n-methylaspartate has been researched along with glycine in 638 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 54 (8.46) | 18.7374 |
| 1990's | 371 (58.15) | 18.2507 |
| 2000's | 162 (25.39) | 29.6817 |
| 2010's | 40 (6.27) | 24.3611 |
| 2020's | 11 (1.72) | 2.80 |
| Authors | Studies |
|---|---|
| Bräuner-Osborne, H; Egebjerg, J; Krogsgaard-Larsen, P; Madsen, U; Nielsen, EO | 1 |
| Aoshima, H; Inoue, Y; Tanaka, D | 1 |
| Nomura, Y; Tohda, M; Urushihara, H | 1 |
| Bowery, NG; Fletcher, AE; Price, GW; Ransom, R; Wilkin, GP; Wong, EH | 1 |
| Carbone, S; Moguilevsky, JA; Otero Losada, ME; Szwarcfarb, B | 1 |
| Helm, SW; Henzi, V; MacDermott, AB; Reichling, DB | 1 |
| Kelly, JB; Wu, SH | 2 |
| Burnashev, N; Herb, A; Higuchi, M; Lomeli, H; Monyer, H; Sakmann, B; Schoepfer, R; Seeburg, PH; Sprengel, R | 1 |
| Davidoff, RA; Hackman, JC; Holohean, AM; Shope, SB | 1 |
| Huettner, JE; Koroshetz, WJ; Rees, AH; Swartz, KJ | 1 |
| Cler, JA; Garland, DJ; Hood, WF; Iyengar, S; Mick, SJ; Monahan, JB; Rao, TS; Sun, ET; Vazquez, ML | 1 |
| Akaike, N; Kakehata, S; Nakagawa, T; Takasaka, T | 1 |
| Besser, GM; Costa, A; Forsling, ML; Grossman, A; Hucks, D; Yasin, SA | 1 |
| Barnard, EA; Usherwood, PN | 1 |
| Bowen, DM; Foster, AC; Francis, PT; Middlemiss, DN; Pangalos, MN; Pearson, RC | 1 |
| Calligaro, DO; Heinz, LJ; Lunn, WH; O'Malley, PJ; Salhoff, CR; Schoepp, DD; Vasileff, RT | 1 |
| Lerma, J; Martín del Río, R | 1 |
| Bobichon, C; Cordi, A; Curutchet, P; de Carvalho, LP; Guet, T; Lambolez, B; Lepagnol, JM; Moreau, C; Randle, JC | 1 |
| Donevan, SD; Jones, SM; Rogawski, MA | 1 |
| Peoples, RW; Weight, FF | 1 |
| Balázs, R; Hack, N; Kumar, KN; Michaelis, E; Resink, A; Van der Valk, JB | 1 |
| Beaucourt, JP; Chicheportiche, R; Guiramand, J; Kamenka, JM; Ponchant, M | 1 |
| Lodge, D; Millar, JD; Pralong, E | 1 |
| Fink, K; Göthert, M; Schultheiss, R | 1 |
| Randic, M; Rusin, KI; Ryu, PD | 1 |
| Compton, RP; Cordi, AA; Dappen, MS; Gray, NM; Hood, WF; Lanthorn, TH; Monahan, JB; Watson, GB | 1 |
| Barun, S; Dalkara, T; Erdemli, G; Onur, R | 1 |
| Lazarewicz, JW; Puka, M; Salińska, E | 1 |
| Albuquerque, EX; Ujihara, H | 2 |
| Fredholm, BB; Hu, PS; Jin, S | 1 |
| Baker, R; Carling, RW; Chan, T; Foster, AC; Grimwood, S; Leeson, PD; Moore, KW; Moseley, AM; Smith, JD; Stevenson, G | 1 |
| Hoffman, PL; Iorio, KR; Reinlib, L; Tabakoff, B | 1 |
| Edamura, M; Stein, RB; Wheatley, M | 1 |
| Budai, D; Larson, AA; Wilcox, GL | 1 |
| Aizenman, E; Reynolds, IJ | 1 |
| Deutsch, SI; Handerson, H; Hashtroudi, S; Herting, RL; Schwartz, BL | 1 |
| Albensi, BC; Artman, LD; Jackson, H; Jasys, VJ; Mueller, AL; Nemeth, EF; Parks, TN; Saccomano, NA; Volkmann, RA | 1 |
| Baron, BM; Edwards, ML; Reynolds, IJ | 1 |
| Connick, JH; Stone, TW | 1 |
| Dure, LS; Penney, JB; Young, AB | 1 |
| Lipton, SA; Sucher, NJ | 1 |
| Akaike, N; Ikemoto, Y; Wakamori, M | 1 |
| Akaike, N; Ito, C; Wakamori, M | 1 |
| Klunk, WE; McClure, RJ; Pettegrew, JW | 1 |
| Chabert, R; Eybalin, M; Ladrech, S; Puel, JL; Pujol, R | 1 |
| Kemp, JA; Priestley, T | 1 |
| Choi, DW; Koh, JY | 1 |
| Cull-Candy, SG; Farrant, M | 1 |
| Choi, DW; Regan, RF | 1 |
| Costa, E; de Costa, BR; Di Chiro, G; Ferrarese, C; Fulham, MJ; Guidotti, A; Miletich, RS; Rice, KC | 1 |
| Morita, Y; Nishimura, S; Sorimachi, M | 1 |
| Glantz, RM; Pfeiffer-Linn, C | 1 |
| Fink, K; Göthert, M | 1 |
| Albuquerque, EX; Alkondon, M; Aronstam, RS; Costa, AC; Radhakrishnan, V | 1 |
| Bennett, MV; Lerma, J; Zukin, RS | 1 |
| Cull-Candy, SG; Traynelis, SF | 1 |
| Bonhaus, DW; Hosford, DA; McNamara, JO | 1 |
| Dichter, M; Morad, M; Tang, CM | 1 |
| Jacocks, HM; McMahon, PN; Werling, LL | 1 |
| Rabe, CS; Tabakoff, B | 1 |
| Bennett, MV; McGurk, JF; Zukin, RS | 1 |
| Gündel, J; Matthies, H; Steinhäuser, C | 1 |
| Dildy-Mayfield, JE; Leslie, SW | 1 |
| Ascher, P; Henderson, G; Johnson, JW | 1 |
| Haesslein, JL; Hunt, PF; Jouanen, A; Massardier, D; Tremblet, AM | 1 |
| Colpaert, FC; Koek, W | 2 |
| Legendre, P; Westbrook, GL | 1 |
| Kline, PA; Nowak, LM; Wright, JM | 1 |
| Ogita, K; Yoneda, Y | 2 |
| Larson, AA; Sun, XF | 1 |
| Brody, MJ; Rutherford, DS; Varner, KJ; Vasquez, EC | 1 |
| Linn, DM; Massey, SC | 1 |
| Huettner, JE | 3 |
| Cheramy, A; Desce, JM; Gauchy, C; Glowinski, J; Godeheu, G; Kemel, ML; Krebs, MO | 1 |
| Boksa, P; Chaudieu, I; Mount, H; Quirion, R | 1 |
| Blanton, MG; Kriegstein, AR; LoTurco, JJ | 1 |
| Colling, JM; Robertson, SC; Talman, WT | 1 |
| Craig, CG; White, TD | 1 |
| Aizenman, E; Reynolds, IJ; Tang, LH | 1 |
| Alasti, N; Artman, LD; Nemeth, EF; Parks, TN | 1 |
| Cai, NS; Erdö, SL; Kiss, B | 1 |
| Bednar, DL; Karbon, EW; Maciver, CR | 1 |
| Vamvakidès, A | 1 |
| Brown, L; Gonzales, RA; Woodward, JJ | 1 |
| Insel, TR; Skolnick, P; Trullas, R; Winslow, JT | 1 |
| Compton, RP; Hood, WF; Monahan, JB | 1 |
| Grudt, TJ; Jahr, CE | 1 |
| Carter, CJ; Lloyd, KG; Scatton, B; Zivkovic, B | 1 |
| Dalkara, T; Erdemli, G; Onur, R | 1 |
| Benveniste, M; Mayer, ML; Mienville, JM; Sernagor, E | 1 |
| Okamoto, K; Sakai, Y; Sekiguchi, M | 1 |
| Nistri, A; Sivilotti, L; Welsh, DM | 1 |
| Baimbridge, KG; Kessler, M; Lynch, G; Oliver, MW; Shacklock, JA | 1 |
| Britt, M; Chapdelaine, MJ; Keith, RA; LaMonte, D; Mangano, TJ; Patel, J; Powel, RJ; Pullan, LM; Stumpo, RJ; Warwick, PJ | 1 |
| DiFiglia, M; Freese, A; Koroshetz, WJ | 1 |
| Kendall, DA; Robinson, JP | 1 |
| Johnston, MV; McDonald, JW | 1 |
| Dingledine, R; McNamara, D | 1 |
| Sansom, MS; Usherwood, PN | 1 |
| Cordi, AA; Monahan, JB; Reisse, J | 1 |
| Nag, S; Riopelle, RJ | 1 |
| Cler, JA; Emmett, MR; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 1 |
| Thomson, AM | 1 |
| Dow, KE; Riopelle, RJ | 1 |
| Stone, TW | 1 |
| Cha, JH; Penney, JB; Sakurai, SY; Young, AB | 1 |
| Bian, XP; Martin, D; Morrisett, RA; Swartzwelder, HS; Wilson, WA | 1 |
| Pittaluga, A; Raiteri, M | 1 |
| Albuquerque, EX; Alkondon, M | 1 |
| Keith, R; Patel, J; Salama, A; Thompson, C; Zinkand, WC | 1 |
| Baron, BM; Harrison, BL; McDonald, IA; Nyce, PL; Salituro, FG; Stewart, KT | 1 |
| Akaike, N; Murase, K; Nakagawa, T; Randic, M; Shirasaki, T | 1 |
| Aizenman, E; Hartnett, KA; Reynolds, IJ | 1 |
| Aizenman, E; Reynolds, IJ; Rush, EA | 1 |
| Calligaro, DO; Dingledine, R; McNamara, D; McQuaid, LA; O'Malley, PJ; Smith, EC | 1 |
| Clark, GD; Clifford, DB; Zorumski, CF | 1 |
| Ben-Ari, Y; Cherubini, E; Corradetti, R; Gaiarsa, JL | 1 |
| Donald, AE; Foster, AC; Hutson, PH; Iversen, LL; Iversen, SD; Kemp, JA; Leeson, PD; Marshall, GR; Oles, RJ; Singh, L | 1 |
| Ikin, AF; Kloog, Y; Sokolovsky, M | 1 |
| Ascher, P; Henderson, G; Johnson, JW; Sather, W | 1 |
| Gonzales, RA; Woodward, JJ | 2 |
| Biesterfeldt, JP; Compton, RP; Cordi, AA; Hood, WF; Lanthorn, TH; Monahan, JB; Vazquez, MI; Wood, PL | 1 |
| Courtney, MJ; Lambert, JJ; Nicholls, DG | 1 |
| Mayer, ML; Patneau, DK | 1 |
| Akaike, N; Fukuda, A; Nakagawa, T; Shirasaki, T; Wakamori, M | 1 |
| Baron, BM; Harrison, BL; McDonald, IA; Miller, FP; Palfreyman, MG; Salituro, FG; Schmidt, CJ; Sorensen, SM; White, HS | 1 |
| Cruz, LJ; Gullak, MF; Mena, EE; Olivera, BM; Pagnozzi, MJ; Richter, KE; Rivier, J | 1 |
| Ogita, K; Suzuki, T; Yoneda, Y | 2 |
| Godfraind, JM | 1 |
| Iino, M; Ozawa, S; Tsuzuki, K | 1 |
| Bertolino, M; Costa, E; Mazzetta, J; Vicini, S | 1 |
| Johnson, KM; Morter, RS; Snell, LD | 2 |
| Bonhaus, DW; McNamara, JO; Skaryak, L; Yeh, GC | 1 |
| Murase, K; Randic, M; Ryu, PD | 1 |
| Ceserani, R; Gaviraghi, G; Maraia, G; Reggiani, A | 1 |
| Brooker, G; Costa, E; Danysz, W; Wroblewski, JT | 1 |
| Alho, H; Barbaccia, ML; Costa, E; Szekely, AM | 1 |
| Deschenes, NL; Ransom, RW | 2 |
| Salt, TE | 1 |
| Hoffman, PL; Moses, F; Rabe, CS; Tabakoff, B | 1 |
| Costa, E; Fadda, E; Lazarewicz, JW; Mazzetta, J; Wroblewski, JT | 1 |
| Dingledine, R; Kleckner, NW | 1 |
| Dingledine, R; Kleckner, NW; McBain, CJ; Wyrick, S | 1 |
| Miller, RJ; Reynolds, IJ | 1 |
| Bonhaus, DW; McNamara, JO | 2 |
| Bauce, L; Kemp, DE; Weiss, S | 1 |
| Drejer, J; Honoré, T; Jensen, LH; Sheardown, MJ; Stidsen, CE | 1 |
| Dudek, S; Joly, M; Lynch, G; Muller, D; Schottler, F; Thibault, O | 1 |
| Araneda, R; Bustos, G | 1 |
| Daly, MP; Demediuk, P; Faden, AI | 1 |
| Jahr, CE; Lester, RA; Parker, JD; Quarum, ML; Weber, E | 1 |
| Harris, KM; Miller, RJ | 1 |
| Canonico, PL; Nicoletti, F | 1 |
| Dun, NJ; Minota, S; Miyazaki, T; Read, HL; Wang, MY | 1 |
| Astier, H; Tapia-Arancibia, L | 1 |
| Aizenman, E; Rosenberg, PA | 1 |
| Johnson, KM; Jones, SM | 1 |
| Busija, DW; Leffler, CW | 1 |
| Keith, RA; Klika, AB; Mangano, TJ; Meiners, BA; Patel, J; Salama, AI; Stumpo, RJ | 1 |
| Cooper, SM; Cotman, CW; Geddes, JW; Meldrum, BS; Patel, S | 1 |
| Drejer, J; Honoré, T; Nielsen, EO; Sheardown, M | 1 |
| de Carvalho, LP; Geoffroy, M; Lambolez, B; Rossier, J; Stinnakre, J | 1 |
| Desban, M; Gauchy, C; Glowinski, J; Kemel, ML; Krebs, MO | 1 |
| Johnston, MV; McDonald, JW; Silverstein, FS; Uckele, JE | 1 |
| Bennett, MV; Kushner, L; Lerma, J; Zukin, RS | 1 |
| Foster, AC; Iversen, LL; Kemp, JA; Leeson, PD; Priestley, T; Tridgett, R; Woodruff, GN | 1 |
| Johnson, KM; Snell, LD | 1 |
| Birch, PJ; Grossman, CJ; Hayes, AG | 2 |
| Costa, E; Danysz, W; Fadda, E; Wroblewski, JT | 1 |
| Homma, S | 1 |
| Fletcher, EJ; Lodge, D | 1 |
| Mayer, ML; Vyklický, L; Westbrook, GL | 1 |
| Beitz, AJ; Larson, AA | 1 |
| Cotman, CW; Monaghan, DT; Nguyen, L; Olverman, HJ; Watkins, JC | 1 |
| Davidson, N; Fong, TM; Lester, HA | 1 |
| Johnson, KM; Sacaan, AI; Snell, LD | 1 |
| Jackson, EA; Kelly, PH | 1 |
| Biella, G; Sotgiu, ML | 1 |
| Buller, AL; Larson, HC; Monaghan, DT; Morrisett, RA | 1 |
| Kelly, KM; Macdonald, RL; Rock, DM | 1 |
| Hoffman, PL; Iorio, KR; Snell, LD; Tabakoff, B | 1 |
| Carter, AJ | 1 |
| Akaike, N; Kimura, S; Nishikawa, M | 1 |
| Boel, E; Suzdak, PD; Thomsen, C | 1 |
| Battaglia, G; Bruno, V; Copani, A; Nicoletti, F; Raffaele, R; Shinozaki, H | 1 |
| Bruno, VM; Choi, DW; Dugan, LL; Giffard, RG; Goldberg, MP | 1 |
| Ebert, B; Frydenvang, K; Johansen, TN; Krogsgaard-Larsen, P; Madsen, U | 1 |
| Belknap, JK; Carter, LA; Crabbe, JC; Janowsky, A | 1 |
| Aguglia, U; Bertorelli, R; De Sarro, A; De Sarro, G; Ongini, E | 1 |
| García, Y; Ibarra, C; Jaffé, EH | 1 |
| Hofmann, HD; Huba, R; Yamashita, M | 1 |
| Pidoplichko, VI; Reymann, KG | 1 |
| Oja, SS; Saransaari, P | 2 |
| Bloms-Funke, P; Madeja, M; Musshoff, U; Speckmann, EJ | 1 |
| Breese, GR; Criswell, HE; Duncan, GE; Keir, WJ; McCown, TJ; Morrow, AL; Simson, PE | 1 |
| Hayashi, T; Kagaya, A; Motohashi, N; Shimizu, M; Takebayashi, M; Uchitomi, Y; Yamawaki, S | 1 |
| MacDonald, JF; Wang, LY | 1 |
| Korpi, ER; Wegelius, K | 1 |
| Ascher, P; Neyton, J; Paoletti, P | 1 |
| Turecek, R; Vlachová, V; Vyklický, L | 1 |
| Nolan, JP; Panizzon, KL; Wallis, RA | 1 |
| Deben, SE; Gonzalez-Alvear, GM; Thompson-Montgomery, D; Werling, LL | 1 |
| Bockaert, J; Fagni, L; Lafon-Cazal, M; Olivier, M | 1 |
| Coco, S; Fumagalli, G; Matteoli, M; Verderio, C | 1 |
| Azzazy, HM; Gross, GW; Rhoades, BK; Wu, MC | 1 |
| McQuade, RD; Taylor, LA; Tice, MA | 1 |
| Anantharam, V; Rodríguez-Paz, JM; Treistman, SN | 1 |
| Büsselberg, D; Michael, D; Platt, B | 1 |
| Harris, EW; MacPherson, P; McBurney, MW; Morley, P; Whitfield, JF | 1 |
| al-Baracanji, KA; Bailey, SJ; Barone, FC; Benham, CD; Feuerstein, G; Harries, MH; Harrison, DC; Hunter, AJ; Lysko, PG; Price, WJ | 1 |
| Legendre, P; Rosenmund, C; Westbrook, GL | 1 |
| Andou, Y; Enomoto, R; Kataoka, K; Mitani, A; Ogita, K; Yoneda, Y | 1 |
| Birse, EF; Eaton, SA; Jane, DE; Jones, PL; Pook, PC; Porter, RH; Roberts, PJ; Sunter, DC; Udvarhelyi, PM; Wharton, B | 1 |
| Hardy, M; Lee, VM; Pleasure, D; Pleasure, SJ; Reddy, UR; Shi, QY; Tang, CM; Younkin, DP | 1 |
| Calligaro, DO; Monn, JA; O'Malley, PJ | 1 |
| Block, F; Schwarz, M; Sontag, KH | 1 |
| Bowlby, MR | 1 |
| Ferrer-Montiel, AV; Montal, M; Planells-Cases, R; Sun, W | 1 |
| Boos, R; Schneider, H; Wässle, H | 1 |
| Akaike, N; Harata, N; Uneyama, H | 1 |
| Jane, DE; Jones, PL; Pook, PC; Salt, TE; Sunter, DC; Watkins, JC | 1 |
| Kadlec, O; Schuurkes, J; Seferna, I | 1 |
| Johnson, KM; Jones, SM; Sacaan, AI; Snell, LD | 1 |
| Fahey, JM; Lindquist, DG; Miller, LG; Pritchard, GA | 1 |
| Harmsworth, WL; Sofia, RD; White, HS; Wolf, HH | 1 |
| Churn, SB; DeLorenzo, RJ; Limbrick, D; Sombati, S | 1 |
| Arima, T; Kitamura, Y; Nakamura, J; Nomura, Y; Sato, T | 1 |
| Finger, W; Föhr, KJ; Schirm, T | 1 |
| Dobos, M; Kálmánchey, R; Krause, I; Liptai, Z; Majtényi, K; Nagy, I; Szücs, L | 1 |
| Opitz, T; Pidoplichko, VI; Reymann, KG; Shinozaki, H; Wilsch, VW | 1 |
| Kemp, JA; Ochu, E; Priestley, T | 1 |
| Lock, EA; Trainor, A; Widdowson, PS | 1 |
| Fahey, JM; Miller, LG | 1 |
| Flores, A; Soto, E; Vega, R | 1 |
| Brown, LM; Gonzales, RA | 1 |
| Rajdev, S; Reynolds, IJ | 2 |
| Aronstam, RS; Dennison, RL; Martin, DC | 1 |
| Becquet, D; Deprez, P; Fache, MP; Faudon, M; Giraud, P; Héry, F; Héry, M | 1 |
| Chetkovich, DM; Sweatt, JD | 1 |
| Williams, K | 1 |
| Butcher, SP; Cottrell, DA; Hodgkiss, JP; Kelly, JS; Kuno, A; Ohkubo, M; Olverman, HJ; Sherriffs, HJ; Shirakawa, K | 1 |
| Woodward, JJ | 1 |
| Eróstegui, C; Flores, A; Soto, E; Vega, R | 1 |
| Bonanno, G; Donadini, F; Fedele, E; Fontana, G; Raiteri, M; Vallebuona, F | 1 |
| Challis, RA; Gray, DW; Mistry, R; Nahorski, SR | 1 |
| Chen, DZ; Chen, SH; Katsura, M; Kuriyama, K; Ohkuma, S | 1 |
| Kovács, KJ; Larson, AA | 1 |
| Han, D; Ogita, K; Yoneda, Y | 1 |
| Hargreaves, RJ; Hill, RG; Iversen, LL | 1 |
| Janáky, R; Oja, SS; Saransaari, P; Varga, V | 1 |
| Lee, YH; Leslie, SW; Randall, PK; Spuhler-Phillips, K | 1 |
| Akerman, KE; Courtney, M; Hallnemo, G; Westlind-Danielsson, A; Wilkinson, A | 1 |
| Akaike, N; Ishibashi, H; Shirasaki, T; Takahashi, Y; Yamanaka, H | 1 |
| Carter, C; Fage, D; Voltz, C | 1 |
| Gu, Y; Huang, LY | 1 |
| Barnett, A; Coffin, V; Cohen-Williams, M | 1 |
| Kamiya, H; Sawada, S; Yamamoto, C | 1 |
| Györi, J; Moroz, LL; Salánki, J | 1 |
| Komuro, H; Rakic, P | 1 |
| Lux, HD; Parsons, CG; Zong, X | 1 |
| Brocard, JB; Rajdev, S; Reynolds, IJ | 1 |
| Gruner, R; Lodge, D; Millar, J; Parsons, CG; Rozental, J | 1 |
| Lunn, WH; McDonald, JW; Salhoff, CR; Schoepp, DD | 1 |
| Bennett, MV; Durand, GM; Zhang, L; Zheng, X; Zukin, RS | 1 |
| Brautigan, DL; MacDonald, JF; Orser, BA; Wang, LY | 1 |
| Blanck, TJ; Fiskum, G; Fox, LG; Hoehner, PJ; Hurt, KJ; Rosenthal, RE; Werling, LL | 1 |
| McLean, MJ; Wamil, AW | 1 |
| Breese, GR; Criswell, HE; Duncan, GE; Herbert, JS; McCown, TJ; Morrow, AL; Simson, PE | 1 |
| Benveniste, M; Mayer, ML | 1 |
| Biella, G; Lacerenza, M; Marchettini, P; Sotgiu, ML | 1 |
| Haas, HL; Sharonova, IN; Vorobjev, VS; Walsh, IB | 1 |
| Cortinovis, S; Lucca, A; Lucini, V | 1 |
| Barbin, G; Ben-Ari, Y; Kwiecien, R; Medina, I | 1 |
| Biton, C; Lepagnol, JM; Randle, JC | 1 |
| Coyle, JT; Handen, JS; Montgomery, DT; Puttfarcken, PS; Werling, LL | 1 |
| Yaksh, TL; Yamamoto, T | 1 |
| Eaton, SA; Jane, DE; Jones, PL; Pook, PC; Porter, RH; Roberts, PJ; Salt, TE; Sunter, DC; Udvarhelyi, PM; Watkins, JC | 1 |
| Becker, CM; Gass, P; Kiessling, M; Muelhardt, C; Sommer, C | 1 |
| Chandler, LJ; Crews, FT; Sumners, C | 1 |
| Bashir, ZI; Berretta, N; Bortolotto, ZA; Collingridge, GL; Davies, CH; Henley, JM; Irving, AJ; Jane, DE; Seal, AJ; Watkins, JC | 1 |
| Skeen, GA; Twyman, RE; White, HS | 1 |
| Ishida, M; Ohfune, Y; Saitoh, T; Shimamoto, K; Shinozaki, H | 1 |
| Masu, M; Nakanishi, S; Sakurada, K | 1 |
| Aizenman, E; Hartnett, KA; Reynolds, IJ; Rothermund, KD; Tidwell, R; Zeleski, DM | 1 |
| Fedele, E; Pittaluga, A; Raiteri, M; Risiglione, C | 1 |
| Balázs, R; Benke, D; Hidaka, H; Möhler, H; Resink, A; Villa, M | 1 |
| Buisson, A; Choi, DW | 1 |
| Chuang, DM; Gao, XM; Hough, CJ; Irwin, RP; Rogawski, MA | 1 |
| Giovannucci, DR; Stuenkel, EL | 1 |
| Ohno, M; Watanabe, S | 1 |
| Chen, X; Hurlbert, M; Joseph, DB; Kumar, KN; Michaelis, EK; Michaelis, ML | 1 |
| Berrino, L; D'Amico, M; de Novellis, V; Pizzirusso, A; Rossi, F | 1 |
| Bruno, V; Marinozzi, M; Nicoletti, F; Pellicciari, R; Thomsen, C | 1 |
| Buisson, A; Choi, DW; Yu, SP | 1 |
| Pattarini, R; Pittaluga, A; Raiteri, M; Severi, P | 1 |
| Leslie, SW; Randoll, LA; Spuhler-Phillips, K; Weaver, MS; Wilson, WR | 1 |
| Bockaert, J; Manahan-Vaughan, D; Pin, JP; Reiser, M; Reymann, KG; Riedel, G; Wilsch, V | 1 |
| Kaneko, A; Sasaki, T | 1 |
| Bochet, P; de Carvalho, LP; Rossier, J | 1 |
| Consolandi, O; Memo, M; Pizzi, M; Spano, PF | 1 |
| Andjus, PR; Cherubini, E; Khiroug, L; Nistri, A; Yakel, JL | 1 |
| Akerman, KE; Holopainen, I; Janáky, R; Oja, SS; Varga, V | 1 |
| Gribkoff, VK; Molinoff, PB; Zhong, J | 1 |
| Badia, A; Clos, MV; Garcia Sanz, A; Trullas, R | 1 |
| Madamba, SG; Schweitzer, P; Siggins, GR; Zieglgänsberger, W | 1 |
| Hayaishi, O; Ito, S; Minami, T; Mori, H; Okuda-Ashitaka, E | 1 |
| Gunasekar, PG; Kanthasamy, AG; Matsumoto, RR; Trunong, DD | 1 |
| Canzoniero, LM; Choi, DW; Finley, MF; Huettner, JE; Sensi, SL; Turetsky, DM | 1 |
| Blank, T; Nijholt, I; Spiess, J; Zwart, R | 1 |
| Basile, AS; Fossom, LH; Skolnick, P | 1 |
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| Kegel, FS; Rietman, BM; Verliefde, AR | 1 |
| Andreetta, F; Bettini, E; Buson, A; Capelli, AM; Cardullo, F; Carignani, C; Griffante, C; Guiral, L; Negri, M; Sava, A; Senar-Sancho, SA | 1 |
| Jeong, HJ; Vandenberg, RJ; Vaughan, CW | 1 |
| Kiedrowski, L | 1 |
| Kodama, D; Ono, H; Tanabe, M | 1 |
| Cunha, RA; Musante, V; Pittaluga, A; Raiteri, M; Summa, M | 1 |
| Beleboni, RO; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Fachim, HA; Gobbo-Neto, L; Lopes, NP; Pereira, AC | 1 |
| Cao, H; Ren, WH; Zhang, YQ; Zhao, ZQ; Zhu, MY | 1 |
| Gao, W; Johnson, JW; Siegler Retchless, B | 1 |
| Cameron, A; Gong, Z; Harrington, J; Lockridge, A; Newland, B; Romero, G; Yuan, LL | 1 |
| Harris, J; McClymont, DW; Mellor, IR | 1 |
| Chiarugi, A; Formentini, L; Gerace, E; Landucci, E; Moroni, F; Pellegrini-Giampietro, DE; Scartabelli, T | 1 |
| Kalinina, NI; Kurchavyĭ, GG; Veselkin, NP | 1 |
| Jiang, ZL; Ke, KF; Li, X; Peng, LL; Wang, GH; Zhang, YF | 1 |
| Battaglia, G; Bruno, V; Merlo, S; Molinaro, G; Nicoletti, F; Sortino, MA; Spampinato, SF | 1 |
| Clarke, RJ; Glasgow, NG; Johnson, JW | 1 |
| McGinley, MJ; Tovar, KR; Westbrook, GL | 1 |
| Rozsa, E; Vigh, J | 1 |
| Bonanno, G; Candiani, S; Faimali, M; Ferrando, S; Gallus, L; Milanese, M; Pittaluga, AM; Ramoino, P; Usai, C | 1 |
| An, Y; Belevych, N; Chen, Q; Herschman, H; Quan, N; Wang, Y; Zhang, H | 1 |
| Dudka, J; Oniszczuk, T; Poleszak, E; Serefko, A; Szopa, A; Wlaź, P; Wośko, S; Wróbel, A | 1 |
| Chang, JP; Lane, HY; Tsai, GE | 1 |
| Chen, T; Dai, SH; Fei, Z; Jiang, XF; Luo, P; Qin, N; Rao, W; Yang, YF; Zhang, L | 1 |
| Chen, LL; Ji, F; Lu, W; Tian, T; Wang, N; Zhang, XY | 1 |
| da Costa, FL; de Oliveira, AC; Gomez, MV; Gomez, RS; Lima, IV; Mendes-Goulart, VA; Pinto, MC; Resende, RR; Romano-Silva, MA; Rosa, DV | 1 |
| Balsara, RD; Castellino, FJ; Cheriyan, J; Mezes, C; Zhou, N | 1 |
| Balu, DT; Coyle, JT; Ishiwata, S; Nishikawa, T; Umino, A | 1 |
| Bogdanova, A; Gassmann, M; Goede, JS; Hänggi, P; Kemp, PJ; Schmugge, M; Speer, O; Telezhkin, V | 1 |
| Granzotto, A; Sensi, SL | 1 |
| Hanig, JP; Liu, F; Patterson, TA; Paule, MG; Rainosek, SW; Sadovova, N; Slikker, W; Wang, C | 1 |
| Ali, MK; Ding, XS; Duclot, F; Fang, XQ; Feng, S; Groveman, BR; Jiang, XH; Kabbaj, M; Lin, SX; Pflueger, M; Qiao, H; Salter, MW; Santiago-Sim, T; Wang, W; Xin, WK; Xu, J; Yu, XM | 1 |
| Güntert, T; Hänggi, P; Hornemann, T; Ogunshola, OO; Othman, A; Sonda, S; Suriyanarayanan, S; Zuellig, RA | 1 |
| Biggi, S; Borsello, T; Buccarello, L; Di Marino, D; Lippiello, P; Miniaci, MC; Rumio, C; Sclip, A; Tonna, N | 1 |
| Corsini, S; Ghezzi, F; Monni, L; Nistri, A | 1 |
| Bahi-Buisson, N; Banne, E; Brueton, LA; Chen, W; Chung, SK; Cushion, TD; Dobyns, WB; Fawcett, KA; Fry, AE; Giuliano, F; Helbig, KL; Hu, C; Iago, HF; Kannan, V; Kerr, MP; Knight, KM; Kofman, LH; Kusumoto, H; Layet, V; Lemke, JR; Lerman-Sagie, T; Mackenzie, AB; Mefford, HC; Meiner, V; Mirzaa, GM; Mugalaasi, H; Muir, AM; Mullins, JGL; Patel, CV; Pilz, DT; Rees, MI; Shaulsky, GH; Shemer-Meiri, L; Sims, D; Stoodley, N; Swanger, SA; Thompson, BAN; Traynelis, SF; Yuan, H; Zelnik, N; Zhang, J | 1 |
| Hu, L; Liu, M; Pan, S; Pei, L; Shang, Y; Song, L; Wu, Y; Xian, W; Xiong, W; Yao, S | 1 |
| Canonico, PL; Genazzani, AA; Lim, D; Mapelli, L; Moccia, F | 1 |
| Antonietti, A; Dehghani, F; Ghadban, C; Grabiec, U; Groth, T; Hohmann, T; Mackie, K; Rothgänger, C; Wong, D | 1 |
| Bading, H; Bas-Orth, C; Buchthal, B; Koch, M; Lau, D | 1 |
| Berlinguer Palmini, R; Di Luca, M; Gardoni, F; Gerace, E; Iezzi, D; Landucci, E; Mannaioni, G; Moroni, F; Pellegrini-Giampietro, DE; Scartabelli, T; Zianni, E | 1 |
| Kozyrev, SA; Nikitin, VP; Solntseva, SV | 1 |
| Chen, K; Fang, H; Gao, S; Hu, S; Sun, X; Wang, H | 1 |
| Flores-Hernandez, J; Islas, ÁA; Lopez-Lopez, G; Salinas-Stefanon, EM; Scior, T; Torres-Ramirez, O | 1 |
| Bittner, S; Bock, S; Budde, T; Cerina, M; Epping, L; Fernandez-Orth, J; Gola, L; Henes, A; Herrmann, AM; Kovac, S; Meuth, SG; Nelke, C; Neuhaus, W; Platten, M; Räuber, S; Ritter, N; Ruck, T; Schroeter, CB; Seebohm, G; Wasser, B | 1 |
| Cebada, J; Flores, A; Manjarrez, E; Monjaraz, E; Moyaho, A; Ramírez, A | 1 |
| Leng, T; Maysami, S; Meller, R; Pearson, A; Simon, R; Xie, M; Xiong, ZG | 1 |
| Amin, JB; He, M; Leng, X; Prasad, R; Wollmuth, LP; Zhou, HX | 1 |
| Goda, Y; Letellier, M | 1 |
| Deng, T; Hu, Z; Liu, H; Pan, X; Wang, E; Yang, L; Yang, X; Zhou, L | 1 |
13 review(s) available for n-methylaspartate and glycine
| Article | Year |
|---|---|
Ligands for glutamate receptors: design and therapeutic prospects.
