n-methylaspartate has been researched along with glutamic acid in 1740 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 189 (10.86) | 18.7374 |
| 1990's | 768 (44.14) | 18.2507 |
| 2000's | 519 (29.83) | 29.6817 |
| 2010's | 203 (11.67) | 24.3611 |
| 2020's | 61 (3.51) | 2.80 |
| Authors | Studies |
|---|---|
| Calligaro, DO; Heinz, LJ; Lunn, WH; O'Malley, PJ; Salhoff, CR; Schoepp, DD; Vasileff, RT | 1 |
| Bigge, CF; Bobovski, TP; Brahce, LJ; Coughenour, LL; Drummond, JT; Hays, SJ; Johnson, G; Novak, PM; Rice, MJ | 1 |
| Araldi, GL; Kozikowski, AP; Pshenichkin, S; Steensma, D; Surina, E; Tückmantel, W; Wang, S; Wroblewski, JT | 1 |
| Bräuner-Osborne, H; Conti, P; De Amici, M; De Micheli, C; De Sarro, G; Madsen, U; Rizzo, M; Stensbøl, TB; Toma, L | 1 |
| Bräuner-Osborne, H; Egebjerg, J; Krogsgaard-Larsen, P; Madsen, U; Nielsen, EO | 1 |
| Bräuner-Osborne, H; Christensen, C; Clausen, RP; Egebjerg, J; Greenwood, JR; Hansen, KB; Jørgensen, L; Kristensen, JL; Madsen, JC; Micale, N; Nielsen, B; Traynelis, SF | 1 |
| Amir, A; Contreras-Sanz, A; Foti, A; Fruttero, R; Gasco, A; Giordano, C; Hansen, KB; Johansen, TN; Lolli, ML; Nielsen, B; Pickering, DS; Rolando, B | 1 |
| Boschi, D; Clausen, RP; Farnsworth, JC; Hansen, KB; Jensen, AA; Kastrup, JS; Lolli, ML; Møllerud, S; Nielsen, B; Passoni, A; Pickering, DS; Sainas, S; Temperini, P; Yi, F | 1 |
| Beal, MF; Finn, SF; Kowall, NW; Mazurek, MF; Storey, E | 1 |
| Maruyama, M; Nakazawa, M; Takeda, K | 1 |
| Becker, DP; Hovda, DA; Katayama, Y; Kawamata, T; Yoshino, A | 1 |
| Andrews, H; Thukral, V; Wang, JK | 1 |
| Amin, S; Leitner, M; Rosenberg, PA | 1 |
| Butler, TW; Chenard, BL; Prochniak, MA; Shalaby, IA | 1 |
| Carbone, S; Moguilevsky, JA; Otero Losada, ME; Szwarcfarb, B | 1 |
| Jensen, TS; Yaksh, TL | 1 |
| Buchan, AM | 1 |
| Hisanaga, K; Sagar, SM; Sharp, FR | 1 |
| Brann, DW; Mahesh, VB | 1 |
| Kurtz, HJ; Larson, AA; Skilling, SR; Sun, X | 1 |
| Burnashev, N; Herb, A; Higuchi, M; Lomeli, H; Monyer, H; Sakmann, B; Schoepfer, R; Seeburg, PH; Sprengel, R | 1 |
| Connor, JA; Wadman, WJ | 1 |
| Näsström, JB; Perl, ER; Schneider, SP | 1 |
| Akoev, GN; Andrianov, GN; Ryzhova, IV; Sherman, NO | 1 |
| Henry, JL; Hong, YG | 1 |
| Cornell-Bell, AH; Finkbeiner, SM; van den Pol, AN | 1 |
| Huettner, JE; Koroshetz, WJ; Rees, AH; Swartz, KJ | 1 |
| Blanco, P; Börner, C; Martínez-Serrano, A; Satrústegui, J; Villalba, M | 1 |
| Cox, BM; Jacocks, HM | 1 |
| Cler, JA; Garland, DJ; Hood, WF; Iyengar, S; Mick, SJ; Monahan, JB; Rao, TS; Sun, ET; Vazquez, ML | 1 |
| Gay, VL; Medhamurthy, R; Plant, TM | 1 |
| Patel, J; Salama, AI; Thompson, C; Zinkand, WC | 1 |
| Akaike, N; Kakehata, S; Nakagawa, T; Takasaka, T | 1 |
| Weiland, NG | 1 |
| Cai, Z; McCaslin, PP | 1 |
| Faden, AI; Panter, SS | 1 |
| Buchwald, NA; Cepeda, C; Levine, MS; Peacock, W; Radisavljevic, Z | 1 |
| Erdö, SL; Schäfer, M | 1 |
| Flavin, MP; Riopelle, RJ; Yang, Y | 1 |
| Pinnock, RD | 1 |
| Rekling, JC | 1 |
| Abarca, J; Bradberry, CW; Bustos, G; Forray, MI; Gysling, K; Roth, RH | 1 |
| Chuang, DM; Gao, XM; Paul, SM | 1 |
| Abe, K; Saito, H | 1 |
| Assaf, H; Lust, WD; Ratcheson, RA; Selman, WR; Whittingham, TS | 1 |
| Eigyo, M; Ibii, N; Katsuura, G; Matsushita, A; Shinohara, S; Shintaku, H | 1 |
| Lanius, RA; Shaw, C | 2 |
| Darles, G; Graham, D; Langer, SZ | 1 |
| McCaslin, PP; Yu, XZ | 1 |
| Sekiguchi, M; Wada, K; Wenthold, RJ | 1 |
| Giberti, A; Mugnaini, M; Ratti, E; van Amsterdam, FT | 1 |
| Dingledine, R; Heinemann, SF; Hume, RI | 1 |
| Ebling, FJ; Hastings, MH; Hui, Y; Maywood, ES | 1 |
| Chergui, K; Chouvet, G; Gonon, F; Suaud-Chagny, MF | 1 |
| Hamada, T; Shibata, S; Tominaga, K; Watanabe, S | 1 |
| Avanzini, G; Bugiani, O; Franceschetti, S; Panzica, F | 1 |
| el-Asrar, AM; Maimone, D; Morse, PH; Reder, AT; Torczynski, E | 1 |
| Coyle, JT; Tasker, RC; Vornov, JJ | 2 |
| Feuerstein, TJ; Jackisch, R; Koch, R; Lücking, CH; Lupp, A | 1 |
| Ascher, P; Dieudonné, S; MacDonald, JF; Sather, W | 1 |
| Buchanan, JT; Meer, DP | 1 |
| Chan, J; Greenberg, DA; Lustig, HS; von Brauchitsch, KL | 1 |
| Henry, JL; Hong, Y | 1 |
| Holopainen, I; Janáky, R; Oja, SS; Saransaari, P; Varga, V | 1 |
| Chizhmakov, IV; Jackson, H; Kiskin, NI; Krishtal, OA; Mueller, AL | 1 |
| Marini, AM; Paul, SM; Weller, M | 1 |
| Bowen, DM; Foster, AC; Francis, PT; Middlemiss, DN; Pangalos, MN; Pearson, RC | 1 |
| Cazalets, JR; Clarac, F; Sqalli-Houssaini, Y | 1 |
| Evans, PD; Merzon, RM; Reale, V; Villegas, J | 2 |
| Ehrenberger, K; Felix, D | 1 |
| Costa, E; Kiedrowski, L; Wroblewski, JT | 1 |
| Pittaluga, A; Raiteri, M | 2 |
| Attwell, D; Miller, B; Sarantis, M; Traynelis, SF | 1 |
| Andersen, CF; Frandsen, A; Schousboe, A | 1 |
| Baruah, S; Hegwood, TS; Sherman, AD; Waziri, R | 1 |
| Fain, GL; Yazejian, B | 1 |
| Frandsen, A; Schousboe, A | 1 |
| Martin, D; McNamara, JO; Nadler, JV | 1 |
| Benveniste, H; Hedlund, LW; Johnson, GA | 1 |
| Kawai, N; Nakajima, T; Robinson, HP; Shimazaki, K; Takenawa, T | 1 |
| Balázs, R; Hack, N; Kumar, KN; Michaelis, E; Resink, A; Van der Valk, JB | 1 |
| Artaud, F; Chéramy, A; Desce, JM; Galli, T; Glowinski, J; Godeheu, G | 1 |
| Isacson, O; Sofroniew, MV | 1 |
| Bleakman, D; Chard, PS; Glaum, SR; Miller, RJ; Rusin, KI | 1 |
| Malmberg, AB; Yaksh, TL | 1 |
| Horii, A; Mochizuki, T; Okakura, K; Wada, H; Yamatodani, A | 1 |
| Bonhaus, DW; McNamara, JO | 1 |
| Blazynski, C; Linn, DM; Massey, SC; Redburn, DA | 1 |
| Beal, MF; Finn, SF; Kowall, NW; Mazurek, MF; Swartz, KJ | 1 |
| Hu, B; Johnston, MV; McDonald, JW; Silverstein, FS | 1 |
| Akaike, N; Ito, C; Wakamori, M | 1 |
| Aquila, WJ; Petroff, OA; Yates, J; Young, RS | 1 |
| Katz, LC; Yuste, R | 1 |
| Crane, AM; Driscoll, BF; Law, MJ | 1 |
| Blake, JF; Brown, MW; Collingridge, GL; Frenguelli, BG | 1 |
| Kihara, M; Kubo, T; Misu, Y | 1 |
| Bovolin, P; Costa, E; Grayson, DR; Memo, M | 1 |
| Kemp, JA; Priestley, T | 1 |
| Frye, GD | 1 |
| Bridges, RJ; Cotman, CW; Hatalski, CG; Koh, JY | 1 |
| Jhamandas, K; Ruzicka, BB | 1 |
| Barzizza, A; Maura, G; Raiteri, M | 1 |
| Rosenberg, PA | 1 |
| Nakagawa, S; Nakamura, H; Noda, T; Saheki, T; Yada, T | 1 |
| Chan, J; Greenberg, DA | 1 |
| Dougherty, PM; Willis, WD | 1 |
| Garcia-Ladona, FJ; Girard, C; Gombos, G; Palacios, JM | 1 |
| Shreve, PE; Uretsky, NJ | 1 |
| Hofmann, HD; Huba, R | 1 |
| Beaton, JA; Monaghan, DT | 1 |
| Ben-Ari, Y; Cherubini, E; Ito, S; Krnjević, K | 1 |
| van den Pol, AN | 1 |
| Dreyer, EB; Kaiser, PK; Lipton, SA; Sucher, NJ | 1 |
| Kirsch, JF; Toney, MD | 1 |
| Sapru, H; Sundaram, K | 1 |
| Hatziefthimiou, A; Kouvelas, ED; Mitsacos, A; Mitsaki, E; Plaitakis, A | 1 |
| Carter, AJ; Müller, RE | 1 |
| Chetkovich, DM; Gray, R; Johnston, D; Sweatt, JD | 1 |
| Choi, DW; Koh, JY | 1 |
| Chen, L; Huang, LY | 1 |
| Cline, HT; Constantine-Paton, M; Debski, EA; McDonald, JW | 1 |
| Garyaev, AP; Piotrovsky, LB; Poznyakova, LN | 1 |
| Eysel, UT; FitzGibbon, T; Funke, K | 1 |
| Lei, SZ; Lipton, SA; Sucher, NJ | 1 |
| Lees, GJ; Sandberg, M | 1 |
| Beart, PM; Cincotta, M; Young, NA | 1 |
| Choi, DW; Regan, RF | 1 |
| Delrée, P; Lefebvre, PP; Leprince, P; Moonen, G; Rigo, JM; Rogister, B; Weber, T | 1 |
| Schmidt, M | 1 |
| Bagust, J; Gardner, CR; Hussain, S; Walker, RJ | 1 |
| Oja, SS; Saransaari, P | 2 |
| Dumpis, MA; Kiskin, NI; Krishtal, OA; Piotrovsky, LB | 1 |
| Adams, RN; Cammack, J; Ghasemzadeh, B | 1 |
| Costa, E; de Costa, BR; Di Chiro, G; Ferrarese, C; Fulham, MJ; Guidotti, A; Miletich, RS; Rice, KC | 1 |
| Pellerin, L; Wolfe, LS | 1 |
| Olney, JW; Pathikonda, M; Snider, WD; Stewart, GR | 1 |
| Jean, A; Kessler, JP | 1 |
| Agrawal, AK; Murthy, CR; Rao, VL | 1 |
| Cherubini, E; Kilić, G; Moran, O | 1 |
| Glantz, RM; Pfeiffer-Linn, C | 1 |
| Fukushima, R; Kizu, A; Miyagishi, T; Ono, T; Yoshida, Y | 1 |
| Garthwaite, J; Southam, E | 1 |
| Coulter, DA; DeLorenzo, RJ; Sombati, S | 1 |
| Cai, NS; Erdö, SL; Kiss, B | 1 |
| Batchelor, AM; East, SJ; Garthwaite, J | 1 |
| Billard, JM; Daniel, H; Pumain, R | 1 |
| Fink, K; Göthert, M | 2 |
| Carlsson, A; Carlsson, M | 1 |
| McMillian, M; Miller, LG; Schatzki, A | 1 |
| Larson, AA; Skilling, SR; Smullin, DH | 1 |
| Cline, HT; Tsien, RW | 1 |
| Hećimović, H; Randić, M; Ryu, PD | 1 |
| Mayer, ML | 1 |
| Ly, AM; Michaelis, EK | 1 |
| Kendig, JJ; Savola, MK; Woodley, SJ | 1 |
| Funk, GD; Sholomenko, GN; Steeves, JD | 1 |
| Braquet, P; Chabrier, PE; Demerlé-Pallardy, C; Lonchampt, MO | 1 |
| Lovinger, DM; Weight, FF; White, G | 1 |
| Hoehn, K; White, TD | 1 |
| Fujiwara, M; Fukunaga, R; Kameyama, M; Ninomiya, H; Shimohama, S; Taniguchi, T | 1 |
| Ziskind-Conhaim, L | 1 |
| Compton, RP; Hood, WF; Monahan, JB | 1 |
| Bommarito, M; Johnston, MV; McDonald, JW; Silverstein, FS | 1 |
| Harrison, PH | 1 |
| Dalkara, T; Erdemli, G; Onur, R | 1 |
| Albers, GW | 1 |
| Drapeau, C; Pellerin, L; Rostworowski, K; Wolfe, LS | 1 |
| Glaum, SR; Miller, RJ; Scholz, WK | 1 |
| Cox, JA; Felder, CC; Henneberry, RC | 1 |
| Attwell, D; Sarantis, M | 1 |
| Markram, H; Segal, M | 1 |
| Butterworth, RF; Cotman, CW; Giguere, JF; Peterson, C | 1 |
| Clements, JD; Jahr, CE; Lester, RA; Westbrook, GL | 1 |
| Nistri, A; Sivilotti, L; Welsh, DM | 1 |
| Choi, DW | 1 |
| Bockaert, J; Dumuis, A; Oomagari, K; Pin, JP; Sebben, M | 1 |
| Becquet, D; Faudon, M; Hery, F | 1 |
| Britt, M; Chapdelaine, MJ; Keith, RA; LaMonte, D; Mangano, TJ; Patel, J; Powel, RJ; Pullan, LM; Stumpo, RJ; Warwick, PJ | 1 |
| Hestrin, S; Nicoll, RA; Sah, P | 2 |
| Ohe, Y; Pan-Hou, H; Suda, Y; Sumi, M; Yoshioka, M | 1 |
| DiFiglia, M; Freese, A; Koroshetz, WJ | 1 |
| Eremjan, HH; Motin, LG; Sokolova, SN; Uteshev, VV; Zilberter, YI | 1 |
| Kurozumi, K; Murayama, T; Nomura, Y | 1 |
| Kendall, DA; Robinson, JP | 1 |
| Baron, BM; McDonald, IA; Miller, F; Muench, D; White, HS; Whitten, JP | 1 |
| Drewe, JA; Kunze, DL; Miles, R | 1 |
| Dudek, FE; van den Pol, AN; Wuarin, JP | 1 |
| Buso, M; Facci, L; Leon, A; Milani, D; Skaper, SD; Toffano, G | 1 |
| Bockaert, J; Didier, M; Heaulme, M; Pin, JP; Soubrié, P | 1 |
| Erdö, SL; Michler, A; Tytko, H; Wolff, JR | 1 |
| Heinemann, U; Mudrick, LA | 1 |
| Bridges, RJ; Caiozzo, VJ; Gardner, VO; Munden, SK | 1 |
| Nicholson, C; Rice, ME | 1 |
| MacDonald, MC; Wilkinson, M | 1 |
| Brodfuehrer, PD; Cohen, AH | 1 |
| Enomoto, R; Ogita, K; Ping, ZP; Suzuki, T; Yoneda, Y | 1 |
| McMillian, M; Miller, LG; Pritchard, GA | 1 |
| Boos, R; Müller, F; Wässle, H | 1 |
| Chalmers, DT; Dewar, D; Graham, DI; McCulloch, J; Shand, A | 1 |
| Catalin, D; Cherkaoui, N; Jean, A; Kessler, JP | 1 |
| Collingridge, GL; Davies, SN | 1 |
| Sansom, MS; Usherwood, PN | 1 |
| Cordi, AA; Monahan, JB; Reisse, J | 1 |
| Dauth, GW; Gilman, S; Hollingsworth, Z; Kaatz, K; Penney, JB; Young, AB | 1 |
| Khaspekov, LG; Lisý, V; Stastný, F; Viktorov, IV | 1 |
| Baraldi, PG; Beani, L; Bianchi, C; Manfredini, S; Pollini, GP | 1 |
| Jean, A; Tell, F | 1 |
| Baraban, JM; Murphy, TH | 1 |
| Michl, J; Ujec, E; Vlachová, V; Vyklický, L; Vyskocil, F | 1 |
| Aanonsen, LM; Wilcox, GL | 1 |
| Jordan, W; Sutor, B; Zieglgänsberger, W | 1 |
| Cherubini, E; King, AE; Nistri, A | 1 |
| MacDonald, JF; Miljkovic, Z; Pennefather, P | 1 |
| Connor, JA; Hockberger, PE; Wadman, WJ; Wong, RK | 1 |
| Colquhoun, D; Cull-Candy, SG; Howe, JR | 1 |
| DeLander, GE; Wahl, JJ | 1 |
| Cull-Candy, SG; Howe, JR; Ogden, DC | 1 |
| Cull-Candy, SG; Gallo, V; Usowicz, MM | 1 |
| Murase, K; Randic, M; Ryu, PD | 1 |
| Copenhagen, DR; Jahr, CE | 1 |
| Heinemann, S; Hollmann, M; O'Shea-Greenfield, A; Rogers, SW | 1 |
| Fonnum, F; Syvertsen, C | 1 |
| Araneda, R; Bustos, G | 1 |
| Clow, DW; Jhamandas, K | 1 |
| O'Dell, TJ | 1 |
| Kawai, N; Miwa, A; Nakajima, T; Sahara, Y; Saito, M; Shimazaki, K | 1 |
| Harris, KM; Miller, RJ | 1 |
| Westerberg, E; Wieloch, TW | 1 |
| Ogita, K; Yoneda, Y | 5 |
| Daly, MP; Demediuk, P; Faden, AI | 1 |
| Miller, RJ; Murphy, SN | 1 |
| Guiramand, J; Nourigat, A; Recasens, M; Sassetti, I | 1 |
| Albers, GW; Choi, DW; Goldberg, MP | 1 |
| Oertel, D; Wickesberg, RE | 1 |
| Brewer, GJ; Cotman, CW | 1 |
| Demediuk, P; Faden, AI; Panter, SS; Vink, R | 1 |
| Meguri, H; Ogita, K; Ohgaki, T; Uchida, S; Yoneda, Y | 1 |
| Baba, A; Iwata, H; Kihara, T; Sawada, T | 1 |
| Beart, PM; Cincotta, M; Summers, RJ | 1 |
| King, AE; Thompson, SW | 1 |
| Bowen, DM; Hutson, PH; Lowe, SL; Palmer, AM | 1 |
| Costa, E; Favaron, M; Guidotti, A; Manev, H | 1 |
| Ben-Ari, Y; Represa, A; Tremblay, E | 1 |
| Crépel, F; Hicks, TP; Krupa, M | 1 |
| Guiramand, J; Recasens, M; Sassetti, I | 1 |
| Canonico, PL; Nicoletti, F | 1 |
| Choi, DW; Hartley, DM | 2 |
| Belhage, B; Bouchelouche, P; Drejer, J; Frandsen, A; Schousboe, A | 1 |
| Caspary, DM; Faingold, CL; Hoffmann, WE | 1 |
| Astier, H; Tapia-Arancibia, L | 2 |
| Beani, L; Bianchi, C; Jope, RS; Simonato, M | 1 |
| Herranz, AS; Herreras, O; Martín del Río, R; Menéndez, N; Solis, JM | 1 |
| Johnson, KM; Jones, SM | 1 |
| Gerber, G; Kangrga, I; Larew, JS; Randic, M; Ryu, PD | 1 |
| Anis, NA; Eldefrawi, AT; Eldefrawi, ME; Gant, DB; Konno, K; Miledi, R; Ragsdale, D | 1 |
| Busija, DW; Leffler, CW | 1 |
| Sawyer, BD; Shannon, HE | 1 |
| Itzhak, Y | 1 |
| Dye, J; Heiligenberg, W; Kawasaki, M; Keller, CH | 1 |
| Bredt, DS; Snyder, SH | 1 |
| Bear, MF; Dudek, SM | 1 |
| Cooper, SM; Cotman, CW; Geddes, JW; Meldrum, BS; Patel, S | 1 |
| Hornfeldt, CS; Larson, AA | 1 |
| Brunori, A; Mayer, ML; Sugiyama, K | 1 |
| Bockaert, J; Didier, M; Piechaczyk, M; Pin, JP; Roux, P; Verrier, B | 1 |
| Gallagher, JP; Hasuo, H | 1 |
| Arenson, MS; Nistri, A | 1 |
| Mayer, ML; Westbrook, GL | 3 |
| Arenson, MS; King, A; Nistri, A | 1 |
| Harrison, NL; Simmonds, MA | 1 |
| Bloomfield, SA; Dowling, JE | 1 |
| Galton, N; Michaelis, E; Roy, S | 1 |
| Beart, PM; Bridge, S; Christie, MJ; James, LB | 1 |
| Christensen, BN; Hals, G; Shingai, R | 1 |
| Collins, JF; Meldrum, BS; Turski, L | 1 |
| Harris, RA | 1 |
| Labruyere, J; Olney, JW; Price, MT; Samson, L | 1 |
| Cohen, A; Erez, U; Frenk, H; Goldberg, O; Teichberg, VI | 1 |
| Kimura, H; Okamoto, K; Sakai, Y | 1 |
| Jahr, CE; Jessell, TM | 1 |
| Cotman, CW; Monaghan, DT; Yao, D | 1 |
| Homma, S | 1 |
| Gray, PN; May, PC | 1 |
| Cotman, CW; Monaghan, DT | 1 |
| Goldberg, O; Teichberg, VI | 2 |
| Davies, J; Quinlan, JE | 1 |
| Murali Mohan, P; Sastry, BR | 1 |
| Brodin, L; Grillner, S | 1 |
| Cotman, CW; Ganong, AH | 1 |
| Hablitz, JJ | 2 |
| Baudry, M; Cummins, JT; Kessler, M; Lynch, G; Way, S | 1 |
| Beart, PM; Christie, MJ; James, LB | 1 |
| Masui, H; Sato, H; Tsumoto, T | 1 |
| Thomson, AM | 2 |
| Addae, JI; Stone, TW | 1 |
| Ariel, M; Dowling, JE; Mangel, SC | 1 |
| Drejer, J; Honoré, T; Meier, E; Schousboe, A | 1 |
| Jürgens, U; Richter, K | 1 |
| Franchi-Micheli, S; Luzzi, S; Moroni, F; Zilletti, L | 1 |
| Gale, K; Piredda, S | 1 |
| Carpenter, DO; ffrench-Mullen, JM; Hori, N | 1 |
| Crepel, F; Gardette, R | 1 |
| Bobbin, RP; Jenison, GL; Winbery, S | 1 |
| Feldman, JL; McCrimmon, DR; Speck, DF | 1 |
| Johnson, KM; Snell, LD | 1 |
| Choi, DW; Koh, JY; Peters, S | 2 |
| Cotman, CW; Ganong, AH; Harris, EW; Monaghan, DT; Watkins, JC | 1 |
| Cotman, CW; Geddes, JW | 1 |
| Garthwaite, G; Garthwaite, J | 2 |
| D'Amato, CJ; Greenamyre, JT; Penney, JB; Young, AB | 1 |
| Costa, E; Nicoletti, F; Wroblewski, JT | 1 |
| Gordon, FJ | 1 |
| Fagg, GE; Foster, AC | 1 |
| Bennett, DA; Bernard, P; Boehm, C; Lehmann, J; McPherson, S; Murphy, DE; Pastor, G; Schneider, J; Steel, DJ; Tsai, C | 1 |
| Michel, J; Monahan, JB | 1 |
| Ito, K; Izumi, Y; Kato, H; Kudo, Y; Miyakawa, H; Ogura, A | 1 |
| Davies, SW; Roberts, PJ | 1 |
| Anderton, PJ; Normann, RA; Perlman, I | 1 |
| Foster, AC; Wong, EH | 1 |
| Lehmann, A | 1 |
| Crepel, F; Dupont, JL; Gardette, R | 2 |
| Compton, RP; Hood, WF; Michel, J; Monahan, JB; Olney, JW; Price, MT; Pullan, LM | 1 |
| Crunelli, V; Kelly, JS; Leresche, N; Pirchio, M | 1 |
| Durand, J; Engberg, I; Tyc-Dumont, S | 1 |
| Samanin, R; Vezzani, A; Wu, HQ | 1 |
| Cotman, CW; Harris, EW; Stevens, DR | 1 |
| Grantyn, R; Hablitz, JJ; Lux, HD; Perouansky, M | 1 |
| Breese, GR; Givens, BS; McCown, TJ | 1 |
| Greenamyre, JT; Olson, JM; Penney, JB; Young, AB | 1 |
| Alho, H; Costa, E; Eva, C; Fadda, E; Nicoletti, F; Wroblewski, JT | 1 |
| Frierdich, G; Labruyere, J; Mahan, K; Olney, JW; Price, MT; Ryerson, R; Salles, KS; Samson, L | 1 |
| Cuénod, M; Knöpfel, T; Zeise, ML; Zieglgänsberger, W | 1 |
| Crepel, F; Gardette, R; Krupa, M | 1 |
| Burton, NR; Williams, TL | 1 |
| Dryer, SE | 1 |
| Walker, JB; Woznicki, DT | 1 |
| Nishizaki, T; Okada, Y; Yamauchi, R | 1 |
| Engberg, I; Flatman, JA; Nedergaard, S | 1 |
| Ambar, I; Kloog, Y; Sokolovsky, M | 1 |
| Baba, A; Iwata, H; Nishiuchi, Y; Tatsuno, T; Uemura, A | 1 |
| Hutchison, AJ; Lehmann, J; McPherson, SE; Mondadori, C; Murphy, DE; Schmutz, M; Sinton, CM; Steel, DJ; Tsai, C; Williams, M | 1 |
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| Basak, S; Bowen, ME; Choi, UB; Ding, F; Kwun, D; Saikia, N | 1 |
| Curic, S; Haaf, M; Leicht, G; Mulert, C; Rauh, J; Steinmann, S | 1 |
| Carlson, M; Choo, TH; De Baun, HM; Dias, E; Gangwisch, J; Girgis, RR; Iosifescu, DV; Kantrowitz, JT; Kegeles, LS; Mayer, MR; Medalia, A; Saperstein, AM; Sehatpour, P; Shope, C; Sobeih, T; Wall, MM | 1 |
| Dariyerli, N; Ekiz-Yilmaz, T; Guner, I; Meydanlı, EEG; Sahin, G; Sönmez, D; Sönmez, OF; Yaman, MO; Yelmen, N | 1 |
| Hajdú, T | 1 |
| Alaei, H; Amohashemi, E; Reisi, P | 1 |
| Burnat, G; Cieślik, P; Kalinowski, L; Wierońska, JM | 1 |
| Amirsadri, M; Esfahani, NMJ; Esmaeili, F; Hoseini, SJ; Keimasi, M; Mofid, MR; Moradmand, M; Salehifard, K | 1 |
| Fu, JJ; Li, C; Li, XH; Luo, ZQ; Shao, M; Shi, XJ; Yue, SJ; Zhang, YN | 1 |
| Li, CH; Liu, YZ | 1 |
| Liu, M; Tuo, J; Xu, Z; Yu, C; Zhang, F; Zhang, J; Zhang, L | 1 |
| Gipson, CD; Hong, M; Khatri, SN; Maher, EE; Sadek, S; Stoops, WW; Ulangkaya, H; Woodcox, AM | 1 |
| Gardier, AM; Guilloux, JP; Nguyen, TML | 1 |
70 review(s) available for n-methylaspartate and glutamic acid
| Article | Year |
|---|---|
Ligands for glutamate receptors: design and therapeutic prospects.
