA binding activity in mitochondria of murine brain after in vivo treatment with kainate.
Topics: Animals; Base Sequence; Binding Sites; Binding, Competitive; Brain; Brain Chemistry; Cerebral Cortex; DNA, Mitochondrial; Hippocampus; Immunoblotting; Immunohistochemistry; Kainic Acid; Ligands; Macromolecular Substances; Male; Mice; Microscopy, Electron; Mitochondria; N-Methylaspartate; Proto-Oncogene Proteins c-fos; Subcellular Fractions; Transcription Factor AP-1 | 2002 |
Nuclear degradation of particular Fos family members expressed following injections of NMDA and kainate in murine hippocampus.
Topics: Animals; Blotting, Western; Cell Nucleus; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Fos-Related Antigen-2; Hippocampus; Injections; Kainic Acid; Mice; N-Methylaspartate; Proto-Oncogene Proteins c-fos; Transcription Factors | 2002 |
Interactions between GABAergic and aminoacidergic pathways in the control of gonadotropin and GH secretion in pre-pubertal female rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Baclofen; Bicuculline; Excitatory Amino Acids; Female; Follicle Stimulating Hormone; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Human Growth Hormone; Kainic Acid; Luteinizing Hormone; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Sexual Maturation | 2002 |
Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Free Radical Scavengers; Furans; Glutamic Acid; Kainic Acid; Lignans; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Peroxides; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid | 2002 |
Impairment of neuronal nitric oxide synthase-dependent dilation of cerebral arterioles during chronic alcohol consumption.
Topics: Alcohol Drinking; Animals; Arterioles; Ethanol; Kainic Acid; Male; N-Methylaspartate; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pia Mater; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Vasodilation | 2002 |
Implication of p53 and caspase-3 in kainic acid but not in N-methyl-D-aspartic acid-induced apoptosis in organotypic hippocampal mouse cultures.
Topics: Animals; Caspase 3; Caspases; DNA Fragmentation; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Neurons; Neurotoxins; Organ Culture Techniques; Tumor Suppressor Protein p53 | 2002 |
Interaction of excitatory amino acid agonists with cortical afterdischarges in developing rats.
Topics: Aging; Animals; Cerebral Cortex; Electric Stimulation; Electrophysiology; Epilepsy; Excitatory Amino Acid Agonists; Homocysteine; Kainic Acid; N-Methylaspartate; Rats; Rats, Wistar | 2002 |
Receptor-activated calcium signals in tangentially migrating cortical cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Calcium; Calcium Signaling; Cell Movement; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Agonists; GABA-A Receptor Agonists; Kainic Acid; Male; Muscimol; N-Methylaspartate; Neurons; Organ Culture Techniques; Pregnancy; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Glutamate; Tetrodotoxin | 2002 |
Non-ionotropic cross-talk between AMPA and NMDA receptors in rodent hippocampal neurones.
Topics: Animals; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neural Inhibition; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptor Cross-Talk; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2002 |
Glutamate cascade to cAMP response element-binding protein phosphorylation in cultured striatal neurons through calcium-coupled group I metabotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzopyrans; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Drug Interactions; Glutamic Acid; Kainic Acid; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Phosphorylation; Rats; Receptors, Metabotropic Glutamate; Type C Phospholipases | 2002 |
Rat motoneuron cell death in development correlates with loss of N-methyl-D-aspartate receptors.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Death; Electric Conductivity; Excitatory Amino Acid Agonists; Fluorescence; In Vitro Techniques; Iontophoresis; Isoquinolines; Kainic Acid; Male; Motor Neurons; N-Methylaspartate; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2002 |
Nitric oxide synthase inhibition and glutamate binding in quinolinate-lesioned rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cell Membrane; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Kainic Acid; Male; Molsidomine; N-Methylaspartate; Nerve Degeneration; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Quinolinic Acid; Quisqualic Acid; Rats; Rats, Wistar; Tritium | 2002 |
Facilitation of glutamate release by ionotropic glutamate receptors in osteoblasts.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Division; Cells, Cultured; Glutamic Acid; Kainic Acid; N-Methylaspartate; Osteoblasts; Potassium Chloride; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Reverse Transcriptase Polymerase Chain Reaction; Skull | 2002 |
Carbon monoxide and metabotropic glutamate receptors in rat nucleus tractus solitarii: participation in cardiovascular effect.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Carbon Monoxide; Cardiovascular System; Cycloleucine; Deuteroporphyrins; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Heme Oxygenase (Decyclizing); Hemin; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Solitary Nucleus | 2002 |
Exogenous growth factors stimulate the regeneration of ganglion cells in the chicken retina.
Topics: Animals; Bromodeoxyuridine; Cell Division; Chickens; Colchicine; Fibroblast Growth Factor 2; Insulin; Kainic Acid; N-Methylaspartate; Nerve Regeneration; Retinal Ganglion Cells | 2002 |
Regulation of glutamatergic neurotransmission in the striatum by presynaptic adenylyl cyclase-dependent processes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenergic beta-Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bucladesine; Calcium; Calmodulin; Corpus Striatum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Feedback; Female; Glutamic Acid; Imidazoles; Imines; Isoenzymes; Isoproterenol; Isoquinolines; Kainic Acid; Male; Mice; N-Methylaspartate; Nerve Tissue Proteins; Propranolol; Receptors, Adrenergic, beta; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Presynaptic; Second Messenger Systems; Sulfonamides; Synaptic Transmission; Trifluoperazine | 2003 |
Effects of calcium and glutamate receptor agonists on leaf consumption by lepidopteran neonates.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Feeding Behavior; Kainic Acid; Lepidoptera; N-Methylaspartate; Plant Leaves | 2003 |
Chronic NMDA receptor blockade from birth delays the maturation of NMDA currents, but does not affect AMPA/kainate currents.
Topics: Adaptation, Physiological; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Calcium; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Kainic Acid; N-Methylaspartate; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synapses | 2003 |
Rat retinal ganglion cell loss caused by kainate, NMDA and ischemia correlates with a reduction in mRNA and protein of Thy-1 and neurofilament light.
Topics: Animals; Blotting, Western; Excitatory Amino Acid Agonists; Eye; Immunohistochemistry; Ischemia; Kainic Acid; Kinetics; Male; Microinjections; N-Methylaspartate; Neurofilament Proteins; Rats; Rats, Wistar; Reperfusion Injury; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thy-1 Antigens; Vitreous Body | 2003 |
Vampire bat salivary plasminogen activator (desmoteplase): a unique fibrinolytic enzyme that does not promote neurodegeneration.
Topics: Animals; Cell Count; Cell Survival; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Fibrinolytic Agents; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; N-Methylaspartate; Neurodegenerative Diseases; Neurons; Plasminogen Activators; Tissue Plasminogen Activator | 2003 |
In vitro hypoxia and excitotoxicity in human brain induce calcineurin-Bcl-2 interactions.
Topics: Adult; Blotting, Western; Calcineurin; Calcium Channels; Caspase 3; Caspases; Cerebral Cortex; Enzyme Inhibitors; Enzyme Precursors; Female; Humans; Hypoxia, Brain; Immunosuppressive Agents; In Vitro Techniques; Inositol 1,4,5-Trisphosphate Receptors; Kainic Acid; Male; Middle Aged; N-Methylaspartate; Neurotoxins; Okadaic Acid; Precipitin Tests; Proto-Oncogene Proteins c-bcl-2; Receptors, Cytoplasmic and Nuclear; Spectrin; Tacrolimus | 2003 |
Lead can inhibit NMDA-, K(+)-, QA/KA-induced increases in intracellular free Ca2+ in cultured rat hippocampal neurons.
Topics: Animals; Calcium; Cognition Disorders; Disease Models, Animal; Hippocampus; Kainic Acid; Lead; Learning Disabilities; Microscopy, Confocal; N-Methylaspartate; Neurons; Potassium; Quisqualic Acid; Rats; Rats, Wistar | 2002 |
Quercetin attenuates oxygen-glucose deprivation- and excitotoxin-induced neurotoxicity in primary cortical cell cultures.