Topics: Animals; Drug Design; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Ligands; N-Methylaspartate; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Synapses | 2000 |
Evidence for hybrid NMDA/kainate receptors from protein reconstitution studies and expression of vertebrate CNS RNAs in Xenopus oocytes.
Topics: Animals; Chromatography, Affinity; Glycine; Ion Channel Gating; Kainic Acid; N-Methylaspartate; Oocytes; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Xenopus laevis | 1992 |
Effects of quinolinic and kynurenic acids on central neurons.
Topics: Action Potentials; Animals; Brain; Convulsants; gamma-Aminobutyric Acid; Glycine; Kynurenic Acid; Models, Neurological; N-Methylaspartate; Neurons; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission | 1991 |
Competitive antagonism of glycine at the N-methyl-D-aspartate (NMDA) receptor.
Topics: Animals; Binding, Competitive; Glycine; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Up-Regulation | 1991 |
[Action mechanism of adamantamines: do their activity on glutamatergic receptors intervene in the expression of their pharmacological profile?].
Topics: Amantadine; Antibodies; Antiparkinson Agents; gamma-Aminobutyric Acid; Glycine; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate | 1991 |
Single-channel studies of glutamate receptors.
Topics: Animals; Anions; Astacoidea; Cations, Divalent; Electrophysiology; Glutamates; Glutamic Acid; Glycine; Grasshoppers; Hippocampus; Ibotenic Acid; Invertebrates; Ion Channel Gating; Kainic Acid; Membrane Potentials; Models, Biological; N-Methylaspartate; Neuromuscular Junction; Neurotransmitter Agents; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship; Synaptic Transmission; Vertebrates | 1990 |
Antagonists of NMDA-activated current in cortical neurons: competition with glycine and blockade of open channels.
Topics: Animals; Cerebral Cortex; Dizocilpine Maleate; Electrochemistry; Glycine; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate | 1990 |
TCP binding: a tool for studying NMDA receptor-mediated neurotransmission in kindling.
Topics: Animals; Aspartic Acid; Brain; Glycine; Kindling, Neurologic; N-Methylaspartate; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
The neuroanatomical specificity of ethanol action on ligand-gated ion channels: a hypothesis.
Topics: Animals; Brain; Ethanol; gamma-Aminobutyric Acid; Glycine; Humans; Ion Channels; Ligands; Models, Neurological; Muscimol; N-Methylaspartate; Nicotine; Receptors, GABA-A | 1993 |
Pharmacologic regulation of the NMDA receptor-ionophore complex.
Topics: Animals; Binding Sites; Biogenic Polyamines; Glycine; Humans; Ion Channels; Ionophores; N-Methylaspartate; Phencyclidine; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1993 |
Neuroprotective NMDA antagonists: the controversy over their potential for adverse effects on cortical neuronal morphology.
Topics: Animals; Cell Survival; Cerebral Cortex; Dextrorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Energy Metabolism; Excitatory Amino Acid Antagonists; Glycine; Gyrus Cinguli; Ketamine; N-Methylaspartate; Neurons; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Vacuoles | 1994 |
Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain.
Topics: Analgesics; Animals; Anticonvulsants; Clinical Trials as Topic; Diabetic Neuropathies; Glycine; Humans; Indans; Monoamine Oxidase Inhibitors; N-Methylaspartate; Pain | 2007 |
Attention deficit hyperactivity disorder and N-methyl-D-aspartate (NMDA) dysregulation.
Topics: Adolescent; Adult; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Drug Design; Glutamic Acid; Glycine; Humans; Impulsive Behavior; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate | 2014 |
2 trial(s) available for n-methylaspartate and glycine
| Article | Year |
|---|---|
Glycine prodrug facilitates memory retrieval in humans.
Topics: Acetamides; Adult; Female; Glycine; Humans; Learning; Male; Memory; N-Methylaspartate; Placebos; Prodrugs; Synaptic Transmission | 1991 |
Safety, pharmacokinetics, and pharmacodynamics of CHF 3381, a novel N-methyl-D-aspartate antagonist, after single oral doses in healthy subjects.
Topics: Administration, Oral; Adult; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography; Food; Glycine; Half-Life; Humans; Indans; Male; Memory; Metabolic Clearance Rate; N-Methylaspartate | 2003 |
623 other study(ies) available for n-methylaspartate and glycine
| Article | Year |
|---|---|
A minimal model to account for the response of N-Methyl-D-aspartate receptors expressed in Xenopus oocyte injected with rat brain mRNA.
Topics: Animals; Binding Sites; Brain; Female; Glycine; Kinetics; Male; Mathematics; Membrane Potentials; Models, Neurological; N-Methylaspartate; Oocytes; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Xenopus | 1992 |
Selective potentiation of N-methyl-D-aspartate-induced current by protein kinase C in Xenopus oocytes injected with rat brain RNA.
Topics: Animals; Brain; Enzyme Activation; Glutamates; Glycine; Male; Membrane Potentials; N-Methylaspartate; Ovum; Protein Kinase C; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Tetradecanoylphorbol Acetate; Xenopus | 1992 |
Autoradiography and interaction of modulators of NMDA receptor activation.
Topics: Amino Acids; Animals; Anticonvulsants; Autoradiography; Binding, Competitive; Brain; Brain Mapping; Convulsants; Culture Techniques; Dizocilpine Maleate; Epilepsy; Glycine; N-Methylaspartate; Neurons; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Membranes; Synaptic Transmission | 1992 |
Effects of ovarian steroids on the gonadotropin response to N-methyl-D-aspartate and on hypothalamic excitatory amino acid levels during sexual maturation in female rats.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Estrogens; Female; Follicle Stimulating Hormone; Glutamates; Glutamic Acid; Glycine; Gonadotropin-Releasing Hormone; Gonadotropins; Hypothalamus; Luteinizing Hormone; N-Methylaspartate; Ovary; Preoptic Area; Progesterone; Rats; Rats, Inbred Strains; Sexual Maturation | 1992 |
L-proline activates glutamate and glycine receptors in cultured rat dorsal horn neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cells, Cultured; Female; Glutamates; Glycine; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Pregnancy; Proline; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Glycine; Receptors, Neurotransmitter; Spinal Cord; Strychnine | 1992 |
NMDA, non-NMDA and glycine receptors mediate binaural interaction in the lateral superior olive: physiological evidence from mouse brain slice.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Electric Stimulation; Functional Laterality; Glycine; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Olivary Nucleus; Quinoxalines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1992 |
Heteromeric NMDA receptors: molecular and functional distinction of subtypes.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Cell Line; Cloning, Molecular; DNA; Glutamates; Glutamic Acid; Glycine; Macromolecular Substances; Magnesium; Membrane Potentials; Molecular Sequence Data; Multigene Family; N-Methylaspartate; Oligonucleotide Probes; Organ Specificity; Peptides; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA, Messenger; Sequence Homology, Nucleic Acid; Transfection | 1992 |
Serotonin1A facilitation of frog motoneuron responses to afferent stimuli and to N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; 8-Hydroxy-2-(di-n-propylamino)tetralin; Afferent Pathways; Animals; Electric Stimulation; Evoked Potentials; Glycine; In Vitro Techniques; Kainic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Nerve Fibers; Quisqualic Acid; Rana pipiens; Serotonin; Spinal Cord; Spinal Nerve Roots; Tetrahydronaphthalenes; Tetrodotoxin; Tropanes | 1992 |
Competitive antagonism of glutamate receptor channels by substituted benzazepines in cultured cortical neurons.
Topics: Animals; Benzazepines; Binding Sites; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1992 |
Characterization of 3-carboxy-5-phosphono-1,2,3,4-tetrahydroisoquinoline (SC-48981), a potent competitive N-methy-D-aspartate (NMDA) receptor antagonist, in vitro and in vivo.
Topics: Animals; Binding, Competitive; Cerebellum; Cyclic GMP; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Isoquinolines; Male; Mice; N-Methylaspartate; Organophosphorus Compounds; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Tetrahydroisoquinolines | 1992 |
Glycine response in isolated dorsal cochlear nucleus of C57BL/6J mouse.
Topics: Animals; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Pons; Receptors, Glycine; Receptors, Neurotransmitter; Strychnine | 1992 |
Differential effects of neuroexcitatory amino acids on corticotropin-releasing hormone-41 and vasopressin release from rat hypothalamic explants.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arginine Vasopressin; Corticotropin-Releasing Hormone; Glycine; Hypothalamus; Kainic Acid; Magnesium; Male; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar | 1992 |
NMDA receptors assessed by autoradiography with [3H]L-689,560 are present but not enriched on corticofugal-projecting pyramidal neurones.
Topics: Aminoquinolines; Animals; Autoradiography; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Male; N-Methylaspartate; Neural Pathways; Neurons, Efferent; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Strychnine; Tritium | 1992 |
DL-tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy.
Topics: Animals; Cell Membrane; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Hippocampus; Molecular Structure; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tetrazoles | 1992 |
Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation.
Topics: Animals; Cells, Cultured; Chloride Channels; Furosemide; Glycine; Ion Channels; Membrane Proteins; N-Methylaspartate; Neurons; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1992 |
Quinoxaline derivatives: structure-activity relationships and physiological implications of inhibition of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor-mediated currents and synaptic potentials.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebral Cortex; Electrophysiology; Evoked Potentials; Female; Glycine; Hippocampus; Ibotenic Acid; Kainic Acid; Male; Membrane Potentials; N-Methylaspartate; Oocytes; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Structure-Activity Relationship; Synapses; Xenopus | 1992 |
Arcaine blocks N-methyl-D-aspartate receptor responses by an open channel mechanism: whole-cell and single-channel recording studies in cultured hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biguanides; Cations, Divalent; Cells, Cultured; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glycine; Hippocampus; Ibotenic Acid; Ion Channels; Kainic Acid; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Ethanol inhibition of N-methyl-D-aspartate-activated ion current in rat hippocampal neurons is not competitive with glycine.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Fetus; Glycine; Hippocampus; Ion Channels; Kinetics; N-Methylaspartate; Neurons; Rats | 1992 |
NMDA treatment and K(+)-induced depolarization selectively promote the expression of an NMDA-preferring class of the ionotropic glutamate receptors in cerebellar granule neurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cell Survival; Cells, Cultured; Cerebellar Cortex; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Potassium; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Up-Regulation | 1992 |
Binding properties of 3-[125I]iodophencyclidine, a new radioligand for N-methyl-D-aspartate-gated ionic channels.
Topics: Animals; Cell Membrane; Glutamates; Glycine; Iodine Radioisotopes; Ion Channel Gating; Ion Channels; N-Methylaspartate; Neurons; Radioligand Assay; Rats; Rats, Inbred Strains | 1992 |
Specificity and potency of N-methyl-D-aspartate glycine site antagonists and of mephenesin on the rat spinal cord in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Glycine; Ibotenic Acid; Indoles; Kynurenic Acid; Mephenesin; N-Methylaspartate; Pyrrolidinones; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1992 |
Stimulation of noradrenaline release in human cerebral cortex mediated by N-methyl-D-aspartate (NMDA) and non-NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Glycine; Humans; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Tritium | 1992 |
Modulation of excitatory amino acid responses in rat dorsal horn neurons by tachykinins.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Calcium; Cesium; Colforsin; Glycine; Ibotenic Acid; In Vitro Techniques; N-Methylaspartate; Neurokinin A; Neurons; Peptides; Phorbol Esters; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Substance P; Tachykinins | 1992 |
Characterization of indole-2-carboxylate derivatives as antagonists of N-methyl-D-aspartate receptor activity at the associated glycine recognition site.
Topics: Animals; Binding Sites; Carboxylic Acids; Dizocilpine Maleate; Gerbillinae; Glycine; Indoles; Ischemia; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1992 |
Glycine is required for NMDA receptor activation: electrophysiological evidence from intact rat hippocampus.
Topics: Animals; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Evoked Potentials; Glycine; Hippocampus; Iontophoresis; Ketamine; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Time Factors | 1992 |
Glycine enhances extracellular 45Ca2+ response to NMDA application investigated with microdialysis of rabbit hippocampus in vivo.
Topics: Amino Acids; Animals; Calcium; Calcium Radioisotopes; Dialysis; Drug Synergism; Extracellular Space; Glycine; Hippocampus; Kynurenic Acid; N-Methylaspartate; Rabbits; Receptors, N-Methyl-D-Aspartate; Serine | 1992 |
Ontogeny of N-methyl-D-aspartate-induced current in cultured hippocampal neurons.
Topics: Animals; Cells, Cultured; Cellular Senescence; Chlorides; Dose-Response Relationship, Drug; Electrophysiology; Fetus; Glycine; Hippocampus; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Zinc; Zinc Compounds | 1992 |
Developmental change of the inhibition by lead of NMDA-activated currents in cultured hippocampal neurons.
Topics: Animals; Cells, Cultured; Cellular Senescence; Electrophysiology; Fetus; Glycine; Hippocampus; Lead; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate | 1992 |
Synaptic pharmacology of the superior olivary complex studied in mouse brain slice.
Topics: Amino Acids; Animals; Electric Stimulation; Glycine; In Vitro Techniques; Mice; Mice, Inbred C57BL; N-Methylaspartate; Olivary Nucleus; Pons; Strychnine; Synapses | 1992 |
Glycine and GABA potentiate 4-aminopyridine and/or N-methyl-D-aspartate induced [3H]-noradrenaline release from rat hippocampal slices.
Topics: 4-Aminopyridine; Animals; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Hippocampus; In Vitro Techniques; N-Methylaspartate; Norepinephrine; Rats | 1992 |
4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor.
Topics: Aminoquinolines; Animals; Binding Sites; Cell Membrane; Cerebral Cortex; Glycine; Kynurenic Acid; Models, Molecular; Molecular Conformation; Molecular Structure; N-Methylaspartate; Quinolines; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1992 |
Chronic exposure of cerebellar granule cells to ethanol results in increased N-methyl-D-aspartate receptor function.
Topics: Amyloid beta-Protein Precursor; Animals; Calcium; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Ethanol; Extracellular Space; Glycine; Kinetics; N-Methylaspartate; Potassium Chloride; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical | 1992 |
A comparison of intact and in-vitro locomotion in an adult amphibian.
Topics: Animals; Electromyography; Forelimb; Gait; Glycine; In Vitro Techniques; Isomerism; Locomotion; Muscles; N-Methylaspartate; Necturus | 1992 |
Enhancement of NMDA-evoked neuronal activity by glycine in the rat spinal cord in vivo.
Topics: Animals; Glycine; Iontophoresis; Male; N-Methylaspartate; Neurons; Nociceptors; Rats; Rats, Inbred Strains; Spinal Cord; Strychnine | 1992 |
Modulation of NMDA excitotoxicity by redox reagents.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Dithionitrobenzoic Acid; Dithiothreitol; Embryo, Mammalian; Glycine; N-Methylaspartate; Neurons; Neurotoxins; Oxidation-Reduction; Pipecolic Acids; Rats; Xanthine; Xanthine Oxidase; Xanthines | 1992 |
Arylamine toxins from funnel-web spider (Agelenopsis aperta) venom antagonize N-methyl-D-aspartate receptor function in mammalian brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Calcium; Cells, Cultured; Cerebellum; Cytosol; Evoked Potentials; Glycine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Spider Venoms; Structure-Activity Relationship; Synapses; Synaptic Transmission | 1991 |
1,10-bis(guanidino)decane inhibits N-methyl-D-aspartate responses in vitro and in vivo.
Topics: Animals; Calcium; Cells, Cultured; Cyclic GMP; Dizocilpine Maleate; Glycine; Guanidines; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Prosencephalon; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 1991 |
Excitatory amino acid binding sites in the caudate nucleus and frontal cortex of Huntington's disease.
Topics: Adolescent; Adult; Age Factors; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Binding, Competitive; Caudate Nucleus; Cell Death; Child; Dizocilpine Maleate; Frontal Lobe; Glycine; Humans; Huntington Disease; Ibotenic Acid; Kainic Acid; Middle Aged; N-Methylaspartate; Phencyclidine; Receptors, AMPA; Receptors, Glutamate; Receptors, Glycine; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1991 |
Redox modulatory site of the NMDA receptor-channel complex: regulation by oxidized glutathione.
Topics: Animals; Calcium; Calcium Channels; Cerebral Cortex; Dithionitrobenzoic Acid; Electric Conductivity; Embryo, Mammalian; Fura-2; Glutathione; Glutathione Disulfide; Glycine; Kinetics; Membrane Potentials; N-Methylaspartate; Neurons; Oxidation-Reduction; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Effects of two volatile anesthetics and a volatile convulsant on the excitatory and inhibitory amino acid responses in dissociated CNS neurons of the rat.
Topics: Amino Acids; Animals; Brain Stem; Dose-Response Relationship, Drug; Electrophysiology; Enflurane; Flurothyl; gamma-Aminobutyric Acid; Glutamates; Glycine; Halothane; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Neurotransmitter | 1991 |
Dual effect of glycine on isolated rat suprachiasmatic neurons.
Topics: Animals; Electrophysiology; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Inbred Strains; Strychnine; Suprachiasmatic Nucleus | 1991 |
L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes.
Topics: 2-Amino-5-phosphonovalerate; Alzheimer Disease; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glycine; Kainic Acid; N-Methylaspartate; Phosphoserine; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1991 |
Electrophysiological evidence for the presence of NMDA receptors in the guinea pig cochlea.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Action Potentials; Animals; Auditory Pathways; Cochlea; Cochlear Microphonic Potentials; Electrophysiology; Female; Glycine; Guinea Pigs; Magnesium; Male; N-Methylaspartate; Neurotransmitter Agents; Receptors, N-Methyl-D-Aspartate | 1991 |
Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-methyl-D-aspartate receptor agonist responses in rat cultured cortical neurons.
Topics: Animals; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Osmolar Concentration; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate; Sodium | 1991 |
Selective blockade of non-NMDA receptors does not block rapidly triggered glutamate-induced neuronal death.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cell Line; Cell Survival; Cerebral Cortex; Fetus; Glutamates; Glutamic Acid; Glycine; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
Excitatory amino acid receptor-channels in Purkinje cells in thin cerebellar slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Cerebellum; Evoked Potentials; Glutamates; Glycine; Ibotenic Acid; In Vitro Techniques; Magnesium; Membrane Potentials; N-Methylaspartate; Purkinje Cells; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission; Tetrodotoxin | 1991 |
Glutamate neurotoxicity in spinal cord cell culture.
Topics: Animals; Cells, Cultured; Dextromethorphan; Dextrorphan; Glutamates; Glutamic Acid; Glycine; N-Methylaspartate; Neurons; Spinal Cord | 1991 |
In vivo study of NMDA-sensitive glutamate receptor by fluorothienylcyclohexylpiperidine [correction of fluorothienylcycloexylpiperidine], a possible ligand for positron emission tomography.
Topics: Animals; Binding Sites; Brain; Cerebral Cortex; Corpus Striatum; Glutamates; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Injections, Intravenous; Macaca mulatta; Male; Mice; N-Methylaspartate; Piperidines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Membranes; Tomography, Emission-Computed | 1991 |
N-methyl-D-aspartate and aspartate raise the cytosolic free calcium concentration by acting upon receptors transiently expressed on immature cerebellar Purkinje cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn; Aspartic Acid; Calcium; Cerebellum; Cytosol; Gallopamil; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Magnesium; N-Methylaspartate; Organophosphorus Compounds; Piperazines; Purkinje Cells; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
An arthropod NMDA receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Astacoidea; Cesium; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Immunoenzyme Techniques; Interneurons; Kynurenic Acid; Magnesium; Membrane Potentials; N-Methylaspartate; Photic Stimulation; Receptors, N-Methyl-D-Aspartate; Vision, Ocular | 1991 |
Stimulation of noradrenaline release in the cerebral cortex via presynaptic N-methyl-D-aspartate (NMDA) receptors and their pharmacological characterization.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Magnesium; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1991 |
Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead.
Topics: Animals; Aspartic Acid; Calcium; Dibenzocycloheptenes; Dizocilpine Maleate; Electric Conductivity; Glycine; Hippocampus; Ion Channels; Kainic Acid; Lead; Learning Disabilities; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Glycine decreases desensitization of N-methyl-D-aspartate (NMDA) receptors expressed in Xenopus oocytes and is required for NMDA responses.
Topics: Animals; Aspartic Acid; Brain; Calcium; Electric Conductivity; Female; Glycine; Kinetics; Membrane Potentials; N-Methylaspartate; Oocytes; Poly A; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA; RNA, Messenger; Xenopus laevis | 1990 |
Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding Sites; Cerebellum; Electric Conductivity; Glycine; Hydrogen-Ion Concentration; Ibotenic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Protons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
A radiohistochemical measure of [3H]TCP binding to the activated NMDA-receptor-gated ion channel in rat brain.
Topics: Animals; Aspartic Acid; Brain; Glycine; Ion Channels; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Modulation of the N-methyl-D-aspartate channel by extracellular H+.
Topics: Animals; Aspartic Acid; Cells, Cultured; Embryo, Mammalian; gamma-Aminobutyric Acid; Glycine; Hippocampus; Hydrogen-Ion Concentration; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Neurotoxins; Oxadiazoles; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Regulation of [3H]dopamine release from guinea pig striatum by NMDA receptor/channel activators and inhibitors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Corpus Striatum; Dopamine; Glycine; Guinea Pigs; Ion Channels; Magnesium; Male; N-Methylaspartate; Piperazines; Pyrrolidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid | 1990 |
Glycine site-directed agonists reverse the actions of ethanol at the N-methyl-D-aspartate receptor.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; Ethanol; Glycine; Isoleucine; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Sarcosine | 1990 |
Polyamines potentiate responses of N-methyl-D-aspartate receptors expressed in xenopus oocytes.
Topics: Animals; Brain; Female; Glycine; Kinetics; Male; Membrane Potentials; N-Methylaspartate; Oocytes; Poly A; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; RNA; RNA, Messenger; Spermine; Xenopus laevis | 1990 |
Proteolytic enzymes do not destroy the N-methyl-D-aspartate (NMDA) sensitivity of acutely isolated hippocampal CA1 and CA3 neurons from postnatal rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Aspartic Acid; Cell Separation; Dose-Response Relationship, Drug; Drug Synergism; Electric Conductivity; Glycine; Hippocampus; Ion Channels; Magnesium; N-Methylaspartate; Neurons; Peptide Hydrolases; Rats | 1990 |
Mechanism of inhibition of N-methyl-D-aspartate-stimulated increases in free intracellular Ca2+ concentration by ethanol.
Topics: Animals; Brain; Calcium; Dizocilpine Maleate; Ethanol; Glycine; Intracellular Membranes; Ion Channels; N-Methylaspartate; Neurons; Osmolar Concentration; Phencyclidine | 1991 |
Competitive antagonists and partial agonists at the glycine modulatory site of the mouse N-methyl-D-aspartate receptor.
Topics: Action Potentials; Animals; Brain; Cells, Cultured; Cerebral Cortex; Cycloserine; Diencephalon; Glycine; Ion Channels; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate | 1990 |
GABA release from mouse striatal neurons in primary culture as a test for the functional activity of N-methyl-D-aspartate (NMDA) antagonists.
Topics: Animals; Cells, Cultured; Corpus Striatum; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Ion Channels; Kynurenic Acid; Ligands; Mice; N-Methylaspartate; Neurons; Pregnancy; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Use of a conflict procedure in pigeons to characterize anxiolytic drug activity: evaluation of N-methyl-D-aspartate antagonists.
Topics: Animals; Anti-Anxiety Agents; Binding Sites; Columbidae; Conflict, Psychological; Female; Glycine; Ion Channels; Male; N-Methylaspartate; Punishment; Receptors, N-Methyl-D-Aspartate; Stress, Physiological | 1991 |
Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Glycine; Ibotenic Acid; Ion Channels; N-Methylaspartate; Piperidines; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Vasodilator Agents | 1991 |
Multiple effects of tetraethylammonium on N-methyl-D-aspartate receptor-channels in mouse brain neurons in cell culture.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Glycine; Ion Channel Gating; Ion Channels; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Quisqualic Acid; Receptors, Cell Surface; Tetraethylammonium; Tetraethylammonium Compounds | 1991 |
[Neurochemistry of the NMDA receptor complex].