Topics: Animals; Drug Design; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Ligands; N-Methylaspartate; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Synapses | 2000 |
Do NMDA antagonists prevent neuronal injury? No.
Topics: Animals; Brain; Brain Diseases; Brain Ischemia; Cell Death; Glutamates; Glutamic Acid; Hypoxia, Brain; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate | 1992 |
Interactions between glutamatergic and monoaminergic systems within the basal ganglia--implications for schizophrenia and Parkinson's disease.
Topics: Animals; Anticonvulsants; Aspartic Acid; Basal Ganglia; Biogenic Amines; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Humans; N-Methylaspartate; Parkinson Disease; Schizophrenia | 1990 |
Alcohol inhibition of NMDA channel function.
Topics: Alcohols; Animals; Brain; Cell Membrane; Ethanol; Evoked Potentials; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate | 1991 |
Potential therapeutic uses of N-methyl-D-aspartate antagonists in cerebral ischemia.
Topics: Aspartic Acid; Brain Ischemia; Glutamates; Glutamic Acid; Humans; Models, Biological; N-Methylaspartate; Nervous System; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Formation of 12-lipoxygenase metabolites in rat cerebral cortical slices: stimulation by calcium ionophore, glutamate and N-methyl-D-aspartate.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonate 12-Lipoxygenase; Arachidonate Lipoxygenases; Aspartic Acid; Calcimycin; Cerebral Cortex; Glutamates; Glutamic Acid; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; N-Methylaspartate; Neurotransmitter Agents; Phorbol Esters | 1990 |
Cerebral hypoxia: some new approaches and unanswered questions.
Topics: Animals; Aspartic Acid; Brain Diseases; Cell Survival; Cerebrovascular Circulation; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Hypoxia; N-Methylaspartate; Neuroglia; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Quinoxalinediones as excitatory amino acid antagonists in the vertebrate central nervous system.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Binding, Competitive; Central Nervous System; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Membrane Potentials; N-Methylaspartate; Quinoxalines; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Signal Transduction; Spinal Cord; Structure-Activity Relationship; Vertebrates | 1990 |
Single-channel studies of glutamate receptors.
Topics: Animals; Anions; Astacoidea; Cations, Divalent; Electrophysiology; Glutamates; Glutamic Acid; Glycine; Grasshoppers; Hippocampus; Ibotenic Acid; Invertebrates; Ion Channel Gating; Kainic Acid; Membrane Potentials; Models, Biological; N-Methylaspartate; Neuromuscular Junction; Neurotransmitter Agents; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship; Synaptic Transmission; Vertebrates | 1990 |
N-methyl-D-aspartate antagonists: ready for clinical trial in brain ischemia?
Topics: Aspartic Acid; Brain; Brain Ischemia; Clinical Trials as Topic; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Models, Neurological; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1989 |
Excitatory amino acid transmitters in neuronal circuits of the cat visual cortex.
Topics: Acetylcholine; Animals; Aspartic Acid; Cats; Dipeptides; Evoked Potentials, Visual; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Neurons; Neurotransmitter Agents; Pipecolic Acids; Receptors, Amino Acid; Receptors, Cell Surface; Visual Cortex | 1986 |
The physiology of excitatory amino acids in the vertebrate central nervous system.
Topics: Amino Acids; Animals; Aspartic Acid; Central Nervous System; Glutamates; Glutamic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Vertebrates | 1987 |
Excitatory receptors and their role in excitotoxicity.
Topics: Aminobutyrates; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Humans; N-Methylaspartate; Neurons; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
On the excitatory post-synaptic potential evoked by stimulation of the optic tract in the rat lateral geniculate nucleus.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Aminobutyrates; Animals; Aspartic Acid; Calcium; Dipeptides; Glutamates; Glutamic Acid; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Optic Nerve; Rats; Rats, Inbred Strains; Synapses; Thalamic Nuclei; Valine | 1987 |
The stimulation of ion fluxes in brain slices by glutamate and other excitatory amino acids.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Biological Transport, Active; Brain; Calcium; Cations; Cell Membrane Permeability; Glutamates; Glutamic Acid; In Vitro Techniques; Ion Channels; Kainic Acid; Kinetics; N-Methylaspartate; Potassium; Rubidium; Sodium; Sodium-Potassium-Exchanging ATPase | 1981 |
Nitric oxide: cellular regulation and neuronal injury.
Topics: Amino Acid Oxidoreductases; DNA Damage; Enzyme Activation; Free Radicals; Glutamic Acid; Humans; Models, Neurological; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nitric Oxide; Nitric Oxide Synthase; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Receptors, N-Methyl-D-Aspartate; Tacrolimus | 1994 |
New mechanisms of excitatory transmitter neurotoxicity.
Topics: Acetylcholine; Animals; Glutamic Acid; Humans; N-Methylaspartate; Nervous System Diseases; Neurotoxins; Receptors, Amino Acid; Receptors, Metabotropic Glutamate; Syndrome | 1994 |
Excitatory amino acids as a final common pathway for neurologic disorders.
Topics: Biological Transport; Brain Diseases; Calcium; Glutamates; Glutamic Acid; Humans; N-Methylaspartate; Neurons; Receptors, Glutamate | 1994 |
Pathophysiology of the migraine aura. The spreading depression theory.
Topics: Cerebral Cortex; Cerebrovascular Circulation; Cortical Spreading Depression; Glutamates; Glutamic Acid; Humans; Ischemic Attack, Transient; Migraine Disorders; N-Methylaspartate | 1994 |
The role of glutamate in epilepsy and other CNS disorders.
Topics: Animals; Central Nervous System Diseases; Epilepsy; Glutamic Acid; Humans; Lamotrigine; Mice; N-Methylaspartate; Parkinson Disease; Piperazines; Pyrimidines; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Sodium Channels; Triazines | 1994 |
Glutamatergic treatment strategies for age-related memory disorders.
Topics: Acetamides; Aging; Animals; Cognition; Cycloserine; Glutamic Acid; Humans; Memory Disorders; N-Methylaspartate; Nootropic Agents; Receptors, N-Methyl-D-Aspartate | 1994 |
Calcium and glutamate-induced cortical neuronal death.
Topics: Animals; Calcium; Cell Death; Cerebral Cortex; Glutamates; Glutamic Acid; Models, Neurological; N-Methylaspartate; Neurons; Neurotoxins; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1993 |
The sodium-calcium exchanger and glutamate-induced calcium loads in aged hippocampal neurons in vitro.
Topics: Aging; Animals; Calcium; Carrier Proteins; Cells, Cultured; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Rats; Sodium; Sodium-Calcium Exchanger | 1996 |
The role of glutamate in behavioral and neurotoxic effects of methamphetamine.
Topics: Animals; Behavior, Animal; Brain Chemistry; Central Nervous System Stimulants; Excitatory Amino Acid Antagonists; Glutamic Acid; Methamphetamine; N-Methylaspartate; Rats | 1996 |
Glutamatergic transmission in the nucleus tractus solitarii: from server to peripherals in the cardiovascular information superhighway.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Baroreflex; Cardiovascular Physiological Phenomena; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Kainic Acid; N-Methylaspartate; Receptors, Glutamate; Solitary Nucleus | 1997 |
Behavioral approaches to the functional assessment of NMDA-mediated neural transmission in intact mice.
Topics: Animals; Behavior, Animal; Glutamic Acid; Humans; Mice; Mice, Inbred Strains; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1997 |
Excitotoxic mechanisms of neurodegeneration in transmissible spongiform encephalopathies.
Topics: Animals; Brain; Cricetinae; Glutamic Acid; Humans; Hypothalamus; Ibogaine; Kainic Acid; Mice; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Prion Diseases | 1997 |
Toward the development of strategies to prevent ischemic neuronal injury. In vitro studies.
Topics: Animals; Apoptosis; Brain Ischemia; Cell Death; Cerebellum; Fibroblast Growth Factor 2; Glutamic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Receptors, N-Methyl-D-Aspartate; Transcription, Genetic | 1997 |
Release and uptake of glutamate as related to excitotoxicity.
Topics: 4-Aminopyridine; Cell Culture Techniques; Glutamic Acid; N-Methylaspartate; Nerve Degeneration | 1996 |
Molecular basis of glutamate toxicity in retinal ganglion cells.
Topics: Animals; Calcium; Cell Death; Feedback; Glutamic Acid; N-Methylaspartate; Neurotoxins; Rats; Retinal Ganglion Cells; Second Messenger Systems | 1997 |
A proposed role for excitotoxicity in glaucoma.
Topics: Animals; Glaucoma; Glutamic Acid; Humans; N-Methylaspartate; Retinal Ganglion Cells; Vitreous Body | 1998 |
Cognitive deficit in schizophrenia and its neurochemical basis.
Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Cognition Disorders; Glutamic Acid; Haloperidol; Humans; N-Methylaspartate; Olanzapine; Pirenzepine; Risperidone; Schizophrenia; Schizophrenic Psychology | 1999 |
The role of excitotoxicity in neurodegenerative disease: implications for therapy.
Topics: AIDS Dementia Complex; Amyotrophic Lateral Sclerosis; Calcium; Excitatory Amino Acids; Glutamic Acid; Humans; N-Methylaspartate; Neurodegenerative Diseases; Neurotransmitter Agents | 1999 |
An experimental basis for implicating excitotoxicity in glaucomatous optic neuropathy.
Topics: Animals; Apoptosis; Enzyme Inhibitors; Glaucoma; Glutamic Acid; Humans; Intraocular Pressure; N-Methylaspartate; Neuroprotective Agents; Nitric Oxide Synthase; Optic Nerve Diseases; Retinal Ganglion Cells; Vitreous Body | 1999 |
The role of amino acid neurotransmitters in the regulation of pituitary gonadotropin release in fish.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Female; Fishes; gamma-Aminobutyric Acid; Glutamic Acid; Gonadotropins, Pituitary; Luteinizing Hormone; Male; Models, Biological; N-Methylaspartate; Neurotransmitter Agents; Phylogeny; Sex Factors | 2000 |
l-glutamate as a central neurotransmitter: looking back.
Topics: Animals; Brain; Glutamic Acid; History, 20th Century; Humans; Models, Biological; Models, Chemical; N-Methylaspartate; Neurotransmitter Agents; Receptors, Glutamate; Structure-Activity Relationship; Synapses | 2000 |
Physiological relevance of endogenous free D-serine in the mammalian brain: are scientists on a royal road for the treatment of glutamatergic-related brain disorders?
Topics: Animals; Astrocytes; Brain Chemistry; Glutamic Acid; Humans; N-Methylaspartate; Neurodegenerative Diseases; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission | 2001 |
Role of excitatory amino acids in developmental epilepsies.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Epilepsy; Excitatory Amino Acids; Glutamic Acid; Humans; Kinetics; N-Methylaspartate; Synaptic Transmission | 2001 |
Glutamate antagonists limit tumor growth.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antineoplastic Agents; Cell Division; Cell Movement; Drug Synergism; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; N-Methylaspartate; Tumor Cells, Cultured | 2002 |
Excitatory amino acids.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acids; Glutamic Acid; Humans; N-Methylaspartate; Receptors, Glutamate; Receptors, Metabotropic Glutamate | 2002 |
The paraventricular nucleus: an important component of the central neurocircuitry regulating sympathetic nerve outflow.
Topics: Action Potentials; Animals; Bicuculline; Blood Pressure; Glutamic Acid; Heart Rate; Homeostasis; Humans; Kidney; N-Methylaspartate; Neurons, Efferent; Nitric Oxide Synthase; Paraventricular Hypothalamic Nucleus; Receptors, GABA; Spleen; Sympathetic Nervous System | 2003 |
N-methyl-D-aspartate and TrkB receptor activation in cerebellar granule cells: an in vitro model of preconditioning to stimulate intrinsic survival pathways in neurons.
Topics: Animals; Autocrine Communication; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebellum; Genes, bcl-2; Glutamic Acid; Ischemic Preconditioning; N-Methylaspartate; Neurons; Neuroprotective Agents; NF-kappa B; Oligonucleotides, Antisense; Receptor, trkB; Receptors, N-Methyl-D-Aspartate | 2003 |
Glutamate and the glutamate receptor system: a target for drug action.
Topics: Alzheimer Disease; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; N-Methylaspartate; Neuroprotective Agents; Receptors, Glutamate; Synaptic Transmission | 2003 |
Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury.
Topics: Animals; Brain Injuries; Brain Ischemia; Glutamic Acid; Humans; N-Methylaspartate; Nerve Degeneration; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2004 |
Structural plasticity and tianeptine: cellular and molecular targets.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antidepressive Agents, Tricyclic; Apoptosis; Atrophy; Dentate Gyrus; Depressive Disorder, Major; Glutamic Acid; Hippocampus; Humans; N-Methylaspartate; Neuronal Plasticity; Neurons; Serotonin; Thiazepines | 2002 |
Fetal alcohol syndrome at the cellular level.
Topics: Brain; Female; Fetal Alcohol Spectrum Disorders; Glutamic Acid; Humans; N-Methylaspartate; Pregnancy; Receptors, GABA-A | 2004 |
The effects of seizures on the connectivity and circuitry of the developing brain.
Topics: Brain; Child; Developmental Disabilities; Glutamic Acid; Humans; N-Methylaspartate; Nerve Net; Neuronal Plasticity; Seizures; Synapses; Synaptic Transmission | 2004 |
Mechanisms of action of second generation antipsychotic drugs in schizophrenia: insights from brain imaging studies.
Topics: Antipsychotic Agents; Brain; Dopamine; Glutamic Acid; Humans; N-Methylaspartate; Positron-Emission Tomography; Receptors, Dopamine D1; Schizophrenia; Tomography, Emission-Computed, Single-Photon | 2005 |
Neuropathology in Alzheimer's disease: target of pharmacotherapy.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cholinesterase Inhibitors; Disease Progression; Estrogens; Glutamic Acid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; N-Methylaspartate; Neurofibrillary Tangles; Neuropharmacology; Neurotransmitter Agents | 2005 |
Synaptic plasticity and dysconnection in schizophrenia.
Topics: Acetylcholine; Brain; Brain Mapping; Contingent Negative Variation; Dopamine; Electroencephalography; Glutamic Acid; Humans; Models, Neurological; N-Methylaspartate; Nerve Fibers; Nerve Net; Neuronal Plasticity; Schizophrenia; Synapses | 2006 |
What have we learned from proton magnetic resonance spectroscopy about schizophrenia? A critical update.
Topics: Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Cross-Over Studies; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; N-Methylaspartate; Neurons; Protons; Schizophrenia; Temporal Lobe | 2006 |
Where do you think you are going? The NMDA-D1 receptor trap.
Topics: Allosteric Regulation; Animals; Antipsychotic Agents; Calcium; Corpus Striatum; Diffusion; Dopamine; Drug Design; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Mental Disorders; Models, Neurological; N-Methylaspartate; Nervous System Diseases; Neurons; Organ Culture Techniques; Protein Interaction Mapping; Protein Subunits; Protein Transport; Rats; Receptors, Dopamine D1; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synaptic Membranes | 2006 |
Preconditioning and neurotrophins: a model for brain adaptation to seizures, ischemia and other stressful stimuli.
Topics: Adaptation, Physiological; Animals; Brain-Derived Neurotrophic Factor; Calcium; Calcium Signaling; Glutamic Acid; Humans; Hypoxia-Ischemia, Brain; Ischemic Preconditioning; Learning; Memory; N-Methylaspartate; Neurons; NF-kappa B; Receptors, N-Methyl-D-Aspartate; Seizures | 2007 |
Mechanisms involved in the cerebrovascular dilator effects of N-methyl-d-aspartate in cerebral cortex.
Topics: Animals; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulation; Cortical Spreading Depression; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Vasodilation | 2007 |
The cholinergic system, sigma-1 receptors and cognition.
Topics: Acetylcholine; Aging; Animals; Brain; Calcium; Cell Differentiation; Cholinergic Fibers; Cognition; Disease Models, Animal; Glutamic Acid; Humans; N-Methylaspartate; Neurodegenerative Diseases; Neuronal Plasticity; Neurons; Psychotropic Drugs; Receptors, sigma; Sigma-1 Receptor | 2011 |
Dimethyl sulfoxide as an excitatory modulator and its possible role in cancer pain management.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Dimethyl Sulfoxide; Glutamic Acid; Humans; N-Methylaspartate; Neoplasms; Pain, Intractable; Quality of Life; Sodium Channels | 2010 |
NMDA receptors: recent insights and clinical correlations.
Topics: Animals; Calcium; Cell Survival; Central Nervous System; Glutamic Acid; Humans; Ion Channel Gating; Ion Channels; N-Methylaspartate; Nerve Net; Nervous System Diseases; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate | 2011 |
Cell signaling in NMDA preconditioning and neuroprotection in convulsions induced by quinolinic acid.
Topics: Animals; Brain; Brain Chemistry; Cerebrovascular Circulation; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Ischemic Preconditioning; N-Methylaspartate; Neuroprotective Agents; Neurotoxicity Syndromes; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Seizures; Signal Transduction | 2011 |
A role for tumor necrosis factor-α in ischemia and ischemic preconditioning.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Brain Ischemia; Glutamic Acid; Humans; Ischemic Preconditioning; N-Methylaspartate; Neurons; Receptors, Tumor Necrosis Factor; Signal Transduction; Tumor Necrosis Factor-alpha | 2011 |
Mitochondrial uncoupling protein-2 in glutamate neurotoxicity.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Infarction; Ethanol; Glutamic Acid; Hippocampus; Humans; Ion Channels; Mice; Mitochondria; Mitochondrial Proteins; N-Methylaspartate; Neurons; Uncoupling Protein 2 | 2013 |
Attention deficit hyperactivity disorder and N-methyl-D-aspartate (NMDA) dysregulation.
Topics: Adolescent; Adult; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Drug Design; Glutamic Acid; Glycine; Humans; Impulsive Behavior; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate | 2014 |
Targeting the glutamatergic system to treat pathological gambling: current evidence and future perspectives.
Topics: Behavior, Addictive; Dopamine; Excitatory Amino Acid Agents; Gambling; Glutamic Acid; Humans; Male; Molecular Targeted Therapy; N-Methylaspartate; Synaptic Transmission | 2014 |
The metabolic response to excitotoxicity - lessons from single-cell imaging.
Topics: Adenosine Triphosphate; Animals; Calcium Signaling; Glutamic Acid; Humans; Mitochondria; Molecular Imaging; N-Methylaspartate; Neurons; Receptors, AMPA | 2015 |
Role of calcium, glutamate and NMDA in major depression and therapeutic application.
Topics: Animals; Antidepressive Agents; Calcium; Depressive Disorder, Major; Glutamic Acid; Humans; N-Methylaspartate; Neurogenesis; Neuronal Plasticity; Neurotransmitter Agents | 2016 |
The Glutamatergic System in Primary Somatosensory Neurons and Its Involvement in Sensory Input-Dependent Plasticity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ganglia, Sensory; Glutamic Acid; Humans; Kainic Acid; N-Methylaspartate; Neuralgia; Neuronal Plasticity; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Sensory Receptor Cells; Synaptic Transmission | 2017 |
Memantine in neurological disorders - schizophrenia and depression.
Topics: Alzheimer Disease; Antidepressive Agents; Antipsychotic Agents; Clinical Trials as Topic; Depression; Drug Repositioning; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; N-Methylaspartate; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serotonin 5-HT3 Receptor Antagonists | 2021 |
Glutamate modulation for the treatment of levodopa induced dyskinesia: a brief review of the drugs tested in the clinic.
Topics: Antiparkinson Agents; Dyskinesia, Drug-Induced; Glutamic Acid; Humans; Levodopa; N-Methylaspartate; Parkinson Disease | 2022 |
Glutamatergic dysfunction in Schizophrenia.
Topics: Dopamine; Glutamic Acid; Humans; Ketamine; N-Methylaspartate; Schizophrenia | 2022 |
Levodopa-induced dyskinesia: interplay between the N-methyl-D-aspartic acid receptor and neuroinflammation.
Topics: Aged; Dyskinesia, Drug-Induced; Glutamic Acid; Humans; Levodopa; Middle Aged; N-Methylaspartate; Neuroinflammatory Diseases; Parkinson Disease; Quality of Life; Receptors, N-Methyl-D-Aspartate | 2023 |
[Ketamine: a neuropsychotropic drug with an innovative mechanism of action].
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Glutamic Acid; Ketamine; N-Methylaspartate; Pharmaceutical Preparations; Receptors, AMPA | 2023 |
4 trial(s) available for n-methylaspartate and glutamic acid
| Article | Year |
|---|---|
N-methyl-D-aspartate antagonists: ready for clinical trial in brain ischemia?
Topics: Aspartic Acid; Brain; Brain Ischemia; Clinical Trials as Topic; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Models, Neurological; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1989 |
Aspartate and glutamate modulation of growth hormone secretion in the pig: possible site of action.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Aspartic Acid; Body Weight; Cells, Cultured; Dose-Response Relationship, Drug; Female; Glutamic Acid; Growth Hormone; Growth Hormone-Releasing Hormone; N-Methylaspartate; Ovariectomy; Pituitary Gland, Anterior; Serum Albumin; Swine | 1996 |
Glutamatergic Signaling Drives Ketamine-Mediated Response in Depression: Evidence from Dynamic Causal Modeling.
Topics: Adolescent; Adult; Affect; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antidepressive Agents; Brain; Cross-Over Studies; Depressive Disorder, Major; Double-Blind Method; Evoked Potentials, Somatosensory; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Infusions, Intravenous; Ketamine; Magnetoencephalography; Male; Middle Aged; Models, Neurological; N-Methylaspartate; Time Factors; Treatment Outcome; Young Adult | 2018 |
Dose-Dependent Augmentation of Neuroplasticity-Based Auditory Learning in Schizophrenia: A Double-Blind, Placebo-Controlled, Randomized, Target Engagement Clinical Trial of the NMDA Glutamate Receptor Agonist d-serine.