Topics: Animals; Antioxidants; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glucose; Kainic Acid; Mice; Mice, Inbred ICR; N-Methylaspartate; Neuroglia; Neurons; Oxygen; Quercetin | 2003 |
The GABAA receptor agonist THIP is neuroprotective in organotypic hippocampal slice cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Newborn; Cell Death; Dose-Response Relationship, Drug; Glutamate Decarboxylase; Hippocampus; Isoxazoles; Kainic Acid; Muscimol; N-Methylaspartate; Neuroprotective Agents; Organ Culture Techniques; Propidium; Pyramidal Cells; Rats; Rats, Wistar; Time Factors | 2003 |
In vivo neuroprotective role of NMDA receptors against kainate-induced excitotoxicity in murine hippocampal pyramidal neurons.
Topics: Animals; Behavior, Animal; Cytoprotection; Dizocilpine Maleate; DNA Fragmentation; Excitatory Amino Acid Antagonists; Hippocampus; Injections, Intraperitoneal; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Transcription Factor AP-1; Trimethyltin Compounds | 2003 |
The ability of new non-competitive glutamate receptor blockers to weaken motor disorders in animals.
Topics: Animals; Ataxia; Behavior, Animal; Catalepsy; Diamines; Disease Models, Animal; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Haloperidol; Kainic Acid; Memantine; Mice; Mice, Inbred Strains; N-Methylaspartate; Quaternary Ammonium Compounds; Seizures; Structure-Activity Relationship; Time Factors | 2003 |
Basal ganglia efferents to the brainstem centers controlling postural muscle tone and locomotion: a new concept for understanding motor disorders in basal ganglia dysfunction.
Topics: Animals; Atropine; Basal Ganglia; Basal Ganglia Diseases; Bicuculline; Brain Stem; Cats; Choline O-Acetyltransferase; Disease Models, Animal; Efferent Pathways; Electric Stimulation; Electromyography; Evoked Potentials, Motor; Excitatory Amino Acid Agonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Kainic Acid; Locomotion; Muscarinic Antagonists; Muscimol; Muscle Tonus; N-Methylaspartate; Neural Inhibition; Picrotoxin; Stimulation, Chemical | 2003 |
Bombycis corpus extract (BCE) protects hippocampal neurons against excitatory amino acid-induced neurotoxicity.
Topics: Animals; Bombyx; Cell Count; Cell Survival; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Medicine, East Asian Traditional; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Tissue Extracts | 2003 |
ATP inhibits NMDA receptors after heterologous expression and in cultured hippocampal neurons and attenuates NMDA-mediated neurotoxicity.
Topics: Adenosine; Adenosine Triphosphate; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Nucleotides; Oocytes; Patch-Clamp Techniques; Protein Subunits; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 2003 |
Tunicamycin inhibits NMDA and AMPA receptor responses independently of N-glycosylation.
Topics: Animals; Anti-Bacterial Agents; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Glycosylation; Hippocampus; In Vitro Techniques; Kainic Acid; Long-Term Potentiation; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Time Factors; Tunicamycin | 2003 |
Profound increase in sensitivity to glutamatergic- but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6.
Topics: Animals; Astrocytes; Brain; Cholinergic Agonists; Excitatory Amino Acid Agents; Glial Fibrillary Acidic Protein; Interleukin-6; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Seizures; Tumor Necrosis Factor-alpha | 2003 |
Inhibition of glutamate-induced nitric oxide synthase activation by dopamine in cultured rat retinal neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Dopamine; Dopamine Agonists; Enzyme Activation; Excitatory Amino Acid Agonists; Kainic Acid; N-Methylaspartate; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Retina | 2003 |
Neocortical neurons cultured from mice with expanded CAG repeats in the huntingtin gene: unaltered vulnerability to excitotoxins and other insults.
Topics: Animals; Apoptosis; Cell Culture Techniques; Gene Expression; Genotype; Huntingtin Protein; Huntington Disease; Immunoblotting; Immunohistochemistry; Kainic Acid; Mice; Mice, Transgenic; N-Methylaspartate; Neocortex; Nerve Tissue Proteins; Neurons; Neurotoxins; Nuclear Proteins; Oxidative Stress; Peptides; Trinucleotide Repeat Expansion | 2003 |
Glycogen synthase kinase-3 inhibitors protect central neurons against excitotoxicity.
Topics: Aminophenols; Animals; Cell Survival; Cells, Cultured; Central Nervous System; Cerebellum; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycogen Synthase Kinase 3; Hippocampus; Indoles; Kainic Acid; Maleimides; N-Methylaspartate; Neurons; Neuroprotective Agents; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
Local differences in GABA release induced by excitatory amino acids during retina development: selective activation of NMDA receptors by aspartate in the inner retina.
Topics: Animals; Aspartic Acid; Carrier Proteins; Chick Embryo; Excitatory Amino Acids; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Immunohistochemistry; In Vitro Techniques; Kainic Acid; Membrane Proteins; Membrane Transport Proteins; N-Methylaspartate; Organic Anion Transporters; Receptors, N-Methyl-D-Aspartate; Retina; Zygote | 2003 |
Neurons derived from embryonic stem (ES) cells resemble normal neurons in their vulnerability to excitotoxic death.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Cell Lineage; Cell Survival; Cells, Cultured; Coculture Techniques; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Glutamic Acid; Immunohistochemistry; Kainic Acid; Mice; N-Methylaspartate; Neuroglia; Neurons; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA; Stem Cells | 2003 |
PARP cleavage, DNA fragmentation, and pyknosis during excitotoxin-induced neuronal death.
Topics: Animals; Blotting, Western; Caspase 3; Caspases; Cell Death; Cell Survival; Cerebral Cortex; DNA Fragmentation; Excitatory Amino Acid Agonists; Fluorescent Dyes; In Situ Nick-End Labeling; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Phenotype; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Rats; Rats, Long-Evans; Spectrin | 2003 |
The PARP inhibitor benzamide protects against kainate and NMDA but not AMPA lesioning of the mouse striatum in vivo.
Topics: Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzamides; Brain Injuries; Chromatography, High Pressure Liquid; Corpus Striatum; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; NAD; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Time Factors | 2004 |
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae.
Topics: Alanine; Animals; Biguanides; Calcium Channel Blockers; Cattle; D-Aspartic Acid; Diltiazem; Dizocilpine Maleate; Drug Synergism; Glucose; Glutamic Acid; Glycine; Humans; Kainic Acid; N-Methylaspartate; Nitrendipine; omega-Conotoxins; Perfusion; Piperidines; Polyamines; Receptors, Glutamate; Retina; Tritium; Verapamil | 2003 |
Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons.
Topics: Animals; Benzothiadiazines; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Indoles; Kainic Acid; Memantine; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Purkinje Cells; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2003 |
Release of homocysteic acid from rat thalamus following stimulation of somatosensory afferents in vivo: feasibility of glial participation in synaptic transmission.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Homocysteine; Iontophoresis; Kainic Acid; Male; Methionine; N-Methylaspartate; Neuroglia; Physical Stimulation; Piperazines; Rats; Rats, Wistar; Sulfur Isotopes; Synaptic Transmission; Thalamus; Vibrissae | 2004 |
Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Cellular Senescence; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Eye Proteins; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Picrotoxin; Receptors, AMPA; Receptors, GABA; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Retina; Taurine | 2004 |
AMPA, not NMDA, activates RhoA GTPases and subsequently phosphorylates moesin.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Line; Excitatory Amino Acid Agonists; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Kainic Acid; Microfilament Proteins; N-Methylaspartate; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; rho-Associated Kinases; rhoA GTP-Binding Protein | 2004 |
Guanine nucleotides inhibit NMDA and kainate-induced neurotoxicity in cultured rat hippocampal and neocortical neurons.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Guanine Nucleotides; Hippocampus; Kainic Acid; N-Methylaspartate; Neocortex; Neurons; Rats; Rats, Wistar | 2004 |
Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist.