Topics: Animals; Binding Sites; Glycine; Ion Channels; N-Methylaspartate; Polyamines; Receptors, Amino Acid; Receptors, Cell Surface | 1991 |
Behavioral sensitization to kainic acid and quisqualic acid in mice: comparison to NMDA and substance P responses.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Behavior, Animal; Capsaicin; Concanavalin A; Drug Tolerance; GABA Antagonists; Glycine; Injections, Spinal; Kainic Acid; Mice; N-Methylaspartate; Quisqualic Acid; Spinal Cord; Substance P | 1991 |
Identification of cardiovascular neurons in the rostral ventromedial medulla in anesthetized rats.
Topics: Animals; Blood Pressure; Cardiovascular System; Glycine; Injections; Male; Medulla Oblongata; Muscle Tonus; N-Methylaspartate; Neurons; Rats; Vasomotor System | 1992 |
Acetylcholine release from the rabbit retina mediated by NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Amino Acids; Animals; Convulsants; Dizocilpine Maleate; Glycine; In Vitro Techniques; Light; Magnesium; N-Methylaspartate; Rabbits; Receptors, N-Methyl-D-Aspartate; Retina | 1991 |
Glutamatergic control of dopamine release in the rat striatum: evidence for presynaptic N-methyl-D-aspartate receptors on dopaminergic nerve terminals.
Topics: Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Drug Synergism; Glutamine; Glycine; Magnesium; Male; N-Methylaspartate; Nerve Endings; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Strychnine; Synaptosomes; Tetrodotoxin | 1991 |
Inhibitory and potentiating influences of glycine on N-methyl-D-aspartate-evoked dopamine release from cultured rat mesencephalic cells.
Topics: Amino Acids; Animals; Cells, Cultured; Dopamine; Extracellular Space; Glycine; Magnesium; Mesencephalon; N-Methylaspartate; Potassium; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Strychnine; Tritium | 1991 |
Initial expression and endogenous activation of NMDA channels in early neocortical development.
Topics: Aging; Animals; Animals, Newborn; Cerebral Cortex; Gestational Age; Glycine; Magnesium; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Glycine microinjected into nucleus tractus solitarii of rat acts through cholinergic mechanisms.
Topics: Acetylcholine; Animals; Blood Pressure; Choline; Glycine; Heart Rate; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; N-Methylaspartate; Physostigmine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate | 1991 |
Endogenous glycine modulates N-methyl-D-aspartate-evoked release of adenosine and [3H]noradrenaline from rat cortical slices.
Topics: Adenosine; Animals; Cerebral Cortex; Glycine; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Strychnine | 1991 |
Effects of nicotinic agonists on the NMDA receptor.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Ganglionic Stimulants; Glycine; Lobeline; N-Methylaspartate; Neurons; Nicotine; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 1991 |
Modulation of N-methyl-D-aspartate receptor-mediated increases in cytosolic calcium in cultured rat cerebellar granule cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Cerebellum; Cytosol; Egtazic Acid; Fura-2; Glycine; Kinetics; N-Methylaspartate; Potassium Chloride; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence | 1991 |
Heterogeneity of N-methyl-D-aspartate receptors regulating the release of dopamine and acetylcholine from striatal slices.
Topics: Acetylcholine; Animals; Corpus Striatum; Dopamine; Glycine; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Opposite effects of spermine and arcaine on responses of N-methyl-D-aspartate receptors expressed in Xenopus oocytes.
Topics: Animals; Biguanides; Glycine; N-Methylaspartate; Oocytes; Polyamines; Receptors, N-Methyl-D-Aspartate; Spermine; Xenopus | 1991 |
Modulation of ethanol-induced inhibition of N-methyl-D-aspartate-stimulated neurotransmitter release by glycine.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Dopamine; Ethanol; Glycine; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley | 1991 |
Rat pup isolation calls are reduced by functional antagonists of the NMDA receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Female; Glycine; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Social Isolation; Vocalization, Animal | 1990 |
N-methyl-D-aspartate recognition site ligands modulate activity at the coupled glycine recognition site.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Glutamates; Glutamic Acid; Glycine; Ligands; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines | 1990 |
Quisqualate activates N-methyl-D-aspartate receptor channels in hippocampal neurons maintained in culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Electric Stimulation; Glycine; Hippocampus; Indoles; Ion Channel Gating; N-Methylaspartate; Neural Conduction; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex.
Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Brain; Cells, Cultured; Drug Interactions; Female; Glycine; Male; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine; Spermine; Spinal Cord | 1990 |
Glutamate and glycine induce a negative wave on hippocampal field response through NMDA receptors.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Glycine; Hippocampus; Male; N-Methylaspartate; Neural Inhibition; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Concentration-jump experiments with NMDA antagonists in mouse cultured hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Aspartic Acid; Cells, Cultured; Glycine; Hippocampus; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Osmolar Concentration; Piperazines | 1990 |
Glycine-insensitive NMDA-sensitive receptor expressed in Xenopus oocytes by guinea pig cerebellar mRNA.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cerebellum; Electric Conductivity; Female; Glycine; Guinea Pigs; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Oocytes; Phencyclidine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1990 |
An electrophysiological study of the action of N-methyl-D-aspartate on excitatory synaptic transmission in the optic tectum of the frog in vitro.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Electrophysiology; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Rana temporaria; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Superior Colliculi; Synapses; Synaptic Transmission | 1990 |
The glycine site modulates NMDA-mediated changes of intracellular free calcium in cultures of hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cells, Cultured; Embryo, Mammalian; Glycine; Hippocampus; Ketamine; Kinetics; Kynurenic Acid; Macromolecular Substances; N-Methylaspartate; Neurons; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1990 |
Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-methyl-D-aspartate receptor complex.
Topics: Allosteric Site; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Hippocampus; Ileum; Isometric Contraction; Kinetics; Male; Muscle, Smooth; N-Methylaspartate; Neurons; Norepinephrine; Pyrrolidinones; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Synaptosomes | 1990 |
The correlation between excitatory amino acid-induced current responses and excitotoxicity in striatal cultures.
Topics: Animals; Cells, Cultured; Corpus Striatum; Glutamates; Glutamic Acid; Glycine; Membrane Potentials; N-Methylaspartate; Neurotransmitter Agents; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
The glycine antagonist 7-chlorokynurenic acid blocks the effects of N-methyl-D-aspartate on agonist-stimulated phosphoinositide hydrolysis in guinea-pig brain slices.
Topics: Animals; Brain; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Hydrolysis; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Phosphatidylinositols; Receptors, N-Methyl-D-Aspartate | 1990 |
Pharmacology of N-methyl-D-aspartate-induced brain injury in an in vivo perinatal rat model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain Diseases; Female; Glycine; Male; N-Methylaspartate; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1990 |
Dual effect of glycine on NMDA-induced neurotoxicity in rat cortical cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Cerebral Cortex; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Kynurenic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Degeneration; Neurons; Oocytes; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Taurine; Xenopus | 1990 |
A topological model of the NMDA-glycine receptor model.
Topics: 2-Amino-5-phosphonovalerate; Glutamates; Glutamic Acid; Glycine; Models, Molecular; N-Methylaspartate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Spinal neuronal pathology associated with continuous intrathecal infusion of N-methyl-D-aspartate in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Glycine; Infusions, Parenteral; Magnesium Sulfate; Male; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Reference Values; Spinal Cord | 1990 |
6,7-Dinitroquinoxaline-2,3-dione and 6-nitro,7-cyanoquinoxaline-2,3-dione antagonize responses mediated by N-methyl-D-aspartate and NMDA-associated glycine recognition sites in vivo: measurements of cerebellar cyclic-GMP.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cerebellum; Cyclic AMP; Glycine; Harmaline; Kinetics; Male; Mice; N-Methylaspartate; Pyrrolidinones; Quinoxalines; Quisqualic Acid; Serine | 1990 |
Augmentation by glycine and blockade by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) of responses to excitatory amino acids in slices of rat neocortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Cerebral Cortex; Drug Interactions; Electrophysiology; Female; Glycine; Homocysteine; Ibotenic Acid; In Vitro Techniques; Kinetics; Male; Membrane Potentials; N-Methylaspartate; Neurons; Quinoxalines; Quisqualic Acid; Rats; Somatosensory Cortex | 1990 |
Ethanol inhibits NMDA-stimulated neurite growth by sensory neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Chick Embryo; Ethanol; Ganglia, Spinal; Glycine; Kynurenic Acid; Magnesium; N-Methylaspartate; Neurites; Neurons, Afferent | 1990 |
Kynurenine and glycine enhance neuronal sensitivity to N-methyl-D-aspartate.
Topics: Animals; Drug Synergism; Glycine; Hippocampus; Kynurenine; Male; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Strychnine | 1991 |
Regional distribution and properties of [3H]MK-801 binding sites determined by quantitative autoradiography in rat brain.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Dizocilpine Maleate; Glycine; Kinetics; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Tissue Distribution; Tritium | 1991 |
Ethanol inhibition of NMDA mediated depolarizations is increased in the presence of Mg2+.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Ethanol; Female; Glycine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Magnesium; N-Methylaspartate; Neuromuscular Depolarizing Agents; Rats; Rats, Inbred Strains | 1991 |
Release-enhancing glycine-dependent presynaptic NMDA receptors exist on noradrenergic terminals of hippocampus.
Topics: Animals; Drug Synergism; Glycine; Hippocampus; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Synaptosomes | 1990 |
alpha-Cobratoxin blocks the nicotinic acetylcholine receptor in rat hippocampal neurons.
Topics: Acetylcholine; Animals; Bacterial Toxins; Cells, Cultured; Cobra Neurotoxin Proteins; Cyanobacteria Toxins; Female; Fetus; Glycine; Hippocampus; Marine Toxins; Membrane Potentials; Microcystins; N-Methylaspartate; Neurons; Nicotinic Antagonists; Pregnancy; Rats; Rats, Inbred Strains | 1990 |
Role of glycine in the N-methyl-D-aspartate-mediated neuronal cytotoxicity.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Serine | 1990 |
3-(2-carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspartate receptor complex.
Topics: Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; Glycine; Hippocampus; Indoles; Molecular Structure; N-Methylaspartate; Propionates; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Strychnine | 1990 |
Serotonin suppresses N-methyl-D-aspartate responses in acutely isolated spinal dorsal horn neurons of the rat.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Drug Synergism; Glycine; In Vitro Techniques; Indoles; Kainic Acid; Ketanserin; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin Antagonists; Spinal Cord; Tetrahydronaphthalenes; Tropisetron | 1990 |
Oxygen free radicals regulate NMDA receptor function via a redox modulatory site.
Topics: Animals; Binding Sites; Calcium; Catalase; Cell Survival; Cells, Cultured; Cerebral Cortex; Dithiothreitol; Electric Conductivity; Free Radicals; Glycine; N-Methylaspartate; Neurons; Oxidation-Reduction; Oxygen; Rats; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase; Xanthine; Xanthine Oxidase; Xanthines | 1990 |
Reduction of NMDA receptors with dithiothreitol increases [3H]-MK-801 binding and NMDA-induced Ca2+ fluxes.
Topics: Animals; Calcium; Dithionitrobenzoic Acid; Dithiothreitol; Dizocilpine Maleate; Fluorescence; Fura-2; Glutamates; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine | 1990 |
5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors.
Topics: Animals; Binding, Competitive; Brain; Evoked Potentials; Female; Glycine; Kinetics; Kynurenic Acid; N-Methylaspartate; Oocytes; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Structure-Activity Relationship; Xenopus | 1990 |
The effect of agonist concentration, membrane voltage and calcium on N-methyl-D-aspartate receptor desensitization.
Topics: Animals; Animals, Newborn; Calcium; Cells, Cultured; Egtazic Acid; Glycine; Hippocampus; Kinetics; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons; Osmolar Concentration; Rats; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Time Factors | 1990 |
The allosteric glycine site of the N-methyl-D-aspartate receptor modulates GABAergic-mediated synaptic events in neonatal rat CA3 hippocampal neurons.
Topics: Aging; Allosteric Regulation; Allosteric Site; Animals; Animals, Newborn; Aspartic Acid; Electric Conductivity; Female; gamma-Aminobutyric Acid; Glycine; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Neurons; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Synapses; Tetrodotoxin | 1990 |
Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.
Topics: 4-Butyrolactone; Acoustic Stimulation; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dopamine; Furans; Glycine; In Vitro Techniques; Isomerism; Kinetics; Male; Membrane Potentials; Mice; Mice, Inbred DBA; Motor Activity; N-Methylaspartate; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reference Values; Seizures; Serotonin | 1990 |
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; Kainic Acid; Kynurenic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Oxadiazoles; Phencyclidine; Pyrrolidinones; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
N-methyl-D-aspartate/phencyclidine receptor complex of rat forebrain: purification and biochemical characterization.
Topics: Animals; Aspartic Acid; Brain; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Glutamates; Glycine; Male; Molecular Weight; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Solubility | 1990 |
Glycine-insensitive desensitization of NMDA responses in cultured mouse embryonic neurons.
Topics: Animals; Aspartic Acid; Cells, Cultured; Electric Conductivity; Electrophysiology; Glycine; Mice; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Ethanol inhibits N-methyl-D-aspartate-stimulated [3H]norepinephrine release from rat cortical slices.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Culture Techniques; Ethanol; Glycine; Magnesium; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin; Valine | 1990 |
Differential modulation of the associated glycine recognition site by competitive N-methyl-D-aspartate receptor antagonists.
Topics: Amino Acids; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Glycine; Male; N-Methylaspartate; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1990 |
Glutamate-receptor-mediated regulation of the cytoplasmic free calcium level in cultured cerebellar granule cells.
Topics: Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Cytoplasm; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glutamates; Glycine; Kainic Acid; Magnesium; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Glycine; Hippocampus; Kainic Acid; Kinetics; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship | 1990 |
Excitatory amino acid response in isolated nucleus tractus solitarii neurons of the rat.
Topics: Amino Acids; Animals; Aspartic Acid; Electrophysiology; Glycine; In Vitro Techniques; Kainic Acid; Medulla Oblongata; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1990 |
Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site.
Topics: Animals; Calcium; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Conantokin-G: a novel peptide antagonist to the N-methyl-D-aspartic acid (NMDA) receptor.
Topics: Amino Acid Sequence; Animals; Conotoxins; Cyclic GMP; Glutamates; Glycine; In Vitro Techniques; Kainic Acid; Molecular Sequence Data; N-Methylaspartate; Peptides, Cyclic; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 1990 |
Interaction of strychnine-insensitive glycine binding with MK-801 binding in brain synaptic membranes.
Topics: Animals; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Interactions; Glycine; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Spinal Cord; Stereoisomerism; Strychnine; Synaptic Membranes | 1990 |
Microionophoretic study with milacemide, a glycine precursor, on mammalian central nervous system cells.
Topics: Acetamides; Animals; Aspartic Acid; Brain; Cats; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glycine; Iontophoresis; Kainic Acid; Monoamine Oxidase Inhibitors; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid | 1990 |
Suppression by extracellular K+ of N-methyl-D-aspartate responses in cultured rat hippocampal neurons.
Topics: Animals; Cells, Cultured; Cesium; Glycine; Hippocampus; Iontophoresis; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Potassium; Quisqualic Acid; Rats | 1990 |
Ethanol inhibition of N-methyl-D-aspartate-stimulated endogenous dopamine release from rat striatal slices: reversal by glycine.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; Dopamine Antagonists; Ethanol; Glycine; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains | 1990 |
Phencyclidine and glycine modulate NMDA-activated high conductance cationic channels by acting at different sites.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebellum; Cerebral Cortex; Electric Conductivity; Glycine; Ion Channels; N-Methylaspartate; Neurons; Phencyclidine; Rats | 1988 |
Structural requirements for activation of the glycine receptor that modulates the N-methyl-D-aspartate operated ion channel.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Glycine; Ion Channels; N-Methylaspartate; Phencyclidine; Rats; Receptors, Glycine; Receptors, Neurotransmitter | 1988 |
Indole-2-carboxylic acid: a competitive antagonist of potentiation by glycine at the NMDA receptor.
Topics: Animals; Aspartic Acid; Carboxylic Acids; Cells, Cultured; Electric Conductivity; Glycine; In Vitro Techniques; Indoles; Ion Channels; N-Methylaspartate; Neural Inhibition; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship | 1989 |
Glycine regulation of the N-methyl-D-aspartate receptor-gated ion channel in hippocampal membranes.
Topics: Allosteric Regulation; Animals; Aspartic Acid; Cell Membrane; Glutamates; Glycine; Hippocampus; In Vitro Techniques; Ion Channels; Kinetics; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Excitatory and inhibitory amino acids and peptide-induced responses in acutely isolated rat spinal dorsal horn neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Drug Synergism; Electric Conductivity; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neuropeptides; Oxadiazoles; Peptides; Quisqualic Acid; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1989 |
Effect of 7-chloro kynurenic acid on glycine modulation of the N-methyl-D-aspartate response in guinea-pig myenteric plexus.
Topics: Animals; Aspartic Acid; Glycine; Guinea Pigs; In Vitro Techniques; Kynurenic Acid; Male; Myenteric Plexus; N-Methylaspartate; Serine | 1989 |
Modulation of glutamate receptors by phencyclidine and glycine in the rat cerebellum: cGMP increase in vivo.
Topics: Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Brain; Cerebellum; Cyclic GMP; Glycine; Injections, Intraventricular; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
In primary cultures of cerebellar granule cells the activation of N-methyl-D-aspartate-sensitive glutamate receptors induces c-fos mRNA expression.
Topics: Animals; Aspartic Acid; Blotting, Northern; Calcium; Cells, Cultured; Cerebellum; Gene Expression Regulation; Glutamates; Glycine; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Oxadiazoles; Phencyclidine; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Transcription, Genetic | 1989 |
Glycine modulation of NMDA-evoked release of [3H]acetylcholine and [3H]dopamine from rat striatal slices.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Glycine; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1989 |
Modulation of NMDA receptor-mediated responses by glycine and D-serine in the rat thalamus in vivo.
Topics: Action Potentials; Animals; Aspartic Acid; Glycine; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Strychnine; Thalamus | 1989 |
N-methyl-D-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Ethanol; Glycine; Granulocytes; N-Methylaspartate; Osmolar Concentration; Phencyclidine; Picrotoxin | 1989 |
Glycine and D-serine act as positive modulators of signal transduction at N-methyl-D-aspartate sensitive glutamate receptors in cultured cerebellar granule cells.
Topics: Animals; Aspartic Acid; Calcium; Calcium Radioisotopes; Cells, Cultured; Cerebellum; Glycine; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Serine; Signal Transduction; Strychnine | 1989 |
Selectivity of quinoxalines and kynurenines as antagonists of the glycine site on N-methyl-D-aspartate receptors.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Biological Assay; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship; Xenopus laevis | 1989 |
Structural requirements for activation of the glycine coagonist site of N-methyl-D-aspartate receptors expressed in Xenopus oocytes.
Topics: Amino Acids; Animals; Aspartic Acid; Binding Sites; Computer Simulation; DNA Mutational Analysis; Dose-Response Relationship, Drug; Glycine; Hydrogen Bonding; Membrane Potentials; Models, Molecular; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Recombinant Proteins; Structure-Activity Relationship; Xenopus laevis | 1989 |
Abolition of the NMDA-mediated responses by a specific glycine antagonist, 6,7-dichloroquinoxaline-2,3-dione (DCQX).
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Brain; Glycine; Kinetics; N-Methylaspartate; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship; Synaptic Membranes | 1989 |
Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines.
Topics: Acetamides; Animals; Aspartic Acid; Brain; Calcium; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glycine; In Vitro Techniques; Ketamine; Kinetics; N-Methylaspartate; Phencyclidine; Piperidines; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Kainate evokes the release of endogenous glycine from striatal neurons in primary culture.
Topics: Animals; Aspartic Acid; Cells, Cultured; Corpus Striatum; Glycine; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
A potent antagonist of the strychnine insensitive glycine receptor has anticonvulsant properties.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Cortical Spreading Depression; Female; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pregnancy; Pyrrolidinones; Quinoxalines; Rats; Receptors, Glycine; Receptors, Neurotransmitter; Seizures; Strychnine | 1989 |
Long-lasting physiological effects of bath applied N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Electric Stimulation; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Spermine; Time Factors; Valine | 1989 |
Modulation of dendritic release of dopamine by N-methyl-D-aspartate receptors in rat substantia nigra.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Dendrites; Dopamine; Glutamates; Glutamic Acid; Glycine; Kainic Acid; Kinetics; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Substantia Nigra; Tetrodotoxin | 1989 |
Effect of impact trauma on neurotransmitter and nonneurotransmitter amino acids in rat spinal cord.
Topics: Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Kinetics; Laminectomy; Male; N-Methylaspartate; Neurotransmitter Agents; Rats; Serine; Spinal Cord; Spinal Cord Injuries; Taurine; Threonine | 1989 |
Interaction of 6-cyano-7-nitroquinoxaline-2,3-dione with the N-methyl-D-aspartate receptor-associated glycine binding site.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cells, Cultured; Glycine; N-Methylaspartate; Quinoxalines; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) antagonizes NMDA-evoked [3H]GABA release from cultured cortical neurons via an inhibitory action at the strychnine-insensitive glycine site.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1989 |
Glycine potentiates the stimulation of inositol phospholipid hydrolysis by excitatory amino acids in primary cultures of cerebellar neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Drug Synergism; Glutamates; Glutamic Acid; Glycine; Hydrolysis; Inositol Phosphates; Magnesium; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Signal Transduction; Sugar Phosphates | 1989 |
Glycine potentiates NMDA responses in rat hippocampal CA1 neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Glycine; Hippocampus; Humans; N-Methylaspartate; Rats; Valine | 1989 |
Actions of excitatory amino acids on somatostatin release from cortical neurons in primary cultures.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Fetus; Glutamates; Glutamic Acid; Glutamine; Glycine; Kinetics; Magnesium; N-Methylaspartate; Neurons; Neurotransmitter Agents; Rats; Somatostatin; Tetrodotoxin; Veratridine | 1989 |
Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Cerebral Cortex; Chromatography, High Pressure Liquid; Electrophysiology; Glutamates; Glycine; Hippocampus; Histocytochemistry; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1989 |
Effects of amygdaloid kindling on NMDA receptor function and regulation.
Topics: Amygdala; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Glycine; Hippocampus; Kindling, Neurologic; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Dilator effects of amino acid neurotransmitters on piglet pial arterioles.
Topics: 6-Ketoprostaglandin F1 alpha; Amino Acids; Animals; Arteries; Arterioles; Aspartic Acid; Blood Pressure; Cerebrovascular Circulation; Dinoprostone; Female; Glutamates; Glutamic Acid; Glycine; Isoproterenol; Male; Muscle, Smooth, Vascular; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Pia Mater; Reference Values; Swine; Taurine | 1989 |
HA-966 acts at a modulatory glycine site to inhibit N-methyl-D-aspartate-evoked neurotransmitter release.
Topics: Animals; Aspartic Acid; Binding Sites; Dibenzocycloheptenes; Dizocilpine Maleate; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Piperazines; Pyrrolidinones; Rats; Strychnine | 1989 |
N-methyl-D-aspartate receptors in the cortex and hippocampus of baboon (Papio anubis and Papio papio).
Topics: Animals; Aspartic Acid; Binding, Competitive; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Hippocampus; N-Methylaspartate; Papio; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Glycine reverses the effect of HA-966 on NMDA responses in cultured rat cortical neurons and in chick retina.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Chickens; Cortical Spreading Depression; Glycine; In Vitro Techniques; N-Methylaspartate; Neurons; Pyrrolidinones; Rats; Retina | 1989 |
Concanavalin A potentiates NMDA-evoked responses in the Xenopus oocyte expression system.
Topics: Animals; Aspartic Acid; Brain; Concanavalin A; Drug Synergism; Gene Expression Regulation; Glycine; In Vitro Techniques; N-Methylaspartate; Oocytes; RNA, Messenger; Stimulation, Chemical; Xenopus | 1989 |
Glycine potentiates the NMDA-induced release of dopamine through a strychnine-insensitive site in the rat striatum.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Drug Synergism; Glycine; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Strychnine | 1989 |
Strychnine-insensitive binding of [3H]glycine to synaptic membranes in rat brain, treated with Triton X-100.
Topics: Animals; Aspartic Acid; Brain Chemistry; Glycine; In Vitro Techniques; Kinetics; N-Methylaspartate; Octoxynol; Polyethylene Glycols; Rats; Rats, Inbred Strains; Strychnine; Synaptic Membranes | 1989 |
Effect of glycine and glycine receptor antagonists on NMDA-induced brain injury.
Topics: Animals; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Glycine; Kynurenic Acid; N-Methylaspartate; Organ Size; Rats; Rats, Inbred Strains | 1989 |
Coexpression of N-methyl-D-aspartate and phencyclidine receptors in Xenopus oocytes injected with rat brain mRNA.
Topics: Animals; Aspartic Acid; Brain Chemistry; Dose-Response Relationship, Drug; Electrophysiology; Glycine; Microinjections; N-Methylaspartate; Oocytes; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; RNA, Messenger; Xenopus laevis | 1988 |
7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Electric Conductivity; Glycine; In Vitro Techniques; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Cycloleucine competitively antagonizes the strychnine-insensitive glycine receptor.
Topics: Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Cycloleucine; Glycine; In Vitro Techniques; Male; N-Methylaspartate; Phencyclidine; Rats; Receptors, Glycine; Receptors, Neurotransmitter; Strychnine | 1988 |
N-methyl-D-aspartate receptor regulation of uncompetitive antagonist binding in rat brain membranes: kinetic analysis.
Topics: Animals; Aspartic Acid; Brain; Glycine; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Serine; Strychnine | 1988 |
Glycine and D-serine increase the affinity of N-methyl-D-aspartate sensitive glutamate binding sites in rat brain synaptic membranes.
Topics: Animals; Aspartic Acid; Brain; Glutamates; Glycine; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Serine; Synaptic Membranes | 1988 |
Effects of bath-applied excitatory amino acids and their analogs on spinal interneurons of the lamprey.
Topics: Amino Acids; Animals; Aspartic Acid; Fishes; Glutamates; Glutamic Acid; Glycine; Homocysteine; In Vitro Techniques; Interneurons; Kainic Acid; Lampreys; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Spinal Cord | 1985 |
Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-aminopyrrolidone-2 (HA-966) but not by D-2-amino-5-phosphonovalerate (D-AP5) on rat cortical slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Evoked Potentials; Glycine; In Vitro Techniques; N-Methylaspartate; Pyrrolidinones; Rats; Valine | 1988 |
Sites of antagonist action on N-methyl-D-aspartic acid receptors studied using fluctuation analysis and a rapid perfusion technique.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Cations, Divalent; Cells, Cultured; Glycine; Hippocampus; Ketamine; Kynurenic Acid; Magnesium; Mice; Mice, Inbred C57BL; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine; Zinc | 1988 |
Glycine potentiates strychnine-induced convulsions: role of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Drug Synergism; Glycine; Injections, Spinal; Mice; N-Methylaspartate; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Strychnine; Valine | 1988 |
Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine.
Topics: Animals; Aspartic Acid; Autoradiography; Binding Sites; Brain; Glutamates; Glutamic Acid; Glycine; Male; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
6,7-Dinitro-quinoxaline-2,3-dion and 6-nitro,7-cyano-quinoxaline-2,3-dion antagonise responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Glycine; In Vitro Techniques; N-Methylaspartate; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Spinal Cord; Strychnine | 1988 |
Properties of two classes of rat brain acidic amino acid receptors induced by distinct mRNA populations in Xenopus oocytes.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Glycine; Kainic Acid; N-Methylaspartate; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; RNA, Messenger; Xenopus laevis | 1988 |
Equilibrium analysis of [3H]TCP binding: effects of glycine, magnesium and N-methyl-D-aspartate agonists.
Topics: Animals; Aspartic Acid; Binding, Competitive; Cerebral Cortex; Dialysis; Glycine; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Synaptosomes | 1988 |
NMDA-induced hippocampal [3H]norepinephrine release is modulated by glycine.
Topics: Animals; Aspartic Acid; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Norepinephrine; Radioligand Assay; Rats | 1988 |
Glycine potentiates N-methyl-D-aspartate-induced [3H]TCP binding to rat cortical membranes.
Topics: Animals; Aspartic Acid; Cell Membrane; Cerebral Cortex; Drug Synergism; Electric Stimulation; Glycine; In Vitro Techniques; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains | 1987 |
Effects of intranigral injections of dopamine agonists and antagonists, glycine, muscimol and N-methyl-D,L-aspartate on locomotor activity.
Topics: Amphetamine; Animals; Antipsychotic Agents; Aspartic Acid; Brain Mapping; Dopamine; Glycine; Male; Motor Activity; Muscimol; N-Methylaspartate; Rats; Rats, Inbred Strains; Substantia Nigra | 1984 |
Evidence that inhibitory mechanisms mask inappropriate somatotopic connections in the spinal cord of normal rat.
Topics: Afferent Pathways; Animals; Electric Stimulation; Evoked Potentials, Somatosensory; Glutamic Acid; Glycine; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; Strychnine; Time Factors | 1995 |
Glycine modulates ethanol inhibition of heteromeric N-methyl-D-aspartate receptors expressed in Xenopus oocytes.
Topics: Animals; Chloride Channels; Chlorides; Drug Interactions; Ethanol; Female; Glycine; Kinetics; N-Methylaspartate; Oocytes; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sensitivity and Specificity; Xenopus laevis | 1995 |
Gabapentin actions on ligand- and voltage-gated responses in cultured rodent neurons.
Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Calcium Channels; Cells, Cultured; Cerebral Cortex; Cyclohexanecarboxylic Acids; Fetus; Gabapentin; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Ion Channel Gating; Ion Channels; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Neurons, Afferent; Nodose Ganglion; Rats; Sodium Channels; Spinal Cord; Synapses | 1993 |
Protein kinase C activation attenuates N-methyl-D-aspartate-induced increases in intracellular calcium in cerebellar granule cells.
Topics: Alkaloids; Animals; Calcium; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Enzyme Activation; Glycine; Intracellular Fluid; Kinetics; Magnesium Sulfate; N-Methylaspartate; Naphthalenes; Neurons; Pipecolic Acids; Polycyclic Compounds; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Many agents that antagonize the NMDA receptor-channel complex in vivo also cause disturbances of motor coordination.
Topics: Animals; Glycine; Ion Channels; Male; Mice; Motor Activity; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate | 1994 |
Facilitatory effect of docosahexaenoic acid on N-methyl-D-aspartate response in pyramidal neurones of rat cerebral cortex.
Topics: Animals; Arachidonic Acid; Cerebral Cortex; Docosahexaenoic Acids; Electrophysiology; Fatty Acids; Glycine; In Vitro Techniques; Ion Channel Gating; Ion Channels; Magnesium; Membrane Potentials; N-Methylaspartate; Pyramidal Cells; Rats; Rats, Wistar | 1994 |
Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Cricetinae; Cyclic AMP; Glycine; Hydrolysis; Kainic Acid; Kidney; Male; N-Methylaspartate; Phosphatidylinositols; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1994 |
Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acids, Dicarboxylic; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cycloleucine; Cyclopropanes; Glycine; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Phosphatidylinositols; Receptors, Metabotropic Glutamate | 1994 |
Neuroprotective effect of hypothermia in cortical cultures exposed to oxygen-glucose deprivation or excitatory amino acids.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Cold Temperature; Cytosol; Dizocilpine Maleate; Fetus; Glucose; Glutamic Acid; Glycine; Hypothermia, Induced; Kainic Acid; Kinetics; Mice; N-Methylaspartate; Neurons | 1994 |
Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands.
Topics: Acetates; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Membrane; Cerebral Cortex; Dizocilpine Maleate; Glycine; Hydrogen Bonding; Isoxazoles; Ligands; Molecular Conformation; Molecular Structure; N-Methylaspartate; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Structure-Activity Relationship; Thermodynamics | 1994 |
Allosteric regulation of the N-methyl-D-aspartate receptor-linked ion channel complex and effects of ethanol in ethanol-withdrawal seizure-prone and -resistant mice.
Topics: Allosteric Regulation; Animals; Cerebral Cortex; Dizocilpine Maleate; Ethanol; Genetic Predisposition to Disease; Glycine; Hippocampus; Ion Channels; Male; Mice; Mice, Mutant Strains; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Seizures; Spermidine; Substance Withdrawal Syndrome | 1995 |
Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Felbamate; Female; Glycine; Injections, Intraperitoneal; Injections, Intraventricular; Kynurenic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Phenylcarbamates; Propylene Glycols; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Stereoisomerism; Synaptic Transmission | 1994 |
NMDA and non-NMDA receptor-mediated release of [3H]GABA from granule cell dendrites of rat olfactory bulb.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dendrites; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glycine; Granulocytes; Kainic Acid; Male; N-Methylaspartate; Olfactory Bulb; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1995 |
Early in vitro development of voltage- and transmitter-gated currents in GABAergic amacrine cells.
Topics: Animals; Autoradiography; Cells, Cultured; Cellular Senescence; Chick Embryo; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Interneurons; Ion Channel Gating; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Quisqualic Acid; Receptors, GABA; Receptors, Glutamate; Retina; Time Factors; Tritium | 1994 |
Abscisic acid potentiates NMDA-gated currents in hippocampal neurones.
Topics: Abscisic Acid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Electric Conductivity; Glycine; Hippocampus; Ion Channel Gating; Ion Channels; Male; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Time Factors | 1994 |
Glycine release from hippocampal slices in developing and ageing mice: modulation by glutamatergic receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Dizocilpine Maleate; Female; Glycine; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; N-Methylaspartate; Potassium; Quisqualic Acid; Receptors, Glutamate; Tetrazoles | 1994 |
Effects of the epileptogenic agent strychnine on membrane currents elicited by agonists of the NMDA and non-NMDA receptors in Xenopus oocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Glycine; Ion Channels; Kainic Acid; N-Methylaspartate; Oocytes; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Strychnine; Xenopus laevis | 1995 |
Modulation by sigma ligands of intracellular free Ca++ mobilization by N-methyl-D-aspartate in primary culture of rat frontal cortical neurons.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium; Cells, Cultured; Cerebral Cortex; Dopamine D2 Receptor Antagonists; Drug Interactions; Female; Glycine; Haloperidol; Intracellular Fluid; Ligands; Magnesium; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Pregnancy; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 1995 |
Modulation by magnesium of the affinity of NMDA receptors for glycine in murine hippocampal neurones.
Topics: Animals; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Hippocampus; In Vitro Techniques; Ion Channel Gating; Kynurenic Acid; Magnesium; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1995 |
Ethanol inhibits NMDA-induced toxicity and trophism in cultured cerebellar granule cells.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; Chlorides; Culture Media; Ethanol; Glutamic Acid; Glycine; N-Methylaspartate; Neurons; Neurotoxins; Potassium; Rats; Rats, Wistar; Time Factors; Tropism | 1995 |
Glycine-independent and subunit-specific potentiation of NMDA responses by extracellular Mg2+.
Topics: Animals; Barium; Calcium; Cell Line; Drug Synergism; Electric Conductivity; Embryo, Mammalian; Embryo, Nonmammalian; Female; Glycine; Humans; Hydrogen-Ion Concentration; Kidney; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Oocytes; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spermine; Xenopus | 1995 |
G-protein modulation of glycine-resistant NMDA receptor desensitization in rat cultured hippocampal neurons.
Topics: Animals; Calcium; Cells, Cultured; Glycine; GTP-Binding Proteins; Guanosine Triphosphate; Hippocampus; Membrane Potentials; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1995 |
Glycine-induced CA1 excitotoxicity in the rat hippocampal slice.
Topics: Animals; Anticonvulsants; Evoked Potentials; Felbamate; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Phenylcarbamates; Propylene Glycols; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 1995 |
Functional and binding properties of sigma receptors in rat cerebellum.
Topics: Animals; Binding, Competitive; Cerebellum; Cyclohexylamines; Female; Glycine; Haloperidol; Male; N-Methylaspartate; Norepinephrine; Pentazocine; Piperidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Stereoisomerism | 1995 |
Involvement of divalent ions in the nitric oxide-induced blockade of N-methyl-D-aspartate receptors in cerebellar granule cells.
Topics: Animals; Cations, Divalent; Cells, Cultured; Cerebellum; Glycine; Hydrogen-Ion Concentration; Membrane Potentials; Mice; Molsidomine; N-Methylaspartate; Neurons; Nitric Oxide; Oxidation-Reduction; Receptors, N-Methyl-D-Aspartate | 1995 |
Calcium-dependent glutamate release during neuronal development and synaptogenesis: different involvement of omega-agatoxin IVA- and omega-conotoxin GVIA-sensitive channels.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cadmium; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Differentiation; Cells, Cultured; Fetus; Glutamic Acid; Glycine; Hippocampus; Kinetics; Magnesium; N-Methylaspartate; Neurons; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Rats; Receptors, N-Methyl-D-Aspartate; Spider Venoms; Synapses; Time Factors | 1995 |
The use of neuronal networks on multielectrode arrays as biosensors.
Topics: Animals; Biosensing Techniques; Electronic Data Processing; gamma-Aminobutyric Acid; Glycine; Mice; N-Methylaspartate; Nerve Net; Neurons; Transfection | 1995 |
Felbamate, a novel antiepileptic drug, reverses N-methyl-D-aspartate/glycine-stimulated increases in intracellular Ca2+ concentration.
Topics: Animals; Anticonvulsants; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Felbamate; Glycine; Hippocampus; N-Methylaspartate; Phenylcarbamates; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 1995 |
Block of the N-methyl-D-aspartate receptor by phencyclidine-like drugs is influenced by alternative splicing.
Topics: Alternative Splicing; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Gene Expression; Glycine; Ketamine; Kinetics; N-Methylaspartate; Oocytes; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Xenopus | 1995 |
Pb2+ reduces voltage- and N-methyl-D-aspartate (NMDA)-activated calcium channel currents.
Topics: Animals; Animals, Newborn; Aspartic Acid; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dose-Response Relationship, Drug; Ganglia, Spinal; Glycine; Kinetics; Lead; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Time Factors | 1994 |
Glutamate receptor-mediated calcium surges in neurons derived from P19 cells.
Topics: Animals; Calcium; Cell Differentiation; Dizocilpine Maleate; Egtazic Acid; Embryonal Carcinoma Stem Cells; Glutamic Acid; Glycine; Kainic Acid; Magnesium; Mice; N-Methylaspartate; Neoplastic Stem Cells; Neurons; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Tretinoin; Tumor Cells, Cultured | 1995 |
SB 201823-A antagonizes calcium currents in central neurons and reduces the effects of focal ischemia in rats and mice.
Topics: Animals; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebellum; Cerebral Infarction; Disease Models, Animal; Glycine; Hippocampus; Ischemic Attack, Transient; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Piperidines; Potassium Chloride; Rats; Rats, Inbred F344; Rats, Inbred Strains; Rats, Sprague-Dawley | 1995 |
Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium.
Topics: Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Dizocilpine Maleate; Egtazic Acid; Endopeptidases; Glycine; Hippocampus; Ion Channels; N-Methylaspartate; Neurons; Phosphoric Monoester Hydrolases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Binding of [3H]MK-801, NMDA-displaceable [3H]glutamate, [3H]glycine, [3H]spermidine, [3H]kainate and [3H]AMPA to regionally discrete brain membranes of the gerbil: a biochemical study.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain; Cell Membrane; Dizocilpine Maleate; Female; Gerbillinae; Glutamates; Glutamic Acid; Glycine; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Receptors, Glutamate; Spermidine; Thiocyanates; Tissue Distribution | 1993 |
Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cerebral Cortex; Cycloleucine; Glycine; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Neurotoxins; Phosphatidylinositols; Rats; Receptors, Glutamate; Spinal Cord; Thalamus | 1993 |
Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Base Sequence; DNA, Neoplasm; Glutamates; Glutamic Acid; Glycine; Humans; Ion Channels; Kinetics; Magnesium; Membrane Potentials; Molecular Sequence Data; N-Methylaspartate; Neurons; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; RNA, Neoplasm; Sequence Homology, Amino Acid; Teratoma; Tumor Cells, Cultured | 1993 |
beta-Amyloid (25-35) or substance P stimulates [3H]MK-801 binding to rat cortical membranes in the presence of glutamate and glycine.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Biguanides; Cell Membrane; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Molecular Sequence Data; N-Methylaspartate; Peptide Fragments; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid; Substance P | 1993 |
Non-NMDA-mediated transmission of somatosensory-evoked potentials in the rat thalamus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Anticonvulsants; Electric Stimulation; Evoked Potentials, Somatosensory; Glycine; Ibotenic Acid; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Wistar; Somatosensory Cortex; Stereotaxic Techniques; Synaptic Transmission; Thalamic Nuclei | 1993 |
Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Electrophysiology; Glycine; Hippocampus; Ibotenic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine | 1993 |
Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Cloning, Molecular; Dizocilpine Maleate; DNA; Female; Frontal Lobe; Gene Library; Glutamates; Glutamic Acid; Glycine; Humans; Ibotenic Acid; Kainic Acid; Macromolecular Substances; Molecular Sequence Data; N-Methylaspartate; Oocytes; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sequence Homology, Amino Acid; Transcription, Genetic; Xenopus laevis | 1993 |
Voltage- and transmitter-gated currents of all-amacrine cells in a slice preparation of the rat retina.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cobalt; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; In Vitro Techniques; Ion Channel Gating; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Potassium Channels; Quinoxalines; Rats; Receptors, Amino Acid; Retina; Retinal Ganglion Cells; Sodium Channels; Strychnine; Synapses; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin | 1993 |
Caffeine and related compounds block inhibitory amino acid-gated Cl- currents in freshly dissociated rat hippocampal neurones.
Topics: Amino Acids; Animals; Caffeine; Chloride Channels; Egtazic Acid; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Hippocampus; In Vitro Techniques; Ion Channel Gating; Ion Channels; Membrane Proteins; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Xanthines | 1993 |
Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzoates; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; Ibotenic Acid; Motor Neurons; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Neurotoxins; Rats; Spinal Cord; Stereoisomerism; Thalamus | 1993 |
The topographical basis and frequency-dependence in the effect of different compounds on neurogenic contractions of the guinea-pig ileum.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Cisapride; Electric Stimulation; Electrophysiology; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mollusk Venoms; Muscle Contraction; N-Methylaspartate; Neuropeptide Y; omega-Conotoxin GVIA; Peptides; Piperidines; Potassium; Sodium; Synapses | 1993 |
Pregnenolone sulfate potentiation of NMDA-mediated increases in intracellular calcium in cultured chick cortical neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Fura-2; Glycine; N-Methylaspartate; Nimodipine; Pregnenolone; Spermine | 1995 |
Felbamate modulates the strychnine-insensitive glycine receptor.
Topics: Animals; Anticonvulsants; Calcium; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Felbamate; Glycine; Mice; N-Methylaspartate; Phenylcarbamates; Propylene Glycols; Receptors, Glycine; Serine; Strychnine | 1995 |
Excitotoxic activation of the NMDA receptor results in inhibition of calcium/calmodulin kinase II activity in cultured hippocampal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Blotting, Western; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Aggregation; Cells, Cultured; Dizocilpine Maleate; Glutamic Acid; Glycine; Hippocampus; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Kinetics; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Neurotoxins; Peptides; Phosphorylation; Potassium Chloride; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate | 1995 |
Inhibitory effects of pentamidine on N-methyl-D-aspartate (NMDA) receptor/channels in the rat brain.
Topics: Animals; Antiviral Agents; Brain; Calcium Channels; Dizocilpine Maleate; Glycine; Mice; N-Methylaspartate; Nitrendipine; Nitric Oxide; Pentamidine; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Spermine; Xenopus | 1995 |
NMDA-induced whole-cell currents and single channel conductances in tectal neurons during two stages of early development of chicken.
Topics: Animals; Cells, Cultured; Chick Embryo; Glycine; N-Methylaspartate; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Tectum Mesencephali | 1995 |
[Non-ketotic hyperglycinemia].
Topics: Amino Acid Metabolism, Inborn Errors; Blood Glucose; Electroencephalography; Female; Glycine; Humans; Infant; Infant, Newborn; Male; N-Methylaspartate | 1995 |
Metabotropic glutamate receptor agonist DCG-IV as NMDA receptor agonist in immature rat hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Glycine; Hippocampus; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 1994 |
Subtypes of NMDA receptor in neurones cultured from rat brain.
Topics: Animals; Brain; Brain Chemistry; Cells, Cultured; Glycine; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pipecolic Acids; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
NMDA receptors in rat cerebellum and forebrain: subtle differences in pharmacology and modulation.
Topics: Animals; Binding Sites; Cerebellum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Glycine; Male; Models, Neurological; N-Methylaspartate; Pipecolic Acids; Prosencephalon; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1995 |
Interleukin-1 modulates GABAergic and glutamatergic function in brain.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain; Calcium; Cells, Cultured; Chick Embryo; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Interleukin-1; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Recombinant Proteins; Spermine; Tumor Necrosis Factor-alpha | 1994 |
NMDA-mediated potentiation of the afferent synapse in the inner ear.
Topics: 2-Amino-5-phosphonovalerate; Ambystoma; Amplifiers, Electronic; Animals; Dizocilpine Maleate; Electrophysiology; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Neurons, Afferent; Physical Stimulation; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Synapses; Vestibule, Labyrinth | 1994 |
Brain regional differences in glycine reversal of ethanol-induced inhibition of N-methyl-D-aspartate-stimulated neurotransmitter release.
Topics: Animals; Brain; Dopamine; Ethanol; Glycine; In Vitro Techniques; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1995 |
Glutamate-induced intracellular calcium changes and neurotoxicity in cortical neurons in vitro: effect of chemical ischemia.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cell Hypoxia; Cells, Cultured; Dizocilpine Maleate; Glutamic Acid; Glycine; Kainic Acid; N-Methylaspartate; Neurons; Nimodipine; Potassium Chloride; Potassium Cyanide; Prosencephalon; Rats; Rats, Sprague-Dawley | 1994 |
Volatile anesthetics inhibit NMDA-stimulated 45Ca uptake by rat brain microvesicles.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Calcium; Calcium Radioisotopes; Dizocilpine Maleate; Enflurane; Glycine; Halothane; Kinetics; Male; Microcirculation; N-Methylaspartate; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
N-methyl-D-aspartic acid/glycine interactions on the control of 5-hydroxytryptamine release in raphe primary cultures.
Topics: Animals; Cells, Cultured; Embryo, Mammalian; Female; Gestational Age; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; N-Methylaspartate; Pregnancy; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Rhombencephalon; Serotonin; Strychnine; Valine | 1993 |
nMDA receptor activation increases cyclic AMP in area CA1 of the hippocampus via calcium/calmodulin stimulation of adenylyl cyclase.
Topics: 2-Amino-5-phosphonovalerate; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenylyl Cyclases; Animals; Ascorbic Acid; Calcium; Calmodulin; Cell Membrane; Colforsin; Cyclic AMP; Deoxyadenosines; Dopamine; Enzyme Activation; Evoked Potentials; Glycine; Hippocampus; In Vitro Techniques; Isoproterenol; Kinetics; Models, Neurological; N-Methylaspartate; Pyramidal Tracts; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Sulfonamides; Theophylline; Trifluoperazine | 1993 |
Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Electrophysiology; Glycine; Kinetics; Membrane Potentials; N-Methylaspartate; Oocytes; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA, Messenger; Xenopus laevis | 1993 |
Neurochemical and electrophysiological studies on FR115427, a novel non-competitive NMDA receptor antagonist.
Topics: Action Potentials; Animals; Binding, Competitive; Cerebral Cortex; Dizocilpine Maleate; Electrophysiology; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Isoquinolines; Male; N-Methylaspartate; Neurons; Pyramidal Cells; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Synaptic Transmission; Tetrahydroisoquinolines | 1993 |
A comparison of the effects of ethanol and the competitive glycine antagonist 7-chlorokynurenic acid on N-methyl-D-aspartic acid-induced neurotransmitter release from rat hippocampal slices.
Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Sprague-Dawley; Serine | 1994 |
Evidence for NMDA receptor in the afferent synaptic transmission of the vestibular system.
Topics: 2-Amino-5-phosphonovalerate; Ambystoma; Animals; Glycine; Hair Cells, Auditory; In Vitro Techniques; Kynurenic Acid; Magnesium; N-Methylaspartate; Nerve Fibers; Neurons, Afferent; Receptors, N-Methyl-D-Aspartate; Semicircular Canals; Synapses; Synaptic Transmission; Vestibule, Labyrinth | 1994 |
Heterocarrier-mediated reciprocal modulation of glutamate and glycine release in rat cerebral cortex and spinal cord synaptosomes.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium; Spinal Cord; Synaptosomes | 1994 |
Modulation of muscarinic cholinoceptor-stimulated inositol 1,4,5-trisphosphate accumulation by N-methyl-D-aspartate in neonatal rat cerebral cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Carbachol; Cerebral Cortex; Dizocilpine Maleate; Female; Glycine; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Magnesium; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Muscarinic | 1994 |
Presence of N-methyl-D-aspartate (NMDA) receptors in neuroblastoma x glioma hybrid NG108-15 cells-analysis using [45Ca2+]influx and [3H]MK-801 binding as functional measures.
Topics: Calcium Radioisotopes; Cations, Divalent; Dizocilpine Maleate; Glioma; Glutamates; Glutamic Acid; Glycine; Hybrid Cells; N-Methylaspartate; Neuroblastoma; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Spermine; Tritium | 1994 |
Density of NMDA-coupled and uncoupled 1-[1-(2-[3H]thienyl) cyclohexyl]piperidine recognition sites in the brain and spinal cord: differential effects of NMDA agonists and antagonists.
Topics: Animals; Binding Sites; Brain; Brain Chemistry; Dizocilpine Maleate; Glutamic Acid; Glycine; Haloperidol; Male; Mice; N-Methylaspartate; Phencyclidine; Spinal Cord; Tritium | 1994 |
Preferential induction by stress of the N-methyl-D-aspartate recognition domain in discrete structures of rat brain.
Topics: 2-Amino-5-phosphonovalerate; Adrenal Cortex Hormones; Animals; Autoradiography; Behavior, Animal; Brain Chemistry; Cerebellum; Corpus Striatum; Cycloheximide; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glycine; Hypothalamus; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Stress, Physiological; Tritium | 1994 |
Release of [3H]GABA evoked by glutamate agonists from hippocampal slices: effects of dithiothreitol and glutathione.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Animals; Dithiothreitol; Dizocilpine Maleate; GABA Agonists; gamma-Aminobutyric Acid; Glutathione; Glycine; Hippocampus; In Vitro Techniques; Kinetics; Magnesium; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Tritium | 1994 |
Effects of prenatal ethanol exposure on N-methyl-D-aspartate-mediated calcium entry into dissociated neurons.
Topics: Animals; Brain; Calcium; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Female; Fetus; Glycine; Magnesium; Male; N-Methylaspartate; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Alaproclate acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow.
Topics: Alanine; Animals; Antidepressive Agents; Calcium; Cells, Cultured; Cerebellum; Glycine; Magnesium; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors | 1994 |
Physiological roles of glycine and gamma-aminobutyric acid in dissociated neurons of rat visual cortex.
Topics: Animals; Bicuculline; Chloride Channels; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Strychnine; Visual Cortex | 1994 |
Synergism between the NMDA receptor antagonistic effects of ifenprodil and the glycine antagonist, 7-chlorokynurenate, in vivo.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Synergism; Glycine; Injections; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1994 |
Modulation of glycine affinity for NMDA receptors by extracellular Ca2+ in trigeminal neurons.
Topics: Animals; Binding, Competitive; Calcium; Drug Synergism; Electrophysiology; Extracellular Space; Glycine; N-Methylaspartate; Neurons; Osmolar Concentration; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Trigeminal Nucleus, Spinal | 1994 |
Selective antagonism of the anticonvulsant effects of felbamate by glycine.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Felbamate; Glycine; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Phenylcarbamates; Propylene Glycols; Seizures | 1994 |
Regulation of D-aspartate release by glutamate and GABA receptors in cerebral cortical slices from developing and ageing mice.
Topics: Aging; Animals; Aspartic Acid; Cerebellum; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Kainic Acid; Male; Mice; N-Methylaspartate; Quisqualic Acid; Receptors, GABA; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Taurine | 1994 |
Long-lasting potentiation of synaptic transmission in the Schaffer collateral-commissural pathway of the guinea pig hippocampus by activation of postsynaptic N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electric Stimulation; Evoked Potentials; Glycine; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Spermine; Synapses; Synaptic Transmission | 1993 |
NMDA-like receptors in the CNS of molluscs.
Topics: Animals; Ganglia; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Lymnaea; Magnesium; Membrane Potentials; N-Methylaspartate; Nervous System Physiological Phenomena; Neurons; Receptors, N-Methyl-D-Aspartate | 1993 |
Modulation of neuronal migration by NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 4-Chloromercuribenzenesulfonate; Animals; Calcium; Cell Movement; Cerebellum; Dizocilpine Maleate; Egtazic Acid; Glutamates; Glutamic Acid; Glycine; Magnesium; Mice; N-Methylaspartate; Neurons; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 1993 |
Whole cell and single channel analysis of the kinetics of glycine-sensitive N-methyl-D-aspartate receptor desensitization.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cells, Cultured; Female; Glycine; Kinetics; Kynurenic Acid; N-Methylaspartate; Neurons; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Superior Colliculi; Synapses | 1993 |
Glutamate-induced increases in intracellular free Mg2+ in cultured cortical neurons.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Fluorescent Dyes; Fura-2; Glutamates; Glutamic Acid; Glycine; Kainic Acid; Kinetics; Magnesium; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Veratridine | 1993 |
Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan).
Topics: Animals; Cells, Cultured; Dextrorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Embryo, Mammalian; gamma-Aminobutyric Acid; Glycine; Hippocampus; Ketamine; Kinetics; Magnesium; Memantine; Membrane Potentials; N-Methylaspartate; Neurons; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Superior Colliculi | 1993 |
The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin.
Topics: Animals; Animals, Newborn; Brain; Choline O-Acetyltransferase; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glycine; Male; N-Methylaspartate; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tetrazoles | 1994 |
Mutagenesis rescues spermine and Zn2+ potentiation of recombinant NMDA receptors.
Topics: Amino Acid Sequence; Animals; Base Sequence; Drug Synergism; Electrophysiology; Female; Glycine; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylaspartate; Oocytes; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spermine; Transfection; Xenopus; Zinc | 1994 |
Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A.
Topics: Cells, Cultured; Ethers, Cyclic; Glycine; Hippocampus; Marine Toxins; Membrane Potentials; N-Methylaspartate; Neurons; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Receptors, N-Methyl-D-Aspartate | 1994 |
Increased activation of L-type voltage-dependent calcium channels is associated with glycine enhancement of N-methyl-D-aspartate-stimulated dopamine release in global cerebral ischemia/reperfusion.
Topics: Animals; Brain Ischemia; Calcium Channels; Dogs; Dopamine; Female; Glycine; Isradipine; N-Methylaspartate; Nitrendipine; Reperfusion Injury; Time Factors; Tritium | 1994 |
Phenytoin blocks N-methyl-D-aspartate responses of mouse central neurons.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Glycine; In Vitro Techniques; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Phenytoin; Potassium; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tetrodotoxin | 1993 |
Molecular basis for regionally specific action of ethanol on gamma-aminobutyric acidA receptors: generalization to other ligand-gated ion channels.
Topics: Animals; Brain Mapping; Ethanol; Gene Expression; Glycine; In Situ Hybridization; Ion Channel Gating; Male; N-Methylaspartate; Nicotine; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA; RNA, Messenger; Zolpidem | 1993 |
Multiple effects of spermine on N-methyl-D-aspartic acid receptor responses of rat cultured hippocampal neurones.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Hippocampus; Kinetics; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Spermine | 1993 |
Diverse modulation by systemic lidocaine of iontophoretic NMDA and quisqualic acid induced excitations on rat dorsal horn neurons.
Topics: Animals; Drug Synergism; Glycine; Injections, Intravenous; Iontophoresis; Kynurenic Acid; Lidocaine; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Strychnine | 1993 |
Histamine potentiates N-methyl-D-aspartate responses in acutely isolated hippocampal neurons.
Topics: Animals; Aspartic Acid; Binding Sites; Calcium; Cell Separation; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Glycine; Hippocampus; Histamine; N-Methylaspartate; Neurons; Osmolar Concentration; Receptors, Histamine; Time Factors | 1993 |
Serine and glycine metabolism in schizophrenic patients.
Topics: Adult; Glycine; Glycine Hydroxymethyltransferase; Humans; Male; N-Methylaspartate; Schizophrenia; Serine | 1993 |
The hypoglycemic sulphonylurea tolbutamide increases N-methyl-D-aspartate- but not kainate-activated currents in hippocampal neurons in culture.
Topics: Animals; Binding Sites; Cells, Cultured; Electrophysiology; Glycine; Hippocampus; Kainic Acid; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Tolbutamide | 1993 |
Allosteric potentiation by diazoxide of AMPA receptor currents and synaptic potentials.
Topics: Allosteric Regulation; Animals; Diazoxide; gamma-Aminobutyric Acid; Glycine; Hippocampus; In Vitro Techniques; Kinetics; Male; Membrane Potentials; N-Methylaspartate; Oocytes; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, AMPA; RNA, Messenger; Synapses; Xenopus | 1993 |
N-acetyl-aspartylglutamate modulation of N-methyl-D-aspartate-stimulated [3H]norepinephrine release from rat hippocampal slices.
Topics: Animals; Calcium Channel Blockers; Dipeptides; Glycine; Hippocampus; In Vitro Techniques; N-Methylaspartate; Norepinephrine; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Effects of intrathecal strychnine and bicuculline on nerve compression-induced thermal hyperalgesia and selective antagonism by MK-801.
Topics: Animals; Bicuculline; Dizocilpine Maleate; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glycine; Hot Temperature; Injections, Spinal; Male; N-Methylaspartate; Nerve Crush; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Strychnine | 1993 |
Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine.
Topics: Animals; Animals, Newborn; Benzoates; Cerebral Cortex; Chromatography, High Pressure Liquid; Cycloleucine; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Motor Neurons; N-Methylaspartate; Phosphatidylinositols; Rats; Spinal Cord; Synapses; Thalamus | 1993 |
NMDA and glycine receptor mRNA expression following transient global ischemia in the gerbil brain.
Topics: Animals; Base Sequence; Brain Ischemia; Gerbillinae; Glycine; Hippocampus; Male; Molecular Sequence Data; N-Methylaspartate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger | 1993 |
Ethanol inhibits NMDA receptor-mediated excitotoxicity in rat primary neuronal cultures.
Topics: Animals; Brain; Cells, Cultured; Ethanol; Female; Glycine; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Degeneration; Neural Inhibition; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1993 |
Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors.