Topics: Antipsychotic Agents; Double-Blind Method; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; N-Methylaspartate; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine | 2023 |
1667 other study(ies) available for n-methylaspartate and glutamic acid
| Article | Year |
|---|---|
DL-tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy.
Topics: Animals; Cell Membrane; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Hippocampus; Molecular Structure; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tetrazoles | 1992 |
New and versatile approaches to the synthesis of CPP-related competitive NMDA antagonists. Preliminary structure-activity relationships and pharmacological evaluation.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Chemical Phenomena; Chemistry, Physical; In Vitro Techniques; N-Methylaspartate; Piperazines; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Synaptic Membranes | 1990 |
Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.
Topics: Animals; Bridged Bicyclo Compounds; Calcium; Cells, Cultured; Cerebellum; CHO Cells; Cricetinae; Cyclic AMP; Cycloleucine; Dicarboxylic Acids; Excitatory Amino Acid Agonists; Glutamic Acid; Inositol Phosphates; Kidney; Ligands; Models, Molecular; Molecular Conformation; Norbornanes; Rats; Receptors, Metabotropic Glutamate; Stereoisomerism | 1998 |
Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists.
Topics: Animals; Cerebral Cortex; Convulsants; Excitatory Amino Acid Agonists; In Vitro Techniques; Isoxazoles; Male; Mice; Mice, Inbred DBA; Models, Molecular; Molecular Conformation; Proline; Pyrroles; Radioligand Assay; Rats; Receptors, AMPA; Receptors, Kainic Acid; Stereoisomerism | 1999 |
N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands.
Topics: Animals; Chromatography, High Pressure Liquid; Circular Dichroism; Glycine; Ligands; Models, Molecular; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Xenopus | 2008 |
4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues.
Topics: Amino Acids, Acidic; Animals; Brain; Cell Line; Chromatography, High Pressure Liquid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; In Vitro Techniques; Male; Oocytes; Oxadiazoles; Patch-Clamp Techniques; Potentiometry; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Xenopus laevis | 2010 |
Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Excitatory Amino Acid Agonists; HEK293 Cells; Humans; Ligands; Rats; Receptors, AMPA; Synaptosomes; Triazoles | 2019 |
The cortical lesion of Huntington's disease: further neurochemical characterization, and reproduction of some of the histological and neurochemical features by N-methyl-D-aspartate lesions of rat cortex.
Topics: Age Factors; Aged; Animals; Aspartic Acid; Brain Chemistry; Cholecystokinin; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Humans; Huntington Disease; Male; Middle Aged; N-Methylaspartate; Neurochemistry; Rats; Rats, Sprague-Dawley; Somatostatin; Substance P | 1992 |
Evidence that [3H]glutamate binding sites are masked by biologically relevant endogenous factor on cell membranes of frog spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Cell Membrane; Cytosol; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Kinetics; Membrane Potentials; N-Methylaspartate; Piperazines; Quisqualic Acid; Rana catesbeiana; Spinal Cord | 1992 |
Administration of excitatory amino acid antagonists via microdialysis attenuates the increase in glucose utilization seen following concussive brain injury.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain; Brain Concussion; Dialysis; Energy Metabolism; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Ions; Kynurenic Acid; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Inbred Strains | 1992 |
Presynaptic glutamate receptors regulate noradrenaline release from isolated nerve terminals.
Topics: Animals; Calcium; Desipramine; Dopamine; Glutamates; Glutamic Acid; In Vitro Techniques; Male; N-Methylaspartate; Nerve Endings; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reserpine; Synapses | 1992 |
Glutamate uptake disguises neurotoxic potency of glutamate agonists in cerebral cortex in dissociated cell culture.
Topics: Animals; Aspartic Acid; Astrocytes; Biological Transport; Cell Survival; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; N-Methylaspartate; Rats; Sodium; Stereoisomerism | 1992 |
Neuroprotective effects of the N-methyl-D-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture.
Topics: Animals; Cells, Cultured; Culture Media; Dizocilpine Maleate; Drug Antagonism; Glutamates; Glutamic Acid; Hippocampus; L-Lactate Dehydrogenase; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1992 |
Effects of ovarian steroids on the gonadotropin response to N-methyl-D-aspartate and on hypothalamic excitatory amino acid levels during sexual maturation in female rats.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Estrogens; Female; Follicle Stimulating Hormone; Glutamates; Glutamic Acid; Glycine; Gonadotropin-Releasing Hormone; Gonadotropins; Hypothalamus; Luteinizing Hormone; N-Methylaspartate; Ovary; Preoptic Area; Progesterone; Rats; Rats, Inbred Strains; Sexual Maturation | 1992 |
The antinociceptive activity of excitatory amino acids in the rat brainstem: an anatomical and pharmacological analysis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Mapping; Brain Stem; Diencephalon; Dizocilpine Maleate; Female; Glutamates; Glutamic Acid; Kainic Acid; Male; Medulla Oblongata; Mesencephalon; Microinjections; N-Methylaspartate; Pain; Periaqueductal Gray; Quisqualic Acid; Rats; Rats, Inbred Strains; Reticular Formation; Stereotaxic Techniques | 1992 |
N-methyl-D-aspartate antagonists block fos-like protein expression induced via multiple signaling pathways in cultured cortical neurons.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Blotting, Northern; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Fetus; Glutamates; Glutamic Acid; Immunohistochemistry; N-Methylaspartate; Neurons; Piperazines; Proto-Oncogene Proteins c-fos; Signal Transduction | 1992 |
Excitatory amino acid regulation of gonadotropin secretion: modulation by steroid hormones.
Topics: Animals; Estradiol; Female; Follicle Stimulating Hormone; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Luteinizing Hormone; N-Methylaspartate; Ovariectomy; Radioimmunoassay; Rats; Time Factors | 1992 |
Selective potentiation of NMDA-induced activity and release of excitatory amino acids by dynorphin: possible roles in paralysis and neurotoxicity.
Topics: Animals; Aspartic Acid; Behavior, Animal; Cell Death; Dizocilpine Maleate; Dynorphins; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neurons; Paralysis; Rats; Rats, Inbred Strains; Spinal Cord | 1992 |
Heteromeric NMDA receptors: molecular and functional distinction of subtypes.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Cell Line; Cloning, Molecular; DNA; Glutamates; Glutamic Acid; Glycine; Macromolecular Substances; Magnesium; Membrane Potentials; Molecular Sequence Data; Multigene Family; N-Methylaspartate; Oligonucleotide Probes; Organ Specificity; Peptides; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA, Messenger; Sequence Homology, Nucleic Acid; Transfection | 1992 |
Persisting modification of dendritic calcium influx by excitatory amino acid stimulation in isolated Ca1 neurons.
Topics: Animals; Calcium; Cytosol; Dendrites; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Kinetics; Magnesium; N-Methylaspartate; Neurons; Pyramidal Tracts; Sphingosine | 1992 |
N-methyl-D-aspartate (NMDA) depolarizes glutamate-insensitive neurones in the superficial dorsal horn.
Topics: Animals; Cricetinae; Drug Resistance; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; Mesocricetus; N-Methylaspartate; Neurons; Spinal Cord | 1992 |
L-serine-O-phosphate blocks NMDA-evoked responses in the ampullae of Lorenzini of skates.
Topics: Amino Acids; Animals; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons, Afferent; Phosphoserine; Quisqualic Acid; Skates, Fish; Synapses; Synaptic Transmission | 1992 |
Glutamate, NMDA and NMDA receptor antagonists: cardiovascular effects of intrathecal administration in the rat.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Blood Pressure; Glutamates; Glutamic Acid; Heart Rate; Hexamethonium; Hexamethonium Compounds; Injections, Spinal; Ketamine; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord; Time Factors | 1992 |
Calcium excitability and oscillations in suprachiasmatic nucleus neurons and glia in vitro.
Topics: Animals; Animals, Newborn; Astrocytes; Axons; Calcium; Cells, Cultured; Cytoplasm; Fura-2; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamates; Glutamic Acid; Immunohistochemistry; Kainic Acid; Kinetics; Microscopy, Electron; Microscopy, Fluorescence; Models, Neurological; N-Methylaspartate; Neuroglia; Neurons; Quisqualic Acid; Rats; Serotonin; Suprachiasmatic Nucleus; Synapses; Time Factors | 1992 |
Competitive antagonism of glutamate receptor channels by substituted benzazepines in cultured cortical neurons.
Topics: Animals; Benzazepines; Binding Sites; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1992 |
NMDA-induced increase in [Ca2+]i and 45Ca2+ uptake in acutely dissociated brain cells derived from adult rats.
Topics: Adenosine Triphosphate; Animals; Brain; Calcium; Calcium Radioisotopes; Glutamates; Glutamic Acid; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spectrometry, Fluorescence; Time Factors | 1992 |
Serotonin-stimulated release of [3H]dopamine via reversal of the dopamine transporter in rat striatum and nucleus accumbens: a comparison with release elicited by potassium, N-methyl-D-aspartic acid, glutamic acid and D-amphetamine.
Topics: Amphetamine; Animals; Brain; Dopamine; Drug Interactions; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Piperazines; Potassium; Rats; Rats, Inbred Strains; Serotonin Antagonists | 1992 |
Characterization of 3-carboxy-5-phosphono-1,2,3,4-tetrahydroisoquinoline (SC-48981), a potent competitive N-methy-D-aspartate (NMDA) receptor antagonist, in vitro and in vivo.
Topics: Animals; Binding, Competitive; Cerebellum; Cyclic GMP; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Isoquinolines; Male; Mice; N-Methylaspartate; Organophosphorus Compounds; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Tetrahydroisoquinolines | 1992 |
Repetitive injections of L-glutamic acid, in contrast to those of N-methyl-D,L-aspartic acid, fail to elicit sustained hypothalamic GnRH release in the prepubertal male rhesus monkey (Macaca mulatta).
Topics: Animals; Biological Assay; Glutamates; Glutamic Acid; Gonadotropin-Releasing Hormone; Hypothalamus; Injections, Intravenous; Kainic Acid; Macaca mulatta; Male; N-Methylaspartate; Sexual Maturation; Time Factors | 1992 |
Excitatory amino acid-evoked calcium influx and calcium-dependent neurotoxicity in rat cortical cultures.
Topics: Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Egtazic Acid; Glutamates; Glutamic Acid; Models, Neurological; N-Methylaspartate; Neurons; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate | 1992 |
Glycine response in isolated dorsal cochlear nucleus of C57BL/6J mouse.
Topics: Animals; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Pons; Receptors, Glycine; Receptors, Neurotransmitter; Strychnine | 1992 |
Estradiol selectively regulates agonist binding sites on the N-methyl-D-aspartate receptor complex in the CA1 region of the hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding Sites; Binding, Competitive; Estradiol; Female; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Ovariectomy; Progesterone; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Selective effects of cyanide (100 microM) on the excitatory amino acid-induced elevation of intracellular calcium levels in neuronal culture.
Topics: Amino Acids; Animals; Calcium; Cells, Cultured; Cerebellum; Diltiazem; Glutamates; Glutamic Acid; Kainic Acid; Lanthanum; Membrane Potentials; N-Methylaspartate; Neurons; Potassium Chloride; Quisqualic Acid; Rats; Rats, Inbred Strains; Sodium Cyanide | 1992 |
Pretreatment with NMDA antagonists limits release of excitatory amino acids following traumatic brain injury.
Topics: Amino Acids; Animals; Brain Injuries; Chromatography, High Pressure Liquid; Dextrorphan; Dialysis; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Pipecolic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Differential modulation by dopamine of responses evoked by excitatory amino acids in human cortex.
Topics: Adolescent; Amino Acids; Cerebral Cortex; Child; Child, Preschool; Dopamine; Drug Interactions; Electrophysiology; Glutamates; Glutamic Acid; Humans; N-Methylaspartate; Quisqualic Acid | 1992 |
Insulin-specific sensitization of cultured cerebrocortical neurons to glutamate excitotoxicity.
Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Fibroblast Growth Factor 2; Glutamates; Glutamic Acid; Insulin; Insulin-Like Growth Factor I; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Rats | 1992 |
The effect of hypoxia on neurotransmitter phenotype of forebrain cholinergic neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Cell Hypoxia; Cells, Cultured; Choline O-Acetyltransferase; Embryo, Mammalian; Glutamates; Glutamic Acid; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Growth Factors; Neurons; Phenotype; Prosencephalon; Quinoxalines; Rats; Rats, Inbred Strains | 1992 |
Activation of kappa-opioid receptors depresses electrically evoked excitatory postsynaptic potentials on 5-HT-sensitive neurones in the rat dorsal raphé nucleus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Benzofurans; Bicuculline; Bombesin; Cholecystokinin; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Evoked Potentials; Glutamates; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Naloxone; Naltrexone; Neurons; Picrotoxin; Prazosin; Pyrrolidines; Quinoxalines; Raphe Nuclei; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin; Synapses; Tetrodotoxin | 1992 |
Interaction between thyrotropin-releasing hormone (TRH) and NMDA-receptor-mediated responses in hypoglossal motoneurones.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Brain Stem; Evoked Potentials; Glutamates; Glutamic Acid; Guinea Pigs; Hypoglossal Nerve; In Vitro Techniques; Membrane Potentials; Motor Neurons; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Synapses; Tetrodotoxin; Thyrotropin-Releasing Hormone | 1992 |
Regulation of excitatory amino acid release by N-methyl-D-aspartate receptors in rat striatum: in vivo microdialysis studies.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Extracellular Space; Fluorometry; Glutamates; Glutamic Acid; Kynurenic Acid; Male; N-Methylaspartate; Perfusion; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serine | 1992 |
N-methyl-D-aspartate exposure blocks glutamate toxicity in cultured cerebellar granule cells.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Culture Media; Cytoplasmic Granules; Excitatory Amino Acid Antagonists; Glucose; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Ouabain; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sensitivity and Specificity; Tritium | 1992 |
Epidermal growth factor selectively enhances NMDA receptor-mediated increase of intracellular Ca2+ concentration in rat hippocampal neurons.
Topics: Animals; Calcium; Epidermal Growth Factor; Fura-2; Glutamates; Glutamic Acid; Hippocampus; N-Methylaspartate; Neuronal Plasticity; Neurons; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins | 1992 |
Glutamate-induced energetic stress in hippocampal slices: evidence against NMDA and glutamate uptake as mediators.
Topics: Animals; Energy Metabolism; Gerbillinae; Glutamates; Glutamic Acid; Glycolysis; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Potassium; Receptors, N-Methyl-D-Aspartate | 1992 |
Inhibitory effect of CCK-8 and ceruletide on glutamate-induced rises in intracellular free calcium concentrations in rat neuron cultures.
Topics: Animals; Calcium; Cells, Cultured; Ceruletide; Cholecystokinin; Cytarabine; Female; Fura-2; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Pregnancy; Rats; Rats, Wistar; Receptors, Cholecystokinin | 1992 |
Cortical AMPA receptors: age-dependent regulation by cellular depolarization and agonist stimulation.
Topics: Aging; Animals; Cerebral Cortex; Glutamates; Glutamic Acid; Kainic Acid; Male; Membrane Potentials; Muscimol; N-Methylaspartate; Neuronal Plasticity; Quisqualic Acid; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, AMPA; Receptors, Neurotransmitter; Veratridine | 1992 |
The neuroprotective properties of ifenprodil, a novel NMDA receptor antagonist, in neuronal cell culture toxicity studies.
Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cyanates; Dizocilpine Maleate; Glutamates; Glutamic Acid; Kainic Acid; Mice; N-Methylaspartate; Neurons; Piperidines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate | 1992 |
Cyanide selectively augments kainate- but not NMDA-induced release of glutamate and taurine.
Topics: Animals; Cells, Cultured; Cerebellum; Cyanides; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Taurine | 1992 |
N-acetylaspartylglutamate acts as an agonist upon homomeric NMDA receptor (NMDAR1) expressed in Xenopus oocytes.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cloning, Molecular; Dipeptides; Dose-Response Relationship, Drug; Female; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Membrane Potentials; N-Methylaspartate; Oocytes; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transcription, Genetic; Xenopus laevis | 1992 |
3-[(+-)-2-carboxypiperazin-4-yl]propyl-1-phosphonic acid recognizes two N-methyl-D-aspartate binding sites in rat cerebral cortex membranes.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1992 |
Structural determinants of barium permeation and rectification in non-NMDA glutamate receptor channels.
Topics: Amino Acid Sequence; Animals; Arginine; Barium; Glutamates; Glutamic Acid; Glutamine; Molecular Sequence Data; Mutation; N-Methylaspartate; Permeability; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Xenopus | 1992 |
Photoperiodic regulation of glutamatergic stimulation of secretion of luteinizing hormone in male Syrian hamsters.
Topics: Animals; Cricetinae; Dizocilpine Maleate; Glutamates; Glutamic Acid; Light; Luteinizing Hormone; Male; Mesocricetus; N-Methylaspartate; Orchiectomy; Periodicity; Secretory Rate; Stimulation, Chemical; Testosterone | 1992 |
Relationship between dopamine release in the rat nucleus accumbens and the discharge activity of dopaminergic neurons during local in vivo application of amino acids in the ventral tegmental area.
Topics: Animals; Brain; Dopamine; Electrophysiology; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neurons; Nucleus Accumbens; Pargyline; Quisqualic Acid; Rats; Rats, Wistar; Stereotaxic Techniques | 1992 |
Excitatory effect of N-methyl-D-aspartate and kainate receptor on the 2-deoxyglucose uptake in the rat suprachiasmatic nucleus in vitro.
Topics: Animals; Deoxyglucose; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Motor Activity; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Suprachiasmatic Nucleus | 1992 |
Synaptic and nonsynaptic determinants of excitability changes in aluminum-intoxicated rabbit CA1 pyramidal neurons studied in vitro.
Topics: Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Chlorides; Culture Techniques; Dose-Response Relationship, Drug; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; N-Methylaspartate; Nerve Degeneration; Neurofibrils; Neurons; Rabbits; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1992 |
MK-801 protects retinal neurons from hypoxia and the toxicity of glutamate and aspartate.
Topics: Animals; Culture Techniques; Dextromethorphan; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hypoxia; Kynurenic Acid; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Retina | 1992 |
The regional vulnerability to hypoglycemia-induced neurotoxicity in organotypic hippocampal culture: protection by early tetrodotoxin or delayed MK-801.
Topics: Animals; Aspartic Acid; Culture Techniques; Deoxyglucose; Dizocilpine Maleate; Glucose; Glutamates; Glutamic Acid; Hippocampus; Histological Techniques; Hypoglycemia; N-Methylaspartate; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Time Factors | 1992 |
Inhibitory effects of the antiparkinsonian drugs memantine and amantadine on N-methyl-D-aspartate-evoked acetylcholine release in the rabbit caudate nucleus in vitro.
Topics: Acetylcholine; Amantadine; Animals; Caudate Nucleus; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Magnesium; Male; Memantine; N-Methylaspartate; Rabbits; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Tritium | 1992 |
Activation and desensitization of N-methyl-D-aspartate receptors in nucleated outside-out patches from mouse neurones.
Topics: Animals; Cells, Cultured; Electrophysiology; Glutamates; Glutamic Acid; Kinetics; Mice; Models, Chemical; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate | 1992 |
Apamin reduces the late afterhyperpolarization of lamprey spinal neurons, with little effect on fictive swimming.
Topics: Animals; Apamin; Glutamates; Glutamic Acid; Lampreys; Membrane Potentials; Motor Neurons; N-Methylaspartate; Swimming | 1992 |
A novel inhibitor of glutamate release reduces excitotoxic injury in vitro.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; N-Methylaspartate; Neurons; Neurotoxins; Potassium Chloride; Pyrimidines; Rats; Rats, Sprague-Dawley; Sodium Channels; Tetrodotoxin; Veratridine | 1992 |
Intrathecal administration of non-NMDA receptor agonists increases arterial pressure and heart rate in the rat.
Topics: Animals; Blood Pressure; Carbachol; Ganglia, Autonomic; Ganglionic Blockers; Glutamates; Glutamic Acid; Heart Rate; Hexamethonium; Hexamethonium Compounds; Injections, Spinal; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptic Transmission | 1992 |
Effect of magnesium on calcium influx activated by glutamate and its agonists in cultured cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Calcium Radioisotopes; Cells, Cultured; Cerebellum; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Nifedipine; Phencyclidine; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Verapamil | 1992 |
A highly potent and selective N-methyl-D-aspartate receptor antagonist from the venom of the Agelenopsis aperta spider.
Topics: Agatoxins; Animals; Aspartic Acid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neurotoxins; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spiders | 1992 |
Niacinamide blocks 3-acetylpyridine toxicity of cerebellar granule cells in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebellum; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Mazindol; N-Methylaspartate; Neurons; Niacinamide; Pyridines; Rats; Rats, Sprague-Dawley; Selegiline; Tetrahydrofolates | 1992 |
NMDA receptors assessed by autoradiography with [3H]L-689,560 are present but not enriched on corticofugal-projecting pyramidal neurones.
Topics: Aminoquinolines; Animals; Autoradiography; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Male; N-Methylaspartate; Neural Pathways; Neurons, Efferent; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Strychnine; Tritium | 1992 |
Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat.
Topics: Action Potentials; Animals; Animals, Newborn; Aspartic Acid; Brain Stem; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Kainic Acid; Locomotion; N-Methylaspartate; Nerve Net; Quisqualic Acid; Rats; Rats, Wistar; Serotonin; Spinal Cord | 1992 |
N-methyl-D-aspartate (NMDA) and non-NMDA (metabotropic) type glutamate receptors modulate the membrane potential of the Schwann cell of the squid giant nerve fibre.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminobutyrates; Animals; Axons; Decapodiformes; Dipeptides; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Membrane Potentials; N-Methylaspartate; Quinoxalines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Schwann Cells | 1992 |
The efferent modulation of mammalian inner hair cell afferents.
Topics: Acetylcholine; Animals; Dendrites; Electric Stimulation; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory, Inner; Male; Microelectrodes; N-Methylaspartate; Neurons, Afferent; Neurons, Efferent; Synaptic Transmission | 1992 |
Glutamate receptor agonists stimulate nitric oxide synthase in primary cultures of cerebellar granule cells.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Calcium; Cells, Cultured; Cerebellum; Citrulline; Cyclic GMP; Glutamates; Glutamic Acid; Granulocytes; Kainic Acid; N-Methylaspartate; Nitric Oxide Synthase; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1992 |
N-methyl-D-aspartic acid (NMDA) and non-NMDA receptors regulating hippocampal norepinephrine release. I. Location on axon terminals and pharmacological characterization.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Axons; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptosomes | 1992 |
Potentiation of NMDA receptor currents by arachidonic acid.
Topics: Animals; Arachidonic Acid; Aspartic Acid; Calcium; Cerebellum; Drug Synergism; Electric Conductivity; Glutamates; Glutamic Acid; Ion Channel Gating; Ion Channels; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems | 1992 |
Possible role of cGMP in excitatory amino acid induced cytotoxicity in cultured cerebral cortical neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cholera Toxin; Cyclic GMP; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Mice; N-Methylaspartate; Neurons; Pertussis Toxin; Quisqualic Acid; Time Factors; Virulence Factors, Bordetella | 1992 |
Presynaptic modulation of amino acid release from synaptosomes.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Brain; Calcium; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Ibotenic Acid; Kinetics; Male; N-Methylaspartate; Potassium Chloride; Quinoxalines; Rats; Rats, Inbred Strains; Synapses; Synaptosomes | 1992 |
Excitatory amino acid receptors on isolated retinal ganglion cells from the goldfish.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cells, Cultured; Chlorides; Electrophysiology; Glutamates; Glutamic Acid; Goldfish; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Retinal Ganglion Cells; Sodium | 1992 |
Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainate in cultured cerebral cortical neu
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Dantrolene; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Mice; N-Methylaspartate; Neurotoxins; Quisqualic Acid; Verapamil | 1992 |
Kindling enhances sensitivity of CA3 hippocampal pyramidal cells to NMDA.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kindling, Neurologic; Magnesium; Male; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains | 1992 |
Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy.
Topics: Acute Disease; Animals; Brain; Brain Ischemia; Diffusion; Female; Glutamates; Glutamic Acid; Magnetic Resonance Imaging; N-Methylaspartate; Ouabain; Rats; Rats, Inbred Strains; Staining and Labeling | 1992 |
Purification of AMPA type glutamate receptor by a spider toxin.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cattle; Cerebellum; Chloride Channels; Chromatography, Affinity; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Glutamates; Glutamic Acid; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Kinetics; Liposomes; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Quisqualic Acid; Receptors, AMPA; Receptors, Neurotransmitter; Spider Venoms | 1992 |
NMDA treatment and K(+)-induced depolarization selectively promote the expression of an NMDA-preferring class of the ionotropic glutamate receptors in cerebellar granule neurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cell Survival; Cells, Cultured; Cerebellar Cortex; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Potassium; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Up-Regulation | 1992 |
L-glutamate-evoked release of dopamine from synaptosomes of the rat striatum: involvement of AMPA and N-methyl-D-aspartate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stimulation, Chemical; Synaptosomes | 1992 |
Neuronal loss or replacement in the injured adult cerebral neocortex induces extensive remodeling of intrinsic and afferent neural systems.