Topics: Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fructose; In Vitro Techniques; Kainic Acid; Male; Mice; N-Methylaspartate; Receptors, Kainic Acid; Seizures; Topiramate | 2004 |
Extracellular taurine in the substantia nigra: taurine-glutamate interaction.
Topics: Adrenergic Agents; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain Chemistry; Calcium; Chelating Agents; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Excitatory Amino Acid Antagonists; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Ketamine; Male; Membrane Potentials; Microdialysis; N-Methylaspartate; Oxidopamine; Potassium; Rats; Rats, Sprague-Dawley; Substantia Nigra; Taurine; Time Factors; Zinc | 2004 |
Comparison of the anticonvulsive activities of organic mono- and dications with their abilities to inhibit NMDA and AMPA glutamate receptors.
Topics: Adamantane; Animals; Anticonvulsants; Brain; Cations, Divalent; Cations, Monovalent; Convulsants; Diamines; Kainic Acid; Male; Mice; N-Methylaspartate; Neurons; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Seizures | 2004 |
AMPA receptor activation, but not the accumulation of endogenous extracellular glutamate, induces paralysis and motor neuron death in rat spinal cord in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Drug Administration Routes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Fluid; Glutamic Acid; Hindlimb; Kainic Acid; Lumbosacral Region; Male; Microdialysis; Motor Neurons; N-Methylaspartate; Paralysis; Perfusion; Potassium; Potassium Channel Blockers; Rats; Receptors, AMPA; Spinal Cord | 2004 |
Protective cap over CA1 synapses: extrasynaptic glutamate does not reach the postsynaptic density.
Topics: 4-Aminopyridine; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Dizocilpine Maleate; Drug Interactions; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Models, Neurological; N-Methylaspartate; Neural Inhibition; Neurons; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Synapses | 2004 |
Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Line; Female; Humans; Kainic Acid; Kinetics; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Nerve Fibers; Protein Subunits; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Kainic Acid; Spinal Nerve Roots | 2004 |
Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Non-Narcotic; Animals; Binding, Competitive; Electroshock; Epilepsy; Excitatory Amino Acid Agonists; Glutamic Acid; Ion Channel Gating; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Nefopam; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Sodium Channels; Synaptic Transmission; Tritium | 2004 |
The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.
Topics: 2-Amino-5-phosphonovalerate; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Ibotenic Acid; Kainic Acid; Ligands; Membrane Potentials; Models, Molecular; N-Methylaspartate; Pyrazoles; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Thermodynamics; Tritium | 2004 |
NMDA-receptor mediated efflux of N-acetylaspartate: physiological and/or pathological importance?
Topics: Amino Acids; Animals; Aspartic Acid; Cell Death; Chromatography, High Pressure Liquid; Excitatory Amino Acid Agonists; Glutathione; Kainic Acid; Male; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Organ Culture Techniques; Potassium; Propidium; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spectrophotometry, Ultraviolet | 2004 |
Endogenous tissue type plasminogen activator facilitates NMDA-induced retinal damage.
Topics: Animals; Cell Count; DNA Fragmentation; Excitatory Amino Acid Agonists; Glutamates; In Situ Nick-End Labeling; Injections; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Plasminogen Inactivators; Recombinant Proteins; Reperfusion Injury; Retina; Retinal Diseases; Retinal Ganglion Cells | 2004 |
Glutamate-evoked alterations of glial and neuronal cell morphology in the guinea pig retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Cell Size; Circadian Rhythm; Cytochalasin D; Cytoskeleton; Dicarboxylic Acids; Dopamine; Eye Proteins; Glutamic Acid; Guinea Pigs; Ischemia; Kainic Acid; N-Methylaspartate; Neuroglia; Neurons; Nocodazole; Potassium; Pyrrolidines; Receptors, AMPA; Receptors, Kainic Acid; Retina; Retinal Ganglion Cells; Synaptic Transmission; Xanthenes | 2004 |
Electrophysiological and neurochemical characterization of neurons of the medial preoptic area in Japanese quail (Coturnix japonica).
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aromatase; Coturnix; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Agonists; GABA Antagonists; Isonicotinic Acids; Kainic Acid; Male; N-Methylaspartate; Neurons; Norepinephrine; Preoptic Area; Pyridazines; Sympathomimetics | 2004 |
Activity-dependent endocytic sorting of kainate receptors to recycling or degradation pathways.
Topics: Bicuculline; Calcium; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Endocytosis; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; GluK2 Kainate Receptor; Hippocampus; Kainic Acid; Lysosomes; N-Methylaspartate; Neurons; Protein Subunits; Protein Transport; Receptors, Kainic Acid; Tetrodotoxin | 2004 |
Susceptibilities to and mechanisms of excitotoxic cell death of adult mouse inner retinal neurons in dissociated culture.
Topics: Amacrine Cells; Animals; Calcium; Cell Survival; Cells, Cultured; Drug Resistance; Excitatory Amino Acid Agonists; Glutamic Acid; Immunohistochemistry; Kainic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Neurotoxins; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Sodium; Sodium-Calcium Exchanger | 2004 |
Lateral hypothalamic signaling mechanisms underlying feeding stimulation: differential contributions of Src family tyrosine kinases to feeding triggered either by NMDA injection or by food deprivation.
Topics: Animals; Blotting, Western; Butadienes; Feeding Behavior; Focal Adhesion Kinase 2; Food Deprivation; Genistein; Hypothalamic Area, Lateral; Immunoenzyme Techniques; Immunoprecipitation; Kainic Acid; Male; N-Methylaspartate; Nitriles; Phosphorylation; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; src-Family Kinases | 2004 |
Glutamate agonists activate the hypothalamic-pituitary-adrenal axis through hypothalamic paraventricular nucleus but not through vasopressinerg neurons.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Arginine Vasopressin; Corticosterone; Excitatory Amino Acid Agonists; Glutamic Acid; Hypothalamo-Hypophyseal System; Injections, Intravenous; Kainic Acid; Male; N-Methylaspartate; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Rats; Rats, Brattleboro; Rats, Wistar; Species Specificity | 2005 |
Amyloid-beta induced cell death is independent of free radicals.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Animals, Newborn; Calcium; Carnosine; Cell Death; Cell Survival; Cerebellum; Dose-Response Relationship, Drug; Flow Cytometry; Fluorescent Dyes; Free Radicals; Indicators and Reagents; Intracellular Space; Kainic Acid; N-Methylaspartate; Neurons; Propidium; Rats; Reactive Oxygen Species; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Xanthenes | 2004 |
Increased susceptibility of glutathione peroxidase-1 transgenic mice to kainic acid-related seizure activity and hippocampal neuronal cell death.
Topics: Animals; Cell Death; Cells, Cultured; Disease Models, Animal; Epilepsy; Genetic Predisposition to Disease; Glutathione Disulfide; Glutathione Peroxidase; Hippocampus; Kainic Acid; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Organ Culture Techniques; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Up-Regulation | 2005 |
Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Apoptosis Inducing Factor; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; Benzodiazepines; Benzothiadiazines; Camptothecin; Caspase Inhibitors; Cells, Cultured; Cerebellum; Cerebral Cortex; Convulsants; Dizocilpine Maleate; Drug Resistance; Flavoproteins; Glutamic Acid; Glycine; Hippocampus; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Knockout; Mice, Mutant Strains; N-Methylaspartate; Neurons; Neurotoxins; Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Seizures | 2005 |
Nefopam inhibits calcium influx, cGMP formation, and NMDA receptor-dependent neurotoxicity following activation of voltage sensitive calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Analgesics, Non-Narcotic; Animals; Calcium; Calcium Channel Agonists; Calcium Channels; Calcium Signaling; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Kainic Acid; N-Methylaspartate; Nefopam; Neuromuscular Depolarizing Agents; Neurons; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate | 2005 |
D-aspartate and NMDA, but not L-aspartate, block AMPA receptors in rat hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; D-Aspartic Acid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hippocampus; Kainic Acid; Membrane Potentials; Microinjections; N-Methylaspartate; Neurons; Oocytes; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; RNA, Complementary; Stereoisomerism; Xenopus laevis | 2005 |
In vivo treatment with the K+ channel blocker 4-aminopyridine protects against kainate-induced neuronal cell death through activation of NMDA receptors in murine hippocampus.