Topics: Action Potentials; Alanine; Animals; Benzoates; CHO Cells; Cricetinae; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; N-Methylaspartate; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses | 1993 |
The dihydropyridine nitrendipine modulates N-methyl-D-aspartate receptor channel function in mammalian neurons.
Topics: Animals; Calcium; Calcium Channels; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Electrophysiology; Glycine; Mice; N-Methylaspartate; Neurons; Nitrendipine; Receptors, N-Methyl-D-Aspartate | 1993 |
A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord.
Topics: Amino Acids; Amino Acids, Dicarboxylic; Animals; Animals, Newborn; Cycloleucine; Cyclopropanes; Electric Stimulation; Electrophysiology; Glycine; In Vitro Techniques; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Reflex, Monosynaptic; Spinal Cord | 1993 |
Alteration of Ca2+ permeability and sensitivity to Mg2+ and channel blockers by a single amino acid substitution in the N-methyl-D-aspartate receptor.
Topics: Amino Acid Sequence; Animals; Calcium; Cell Membrane; Desipramine; Dizocilpine Maleate; Glycine; Macromolecular Substances; Magnesium; Membrane Potentials; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylaspartate; Oocytes; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Restriction Mapping; RNA, Messenger; Sequence Homology, Amino Acid; Xenopus; Zinc | 1993 |
Studies on the effects of several pentamidine analogues on the NMDA receptor.
Topics: Animals; Binding, Competitive; Calcium; Cell Survival; Dizocilpine Maleate; Fura-2; Glycine; In Vitro Techniques; N-Methylaspartate; Neurons; Pentamidine; Prosencephalon; Rats; Receptors, N-Methyl-D-Aspartate | 1993 |
Age-related decrease of the NMDA receptor-mediated noradrenaline release in rat hippocampus and partial restoration by D-cycloserine.
Topics: Aging; Animals; Cycloserine; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred WKY; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Synaptosomes | 1993 |
Effects of pH on the actions of dizocilpine at the N-methyl-D-aspartate receptor complex.
Topics: Animals; Dizocilpine Maleate; Fura-2; Glycine; Hydrogen-Ion Concentration; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence | 1993 |
Characterization of agonist-induced down-regulation of NMDA receptors in cerebellar granule cell cultures.
Topics: Animals; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cerebellum; Down-Regulation; Enzyme Inhibitors; Glycine; Molecular Sequence Data; N-Methylaspartate; Neurons; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Signal Transduction | 1996 |
The inhibitory mGluR agonist, S-4-carboxy-3-hydroxy-phenylglycine selectively attenuates NMDA neurotoxicity and oxygen-glucose deprivation-induced neuronal death.
Topics: Animals; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Culture Media; Cyclic AMP; Excitatory Amino Acid Agonists; Glucose; Glycine; N-Methylaspartate; Neurons; Rats; Receptors, Metabotropic Glutamate | 1995 |
Carbamazepine inhibition of N-methyl-D-aspartate-evoked calcium influx in rat cerebellar granule cells.
Topics: Animals; Anticonvulsants; Calcium; Carbamazepine; Cerebellum; Cytoplasmic Granules; Drug Synergism; Glycine; Intracellular Fluid; N-Methylaspartate; Potassium Chloride; Pregnenolone; Rats | 1996 |
Glutamate receptor agonists modulate [Ca2+]i in isolated rat melanotropes.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Fluorescent Dyes; Fura-2; Glutamic Acid; Glycine; Kainic Acid; Magnesium; Male; N-Methylaspartate; Pituitary Gland; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate | 1995 |
Persistent increase in dopamine release following activation of metabotropic glutamate receptors in the rat nucleus accumbens.
Topics: Animals; Benzoates; Chromatography, High Pressure Liquid; Cycloleucine; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Male; Microdialysis; N-Methylaspartate; Neurotoxins; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1995 |
Ethanol-induced inhibition of [3H]thienylcyclohexylpiperidine (TCP) binding to NMDA receptors in brain synaptic membranes and to a purified protein complex.
Topics: Animals; Brain Chemistry; Dizocilpine Maleate; Dopamine Antagonists; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Haloperidol; Illicit Drugs; Kinetics; Male; Membrane Proteins; N-Methylaspartate; Phencyclidine; Protein Binding; Proteins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sensitivity and Specificity; Spermidine; Synaptic Membranes; Tritium | 1996 |
Opposing effects on blood pressure following the activation of metabotropic and ionotropic glutamate receptors in raphe obscurus in the anaesthetized rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Benzoates; Blood Pressure; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hypertension; Male; Microinjections; N-Methylaspartate; Neurotoxins; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Structure-Activity Relationship; Valine | 1996 |
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors.
Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; Cerebral Cortex; Cricetinae; Cyclic AMP; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Kidney; Kinetics; Mice; N-Methylaspartate; Neuroglia; Neurons; Neurotoxins; Phosphatidylinositols; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 1996 |
DCG-IV selectively attenuates rapidly triggered NMDA-induced neurotoxicity in cortical neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bucladesine; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cyclopropanes; Glycine; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Neurotoxins; Pertussis Toxin; Receptors, Metabotropic Glutamate; Virulence Factors, Bordetella | 1996 |
Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120.
Topics: Adult; Aged; Allosteric Site; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; Gene Products, env; Glycine; HIV Envelope Protein gp120; HIV-1; Humans; Kynurenic Acid; Male; Middle Aged; N-Methylaspartate; Norepinephrine; Peptide Fragments; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1996 |
N-methyl-D-aspartate-stimulated increases in intracellular calcium exhibit brain regional differences in sensitivity to inhibition by ethanol.
Topics: Animals; Animals, Newborn; Brain; Brain Stem; Calcium; Culture Techniques; Dose-Response Relationship, Drug; Ethanol; Glycine; Hippocampus; Intracellular Fluid; N-Methylaspartate; Neurons; Prosencephalon; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1996 |
Physiological and pharmacological profile of trans-azetidine-2,4-dicarboxylic acid: metabotropic glutamate receptor agonism and effects on long-term potentiation.
Topics: Animals; Azetidinecarboxylic Acid; Benzoates; Cells, Cultured; Colforsin; Cyclic AMP; Epithelial Cells; Epithelium; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Hydrolysis; Inositol Phosphates; Kidney; Long-Term Potentiation; Male; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Swine; Temperature; Transfection | 1996 |
L-Glutamate-induced responses in OFF-type bipolar cells of the cat retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Calcium; Cats; Chlorides; Cycloleucine; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; In Vitro Techniques; Ion Transport; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Potassium; Retina; Retinal Cone Photoreceptor Cells; Sodium | 1996 |
The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits.
Topics: Animals; Cerebral Cortex; Female; Glutamic Acid; Glycine; Kainic Acid; Macromolecular Substances; Membrane Potentials; N-Methylaspartate; Nerve Tissue Proteins; Oocytes; Polymerase Chain Reaction; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA, Messenger; Xenopus laevis | 1996 |
Activation of multiple metabotropic glutamate receptor subtypes prevents NMDA-induced excitotoxicity in rat hippocampal slices.
Topics: Animals; Benzoates; Cycloleucine; Excitatory Amino Acid Antagonists; Female; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neuroprotective Agents; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1996 |
Changes in intracellular calcium induced by NMDA in cultured rat hippocampal neurons require exogenous glycine.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cells, Cultured; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Microscopy, Confocal; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate | 1996 |
Endogenous gamma-L-glutamylglutamate is a partial agonist at the N-methyl-D-aspartate receptors in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cells, Cultured; Cerebellum; Dipeptides; Drug Synergism; Glutamates; Glutamic Acid; Glycine; Magnesium; N-Methylaspartate; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1995 |
Use of subunit-specific antisense oligodeoxynucleotides to define developmental changes in the properties of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Base Sequence; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; Gene Expression Regulation, Developmental; Glycine; Kynurenic Acid; Macromolecular Substances; Molecular Sequence Data; N-Methylaspartate; Oligonucleotides, Antisense; Oocytes; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Xenopus laevis | 1996 |
Effect of 1-aminocyclopropanecarboxylic acid on N-methyl-D-aspartate-stimulated [3H]-noradrenaline release in rat hippocampal synaptosomes.
Topics: Adrenergic alpha-Antagonists; Animals; Cyclopropanes; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tritium | 1996 |
Acamprosate (calcium acetylhomotaurinate) enhances the N-methyl-D-aspartate component of excitatory neurotransmission in rat hippocampal CA1 neurons in vitro.
Topics: Acamprosate; Alcohol Deterrents; Animals; Evoked Potentials; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Taurine | 1996 |
Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice.
Topics: Adrenergic Agonists; Animals; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glycine; Hydantoins; Male; Mice; N-Methylaspartate; Pain; Prostaglandin D2; Spinal Cord; Wakefulness | 1996 |
Excitoprotective effect of felbamate in cultured cortical neurons.
Topics: Animals; Anticonvulsants; Binding Sites; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Felbamate; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Phenylcarbamates; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Strychnine | 1995 |
Glutamate receptor-mediated calcium entry in neurons derived from P19 embryonal carcinoma cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Line; Cytosol; Electrophysiology; Embryonal Carcinoma Stem Cells; Excitatory Amino Acid Agonists; Glycine; Immunohistochemistry; Ion Channel Gating; Kainic Acid; Mice; N-Methylaspartate; Neoplastic Stem Cells; Neurons; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1996 |
Serotonin 5-HT2 receptor activation potentiates N-methyl-D-aspartate receptor-mediated ion currents by a protein kinase C-dependent mechanism.
Topics: Animals; Brain; Diglycerides; Enzyme Activation; Evoked Potentials; Female; Glycine; In Vitro Techniques; Magnesium; Membrane Potentials; N-Methylaspartate; Oocytes; Protein Kinase C; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Serotonin; Tetradecanoylphorbol Acetate; Xenopus laevis | 1996 |
Sustained exposure to 1-aminocyclopropanecarboxylic acid, a glycine partial agonist, alters N-methyl-D-aspartate receptor function and subunit composition.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Calcium; Cell Death; Cerebellum; Cyclic GMP; Cytoplasmic Granules; Drug Synergism; Glutamic Acid; Glycine; Macromolecular Substances; Mice; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA; Stimulation, Chemical | 1995 |
Glycine and calcium-dependent effects of lead on N-methyl-D-aspartate receptor function in rat hippocampal neurons.
Topics: Animals; Binding Sites; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Glycine; Hippocampus; Kynurenic Acid; Lead; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Ca(2+)-dependent inactivation of NMDA receptors: fast kinetics and high Ca2+ sensitivity in rat dorsal horn neurons.
Topics: Action Potentials; Animals; Astrocytes; Caffeine; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Glycine; Kinetics; N-Methylaspartate; Neurons; Phosphodiesterase Inhibitors; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1996 |
Differential effects of five glycine site antagonists on NMDA receptor desensitisation.
Topics: Animals; Benzothiadiazines; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Quinolones; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Modulation of NMDA-induced cytosolic calcium levels by ACPC in cultured cerebellar granule cells.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; Cyclopropanes; Dose-Response Relationship, Drug; Glycine; N-Methylaspartate; Rats; Rats, Wistar | 1996 |
G-protein activation by metabotropic glutamate receptors reduces spike frequency adaptation in neocortical neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adult; Alanine; Amino Acids, Dicarboxylic; Animals; Benzoates; Cycloleucine; Enzyme Inhibitors; Frontal Lobe; Glycine; GTP-Binding Proteins; Guanosine Diphosphate; Humans; Isoquinolines; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Protein Kinase Inhibitors; Protein Kinases; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Signal Transduction; Staurosporine; Sulfonamides; Thionucleotides | 1996 |
Copper modulation of NMDA responses in mouse and rat cultured hippocampal neurons.
Topics: Animals; Animals, Newborn; Cells, Cultured; Copper; Embryo, Mammalian; Glutamic Acid; Glycine; Hippocampus; Membrane Potentials; Mice; Mice, Inbred BALB C; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Zinc | 1996 |
Functional expression of a recombinant unitary glutamate receptor from Xenopus, which contains N-methyl-D-aspartate (NMDA) and non-NMDA receptor subunits.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Electric Conductivity; Genetic Complementation Test; Glycine; Ion Channel Gating; Ligands; Macromolecular Substances; Mice; Molecular Sequence Data; N-Methylaspartate; Precipitin Tests; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sequence Alignment; Structure-Activity Relationship; Xenopus laevis | 1996 |
Washable endogenous substances and regional heterogeneity in agonist enhanced [3H]MK-801 binding in rat brain.
Topics: Animals; Autoradiography; Binding Sites; Brain; Dizocilpine Maleate; Glycine; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Spermidine; Temperature; Therapeutic Irrigation; Time Factors; Tissue Distribution; Tritium | 1996 |
Potentiation of the glycine-activated Cl- current by ethanol in cultured mouse spinal neurons.
Topics: Animals; Chloride Channels; Cholera Toxin; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Ethanol; gamma-Aminobutyric Acid; Glycine; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Pertussis Toxin; Protein Kinase Inhibitors; Protein Kinases; Spinal Cord; Virulence Factors, Bordetella | 1996 |
Glycine does not reverse the inhibitory actions of ethanol on NMDA receptor functions in cerebellar granule cells.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Ethanol; Glycine; N-Methylaspartate; Phorbol 12,13-Dibutyrate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Single-channel evidence for glycine and NMDA requirement in NMDA receptor activation.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Glycine; Ion Channels; Membrane Potentials; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate | 1996 |
Coupling of permeation and gating in an NMDA-channel pore mutant.
Topics: Animals; Cesium; Cloning, Molecular; Electric Conductivity; Female; Glycine; Ion Channel Gating; Membrane Potentials; Models, Biological; Mutagenesis, Site-Directed; N-Methylaspartate; Oocytes; Patch-Clamp Techniques; Protein Conformation; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sodium; Xenopus laevis | 1997 |
Acute or prolonged exposure to 1-aminocyclopropanecarboxylic acid protects spinal neurons against NMDA toxicity.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Cells, Cultured; Glycine; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1996 |
Characterization of glutamate toxicity in cultured rat cerebellar granule neurons at reduced temperature.
Topics: Animals; Cell Count; Cells, Cultured; Cerebellum; Cold Temperature; Drug Synergism; Glutamic Acid; Glycine; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
High extracellular glycine does not potentiate N-methyl-D-aspartate-evoked depolarization in vivo.
Topics: Animals; Electroencephalography; Electrophysiology; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; Glycine; Male; Membrane Potentials; Microdialysis; N-Methylaspartate; Neostriatum; Neurons; Neurotoxins; Perfusion; Rats; Rats, Sprague-Dawley | 1997 |
Characterization of metabotropic glutamate receptor-mediated nitric oxide production in vivo.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Biomarkers; Calcium Channels; Citrulline; Cycloleucine; Dantrolene; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Male; Microdialysis; Muscle Proteins; N-Methylaspartate; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Ryanodine Receptor Calcium Release Channel; Tetrodotoxin | 1997 |
The neuroprotective activity of group-II metabotropic glutamate receptors requires new protein synthesis and involves a glial-neuronal signaling.
Topics: Animals; Astrocytes; Cells, Cultured; Cyclopropanes; Glycine; Mice; Mice, Inbred Strains; N-Methylaspartate; Neuroglia; Neuroprotective Agents; Receptors, Metabotropic Glutamate | 1997 |
Competitive antagonism of recombinant AMPA/kainate receptors by N-methyl-D-aspartate and analogues.
Topics: Animals; Benzothiadiazines; Binding, Competitive; Diuretics; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; N-Methylaspartate; Rats; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Sodium Chloride Symporter Inhibitors; Xenopus laevis | 1996 |
4-substituted-3-phenylquinolin-2(1H)-ones: acidic and nonacidic glycine site N-methyl-D-aspartate antagonists with in vivo activity.
Topics: Aminoquinolines; Animals; Anticonvulsants; Binding Sites; Binding, Competitive; Brain; Excitatory Amino Acid Antagonists; Glycine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Mice, Inbred DBA; Molecular Structure; N-Methylaspartate; Quinolones; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1997 |
Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site.
Topics: Animals; Binding Sites; Binding, Competitive; Carboxylic Acids; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Indoles; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; N-Methylaspartate; Rats; Receptors, Glutamate; Structure-Activity Relationship; Strychnine | 1997 |
Effect of glutamate receptor phosphorylation by endogenous protein kinases on electrical activity of isolated postsynaptic densities of rat cortex and hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; Animals; Calcium; Calmodulin; Cerebral Cortex; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Kainic Acid; Long-Term Potentiation; Magnesium; N-Methylaspartate; Patch-Clamp Techniques; Phosphorylation; Protein Kinases; Quisqualic Acid; Rats; Receptors, Glutamate; Synapses | 1997 |
Distribution and projection of the medullary cardiovascular control neurons containing glutamate, glutamic acid decarboxylase, tyrosine hydroxylase and phenylethanolamine N-methyltransferase in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Axonal Transport; Blood Pressure; Cardiovascular System; Electric Stimulation; Glutamate Decarboxylase; Glutamic Acid; Glycine; Heart Rate; Male; Medulla Oblongata; Microelectrodes; N-Methylaspartate; Neurons; Phenylethanolamine N-Methyltransferase; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate | 1997 |
DCG-IV, a potent metabotropic glutamate receptor agonist, as an NMDA receptor agonist in the rat cortical slice.
Topics: Animals; Cyclopropanes; Differential Threshold; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Agonists; Frontal Lobe; Glycine; Male; N-Methylaspartate; Osmolar Concentration; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1997 |
Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Animals, Newborn; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamates; Glycine; N-Methylaspartate; Rats; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Spinal Cord | 1996 |
Nitric oxide regulates NMDA-driven GABAergic inputs to type I neurones of the rat paraventricular nucleus.
Topics: Animals; Bicuculline; Enzyme Inhibitors; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; Membrane Potentials; N-Methylaspartate; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tetrazoles | 1997 |
Enhancement of NMDA responses by group I metabotropic glutamate receptor activation in striatal neurones.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Agents; Glycine; Male; N-Methylaspartate; Neostriatum; Neurons; Patch-Clamp Techniques; Protein Kinase C; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols | 1997 |
Characterization of NMDA- and AMPA-induced enhancement of AP-1 DNA binding activity in rat cerebellar granule cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Cells, Cultured; Cerebellum; Dizocilpine Maleate; DNA-Binding Proteins; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Kinetics; N-Methylaspartate; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Transcription Factor AP-1 | 1997 |
(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.
Topics: Animals; Calcium; CHO Cells; Cricetinae; Excitatory Amino Acid Agonists; Glycine; Hippocampus; In Vitro Techniques; N-Methylaspartate; Phenylacetates; Rats; Receptors, Metabotropic Glutamate | 1997 |
Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; Animals; Cells, Cultured; Cerebral Cortex; Child; Dizocilpine Maleate; Embryo, Mammalian; Evoked Potentials; Glycine; Homocysteine; Humans; Kinetics; Kynurenic Acid; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Responses of Bergmann glia and granule neurons in situ to N-methyl-D-aspartate, norepinephrine, and high potassium.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Agonists; Animals; Benzoates; Calcium; Cerebellum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Fluorescent Dyes; Glycine; N-Methylaspartate; Neuroglia; Neurons; Norepinephrine; Organic Chemicals; Potassium; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 1997 |
Bipotent progenitor cell lines from the human CNS.
Topics: Astrocytes; Brain; Brain-Derived Neurotrophic Factor; Bucladesine; Cell Culture Techniques; Cell Differentiation; Cell Line; Cell Line, Transformed; Fetus; gamma-Aminobutyric Acid; Genes, myc; Gestational Age; Glycine; Humans; Kainic Acid; Membrane Potentials; Models, Neurological; N-Methylaspartate; Neurons; Oncogene Protein p55(v-myc); Recombinant Proteins; Stem Cells; Transfection | 1997 |
Involvement of NMDA in a plasticity phenomenon observed in the adult frog monocular optokinetic nystagmus.
Topics: Animals; Dark Adaptation; Glycine; N-Methylaspartate; Neuronal Plasticity; Nystagmus, Optokinetic; Photic Stimulation; Rana esculenta; Sensory Deprivation; Superior Colliculi; Tetrazoles; Time Factors; Vision, Monocular | 1997 |
Changes in extracellular nitrite and nitrate levels after inhibition of glial metabolism with fluorocitrate.
Topics: Aconitate Hydratase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Benzoates; Cerebellum; Citrates; Citric Acid Cycle; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glycine; Male; N-Methylaspartate; Neuroglia; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Nitroarginine; Quinoxalines; Rats; Rats, Wistar; Substrate Specificity | 1997 |
NMDA receptor coagonist glycine site: evidence for a role in lateral hypothalamic stimulation of feeding.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Eating; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hypothalamic Area, Lateral; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Potentiation of NMDA and AMPA responses by group I mGluR in spinal cord motoneurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Drug Synergism; Excitatory Amino Acid Agonists; Glycine; In Vitro Techniques; Male; Membrane Potentials; Motor Neurons; N-Methylaspartate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord | 1997 |
Characterization of a novel putative cognition enhancer mediating facilitation of glycine effect on strychnine-resistant sites coupled to NMDA receptor complex.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Nootropic Agents; Norepinephrine; Pentanoic Acids; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Spermine; Stereoisomerism | 1997 |
Gp120 can revert antagonism at the glycine site of NMDA receptors mediating GABA release from cultured hippocampal neurons.
Topics: Animals; Binding Sites; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; gamma-Aminobutyric Acid; Glycine; Hippocampus; HIV Envelope Protein gp120; HIV-1; Kynurenic Acid; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 1997 |
Ethanol specifically inhibits NMDA receptors with affinity for ifenprodil in the low micromolar range in cultured cerebellar granule cells.
Topics: Animals; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Glycine; Kinetics; N-Methylaspartate; Neurons; Piperidines; Potassium Chloride; Rats; Receptors, N-Methyl-D-Aspartate | 1997 |
Neurotrophin modulation of NMDA receptors in cultured murine and isolated rat neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain-Derived Neurotrophic Factor; Calcium; Cells, Cultured; Corpus Striatum; Dynorphins; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Ion Channel Gating; Kynurenic Acid; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Nerve Growth Factors; Neurons; Neurotrophin 3; Protein Kinase Inhibitors; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1997 |
Effects of acute and chronic ethanol exposure on heteromeric N-methyl-D-aspartate receptors expressed in HEK 293 cells.
Topics: Animals; Calcium; Cell Line; Drug Combinations; Electric Conductivity; Ethanol; Excitatory Amino Acid Antagonists; Glycine; Humans; Intracellular Membranes; N-Methylaspartate; Oocytes; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Time Factors; Transfection | 1997 |
GV 150526A, 7-Cl-kynurenic acid and HA 966 antagonize the glycine enhancement of N-methyl-D-aspartate-induced [3H]noradrenaline and [3H]dopamine release.
Topics: Animals; Dopamine; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Indoles; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Norepinephrine; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Synaptosomes | 1997 |
Crossed rhythmic synaptic input to motoneurons during selective activation of the contralateral spinal locomotor network.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicuculline; Chlorides; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Glycine; Glycine Agents; Locomotion; Motor Neurons; N-Methylaspartate; Neural Inhibition; Periodicity; Rats; Rats, Wistar; Receptors, GABA-A; Serotonin; Spinal Cord; Spinal Nerve Roots; Strychnine; Synaptic Transmission | 1997 |
A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion.
Topics: Analysis of Variance; Animals; Cerebral Arterial Diseases; Cerebral Cortex; Cerebral Infarction; Coloring Agents; Cortical Spreading Depression; Electroencephalography; Glycine; Infusions, Intravenous; Injections, Intravenous; Ischemic Attack, Transient; Linear Models; Male; N-Methylaspartate; Neuroprotective Agents; Placebos; Pyridazines; Quinolines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Single-Blind Method; Tetrazolium Salts | 1998 |
Modulation of neuronal mitochondrial membrane potential by the NMDA receptor: role of arachidonic acid.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Local; Animals; Arachidonic Acid; Biomarkers; Cells, Cultured; Cerebellum; Dibucaine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flow Cytometry; Fluorescent Dyes; Glycine; Intracellular Membranes; Kynurenic Acid; Membrane Potentials; Mitochondria; N-Methylaspartate; Piperidines; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rhodamine 123; Rhodamines; Sulfonamides | 1997 |
Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzoates; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Kinetics; Motor Neurons; N-Methylaspartate; Neuroprotective Agents; Rats; Spinal Cord | 1997 |
2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity.
Topics: Animals; Avoidance Learning; Binding Sites; Cyclic N-Oxides; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Mice; Motor Activity; N-Methylaspartate; Neuroprotective Agents; Pyrazines; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Stereotyped Behavior; Strychnine | 1997 |
Glycine increases arterial pressure and augments NMDA-induced pressor responses in the dorsomedial and ventrolateral medulla of cats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Cats; Dorsomedial Hypothalamic Nucleus; Drug Synergism; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Glycine; Kynurenic Acid; Male; Microinjections; N-Methylaspartate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Ventromedial Hypothalamic Nucleus | 1997 |
Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors.
Topics: Animals; Calcium; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Humans; Kidney; Kynurenic Acid; Membrane Potentials; Molecular Sequence Data; N-Methylaspartate; Oocytes; Patch-Clamp Techniques; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Xenopus laevis | 1998 |
Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Bicuculline; Calcium; Cells, Cultured; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dizocilpine Maleate; Fetus; Glycine; Humans; Mice; N-Methylaspartate; Neocortex; Neurites; Neurons; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Steroid 17-alpha-Hydroxylase | 1998 |
Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia.
Topics: Animals; Cell Count; Chromatography, High Pressure Liquid; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Intraocular Pressure; Ischemia; Male; Memantine; N-Methylaspartate; Ocular Hypertension; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Retinal Vessels; Vitreous Body | 1998 |
Substance P modulates NMDA responses and causes long-term protein synthesis-dependent modulation of the lamprey locomotor network.
Topics: Animals; Dopamine D2 Receptor Antagonists; Electrophysiology; Glycine; Lampreys; Magnesium; Motor Activity; N-Methylaspartate; Nerve Net; Nerve Tissue Proteins; Protein Kinase C; Protein Synthesis Inhibitors; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems; Substance P; Tachykinins; Time Factors | 1998 |
Release and accumulation of neurotransmitters in the rat brain: acute effects of ethanol in vitro and effects of long-term voluntary ethanol intake.
Topics: Acetylcholine; Alcoholism; Animals; Brain; Caudate Nucleus; Ethanol; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Male; Morphine; N-Methylaspartate; Neurotransmitter Agents; Putamen; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1998 |
Characterization of desensitization in recombinant N-methyl-D-aspartate receptors: comparison with native receptors in cultured hippocampal neurons.
Topics: Allosteric Site; Animals; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Humans; Ion Channel Gating; Kidney; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins | 1998 |
Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel metabotropic glutamate receptor-1-selective antagonist S-2-methyl-4-carboxy-phenylglycine.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoates; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Male; N-Methylaspartate; Naphthols; Neurons, Afferent; Neuroprotective Agents; Propylene Glycols; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Thalamus | 1998 |
Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; Cyclopropanes; Dipeptides; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Glycine; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Receptors, Metabotropic Glutamate | 1998 |
Inhibition of NMDA-gated ion channels by the P2 purinoceptor antagonists suramin and reactive blue 2 in mouse hippocampal neurones.
Topics: Animals; Cells, Cultured; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Ion Channels; Mice; N-Methylaspartate; Neurons, Afferent; Patch-Clamp Techniques; Protein Synthesis Inhibitors; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Suramin; Triazines | 1998 |
Metabotropic glutamate receptor activation modulates sound level processing in the cochlear nucleus.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Auditory Pathways; Auditory Perception; Benzoates; Cats; Cochlear Nucleus; Cycloleucine; Evoked Potentials; Excitatory Amino Acid Antagonists; Gerbillinae; Glycine; N-Methylaspartate; Neurons; Neuroprotective Agents; Receptors, Metabotropic Glutamate; Time Factors | 1998 |
Screening of receptor antagonists using agonist-activated patch clamp detection in chemical separations.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding, Competitive; Electrophoresis, Capillary; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Ion Channels; Mathematics; N-Methylaspartate; Neurons; Olfactory Bulb; Patch-Clamp Techniques; Quinoxalines; Rats; Receptors, Cell Surface | 1998 |
Selective modulation of GABAA receptors by aluminum.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aluminum; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; N-Methylaspartate; Neurons, Afferent; Olfactory Bulb; Patch-Clamp Techniques; Rats; Receptors, GABA-A; Receptors, Glutamate; Smell | 1998 |
Chronic dosing with 1-aminocyclopropanecarboxylic acid, a glycine partial agonist, modulates NMDA inhibition of muscarinic-coupled PI hydrolysis in rat cortical slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Carbachol; Cerebral Cortex; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hydrolysis; In Vitro Techniques; Inositol; Kynurenic Acid; Male; Muscarinic Agonists; N-Methylaspartate; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
Multiple sites of action of neomycin, Mg2+ and spermine on the NMDA receptors of rat hippocampal CA1 pyramidal neurones.
Topics: Animals; Binding Sites; Calcium; Cell Line; Cells, Cultured; Evoked Potentials; Glutamic Acid; Glycine; Hippocampus; Humans; Magnesium; N-Methylaspartate; Neomycin; Pyramidal Cells; Rats; Receptors, N-Methyl-D-Aspartate; Spermine; Transfection | 1998 |
Antagonists for group I mGluRs attenuate excitotoxic neuronal death in cortical cultures.