Topics: Afferent Pathways; Analysis of Variance; Animals; Axonal Transport; Cerebral Cortex; Choline O-Acetyltransferase; Female; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Nerve Regeneration; Neurons; Neurotoxins; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Sympathectomy | 1992 |
Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cycloleucine; Drug Synergism; Glutamates; Glutamic Acid; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Myocardial Contraction; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Synapses; Synaptic Transmission | 1992 |
Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hyperalgesia; Ibotenic Acid; Injections, Spinal; N-Methylaspartate; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1992 |
Glutamatergic regulation of histamine release from rat hypothalamus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Glutamates; Glutamic Acid; Histamine Release; Hypothalamus, Anterior; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1992 |
Uncompetitive antagonist binding: a biochemical index of activation of the NMDA receptor-coupled ion channel.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Culture Techniques; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1992 |
Acetylcholine release from the rabbit retina mediated by kainate receptors.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Choline; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Rabbits; Receptors, Kainic Acid; Receptors, Neurotransmitter; Retina | 1991 |
Neurochemical characterization of excitotoxin lesions in the cerebral cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Homocysteine; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; NADPH Dehydrogenase; Neuropeptides; Neurotoxins; Neurotransmitter Agents; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1991 |
Excitotoxic brain injury suppresses striatal high-affinity glutamate uptake in perinatal rats.
Topics: Animals; Animals, Newborn; Binding, Competitive; Brain; Corpus Striatum; Dizocilpine Maleate; Glutamates; Glutamic Acid; N-Methylaspartate; Rats; Time Factors | 1991 |
Dual effect of glycine on isolated rat suprachiasmatic neurons.
Topics: Animals; Electrophysiology; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Inbred Strains; Strychnine; Suprachiasmatic Nucleus | 1991 |
Effects of glutamate, quisqualate, and N-methyl-D-aspartate in neonatal brain.
Topics: Amino Acids; Animals; Animals, Newborn; Brain; Brain Ischemia; Female; Glucose; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Organ Specificity; Phosphocreatine; Quisqualic Acid; Rats; Rats, Inbred Strains | 1991 |
Control of postsynaptic Ca2+ influx in developing neocortex by excitatory and inhibitory neurotransmitters.
Topics: Acetylcholine; Animals; Biological Transport, Active; Calcium; Calcium Channels; Carbachol; Cats; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; N-Methylaspartate; Neurons; Neurotransmitter Agents; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate | 1991 |
Cell damage associated with changing the medium of mesencephalic cultures in serum-free medium is mediated via N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Buffers; Cells, Cultured; Culture Media; Dizocilpine Maleate; Glutamates; Glutamic Acid; Mesencephalon; N-Methylaspartate; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 1991 |
Electrogenic uptake contributes a major component of the depolarizing action of L-glutamate in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biological Transport, Active; Electrophysiology; Glutamates; Glutamic Acid; Hippocampus; Homocysteine; In Vitro Techniques; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Synaptic Transmission | 1991 |
Ipsilateral but not contralateral blockade of excitatory amino acid receptors in the caudal ventrolateral medulla inhibits aortic baroreceptor reflex in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aorta; Blood Pressure; Dizocilpine Maleate; Electric Stimulation; Glutamates; Glutamic Acid; Heart Rate; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; Muscimol; N-Methylaspartate; Pressoreceptors; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Reflex; Synaptic Transmission | 1991 |
Regulation of gamma-aminobutyric acidA receptor subunit expression by activation of N-methyl-D-aspartate-selective glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Base Sequence; Dizocilpine Maleate; Dose-Response Relationship, Drug; Down-Regulation; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamates; Glutamic Acid; Molecular Sequence Data; Muscimol; N-Methylaspartate; Polymerase Chain Reaction; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger | 1991 |
Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-methyl-D-aspartate receptor agonist responses in rat cultured cortical neurons.
Topics: Animals; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Osmolar Concentration; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate; Sodium | 1991 |
Interaction of ethanol and L-glutamate in the guinea pig ileum myenteric plexus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Atropine; Electric Stimulation; Ethanol; Female; Glutamates; Glutamic Acid; Guinea Pigs; Histamine; In Vitro Techniques; Magnesium; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serotonin; Tetrodotoxin | 1991 |
Increased excitotoxic vulnerability of cortical cultures with reduced levels of glutathione.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cerebral Cortex; Female; Glutamates; Glutamic Acid; Glutathione; L-Lactate Dehydrogenase; Methionine Sulfoximine; Mice; N-Methylaspartate; Pregnancy | 1991 |
Met-enkephalin release from slices of the rat striatum and globus pallidus: stimulation by excitatory amino acids.
Topics: Amino Acids; Animals; Corpus Striatum; Enkephalin, Methionine; Globus Pallidus; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Potassium; Quisqualic Acid; Radioimmunoassay; Rats; Rats, Inbred Strains; Stimulation, Chemical | 1991 |
Activation of presynaptic 5-hydroxytryptamine1-like receptors on glutamatergic terminals inhibits N-methyl-D-aspartate-induced cyclic GMP production in rat cerebellar slices.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Calcium; Cerebellum; Citalopram; Cyclic GMP; Fenfluramine; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Methiothepin; N-Methylaspartate; Potassium; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1991 |
Accumulation of extracellular glutamate and neuronal death in astrocyte-poor cortical cultures exposed to glutamine.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Astrocytes; Cell Survival; Cells, Cultured; Cerebral Cortex; Extracellular Space; Glutamates; Glutamic Acid; Glutamine; N-Methylaspartate; Neurons; Pipecolic Acids; Quinoxalines; Rats; Rats, Inbred Strains | 1991 |
L-argininosuccinate modulates L-glutamate response in acutely isolated cerebellar neurons of immature rat.
Topics: Animals; Argininosuccinic Acid; Calcium; Cells, Cultured; Cerebellum; Fura-2; Glutamates; Glutamic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence | 1991 |
Intracellular calcium in NCB-20 cells: elevation by depolarization and ethanol but not by glutamate.
Topics: Animals; Calcium; Calcium Radioisotopes; Cell Survival; Cricetinae; Ethanol; Fura-2; Glutamates; Glutamic Acid; Mice; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Tumor Cells, Cultured | 1991 |
Modification of the responses of primate spinothalamic neurons to mechanical stimulation by excitatory amino acids and an N-methyl-D-aspartate antagonist.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Glutamates; Glutamic Acid; Macaca fascicularis; N-Methylaspartate; Neurons; Quisqualic Acid; Spinothalamic Tracts | 1991 |
Autoradiographic characterization of [3H]L-glutamate binding sites in developing mouse cerebellar cortex.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Binding, Competitive; Calcium; Cerebellar Cortex; Chlorides; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Mice; N-Methylaspartate; Protein Binding; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses | 1991 |
GABA and glutamate interact in the substantia innominata/lateral preoptic area to modulate locomotor activity.
Topics: 2-Aminoadipic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Ibotenic Acid; Male; Motor Activity; Muscimol; N-Methylaspartate; Picrotoxin; Preoptic Area; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Glutamate; Receptors, Neurotransmitter | 1991 |
Transmitter-gated currents of GABAergic amacrine-like cells in chick retinal cultures.
Topics: Amino Acids; Animals; Cells, Cultured; Chick Embryo; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Receptors, GABA-A; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina | 1991 |
Quinolinate differentiates between forebrain and cerebellar NMDA receptors.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Cerebellum; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kinetics; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
N-methyl-D-aspartate (NMDA) and non-NMDA type glutamate receptors are present on squid giant axon Schwann cells.
Topics: Animals; Axons; Decapodiformes; Differential Threshold; Glutamates; Glutamic Acid; Membrane Potentials; N-Methylaspartate; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Schwann Cells | 1991 |
Persistent pulsatile release of glutamate induced by N-methyl-D-aspartate in neonatal rat hippocampal neurones.
Topics: Action Potentials; Animals; Animals, Newborn; Caffeine; Calcium; Calcium Channels; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Potassium Channels; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Time Factors | 1991 |
Glutamate and aspartate immunoreactivity in hypothalamic presynaptic axons.
Topics: Animals; Antibody Specificity; Aspartic Acid; Axons; Calcium; Enzyme-Linked Immunosorbent Assay; Fixatives; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hypothalamus; Immune Sera; Immunoblotting; Immunohistochemistry; N-Methylaspartate; Rats; Synapses | 1991 |
Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity.
Topics: 2-Amino-5-phosphonovalerate; Alanine Transaminase; Animals; Calcium; Dizocilpine Maleate; Glutamates; Glutamic Acid; HIV Envelope Protein gp120; N-Methylaspartate; Neurotoxins; Osmolar Concentration; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells | 1991 |
Tyrosine 70 fine-tunes the catalytic efficiency of aspartate aminotransferase.
Topics: Aspartate Aminotransferases; Aspartic Acid; Enzyme Inhibitors; Escherichia coli; Glutamates; Glutamic Acid; Isotopes; Ketoglutaric Acids; Kinetics; Maleates; Mutation; N-Methylaspartate; Spectrophotometry; Tyrosine | 1991 |
NMDA receptors in the intermediolateral column of the spinal cord mediate sympathoexcitatory cardiac responses elicited from the ventrolateral medullary pressor area.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Convulsants; Glutamates; Glutamic Acid; Heart Rate; Ibotenic Acid; Kainic Acid; Male; Medulla Oblongata; Microinjections; Myocardial Contraction; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1991 |
Quantitative autoradiographic study of L-glutamate binding sites in normal and atrophic human cerebellum.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adolescent; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cerebellum; Female; Glutamates; Glutamic Acid; Humans; Ibotenic Acid; Male; N-Methylaspartate; Olivopontocerebellar Atrophies; Piperazines; Quinoxalines; Quisqualic Acid; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
Activation of excitatory amino acid receptors cannot alone account for anoxia-induced impairment of protein synthesis in rat hippocampal slices.
Topics: Animals; Aspartic Acid; Carbon Radioisotopes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; Hypoxia; Kainic Acid; Lysine; Male; N-Methylaspartate; Nerve Tissue Proteins; Phenazocine; Phencyclidine; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate | 1991 |
N-methyl-D-aspartate receptor activation increases cAMP levels and voltage-gated Ca2+ channel activity in area CA1 of hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Calcium Channels; Cyclic AMP; Egtazic Acid; Electric Stimulation; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Selective blockade of non-NMDA receptors does not block rapidly triggered glutamate-induced neuronal death.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cell Line; Cell Survival; Cerebral Cortex; Fetus; Glutamates; Glutamic Acid; Glycine; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a mu opioid.
Topics: Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Activation; Glutamates; Glutamic Acid; Medulla Oblongata; N-Methylaspartate; Neurons; Protein Kinase C; Rats; Receptors, N-Methyl-D-Aspartate | 1991 |
Chronic application of NMDA decreases the NMDA sensitivity of the evoked tectal potential in the frog.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electric Stimulation; Evoked Potentials; Glutamates; Glutamic Acid; N-Methylaspartate; Optic Nerve; Quisqualic Acid; Rana pipiens; Receptors, N-Methyl-D-Aspartate; Superior Colliculi; Synapses | 1991 |
Dipeptides--analogues of N-acetylaspartylglutamate inhibit convulsive effects of excitatory amino acids in mice.
Topics: Animals; Cerebral Ventricles; Dipeptides; Glutamates; Glutamic Acid; Injections, Intraventricular; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurotoxins; Pentylenetetrazole; Seizures; Structure-Activity Relationship | 1991 |
Retinogeniculate transmission by NMDA and non-NMDA receptors in the cat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cats; Geniculate Bodies; Glutamates; Glutamic Acid; Iontophoresis; Kynurenic Acid; N-Methylaspartate; Photic Stimulation; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Retina; Synaptic Transmission | 1991 |
Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture.
Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; N-Methylaspartate; Nifedipine; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells | 1991 |
Evoked field potential changes in the rat hippocampus produced by toxic doses of glutamate agonists and metabolic inhibitors: correlation with subsequent neuronal death.
Topics: Animals; Cell Death; Electric Stimulation; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Iodoacetates; Iodoacetic Acid; Kainic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1991 |
Unilateral up-regulation of glutamate receptors in limbic regions of amygdaloid-kindled rats.
Topics: Amygdala; Animals; Autoradiography; Glutamates; Glutamic Acid; Hippocampus; Kindling, Neurologic; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Up-Regulation | 1991 |
Glutamate neurotoxicity in spinal cord cell culture.
Topics: Animals; Cells, Cultured; Dextromethorphan; Dextrorphan; Glutamates; Glutamic Acid; Glycine; N-Methylaspartate; Neurons; Spinal Cord | 1991 |
Kainate and NMDA toxicity for cultured developing and adult rat spiral ganglion neurons: further evidence for a glutamatergic excitatory neurotransmission at the inner hair cell synapse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Cell Survival; Cells, Cultured; Cochlea; Ganglia; Glutamates; Glutamic Acid; Hair Cells, Auditory, Inner; Immunohistochemistry; In Vitro Techniques; Indicators and Reagents; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Neurons, Afferent; Organ of Corti; Quisqualic Acid; Rats; Rats, Inbred Strains; Synaptic Transmission | 1991 |
Mediation of visual responses in the nucleus of the optic tract in cats and rats by excitatory amino acid receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cats; Evoked Potentials; Evoked Potentials, Visual; Female; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neurons; Optic Chiasm; Photic Stimulation; Quinoxalines; Quisqualic Acid; Rats; Receptors, Neurotransmitter | 1991 |
Receptor sub-types involved in responses of Purkinje cell to exogenous excitatory amino acids and local electrical stimulation in cerebellar slices in the rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Amino Acids; Animals; Aspartic Acid; Bicuculline; Cerebellum; Electric Stimulation; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Purkinje Cells; Quinoxalines; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1991 |
Excitatory amino acids evoke taurine release from cerebral cortex slices from adult and developing mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dipeptides; Female; Glutamates; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Neurotoxins; Potassium; Quisqualic Acid; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Secretory Rate; Stimulation, Chemical; Taurine | 1991 |
A novel selective NMDA agonist, N-phthalamoyl-L-glutamic acid (PhGA).
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Hippocampus; Magnesium; N-Methylaspartate; Neurons; Osmolar Concentration | 1991 |
The pharmacological profile of glutamate-evoked ascorbic acid efflux measured by in vivo electrochemistry.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Animals; Ascorbic Acid; Aspartic Acid; Brain; Corpus Striatum; Electric Stimulation; Electrochemistry; Globus Pallidus; Glutamates; Glutamic Acid; Hippocampus; Kynurenic Acid; Male; Microinjections; N-Methylaspartate; Organ Specificity; Potentiometry; Rats; Rats, Inbred Strains; Stereotaxic Techniques; Thalamus | 1991 |
In vivo study of NMDA-sensitive glutamate receptor by fluorothienylcyclohexylpiperidine [correction of fluorothienylcycloexylpiperidine], a possible ligand for positron emission tomography.
Topics: Animals; Binding Sites; Brain; Cerebral Cortex; Corpus Striatum; Glutamates; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Injections, Intravenous; Macaca mulatta; Male; Mice; N-Methylaspartate; Piperidines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Membranes; Tomography, Emission-Computed | 1991 |
Release of arachidonic acid by NMDA-receptor activation in the rat hippocampus.
Topics: Animals; Arachidonic Acid; Electric Stimulation; Fatty Acids; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Melitten; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synapses | 1991 |
Excitotoxicity in the embryonic chick spinal cord.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; beta-Alanine; Chick Embryo; Cyanobacteria Toxins; Dizocilpine Maleate; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Quinoxalines; Quisqualic Acid; Spinal Cord | 1991 |
Evidence that activation of N-methyl-D-aspartate (NMDA) and non-NMDA receptors within the nucleus tractus solitarii triggers swallowing.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Decerebrate State; Deglutition; Facial Nerve; Glutamates; Glutamic Acid; Medulla Oblongata; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
Ammonia-induced alterations in glutamate and muscimol binding to cerebellar synaptic membranes.
Topics: Ammonia; Animals; Cerebellum; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Muscimol; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Glutamate; Receptors, Neurotransmitter; Synaptic Membranes | 1991 |
N-methyl-D-aspartate receptor-mediated spontaneous activity in cerebellar granule cells in culture.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Calcium Channels; Cells, Cultured; Cerebellum; Cobalt; Dizocilpine Maleate; Glutamates; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1991 |
An arthropod NMDA receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Astacoidea; Cesium; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Immunoenzyme Techniques; Interneurons; Kynurenic Acid; Magnesium; Membrane Potentials; N-Methylaspartate; Photic Stimulation; Receptors, N-Methyl-D-Aspartate; Vision, Ocular | 1991 |
Striatal N-methyl-D-aspartate receptors in haloperidol-induced catalepsy.
Topics: Animals; Catalepsy; Cerebral Cortex; Corpus Striatum; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Haloperidol; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Valine | 1991 |
Intercellular action of nitric oxide in adult rat cerebellar slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebellum; Cyclic GMP; Drug Interactions; Glutamates; Glutamic Acid; Hemoglobins; Hydroxylamine; Hydroxylamines; Ibotenic Acid; Kainic Acid; Molsidomine; N-Methylaspartate; Nitric Oxide; Nitroprusside; Penicillamine; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; S-Nitroso-N-Acetylpenicillamine | 1991 |
Neurotoxic activation of glutamate receptors induces an extended neuronal depolarization in cultured hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Cells, Cultured; Dizocilpine Maleate; Electrophysiology; Glutamates; Glutamic Acid; Hippocampus; Membrane Potentials; N-Methylaspartate; Neurons; Neurotoxins; Quinoxalines; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1991 |
Vinpocetine preferentially antagonizes quisqualate/AMPA receptor responses: evidence from release and ligand binding studies.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cerebral Cortex; Corpus Striatum; Dopamine; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Male; Membranes; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, AMPA; Receptors, Cell Surface; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tritium; Vinca Alkaloids | 1991 |
Selective blockade of N-methyl-D-aspartate receptor function by the nitric oxide donor, nitroprusside.
Topics: Action Potentials; Animals; Cerebellum; Glutamates; Glutamic Acid; Molsidomine; N-Methylaspartate; Nitric Oxide; Nitroprusside; Penicillamine; Rats; Receptors, N-Methyl-D-Aspartate; S-Nitroso-N-Acetylpenicillamine; Stimulation, Chemical; Synapses | 1991 |
Sensitivity of rubrospinal neurons to excitatory amino acids in the rat red nucleus in vivo.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Aspartic Acid; Cats; Cerebellum; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Iontophoresis; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Red Nucleus; Species Specificity | 1991 |
Stimulation of noradrenaline release in the cerebral cortex via presynaptic N-methyl-D-aspartate (NMDA) receptors and their pharmacological characterization.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Magnesium; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1991 |
Glutamate, kainate and quisqualate enhance GABA-dependent chloride uptake in cortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biological Transport; Cerebral Cortex; Chloride Channels; Chlorides; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Inbred Strains; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Receptors, GABA-A | 1990 |
Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord.
Topics: Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Drug Interactions; Glutamates; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Pain; Pain Measurement; Quisqualic Acid; Rats; Rats, Inbred Strains; Reaction Time; Self Mutilation; Spinal Cord; Substance P; Taurine | 1990 |
Glutamate-induced increases in intracellular Ca2+ in cultured frog tectal cells mediated by direct activation of NMDA receptor channels.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cells, Cultured; Dizocilpine Maleate; Electrophysiology; Glutamates; Glutamic Acid; Intracellular Membranes; Ion Channels; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Rana pipiens; Receptors, N-Methyl-D-Aspartate; Superior Colliculi | 1991 |
Substance P modulates glutamate-induced currents in acutely isolated rat spinal dorsal horn neurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Evoked Potentials; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Substance P | 1990 |
Glutamate: three meetings but how many receptors? Excitatory Amino Acids 1990: a Fidia Research Foundation Symposium, Padua, Italy, May 21-26, 1990. Excitatory Amino Acid Receptors in the Brain: Functions and Disorders, Montreal, Canada, June 23-24, 1990.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Glutamates; Glutamic Acid; GTP-Binding Proteins; Ibotenic Acid; Ion Channel Gating; Ion Channels; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Quisqualic Acid; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Signal Transduction | 1990 |
Solubilization, partial purification, and reconstitution of glutamate- and N-methyl-D-aspartate-activated cation channels from brain synaptic membranes.
Topics: Animals; Blotting, Western; Brain; Cations; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Glutamates; Glutamic Acid; Ion Channels; Kinetics; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Synaptic Membranes | 1991 |
Isoflurane depresses both glutamate- and peptide-mediated slow synaptic transmission in neonatal rat spinal cord.
Topics: Animals; Animals, Newborn; Glutamates; Glutamic Acid; In Vitro Techniques; Isoflurane; N-Methylaspartate; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Synapses; Synaptic Transmission | 1991 |
Avian locomotion activated by brainstem infusion of neurotransmitter agonists and antagonists. I. Acetylcholine excitatory amino acids and substance P.
Topics: Acetylcholine; Animals; Brain Stem; Carbachol; Choline O-Acetyltransferase; Diffusion; Ducks; Electric Stimulation; Geese; Glutamates; Glutamic Acid; Motor Activity; N-Methylaspartate; Pilocarpine; Reticular Formation; Substance P | 1991 |
Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures.
Topics: Animals; Culture Techniques; Dose-Response Relationship, Drug; Fluorescence; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Osmolar Concentration; Propidium; Staining and Labeling | 1991 |
Absence of implication of L-arginine/nitric oxide pathway on neuronal cell injury induced by L-glutamate or hypoxia.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Brain; Cell Hypoxia; Cells, Cultured; Cyclic GMP; Dizocilpine Maleate; Fetus; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; N-Methylaspartate; Neuroglia; Neurons; Nitric Oxide; Nitroarginine; Nitroprusside; omega-N-Methylarginine; Quisqualic Acid; Rats | 1991 |
Role of excitatory amino acid receptors in K+- and glutamate-evoked release of endogenous adenosine from rat cortical slices.
Topics: Adenosine; Animals; Aspartic Acid; Calcium; Cerebral Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Potassium; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1990 |
[3H]N-[1-(2-thienyl)cyclohexyl]-3,4-piperidine ([3H]TCP) binding in human frontal cortex: decreases in Alzheimer-type dementia.
Topics: Alzheimer Disease; Aspartic Acid; Binding Sites; Frontal Lobe; Glutamates; Glutamic Acid; Humans; Membranes; N-Methylaspartate; Phencyclidine; Reference Values | 1990 |
NMDA receptors mediate poly- and monosynaptic potentials in motoneurons of rat embryos.
Topics: Animals; Aspartic Acid; Electrophysiology; Glutamates; Glutamic Acid; Kainic Acid; Motor Neurons; N-Methylaspartate; Neurons, Afferent; Rats; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Nerve Roots; Synapses; Synaptic Transmission | 1990 |
N-methyl-D-aspartate recognition site ligands modulate activity at the coupled glycine recognition site.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Glutamates; Glutamic Acid; Glycine; Ligands; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines | 1990 |
Effects of hypoxia-ischemia and MK-801 treatment on the binding of a phencyclidine analogue in the developing rat brain.
Topics: Animals; Animals, Newborn; Aspartic Acid; Autoradiography; Binding Sites; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hypoxia; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Tritium | 1990 |
Induction of locomotion in spinal tadpoles by excitatory amino acids and their agonists.
Topics: Animals; Anura; Aspartic Acid; Glutamates; Glutamic Acid; Kainic Acid; Locomotion; Motor Activity; N-Methylaspartate; Spinal Cord; Swimming | 1990 |
Glutamate and glycine induce a negative wave on hippocampal field response through NMDA receptors.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Glycine; Hippocampus; Male; N-Methylaspartate; Neural Inhibition; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Acute- and long-term glutamate-mediated regulation of [Ca++]i in rat hippocampal pyramidal neurons in vitro.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Differential expression of excitatory amino acid receptor subtypes in cultured cerebellar neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Oxadiazoles; Potassium Chloride; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Glutamate uptake in mammalian retinal glia is voltage- and potassium-dependent.
Topics: Animals; Aspartic Acid; Carrier Proteins; Glutamates; Glutamic Acid; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neuroglia; Neurotransmitter Agents; Potassium; Rabbits; Retina | 1990 |
Acetylcholine potentiates responses to N-methyl-D-aspartate in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Action Potentials; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; N-Methylaspartate; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Selective loss of N-methyl-D-aspartate-sensitive L-[3H]glutamate binding sites in rat brain following portacaval anastomosis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ammonia; Animals; Aspartic Acid; Brain; Cerebral Cortex; Corpus Striatum; Down-Regulation; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Kainic Acid; Liver; Male; N-Methylaspartate; Organ Size; Portacaval Shunt, Surgical; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Thalamus | 1990 |
Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Kinetics; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Valine | 1990 |
An electrophysiological study of the action of N-methyl-D-aspartate on excitatory synaptic transmission in the optic tectum of the frog in vitro.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Electrophysiology; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Rana temporaria; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Superior Colliculi; Synapses; Synaptic Transmission | 1990 |
Arachidonic acid released from striatal neurons by joint stimulation of ionotropic and metabotropic quisqualate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Arachidonic Acid; Arachidonic Acids; Aspartic Acid; Cells, Cultured; Corpus Striatum; Cycloleucine; Electrophysiology; Glutamates; Glutamic Acid; Ibotenic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1990 |
In vivo evidence for an inhibitory glutamatergic control of serotonin release in the cat caudate nucleus: involvement of GABA neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Bicuculline; Cats; Caudate Nucleus; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neurons; Riluzole; Serotonin; Spinal Cord; Synaptic Transmission; Tetrodotoxin; Thiazoles | 1990 |
Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-methyl-D-aspartate receptor complex.