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Behavior, Animal; Blotting, Western; Cell Count; Cell Death; Dizocilpine Maleate; DNA, Single-Stranded; Drug Interactions; Endodeoxyribonucleases; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Kainic Acid; Mice; N-Methylaspartate; Neurons; Potassium Channel Blockers; Proto-Oncogene Proteins c-fos; Receptors, N-Methyl-D-Aspartate; Staining and Labeling; Time Factors | 2005 |
The p53-independent nuclear translocation of cyclin G1 in degenerating neurons by ischemic and traumatic insults.
Topics: Animals; Brain Injuries; Brain Ischemia; Cell Death; Cells, Cultured; Cyclin G; Cyclin G1; Cyclins; Cycloheximide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Gene Expression Regulation; Gerbillinae; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Kainic Acid; Mice; Mice, Knockout; Microscopy, Immunoelectron; N-Methylaspartate; Nerve Degeneration; Neurons; Organic Chemicals; Phosphopyruvate Hydratase; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Time Factors; Tumor Suppressor Protein p53 | 2005 |
Effects of neurotransmitter agonists on electrocortical activity in the rat kainate model of temporal lobe epilepsy and the modulatory action of basic fibroblast growth factor.
Topics: Animals; Baclofen; Clonidine; Electroencephalography; Epilepsy, Temporal Lobe; Fibroblast Growth Factor 2; Functional Laterality; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Muscimol; N-Methylaspartate; Nerve Net; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Signal Transduction; Somatosensory Cortex | 2005 |
Physiological role for casein kinase 1 in glutamatergic synaptic transmission.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Casein Kinase 1 epsilon; Casein Kinase I; Casein Kinase Ialpha; Casein Kinase Idelta; Corpus Striatum; Egtazic Acid; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Kainic Acid; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neocortex; Nerve Tissue Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Protein Phosphatase 1; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tetrodotoxin | 2005 |
Ocular distribution after topical instillation and potential neuroprotective effect after intravitreal injection of the calcium channel blocker iganipidine.
Topics: Administration, Topical; Animals; Calcium Channel Blockers; Cell Count; Choroid; Gas Chromatography-Mass Spectrometry; Injections; Kainic Acid; Male; N-Methylaspartate; Neuroprotective Agents; Piperazines; Pyridines; Rats; Rats, Wistar; Retina; Retinal Degeneration; Retinal Ganglion Cells; Tissue Distribution; Vitreous Body | 2005 |
Voltage-sensitive and ligand-gated channels in differentiating neural stem-like cells derived from the nonhematopoietic fraction of human umbilical cord blood.
Topics: Antigens, CD34; Cell Differentiation; Cell Line; Electrophysiology; Excitatory Amino Acid Antagonists; Fetal Blood; Glycine; Humans; Immunohistochemistry; Ions; Kainic Acid; Leukocyte Common Antigens; Ligands; N-Methylaspartate; Neurons; Neurotransmitter Agents; Oligonucleotide Array Sequence Analysis; Patch-Clamp Techniques; Phenotype; Potassium; Receptors, GABA; Receptors, Glutamate; Sodium; Stem Cells; Umbilical Veins | 2005 |
Effects of N-methyl-D-aspartate glutamate receptor antagonists on oscillatory signal propagation in the guinea-pig accessory olfactory bulb slice: characterization by optical, field potential and patch clamp recordings.
Topics: Animals; Diagnostic Imaging; Dose-Response Relationship, Radiation; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neural Inhibition; Olfactory Bulb; Optics and Photonics; Patch-Clamp Techniques; Periodicity; Signal Transduction; Synaptic Transmission; Time Factors | 2005 |
Mitochondrial superoxide production and MnSOD activity after exposure to agonist and antagonists of ionotropic glutamate receptors in hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Injections; Kainic Acid; Mitochondria; N-Methylaspartate; Rats; Receptors, Kainic Acid; Superoxide Dismutase; Superoxides; Time Factors | 2005 |
Rapid control of brain aromatase activity by glutamatergic inputs.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aromatase; Brain; Coturnix; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate | 2006 |
Occurrence of bicuculline-, NMDA- and kainic acid-induced seizures in prenatally methamphetamine-exposed adult male rats.
Topics: Animals; Bicuculline; Central Nervous System Stimulants; Excitatory Amino Acid Agonists; Female; GABA Antagonists; Kainic Acid; Male; Methamphetamine; N-Methylaspartate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Seizures | 2005 |
Mapping glutamate responses in immunocytochemically identified neurons of the mouse retina.
Topics: Agmatine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Count; Excitatory Amino Acids; Kainic Acid; Lewis X Antigen; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Receptors, Glutamate; Retina; Tissue Distribution | 2006 |
Protective effect of donepezil in primary-cultured rat cortical neurons exposed to N-methyl-d-aspartate (NMDA) toxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Indans; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neuroprotective Agents; Nootropic Agents; Piperidines; Rats; Rats, Wistar; Receptors, Glutamate | 2006 |
Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity.
Topics: Animals; Brain; Brain Ischemia; Calcium; Cell Death; Cyclooxygenase 2; Dinoprostone; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Neurotoxins; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype | 2006 |
Tunicamycin decreases the probability of single-channel openings for N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Ion Channel Gating; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Probability; Quinoxalines; Rats; Rats, Wistar; Reaction Time; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tunicamycin | 2006 |
Sodium- and magnesium-valproate in vivo modulate glutamatergic and GABAergic synapses in the medial prefrontal cortex.
Topics: Action Potentials; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Prefrontal Cortex; Quisqualic Acid; Rats; Rats, Wistar; Salts; Sodium; Synapses; Valproic Acid | 2006 |
Role of glutamate receptors in the ventromedial hypothalamus in the regulation of female rat sexual behaviors I. Behavioral effects of glutamate and its selective receptor agonists AMPA, NMDA and kainate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Female; Hypothalamus; Kainic Acid; N-Methylaspartate; Ovariectomy; Rats; Rats, Long-Evans; Receptors, Glutamate; Sexual Behavior, Animal | 2006 |
Contribution of spinal glutamatergic receptors to the antinociception caused by agmatine in mice.
Topics: Agmatine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Neuroprotective Agents; Nociceptors; Pain; Receptors, Glutamate; Spinal Cord | 2006 |
NMDA and non-NMDA receptors stimulation causes differential oxidative stress in rat cortical slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence | 2006 |
NF-kappaB modulators from Valeriana officinalis.
Topics: Astrocytes; Coculture Techniques; HeLa Cells; Humans; Kainic Acid; N-Methylaspartate; Neurons; NF-kappa B; Plant Extracts; Valerian | 2006 |
A potent non-monoaminergic paradoxical sleep inhibitory system: a reverse microdialysis and single-unit recording study.
Topics: Action Potentials; Animals; Biogenic Monoamines; Brain Chemistry; Carbachol; Cats; Cholinergic Agonists; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Excitatory Amino Acid Agonists; GABA Agonists; Kainic Acid; Muscimol; N-Methylaspartate; Neural Inhibition; Periaqueductal Gray; Sleep, REM; Tegmentum Mesencephali; Wakefulness | 2006 |
Mechanisms of the blockade of glutamate channel receptors: significance for structural and physiological investigations.