Topics: Animals; Astrocytes; Benzoates; Cell Death; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Indans; Mice; N-Methylaspartate; Neurons; Neurotransmitter Agents; Protein Binding; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1998 |
Evidence for functional native NMDA receptors activated by glycine or D-serine alone in the absence of glutamatergic coagonist.
Topics: Animals; Cerebral Cortex; Cholecystokinin; Dose-Response Relationship, Drug; Drug Synergism; Glutamic Acid; Glycine; Male; N-Methylaspartate; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Somatostatin; Stereoisomerism; Synaptosomes | 1998 |
Spinal inputs from lateral columns to reticulospinal neurons in lampreys.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Brain Stem; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Aminobutyric Acid; Glycine; Isotonic Solutions; Lampreys; Locomotion; Magnesium; N-Methylaspartate; Neural Inhibition; Neural Pathways; Neurotransmitter Agents; Ringer's Solution; Spinal Cord; Synaptic Transmission | 1998 |
Regulation of intrinsic and synaptic properties of neonatal rat trigeminal motoneurons by metabotropic glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzoates; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neuroprotective Agents; Patch-Clamp Techniques; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission; Tetrodotoxin; Trigeminal Nuclei | 1998 |
Amyloid beta-protein impairs astrocyte-mediated differentiation of hippocampal neurons.
Topics: Amyloid beta-Peptides; Animals; Astrocytes; Calcium Signaling; Cell Differentiation; Cell Membrane; Cells, Cultured; Coculture Techniques; Electric Conductivity; Embryo, Mammalian; Fetus; gamma-Aminobutyric Acid; Glycine; Hippocampus; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Peptide Fragments; Rats; Time Factors | 1998 |
Endogenous activation of metabotropic glutamate receptors contributes to burst frequency regulation in the lamprey locomotor network.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Lampreys; Locomotion; Membrane Potentials; N-Methylaspartate; Nerve Net; Periodicity; Propionates; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord; Synaptic Transmission | 1998 |
D-serine and the therapeutic challenge posed by the N-methyl-D-aspartate antagonist model of schizophrenia.
Topics: Glycine; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine | 1998 |
Carnosine modulates zinc and copper effects on amino acid receptors and synaptic transmission.
Topics: Action Potentials; Animals; Brain Chemistry; Carnosine; Cells, Cultured; Copper; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; N-Methylaspartate; Neurons; Olfactory Bulb; Patch-Clamp Techniques; Rats; Receptors, Amino Acid; Receptors, GABA; Receptors, Glutamate; Receptors, Glycine; Synaptic Transmission; Zinc | 1998 |
Taurine, glutamate and GABA modulate the outgrowth from goldfish retinal explants and its concentrations are affected by the crush of the optic nerve.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Culture Techniques; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Goldfish; N-Methylaspartate; Neurites; Optic Nerve; Retina; Taurine | 1998 |
Excitotoxic death of a subset of embryonic rat motor neurons in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Calcium Channels, L-Type; Cell Culture Techniques; Cell Death; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glutamine; Glycine; Kainic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Nerve Tissue Proteins; Neurotoxins; Potassium; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
NMDA receptor characterization and subunit expression in rat cultured mesencephalic neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Gene Expression; Gene Expression Regulation, Developmental; Glycine; Memantine; Mesencephalon; N-Methylaspartate; Neurons; Nitrendipine; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA Splicing; RNA, Messenger | 1999 |
Mechanisms involved in the metabotropic glutamate receptor-enhancement of NMDA-mediated motoneurone responses in frog spinal cord.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Benzoates; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Chlorpromazine; Cycloleucine; Dose-Response Relationship, Drug; Drug Synergism; Egtazic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; GTP-Binding Proteins; In Vitro Techniques; Kynurenic Acid; Magnesium; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neuroprotective Agents; Pertussis Toxin; Rana pipiens; Receptors, Metabotropic Glutamate; Reflex; Resorcinols; Second Messenger Systems; Spinal Cord; Sulfonamides; Tetrodotoxin; Thapsigargin; Virulence Factors, Bordetella | 1999 |
Excitatory amino acid responses in relay neurons of the rat lateral geniculate nucleus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antihypertensive Agents; Benzothiadiazines; Concanavalin A; Dipeptides; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Geniculate Bodies; Glutamic Acid; Glycine; Ionophores; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neuroprotective Agents; Nystatin; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1999 |
Long-term suppression of synaptic transmission by tetanization of a single pyramidal cell in the mouse hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Benzoates; Bicuculline; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Glycine; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Phosphinic Acids; Propanolamines; Pyramidal Cells; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1999 |
Intracellular polyamine levels are involved in NMDA-evoked nitric oxide production in chick retina cells.
Topics: Animals; Arginine; Cells, Cultured; Chick Embryo; Citrulline; Cyclic GMP; Eflornithine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glycine; N-Methylaspartate; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase; Polyamines; Receptors, N-Methyl-D-Aspartate; Retina; Spermidine | 1999 |
Properties of NMDA receptors in rat spinal cord motoneurons.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Ion Channel Gating; Kainic Acid; Kynurenic Acid; Magnesium; Male; Motor Neurons; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
NMDA receptor-mediated calcium influx in cerebral cortical synaptosomes of the hypoxic guinea pig fetus.
Topics: Animals; Calcium; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Fetal Hypoxia; Glutamic Acid; Glycine; Guinea Pigs; N-Methylaspartate; Potassium Chloride; Pregnancy; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Thapsigargin | 1999 |
Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 recept
Topics: Animals; Astrocytes; Benzoates; Caudate Nucleus; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; Fetus; Gerbillinae; Glycine; Ischemic Attack, Transient; Male; Mice; N-Methylaspartate; Necrosis; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Thiophenes | 1999 |
[3H]CGP 61594, the first photoaffinity ligand for the glycine site of NMDA receptors.
Topics: Affinity Labels; Animals; Azides; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Cerebral Cortex; Electrophysiology; Evoked Potentials; Excitatory Amino Acid Agonists; Glycine; Hippocampus; In Vitro Techniques; Kinetics; Ligands; Male; N-Methylaspartate; Neocortex; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Tritium | 1999 |
Cardiovascular response to group I metabotropic glutamate receptor activation in NTS.
Topics: Animals; Baroreflex; Benzoates; Blood Pressure; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Kynurenic Acid; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sympathetic Nervous System | 1999 |
Protection by eliprodil against excitotoxicity in cultured rat retinal ganglion cells.
Topics: Animals; Cell Death; Cells, Cultured; Drug Combinations; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Male; N-Methylaspartate; Neuroprotective Agents; Piperidines; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells | 1999 |
Factors that enhance ethanol inhibition of N-methyl-D-aspartate receptors in cerebellar granule cells.
Topics: Animals; Animals, Newborn; Cell Line; Cells, Cultured; Cerebellum; Drug Synergism; Ethanol; Excitatory Amino Acid Antagonists; Glycine; Humans; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Time Factors; Transfection | 1999 |
(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo.
Topics: Animals; Anticonvulsants; Brain; Cell Line; Cell Membrane; Colforsin; Corpus Striatum; Cyclic AMP; Electroshock; Glutamic Acid; Glycine; Humans; Kinetics; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Neuroprotective Agents; Phosphatidylinositols; Protein Isoforms; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Recombinant Proteins; Second Messenger Systems; Seizures; Structure-Activity Relationship | 1999 |
Metabotropic glutamate receptor modulation of excitotoxicity in the neostriatum: role of calcium channels.
Topics: Animals; Barium; Brain Edema; Cadmium; Calcium Channel Blockers; Calcium Channels; Cycloleucine; Excitatory Amino Acid Agonists; Glycine; Membrane Potentials; Methoxyhydroxyphenylglycol; Microscopy, Video; N-Methylaspartate; Neostriatum; Neuroprotective Agents; Neurotoxins; omega-Conotoxin GVIA; Organ Culture Techniques; Patch-Clamp Techniques; Peptides; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1999 |
Pituitary adenylate cyclase activating peptide phase shifts circadian rhythms in a manner similar to light.
Topics: Animals; Circadian Rhythm; Cricetinae; Dose-Response Relationship, Drug; Drug Combinations; Electrophysiology; Glycine; Light; Male; Mesocricetus; N-Methylaspartate; Neurons; Neuropeptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, N-Methyl-D-Aspartate; Suprachiasmatic Nucleus | 1999 |
Subpopulations of GABAergic and non-GABAergic rat dorsal horn neurons express Ca2+-permeable AMPA receptors.
Topics: Aging; Animals; Calcium; Calcium-Binding Proteins; Cobalt; gamma-Aminobutyric Acid; Glycine; Immunohistochemistry; N-Methylaspartate; Neurons; Neurotoxins; Permeability; Rats; Receptors, AMPA; Receptors, Neurokinin-1; Spinal Cord; Tyrosine 3-Monooxygenase | 1999 |
N-methyl-D-aspartate receptor agonists modulate homocysteine-induced developmental abnormalities.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chick Embryo; Cycloserine; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Homocysteine; N-Methylaspartate; Nervous System; Nervous System Malformations; Receptors, N-Methyl-D-Aspartate; Teratogens | 1999 |
Toxicity induced by a polyglutamated folate analog is attenuated by NAALADase inhibition.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Carboxypeptidases; Cells, Cultured; Cerebral Cortex; Deoxyglucose; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fetus; Glutamate Carboxypeptidase II; Glycine; Methotrexate; N-Methylaspartate; Neurons; Neurotoxins; Organophosphorus Compounds; Potassium Cyanide; Pyrrolidines; Rats | 1999 |
Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurons.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzophenanthridines; Calcium; Cycloleucine; Drug Synergism; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Membrane Potentials; Motor Neurons; N-Methylaspartate; Phenanthridines; Phenylacetates; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Spinal Cord | 1999 |
Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient mice.
Topics: Animals; Astrocytes; Carrier Proteins; Cells, Cultured; Culture Media, Conditioned; Dendrites; Glycine; Hippocampus; Membrane Potentials; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; SAP90-PSD95 Associated Proteins; Spinal Cord; Synapses | 1999 |
N-methyl-D-aspartate receptor binding is altered and seizure potential reduced in pregnant rats.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Convulsants; Dizocilpine Maleate; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Hippocampus; Male; N-Methylaspartate; Pregnancy; Pregnancy, Animal; Radioligand Assay; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Tritium | 1999 |
Regulation of NMDA-stimulated [14C]GABA and [3H]acetylcholine release by striatal glutamate and dopamine receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoates; Carbon Radioisotopes; Corpus Striatum; Cycloleucine; Dopamine Agonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; Male; N-Methylaspartate; Proline; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tritium | 1999 |
Physiological evidence for ionotropic and metabotropic glutamate receptors in rat taste cells.
Topics: 2-Amino-5-phosphonovalerate; 8-Bromo Cyclic Adenosine Monophosphate; Aminobutyrates; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Male; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Taste Buds | 1999 |
Putative partial agonist 1-aminocyclopropanecarboxylic acid acts concurrently as a glycine-site agonist and a glutamate-site antagonist at N-methyl-D-aspartate receptors.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Binding Sites; Cerebellum; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate | 1999 |
Effects of inhibitory neurotransmitters on the mudpuppy (Necturus maculatus) locomotor pattern in vitro.
Topics: Animals; Baclofen; Bicuculline; Electromyography; Excitatory Amino Acid Agonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Locomotion; Membrane Potentials; N-Methylaspartate; Necturus; Neural Inhibition; Organophosphorus Compounds; Receptors, GABA-A; Receptors, GABA-B; Spinal Cord | 1999 |
Interleukin-1 inhibits NMDA-stimulated GnRH secretion: associated effects on the release of hypothalamic inhibitory amino acid neurotransmitters.
Topics: Animals; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glycine; Gonadotropin-Releasing Hormone; Hypothalamus, Middle; Interleukin-1; Male; N-Methylaspartate; Neural Inhibition; Neuroimmunomodulation; Preoptic Area; Rats; Rats, Wistar; Taurine | 2000 |
Inhibition of NMDA-induced currents by conantokin-G and conantokin-T in cultured embryonic murine hippocampal neurons.
Topics: Animals; Cells, Cultured; Conotoxins; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mollusk Venoms; N-Methylaspartate; Neurons; Peptides; Receptors, N-Methyl-D-Aspartate; Spermine | 1999 |
Bilobalide, a constituent of Ginkgo biloba, inhibits NMDA-induced phospholipase A2 activation and phospholipid breakdown in rat hippocampus.
Topics: Animals; Cells, Cultured; Choline; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; Furans; Ginkgo biloba; Ginkgolides; Glycerylphosphorylcholine; Glycine; Hippocampus; Lysophosphatidylcholines; Male; Microdialysis; N-Methylaspartate; Phospholipases A; Phospholipases A2; Phospholipids; Plants, Medicinal; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 1999 |
Regulation by glycine, Mg2+ and polyamines of the N-methyl-D-aspartate-induced locomotion in the neonatal rat spinal cord in vitro.
Topics: Animals; Biguanides; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Kynurenic Acid; Magnesium; Motor Activity; Motor Neurons; N-Methylaspartate; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Spinal Cord; Synapses | 1999 |
[The ameliorating effects of a novel NC-1900 on impairments of learning/memory caused by glutamic acid].
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arginine Vasopressin; Avoidance Learning; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Kainic Acid; Learning Disabilities; Male; Memory Disorders; Mice; Mice, Inbred Strains; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oligopeptides; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Resorcinols | 1999 |
Glutamate and GABA activate different receptors and Cl(-) conductances in crab peptide-secretory neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Brachyura; Cells, Cultured; Chloride Channels; Chlorides; Concanavalin A; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Quisqualic Acid; Receptors, AMPA; Receptors, GABA; Receptors, Glutamate | 2000 |
Neuroprotective actions of novel and potent ligands of group I and group II metabotropic glutamate receptors.
Topics: Animals; Benzoates; Bridged Bicyclo Compounds; Cells, Cultured; Cerebral Cortex; Drug Evaluation, Preclinical; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gerbillinae; Glycine; Ischemia; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Thiophenes | 1999 |
Glycine induced calcium concentration changes in vestibular type I sensory cells.
Topics: Animals; Calcium; Chelating Agents; Chlorides; Egtazic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Glycine; Guinea Pigs; Hair Cells, Vestibular; Kynurenic Acid; Models, Neurological; N-Methylaspartate; Strychnine | 2000 |
Neuroprotection by metabotropic glutamate receptor agonists on kainate-induced degeneration of motor neurons in spinal cord slices from adult rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Cell Survival; Choline O-Acetyltransferase; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; In Situ Nick-End Labeling; In Vitro Techniques; Kainic Acid; Male; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord | 2000 |
Behavioural effects of glutamate receptor agonists in morphine-dependent rats.
Topics: Animals; Behavior, Animal; Brain Chemistry; Discrimination, Psychological; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Isosorbide Dinitrate; Kainic Acid; Male; Morphine Dependence; N-Methylaspartate; Naloxone; Narcotic Antagonists; Nitric Oxide Donors; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
N-methyl-D-aspartate enhancement of the glycine response in the rat sacral dorsal commissural neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Chloride Channels; Drug Synergism; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Kinetics; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Spinal Cord | 2000 |
Inhibition of striatal dopamine release by glycine and glycyldodecylamide.
Topics: Aminoquinolines; Animals; Corpus Striatum; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Mice; N-Methylaspartate; Neurons; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Subcellular Fractions; Tritium | 2000 |
Enhancement of NMDA-induced current by the putative NR2B selective antagonist ifenprodil.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 2000 |
In CA1 pyramidal neurons of the hippocampus protein kinase C regulates calcium-dependent inactivation of NMDA receptors.
Topics: Animals; Calcium; Calmodulin; Egtazic Acid; Enzyme Activation; Evoked Potentials; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Glycine; Hippocampus; In Vitro Techniques; Kinetics; N-Methylaspartate; Protein Kinase C; Protein-Tyrosine Kinases; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tetradecanoylphorbol Acetate | 2000 |
Potentiation of NMDA receptor function by the serine protease thrombin.
Topics: Animals; Glycine; Hippocampus; In Vitro Techniques; Mice; Mice, Knockout; N-Methylaspartate; Peptide Fragments; Pyramidal Cells; Rats; Receptor, PAR-1; Receptors, N-Methyl-D-Aspartate; Receptors, Thrombin; Thrombin | 2000 |
The regulatory connection between the activity of granule cell NMDA receptors and dendritic differentiation of cerebellar Purkinje cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Calcium; Cell Count; Cell Differentiation; Cells, Cultured; Dendrites; Excitatory Amino Acid Antagonists; Glycine; Intracellular Fluid; N-Methylaspartate; Nitric Oxide; Purkinje Cells; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synaptic Transmission | 2000 |
Alcohols inhibit N-methyl-D-aspartate receptors via a site exposed to the extracellular environment.
Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Electrophysiology; Ethanol; Extracellular Space; Glycine; Green Fluorescent Proteins; Luminescent Proteins; Membrane Potentials; Mutation; N-Methylaspartate; Pentanols; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Transfection | 2000 |
Modification of the Xenopus electroretinogram by actions of glycine in the proximal retina.
Topics: Aminobutyrates; Animals; Dose-Response Relationship, Drug; Electroretinography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Photic Stimulation; Pipecolic Acids; Retina; Strychnine; Xenopus laevis | 2000 |
Re: Mazarati et al. "...clinically available [antiepileptic drug] with a moderate affinity for the glycine site of the N-methyl-D-aspartate (NMDA) receptor".
Topics: Anticonvulsants; Epilepsy; Felbamate; Glycine; Humans; N-Methylaspartate; Phenylcarbamates; Propylene Glycols; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 2000 |
Effects of RPR 118723, a novel antagonist at the glycine site of the NMDA receptor, in vitro.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Male; Membranes; Mice; N-Methylaspartate; Phencyclidine; Pyrazines; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Tritium | 2000 |
Motor stimulation following bilateral injection of the group-I metabotropic glutamate receptor agonist into the dorsal striatum of rats: evidence against dependence on ionotropic glutamate receptors.
Topics: Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Male; Microinjections; Motor Activity; N-Methylaspartate; Neostriatum; Neurons; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Stimulation, Chemical | 2000 |
Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death.
Topics: Aminobutyrates; Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Heterozygote; Mice; Mice, Knockout; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Receptors, Metabotropic Glutamate; Stereoisomerism | 2000 |
Fetal alcohol exposure alters neurosteroid modulation of hippocampal N-methyl-D-aspartate receptors.
Topics: Animals; Cells, Cultured; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Glycine; Hippocampus; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pregnancy; Pregnenolone; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 2000 |
N-methyl-D-aspartate but not glutamate induces the release of hydroxyl radicals in the neonatal rat: modulation by group I metabotropic glutamate receptors.
Topics: Animals; Animals, Newborn; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hydroxybenzoates; Hydroxyl Radical; Hypoxia-Ischemia, Brain; Ibotenic Acid; Indans; Microdialysis; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols | 2000 |
Age-related decline in the functional response of striatal group I mGlu receptors.
Topics: Aging; Animals; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Hydrolysis; Male; Microdialysis; N-Methylaspartate; Neostriatum; Neurons; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols | 2000 |
Transient expression of NMDA receptor subunit NR2B in the developing rat heart.
Topics: Animals; Antibodies; Antibody Specificity; Blotting, Western; Cells, Cultured; Glycine; Heart; Immunohistochemistry; Membrane Potentials; Myocardium; N-Methylaspartate; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 2000 |
Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism.
Topics: Animals; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Fetus; Glutamic Acid; Glycine; Hydrolysis; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phenylacetates; Phosphatidylinositols; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2000 |
Role of Ca2+ stores in metabotropic L-glutamate receptor-mediated supralinear Ca2+ signaling in rat hippocampal neurons.
Topics: Action Potentials; Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Cells, Cultured; Contraindications; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Space; Glycine; Hippocampus; N-Methylaspartate; Neuroglia; Neurons; Patch-Clamp Techniques; Potassium; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols | 2000 |
N-methyl-D-aspartate receptors mediating hippocampal noradrenaline and striatal dopamine release display differential sensitivity to quinolinic acid, the HIV-1 envelope protein gp120, external pH and protein kinase C inhibition.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; HIV Envelope Protein gp120; Hydrogen-Ion Concentration; Male; N-Methylaspartate; Norepinephrine; Piperidines; Protein Kinase C; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Synaptosomes; Zinc | 2001 |
Three pairs of cysteine residues mediate both redox and zn2+ modulation of the nmda receptor.
Topics: Animals; Binding Sites; Cells, Cultured; Cysteine; Dithiothreitol; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Histidine; Mesylates; Mutagenesis, Site-Directed; N-Methylaspartate; Oocytes; Oxidation-Reduction; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Sulfhydryl Reagents; Transfection; Xenopus; Zinc | 2001 |
NMDA-responsible, APV-insensitive receptor in cultured human astrocytes.
Topics: Astrocytes; Calcium; Cells, Cultured; Glial Fibrillary Acidic Protein; Glycine; GTP-Binding Proteins; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Valine | 2001 |
NMDA and glycine regulate the affinity of the Mg2+-block site in NR1-1a/NR2A NMDA receptor channels expressed in Xenopus oocytes.
Topics: Animals; Calcium; Glycine; Hydrogen-Ion Concentration; Ion Channels; Magnesium; Membrane Potentials; N-Methylaspartate; Oocytes; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Xenopus laevis | 2001 |
Glutamate does not play a major role in controlling bone growth.
Topics: 2-Amino-5-phosphonovalerate; Alveolar Bone Loss; Amino Acid Transport System X-AG; Animals; Animals, Newborn; ATP-Binding Cassette Transporters; Biological Transport; Bone Diseases, Metabolic; Bone Remodeling; Bone Resorption; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Femur; Glutamic Acid; Glycine; Humerus; Mandible; Mice; Mice, Knockout; Models, Animal; N-Methylaspartate; Osteoblasts; Osteoclasts; Osteogenesis; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2001 |
An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Enzyme Activation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Mice; N-Methylaspartate; Nerve Degeneration; Neural Inhibition; Neuroprotective Agents; Neurotoxins; Protein Kinase C; Quisqualic Acid; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Time Factors | 2001 |
Synthesis of tricyclic indole-2-carboxylic [correction of caboxylic] acids as potent NMDA-glycine antagonists.
Topics: Animals; Binding Sites; Carboxylic Acids; Glycine; Glycine Agents; Heterocyclic Compounds, 3-Ring; Humans; Indoles; N-Methylaspartate; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Structure-Activity Relationship | 2001 |
Electrophysiological characterization of "giant" cells in stratum radiatum of the CA3 hippocampal region.
Topics: 2-Amino-5-phosphonovalerate; 3,3'-Diaminobenzidine; Action Potentials; Animals; Axons; Bicuculline; Calcium; Cesium; Chlorides; Choline; Cyclopropanes; Dendrites; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Immunoenzyme Techniques; Microscopy, Video; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Propanolamines; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 2001 |
Structure-activity relationships of 1,4-dihydro-(1H,4H)-quinoxaline-2,3-diones as N-methyl-D-aspartate (glycine site) receptor antagonists. 1. Heterocyclic substituted 5-alkyl derivatives.
Topics: Aminoquinolines; Animals; Cell Membrane; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glycine; Indicators and Reagents; Mice; Models, Molecular; Motor Activity; N-Methylaspartate; Quinoxalines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tritium | 2001 |
Gabapentin actions on N-methyl-D-aspartate receptor channels are protein kinase C-dependent.
Topics: Acetates; Amines; Animals; Cell Separation; Cyclohexanecarboxylic Acids; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glycine; Immunohistochemistry; Male; N-Methylaspartate; Patch-Clamp Techniques; Protein Kinase C; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate | 2001 |
Glutamate inhibition of NMDA-induced hydroxyl radical release: an ontogenic study in rat.
Topics: Aging; Animals; Animals, Newborn; Brain; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hydroxyl Radical; Microdialysis; N-Methylaspartate; Neurons; Neurotoxins; Oxidative Stress; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Salicylates | 2001 |
Chronic ethanol exposure delays the 'developmental switch' of the NMDA receptor 2A and 2B subunits in cultured cerebellar granule neurons.
Topics: Animals; Animals, Newborn; Calcium; Cell Membrane; Cells, Cultured; Cerebellum; Ethanol; Gene Expression Regulation, Developmental; Glycine; Models, Neurological; N-Methylaspartate; Neurons; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic | 2001 |
Calretinin and calbindin D-28k delay the onset of cell death after excitotoxic stimulation in transfected P19 cells.
Topics: Animals; Calbindin 2; Calbindins; Calcium; Calcium-Binding Proteins; Cell Death; Cell Differentiation; Cell Size; Central Nervous System; Central Nervous System Diseases; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Glycine; Immunohistochemistry; L-Lactate Dehydrogenase; Membrane Potentials; Mice; N-Methylaspartate; Neoplastic Stem Cells; Neurons; Neuroprotective Agents; Neurotoxins; Parvalbumins; Receptors, N-Methyl-D-Aspartate; S100 Calcium Binding Protein G; Tretinoin | 2001 |
Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways.
Topics: Amino Acids; Animals; Astrocytes; Blotting, Northern; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Chromones; Corpus Striatum; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Flavonoids; Glycine; Immunoblotting; Immunohistochemistry; Male; MAP Kinase Signaling System; Mice; Morpholines; N-Methylaspartate; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2001 |
Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Animals; Cells, Cultured; Dithiothreitol; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Hydrogen-Ion Concentration; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neuroprotective Agents; Nootropic Agents; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sesquiterpenes; Spermine; Zinc | 2001 |
Suppression of presynaptic responses to adenosine by activation of NMDA receptors.
Topics: Action Potentials; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Baclofen; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; GABA Agonists; Glycine; Hippocampus; In Vitro Techniques; Kainic Acid; Long-Term Potentiation; Male; N-Methylaspartate; Phenethylamines; Presynaptic Terminals; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Time Factors; Triazines; Triazoles | 2001 |
The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding, Competitive; Brain; Cells, Cultured; Choline; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrophysiology; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Neurons; Nicotine; Nicotinic Agonists; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic | 2001 |
Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Action Potentials; Animals; Anticonvulsants; Benzoates; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Mice; Mice, Knockout; Muscarine; Muscarinic Agonists; N-Methylaspartate; Neostriatum; Neurons; Phenylacetates; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Synaptic Transmission | 2001 |
Effect of the group I metabotropic glutamate agonist DHPG on the visual cortex.
Topics: Action Potentials; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cats; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; N-Methylaspartate; Organ Culture Techniques; Phenylacetates; Presynaptic Terminals; Rats; Receptors, Metabotropic Glutamate; Resorcinols; Visual Cortex | 2001 |
Nitric oxide produced by non-motoneuron cells enhances rat embryonic motoneuron sensitivity to excitotoxins: comparison in mixed neuron/glia or purified cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Cell Communication; Cell Differentiation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Kainic Acid; Magnesium; N-Methylaspartate; Neuroglia; Neurotoxins; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2001 |
PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cholera Toxin; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Electrophysiology; Female; gamma-Aminobutyric Acid; Glycine; Heterotrimeric GTP-Binding Proteins; In Vitro Techniques; Male; N-Methylaspartate; Pain; Posterior Horn Cells; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, Prostaglandin; Synaptic Transmission | 2002 |
Specificity of putative partial agonist, 1-aminocyclopropanecarboxylic acid, for rat N-methyl-D-aspartate receptor subunits.
Topics: Amino Acids, Cyclic; Animals; Binding Sites; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Glycine; Hippocampus; Kinetics; N-Methylaspartate; Neurons; Neuroprotective Agents; Oocytes; Patch-Clamp Techniques; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Substrate Specificity; Xenopus laevis | 2002 |
In vivo effects of intracortical administration of NMDA and metabotropic glutamate receptors antagonists on neocortical long-term potentiation and conditioned taste aversion.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Benzoates; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Long-Term Potentiation; Male; Microinjections; N-Methylaspartate; Neocortex; Piperazines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Taste | 2002 |
Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits.
Topics: Animals; Calcium; Cations, Divalent; Central Nervous System; Cloning, Molecular; Electrophysiology; Glutamic Acid; Glycine; Immunohistochemistry; In Situ Hybridization; Ion Transport; Magnesium; Molecular Sequence Data; N-Methylaspartate; Neurons; Oocytes; Protein Subunits; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sequence Homology; Serine; Substrate Specificity; Xenopus laevis | 2002 |
Interaction of the hypocretins with neurotransmitters in the nucleus accumbens.
Topics: Action Potentials; Animals; Carrier Proteins; Drug Interactions; Electrophysiology; gamma-Aminobutyric Acid; Glycine; Intracellular Signaling Peptides and Proteins; Male; N-Methylaspartate; Neuropeptides; Neurotransmitter Agents; Nucleus Accumbens; Orexin Receptors; Orexins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Synaptic Transmission | 2002 |
Lower sensitivity to stress and altered monoaminergic neuronal function in mice lacking the NMDA receptor epsilon 4 subunit.
Topics: Animals; Behavior, Animal; Biogenic Monoamines; Calcium Radioisotopes; Corpus Striatum; Dizocilpine Maleate; Emotions; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Mice; Mice, Knockout; Motor Activity; N-Methylaspartate; Neurons; Prosencephalon; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Spatial Behavior; Stress, Physiological; Synaptosomes; Thalamus | 2002 |
Distinct NMDA receptors provide differential modes of transmission at mossy fiber-interneuron synapses.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Calcium; Chlorides; Cyclopropanes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Interneurons; Mossy Fibers, Hippocampal; N-Methylaspartate; Patch-Clamp Techniques; Phenols; Piperidines; Polyamines; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Valine | 2002 |
The NMDA type glutamate receptors expressed by primary rat osteoblasts have the same electrophysiological characteristics as neuronal receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Antagonists; Femur; Glycine; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons; Osteoblasts; Patch-Clamp Techniques; Perfusion; Rats; Receptors, N-Methyl-D-Aspartate | 2002 |
Metabotropic and NMDA glutamate receptor interactions with osmotic stimuli in supraoptic neurons.