Topics: Allosteric Site; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Hippocampus; Ileum; Isometric Contraction; Kinetics; Male; Muscle, Smooth; N-Methylaspartate; Neurons; Norepinephrine; Pyrrolidinones; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Synaptosomes | 1990 |
Mechanisms generating the time course of dual component excitatory synaptic currents recorded in hippocampal slices.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Electrophysiology; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Ketamine; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Temperature; Time Factors | 1990 |
Effect of aspartame on N-methyl-D-aspartate-sensitive L-[3H]glutamate binding sites in rat brain synaptic membranes.
Topics: Animals; Aspartame; Aspartic Acid; Brain; Dipeptides; Glutamates; Glutamic Acid; Kinetics; Male; N-Methylaspartate; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1990 |
The correlation between excitatory amino acid-induced current responses and excitotoxicity in striatal cultures.
Topics: Animals; Cells, Cultured; Corpus Striatum; Glutamates; Glutamic Acid; Glycine; Membrane Potentials; N-Methylaspartate; Neurotransmitter Agents; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Potentiation of glutamate-activated currents in isolated hippocampal neurons.
Topics: Animals; Cell Separation; Electric Conductivity; Glutamates; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons | 1990 |
Generation of inositol phosphates, cytosolic Ca2+, and secretion of noradrenaline in PC12 cells treated with glutamate.
Topics: Adrenal Gland Neoplasms; Animals; Calcium; Cytosol; Glutamates; Glutamic Acid; Inositol Phosphates; N-Methylaspartate; Norepinephrine; Pheochromocytoma; Rats; Tritium; Tumor Cells, Cultured | 1990 |
The glycine antagonist 7-chlorokynurenic acid blocks the effects of N-methyl-D-aspartate on agonist-stimulated phosphoinositide hydrolysis in guinea-pig brain slices.
Topics: Animals; Brain; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Hydrolysis; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Phosphatidylinositols; Receptors, N-Methyl-D-Aspartate | 1990 |
(R)-4-oxo-5-phosphononorvaline: a new competitive glutamate antagonist at the NMDA receptor complex.
Topics: Animals; Binding, Competitive; Cerebellum; Cyclic GMP; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kindling, Neurologic; Mice; Mice, Inbred DBA; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Valine | 1990 |
Excitatory amino acid receptors of guinea pig medial nucleus tractus solitarius neurons.
Topics: Amino Acids; Animals; Glutamates; Glutamic Acid; Guinea Pigs; Kainic Acid; Medulla Oblongata; N-Methylaspartate; Neurons; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface | 1990 |
Glutamate, the dominant excitatory transmitter in neuroendocrine regulation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Axons; Calcium; Electric Stimulation; Glutamates; Glutamic Acid; Hypothalamus; Immunohistochemistry; Kainic Acid; Microscopy, Electron; N-Methylaspartate; Neurons; Neurotransmitter Agents; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Second Messenger Systems; Synapses | 1990 |
Excitatory amino acid receptor agonists stimulate membrane inositol phospholipid hydrolysis and increase cytoplasmic free Ca2+ in primary cultures of retinal neurons.
Topics: Amino Acids; Animals; Calcium; Cells, Cultured; Cyclic GMP; Cytoplasm; Glutamates; Glutamic Acid; Hydrolysis; Kainic Acid; N-Methylaspartate; Neurons; Phosphatidylinositols; Receptors, Amino Acid; Receptors, Cell Surface; Retina | 1990 |
Rapid, sensitive, and simple method for quantification of both neurotoxic and neurotrophic effects of NMDA on cultured cerebellar granule cells.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebellum; Culture Media; Dizocilpine Maleate; Glutamates; Glutamic Acid; Mice; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Potassium | 1990 |
Lack of excitotoxic cell death in serum-free cultures of rat cerebral cortex.
Topics: Amino Acids; Animals; Blood Physiological Phenomena; Cell Survival; Cells, Cultured; Cerebral Cortex; Culture Media; Glutamates; Glutamic Acid; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Inbred Strains | 1990 |
Quisqualate-induced changes in extracellular sodium and calcium concentrations persist in the combined presence of NMDA and non-NMDA receptor antagonists in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Evoked Potentials; Extracellular Space; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Ketamine; Membrane Potentials; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Sodium | 1990 |
Excitotoxins can produce protein degradation in the spinal cord.
Topics: Animals; Calcium; Female; Glutamates; Glutamic Acid; Intermediate Filament Proteins; Kainic Acid; N-Methylaspartate; Neurofilament Proteins; Neurotoxins; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1990 |
Glutamate- and aspartate-induced extracellular potassium and calcium shifts and their relation to those of kainate, quisqualate and N-methyl-D-aspartate in the isolated turtle cerebellum.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cerebellum; Dose-Response Relationship, Drug; Extracellular Space; Glutamates; Glutamic Acid; In Vitro Techniques; Iontophoresis; Kainic Acid; Manganese; N-Methylaspartate; Potassium; Quisqualic Acid; Turtles | 1990 |
Peripubertal treatment with N-methyl-D-aspartic acid or neonatally with monosodium glutamate accelerates sexual maturation in female rats, an effect reversed by MK-801.
Topics: Animals; Animals, Newborn; Dizocilpine Maleate; Female; Glutamates; Glutamic Acid; N-Methylaspartate; Ovulation; Rats; Rats, Inbred Strains; Sexual Maturation; Sodium Glutamate; Vagina | 1990 |
Initiation of swimming activity in the medicinal leech by glutamate, quisqualate and kainate.
Topics: Animals; Glutamates; Glutamic Acid; Kainic Acid; Leeches; Motor Activity; N-Methylaspartate; Quisqualic Acid; Swimming | 1990 |
Competitive inhibition of NMDA-mediated responses by guanine nucleotides in brain synaptic membranes treated with Triton X-100.
Topics: Animals; Binding, Competitive; Brain; Cholera Toxin; Dizocilpine Maleate; Glutamates; Glutamic Acid; Guanine Nucleotides; In Vitro Techniques; Kinetics; N-Methylaspartate; Octoxynol; Polyethylene Glycols; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Surface-Active Agents; Synaptic Membranes | 1990 |
Characterization of Ca2(+)-mobilizing excitatory amino acid receptors in cultured chick cortical cells.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Chick Embryo; Glutamates; Glutamic Acid; Immunohistochemistry; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate | 1990 |
Actions of excitatory amino acids on brisk ganglion cells in the cat retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Anesthesia; Animals; Aspartic Acid; Cats; Electrodes; Glutamates; Glutamic Acid; Ibotenic Acid; Iontophoresis; Kainic Acid; N-Methylaspartate; Photic Stimulation; Quisqualic Acid; Retinal Ganglion Cells | 1990 |
Selective reduction of quisqualate (AMPA) receptors in Alzheimer cerebellum.
Topics: Aged; Aged, 80 and over; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Autoradiography; Cerebellum; Female; Glutamates; Glutamic Acid; Humans; Ibotenic Acid; Kainic Acid; Kinetics; Male; N-Methylaspartate; Radioligand Assay; Receptors, AMPA; Receptors, Neurotransmitter | 1990 |
Swallowing responses induced by microinjection of glutamate and glutamate agonists into the nucleus tractus solitarius of ketamine-anesthetized rats.
Topics: Animals; Deglutition; Glutamates; Glutamic Acid; Ketamine; Medulla Oblongata; Microinjections; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Inbred Strains | 1990 |
A topological model of the NMDA-glycine receptor model.
Topics: 2-Amino-5-phosphonovalerate; Glutamates; Glutamic Acid; Glycine; Models, Molecular; N-Methylaspartate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Quisqualate- and NMDA-sensitive [3H]glutamate binding in primate brain.
Topics: Animals; Autoradiography; Brain Chemistry; Cerebral Cortex; Glutamates; Glutamic Acid; Macaca fascicularis; N-Methylaspartate; Quisqualic Acid | 1990 |
Cytotoxic effect of glutamate and its agonists on mouse hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Cells, Cultured; Dipeptides; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Pregnancy; Quinolinic Acid; Quinolinic Acids | 1990 |
Protection by pyroglutamic acid and some of its newly synthesized derivatives against glutamate-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Glutamates; Glutamic Acid; Indicators and Reagents; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Motor Activity; N-Methylaspartate; Pyrrolidonecarboxylic Acid; Seizures | 1990 |
Rhythmic bursting patterns induced in neurons of the rat nucleus tractus solitarii, in vitro, in response to N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Glutamates; Glutamic Acid; Male; Medulla Oblongata; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Inbred Strains | 1990 |
Glutamate toxicity in immature cortical neurons precedes development of glutamate receptor currents.
Topics: Animals; Cerebral Cortex; Electrophysiology; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; N-Methylaspartate; Neurons; Pregnancy; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Evidence that excitatory amino acids not only activate the receptor channel complex but also lead to use-dependent block.
Topics: Amino Acids; Animals; Aspartic Acid; Chick Embryo; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Neurotransmitter; Spinal Cord | 1986 |
Phencyclidine selectively blocks a spinal action of N-methyl-D-aspartate in mice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glutamates; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Norepinephrine; Oxadiazoles; Phencyclidine; Quisqualic Acid; Spinal Cord; Substance P; Tetrazoles; Valine | 1986 |
Evidence for a magnesium-insensitive membrane resistance increase during NMDA-induced depolarizations in rat neocortical neurons in vitro.
Topics: Animals; Aspartic Acid; Cell Membrane; Electric Conductivity; Frontal Lobe; Glutamates; Glutamic Acid; Ion Channels; Magnesium; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains | 1987 |
A study of amino acid-activated currents recorded from frog motoneurones in vitro.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anterior Horn Cells; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Ion Channels; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neural Conduction; Oxadiazoles; Quisqualic Acid; Rana temporaria; Valine | 1987 |
Use-dependent block of excitatory amino acid currents in cultured neurons by ketamine.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Electric Conductivity; Glutamates; Glutamic Acid; Hippocampus; Ion Channels; Kainic Acid; Ketamine; Membrane Potentials; Mice; N-Methylaspartate; Spinal Cord | 1987 |
Sustained dendritic gradients of Ca2+ induced by excitatory amino acids in CA1 hippocampal neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Benzofurans; Calcium; Dendrites; Fluorescent Dyes; Fura-2; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Ion Channels; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons; Potassium; Protein Kinase C; Sphingosine; Tetrodotoxin | 1988 |
On the kinetics of large-conductance glutamate-receptor ion channels in rat cerebellar granule neurons.
Topics: Animals; Aspartic Acid; Cerebellum; Glutamates; Glutamic Acid; Ion Channels; Membrane Potentials; N-Methylaspartate; Neural Conduction; Neurons; Organ Culture Techniques; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1988 |
Behavior induced by putative nociceptive neurotransmitters is inhibited by adenosine or adenosine analogs coadministered intrathecally.
Topics: Adenosine; Animals; Aspartic Acid; Behavior, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Spinal; Male; Mice; N-Methylaspartate; Neurotransmitter Agents; Pain; Substance P | 1988 |
Noise and single channels activated by excitatory amino acids in rat cerebellar granule neurones.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1988 |
Multiple conductance channels in type-2 cerebellar astrocytes activated by excitatory amino acids.
Topics: Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Cerebellum; Convulsants; Electric Conductivity; Evoked Potentials; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Synaptic Transmission | 1989 |
Excitatory and inhibitory amino acids and peptide-induced responses in acutely isolated rat spinal dorsal horn neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Drug Synergism; Electric Conductivity; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neuropeptides; Oxadiazoles; Peptides; Quisqualic Acid; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1989 |
Release of endogenous excitatory amino acids from turtle photoreceptors.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Electric Stimulation; Glutamates; Glutamic Acid; Hippocampus; Ion Channels; Lanthanum; Membrane Potentials; N-Methylaspartate; Neurons; Photoreceptor Cells; Receptors, Nicotinic; Turtles | 1989 |
Cloning by functional expression of a member of the glutamate receptor family.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; Brain Chemistry; Cloning, Molecular; DNA; Electrophysiology; Gene Expression; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Molecular Sequence Data; Molecular Weight; N-Methylaspartate; Oocytes; Plasmids; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; RNA; Tissue Distribution; Transcription, Genetic; Transfection; Xenopus | 1989 |
L-[3H]glutamate binding to a membrane preparation from crayfish muscle.
Topics: Animals; Aspartic Acid; Astacoidea; Binding, Competitive; Calcium; Cell Membrane; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Muscles; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Stereoisomerism | 1989 |
Modulation of dendritic release of dopamine by N-methyl-D-aspartate receptors in rat substantia nigra.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Dendrites; Dopamine; Glutamates; Glutamic Acid; Glycine; Kainic Acid; Kinetics; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Substantia Nigra; Tetrodotoxin | 1989 |
Characterization of L-glutamate action on the release of endogenous dopamine from the rat caudate-putamen.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Caudate Nucleus; Dopamine; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Oxadiazoles; Phenazocine; Potassium; Putamen; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Pharmacological characterization of voltage-clamped catfish rod horizontal cell responses to kainic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Catfishes; Convulsants; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kinetics; N-Methylaspartate; Oxadiazoles; Photoreceptor Cells; Quisqualic Acid | 1989 |
Effects of a spider toxin (JSTX) on hippocampal CA1 neurons in vitro.
Topics: Action Potentials; Amino Acids; Animals; Arthropod Venoms; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; N-Methylaspartate; Receptors, Amino Acid; Receptors, Cell Surface; Spider Venoms; Time Factors | 1989 |
Excitatory amino acid-evoked release of [3H]GABA from hippocampal neurons in primary culture.
Topics: Animals; Aspartic Acid; Cells, Cultured; Ethers; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Ionomycin; Kainic Acid; N-Methylaspartate; Rats; Rats, Inbred Strains; Veratridine; Zinc | 1989 |
Changes in excitatory amino acid receptor binding in the intact and decorticated rat neostriatum following insulin-induced hypoglycemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain; Caudate Nucleus; Cerebral Cortex; Corpus Striatum; Frontal Lobe; Glutamates; Glutamic Acid; Hypoglycemia; Ibotenic Acid; Insulin; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Solubilization of quisqualate-sensitive [3H]glutamate binding activity from rat retina.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cell Membrane; Glutamates; Glutamic Acid; Kinetics; Male; N-Methylaspartate; Octoxynol; Oxadiazoles; Polyethylene Glycols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Retina; Solubility | 1989 |
Effect of impact trauma on neurotransmitter and nonneurotransmitter amino acids in rat spinal cord.
Topics: Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Kinetics; Laminectomy; Male; N-Methylaspartate; Neurotransmitter Agents; Rats; Serine; Spinal Cord; Spinal Cord Injuries; Taurine; Threonine | 1989 |
Regulation of Ca++ influx into striatal neurons by kainic acid.
Topics: Animals; Aspartic Acid; Calcium; Calcium Channels; Corpus Striatum; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Potassium; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium | 1989 |
K+ differentially affects the excitatory amino acids- and carbachol-elicited inositol phosphate formation in rat brain synaptoneurosomes.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Carbachol; Frontal Lobe; Glutamates; Glutamic Acid; Inositol Phosphates; N-Methylaspartate; Oxadiazoles; Potassium; Quisqualic Acid; Rats; Sugar Phosphates; Synaptosomes | 1989 |
Auditory nerve neurotransmitter acts on a kainate receptor: evidence from intracellular recordings in brain slices from mice.
Topics: Action Potentials; Animals; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Mice; Mice, Inbred CBA; N-Methylaspartate; Receptors, Glutamate; Receptors, Neurotransmitter; Vestibulocochlear Nerve | 1989 |
NMDA receptor regulation of neuronal morphology in cultured hippocampal neurons.
Topics: Animals; Animals, Newborn; Anticonvulsants; Aspartic Acid; Cells, Cultured; Culture Media; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
The role of excitatory amino acids and NMDA receptors in traumatic brain injury.
Topics: Animals; Aspartic Acid; Binding, Competitive; Brain; Brain Injuries; Dextrorphan; Glutamates; Glutamic Acid; Magnesium; Magnetic Resonance Spectroscopy; Male; N-Methylaspartate; Phosphates; Phosphocreatine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
N-methyl-D-aspartate-sensitive [3H]glutamate binding sites in brain synaptic membranes treated with Triton X-100.
Topics: Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Brain; Glutamates; Glutamic Acid; Kinetics; Kynurenic Acid; N-Methylaspartate; Octoxynol; Polyethylene Glycols; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship; Synaptic Membranes; Temperature; Tissue Distribution | 1989 |
Excitatory amino acids enhance dissociation of zinc from soluble protein in cytosol of rat hippocampus.
Topics: Amino Acids; Animals; Aspartic Acid; Cytosol; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Nerve Tissue Proteins; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Zinc | 1989 |
Biochemical characterization of an autoradiographic method for studying excitatory amino acid receptors using L-[3H]glutamate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Binding, Competitive; Brain; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Kinetics; Male; N-Methylaspartate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Software; Tritium | 1989 |
Characterization of deep dorsal horn neurones in the rat spinal cord in vitro: synaptic and excitatory amino acid induced excitations.
Topics: Animals; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Spinal Cord; Synapses | 1989 |
Extracellular concentrations of aspartate and glutamate in rat neostriatum following chemical stimulation of frontal cortex.
Topics: Animals; Aspartic Acid; Bicuculline; Corpus Striatum; Frontal Lobe; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neural Pathways; Rats; Rats, Inbred Strains | 1989 |
Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Biological Transport; Calcium; Cell Survival; Cells, Cultured; Glutamates; Glutamic Acid; N-Methylaspartate; Neurons; Protein Kinase C; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1989 |
Transient increase of NMDA-binding sites in human hippocampus during development.
Topics: Adult; Aging; Aspartic Acid; Fetus; Glutamates; Glutamic Acid; Hippocampus; Humans; Infant; Infant, Newborn; Middle Aged; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Selective effects of serotonin upon excitatory amino acid-induced depolarizations of Purkinje cells in cerebellar slices from young rats.
Topics: Action Potentials; Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Rats, Inbred Strains; Serotonin | 1989 |
Developmental changes in the chemosensitivity of rat brain synaptoneurosomes to excitatory amino acids, estimated by inositol phosphate formation.
Topics: Aging; Animals; Aspartic Acid; Carbachol; Female; Frontal Lobe; Glutamates; Glutamic Acid; Inositol Phosphates; Male; N-Methylaspartate; Norepinephrine; Oxadiazoles; Quisqualic Acid; Rats; Sugar Phosphates; Synaptosomes | 1989 |
Glycine potentiates the stimulation of inositol phospholipid hydrolysis by excitatory amino acids in primary cultures of cerebellar neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Drug Synergism; Glutamates; Glutamic Acid; Glycine; Hydrolysis; Inositol Phosphates; Magnesium; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Signal Transduction; Sugar Phosphates | 1989 |
Delayed rescue of N-methyl-D-aspartate receptor-mediated neuronal injury in cortical culture.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Mice; N-Methylaspartate; Neurons; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Valine | 1989 |
Glutamate receptor activation in cultured cerebellar granule cells increases cytosolic free Ca2+ by mobilization of cellular Ca2+ and activation of Ca2+ influx.
Topics: Animals; Aspartic Acid; Benzofurans; Calcium; Calcium Channel Blockers; Cells, Cultured; Cerebellum; Cytosol; Fluorescent Dyes; Fura-2; Glutamates; Glutamic Acid; Inositol Phosphates; Kainic Acid; Mice; N-Methylaspartate; Receptors, Glutamate; Receptors, Neurotransmitter; Spectrometry, Fluorescence | 1989 |
Effects of excitant amino acids on acoustic responses of inferior colliculus neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Inferior Colliculi; N-Methylaspartate; Parasympathomimetics; Rats; Rats, Inbred Strains; Valine | 1989 |
Actions of excitatory amino acids on somatostatin release from cortical neurons in primary cultures.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Fetus; Glutamates; Glutamic Acid; Glutamine; Glycine; Kinetics; Magnesium; N-Methylaspartate; Neurons; Neurotransmitter Agents; Rats; Somatostatin; Tetrodotoxin; Veratridine | 1989 |
Lack of excitatory amino acid-induced effects on calcium fluxes measured with 45Ca2+ in rat cerebral cortex synaptosomes.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Calcium Radioisotopes; Cerebral Cortex; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Magnesium; Male; N-Methylaspartate; Potassium; Rats; Rats, Inbred Strains; Synaptosomes; Temperature | 1989 |
Extracellular taurine increase in rat hippocampus evoked by specific glutamate receptor activation is related to the excitatory potency of glutamate agonists.
Topics: Action Potentials; Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1989 |
Effects of amygdaloid kindling on NMDA receptor function and regulation.
Topics: Amygdala; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Glycine; Hippocampus; Kindling, Neurologic; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Multiple effects of phorbol esters in the rat spinal dorsal horn.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Calcium; Colforsin; Drug Synergism; Glutamates; Glutamic Acid; N-Methylaspartate; Neurons; Phorbol Esters; Rats; Rats, Inbred Strains; Sodium; Spinal Cord; Synapses; Synaptic Transmission | 1989 |
Inhibition of rat brain glutamate receptors by philanthotoxin.
Topics: Animals; Aspartic Acid; Bee Venoms; Brain; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Wasp Venoms; Xenopus | 1989 |
Dilator effects of amino acid neurotransmitters on piglet pial arterioles.
Topics: 6-Ketoprostaglandin F1 alpha; Amino Acids; Animals; Arteries; Arterioles; Aspartic Acid; Blood Pressure; Cerebrovascular Circulation; Dinoprostone; Female; Glutamates; Glutamic Acid; Glycine; Isoproterenol; Male; Muscle, Smooth, Vascular; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Pia Mater; Reference Values; Swine; Taurine | 1989 |
Glutamate receptors of the N-methyl-D-aspartate subtype in the myenteric plexus of the guinea pig ileum.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Guinea Pigs; Ileum; Magnesium; Male; Muscle Contraction; Myenteric Plexus; N-Methylaspartate; Piperazines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Different modulation of the binding to two phencyclidine (PCP) receptor subtypes: effects of N-methyl-D-aspartate agonists and antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Glutamates; Glutamic Acid; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1989 |
Different classes of glutamate receptors mediate distinct behaviors in a single brainstem nucleus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Brain Stem; Electric Fish; Electric Organ; Glutamates; Glutamic Acid; Glutamine; Kainic Acid; N-Methylaspartate; Oxadiazoles; Pipecolic Acids; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1989 |
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.
Topics: Animals; Arginine; Aspartic Acid; Cerebellum; Citrulline; Cyclic GMP; Glutamates; Glutamic Acid; Hemoglobins; In Vitro Techniques; Kainic Acid; Kinetics; N-Methylaspartate; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Quisqualic Acid; Rats | 1989 |
A biochemical correlate of the critical period for synaptic modification in the visual cortex.
Topics: Aging; Animals; Aspartic Acid; Carbachol; Cattle; Glutamates; Glutamic Acid; Ibotenic Acid; N-Methylaspartate; Ocular Physiological Phenomena; Phosphatidylinositols; Synapses; Vision, Ocular; Visual Cortex | 1989 |
Tonic activation of NMDA receptors by ambient glutamate enhances excitability of neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Algorithms; Animals; Aspartic Acid; Extracellular Space; Glutamates; Glutamic Acid; Hippocampus; Least-Squares Analysis; Magnesium; Microelectrodes; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1989 |
N-methyl-D-aspartate receptors in the cortex and hippocampus of baboon (Papio anubis and Papio papio).
Topics: Animals; Aspartic Acid; Binding, Competitive; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Hippocampus; N-Methylaspartate; Papio; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Selective inhibition of excitatory amino acids by divalent cations. A novel means for distinguishing N-methyl-D-aspartic acid-, kainate- and quisqualate-mediated actions in the mouse spinal cord.
Topics: Animals; Aspartic Acid; Behavior, Animal; Calcium; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; Male; Mice; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Spinal Cord; Zinc | 1989 |
Glial uptake of excitatory amino acids influences neuronal survival in cultures of mouse hippocampus.
Topics: Action Potentials; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Culture Media; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuroglia; Phosphopyruvate Hydratase; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Inhibition of N-methyl-D-aspartate (NMDA)- and L-glutamate-induced noradrenaline and acetylcholine release in the rat brain by ethanol.
Topics: Acetylcholine; Animals; Aspartic Acid; Calcium; Cerebral Cortex; Choline; Corpus Striatum; Ethanol; Glutamates; Glutamic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Tritium; Veratridine | 1989 |
Cerebellar granule cell survival and maturation induced by K+ and NMDA correlate with c-fos proto-oncogene expression.
Topics: Animals; Aspartic Acid; Cell Survival; Cerebellum; Glutamates; Glutamic Acid; Mice; N-Methylaspartate; Potassium; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Bicuculline- and phaclofen-sensitive components of N-methyl-D-aspartate-induced hyperpolarizations in rat dorsolateral septal nucleus neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Baclofen; Bicuculline; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Septal Nuclei; Tetrodotoxin | 1989 |
The effects of potassium channel blocking agents on the responses of in vitro frog motoneurones to glutamate and other excitatory amino acids: an intracellular study.