Topics: Animals; Animals, Newborn; Arecoline; Diamines; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Ion Channel Gating; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Glutamate; Tremor | 2007 |
Hippocampal seizure resistance and reduced neuronal excitotoxicity in mice lacking the Cav2.3 E/R-type voltage-gated calcium channel.
Topics: Animals; Calcium Channels, R-Type; Cation Transport Proteins; Electroencephalography; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Seizures | 2007 |
Differential regulation of glutamate receptor-mediated BDNF mRNA expression in the cerebellum and its defects in stargazer mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Calcium Channels; Cells, Cultured; Cerebellum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; In Situ Hybridization; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; N-Methylaspartate; Neurons; Protein Binding; Quinoxalines; Receptors, Glutamate; RNA, Messenger; Time Factors | 2007 |
The role of defensins in the excitability of the peripheral vestibular system in the frog: evidence for the presence of communication between the immune and nervous systems.
Topics: Acetylcholine; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha-Defensins; Animals; Atropine; Cholinergic Antagonists; Cycloleucine; Defensins; Dose-Response Relationship, Drug; Glutamic Acid; Humans; Immune System; In Vitro Techniques; Inflammation; Kainic Acid; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neuroimmunomodulation; Neurons, Afferent; Rabbits; Rana temporaria; Receptors, Cholinergic; Receptors, Glutamate; Receptors, Opioid; Semicircular Canals; Synaptic Transmission; Vestibule, Labyrinth | 2007 |
Decursinol and decursin protect primary cultured rat cortical cells from glutamate-induced neurotoxicity.
Topics: Angelica; Animals; Antioxidants; Benzopyrans; Butyrates; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Glutathione; Glutathione Peroxidase; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2007 |
Modulation of extracellular proton fluxes from retinal horizontal cells of the catfish by depolarization and glutamate.
Topics: Animals; Calcium; Catfishes; Excitatory Amino Acid Agonists; Glutamic Acid; Hydrogen-Ion Concentration; Kainic Acid; Membrane Potentials; Microelectrodes; N-Methylaspartate; Patch-Clamp Techniques; Potassium; Protons; Retinal Horizontal Cells; Sodium-Hydrogen Exchangers | 2007 |
Modulation of interleukin-6 and matrix metalloproteinase 2 expression in human fibroblast-like synoviocytes by functional ionotropic glutamate receptors.
Topics: Adult; Animals; Calcium; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Fibroblasts; Gene Expression; GluK2 Kainate Receptor; Glutamic Acid; Hindlimb; Humans; Interleukin-6; Kainic Acid; Male; Matrix Metalloproteinase 2; Menisci, Tibial; Middle Aged; N-Methylaspartate; Rats; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; RNA, Messenger; Synovial Membrane; Tissue Inhibitor of Metalloproteinases | 2007 |
Effect of exogenous glutamate and N-Methyl-D-aspartic acid on spontaneous activity of isolated human ureter.
Topics: Adult; Aged; Cycloleucine; Female; Glutamic Acid; Humans; In Vitro Techniques; Kainic Acid; Male; Middle Aged; Muscle, Smooth; N-Methylaspartate; Ureter | 2007 |
Different transmitter transients underlie presynaptic cell type specificity of GABAA,slow and GABAA,fast.
Topics: Action Potentials; Animals; GABA Agonists; Interneurons; Kainic Acid; Kinetics; Models, Neurological; N-Methylaspartate; Neocortex; Neural Inhibition; Patch-Clamp Techniques; Presynaptic Terminals; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Synapses; Zolpidem | 2007 |
A synthetic kainoid, (2S,3R,4R)-3-carboxymethyl-4-(phenylthio)pyrrolidine-2-carboxylic acid (PSPA-1) serves as a novel anti-allodynic agent for neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Hyperalgesia; Immunohistochemistry; Inflammation; Kainic Acid; Mice; Mononeuropathies; N-Methylaspartate; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Pain; Spinal Cord; Time Factors | 2007 |
Acute infusion of nicotine impairs nNOS-dependent reactivity of cerebral arterioles via an increase in oxidative stress.
Topics: Animals; Antioxidants; Arterioles; Brain; Cyclic N-Oxides; Dose-Response Relationship, Drug; Infusions, Intravenous; Kainic Acid; Male; N-Methylaspartate; Nicotine; Nicotinic Agonists; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroglycerin; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spin Labels; Superoxides; Vasodilation; Vasodilator Agents | 2007 |
Excitotoxicity mediated by non-NMDA receptors causes distal axonopathy in long-term cultured spinal motor neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Axons; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Microtubule-Associated Proteins; Motor Neurons; N-Methylaspartate; Nerve Tissue Proteins; Neurofilament Proteins; Rats; Receptors, Glutamate; Spinal Cord; Time Factors | 2007 |
nNOS-dependent reactivity of cerebral arterioles in Type 1 diabetes.
Topics: Animals; Cerebral Arteries; Diabetes Mellitus, Type 1; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Kainic Acid; Male; N-Methylaspartate; Nitric Oxide Synthase; Nitroglycerin; Rats; Rats, Sprague-Dawley; Streptozocin; Superoxides | 2007 |
A highly sulfated chondroitin sulfate preparation, CS-E, prevents excitatory amino acid-induced neuronal cell death.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Caspase 3; Cell Death; Cell Survival; Chondroitin Sulfates; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neocortex; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Phosphorylation; Polyelectrolytes; Polymers; Pregnancy; Rats; Rats, Sprague-Dawley; Tyrosine | 2008 |
Expression of osteopontin in the rat retina: effects of excitotoxic and ischemic injuries.
Topics: Animals; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique, Indirect; Immunoenzyme Techniques; Kainic Acid; N-Methylaspartate; Osteopontin; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retina; Retinal Diseases; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thy-1 Antigens; Transcription Factor Brn-3 | 2008 |
TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury.
Topics: Animals; Brain Ischemia; Cell Death; Cytoprotection; Erythropoietin; Excitatory Amino Acid Agonists; Gene Expression Profiling; Kainic Acid; Male; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Oligonucleotide Array Sequence Analysis; Receptors, Erythropoietin; Receptors, Tumor Necrosis Factor, Type I; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2008 |
NMDA and GABA B receptors are involved in controlling nematocyst discharge in hydra.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Dose-Response Relationship, Drug; Epinephrine; Glutamic Acid; Glycine; Hydra; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Receptors, GABA-B; Serotonin | 2008 |
Chloride-dependent acute excitotoxicity in adult rat retinal ganglion cells.
Topics: Animals; Bicuculline; Chelating Agents; Chlorides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Eye; GABA Antagonists; Glycine Agents; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Papilledema; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Sodium; Strychnine | 2008 |
Kainate and metabolic perturbation mimicking spinal injury differentially contribute to early damage of locomotor networks in the in vitro neonatal rat spinal cord.
Topics: Action Potentials; Animals; Animals, Newborn; Cell Death; Culture Media; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Agonists; In Vitro Techniques; Kainic Acid; Locomotion; Models, Neurological; N-Methylaspartate; Nerve Net; Neurotoxins; Periodicity; Rats; Rats, Wistar; Receptors, Kainic Acid; Serotonin; Spinal Cord; Spinal Cord Injuries; Time Factors | 2008 |
[Apoptosis and its receptor selective pathways during neurotoxic action of glutamate].
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Necrosis; Neurons; Rats; Rats, Wistar; Receptors, Glutamate; Tumor Suppressor Protein p53 | 2008 |
NMDA-induced seizure intensity is enhanced in COX-2 deficient mice.
Topics: Animals; Cyclooxygenase 2; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fluoresceins; Gas Chromatography-Mass Spectrometry; Hexachlorocyclohexane; Insecticides; Kainic Acid; Male; Mice; Mice, Knockout; N-Methylaspartate; Organic Chemicals; Prostaglandins; Seizures | 2008 |
Bidirectional regulation of kainate receptor surface expression in hippocampal neurons.