Topics: Animals; Calcium Signaling; Cells, Cultured; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Agonists; Female; Glycine; Image Processing, Computer-Assisted; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Neurosecretory Systems; Osmolar Concentration; Pregnancy; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Supraoptic Nucleus | 2002 |
Electrophysiological evidence for expression of glycine receptors in freshly isolated neurons from nucleus accumbens.
Topics: Animals; Electrophysiology; Excitatory Amino Acid Agonists; GABA Agonists; Glycine; Glycine Agents; Male; Membrane Potentials; N-Methylaspartate; Neurons; Nucleus Accumbens; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Strychnine; Zinc | 2002 |
Group I metabotropic glutamate receptor-mediated enhancement of dopamine cell burst firing in rat ventral tegmental area in vitro.
Topics: Action Potentials; Animals; Apamin; Benzoates; Biological Clocks; Cycloleucine; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Receptors, Metabotropic Glutamate; Resorcinols; Ventral Tegmental Area | 2002 |
Activation of glutamate receptors inhibits Na/K-ATPase of cerebellum granule cells.
Topics: Alkaloids; Animals; Benzoates; Benzophenanthridines; Cerebellum; Cycloleucine; Cysteine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Glutamates; Glycine; Male; Mice; Mice, Inbred AKR; N-Methylaspartate; Neurons; Phenanthridines; Receptors, Glutamate; Sodium-Potassium-Exchanging ATPase | 2002 |
A site in the fourth membrane-associated domain of the N-methyl-D-aspartate receptor regulates desensitization and ion channel gating.
Topics: Amino Acid Sequence; Cell Line; Excitatory Amino Acid Agonists; Glycine; Humans; Ion Channel Gating; Methionine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylaspartate; Patch-Clamp Techniques; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, N-Methyl-D-Aspartate; Regression Analysis; Sequence Alignment | 2003 |
High frequency stimulation-induced dendritic calcium waves in rat hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Local; Animals; Benzoates; Calcium; Calcium Signaling; Dendrites; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glycine; Hippocampus; In Vitro Techniques; Lidocaine; Male; Microscopy, Confocal; N-Methylaspartate; Neurons; Organic Chemicals; Rats; Rats, Wistar | 2002 |
Conformational change in aspartate aminotransferase on substrate binding induces strain in the catalytic group and enhances catalysis.
Topics: Aspartate Aminotransferases; Aspartic Acid; Binding Sites; Catalysis; Escherichia coli; Glycine; Hydrogen-Ion Concentration; Kinetics; Ligands; Lysine; Malates; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; N-Methylaspartate; Oxygen; Photons; Plasmids; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Spectrophotometry; Tyrosine; Valine | 2003 |
Evidence against the presence of NMDA receptors at a central glutamatergic synapse in leeches.
Topics: 2-Amino-5-phosphonovalerate; Animals; Association Learning; Central Nervous System; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Kynurenic Acid; Leeches; Motor Neurons; N-Methylaspartate; Neurons, Afferent; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Reflex; Synapses; Synaptic Transmission | 2002 |
Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo.
Topics: Amino Acid Transport Systems, Neutral; Animals; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glycine; Glycine Plasma Membrane Transport Proteins; Iontophoresis; Male; N-Methylaspartate; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Prefrontal Cortex; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sarcosine; Serine | 2003 |
Human immunodeficiency virus type 1 gp120 and ethanol coexposure in rat organotypic brain slice cultures: Curtailment of gp120-induced neurotoxicity and neurotoxic mediators by moderate but not high ethanol concentrations.
Topics: Animals; Arachidonic Acid; Brain; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; Glycine; HIV Envelope Protein gp120; N-Methylaspartate; Nerve Degeneration; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Superoxides | 2003 |
Fast and slow locomotor burst generation in the hemispinal cord of the lamprey.
Topics: Action Potentials; Animals; Down-Regulation; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; In Vitro Techniques; Lampreys; Locomotion; N-Methylaspartate; Neural Inhibition; Spinal Cord; Spinal Nerve Roots; Swimming | 2003 |
[The role of glycine binding site in NMDA receptor--interactions between NMDA and D-serine in artificial anoxia/agycemia rat hippocampus].
Topics: Animals; Binding Sites; Glycine; Hippocampus; Hypoxia; In Vitro Techniques; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine | 2003 |
Glycine binding primes NMDA receptor internalization.
Topics: Adaptor Protein Complex beta Subunits; Amino Acid Sequence; Animals; Binding Sites; Dynamins; Electric Conductivity; Endocytosis; Enzyme-Linked Immunosorbent Assay; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; Ion Channel Gating; Macromolecular Substances; Molecular Sequence Data; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Precipitin Tests; Protein Binding; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2003 |
Pharmacokinetics and disposition of a novel NMDA glycine site antagonist (UK-240,455) in rats, dogs and man.
Topics: Adolescent; Adult; Animals; Bile; Binding Sites; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Central Nervous System; Dogs; Glycine; Humans; Male; Middle Aged; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tissue Distribution | 2003 |
Serotonin type II receptor activation facilitates synaptic plasticity via N-methyl-D-aspartate-mediated mechanism in the rat basolateral amygdala.
Topics: Amygdala; Animals; Calcium; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Excitatory Amino Acid Agonists; Fluorescent Dyes; Fura-2; Glycine; In Vitro Techniques; Indophenol; Ketanserin; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfonamides; Synaptic Transmission; Time Factors; Valine | 2003 |
Potentiation of N-methyl-D-aspartate-induced currents by the nootropic drug nefiracetam in rat cortical neurons.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Electrophysiology; Female; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Nootropic Agents; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 2003 |
Cooperativity between activation of metabotropic glutamate receptors and NMDA receptors in the induction of LTP in hippocampal CA1 neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Boron Compounds; Calcium; Cycloleucine; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; Glycine; Guinea Pigs; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Male; N-Methylaspartate; Neurons; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Time Factors | 2003 |
Mechanisms of action of CHF3381 in the forebrain.
Topics: Animals; Anticonvulsants; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electrophysiology; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Indans; Injections, Intraperitoneal; Ion Channel Gating; Male; N-Methylaspartate; Neurons; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sodium Channels | 2003 |
Inner retinal neurons display differential responses to N-methyl-D-aspartate receptor activation.
Topics: Adrenergic beta-Antagonists; Agmatine; Amacrine Cells; Animals; Betaxolol; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Immunohistochemistry; N-Methylaspartate; Neurons; Rabbits; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Synaptic Transmission | 2003 |
Excitotoxic hippocampal membrane breakdown and its inhibition by bilobalide: role of chloride fluxes.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Calcium; Calcium Isotopes; Cell Membrane; Chlorides; Choline; Cyclopentanes; Diterpenes; Diuretics; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Furans; Furosemide; Ginkgolides; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Potassium; Pyrrolidinones; Rats; Rats, Wistar; Synaptosomes | 2003 |
Neuroprotection against NMDA excitotoxicity by group I metabotropic glutamate receptors is associated with reduction of NMDA stimulated currents.
Topics: Animals; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; In Vitro Techniques; N-Methylaspartate; Neurons; Neurotoxins; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols | 2003 |
Glutamate receptors communicate with Na+/K+-ATPase in rat cerebellum granule cells: demonstration of differences in the action of several metabotropic and ionotropic glutamate agonists on intracellular reactive oxygen species and the sodium pump.
Topics: Animals; Cells, Cultured; Cerebellar Cortex; Dioxolanes; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fluorescent Dyes; Glycine; Male; N-Methylaspartate; Neurons; Purines; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Sodium-Potassium-Exchanging ATPase; Synaptic Transmission | 2003 |
Effect of ischaemia & aglycaemia on the synaptic transmission in neonatal rat spinal cord in vitro.
Topics: Animals; Animals, Newborn; Cell Hypoxia; Glucose; Glycine; Hypoxia; Ischemia; Magnesium; N-Methylaspartate; Oxygen; Perfusion; Rats; Spinal Cord; Spinal Nerve Roots; Synapses; Synaptic Transmission; Time Factors | 2003 |
Effects on cocaine and food self-administration of (+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, in rats.
Topics: Analysis of Variance; Animals; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Excitatory Amino Acid Agonists; Food; Glycine; Male; N-Methylaspartate; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Time Factors | 2004 |
Pulse of nitric oxide release in response to activation of N-methyl-D-aspartate receptors in the rat striatum: rapid desensitization, inhibition by receptor antagonists, and potentiation by glycine.
Topics: Animals; Drug Interactions; Excitatory Amino Acid Antagonists; Glycine; Male; N-Methylaspartate; Neostriatum; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2004 |
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae.
Topics: Alanine; Animals; Biguanides; Calcium Channel Blockers; Cattle; D-Aspartic Acid; Diltiazem; Dizocilpine Maleate; Drug Synergism; Glucose; Glutamic Acid; Glycine; Humans; Kainic Acid; N-Methylaspartate; Nitrendipine; omega-Conotoxins; Perfusion; Piperidines; Polyamines; Receptors, Glutamate; Retina; Tritium; Verapamil | 2003 |
Mechanism of action of galantamine on N-methyl-D-aspartate receptors in rat cortical neurons.
Topics: Animals; Binding Sites; Cells, Cultured; Cerebral Cortex; Cyclic AMP-Dependent Protein Kinases; Drug Synergism; Galantamine; Glycine; GTP-Binding Proteins; N-Methylaspartate; Neurons; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 2004 |
GABAA-receptor-mediated increase in intracellular Ca2+ concentration in the regenerating retina of adult newt.
Topics: Acetylcholine; Animals; Bicuculline; Calcium; Calcium Channel Blockers; Cell Count; Drug Interactions; Excitatory Amino Acid Agonists; Fluorescent Dyes; Fura-2; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Intracellular Space; Magnesium; N-Methylaspartate; Neurons; Receptors, GABA-A; Regeneration; Retina; Salamandridae; Verapamil | 2004 |
Electrophysiological characterization of N-methyl-D-aspartate receptors in rat dorsal root ganglia neurons.
Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Colon; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Glycine; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons, Afferent; Nociceptors; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Visceral Afferents | 2004 |
Interactions between NMDA receptors and mGlu5 receptors expressed in HEK293 cells.
Topics: Animals; Arsenicals; Cell Line; Drug Synergism; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Expression; Genistein; Glycine; Humans; N-Methylaspartate; Phosphorylation; Protein-Tyrosine Kinases; Rats; Receptor Cross-Talk; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Resorcinols; Staurosporine; Thapsigargin; Transfection; Tyrosine; Vanadates | 2004 |
External pH changes affect NMDA-evoked and spontaneous release of cholecystokinin, somatostatin and noradrenaline from rat cerebrocortical nerve endings.
Topics: Animals; Botulinum Toxins; Calcium; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Cholecystokinin; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glycine; Hydrogen-Ion Concentration; In Vitro Techniques; Male; N-Methylaspartate; Nerve Endings; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Norepinephrine; Potassium; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Serine; Somatostatin; Synaptosomes | 2004 |
Permissive role of adenosine A2A receptors on metabotropic glutamate receptor 5 (mGluR5)-mediated effects in the striatum.
Topics: Adenosine; Animals; Carbazoles; Cells, Cultured; Corpus Striatum; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glycine; In Vitro Techniques; Indoles; Male; Membrane Potentials; N-Methylaspartate; Phenethylamines; Phenylacetates; Pregnancy; Purinergic P1 Receptor Agonists; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Adenosine A2; Receptors, Metabotropic Glutamate; Triazines; Triazoles | 2004 |
Chronic ethanol induces synaptic but not extrasynaptic targeting of NMDA receptors.
Topics: Action Potentials; Adaptation, Physiological; Animals; Bicuculline; Biomarkers; Carbazoles; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dendrites; Dizocilpine Maleate; Ethanol; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Indoles; N-Methylaspartate; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Protein Transport; Pyrroles; Rats; Receptors, N-Methyl-D-Aspartate; Strychnine; Synapses; Synapsins; Tetrodotoxin | 2004 |
An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception, hyperalgesia, and morphine tolerance.
Topics: Analgesics, Opioid; Animals; Autoradiography; Behavior, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formaldehyde; Glycine; Hyperalgesia; Indoles; Injections, Spinal; Morphine; N-Methylaspartate; Narcotics; Oligonucleotides, Antisense; Pain; Pain Measurement; Rats; Reaction Time; Receptors, N-Methyl-D-Aspartate; RNA Probes; RNA, Messenger; Spinal Cord | 2005 |
Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Amino Acids; Animals; Aspartic Acid; Dicarboxylic Acids; Drug Interactions; Entorhinal Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; In Vitro Techniques; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission; Xanthenes | 2004 |
Understanding neurochemical changes during retinal diseases.
Topics: Animals; Betaxolol; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; N-Methylaspartate; Neurons; Retina; Retinal Diseases | 2004 |
Quantification of amino acid neurochemistry secondary to NMDA or betaxolol application.
Topics: Adrenergic beta-Antagonists; Agmatine; Amacrine Cells; Animals; Betaxolol; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Immunohistochemistry; N-Methylaspartate; Neurons; Rabbits; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells | 2004 |
Putative NMDA receptors in Hydra: a biochemical and functional study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Binding Sites; Cell Membrane; Concanavalin A; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Feeding Behavior; Glutamic Acid; Glutathione; Glycine; Hydra; Kynurenic Acid; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine; Strychnine | 2004 |
Transient Ca2+-permeable AMPA receptors in postnatal rat primary auditory neurons.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Benzodiazepines; Blotting, Western; Calcium; Cobalt; Cochlea; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Gene Expression Regulation, Developmental; Glycine; In Vitro Techniques; Microscopy, Confocal; N-Methylaspartate; Neurons; Parvalbumins; Peptides, Cyclic; Permeability; Rats; Rats, Wistar; Receptors, AMPA; Spider Venoms | 2004 |
Structural consequences of D481N/K483Q mutation at glycine binding site of NMDA ionotropic glutamate receptors: a molecular dynamics study.
Topics: Amino Acid Sequence; Binding Sites; Computer Simulation; Crystallography, X-Ray; Glycine; Hydrogen Bonding; Kynurenic Acid; Models, Molecular; Molecular Sequence Data; N-Methylaspartate; Point Mutation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid; Water | 2005 |
Modulatory effects mediated by metabotropic glutamate receptor 5 on lateral geniculate nucleus relay cells.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Cats; Drug Interactions; Female; Geniculate Bodies; Glycine; Iontophoresis; Male; N-Methylaspartate; Neurons; Phenylacetates; Photic Stimulation; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate | 2005 |
Modulation of striatal dopamine release by glycine transport inhibitors.
Topics: Amino Acid Transport Systems, Neutral; Animals; Biphenyl Compounds; Corpus Striatum; Dopamine; Excitatory Amino Acid Agonists; GABA Antagonists; GABA-B Receptor Antagonists; Glycine; Glycine Plasma Membrane Transport Proteins; Mice; Mice, Inbred BALB C; N-Methylaspartate; Organ Culture Techniques; Presynaptic Terminals; Receptors, GABA-B; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sarcosine; Schizophrenia; Synaptic Transmission | 2005 |
Divergent regulatory mechanisms governing BDNF mRNA expression in cerebral cortex and substantia nigra in response to striatal target ablation.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Corpus Striatum; Cyclopropanes; Denervation; Disease Models, Animal; Down-Regulation; Female; Glutamate Decarboxylase; Glycine; Huntington Disease; N-Methylaspartate; Neural Pathways; Neurons; Neurotoxins; Proto-Oncogene Proteins c-fos; Quinolinic Acid; Rats; Rats, Wistar; Receptor, trkB; RNA, Messenger; Substantia Nigra; Subthalamic Nucleus; Tyrosine 3-Monooxygenase | 2005 |
Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Apoptosis Inducing Factor; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; Benzodiazepines; Benzothiadiazines; Camptothecin; Caspase Inhibitors; Cells, Cultured; Cerebellum; Cerebral Cortex; Convulsants; Dizocilpine Maleate; Drug Resistance; Flavoproteins; Glutamic Acid; Glycine; Hippocampus; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Knockout; Mice, Mutant Strains; N-Methylaspartate; Neurons; Neurotoxins; Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Seizures | 2005 |
Effects of N-methyl-d-aspartate, glutamate, and glycine on the dorsal column axons of neonatal rat spinal cord: in vitro study.
Topics: Age Factors; Animals; Animals, Newborn; Axons; Cell Culture Techniques; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; N-Methylaspartate; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2005 |
Distinct roles of glycinergic and GABAergic inhibition in coordinating locomotor-like rhythms in the neonatal mouse spinal cord.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicuculline; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Membrane Potentials; Mice; Motor Activity; N-Methylaspartate; Neural Inhibition; Neurons; Patch-Clamp Techniques; Periodicity; Picrotoxin; Serotonin; Spinal Cord; Spinal Nerve Roots; Strychnine | 2005 |
Glycine binding site of the synaptic NMDA receptor in subpostremal NTS neurons.
Topics: Aminoquinolines; Animals; Animals, Newborn; Binding Sites; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Glycine Agents; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine; Solitary Nucleus; Strychnine; Synapses | 2005 |
Visualization of synaptic Ca2+ /calmodulin-dependent protein kinase II activity in living neurons.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Benzylamines; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Line; Diagnostic Imaging; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fluorescence Resonance Energy Transfer; Gene Expression; Glutamic Acid; Glycine; Hippocampus; Humans; Insecta; Luminescent Proteins; Microscopy, Confocal; Molecular Biology; Mutagenesis, Site-Directed; N-Methylaspartate; Neurons; Phosphorylation; Protein Binding; Quinoxalines; Sodium Channel Blockers; Sulfonamides; Synapses; Tetrodotoxin; Time Factors; Transfection | 2005 |
NSF interaction is important for direct insertion of GluR2 at synaptic sites.
Topics: Animals; Binding Sites; Cells, Cultured; Glycine; Hippocampus; N-Ethylmaleimide-Sensitive Proteins; N-Methylaspartate; Rats; Receptors, AMPA; Synapses; Vesicular Transport Proteins | 2005 |
Glutamate antagonists attenuate the action of NC-1900, a vasopressin fragment analog, on passive avoidance task performance in mice.
Topics: Animals; Avoidance Learning; Benzoates; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Memory; Mice; N-Methylaspartate; Oligopeptides; Pyrrolidonecarboxylic Acid; Receptors, Glutamate; Vasopressins | 2005 |
Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Etoposide; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Hydrolysis; Male; Membrane Potentials; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Neuroprotective Agents; Phenylacetates; Phosphatidylinositols; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Thiazoles | 2005 |
Long-term depression at olfactory nerve synapses.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium; Diagnostic Imaging; Dopamine Antagonists; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; In Vitro Techniques; Long-Term Synaptic Depression; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred ICR; N-Methylaspartate; Neurons; Olfactory Bulb; Patch-Clamp Techniques; Quinoxalines; Sodium Channel Blockers; Sulpiride; Synapses; Tetrodotoxin; Time Factors; Valine | 2005 |
Glutamate transporter type 3 attenuates the activation of N-methyl-D-aspartate receptors co-expressed in Xenopus oocytes.
Topics: Amino Acid Transport System X-AG; Animals; Gene Expression; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glycine; Membrane Potentials; N-Methylaspartate; Oocytes; Receptors, N-Methyl-D-Aspartate; Symporters; Xenopus laevis | 2005 |
Anteroventral third ventricular N-methyl-D-aspartate receptors, but not metabotropic glutamate receptors are involved in hemorrhagic AVP secretion.
Topics: Analysis of Variance; Angiotensin II; Animals; Blood Glucose; Blood Pressure; Dizocilpine Maleate; Drug Interactions; Electrolytes; Excitatory Amino Acid Antagonists; Glycine; Heart Rate; Hemorrhage; Hypothalamus; Injections, Intraventricular; Male; N-Methylaspartate; Osmolar Concentration; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Third Ventricle; Time Factors; Vasopressins; Wakefulness | 2005 |
Molecular interactions of the type 1 human immunodeficiency virus transregulatory protein Tat with N-methyl-d-aspartate receptor subunits.
Topics: Animals; Animals, Newborn; Chromatin; Drug Interactions; Gene Products, tat; Glycine; Hippocampus; Humans; Immunohistochemistry; Membrane Potentials; Microinjections; Microscopy, Confocal; Mutagenesis; N-Methylaspartate; Neurons; Oocytes; Patch-Clamp Techniques; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; Toxoids; Xenopus; Zinc | 2005 |
Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis.
Topics: Analysis of Variance; Animals; Animals, Newborn; Benzoates; Cell Count; Cell Death; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Estrenes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Glycine; Hippocampus; Immunohistochemistry; In Vitro Techniques; Methoxyhydroxyphenylglycol; Models, Biological; N-Methylaspartate; Nerve Tissue Proteins; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Propidium; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 2005 |
Voltage-sensitive and ligand-gated channels in differentiating neural stem-like cells derived from the nonhematopoietic fraction of human umbilical cord blood.
Topics: Antigens, CD34; Cell Differentiation; Cell Line; Electrophysiology; Excitatory Amino Acid Antagonists; Fetal Blood; Glycine; Humans; Immunohistochemistry; Ions; Kainic Acid; Leukocyte Common Antigens; Ligands; N-Methylaspartate; Neurons; Neurotransmitter Agents; Oligonucleotide Array Sequence Analysis; Patch-Clamp Techniques; Phenotype; Potassium; Receptors, GABA; Receptors, Glutamate; Sodium; Stem Cells; Umbilical Veins | 2005 |
Dual Ca2+ modulation of glycinergic synaptic currents in rodent hypoglossal motoneurones.
Topics: Animals; Benzoxazines; Calcium; Cannabinoid Receptor Modulators; Glutamic Acid; Glycine; Hypoglossal Nerve; In Vitro Techniques; Membrane Potentials; Mice; Morpholines; Motor Neurons; N-Methylaspartate; Naphthalenes; Neural Inhibition; Piperidines; Presynaptic Terminals; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cannabinoid; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Rimonabant; Synaptic Transmission | 2005 |
GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basic Helix-Loop-Helix Transcription Factors; Bicuculline; Bromodeoxyuridine; Calbindins; Calcium; Cell Count; Cell Differentiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Green Fluorescent Proteins; Hippocampus; History, Ancient; Immunohistochemistry; In Vitro Techniques; Intermediate Filament Proteins; Ki-67 Antigen; Membrane Potentials; Mice; Mice, Transgenic; Microscopy, Immunoelectron; N-Methylaspartate; Nerve Tissue Proteins; Nestin; Neural Cell Adhesion Molecule L1; Neurons; Nickel; Patch-Clamp Techniques; Phosphopyruvate Hydratase; Potassium Channel Blockers; S100 Calcium Binding Protein G; Sialic Acids; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Stem Cells; Tetrodotoxin; Vesicular Inhibitory Amino Acid Transport Proteins | 2005 |
Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: a possible key mechanism in the modulation of N-methyl-D-aspartate effects.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Bicuculline; Blotting, Western; Colforsin; Disks Large Homolog 4 Protein; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Fluorescent Antibody Technique; GABA Antagonists; Glycine; Hippocampus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phenethylamines; Phenylacetates; Pregnancy; Presynaptic Terminals; Pyridines; Qa-SNARE Proteins; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Adenosine A2; Receptors, Metabotropic Glutamate; Synaptophysin; Vesicular Glutamate Transport Protein 1 | 2005 |
Modulation of striatal dopamine release in vitro by agonists of the glycineB site of NMDA receptors; interaction with antipsychotics.
Topics: Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Haloperidol; Magnesium; Male; N-Methylaspartate; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Salicylamides | 2005 |
Na+ channel-mediated Ca2+ entry leads to glutamate secretion in mouse neocortical preplate.
Topics: Animals; Aspartic Acid; Brain; Calcium; Exocytosis; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Mice; Mice, Inbred C57BL; Models, Biological; N-Methylaspartate; Neocortex; Neurons; Receptors, AMPA; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sodium; Sodium Channels; Software; Taurine; Time Factors; Veratridine | 2005 |
Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Substitution; Animals; Binding Sites; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Green Fluorescent Proteins; Hippocampus; Humans; Ionomycin; Kidney; Models, Molecular; Mutation, Missense; N-Methylaspartate; Neuronal Plasticity; Phosphorylation; Point Mutation; Protein Binding; Protein Conformation; Protein Interaction Mapping; Protein Isoforms; Protein Processing, Post-Translational; Protein Transport; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Synapses; Transfection | 2006 |
Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect?
Topics: Animals; Anxiety; D-Amino-Acid Oxidase; Excitatory Amino Acid Antagonists; Fear; Glycine; Gyrus Cinguli; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Pain; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Stress, Psychological; Synaptic Transmission | 2006 |
Potentiation of the NMDA receptor-mediated responses through the activation of the glycine site by microglia secreting soluble factors.
Topics: Animals; Animals, Newborn; Cell Communication; Cells, Cultured; Culture Media, Conditioned; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Microglia; N-Methylaspartate; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission | 2006 |
Membrane channel properties of premotor excitatory burst neurons may underlie saccade slowing after lesions of omnipause neurons.
Topics: Action Potentials; Animals; Brain Stem; Computer Simulation; Functional Laterality; Glutamic Acid; Glycine; Ion Channels; Models, Neurological; N-Methylaspartate; Nerve Net; Neurons; Saccades | 2006 |
The neuroactive steroid pregnenolone sulfate stimulates the release of gonadotropin-releasing hormone from GT1-7 hypothalamic neurons, through N-methyl-D-aspartate receptors.
Topics: Animals; Cells, Cultured; Glutamic Acid; Glycine; Gonadotropin-Releasing Hormone; Hypothalamus; Mice; N-Methylaspartate; Pregnenolone; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Vesicular Glutamate Transport Protein 2 | 2006 |
Selective inhibition of spontaneous but not Ca2+ -dependent release machinery by presynaptic group II mGluRs in rat cerebellar slices.
Topics: Action Potentials; Animals; Cadmium; Calcium; Calcium Channels; Cerebellum; Colforsin; Cyclopropanes; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Interneurons; N-Methylaspartate; Nickel; Patch-Clamp Techniques; Presynaptic Terminals; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Vesicles | 2006 |
Characterization of a soluble ligand binding domain of the NMDA receptor regulatory subunit NR3A.
Topics: Amino Acid Sequence; Binding Sites; Glycine; Molecular Sequence Data; N-Methylaspartate; Protein Binding; Receptors, N-Methyl-D-Aspartate; Solubility | 2006 |
Reversible, activity-dependent targeting of profilin to neuronal nuclei.
Topics: Actins; Animals; Calcium; Cell Line; Cell Nucleus; Cells, Cultured; Cytoplasm; Dendritic Spines; Glycine; Green Fluorescent Proteins; Magnesium; Mice; Mice, Transgenic; Mutation; N-Methylaspartate; Neurons; Profilins; Protein Binding; Protein Transport; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Transfection | 2006 |
Low cerebrospinal fluid glutamate and glycine in refractory affective disorder.
Topics: Adult; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Chromatography, High Pressure Liquid; Depressive Disorder, Major; Drug Resistance; Electroconvulsive Therapy; Female; Glutamic Acid; Glycine; Humans; Male; Middle Aged; N-Methylaspartate; Statistics as Topic | 2007 |
Taurine potentiates presynaptic NMDA receptors in hippocampal Schaffer collateral axons.
Topics: Animals; Axons; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Organ Culture Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission; Taurine | 2006 |
Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo.
Topics: Amidohydrolases; Animals; Cell Death; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retinal Diseases; Retinal Ganglion Cells; Serine | 2006 |
Developmental switch from LTD to LTP in low frequency-induced plasticity.
Topics: Age Factors; Animals; Animals, Newborn; Benzoxazines; Calcium Channel Blockers; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glycine; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Morpholines; N-Methylaspartate; Naphthalenes; Phenylacetates; Piperidines; Pyrazoles; Rats | 2006 |
Nefiracetam potentiates N-methyl-D-aspartate (NMDA) receptor function via protein kinase C activation and reduces magnesium block of NMDA receptor.
Topics: Allosteric Regulation; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Electrochemistry; Glycine; Magnesium; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate | 2007 |
Neuroprotective mechanisms of taurine in vivo.
Topics: Ammonium Chloride; Amphetamines; Animals; Brain; Brain Chemistry; Central Nervous System Stimulants; Dopamine; Glutamic Acid; Glycine; Hydroxyl Radical; Male; Microdialysis; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sydnones; Taurine | 2006 |
[Effects of Ginkgo biloba extract against excitotoxicity induced by NMDA receptors and mechanism thereof].
Topics: Animals; Animals, Newborn; Brain Ischemia; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ginkgo biloba; Glycine; Hippocampus; Immunohistochemistry; Male; Membrane Potentials; Microtubule-Associated Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Plant Extracts; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury | 2006 |
Assessment of NMDA receptor activation in vivo by Fos induction after challenge with the direct NMDA agonist (tetrazol-5-yl)glycine: effects of clozapine and haloperidol.
Topics: Animals; Clozapine; Glycine; Haloperidol; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mice, Transgenic; N-Methylaspartate; Proto-Oncogene Proteins c-fos; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tetrazoles | 2007 |
Characterization of the gating conformational changes in the felbamate binding site in NMDA channels.