Topics: Amino Acids; Animals; Aspartic Acid; Cell Membrane; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Ion Channels; N-Methylaspartate; Oxadiazoles; Potassium; Quisqualic Acid; Rana temporaria; Spinal Cord | 1985 |
The action of N-methyl-D-aspartic acid on mouse spinal neurones in culture.
Topics: Action Potentials; Animals; Aspartic Acid; Cells, Cultured; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Spinal Cord; Time Factors | 1985 |
Excitatory amino acid-induced responses of frog motoneurones bathed in low Na+ media: an intracellular study.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Ion Channels; Membrane Potentials; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rana temporaria; Sodium; Spinal Cord | 1985 |
Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Corpus Callosum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Ketamine; Male; Muscimol; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Potassium; Quisqualic Acid; Rats; Rats, Inbred Strains; Tetrodotoxin | 1985 |
Roles of aspartate and glutamate in synaptic transmission in rabbit retina. I. Outer plexiform layer.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Neurotransmitter Agents; Rabbits; Retina; Synaptic Transmission | 1985 |
Effects of anti-glutamate-binding protein antibodies on synaptic membrane ion flux, glutamate transport and release, and L-glutamate binding activities.
Topics: Animals; Antibodies; Aspartic Acid; Biological Transport; Cattle; Glutamates; Glutamic Acid; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Sodium; Synaptic Membranes; Thiocyanates | 1985 |
Excitotoxin lesions suggest an aspartatergic projection from rat medial prefrontal cortex to ventral tegmental area.
Topics: Animals; Aspartic Acid; Efferent Pathways; Frontal Lobe; Glutamates; Glutamic Acid; N-Methylaspartate; Rats; Synaptic Transmission; Tegmentum Mesencephali | 1985 |
Excitatory effects of L-glutamate and some analogs on isolated horizontal cells from the catfish retina.
Topics: Animals; Aspartic Acid; Fishes; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Retina | 1985 |
Anticonvulsant action of beta-kainic acid in mice. Is beta-kainic acid an N-methyl-D-aspartate antagonist?
Topics: Animals; Anticonvulsants; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Homocysteine; Kainic Acid; Mice; N-Methylaspartate; Oxadiazoles; Pyrrolidines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Seizures; Stereoisomerism | 1985 |
Effects of excitatory amino acids on calcium transport by brain membranes.
Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport, Active; Brain Chemistry; Calcium; Glutamates; Glutamic Acid; Kainic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Neurotransmitter Agents; Synaptosomes | 1985 |
Calcium influx accompanies but does not cause excitotoxin-induced neuronal necrosis in retina.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Aspartic Acid; Calcium; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Mice; N-Methylaspartate; Necrosis; Nicotinic Acids; Nimodipine; Pyrrolidines; Retina | 1985 |
Anticonvulsant properties of 3-hydroxy-2-quinoxalinecarboxylic acid, a newly found antagonist of excitatory amino acids.
Topics: Animals; Anticonvulsants; Aspartic Acid; Electroencephalography; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Picrotoxin; Pyrrolidines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Structure-Activity Relationship | 1985 |
Pharmacological characterization of postsynaptic receptors for excitatory amino acids in Purkinje cell dendrites in the guinea pig cerebellum.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Dendrites; Dipeptides; Drug Synergism; Glutamates; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Purkinje Cells; Receptors, Neurotransmitter | 1985 |
Synaptic transmission between dorsal root ganglion and dorsal horn neurons in culture: antagonism of monosynaptic excitatory postsynaptic potentials and glutamate excitation by kynurenate.
Topics: Animals; Aspartic Acid; Cells, Cultured; Evoked Potentials; Female; Ganglia, Spinal; Glutamates; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Pregnancy; Rats; Spinal Cord; Synaptic Transmission | 1985 |
L-[3H]Glutamate binds to kainate-, NMDA- and AMPA-sensitive binding sites: an autoradiographic analysis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Binding Sites; Brain; Brain Chemistry; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1985 |
Effects of bath-applied excitatory amino acids and their analogs on spinal interneurons of the lamprey.
Topics: Amino Acids; Animals; Aspartic Acid; Fishes; Glutamates; Glutamic Acid; Glycine; Homocysteine; In Vitro Techniques; Interneurons; Kainic Acid; Lampreys; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Spinal Cord | 1985 |
L-Homocysteic acid as an alternative cytotoxin for studying glutamate-induced cellular degeneration of Huntington's disease and normal skin fibroblasts.
Topics: Aspartic Acid; Cell Survival; Cells, Cultured; Cysteic Acid; Cysteine; Fibroblasts; Glutamates; Glutamic Acid; Homocysteine; Humans; Huntington Disease; In Vitro Techniques; Isomerism; Kainic Acid; Kinetics; N-Methylaspartate; Neurotransmitter Agents; Skin; Time Factors | 1985 |
Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain.
Topics: Animals; Aspartic Acid; Autoradiography; Binding Sites; Brain; Glutamates; Glutamic Acid; Kinetics; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tissue Distribution | 1985 |
Peptides derived from kainic acid as antagonists of N-methyl-D-aspartate-induced neuroexcitation in rat brain.
Topics: Animals; Aspartic Acid; Corpus Striatum; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats | 1985 |
Excitatory and inhibitory responses of Purkinje cells, in the rat cerebellum in vivo, induced by excitatory amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Calcium and unit response decrement to locally applied glutamate on rat hippocampal CA1 neurons.
Topics: Animals; Aspartic Acid; Calcium; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Iontophoresis; Male; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains | 1985 |
A dipeptide derived from kainic and L-glutamic acids: a selective antagonist of amino acid induced neuroexcitation with anticonvulsant properties.
Topics: Animals; Aspartic Acid; Cell Membrane Permeability; Corpus Striatum; Dipeptides; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Oxadiazoles; Picrotoxin; Quisqualic Acid; Rats; Seizures; Sodium | 1985 |
The role of putative excitatory amino acid neurotransmitters in the initiation of locomotion in the lamprey spinal cord. II. The effects of amino acid uptake inhibitors.
Topics: Amino Acids; Animals; Aspartic Acid; Fishes; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Lampreys; Locomotion; N-Methylaspartate; Neurotransmitter Agents; Spinal Cord; Synaptic Transmission | 1985 |
Kynurenic acid and quinolinic acid act at N-methyl-D-aspartate receptors in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1986 |
Action of excitatory amino acids and their antagonists on hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Guinea Pigs; Hippocampus; Iontophoresis; Manganese; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Tetrodotoxin; Valine | 1985 |
Induction of glutamate binding sites in hippocampal membranes by transient exposure to high concentrations of glutamate or glutamate analogs.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Aminobutyrates; Animals; Aspartic Acid; Binding Sites; Chlorides; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Kinetics; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Saponins; Sodium; Valine | 1986 |
An excitatory amino acid projection from rat prefrontal cortex to periaqueductal gray.
Topics: Animals; Aspartic Acid; Frontal Lobe; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Necrosis; Neurotransmitter Agents; Periaqueductal Gray; Rats; Rats, Inbred Strains; Synaptosomes | 1986 |
A magnesium-sensitive post-synaptic potential in rat cerebral cortex resembles neuronal responses to N-methylaspartate.
Topics: Action Potentials; Animals; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Neurons; Rats; Sensory Thresholds; Synapses | 1986 |
Comparison of responses to transmitter candidates at an N-methylaspartate receptor mediated synapse, in slices of rat cerebral cortex.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Cysteic Acid; Cysteine; Glutamates; Glutamic Acid; Magnesium; Male; N-Methylaspartate; Neurotransmitter Agents; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission | 1986 |
Effects of topically applied excitatory amino acids on evoked potentials and single cell activity in rat cerebral cortex.
Topics: Administration, Topical; Amino Acids; Animals; Aspartic Acid; Carbachol; Cerebral Cortex; Evoked Potentials, Somatosensory; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tetrodotoxin | 1986 |
N-methyl D-aspartate acts as an antagonist of the photoreceptor transmitter in the carp retina.
Topics: Animals; Aspartic Acid; Carps; Glutamates; Glutamic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neural Inhibition; Neurotransmitter Agents; Photic Stimulation; Photoreceptor Cells; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina | 1986 |
Pharmacologically distinct glutamate receptors on cerebellar granule cells.
Topics: 2-Aminoadipic Acid; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Isomerism; Kainic Acid; Kinetics; Mice; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1986 |
A comparative study on the elicitability of vocalization by electrical brain stimulation, glutamate, aspartate and quisqualate in the squirrel monkey.
Topics: Animals; Aspartic Acid; Brain Mapping; Electric Stimulation; Evoked Potentials; Glutamates; Glutamic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Reaction Time; Saimiri; Vocalization, Animal | 1986 |
The presence of N-methyl-D-aspartate-type receptors for glutamic acid in the guinea pig myenteric plexus.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscles; Myenteric Plexus; N-Methylaspartate; Receptors, Glutamate; Receptors, Neurotransmitter | 1986 |
Role of excitatory amino acid transmission in the genesis of seizures elicited from the deep prepiriform cortex.
Topics: Animals; Aspartic Acid; Bicuculline; Carbachol; Glutamates; Glutamic Acid; Kainic Acid; Limbic System; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Seizures | 1986 |
Receptors for excitatory amino acids on neurons in rat pyriform cortex.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Limbic System; N-Methylaspartate; Olfactory Pathways; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Neurotransmitter; Synaptic Transmission | 1986 |
Chemoresponsiveness of intracellular nuclei neurones to L-aspartate, L-glutamate and related derivatives in rat cerebellar slices maintained in vitro.
Topics: Animals; Aspartic Acid; Cerebellar Nuclei; Convulsants; Glutamates; Glutamic Acid; In Vitro Techniques; Injections; Magnesium; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
Comparative actions of quisqualate and N-methyl-D-aspartate, excitatory amino acid agonists, on guinea-pig cochlear potentials.
Topics: Action Potentials; Animals; Aspartic Acid; Cochlea; Dose-Response Relationship, Drug; Evoked Potentials; Glutamates; Glutamic Acid; Guinea Pigs; Kainic Acid; Kinetics; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Vestibulocochlear Nerve | 1986 |
Respiratory motoneuronal activity is altered by injections of picomoles of glutamate into cat brain stem.
Topics: Animals; Aspartic Acid; Blood Pressure; Brain Stem; Cats; Dose-Response Relationship, Drug; Electrophysiology; Glutamates; Glutamic Acid; Homocysteine; Microchemistry; Motor Neurons; N-Methylaspartate; Respiration | 1986 |
Characterization of the inhibition of excitatory amino acid-induced neurotransmitter release in the rat striatum by phencyclidine-like drugs.
Topics: Animals; Aspartic Acid; Corpus Striatum; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Kainic Acid; Magnesium; Male; N-Methylaspartate; Neurotransmitter Agents; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1986 |
Neurons containing NADPH-diaphorase are selectively resistant to quinolinate toxicity.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Humans; Huntington Disease; Kainic Acid; Mice; N-Methylaspartate; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; Neurons; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid | 1986 |
Action of 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP): a new and highly potent antagonist of N-methyl-D-aspartate receptors in the hippocampus.
Topics: Animals; Aspartic Acid; Cell Membrane; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kinetics; N-Methylaspartate; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1986 |
Localization of [3H]glutamate binding sites in rat adrenal medulla.
Topics: Acetates; Acetic Acid; Adrenal Medulla; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Cerebral Cortex; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Organ Specificity; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains | 1986 |
Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Autoradiography; Female; Glutamates; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Male; Middle Aged; N-Methylaspartate; Neuronal Plasticity; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission | 1986 |
Cellular origins of cyclic GMP responses to excitatory amino acid receptor agonists in rat cerebellum in vitro.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Drug Interactions; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Nitroprusside; Purkinje Cells; Rats; Tetrodotoxin | 1987 |
Dementia of the Alzheimer's type: changes in hippocampal L-[3H]glutamate binding.
Topics: Alzheimer Disease; Aspartic Acid; Autoradiography; Flunitrazepam; Glutamates; Glutamic Acid; Hippocampus; Histocytochemistry; Humans; Muscimol; N-Methylaspartate; Receptors, GABA-A; Receptors, Muscarinic; Tissue Distribution | 1987 |
Magnesium ions inhibit the stimulation of inositol phospholipid hydrolysis by endogenous excitatory amino acids in primary cultures of cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Drug Synergism; Glutamates; Glutamic Acid; Hydrolysis; Inositol Phosphates; Kainic Acid; Magnesium; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Sugar Phosphates; Valine; Veratridine | 1987 |
Solubilization of novel binding sites for [3H]glutamate in rat adrenal.
Topics: Adrenal Glands; Animals; Aspartic Acid; Detergents; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Solubility | 1987 |
Aortic baroreceptor reflexes are mediated by NMDA receptors in caudal ventrolateral medulla.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aorta; Aspartic Acid; Electric Stimulation; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Injections, Intraventricular; Medulla Oblongata; Microinjections; N-Methylaspartate; Pressoreceptors; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reflex; Synaptic Transmission; Valine | 1987 |
Comparison of L-[3H]glutamate, D-[3H]aspartate, DL-[3H]AP5 and [3H]NMDA as ligands for NMDA receptors in crude postsynaptic densities from rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Brain; Brain Chemistry; Chemical Phenomena; Chemistry; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1987 |
CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo.
Topics: Acetylcholine; Animals; Aspartic Acid; Cerebellum; Corpus Striatum; Cyclic GMP; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1987 |
Enhancement of [3H]glutamate binding by N-methyl-D-aspartic acid in rat adrenal.
Topics: Adrenal Glands; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Male; Membranes; Molecular Conformation; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Sodium; Stimulation, Chemical | 1987 |
Identification and characterization of an N-methyl-D-aspartate-specific L-[3H]glutamate recognition site in synaptic plasma membranes.
Topics: Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Ions; Kinetics; Male; N-Methylaspartate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Synaptic Membranes; Temperature; Time Factors | 1987 |
Cytoplasmic calcium elevation in hippocampal granule cell induced by perforant path stimulation and L-glutamate application.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Anticonvulsants; Aspartic Acid; Benzofurans; Calcium; Cytoplasm; Egtazic Acid; Electric Stimulation; Fluorescent Dyes; Fura-2; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; N-Methylaspartate; Neural Pathways; Tetrodotoxin; Valine | 1987 |
The effects of prolonged superfusions with acidic amino acids and their agonists on field potentials and horizontal cell photoresponses in the turtle retina.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; Membrane Potentials; N-Methylaspartate; Perfusion; Photoreceptor Cells; Retina; Turtles | 1987 |
The novel anticonvulsant MK-801 binds to the activated state of the N-methyl-D-aspartate receptor in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Membranes; Valine | 1987 |
Evidence for a direct action of N-methylaspartate on non-neuronal cells.
Topics: Amino Acids; Animals; Aspartic Acid; Cell Survival; Dialysis; Ethanolamines; Extracellular Space; Glutamates; Glutamic Acid; Glutamine; Hippocampus; Male; N-Methylaspartate; Neuroglia; Purines; Rats; Rats, Inbred Strains; Taurine | 1987 |
Postnatal development of the chemosensitivity of rat cerebellar Purkinje cells to excitatory amino acids. An in vitro study.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cerebellar Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Rats, Inbred Strains; Reaction Time; Valine | 1987 |
Excitatory amino acid receptor potency and subclass specificity of sulfur-containing amino acids.
Topics: Amino Acids, Sulfur; Aminobutyrates; Animals; Aspartic Acid; Brain; Chick Embryo; Glutamates; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Sodium; Synaptic Membranes | 1987 |
L-glutamate and N-methyl-D-asparatate actions on membrane potential and conductance of cat abducens motoneurones.
Topics: Abducens Nerve; Action Potentials; Animals; Aspartic Acid; Cats; Electric Conductivity; Glutamates; Glutamic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neural Conduction | 1987 |
[3H]norepinephrine release from hippocampal slices is an in vitro biochemical tool for investigating the pharmacological properties of excitatory amino acid receptors.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Glutamates; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Tetrodotoxin | 1987 |
Hippocampal cells primed with quisqualate are depolarized by AP4 and AP6, ligands for a putative glutamate uptake site.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Aminocaproates; Animals; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Norleucine; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1987 |
Glutamate-induced ionic currents in cultured neurons from the rat superior colliculus.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Glutamates; Glutamic Acid; Magnesium; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Superior Colliculi | 1987 |
Amino acid influences on seizures elicited within the inferior colliculus.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Inferior Colliculi; Male; Muscimol; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Taurine | 1987 |
Autoradiographic localization of cerebellar excitatory amino acid binding sites in the mouse.
Topics: Animals; Aspartic Acid; Autoradiography; Binding Sites; Cerebellum; Glutamates; Glutamic Acid; Kainic Acid; Mice; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface | 1987 |
Lesions of putative glutamatergic pathways potentiate the increase of inositol phospholipid hydrolysis elicited by excitatory amino acids.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Colchicine; Corpus Striatum; Glutamates; Glutamic Acid; Hippocampus; Hydrolysis; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1987 |
L-homocysteic acid: an endogenous excitotoxic ligand of the NMDA receptor.
Topics: Animals; Aspartic Acid; Binding, Competitive; Brain; Chick Embryo; Glutamates; Glutamic Acid; Homocysteine; Kainic Acid; Ligands; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina | 1987 |
L-homocysteic acid but not L-glutamate is an endogenous N-methyl-D-aspartic acid receptor preferring agonist in rat neocortical neurons in vitro.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Isomerism; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Oxadiazoles; Quisqualic Acid; Valine | 1988 |
Differential effects of serotonin on the spontaneous discharge and on the excitatory amino acid-induced responses of deep cerebellar nuclei neurons in rat cerebellar slices.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Calcium; Cerebellar Nuclei; Drug Interactions; Glutamates; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Oxadiazoles; Potassium; Quisqualic Acid; Rats; Rats, Inbred Strains; Serotonin | 1987 |
Fictive locomotion in the lamprey; a comparison using bicarbonate and HEPES buffers.
Topics: Animals; Aspartic Acid; Bicarbonates; Buffers; Fishes; Glutamates; Glutamic Acid; HEPES; Lampreys; Locomotion; N-Methylaspartate; Spinal Cord | 1988 |
Excitatory amino acid-evoked membrane currents and excitatory synaptic transmission in lamprey reticulospinal neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Stem; Electric Stimulation; Evoked Potentials; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Lampreys; N-Methylaspartate; Neurons; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Spinal Cord; Synapses; Synaptic Transmission | 1988 |
Utilization of the synthetic phosphagen cyclocreatine phosphate by a simple brain model during stimulation by neuroexcitatory amino acids.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Chick Embryo; Glutamates; Glutamic Acid; Homocysteine; Imidazolidines; Kainic Acid; Magnesium; N-Methylaspartate; Phosphocreatine | 1988 |
Enhancement of the oxygen consumption in the hippocampal slices of the guinea pig induced by glutamate and its related substances.
Topics: Action Potentials; Animals; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Oxygen Consumption | 1988 |
The modulation of excitatory amino acid responses by serotonin in the cat neocortex in vitro.
Topics: Animals; Aspartic Acid; Cats; Cerebral Cortex; Cinanserin; Electric Stimulation; Evoked Potentials; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Magnesium; Male; Membrane Potentials; Methysergide; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Serotonin; Tetraethylammonium Compounds; Tetrodotoxin | 1987 |
Solubilization of rat brain phencyclidine receptors in an active binding form that is sensitive to N-methyl-D-aspartate receptor ligands.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Brain Chemistry; Cell Membrane; Cholic Acid; Cholic Acids; Detergents; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Solubility; Valine | 1988 |
Inhibition by forskolin of excitatory amino acid-induced accumulation of cyclic AMP in guinea pig hippocampal slices.
Topics: Adenosine; Amino Acids; Animals; Aspartic Acid; Chlorides; Colforsin; Cyclic AMP; Cysteine; Drug Interactions; Ethylmaleimide; Glutamates; Glutamic Acid; Guanosine Triphosphate; Guinea Pigs; Hippocampus; Histamine; Male; N-Methylaspartate; Neurotransmitter Agents; Veratridine | 1988 |
CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.
Topics: Acetylcholine; Aconitine; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Binding, Competitive; Darkness; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Structure-Activity Relationship; Tetrodotoxin | 1988 |
L-glutamate-induced depolarization in solitary photoreceptors: a process that may contribute to the interaction between photoreceptors in situ.
Topics: Animals; Aspartic Acid; Axons; Dose-Response Relationship, Drug; Electric Conductivity; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Photoreceptor Cells; Quisqualic Acid; Sodium; Turtles | 1988 |
Maturational changes in retinal excitatory amino acid receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding, Competitive; Chick Embryo; Embryonic and Fetal Development; Glutamates; Glutamic Acid; Ibotenic Acid; Kinetics; N-Methylaspartate; Receptors, Amino Acid; Receptors, Cell Surface; Retina | 1988 |
Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801.
Topics: Animals; Anticonvulsants; Aspartic Acid; Calcium; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; N-Methylaspartate; Rats; Retina; Retinal Ganglion Cells | 1988 |
Focal cerebral ischaemia in the cat: treatment with the glutamate antagonist MK-801 after induction of ischaemia.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain Ischemia; Cats; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate | 1988 |
Phorbol esters attenuate glutamate-stimulated inositol phospholipid hydrolysis in neuronal cultures.
Topics: Animals; Aspartic Acid; Carbachol; Cerebellum; Diglycerides; Glutamates; Glutamic Acid; Hydrolysis; Inositol Phosphates; N-Methylaspartate; Neurons; Oxadiazoles; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Sphingosine; Tetradecanoylphorbol Acetate | 1988 |
An intracellular analysis of amino acid induced excitations of deep dorsal horn neurones in the rat spinal cord slice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; In Vitro Techniques; Intracellular Membranes; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Spinal Cord; Tetrodotoxin; Valine | 1988 |
Glutamate stimulates somatostatin release from diencephalic neurons in primary culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Diencephalon; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Oxadiazoles; Phencyclidine; Potassium; Quisqualic Acid; Rats; Somatostatin; Tetrodotoxin; Valine; Veratridine | 1988 |
Pharmacological induction of use-dependent receptive field modifications in the visual cortex.
Topics: Acetylcholine; Animals; Aspartic Acid; Cats; Glutamates; Glutamic Acid; N-Methylaspartate; Neuronal Plasticity; Neurons; Norepinephrine; Photic Stimulation; Reference Values; Vision, Ocular; Visual Cortex | 1988 |
Transient increased density of NMDA binding sites in the developing rat hippocampus.
Topics: Aging; Animals; Aspartic Acid; Autoradiography; Binding, Competitive; Glutamates; Glutamic Acid; Hippocampus; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Behavioral classification of excitatory amino acid receptors in mouse spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Behavior, Animal; Glutamates; Glutamic Acid; Glutamine; Kainic Acid; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord; Valine | 1988 |
Tetrahydroaminoacridine selectively attenuates NMDA receptor-mediated neurotoxicity.
Topics: Aminoacridines; Animals; Aspartic Acid; Cells, Cultured; Cholinesterase Inhibitors; Glutamates; Glutamic Acid; Mice; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tacrine | 1988 |
Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine.
Topics: Animals; Aspartic Acid; Autoradiography; Binding Sites; Brain; Glutamates; Glutamic Acid; Glycine; Male; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Effects of pharmacological manipulations on basal and newly synthesized levels of GABA, glutamate, aspartate and glutamine in mouse brain cortex.
Topics: 2-Amino-5-phosphonovalerate; 3-Mercaptopropionic Acid; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Male; Mice; N-Methylaspartate; Valproic Acid | 1988 |
Epinephrine and norepinephrine modulate neuronal responses to excitatory amino acids and agonists in frog spinal cord.
Topics: Amino Acids; Animals; Aspartic Acid; Epinephrine; Glutamates; Glutamic Acid; In Vitro Techniques; Isoproterenol; Kainic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Norepinephrine; Oxadiazoles; Quisqualic Acid; Rana pipiens; Reference Values; Spinal Cord; Yohimbine | 1987 |
Properties of two classes of rat brain acidic amino acid receptors induced by distinct mRNA populations in Xenopus oocytes.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Glycine; Kainic Acid; N-Methylaspartate; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; RNA, Messenger; Xenopus laevis | 1988 |
Phosphonate analogues of carboxylic acids as aminoacid antagonists on rat cortical neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Drug Antagonism; Electric Conductivity; Glutamates; Glutamic Acid; Isomerism; Kainic Acid; N-Methylaspartate; Neurons; Organophosphorus Compounds; Rats; Valine | 1981 |
Stimulation of rat cerebellar guanosine 3',5'-cyclic monophosphate (cyclic GMP) levels: effects of amino acid antagonists.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cerebellum; Cyclic GMP; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; N-Methylaspartate; Protoveratrines; Rats; Rats, Inbred Strains | 1981 |
Specific and non-specific effects of neuro-excitatory amino acids on learning and other behaviours in the chicken.
Topics: Aggression; Aging; Animals; Aspartic Acid; Behavior, Animal; Chickens; Copulation; Glutamates; Glutamic Acid; Habituation, Psychophysiologic; Humans; Kainic Acid; Learning; N-Methylaspartate; Pattern Recognition, Visual; Pyrrolidines; Visual Perception | 1982 |
The action of six antagonists of the excitatory amino acids on neurones of the rat spinal cord.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Rats; Spinal Cord; Structure-Activity Relationship | 1982 |
Activity of the enantiomers of 2-amino-5-phosphono-valeric acid as stereospecific antagonists of excitatory aminoacids.