Topics: Animals; Cell Membrane; Gene Expression Regulation; GluK2 Kainate Receptor; Glutamic Acid; Hippocampus; Hydrogen-Ion Concentration; Kainic Acid; Microscopy, Confocal; Models, Biological; N-Methylaspartate; Neurons; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Sindbis Virus | 2008 |
N-Methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors involved in the induction of sedative effects under an acute stress in neonatal chicks.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chickens; Excitatory Amino Acid Agonists; Glutamic Acid; Immobility Response, Tonic; Kainic Acid; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Stress, Psychological | 2009 |
Rescue of neurons from ischemic injury by peroxisome proliferator-activated receptor-gamma requires a novel essential cofactor LMO4.
Topics: Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Death; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Embryo, Mammalian; Gene Expression Regulation; Glucose; Homeodomain Proteins; Hypoglycemic Agents; Immunoprecipitation; Infarction, Middle Cerebral Artery; Kainic Acid; LIM Domain Proteins; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Oxygen; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR gamma; Rosiglitazone; Signal Transduction; Superoxide Dismutase; Thiazolidinediones; Trans-Activators; Transcription Factors | 2008 |
NMDA preconditioning and neuroprotection in vivo: delayed onset of kainic acid-induced neurodegeneration and c-Fos attenuation in CA3a neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cell Death; Dizocilpine Maleate; Female; Gene Expression; Genes, fos; Hippocampus; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 2009 |
GABA(A)- and AMPA-like receptors modulate the activity of an identified neuron within the central pattern generator of the pond snail Lymnaea stagnalis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Clocks; Brain; Excitatory Amino Acid Agonists; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Lymnaea; Membrane Potentials; N-Methylaspartate; Neural Inhibition; Neurons; Picrotoxin; Receptors, AMPA; Receptors, GABA-A; Respiration | 2009 |
Apoptosis and the receptor specificity of its mechanisms during the neurotoxic action of glutamate.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Necrosis; Neurons; Rats; Rats, Wistar; Receptors, Glutamate; Tumor Suppressor Protein p53 | 2009 |
Protein SUMOylation modulates calcium influx and glutamate release from presynaptic terminals.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Central Nervous System Stimulants; Endopeptidases; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Potassium Chloride; Presynaptic Terminals; Rats; Rats, Wistar; Recombinant Proteins; Small Ubiquitin-Related Modifier Proteins; SUMO-1 Protein; Synaptic Transmission; Synaptosomes | 2009 |
Unconjugated TAT carrier peptide protects against excitotoxicity.
Topics: Age Factors; Animals; Animals, Newborn; Brain Ischemia; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; tat Gene Products, Human Immunodeficiency Virus; Time Factors | 2009 |
Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.
Topics: Animals; Calcium Signaling; Chick Embryo; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Malonates; Mitochondria; Motor Neuron Disease; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Organ Culture Techniques; Propionates; Riluzole; Spinal Cord | 2009 |
Effects of TRH and its analogues on primary cortical neuronal cell damage induced by various excitotoxic, necrotic and apoptotic agents.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Kainic Acid; Mice; Mitogen-Activated Protein Kinases; N-Methylaspartate; Necrosis; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Pregnancy; Proto-Oncogene Proteins c-akt; Quisqualic Acid; Staurosporine; Thyrotropin-Releasing Hormone | 2009 |
Cholesterol depletion inhibits electrophysiological changes induced by anoxia in CA1 region of rat hippocampal slices.
Topics: Action Potentials; Analysis of Variance; Animals; beta-Cyclodextrins; CA1 Region, Hippocampal; Cholesterol; Electrophysiology; Excitatory Postsynaptic Potentials; Glucose; Hypoxia; Kainic Acid; Male; Membrane Potentials; N-Methylaspartate; Neurons; Organ Culture Techniques; Rats; Rats, Wistar; Time Factors | 2009 |
Ibuprofen for neuroprotection after cerebral ischemia.
Topics: Animals; Astrocytes; Brain Ischemia; Cell Death; Cells, Cultured; Excitatory Amino Acid Agonists; Ibuprofen; Kainic Acid; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Neuroprotective Agents | 2010 |
Specificity of action of epileptogenic agents in diazepam-tolerant rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Diazepam; Excitatory Amino Acid Agonists; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 2009 |
Rapid and noninvasive imaging of retinal ganglion cells in live mouse models of glaucoma.
Topics: Animals; Cell Count; Cell Death; Disease Models, Animal; Fluorescence; Fundus Oculi; Glaucoma; Green Fluorescent Proteins; Intraocular Pressure; Kainic Acid; Mice; Molecular Imaging; N-Methylaspartate; Neurotoxins; Retinal Ganglion Cells; Thy-1 Antigens; Time Factors | 2010 |
Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats.
Topics: Anacardiaceae; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Epilepsy; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2010 |
Effects of early postnatal caffeine exposure on seizure susceptibility of rats are age- and model-dependent.
Topics: Age Factors; Analysis of Variance; Animals; Caffeine; Convulsants; Disease Susceptibility; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Kainic Acid; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Seizures; Time Factors | 2010 |
Effects of Z-338, a novel gastroprokinetic agent, on the actions of excitatory and inhibitory neurotransmitters on neurons in area postrema.
Topics: Adenosine Triphosphate; Animals; Area Postrema; Benzamides; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Ganglionic Stimulants; Gastrointestinal Agents; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Kainic Acid; Male; N-Methylaspartate; Neurons; Nicotine; Patch-Clamp Techniques; Rats; Rats, Wistar; Thiazoles; Vagus Nerve | 2010 |
Gamma band unit activity and population responses in the pedunculopontine nucleus.
Topics: Action Potentials; Animals; Carbachol; Electroencephalography; Electrophysiological Phenomena; Excitatory Amino Acid Agonists; Female; Kainic Acid; Membrane Potentials; Muscarinic Agonists; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pedunculopontine Tegmental Nucleus; Potassium Channel Blockers; Potassium Channels; Pregnancy; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetrodotoxin; Theta Rhythm | 2010 |
Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice.
Topics: Animals; Anticonvulsants; Berberine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Rotarod Performance Test; Seizures | 2010 |
Retinal input to efferent target amacrine cells in the avian retina.
Topics: Action Potentials; Amacrine Cells; Animals; Chickens; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agents; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; In Vitro Techniques; Isoquinolines; Kainic Acid; Mesencephalon; N-Methylaspartate; Neurons; Nicotinic Agonists; Parvalbumins; Patch-Clamp Techniques; Receptors, Neurotransmitter; Retina; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Vesicular Glutamate Transport Protein 2; Visual Pathways | 2010 |
Characterization of GFP-tagged GnRH-containing terminalis neurons in transgenic zebrafish.
Topics: Action Potentials; Animals; Animals, Genetically Modified; Axons; Cell Membrane; Gene Expression Regulation; Glutamic Acid; Gonadotropin-Releasing Hormone; Green Fluorescent Proteins; Kainic Acid; N-Methylaspartate; Neurons; Olfactory Bulb; Patch-Clamp Techniques; Receptors, Glutamate; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Zebrafish | 2011 |
Curcumin protects against NMDA-induced toxicity: a possible role for NR2A subunit.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Blotting, Western; Calcium; Cells, Cultured; Curcumin; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; N-Methylaspartate; Neuroprotective Agents; Patch-Clamp Techniques; Pregnancy; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Retina; Time Factors | 2011 |
Involvement of the thalamic parafascicular nucleus in mesial temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Biophysical Phenomena; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Potentials, Somatosensory; Excitatory Amino Acid Antagonists; Functional Laterality; GABA-A Receptor Agonists; Hippocampus; Intralaminar Thalamic Nuclei; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Muscimol; N-Methylaspartate; Neurons; Statistics, Nonparametric; Time Factors; Wakefulness | 2010 |
Myelin-associated glycoprotein protects neurons from excitotoxicity.