Topics: Animals; Animals, Newborn; Anticonvulsants; Binding Sites; Biophysical Phenomena; Biophysics; Felbamate; Glycine; In Vitro Techniques; Ion Channel Gating; Kinetics; N-Methylaspartate; Neurons; Phenylcarbamates; Propylene Glycols; Protein Conformation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2007 |
Functional interactions between presynaptic NMDA receptors and metabotropic glutamate receptors co-expressed on rat and human noradrenergic terminals.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Chromones; Female; Glycine; Hippocampus; Humans; Male; N-Methylaspartate; Norepinephrine; Presynaptic Terminals; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic; Resorcinols; Synaptosomes; Tritium | 2007 |
Endocannabinoid signalling triggered by NMDA receptor-mediated calcium entry into rat hippocampal neurons.
Topics: Animals; Animals, Newborn; Calcium Channels; Calcium Signaling; Cannabinoid Receptor Modulators; Cells, Cultured; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Endocannabinoids; Excitatory Amino Acid Agonists; Glycine; GTP-Binding Protein alpha Subunits, Gq-G11; Hippocampus; Inhibitory Postsynaptic Potentials; Lipoprotein Lipase; Morpholines; Muscarinic Agonists; N-Methylaspartate; Neurons; Oxotremorine; Phospholipase C beta; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Resorcinols | 2007 |
N-methyl-D-aspartate autoreceptors respond to low and high agonist concentrations by facilitating, respectively, exocytosis and carrier-mediated release of glutamate in rat hippocampus.
Topics: Animals; Aspartic Acid; Autoreceptors; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exocytosis; Glutamic Acid; Glycine; Hippocampus; HIV Envelope Protein gp120; Male; N-Methylaspartate; Presynaptic Terminals; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Synaptosomes; Vesicular Glutamate Transport Proteins | 2007 |
Sex-dependent differences in the activity and modulation of N-methyl-d-aspartic acid receptors in rat dorsal root ganglia neurons.
Topics: Action Potentials; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Estradiol; Estrogen Antagonists; Estrogens; Excitatory Amino Acid Agents; Female; Fulvestrant; Ganglia, Spinal; Glycine; Male; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sex Characteristics | 2007 |
Contribution of endogenous glycine and d-serine to excitotoxic and ischemic cell death in rat cerebrocortical slice cultures.
Topics: Animals; Animals, Newborn; Cell Death; Cell Survival; Cerebral Cortex; Excitatory Amino Acid Agonists; Glucose; Glycine; In Vitro Techniques; Ischemia; N-Methylaspartate; Oxygen; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine | 2007 |
Glycine stimulates the release of labeled acetylcholine but not dopamine nor glutamate from superfused rat striatal tissue.
Topics: Acetylcholine; Analysis of Variance; Animals; Antipsychotic Agents; Calcium; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Glycine Agents; Haloperidol; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Wistar; Sodium Channel Blockers; Tetrodotoxin; Time Factors; Tritium | 2007 |
Characterization of interactions between phencyclidine and amphetamine in rodent prefrontal cortex and striatum: implications in NMDA/glycine-site-mediated dopaminergic dysregulation and dopamine transporter function.
Topics: Amphetamine; Animals; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Glycine; Male; Microdialysis; N-Methylaspartate; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 2008 |
Role of glycine receptors and glycine release for the neuroprotective activity of bilobalide.
Topics: Animals; Binding Sites; Binding, Competitive; Brain Edema; Brain Ischemia; Chlorides; Choline; Cyclopentanes; Excitatory Amino Acid Agonists; Furans; Ginkgolides; Glycine; Hippocampus; Male; Membrane Lipids; N-Methylaspartate; Neuroprotective Agents; Organ Culture Techniques; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 2008 |
The role of NMDA receptors in regulating group II metabotropic glutamate receptor-mediated long-term depression in rat medial prefrontal cortex.
Topics: Amino Acids; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Long-Term Synaptic Depression; Male; N-Methylaspartate; Patch-Clamp Techniques; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Valine | 2008 |
N-methyl-D-aspartate triggers neonatal rat hypoglossal motoneurons in vitro to express rhythmic bursting with unusual Mg2+ sensitivity.
Topics: Animals; Animals, Newborn; Electrophysiology; Evoked Potentials, Motor; Excitatory Amino Acid Agonists; Extracellular Space; gamma-Aminobutyric Acid; Glycine; Hypoglossal Nerve; Immunohistochemistry; In Vitro Techniques; Magnesium; Membrane Potentials; Motor Neurons; N-Methylaspartate; Nerve Net; Neural Conduction; Patch-Clamp Techniques; Potassium Channels; Rats; Sodium Channel Blockers; Synapses; Tetrodotoxin | 2008 |
Expression of adenosine A 2A receptors in the rat lumbar spinal cord and implications in the modulation of N-methyl-d-aspartate receptor currents.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Blotting, Western; Glycine; Lumbosacral Region; Membrane Potentials; N-Methylaspartate; Pain; Patch-Clamp Techniques; Phenethylamines; Posterior Horn Cells; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord; Substantia Gelatinosa | 2008 |
NMDA and GABA B receptors are involved in controlling nematocyst discharge in hydra.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Dose-Response Relationship, Drug; Epinephrine; Glutamic Acid; Glycine; Hydra; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Receptors, GABA-B; Serotonin | 2008 |
N-methyl-D-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein.
Topics: Animals; Apolipoproteins E; Binding Sites; Cell Line, Transformed; Cell Membrane; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Glycine; Humans; LDL-Receptor Related Proteins; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Peptide Fragments; Protein Binding; Receptors, N-Methyl-D-Aspartate; Spermine; Transfection | 2008 |
Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Discrimination, Psychological; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extracellular Space; Gerbillinae; Glycine; Glycine Plasma Membrane Transport Proteins; Male; Mice; Motor Activity; N-Methylaspartate; Phencyclidine; Recognition, Psychology; Reflex, Startle; Schizophrenia; Stereoisomerism; Swimming | 2008 |
Activity-dependent shedding of the NMDA receptor glycine binding site by matrix metalloproteinase 3: a PUTATIVE mechanism of postsynaptic plasticity.
Topics: Animals; Central Nervous System; Glycine; Matrix Metalloproteinase 3; N-Methylaspartate; Neuronal Plasticity; Neurons; Protein Kinase C; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spinal Cord; Synapses | 2008 |
Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Microscopy, Electron, Scanning; N-Methylaspartate; Potassium Chloride; Pregnenolone; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tritium; Valine | 2008 |
A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function.
Topics: Actin Depolymerizing Factors; Animals; Animals, Newborn; Biophysics; Cells, Cultured; Dendritic Spines; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Glycine; Glycine Agents; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Mice; Mice, Knockout; Microscopy, Electron, Transmission; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phalloidine; rho-Associated Kinases; Synapses; Synapsins; Vesicular Glutamate Transport Protein 1 | 2009 |
Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function.
Topics: Age Factors; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Calcium; Cells, Cultured; Cerebral Cortex; Drug Interactions; Fibrinolysin; Glutamic Acid; Glycine; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Oocytes; Patch-Clamp Techniques; Protease Nexins; rap GTP-Binding Proteins; Rats; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Thrombin; Tissue Plasminogen Activator; Xenopus laevis | 2008 |
NMDA-mediated modulation of dopamine release is modified in rat prefrontal cortex and nucleus accumbens after chronic nicotine treatment.
Topics: Analysis of Variance; Animals; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Male; N-Methylaspartate; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Pipecolic Acids; Potassium; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Synaptosomes; Time Factors; Tritium | 2009 |
Tyrosine dephosphorylation regulates AMPAR internalisation in mGluR-LTD.
Topics: Amino Acid Sequence; Animals; Endocytosis; Excitatory Amino Acid Agonists; Female; Glycine; Hippocampus; Long-Term Synaptic Depression; Molecular Sequence Data; N-Methylaspartate; Phosphorylation; Protein Subunits; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Metabotropic Glutamate; Resorcinols; Sequence Alignment; Synapses; Tyrosine | 2009 |
Reprogramming chick RPE progeny cells to differentiate towards retinal neurons by ash1.
Topics: Animals; Avian Proteins; Basic Helix-Loop-Helix Transcription Factors; Biomarkers; Cell Differentiation; Cells, Cultured; Cellular Reprogramming; Chick Embryo; Gene Expression Regulation, Developmental; Glutamic Acid; Glycine; Immunohistochemistry; N-Methylaspartate; Neuroglia; Retinal Neurons; Retinal Pigment Epithelium; Retroviridae; Stem Cells; Vimentin; Virus Replication | 2008 |
Glutamatergic modulation of cerebellar interneuron activity is mediated by an enhancement of GABA release and requires protein kinase A/RIM1alpha signaling.
Topics: Action Potentials; Animals; Animals, Newborn; Cerebellum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; GTP-Binding Proteins; In Vitro Techniques; Interneurons; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Patch-Clamp Techniques; Pyridazines; Signal Transduction; Synaptic Potentials | 2009 |
Discovery of GlyT1 inhibitors with improved pharmacokinetic properties.
Topics: Animals; Dogs; Drug Discovery; Glycine; Glycine Plasma Membrane Transport Proteins; Humans; Mice; Mice, Inbred DBA; N-Methylaspartate; Piperidines; Rats; Substrate Specificity; Sulfonamides | 2009 |
Interaction of dopamine D1 with NMDA NR1 receptors in rat prefrontal cortex.
Topics: Animals; Benzazepines; Calcium; Cells, Cultured; Cyclic AMP; Embryo, Mammalian; Enzyme Inhibitors; Glycine; Immunoprecipitation; In Vitro Techniques; Isoquinolines; N-Methylaspartate; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Subcellular Fractions; Sulfonamides | 2009 |
The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B.
Topics: Amino Acid Sequence; Animals; Cell Line; Conotoxins; Excitatory Amino Acid Antagonists; Glycine; Humans; Membrane Potentials; Models, Molecular; Molecular Sequence Data; N-Methylaspartate; Patch-Clamp Techniques; Piperidines; Point Mutation; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins | 2009 |
The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine.
Topics: Animals; Antipsychotic Agents; Calcium Signaling; Cell Death; Cells, Cultured; Electrophysiological Phenomena; Glycine; Glycine Plasma Membrane Transport Proteins; Hippocampus; Humans; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Sarcosine; Schizophrenia; Sodium | 2009 |
Interference with cellular differentiation by D-serine through antagonism at N-methyl-D-aspartate receptors composed of NR1 and NR3A subunits in chondrocytes.
Topics: Alkaline Phosphatase; Animals; Animals, Newborn; Calcification, Physiologic; Calcium; Cell Differentiation; Chlorocebus aethiops; Chondrocytes; Chondrogenesis; Core Binding Factor Alpha 1 Subunit; COS Cells; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Gestational Age; Glycine; Humans; Membrane Glycoproteins; Metatarsal Bones; Mice; Mice, Knockout; N-Methylaspartate; Osteopontin; Racemases and Epimerases; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Serine; Time Factors; Tissue Culture Techniques; Transfection | 2009 |
Adenosine A2A receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum.
Topics: Action Potentials; Animals; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Cerebral Cortex; Corpus Striatum; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Agonists; Female; Glycine; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Mice; Mice, Knockout; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Phenylacetates; Piperidines; Pregnancy; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Adenosine A2; Synapses; Triazines; Triazoles | 2009 |
Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain.
Topics: Analgesics; Animals; Anti-Infective Agents; Biphenyl Compounds; Dinoprostone; Excitatory Amino Acid Agents; Glycine; Immunohistochemistry; Inflammation; Lignans; Male; Mice; N-Methylaspartate; Phenylacetates; Proto-Oncogene Proteins c-fos; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate | 2009 |
Assessment of different induction protocols to elicit long-term depression (LTD) in the rat visual cortex in vivo.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics; Animals; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Geniculate Bodies; Glycine; Long-Term Synaptic Depression; Male; N-Methylaspartate; Pentobarbital; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate; Synaptic Potentials; Urethane; Visual Cortex; Visual Pathways | 2010 |
The glycine transporter GlyT1 controls N-methyl-D-aspartic acid receptor coagonist occupancy in the mouse retina.
Topics: Animals; Glycine; Glycine Plasma Membrane Transport Proteins; In Vitro Techniques; Mice; Mice, Transgenic; N-Methylaspartate; Neural Inhibition; Photic Stimulation; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Synapses; Vision, Ocular | 2009 |
Activation of N-methyl-D-aspartate (NMDA) receptors in the dorsal vagal complex lowers glucose production.
Topics: 2-Amino-5-phosphonovalerate; Animals; Gene Knockdown Techniques; Glucose; Glycine; Humans; Kynurenic Acid; Liver; Male; N-Methylaspartate; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Vagotomy; Vagus Nerve | 2010 |
Reverse osmosis followed by activated carbon filtration for efficient removal of organic micropollutants from river bank filtrate.
Topics: Benzene Derivatives; Carbon; Dioxanes; Equipment Design; Filtration; Glycine; Glyphosate; N-Methylaspartate; Naphthalenes; Organic Chemicals; Osmosis; Rivers; Water Pollutants; Water Pollutants, Chemical | 2010 |
Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.
Topics: Animals; Binding, Competitive; Calcium Signaling; Cell Line, Tumor; Cell Membrane; Cerebral Cortex; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fluorometry; Glutamic Acid; Glycine; HEK293 Cells; Humans; Male; Molecular Structure; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Transfection | 2010 |
N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn.
Topics: Animals; Arachidonic Acids; Glycine; Inhibitory Postsynaptic Potentials; Miniature Postsynaptic Potentials; N-Methylaspartate; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sarcosine; Serine; Spinal Cord; Synaptic Transmission | 2010 |
Cytosolic zinc release and clearance in hippocampal neurons exposed to glutamate--the role of pH and sodium.
Topics: Animals; Calcium; Cells, Cultured; Chelating Agents; Cytosol; Dose-Response Relationship, Drug; Edetic Acid; Embryo, Mammalian; Ethylenediamines; Excitatory Amino Acid Agonists; Fura-2; Glutamic Acid; Glycine; Hippocampus; Hydrogen-Ion Concentration; Mice; N-Methylaspartate; Neurons; Polycyclic Compounds; Sodium; Statistics, Nonparametric; Zinc | 2011 |
Increased hippocampal glycine uptake and cognitive dysfunction after peripheral nerve injury.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Exploratory Behavior; Fluoroacetates; Glycine; Herb-Drug Interactions; Hippocampus; Hyperalgesia; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbred Strains; Motor Activity; N-Methylaspartate; Neurons; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Recognition, Psychology; Sarcosine; Sciatic Neuropathy | 2011 |
Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions.
Topics: Animals; Aspartic Acid; Calcium; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Hippocampus; Immunoprecipitation; Magnesium; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tetrahydronaphthalenes; Tritium | 2011 |
Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Ataxia; Cerebral Cortex; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Rats; Rats, Wistar; Reaction Time; Seizures; Spider Venoms; Synaptosomes; Tritium | 2011 |
Activation of glycine site and GluN2B subunit of NMDA receptors is necessary for ERK/CREB signaling cascade in rostral anterior cingulate cortex in rats: implications for affective pain.
Topics: Animals; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; Glycine; Gyrus Cinguli; Male; N-Methylaspartate; Pain; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2012 |
A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction.
Topics: Analysis of Variance; Biophysical Phenomena; Calcium; Cell Line, Transformed; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Glycine; Humans; Ion Channel Gating; Magnesium; Membrane Potentials; Models, Molecular; Mutagenesis; N-Methylaspartate; Patch-Clamp Techniques; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Transfection | 2012 |
Timing-dependent reduction in ethanol sedation and drinking preference by NMDA receptor co-agonist d-serine.
Topics: Alcohol Drinking; Alcoholic Intoxication; Analysis of Variance; Animals; Ethanol; Glutamic Acid; Glycine; Male; Mice; Motor Activity; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine; Time Factors | 2012 |
Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors.
Topics: Animals; Cells, Cultured; Diamines; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Glycine; Magnesium; Memantine; N-Methylaspartate; Oocytes; Phenols; Polyamines; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 2012 |
Mild activation of poly(ADP-ribose) polymerase (PARP) is neuroprotective in rat hippocampal slice models of ischemic tolerance.
Topics: Amino Acid Chloromethyl Ketones; Animals; Caspase 3; Caspase 7; Caspase Inhibitors; Cell Death; Cell Hypoxia; Cells, Cultured; Glucose; Glycine; Hippocampus; Ischemic Preconditioning; Isoquinolines; MAP Kinase Signaling System; N-Methylaspartate; Neurons; Neuroprotective Agents; Phenanthrenes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Resorcinols; Thiophenes | 2012 |
[Inhibitory regulation of glutamate receptors in the frog motoneuron].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Evoked Potentials; Excitatory Amino Acids; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Kainic Acid; Microelectrodes; Motor Neurons; N-Methylaspartate; Organ Culture Techniques; Poisons; Pyridazines; Rana ridibunda; Receptors, Ionotropic Glutamate; Spinal Cord; Strychnine | 2012 |
Novel glycine-dependent inactivation of NMDA receptors in cultured hippocampal neurons.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Glycine; Hippocampus; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2012 |
Dual effect of 17β-estradiol on NMDA-induced neuronal death: involvement of metabotropic glutamate receptor 1.
Topics: Animals; Astrocytes; Butadienes; Calpain; Catechols; Cell Death; Cerebral Cortex; Enzyme Inhibitors; Estradiol; Extracellular Signal-Regulated MAP Kinases; Glycine; Mice; Models, Biological; N-Methylaspartate; Neurons; Nitriles; Phosphorylation; Receptors, Estrogen; Receptors, Metabotropic Glutamate | 2012 |
Mechanistic and structural determinants of NMDA receptor voltage-dependent gating and slow Mg2+ unblock.
Topics: Biophysical Phenomena; Biophysics; Glutamic Acid; Glycine; Green Fluorescent Proteins; HEK293 Cells; Humans; Ion Channel Gating; Magnesium; Membrane Potentials; Models, Biological; N-Methylaspartate; Nerve Tissue Proteins; Patch-Clamp Techniques; Protein Conformation; Receptors, N-Methyl-D-Aspartate; Transfection | 2013 |
Triheteromeric NMDA receptors at hippocampal synapses.
Topics: Animals; Animals, Newborn; Biophysical Phenomena; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Synapses | 2013 |
Glycine transporter 1 modulates GABA release from amacrine cells by controlling occupancy of coagonist binding site of NMDA receptors.
Topics: Amacrine Cells; Animals; Axons; Binding Sites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fish Proteins; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Glycine Agents; Glycine Plasma Membrane Transport Proteins; Goldfish; Inhibitory Postsynaptic Potentials; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine; Strychnine | 2013 |
Pharmacological characterization of NMDA-like receptors in the single-celled organism Paramecium primaurelia.
Topics: Calcium; Glycine; N-Methylaspartate; Paramecium; Protozoan Proteins; Receptors, N-Methyl-D-Aspartate; Swimming | 2014 |
Neuronal and nonneuronal COX-2 expression confers neurotoxic and neuroprotective phenotypes in response to excitotoxin challenge.
Topics: Analysis of Variance; Animals; Antigens, Differentiation; Cyclooxygenase 2; Disease Models, Animal; Gene Expression Regulation; Glycine; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Phosphopyruvate Hydratase; Tetrazoles | 2014 |
NMDA receptor activation antagonizes the NMDA antagonist-induced antianxiety effect in the elevated plus-maze test in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Binding Sites; Brain; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Ligands; Male; Maze Learning; Mice; N-Methylaspartate; Quinolones; Receptors, N-Methyl-D-Aspartate; Serine | 2013 |
Activation of mGluR5 attenuates NMDA-induced neurotoxicity through disruption of the NMDAR-PSD-95 complex and preservation of mitochondrial function in differentiated PC12 cells.
Topics: Animals; Apoptosis; Calcium; Cell Differentiation; Cell Survival; Cytochromes c; Disks Large Homolog 4 Protein; Glycine; Intracellular Signaling Peptides and Proteins; Membrane Potential, Mitochondrial; Membrane Proteins; Mitochondria; N-Methylaspartate; PC12 Cells; Phenylacetates; Protein Binding; Rats; Reactive Oxygen Species; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 2014 |
Glycine induces bidirectional modifications in N-methyl-D-aspartate receptor-mediated synaptic responses in hippocampal CA1 neurons.
Topics: Animals; Binding Sites; Biological Transport; Brain; CA1 Region, Hippocampal; Electrophysiology; Excitatory Postsynaptic Potentials; Glycine; Male; Membrane Glycoproteins; N-Methylaspartate; Neuronal Plasticity; Neurons; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Synapses | 2014 |
Glycine transporters type 1 inhibitor promotes brain preconditioning against NMDA-induced excitotoxicity.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Agonists; Fluoresceins; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Hippocampus; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurotoxicity Syndromes; Sarcosine; Time Factors; Tritium | 2015 |
Heteromerization of ligand binding domains of N-methyl-D-aspartate receptor requires both coagonists, L-glutamate and glycine.
Topics: Animals; Glutamic Acid; Glycine; Ion Channel Gating; Ligands; Mice; Models, Molecular; N-Methylaspartate; Protein Multimerization; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate | 2015 |
Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Extracellular Space; Glutamic Acid; Glycine; Hippocampus; Mice, Knockout; Microdialysis; N-Methylaspartate; Neurons; Racemases and Epimerases; Receptors, N-Methyl-D-Aspartate; Serine; Taurine | 2015 |
Functional plasticity of the N-methyl-d-aspartate receptor in differentiating human erythroid precursor cells.
Topics: Adolescent; Adult; Apoptosis; Calcium; Cells, Cultured; Erythroid Precursor Cells; Erythropoiesis; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Flow Cytometry; Glycine; Humans; Kinetics; Male; Membrane Potentials; Middle Aged; N-Methylaspartate; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Signal Transduction; Young Adult | 2015 |
Intracellular zinc is a critical intermediate in the excitotoxic cascade.
Topics: Animals; Calcium; Cells, Cultured; Corpus Striatum; Embryo, Mammalian; Excitatory Amino Acid Agonists; Extracellular Fluid; Glycine; L-Lactate Dehydrogenase (Cytochrome); Male; Membrane Potential, Mitochondrial; Mice; N-Methylaspartate; NADPH Dehydrogenase; Neurons; Nitric Oxide Synthase Type I; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Zinc | 2015 |
Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells.
Topics: Animals; Apoptosis; Astrocytes; Calcium; Cell Division; Cells, Cultured; Cerebral Cortex; Culture Media; DNA Damage; Dose-Response Relationship, Drug; Extracellular Fluid; Glycine; Intercellular Signaling Peptides and Proteins; Ketamine; Mitochondria; N-Methylaspartate; Necrosis; Nerve Degeneration; Neural Stem Cells; Neurogenesis; Neurons; Oligodendroglia; Rats; Rats, Sprague-Dawley | 2015 |
Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors.
Topics: Animals; Cell Membrane; Down-Regulation; Endocytosis; Enzyme Activation; Gene Knockdown Techniques; Glycine; HEK293 Cells; Humans; Methoxyhydroxyphenylglycol; Mice; Models, Biological; N-Methylaspartate; Phosphorylation; Phosphoserine; Protein Kinase C; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2015 |
1-Deoxysphingolipid-induced neurotoxicity involves N-methyl-d-aspartate receptor signaling.
Topics: Animals; Cell Line, Tumor; Cerebral Cortex; Cytoskeleton; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Humans; Memantine; Membrane Potentials; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Neuroprotective Agents; rac1 GTP-Binding Protein; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sphingolipids; Sphingosine | 2016 |
Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase.
Topics: Animals; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Glycine; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mitogen-Activated Protein Kinase 10; Mitogen-Activated Protein Kinase 9; N-Methylaspartate; Presynaptic Terminals; Receptors, N-Methyl-D-Aspartate; SNARE Proteins; Synaptosomes | 2017 |
Neurotoxicity of propofol on rat hypoglossal motoneurons in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Intravenous; Animals; Animals, Newborn; Apoptosis Inducing Factor; Cell Count; gamma-Aminobutyric Acid; Glycine; Hypoglossal Nerve; In Vitro Techniques; Motor Neurons; N-Methylaspartate; Patch-Clamp Techniques; Propofol; Rats, Wistar | 2017 |
De novo mutations in GRIN1 cause extensive bilateral polymicrogyria.
Topics: Animals; Child; Child, Preschool; DNA Mutational Analysis; Excitatory Amino Acid Agonists; Family Health; Female; Glutamic Acid; Glycine; HEK293 Cells; Humans; Infant; Magnetic Resonance Imaging; Male; Membrane Potentials; Models, Molecular; Mutagenesis; Mutation; N-Methylaspartate; Nerve Tissue Proteins; Patch-Clamp Techniques; Polymicrogyria; Rats; Receptors, N-Methyl-D-Aspartate; Transfection | 2018 |
DAPK1-ERK signal mediates oxygen glucose deprivation reperfusion induced apoptosis in mouse N2a cells.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cerebral Cortex; Cytarabine; Death-Associated Protein Kinases; Disease Models, Animal; Excitatory Amino Acid Agonists; Glucose; Glycine; Hypoxia; Immunosuppressive Agents; Infarction, Middle Cerebral Artery; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuroblastoma; Neurons; Protein Biosynthesis; RNA, Small Interfering | 2018 |
Neuronal Activity-Dependent Activation of Astroglial Calcineurin in Mouse Primary Hippocampal Cultures.
Topics: Animals; Astrocytes; Calcineurin; Calcium; Cell Nucleus; Cells, Cultured; Cytosol; Genetic Vectors; Glycine; Hippocampus; Long-Term Potentiation; Mice, Inbred C57BL; Models, Biological; N-Methylaspartate; Neuroglia; Neurons; Receptor, Metabotropic Glutamate 5; Reproducibility of Results; Resorcinols | 2018 |
Protective Effect of N-Arachidonoyl Glycine-GPR18 Signaling after Excitotoxical Lesion in Murine Organotypic Hippocampal Slice Cultures.
Topics: Animals; Arachidonic Acids; Astrocytes; Endocannabinoids; Glycine; Hippocampus; Mice; Mice, Inbred C57BL; Microglia; N-Methylaspartate; Neurons; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Signal Transduction | 2019 |
A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling.
Topics: Animals; Bicuculline; Cells, Cultured; GABA-A Receptor Antagonists; Glutamic Acid; Glycine; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; MicroRNAs; N-Methylaspartate; Neurotoxins; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Ribonuclease III; Seizures; Signal Transduction; Specific Pathogen-Free Organisms; Subcellular Fractions; Transcriptome; Up-Regulation | 2020 |
Differential mechanisms of tolerance induced by NMDA and 3,5-dihydroxyphenylglycine (DHPG) preconditioning.
Topics: Animals; Cell Hypoxia; Drug Tolerance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glucose; Glycine; Hippocampus; Ischemic Preconditioning; Male; N-Methylaspartate; Neuroprotection; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, AMPA; Resorcinols | 2020 |
A Study of the Participation of NMDA Glutamate Receptors in the Mechanisms of Specific Anterograde Amnesia Reversion.
Topics: Amnesia; Amnesia, Anterograde; Animals; Avoidance Learning; Conditioning, Classical; Cycloserine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Helix, Snails; Memory; Memory, Long-Term; Memory, Short-Term; Models, Animal; N-Methylaspartate; Neuronal Plasticity; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Reproducibility of Results; Synapses | 2020 |
Long Noncoding RNA Expression Profiles of Rat Extrasynaptic and Synaptic Neurons Expressing the N-methyl-D-Aspartate Receptor Revealed by Microarray Analysis.
Topics: 4-Aminopyridine; Animals; Bicuculline; Cerebral Cortex; Down-Regulation; Excitatory Amino Acid Agonists; GABA-A Receptor Antagonists; Glycine; Glycine Agents; Microarray Analysis; N-Methylaspartate; Neurons; Polymerase Chain Reaction; Potassium Channel Blockers; Primary Cell Culture; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Long Noncoding; Synapses; Up-Regulation | 2021 |
Computational Molecular Characterization of the Interaction of Acetylcholine and the NMDA Receptor to Explain the Direct Glycine-Competitive Potentiation of NMDA-Mediated Neuronal Currents.
Topics: Acetylcholine; Glycine; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate | 2022 |
Activation of non-classical NMDA receptors by glycine impairs barrier function of brain endothelial cells.
Topics: Animals; Blood-Brain Barrier; Endothelial Cells; Glycine; Mice; N-Methylaspartate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 2022 |
Pharmacological characterization and differential expression of NMDA receptor subunits in the chicken vestibular system during development.
Topics: Animals; Chickens; Glycine; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Vestibular System | 2023 |
Changes in NMDA Receptor Function in Rapid Ischemic Tolerance: A Potential Role for Tri-Heteromeric NMDA Receptors.
Topics: Actins; Animals; Glycine; Ischemia; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate | 2022 |
Two gates mediate NMDA receptor activity and are under subunit-specific regulation.
Topics: Glycine; Ion Channel Gating; Molecular Dynamics Simulation; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate | 2023 |
Astrocyte Calcium Signaling Shifts the Polarity of Presynaptic Plasticity.
Topics: Astrocytes; Calcium; Calcium Signaling; Glutamates; Glycine; N-Methylaspartate; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2023 |
Design, synthesis and evaluation of novel 1-phenyl-pyrrolo[1,2-b]isoquinolin-3-one derivatives as antagonists for the glycine binding site of the NMDA receptor.
Topics: Animals; Binding Sites; Glycine; Molecular Docking Simulation; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate | 2023 |