Topics: Adipates; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Dose-Response Relationship, Drug; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Rats; Stereoisomerism; Synaptic Transmission | 1981 |
2-amino-4-phosphonobutyric acid and N-methyl-D-aspartate differentiate between "3H]glutamate and [3H] aspartate binding sites in bovine retina.
Topics: Aminobutyrates; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Cattle; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; N-Methylaspartate; Neurons; Retina; Synaptic Membranes | 1982 |
Conductance changes induced by DL-homocysteic acid and N-methyl-DL-aspartic acid in hippocampal neurons.
Topics: Animals; Aspartic Acid; Cell Membrane; Electric Conductivity; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Homocysteine; In Vitro Techniques; Iontophoresis; Manganese; N-Methylaspartate; Tetrodotoxin | 1982 |
Effect of urethane on synaptic and amino acid-induced excitation in isolated spinal cord preparations.
Topics: Animals; Aspartic Acid; Evoked Potentials; Ganglia, Spinal; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Ranidae; Rats; Spinal Cord; Synapses; Urethane | 1982 |
Characterization of the excitatory amino acid receptor-mediated release of [3H]acetylcholine from rat striatal slices.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Afferent Pathways; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Interneurons; Magnesium; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Valine | 1982 |
Excitatory amino acid receptors and guanosine 3',5'-cyclic monophosphate in incubated slices of immature and adult rat cerebellum.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Rats; Receptors, Amino Acid; Receptors, Cell Surface | 1982 |
Effects of D-alpha-aminoadipate on excitation of afferent fibers in the lateral line of Xenopus laevis.
Topics: 2-Aminoadipic Acid; Afferent Pathways; Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Female; Glutamates; Glutamic Acid; Hair Cells, Auditory; Kainic Acid; Male; Mechanoreceptors; Motor Activity; N-Methylaspartate; Synaptic Transmission; Xenopus laevis | 1982 |
Selective antagonist activity of 5-aminohex-2-enedioic acid on amino acid excitation of cat spinal neurones.
Topics: 2-Aminoadipic Acid; Amino Acids; Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Cats; Glutamates; Glutamic Acid; Interneurons; N-Methylaspartate; Neurons; Spinal Cord; Structure-Activity Relationship | 1980 |
Kainate, N-methylaspartate and other excitatory amino acids increase calcium influx into rat brain cortex cells in vitro.
Topics: Absorption; Amino Acids; Animals; Aspartic Acid; Calcium; Cerebral Cortex; Glutamates; Glutamic Acid; Homocysteine; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Rats | 1983 |
Presence of N-methyl-D-aspartate-like and kainate-like activities in bovine brain.
Topics: Animals; Aspartic Acid; Brain Chemistry; Carbon Radioisotopes; Cattle; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Pyrrolidines | 1983 |
Excitatory amino acids: modes of action on hippocampal pyramidal cells.
Topics: Action Potentials; Animals; Aspartic Acid; Calcium; Electric Conductivity; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Ion Channels; Membrane Potentials; N-Methylaspartate; Potassium; Receptors, Cell Surface; Receptors, Glutamate; Synapses | 1983 |
Neuroactive amino acids influence gonadotrophin output by a suprapituitary mechanism in either rodents or primates.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Luteinizing Hormone; Macaca fascicularis; Macaca nemestrina; Male; N-Methylaspartate; Papio; Rats; Rats, Inbred Strains | 1983 |
Effects of excitatory amino acids on locomotor activity after bilateral microinjection into the rat nucleus accumbens: possible dependence on dopaminergic mechanisms.
Topics: Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Nucleus Accumbens; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Seizures; Septal Nuclei; Synaptic Transmission | 1983 |
Effects of excitatory amino acids on dopamine synthesis in the rat retina.
Topics: Amino Acids; Animals; Aspartic Acid; Dopamine; Glutamates; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Retina | 1983 |
Voltage clamp analysis of the effect of excitatory amino acids and derivatives on Purkinje cell dendrites in rat cerebellar slices maintained in vitro.
Topics: Amino Acids; Animals; Aspartic Acid; Culture Techniques; Dendrites; Glutamates; Glutamic Acid; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Synaptic Transmission | 1983 |
Effects of kainic and other amino acids on synaptic excitation in rat hippocampal slices: 1. Extracellular analysis.
Topics: Amino Acids; Animals; Aspartate Aminotransferases; Aspartic Acid; Evoked Potentials; Folic Acid; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neural Pathways; Oxadiazoles; Pyrrolidines; Quisqualic Acid; Rats | 1983 |
N-methyl aspartate activates voltage-dependent calcium conductance in rat hippocampal pyramidal cells.
Topics: Action Potentials; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Ion Channels; N-Methylaspartate; Neural Conduction; Neurons; Potassium; Rats | 1983 |
Effects of excitatory amino acids, and of their agonists and antagonists on the release of neurotransmitters from the chick retina.
Topics: Amino Acids; Animals; Aspartic Acid; Chickens; Cysteic Acid; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Endings; Neurotransmitter Agents; Receptors, Neurotransmitter; Retina; Synapses; Synaptic Transmission | 1983 |
Differential sensitivity of selected brain areas to excitatory amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Rats; Sodium; Stimulation, Chemical | 1983 |
On the sensitivity of H1 horizontal cells of the carp retina to glutamate, aspartate and their agonists.
Topics: Animals; Aspartic Acid; Carps; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Retina | 1984 |
l-Glutamate reduces the affinity of [3H]N-propylnorapomorphine binding sites in striatal membranes.
Topics: Animals; Antiparkinson Agents; Apomorphine; Aspartic Acid; Binding Sites; Cell Membrane; Corpus Striatum; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Spiperone | 1984 |
Effect of excitatory amino acids on Purkinje cell dendrites in cerebellar slices from normal and staggerer mice.
Topics: Amino Acids; Animals; Aspartic Acid; Crosses, Genetic; Dendrites; Glutamates; Glutamic Acid; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Neurologic Mutants; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid | 1984 |
Mixed-agonist action of excitatory amino acids on mouse spinal cord neurones under voltage clamp.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Culture Techniques; Electric Conductivity; Glutamates; Glutamic Acid; Homocysteine; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Spinal Cord; Valine | 1984 |
The effect of D-alpha-aminoadipate on excitatory amino acid responses recorded intracellularly from motoneurones of the frog spinal cord.
Topics: 2-Aminoadipic Acid; Amino Acids; Amino Acids, Dicarboxylic; Animals; Anterior Horn Cells; Aspartic Acid; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rana temporaria; Spinal Nerve Roots | 1984 |
Selective association of N-methyl aspartate and quisqualate types of L-glutamate receptor with brain postsynaptic densities.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Chlorides; Glutamates; Glutamic Acid; Kinetics; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Synaptic Membranes | 1984 |
Arginine-vasopressin enhances the responses of lateral septal neurons in the rat to excitatory amino acids and fimbria-fornix stimuli.
Topics: Amino Acids; Animals; Arginine Vasopressin; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Muscimol; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Synapses | 1984 |
Evidence that inhibitory mechanisms mask inappropriate somatotopic connections in the spinal cord of normal rat.
Topics: Afferent Pathways; Animals; Electric Stimulation; Evoked Potentials, Somatosensory; Glutamic Acid; Glycine; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; Strychnine; Time Factors | 1995 |
Hypoxia, excitotoxicity, and neuroprotection in the hippocampal slice preparation.
Topics: Animals; Dose-Response Relationship, Drug; Excitatory Amino Acids; Glutamic Acid; Hippocampus; Hypoxia; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1995 |
L-glutamate-induced changes in intracellular calcium oscillation frequency through non-classical glutamate receptor binding in cultured rat myocardial cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart; Intracellular Fluid; Kainic Acid; Myocardium; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1995 |
The iron component of sodium nitroprusside blocks NMDA-induced glutamate accumulation and intracellular Ca2+ elevation.
Topics: Animals; Calcium; Catalase; Cells, Cultured; Cerebellum; Ferrocyanides; Glutamic Acid; Iron; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Nitroprusside; Penicillamine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Structure-Activity Relationship; Superoxide Dismutase; Vasodilator Agents | 1995 |
Intrauterine hypoxia-ischemia increases N-methyl-D-aspartate-induced cGMP formation and glutamate accumulation in cultured rat cerebellar granule cells.
Topics: Animals; Arginine; Brain Ischemia; Cells, Cultured; Cerebellar Diseases; Chronic Disease; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Fetal Hypoxia; Gestational Age; Glutamic Acid; Hypoxia, Brain; Kainic Acid; N-Methylaspartate; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley | 1995 |
Glutamate regulation of GDNF gene expression in the striatum and primary striatal astrocytes.
Topics: Animals; Astrocytes; Cells, Cultured; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Immunohistochemistry; Kainic Acid; Male; N-Methylaspartate; Neostriatum; Nerve Growth Factors; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1995 |
Assessment of primary neuronal culture as a model for soman-induced neurotoxicity and effectiveness of memantine as a neuroprotective drug.
Topics: Acetylcholine; Animals; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Injections, Subcutaneous; L-Lactate Dehydrogenase; Lethal Dose 50; Male; Memantine; N-Methylaspartate; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures; Soman | 1995 |
Effects of N-methyl-D-aspartate (NMDA) on seasonal cycles of reproduction, body weight and pelage colour in the male Siberian hamster.
Topics: Analysis of Variance; Animals; Body Weight; Central Nervous System; Cricetinae; Gene Expression Regulation; Genes, fos; Glutamic Acid; Hair Color; Immunohistochemistry; Male; N-Methylaspartate; Phodopus; Photoperiod; Receptors, Glutamate; Reproduction; Seasons | 1995 |
Protective effect of riluzole on excitatory amino acid-mediated neurotoxicity in motoneuron-enriched cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Survival; Cells, Cultured; Central Nervous System Diseases; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Motor Neurons; N-Methylaspartate; Rats; Receptors, Amino Acid; Riluzole; Thiazoles | 1995 |
Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Brain; Brain Injuries; Cerebral Cortex; Glutamates; Glutamic Acid; Glutamine; Male; Microdialysis; Microinjections; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Serine | 1993 |
Gabapentin actions on ligand- and voltage-gated responses in cultured rodent neurons.
Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Calcium Channels; Cells, Cultured; Cerebral Cortex; Cyclohexanecarboxylic Acids; Fetus; Gabapentin; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Ion Channel Gating; Ion Channels; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Neurons, Afferent; Nodose Ganglion; Rats; Sodium Channels; Spinal Cord; Synapses | 1993 |
Brief calcium transients evoked by glutamate receptor agonists in rat dorsal horn neurons: fast kinetics and mechanisms.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cells, Cultured; Cycloleucine; Female; Glutamates; Glutamic Acid; Ion Channel Gating; Kainic Acid; Kinetics; Lanthanum; N-Methylaspartate; Neurons; Neurotoxins; Photometry; Potassium; Pregnancy; Presynaptic Terminals; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1993 |
Membrane currents evoked by excitatory amino acid agonists in ON bipolar cells of the mudpuppy retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Animals; Cadmium; Cell Membrane; Cobalt; Cycloleucine; Electrophysiology; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Necturus maculosus; Neurotransmitter Agents; Receptors, Amino Acid; Retina | 1993 |
Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Calcium; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; Glutamates; Glutamic Acid; Hippocampus; Homeostasis; Kinetics; Lymphotoxin-alpha; N-Methylaspartate; Neurons; Neurotoxins; Rats; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha | 1994 |
Glutamate-evoked release of arachidonic acid from mouse brain astrocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Astrocytes; Brain; Cells, Cultured; Cerebellum; Cerebral Cortex; Corpus Striatum; Cycloleucine; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Kinetics; Mice; N-Methylaspartate; Neurotoxins; Organ Specificity; Quisqualic Acid; Receptors, Glutamate; Time Factors; Tritium | 1994 |
Role of NO production in NMDA receptor-mediated neurotransmitter release in cerebral cortex.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cerebral Cortex; Glutamates; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Indazoles; Male; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Norepinephrine; omega-N-Methylarginine; Potassium Chloride; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1994 |
The lateral hypothalamus: a primary site mediating excitatory amino acid-elicited eating.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Feeding Behavior; Glutamates; Glutamic Acid; Hypothalamic Area, Lateral; Injections; Kainic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley | 1993 |
Dexamethasone potentiates NMDA receptor-mediated neuronal injury in the postnatal rat.
Topics: Aldosterone; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Autoradiography; Blood Glucose; Brain; Dexamethasone; Electron Transport Complex IV; Glutamates; Glutamic Acid; Kainic Acid; Metyrapone; N-Methylaspartate; Neurotransmitter Agents; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Excitatory amino acid antagonists protect cochlear auditory neurons from excitotoxicity.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Brain Ischemia; Cochlea; Cochlear Microphonic Potentials; Dendrites; Electrophysiology; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory, Inner; Male; N-Methylaspartate; Neurons, Afferent; Neurotransmitter Agents; Perfusion; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1994 |
Influence of excitatory amino acid receptor subtypes on the electrophysiological activity of dopaminergic and nondopaminergic neurons in rat substantia nigra.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dopamine; Electrophysiology; Glutamates; Glutamic Acid; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Substantia Nigra | 1994 |
The effect of experimental ischaemia and excitatory amino acid agonists on the GABA and serotonin immunoreactivities in the rabbit retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cycloleucine; Dextromethorphan; Eye Proteins; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamic Acid; Intraocular Pressure; Ischemia; Kainic Acid; Kynurenic Acid; Memantine; N-Methylaspartate; Oxygen; Potassium Cyanide; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Vessels; Serotonin | 1994 |
Glutamate receptor-driven activation of transcription factors in primary neuronal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Astrocytes; Base Sequence; Binding Sites; Cell Nucleus; Cell Survival; Cells, Cultured; Cycloleucine; Embryo, Mammalian; Gene Expression; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Mice; Molecular Sequence Data; N-Methylaspartate; Neurons; Proto-Oncogene Proteins; Proto-Oncogenes; Quisqualic Acid; Rats; Receptors, Glutamate; Transcription Factors | 1994 |
Possible role of glutamatergic neurotransmission in regulating ethanol-evoked brain ascorbate release.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ascorbic Acid; Brain Chemistry; Dicarboxylic Acids; Electrophysiology; Ethanol; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Injections, Intraventricular; Kainic Acid; Male; Microelectrodes; N-Methylaspartate; Neostriatum; Piperazines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1994 |
Effects of L-glutamate on the responses to nerve stimulation in rat isolated atria.
Topics: Adrenergic Fibers; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Atrial Function; Electric Stimulation; Female; Glutamates; Glutamic Acid; Heart Atria; Heart Rate; In Vitro Techniques; Kainic Acid; Male; Muscarinic Antagonists; N-Methylaspartate; Norepinephrine; Purinergic P1 Receptor Antagonists; Quinoxalines; Rats; Rats, Wistar | 1994 |
Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cell Line; Cycloleucine; Dizocilpine Maleate; Glioma; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Ion Channels; Kainic Acid; Kinetics; Magnesium Chloride; N-Methylaspartate; Neurotoxins; Pyrrolidinones; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Signal Transduction; Tumor Cells, Cultured | 1994 |
Neuroprotective effect of hypothermia in cortical cultures exposed to oxygen-glucose deprivation or excitatory amino acids.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Cold Temperature; Cytosol; Dizocilpine Maleate; Fetus; Glucose; Glutamic Acid; Glycine; Hypothermia, Induced; Kainic Acid; Kinetics; Mice; N-Methylaspartate; Neurons | 1994 |
Release of the nitric oxide precursor, arginine, from the thalamus upon sensory afferent stimulation, and its effect on thalamic neurons in vivo.
Topics: Afferent Pathways; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arginine; Glutamic Acid; Male; N-Methylaspartate; Neurons; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium; Rats; Rats, Wistar; Synaptic Transmission; Thalamus; Vibrissae | 1994 |
Complex correlation between excitatory amino acid-induced increase in the intracellular Ca2+ concentration and subsequent loss of neuronal function in individual neocortical neurons in culture.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Membrane; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acids; Fetus; Glutamic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Potassium Chloride; Quisqualic Acid | 1994 |
Resetting the biological clock: mediation of nocturnal circadian shifts by glutamate and NO.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biological Clocks; Circadian Rhythm; Glutamic Acid; In Vitro Techniques; Light; N-Methylaspartate; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Receptors, N-Methyl-D-Aspartate; Retina; Signal Transduction; Suprachiasmatic Nucleus | 1994 |
Propofol protects cultured rat hippocampal neurons against N-methyl-D-aspartate receptor-mediated glutamate toxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Phosphopyruvate Hydratase; Propofol; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 1994 |
Excitotoxicity of glutamate and four analogs in primary spinal cord cell cultures.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acridine Orange; Animals; Cell Death; Cells, Cultured; Dizocilpine Maleate; Ethidium; Glutamic Acid; Kainic Acid; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Quisqualic Acid; Spinal Cord; Staining and Labeling | 1994 |
Thyrotropin-releasing hormone enhances excitatory postsynaptic potentials in neocortical neurons of the rat in vitro.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Electric Stimulation; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission; Thyrotropin-Releasing Hormone | 1994 |
Potentiation of synaptic transmission in the rat hippocampal slice by exogenous L-glutamate and selective L-glutamate receptor subtype agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Evoked Potentials; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Hippocampus; In Vitro Techniques; Iontophoresis; N-Methylaspartate; Nerve Fibers; Neurotoxins; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Synapses; Synaptic Transmission | 1994 |
Early in vitro development of voltage- and transmitter-gated currents in GABAergic amacrine cells.
Topics: Animals; Autoradiography; Cells, Cultured; Cellular Senescence; Chick Embryo; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Interneurons; Ion Channel Gating; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Quisqualic Acid; Receptors, GABA; Receptors, Glutamate; Retina; Time Factors; Tritium | 1994 |
Nitric oxide does not mediate acute glutamate neurotoxicity, nor is it neuroprotective, in rat brain slices.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cerebellum; Excitatory Amino Acids; Glutamic Acid; Hippocampus; In Vitro Techniques; N-Methylaspartate; Nerve Degeneration; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Wistar | 1994 |
Glutamate spinal retrograde sensitization of primary sensory neurons associated with nociception.
Topics: Amino Acid Oxidoreductases; Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Spinal; Male; Morphine; N-Methylaspartate; Neurons, Afferent; Nitric Oxide Synthase; Nociceptors; Pain Measurement; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Spinal Cord; Vasodilator Agents | 1994 |
Aluminium reduces glutamate-activated currents of rat hippocampal neurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aluminum; Animals; Electric Conductivity; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Osmolar Concentration; Rats; Rats, Wistar | 1994 |
The role of free radicals in NMDA-dependent neurotoxicity.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Calcium; Cells, Cultured; Cerebellar Cortex; Cyclic GMP; Electron Spin Resonance Spectroscopy; Enzyme Activation; Epilepsy; Feedback; Free Radicals; Glutamic Acid; Guanylate Cyclase; Kindling, Neurologic; Mice; Molsidomine; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
Taurine release from mouse hippocampal slices: effects of glutamatergic substances and hypoxia.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Female; Glutamic Acid; Hippocampus; Kainic Acid; Male; Mice; N-Methylaspartate; Nitrogen; Oxygen; Potassium; Quisqualic Acid; Taurine | 1994 |
Intracerebral microdialysis combined with recording of extracellular field potential: a novel method for investigation of depolarizing drugs in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Polarity; Electroencephalography; Excitatory Amino Acids; Extracellular Space; Glutamic Acid; Kainic Acid; Male; Membrane Potentials; Microdialysis; N-Methylaspartate; Neostriatum; Rats; Rats, Sprague-Dawley | 1994 |
Calcium dependence of glutamate receptor-evoked alkaline shifts in hippocampus.
Topics: Alkalies; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Extracellular Space; Glutamic Acid; Hippocampus; In Vitro Techniques; N-Methylaspartate; Potassium; Rats; Receptors, Glutamate | 1994 |
Modulation of neuropeptide FF release from rat spinal cord slices by glutamate. Involvement of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Dizocilpine Maleate; Glutamic Acid; In Vitro Techniques; Iodine Radioisotopes; Male; Membranes; N-Methylaspartate; Neuropeptides; Neurotoxins; Oligopeptides; Radioimmunoassay; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1994 |
Exacerbation of NMDA, AMPA, and L-glutamate excitotoxicity by the succinate dehydrogenase inhibitor malonate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Brain Diseases; Dizocilpine Maleate; Drug Synergism; Glutamic Acid; Male; Malonates; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Succinate Dehydrogenase | 1995 |
Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Antibodies, Monoclonal; Cell Death; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acids; Fetus; Glutamic Acid; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Kainic Acid; Kinetics; N-Methylaspartate; Nerve Degeneration; Nerve Growth Factors; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sialoglycoproteins | 1995 |
A glutamate-activated chloride current in cone-driven ON bipolar cells of the white perch retina.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chloride Channels; Chlorides; Cycloleucine; Dendrites; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurotoxins; Patch-Clamp Techniques; Perches; Picrotoxin; Quinoxalines; Quisqualic Acid; Receptors, Metabotropic Glutamate; Retina; Retinal Cone Photoreceptor Cells; Strychnine | 1995 |
Dopamine enhances glutamate-activated currents in spinal motoneurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apomorphine; Base Sequence; Benzazepines; Chick Embryo; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA Primers; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression; Glutamic Acid; Ion Channels; Kainic Acid; Kinetics; Membrane Potentials; Molecular Sequence Data; Motor Neurons; N-Methylaspartate; Patch-Clamp Techniques; Polymerase Chain Reaction; Receptors, Dopamine D1; RNA, Messenger; Spinal Cord; Time Factors | 1995 |
AMPA receptor activation regulates the glutamate metabotropic receptor stimulated phosphatidylinositol turnover in human cerebral cortex slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adolescent; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Calcimycin; Cerebral Cortex; Child; Cycloleucine; Dizocilpine Maleate; Female; Glutamic Acid; Humans; Male; Middle Aged; N-Methylaspartate; Phosphatidylinositols; Quisqualic Acid; Receptors, AMPA; Receptors, Metabotropic Glutamate; Signal Transduction; Tetrodotoxin | 1995 |
Glia modulate the response of murine cortical neurons to excitotoxicity: glia exacerbate AMPA neurotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Communication; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Fetus; Glutamic Acid; Kinetics; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Neuroglia; Neurons; Neurotoxins | 1995 |
Neurotoxicity of acute glutamate transport blockade depends on coactivation of both NMDA and AMPA/Kainate receptors in organotypic hippocampal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Cell Differentiation; Dose-Response Relationship, Drug; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Neurotoxins; Organ Culture Techniques; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 1995 |
Delayed antagonism of calpain reduces excitotoxicity in cultured neurons.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Calpain; Cell Survival; Cells, Cultured; Cerebellum; Dipeptides; Enzyme Activation; Glutamic Acid; Hippocampus; Kainic Acid; Leucine; N-Methylaspartate; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Rats; Receptors, N-Methyl-D-Aspartate; Spectrin; Time Factors | 1995 |
Long-term enhancement of dopamine release by high frequency tetanic stimulation via a N-methyl-D-aspartate-receptor-mediated pathway in rat striatum.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dopamine; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Long-Term Potentiation; Male; N-Methylaspartate; Neostriatum; Nerve Endings; Potassium Chloride; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1995 |
Excitatory amino acid receptor ligands: asymmetric synthesis, absolute stereochemistry and pharmacology of (R)- and (S)-homoibotenic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Ligands; N-Methylaspartate; Radioligand Assay; Rats; Receptors, Glutamate; Stereoisomerism; Structure-Activity Relationship | 1995 |
GFAP-positive hippocampal astrocytes in situ respond to glutamatergic neuroligands with increases in [Ca2+]i.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Rats | 1995 |
Evidence for N-methyl-D-aspartate and AMPA subtypes of the glutamate receptor on substantia nigra dopamine neurons: possible preferential role for N-methyl-D-aspartate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dopamine; Glutamic Acid; Iontophoresis; Male; N-Methylaspartate; Neurons; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Substantia Nigra | 1995 |
Pressor responses to stimulation of non-NMDA receptors in the superficial laminae of the cat spinal cord.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Blood Pressure; Cats; Decerebrate State; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Microinjections; N-Methylaspartate; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Respiratory Mechanics; Spinal Cord | 1995 |
Dramatic effects of external alkalinity on neuronal calcium recovery following a short-duration glutamate challenge: the role of the plasma membrane Ca2+/H+ pump.
Topics: Animals; Brain; Calcium; Calcium-Transporting ATPases; Cell Membrane; Cells, Cultured; Glutamic Acid; Hippocampus; Hydrogen-Ion Concentration; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Sodium | 1995 |
Identification of functional ionotropic glutamate receptor proteins in pancreatic beta-cells and in islets of Langerhans.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibody Specificity; Cell Line; Cell Membrane; Female; Glutamic Acid; Immunoblotting; Insulin; Insulin Secretion; Islets of Langerhans; Kainic Acid; Molecular Sequence Data; N-Methylaspartate; Peptide Fragments; Rabbits; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Kainic Acid | 1995 |
Toxic NMDA-receptor activation occurs during recovery in a tissue culture model of ischemia.
Topics: Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Culture Techniques; Deoxyglucose; Dose-Response Relationship, Drug; Glutamic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurotoxins; Piperazines; Potassium Cyanide; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1995 |
Analysis of glutamate receptors in primary cultured neurons from fetal rat forebrain.