Topics: Animals; Antibodies; Cells, Cultured; Disease Models, Animal; Disease Susceptibility; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hippocampus; Humans; In Vitro Techniques; Integrin beta Chains; Kainic Acid; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Proteins; Myelin-Associated Glycoprotein; N-Methylaspartate; Neurons; Peptide Fragments; Phosphoinositide Phospholipase C; Receptors, Cell Surface; Seizures; Signal Transduction; Tubulin | 2011 |
Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae).
Topics: Animals; Anticonvulsants; Bicuculline; Chi-Square Distribution; Disease Models, Animal; Dose-Response Relationship, Drug; Fabaceae; Flowers; Heterocyclic Compounds, 4 or More Rings; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Reaction Time; Seizures | 2011 |
Cortical and hippocampal EEG effects of neurotransmitter agonists in spontaneously hypertensive vs. kainate-treated rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Baclofen; Clonidine; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Frontal Lobe; Hippocampus; Hypertension; Kainic Acid; Muscimol; N-Methylaspartate; Neurotransmitter Agents; Rats; Rats, Inbred SHR; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate | 2011 |
Responses of developing pedunculopontine neurons to glutamate receptor agonists.
Topics: Animals; Animals, Newborn; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Kainic Acid; Models, Animal; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pedunculopontine Tegmental Nucleus; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Sleep, REM | 2011 |
Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Ataxia; Cerebral Cortex; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Rats; Rats, Wistar; Reaction Time; Seizures; Spider Venoms; Synaptosomes; Tritium | 2011 |
Role of retinal glial cell glutamate transporters in retinal ganglion cell survival following stimulation of NMDA receptor.
Topics: Acetophenones; Animals; Animals, Newborn; Benzopyrans; Blotting, Western; Cell Survival; Cells, Cultured; Coculture Techniques; Culture Media; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Kainic Acid; N-Methylaspartate; Neuroglia; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; RNA, Messenger | 2012 |
Developmental changes in glutamatergic fast synaptic neurotransmission in the dorsal subcoeruleus nucleus.
Topics: Animals; Animals, Newborn; Cell Culture Techniques; Electric Stimulation; Excitatory Amino Acid Agonists; Kainic Acid; Locus Coeruleus; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Sleep, REM; Synaptic Transmission; Thalamus | 2012 |
Functional role of astrocyte glutamate receptors and carbon monoxide in cerebral vasodilation response to glutamate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Arterioles; Astrocytes; Carbon Monoxide; Cells, Cultured; Cerebrovascular Circulation; Female; Glutamates; Heme Oxygenase (Decyclizing); In Vitro Techniques; Kainic Acid; Male; Models, Animal; N-Methylaspartate; Receptors, Glutamate; Swine; Vasodilation | 2012 |
In vitro studies of the influence of glutamatergic agonists on the Na+,K(+)-ATPase and K(+)-p-nitrophenylphosphatase activities in the hippocampus and frontal cortex of rats.
Topics: 4-Nitrophenylphosphatase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Frontal Lobe; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Synaptic Transmission | 2012 |
New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups.
Topics: Animals; Cerebellum; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Indoles; Interneurons; Kainic Acid; Ligands; N-Methylaspartate; Nerve Tissue Proteins; Nitro Compounds; Photolysis; Protein Isoforms; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, Ionotropic Glutamate; Synaptic Transmission; Ultraviolet Rays | 2012 |
NMDA receptors in the medial prefrontal cortex and the dorsal hippocampus regulate methamphetamine-induced hyperactivity and extracellular amino acid release in mice.
Topics: Amino Acids; Animals; Blotting, Western; Central Nervous System Stimulants; Excitatory Amino Acid Agonists; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Hyperkinesis; Kainic Acid; Male; Methamphetamine; Mice; Microdialysis; N-Methylaspartate; Neural Pathways; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Vesicular Glutamate Transport Protein 2 | 2012 |
[Inhibitory regulation of glutamate receptors in the frog motoneuron].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Evoked Potentials; Excitatory Amino Acids; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Kainic Acid; Microelectrodes; Motor Neurons; N-Methylaspartate; Organ Culture Techniques; Poisons; Pyridazines; Rana ridibunda; Receptors, Ionotropic Glutamate; Spinal Cord; Strychnine | 2012 |
Na+,K+-ATPase functionally interacts with the plasma membrane Na+,Ca2+ exchanger to prevent Ca2+ overload and neuronal apoptosis in excitotoxic stress.
Topics: Animals; Apoptosis; Binding Sites; Calcium; Cell Culture Techniques; Cell Membrane; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Electrical Synapses; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Immunohistochemistry; Kainic Acid; Microscopy, Confocal; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Neuroprotective Agents; Ouabain; Patch-Clamp Techniques; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Sodium-Calcium Exchanger; Sodium-Potassium-Exchanging ATPase | 2012 |
Effect of somatostatin on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in the neurons of rat brain.
Topics: Animals; Brain; Calcium; Corticotropin-Like Intermediate Lobe Peptide; Drug Synergism; gamma-Aminobutyric Acid; Ion Transport; Kainic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Receptors, AMPA; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Somatostatin; Synaptic Transmission; Synaptosomes | 2012 |
Changes in brain cortex sensitivity to epileptogens under conditions of ketogenic diet.
Topics: Animals; Cerebral Cortex; Diet, Ketogenic; Epilepsy; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Penicillin G; Rats; Rats, Wistar; Strychnine | 2013 |
Magnesium lithospermate B protects neurons from N-methyl-D-aspartic acid injury and attenuates kainic acid-induced neurodegeration in FVB mice.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt | 2013 |
Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration.
Topics: Animals; Brain; Disks Large Homolog 4 Protein; Glutamic Acid; Guanylate Kinases; Kainic Acid; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Knockout; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Synapses | 2013 |
Astrogliosis is a possible player in preventing delayed neuronal death.
Topics: Animals; Astrocytes; Biomarkers; Brain Injuries; Cell Communication; Cell Death; Cerebral Cortex; Excitatory Amino Acid Transporter 2; Glial Fibrillary Acidic Protein; Gliosis; Glutamate-Ammonia Ligase; Kainic Acid; Male; N-Methylaspartate; Neurons; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; S100 Calcium Binding Protein beta Subunit | 2014 |
Combined blockade of NMDA and AMPA receptors prevents acute kainate seizures and chronic kainate lethality in rats.
Topics: Adamantane; Amines; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Injections, Intramuscular; Kainic Acid; Male; Memantine; N-Methylaspartate; Neuroprotective Agents; Pentylenetetrazole; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Survival Analysis | 2014 |
Characterization of Human Hippocampal Neural Stem/Progenitor Cells and Their Application to Physiologically Relevant Assays for Multiple Ionotropic Glutamate Receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Calcium; Cell Differentiation; Cell Line; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electrophysiology; Gene Expression Regulation; Hippocampus; Humans; Kainic Acid; N-Methylaspartate; Neural Stem Cells; Quinoxalines; Receptors, Ionotropic Glutamate | 2014 |
Ketone bodies attenuate excitotoxic cell injury in the rat hippocampal slice under conditions of reduced glucose availability.
Topics: Action Potentials; Animals; Excitatory Amino Acid Agonists; Glucose; Hippocampus; Kainic Acid; Ketone Bodies; Long-Term Potentiation; Male; Microelectrodes; N-Methylaspartate; Rats, Sprague-Dawley; Synaptic Transmission; Tissue Culture Techniques | 2015 |
Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input.
Topics: Animals; Biological Transport, Active; Biotinylation; Calcium; Cell Membrane; Cells, Cultured; Chick Embryo; Chickens; Culture Media, Conditioned; Ependymoglial Cells; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression Profiling; Glutamic Acid; Kainic Acid; N-Methylaspartate; Protein Kinase C; Protein Kinase Inhibitors; Retina; RNA, Messenger; Tetradecanoylphorbol Acetate | 2015 |
FTY720 attenuates excitotoxicity and neuroinflammation.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Brain Diseases; Cell Death; Cells, Cultured; Cerebellum; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fingolimod Hydrochloride; In Vitro Techniques; Kainic Acid; L-Lactate Dehydrogenase (Cytochrome); Male; N-Methylaspartate; Neurons; Organ Culture Techniques; Phosphorylation; Rats; Rats, Sprague-Dawley; Time Factors | 2015 |
Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene.
Topics: Animals; Carrier Proteins; Cells, Cultured; Central Nervous System Depressants; Electric Capacitance; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Homer Scaffolding Proteins; Kainic Acid; Membrane Potentials; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate | 2016 |
Synaptic mechanisms shaping delay-tuned combination-sensitivity in the auditory thalamus of mustached bats.
Topics: Acoustic Stimulation; Acoustics; Animals; Auditory Cortex; Chiroptera; Echolocation; Electrodes; gamma-Aminobutyric Acid; Geniculate Bodies; Glutamic Acid; Inferior Colliculi; Kainic Acid; N-Methylaspartate; Neurons; Reaction Time; Signal Processing, Computer-Assisted; Thalamus; Time Factors | 2016 |
A study of methylprednisolone neuroprotection against acute injury to the rat spinal cord in vitro.
Topics: Animals; Animals, Newborn; Immunohistochemistry; Kainic Acid; Lumbar Vertebrae; Membrane Potentials; Methylprednisolone; Motor Activity; N-Methylaspartate; Neural Pathways; Neuroglia; Neurons; Neuroprotective Agents; Neurotransmitter Agents; Rats, Wistar; Serotonin; Spinal Cord Injuries; White Matter | 2016 |
Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Ciliary Neurotrophic Factor; Kainic Acid; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurogenesis; Retinal Ganglion Cells; Uncoupling Protein 2 | 2016 |
Non-genomic action of vitamin D3 on N-methyl-D-aspartate and kainate receptor-mediated actions in juvenile gonadotrophin-releasing hormone neurons.
Topics: Animals; Cholecalciferol; Epigenesis, Genetic; Female; Gonadotropin-Releasing Hormone; Green Fluorescent Proteins; In Vitro Techniques; Kainic Acid; Male; Mice, Transgenic; N-Methylaspartate; Nerve Tissue Proteins; Neurogenesis; Neurons; Patch-Clamp Techniques; Preoptic Area; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Synaptic Potentials | 2017 |
Chimeric Glutamate Receptor Subunits Reveal the Transmembrane Domain Is Sufficient for NMDA Receptor Pore Properties but Some Positive Allosteric Modulators Require Additional Domains.
Topics: Allosteric Regulation; Animals; Arachidonic Acid; Calcium; Dimerization; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Excitatory Amino Acid Agents; Excitatory Amino Acid Agonists; Green Fluorescent Proteins; HEK293 Cells; Humans; Hydroxycholesterols; Kainic Acid; Membrane Potentials; Models, Molecular; N-Methylaspartate; Patch-Clamp Techniques; Pregnenolone; Protein Domains; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Transfection | 2016 |
Glutamatergic modulation of noradrenaline release in the rat median preoptic area.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Male; Microdialysis; N-Methylaspartate; Norepinephrine; Preoptic Area; Quisqualic Acid; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2017 |
Excessive activation of ionotropic glutamate receptors induces apoptotic hair-cell death independent of afferent and efferent innervation.
Topics: Animals; Apoptosis; Glutamic Acid; Hair Cells, Auditory; Kainic Acid; Larva; N-Methylaspartate; Neurons, Afferent; Neurons, Efferent; Receptors, AMPA; Receptors, Ionotropic Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Zebrafish | 2017 |
Glutamate-dependent ectodomain shedding of neuregulin-1 type II precursors in rat forebrain neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; ADAM17 Protein; Animals; Blotting, Western; Cell Membrane; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Glutamates; Kainic Acid; N-Methylaspartate; Neuregulin-1; Neurons; Prosencephalon; Protein Kinase C; Protein Precursors; Proteolysis; Rats, Sprague-Dawley; Serotonin | 2017 |
CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Excitatory Amino Acid Antagonists; Guanylate Kinases; Hippocampus; Kainic Acid; Membrane Proteins; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Piperidines; Post-Synaptic Density; Protein Serine-Threonine Kinases; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Seizures; Tissue Culture Techniques | 2017 |
Insulin-like growth factor 1 promotes cochlear synapse regeneration after excitotoxic trauma in vitro.
Topics: Animals; Cochlea; Disease Models, Animal; Hair Cells, Auditory, Inner; Hearing Loss, Sensorineural; Humans; In Vitro Techniques; Insulin-Like Growth Factor I; Kainic Acid; Mice; Mice, Inbred ICR; N-Methylaspartate; Nerve Regeneration; Ototoxicity; Receptor, IGF Type 1; Spiral Ganglion; Synapses | 2019 |
Soluble Epoxide Hydrolase Inhibition Attenuates Excitotoxicity Involving 14,15-Epoxyeicosatrienoic Acid-Mediated Astrocytic Survival and Plasticity to Preserve Glutamate Homeostasis.
Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Astrocytes; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Epoxide Hydrolases; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hippocampus; Homeostasis; Kainic Acid; Lauric Acids; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 8; Models, Biological; N-Methylaspartate; Neuroglia; Neuronal Plasticity; Neurons; Neurotoxins; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Solubility | 2019 |
Glutamatergic activation of A1 and A2 noradrenergic neurons in the rat brain stem.
Topics: Adrenergic Neurons; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Stem; Excitatory Amino Acid Agents; Female; Immunohistochemistry; Kainic Acid; N-Methylaspartate; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Tyrosine 3-Monooxygenase | 2019 |
A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling.
Topics: Animals; Bicuculline; Cells, Cultured; GABA-A Receptor Antagonists; Glutamic Acid; Glycine; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; MicroRNAs; N-Methylaspartate; Neurotoxins; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Ribonuclease III; Seizures; Signal Transduction; Specific Pathogen-Free Organisms; Subcellular Fractions; Transcriptome; Up-Regulation | 2020 |
Deleterious Effect of NMDA Plus Kainate on the Inner Retinal Cells and Ganglion Cell Projection of the Mouse.
Topics: Amacrine Cells; Animals; Cells, Cultured; Excitatory Amino Acid Agonists; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Photoreceptor Cells; Retinal Ganglion Cells; Visual Pathways | 2020 |
Melatonin Suppresses the Kainate Receptor-Mediated Excitation on Gonadotropin-Releasing Hormone Neurons in Female and Male Prepubertal Mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Excitatory Amino Acid Agonists; Female; Gonadotropin-Releasing Hormone; Green Fluorescent Proteins; Kainic Acid; Male; Melatonin; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Neurons; Pertussis Toxin; Puberty; Receptors, Kainic Acid | 2020 |
A human stem cell-derived test system for agents modifying neuronal N-methyl-D-aspartate-type glutamate receptor Ca
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Kainic Acid; N-Methylaspartate; Neural Stem Cells; Neurons; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2021 |
The continually evolving role of NMDA receptors in neurobiology and disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Kainic Acid; N-Methylaspartate; Neurobiology; Receptors, N-Methyl-D-Aspartate | 2022 |
Rutin prevents seizures in kainic acid-treated rats: evidence of glutamate levels, inflammation and neuronal loss modulation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport Systems; Animals; Anti-Inflammatory Agents; Carbamazepine; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Hippocampus; HMGB1 Protein; Inflammation; Interleukin-10; Interleukin-1beta; Interleukin-6; Kainic Acid; N-Methylaspartate; Rats; Receptors, Interleukin-1; Rutin; Seizures; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2022 |