Topics: Animals; Animals, Newborn; Binding, Competitive; Cell Membrane; Cells, Cultured; Embryo, Mammalian; Female; Fetus; Glutamic Acid; Kinetics; N-Methylaspartate; Neurons; Onium Compounds; Organophosphorus Compounds; Potassium; Pregnancy; Prosencephalon; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Tritium | 1995 |
Alteration in the glial cell metabolism of glutamate by kainate and N-methyl-D-aspartate.
Topics: Animals; Arginine; Brain; Brain Chemistry; Glutamate-Ammonia Ligase; Glutamate-Cysteine Ligase; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neuroglia; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Phosphopyruvate Hydratase; Rats; Rats, Wistar | 1995 |
Ethanol inhibits NMDA-induced toxicity and trophism in cultured cerebellar granule cells.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; Chlorides; Culture Media; Ethanol; Glutamic Acid; Glycine; N-Methylaspartate; Neurons; Neurotoxins; Potassium; Rats; Rats, Wistar; Time Factors; Tropism | 1995 |
Vulnerability of medium spiny striatal neurons to glutamate: role of Na+/K+ ATPase.
Topics: Animals; Brain; Corpus Striatum; Dose-Response Relationship, Drug; Energy Metabolism; Glutamic Acid; Huntington Disease; N-Methylaspartate; Neurons; Ouabain; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase | 1995 |
NMDA-induced glutamate and aspartate release from rat cortical pyramidal neurones: evidence for modulation by a 5-HT1A antagonist.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Drug Synergism; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Molecular Probes; N-Methylaspartate; Piperazines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists | 1995 |
NMDA and non-NMDA receptors contribute to synaptic transmission between the medial geniculate body and the lateral nucleus of the amygdala.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amygdala; Animals; Electric Stimulation; Glutamic Acid; Male; Memory; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1995 |
Basic fibroblast growth factor selectively increases AMPA-receptor subunit GluR1 protein level and differentially modulates Ca2+ responses to AMPA and NMDA in hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Fibroblast Growth Factor 2; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1995 |
Calcium-dependent glutamate release during neuronal development and synaptogenesis: different involvement of omega-agatoxin IVA- and omega-conotoxin GVIA-sensitive channels.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cadmium; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Differentiation; Cells, Cultured; Fetus; Glutamic Acid; Glycine; Hippocampus; Kinetics; Magnesium; N-Methylaspartate; Neurons; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Rats; Receptors, N-Methyl-D-Aspartate; Spider Venoms; Synapses; Time Factors | 1995 |
Interaction between glutamate and GABA on 3H-noradrenaline release from rat hypothalamus.
Topics: Animals; Baclofen; Drug Interactions; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Hypothalamus; Kainic Acid; Male; N-Methylaspartate; Norepinephrine; Potassium; Rats; Rats, Sprague-Dawley; Tritium | 1995 |
Role of glutamate and glutamate receptors in memory function and Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Animals; Cognition; Cycloserine; Discrimination Learning; Entorhinal Cortex; Female; Glutamic Acid; Humans; Male; Memory; N-Methylaspartate; Rats; Receptors, Glutamate; Temporal Lobe | 1995 |
Transcriptional or translational inhibition blocks low dose NMDA-mediated cell death.
Topics: Animals; Cell Death; Cells, Cultured; Cycloheximide; Dactinomycin; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Protein Biosynthesis; Rats; Retinal Ganglion Cells; Transcription, Genetic | 1995 |
L-type Ca2+ channels mediate joint modulation by gamma-amino-butyric acid and glutamate of [Ca2+]i and neuropeptide secretion in immortalized gonadodropin-releasing hormone neurons.
Topics: Bicuculline; Calcium; Calcium Channels; Cell Line, Transformed; Cytoplasm; gamma-Aminobutyric Acid; Glutamic Acid; Gonadotropin-Releasing Hormone; Kainic Acid; Muscimol; N-Methylaspartate; Neurons; Neuropeptides; Potassium Chloride | 1995 |
Discriminative stimulus effects of excitatory amino acid agonists in rats.
Topics: Animals; Conditioning, Operant; Cysteine; Discrimination, Psychological; Dose-Response Relationship, Drug; Excitatory Amino Acids; Glutamic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley | 1995 |
Effects of D-amphetamine administration on the release of endogenous excitatory amino acids in the rat nucleus accumbens.
Topics: Amphetamine; Animals; Aspartic Acid; Excitatory Amino Acids; Glutamic Acid; Haloperidol; Injections, Intravenous; Male; N-Methylaspartate; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1995 |
Blockade of L-glutamate receptors in the rostral ventrolateral medulla contributes to ethanol-evoked impairment of baroreflexes in conscious rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Baroreflex; Blood Pressure; Ethanol; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Hemodynamics; Male; Medulla Oblongata; Microinjections; N-Methylaspartate; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1995 |
Activity-dependent responses of developing cochlear nuclear neurons to microionophoretically-applied amino acids.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Acoustic Stimulation; Action Potentials; Animals; Auditory Threshold; Bicuculline; Cats; Cochlear Nucleus; gamma-Aminobutyric Acid; Glutamic Acid; Iontophoresis; N-Methylaspartate; Neurons; Synaptic Transmission | 1995 |
Induction of neuronal apoptosis by excitotoxins associated with long-lasting increase of 12-O-tetradecanoylphorbol 13-acetate-responsive element-binding activity.
Topics: Animals; Apoptosis; Base Sequence; Binding Sites; Dizocilpine Maleate; DNA; Embryo, Mammalian; Excitatory Amino Acid Agonists; Glutamic Acid; Molecular Sequence Data; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tetradecanoylphorbol Acetate; Trans-Activators | 1995 |
Characterization of the excitoprotective actions of N-methyl-D-aspartate in cultured cerebellar granule neurons.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; Cycloheximide; Dizocilpine Maleate; Dose-Response Relationship, Drug; Down-Regulation; Glutamic Acid; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 1995 |
Glutamate receptor-mediated calcium surges in neurons derived from P19 cells.
Topics: Animals; Calcium; Cell Differentiation; Dizocilpine Maleate; Egtazic Acid; Embryonal Carcinoma Stem Cells; Glutamic Acid; Glycine; Kainic Acid; Magnesium; Mice; N-Methylaspartate; Neoplastic Stem Cells; Neurons; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Tretinoin; Tumor Cells, Cultured | 1995 |
Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.
Topics: Alanine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line; Chelating Agents; Cycloleucine; Embryo, Mammalian; Fetus; Glioma; Glutamic Acid; Hippocampus; Humans; Indoles; Kidney; Kinetics; Maleimides; N-Methylaspartate; Neuroblastoma; Neurons; Neurotoxins; PC12 Cells; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Protein Kinase C; Protein Processing, Post-Translational; Pyrimidines; Quinacrine; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1995 |
Excitatory amino acid-induced AP-1 DNA binding activity in Müller glia.
Topics: Animals; Binding, Competitive; Cells, Cultured; Chick Embryo; DNA; Dose-Response Relationship, Drug; Electrophoresis; Excitatory Amino Acids; Glutamic Acid; N-Methylaspartate; Neuroglia; Time Factors; Transcription Factor AP-1 | 1995 |
Protective action of zinc against glutamate neurotoxicity in cultured retinal neurons.
Topics: Animals; Cell Survival; Cells, Cultured; Chlorides; Dose-Response Relationship, Drug; Fetus; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Retina; Zinc Compounds | 1995 |
Prenatal exposure of rats to ammonia impairs NMDA receptor function and affords delayed protection against ammonia toxicity and glutamate neurotoxicity.
Topics: Aging; Ammonia; Animals; Aspartate Aminotransferases; Cells, Cultured; Cerebellum; Diet; Dizocilpine Maleate; Female; Glutamic Acid; L-Lactate Dehydrogenase; Lactation; N-Methylaspartate; Neurons; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1995 |
Interaction between glutamate and luteinizing hormone-releasing hormone (LHRH) in lordosis behavior and luteinizing hormone release (LH): further studies on NMDA receptor mediation.
Topics: Animals; Copulation; Female; Glutamic Acid; Gonadotropin-Releasing Hormone; Luteinizing Hormone; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sexual Behavior, Animal | 1995 |
Phospholipase A2 modulates different subtypes of excitatory amino acid receptors: autoradiographic evidence.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid | 1993 |
35 mM K(+)-stimulated 45Ca2+ uptake in cerebellar granule cell cultures mainly results from NMDA receptor activation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding, Competitive; Calcium; Cell Differentiation; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Magnesium; Mice; N-Methylaspartate; Nifedipine; Phencyclidine; Potassium; Receptors, N-Methyl-D-Aspartate | 1993 |
Binding of [3H]MK-801, NMDA-displaceable [3H]glutamate, [3H]glycine, [3H]spermidine, [3H]kainate and [3H]AMPA to regionally discrete brain membranes of the gerbil: a biochemical study.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain; Cell Membrane; Dizocilpine Maleate; Female; Gerbillinae; Glutamates; Glutamic Acid; Glycine; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Receptors, Glutamate; Spermidine; Thiocyanates; Tissue Distribution | 1993 |
Respiratory responses to microinjection of excitatory amino acid agonists in ventrolateral regions of the lateral parabrachial nucleus in the cat.
Topics: Animals; Axonal Transport; Brain; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Female; Glutamates; Glutamic Acid; Horseradish Peroxidase; Kainic Acid; Male; Microinjections; N-Methylaspartate; Neurons; Quisqualic Acid; Receptors, Glutamate; Respiration; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins | 1993 |
Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Base Sequence; DNA, Neoplasm; Glutamates; Glutamic Acid; Glycine; Humans; Ion Channels; Kinetics; Magnesium; Membrane Potentials; Molecular Sequence Data; N-Methylaspartate; Neurons; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; RNA, Neoplasm; Sequence Homology, Amino Acid; Teratoma; Tumor Cells, Cultured | 1993 |
(R,S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors mediate a calcium-dependent inhibition of the metabotropic glutamate receptor-stimulated formation of inositol 1,4,5-trisphosphate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cycloleucine; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Inositol 1,4,5-Trisphosphate; N-Methylaspartate; Protein Kinases; Rats; Receptors, AMPA; Receptors, Glutamate | 1993 |
Quisqualate resolves two distinct metabotropic [3H]glutamate binding sites.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Corpus Striatum; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid | 1993 |
Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Radioisotopes; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Ibotenic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Quinoxalines; Receptors, Glutamate | 1993 |
beta-Amyloid (25-35) or substance P stimulates [3H]MK-801 binding to rat cortical membranes in the presence of glutamate and glycine.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Biguanides; Cell Membrane; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Molecular Sequence Data; N-Methylaspartate; Peptide Fragments; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Sequence Homology, Amino Acid; Substance P | 1993 |
Glutamate receptor agonists enhance the expression of BDNF mRNA in cultured cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Kinetics; Kynurenic Acid; Molecular Weight; N-Methylaspartate; Nerve Growth Factors; Nerve Tissue Proteins; Quinoxalines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Tetrodotoxin; Transcription, Genetic | 1993 |
Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Cloning, Molecular; Dizocilpine Maleate; DNA; Female; Frontal Lobe; Gene Library; Glutamates; Glutamic Acid; Glycine; Humans; Ibotenic Acid; Kainic Acid; Macromolecular Substances; Molecular Sequence Data; N-Methylaspartate; Oocytes; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sequence Homology, Amino Acid; Transcription, Genetic; Xenopus laevis | 1993 |
Development of dopamine and N-methyl-D-aspartate systems in rat brain: the effect of prenatal phencyclidine exposure.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Animals, Newborn; Corpus Striatum; Dopamine; Female; Frontal Lobe; Glutamates; Glutamic Acid; Hydroxyindoleacetic Acid; Male; Methamphetamine; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 1993 |
Glutamate receptor-induced cyclic GMP formation in primary cultures of mesencephalic neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Arginine; Carbachol; Cells, Cultured; Cyclic GMP; Fetus; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Kinetics; Mesencephalon; Mice; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Phorbol 12,13-Dibutyrate; Quinoxalines; Receptors, Glutamate | 1993 |
Voltage- and transmitter-gated currents of all-amacrine cells in a slice preparation of the rat retina.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cobalt; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; In Vitro Techniques; Ion Channel Gating; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Potassium Channels; Quinoxalines; Rats; Receptors, Amino Acid; Retina; Retinal Ganglion Cells; Sodium Channels; Strychnine; Synapses; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin | 1993 |
Glutamate induces long-term increase in the frequency of single N-methyl-D-aspartate channel openings in hippocampal CA1 neurons examined in situ.
Topics: Animals; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Ion Channels; Membrane Potentials; N-Methylaspartate; Neuronal Plasticity; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses | 1993 |
Mechanisms involved in the neuroprotective activity of a nitric oxide synthase inhibitor during focal cerebral ischemia.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Aspartic Acid; Blood Pressure; Corpus Striatum; Glutamates; Glutamic Acid; Ischemic Attack, Transient; Kinetics; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Potassium; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Lateral hypothalamic injections of glutamate, kainic acid, D,L-alpha-amino-3-hydroxy-5-methyl-isoxazole propionic acid or N-methyl-D-aspartic acid rapidly elicit intense transient eating in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Eating; Glutamates; Glutamic Acid; Hypothalamic Area, Lateral; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Time Factors | 1993 |
AMPA and NMDA binding sites in the hypothalamic lateral tuberal nucleus: implications for Huntington's disease.
Topics: Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Glutamates; Glutamic Acid; Humans; Huntington Disease; Hypothalamic Area, Lateral; Ibotenic Acid; Kainic Acid; Middle Aged; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate | 1993 |
Excitatory amino acid-induced slow biphasic responses of free intracellular calcium in human neuroblastoma cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Calcium; Cycloleucine; Glutamates; Glutamic Acid; Humans; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Receptors, Glutamate; Tumor Cells, Cultured | 1993 |
Aspartate and glutamate mediate excitatory synaptic transmission in area CA1 of the hippocampus.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Calcium; Evoked Potentials; Glucose; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Neurons; Pipecolic Acids; Pyramidal Tracts; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Tritium | 1993 |
Excitatory amino acid receptor mediation of sensory inputs to functionally identified dorsal horn neurons in cat spinal cord.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cats; Decerebrate State; Evoked Potentials; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Ketamine; Kynurenic Acid; N-Methylaspartate; Neurons; Quinoxalines; Quisqualic Acid; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synapses | 1993 |
The topographical basis and frequency-dependence in the effect of different compounds on neurogenic contractions of the guinea-pig ileum.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Cisapride; Electric Stimulation; Electrophysiology; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mollusk Venoms; Muscle Contraction; N-Methylaspartate; Neuropeptide Y; omega-Conotoxin GVIA; Peptides; Piperidines; Potassium; Sodium; Synapses | 1993 |
Effects of L-glutamate, substance P and substance P(1-7) on cardiovascular regulation in the nucleus tractus solitarius.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acid Sequence; Animals; Blood Pressure; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Heart Rate; Male; Medulla Oblongata; Molecular Sequence Data; N-Methylaspartate; Peptide Fragments; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Reference Values; Stereotaxic Techniques; Substance P | 1993 |
Toward an understanding of the role of glutamate in experimental parkinsonism: agonist-sensitive sites in the basal ganglia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basal Ganglia; Cycloleucine; Electromyography; Glutamates; Glutamic Acid; Kainic Acid; Male; Muscles; N-Methylaspartate; Parkinson Disease; Rats; Receptors, Glutamate | 1993 |
Opioid-glutamate interactions in rat locus coeruleus neurons.
Topics: Afferent Pathways; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Glutamates; Glutamic Acid; Locus Coeruleus; Male; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, Opioid, mu; Synaptic Transmission | 1993 |
Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.
Topics: Amino Acid Oxidoreductases; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; Fetus; Glutamates; Glutamic Acid; Immunosuppressive Agents; N-Methylaspartate; Neurons; Neurotoxins; Nitric Oxide Synthase; Phosphorylation; Polyenes; Rats; Rats, Sprague-Dawley; Sirolimus; Tacrolimus | 1993 |
Magnetic resonance spectroscopy studies on Ca2+, Zn2+ and energy metabolism in superfused brain slices.
Topics: Animals; Calcium; Cerebral Cortex; Chelating Agents; Dizocilpine Maleate; Egtazic Acid; Energy Metabolism; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Magnetic Resonance Spectroscopy; N-Methylaspartate; Phosphocreatine; Zinc | 1994 |
Distribution of NMDAR1 receptor subunit mRNA and [125I]MK-801 binding in the hypothalamus of intact, castrate and castrate-DHTP treated male rats.
Topics: Animals; Binding Sites; Dizocilpine Maleate; Glutamic Acid; Hypothalamus; In Situ Hybridization; Iodine Radioisotopes; Male; N-Methylaspartate; Orchiectomy; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Testis | 1995 |
Failure of neuronal ion exchange, not potentiated excitation, causes excitotoxicity after inhibition of oxidative phosphorylation.
Topics: Animals; Dizocilpine Maleate; Glutamic Acid; Ion Exchange; Iontophoresis; Male; N-Methylaspartate; Neurons; Oxidative Phosphorylation; Pyramidal Cells; Rats; Rats, Wistar | 1995 |
Suppression of GABAA receptor responses by NMDA application in hippocampal neurones acutely isolated from the adult guinea-pig.
Topics: Animals; Barium; Calcineurin; Calcium; Calmodulin-Binding Proteins; Egtazic Acid; Electrophysiology; Ethers, Cyclic; GABA-A Receptor Antagonists; Glutamic Acid; Guinea Pigs; Hippocampus; N-Methylaspartate; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation | 1995 |
Glutamate-induced loss of Ca2+/calmodulin-dependent protein kinase II activity in cultured rat hippocampal neurons.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Immunoblotting; Ionomycin; Lipoxygenase Inhibitors; N-Methylaspartate; Neurons; Phosphoprotein Phosphatases; Phosphorylation; Protease Inhibitors; Protein Kinases; Rats; Rats, Wistar | 1995 |
Excitotoxic activation of the NMDA receptor results in inhibition of calcium/calmodulin kinase II activity in cultured hippocampal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Blotting, Western; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Aggregation; Cells, Cultured; Dizocilpine Maleate; Glutamic Acid; Glycine; Hippocampus; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Kinetics; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Neurotoxins; Peptides; Phosphorylation; Potassium Chloride; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate | 1995 |
Glutamate-induced cerebral vasodilation is mediated by nitric oxide through N-methyl-D-aspartate receptors.
Topics: Animals; Animals, Newborn; Cerebrovascular Circulation; Dizocilpine Maleate; Female; Glutamic Acid; Male; N-Methylaspartate; Nitric Oxide; Receptors, N-Methyl-D-Aspartate; Swine; Vasodilation | 1995 |
Inhibitory action of nebracetam on various stimuli-evoked increases in intracellular Ca2+ concentrations in cultured rat cerebellar granule cells.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; Evoked Potentials; Glutamic Acid; N-Methylaspartate; Parasympathomimetics; Potassium Compounds; Pyrrolidinones; Rats; Rats, Wistar | 1995 |
N-methyl-D-aspartate receptors modulate neurotransmitter release and peristalsis in the guinea pig isolated colon.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Colon; Glutamic Acid; Guinea Pigs; Magnesium; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Peristalsis; Receptors, N-Methyl-D-Aspartate | 1995 |
Modulation of the glutamate-evoked release of arachidonic acid from mouse cortical neurons: involvement of a pH-sensitive membrane phospholipase A2.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amiloride; Ammonium Chloride; Animals; Arachidonic Acid; Calcium; Cell Membrane; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Embryo, Mammalian; Female; Glutamic Acid; Harmaline; Hydrogen-Ion Concentration; Immunohistochemistry; Kainic Acid; Kinetics; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Phospholipases A; Phospholipases A2; Pregnancy; Time Factors; Tritium | 1995 |
Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arginine; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Indomethacin; Kainic Acid; Kinetics; Masoprocol; N-Methylaspartate; Neurons; Nitroarginine; Prosencephalon; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence; Time Factors | 1995 |
Glucose regulates glutamate-evoked arachidonic acid release from cultured striatal neurons.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Astrocytes; Calcium; Cells, Cultured; Corpus Striatum; Cytosol; Glucose; Glutamic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Receptors, AMPA; Receptors, Metabotropic Glutamate | 1995 |
Spatial integration of local transmitter responses in motoneurones of the turtle spinal cord in vitro.
Topics: Animals; Dendrites; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Ionophores; Motor Neurons; N-Methylaspartate; Quisqualic Acid; Spinal Cord; Synapses; Synaptic Transmission; Tetraethylammonium; Tetraethylammonium Compounds; Turtles | 1994 |
Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Antimetabolites; Apoptosis; Cells, Cultured; Cerebellum; Culture Media; Dizocilpine Maleate; DNA; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Neurons; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1994 |
Studies on metabolic regulation using NMR spectroscopy.
Topics: Animals; Brain; Calcium; Energy Metabolism; Glucose; Glutamic Acid; Glycerophosphates; Guinea Pigs; Hypoglycemia; Hypoxia, Brain; In Vitro Techniques; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; N-Methylaspartate | 1993 |
Growth conditions differentially modulate the vulnerability of developing cerebellar granule cells to excitatory amino acids.
Topics: Animals; Calcium Radioisotopes; Cells, Cultured; Cerebellum; Excitatory Amino Acids; GABA Agonists; GABA Antagonists; Glutamic Acid; Immunohistochemistry; Kainic Acid; Membrane Potentials; N-Methylaspartate; Potassium; Rats; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tetrazolium Salts; Thiazoles | 1994 |
Dopamine-induced protection of striatal neurons against kainate receptor-mediated glutamate cytotoxicity in vitro.
Topics: Animals; Calcium; Cell Survival; Cells, Cultured; Cytosol; Dopamine; Dopamine Agonists; Dopamine Antagonists; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Neostriatum; Neurons; Patch-Clamp Techniques; Rats; Receptors, Kainic Acid | 1994 |
BW1003C87 and NBQX but not CGS19755 reduce glutamate release and cerebral ischemic necrosis.
Topics: Analysis of Variance; Animals; Binding, Competitive; Brain Ischemia; Disease Models, Animal; Glutamic Acid; Hippocampus; Injections, Intraperitoneal; Injections, Intravenous; Male; Microdialysis; N-Methylaspartate; Necrosis; Neurons; Observer Variation; Pipecolic Acids; Prosencephalon; Pyrimidines; Quinoxalines; Random Allocation; Rats; Rats, Wistar; Receptors, AMPA; Reperfusion Injury | 1994 |
Effects of glutamate, N-methyl-D-aspartate, high potassium, and hypoxia on unit discharges in CA1 area of hippocampal slices of DBA and C57 mice.
Topics: Acoustic Stimulation; Animals; Cell Hypoxia; Glutamic Acid; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; N-Methylaspartate; Neural Conduction; Potassium; Seizures | 1995 |
Ketamine inhibits glutamate-, N-methyl-D-aspartate-, and quisqualate-stimulated cGMP production in cultured cerebral neurons.
Topics: Animals; Brain; Cells, Cultured; Cyclic GMP; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Ketamine; N-Methylaspartate; Neurons; Nitric Oxide; Nitroprusside; Quisqualic Acid; Rats; Rats, Sprague-Dawley | 1995 |
Interleukin-1 modulates GABAergic and glutamatergic function in brain.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain; Calcium; Cells, Cultured; Chick Embryo; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Interleukin-1; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Recombinant Proteins; Spermine; Tumor Necrosis Factor-alpha | 1994 |
Photoperiodically induced changes in glutamatergic stimulation of LH secretion in male Syrian hamsters: role of circulating testosterone and endogenous opioids.
Topics: Animals; Cricetinae; Drug Implants; Feedback; Glutamic Acid; Luteinizing Hormone; Male; Mesocricetus; N-Methylaspartate; Naloxone; Opioid Peptides; Orchiectomy; Photoperiod; Testis; Testosterone | 1994 |
GABAA and NMDA receptor activation controls somatostatin messenger RNA expression in primary cultures of hypothalamic neurons.
Topics: Animals; Bicuculline; Cells, Cultured; Dizocilpine Maleate; Gene Expression; Glutamic Acid; Hypothalamus; Muscimol; N-Methylaspartate; Neurons; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Somatostatin | 1994 |
Plasticity of NMDA receptor expression during mouse cerebellar granule cell development.
Topics: Animals; Cells, Cultured; Cerebellum; Glutamic Acid; Mice; N-Methylaspartate; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate | 1994 |
Altered modulation by excitatory amino acids of cortical phosphatidylinositol system stimulated by carbachol in rats poisoned by an anti-cholinesterase compound, diisopropyl fluorophosphate.
Topics: Animals; Carbachol; Cerebral Cortex; Glutamic Acid; In Vitro Techniques; Isoflurophate; Male; N-Methylaspartate; Phosphatidylinositols; Rats; Rats, Sprague-Dawley | 1994 |
Accumulation of 3H-phosphoinositides mediated by muscarinic receptors in the developing chick retina: inhibition of carbachol-induced response by glutamate receptors.
Topics: Animals; Atropine; Carbachol; Chick Embryo; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Phosphatidylinositols; Physostigmine; Pirenzepine; Receptors, Glutamate; Receptors, Muscarinic; Retina | 1995 |
Glutamate-induced intracellular calcium changes and neurotoxicity in cortical neurons in vitro: effect of chemical ischemia.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cell Hypoxia; Cells, Cultured; Dizocilpine Maleate; Glutamic Acid; Glycine; Kainic Acid; N-Methylaspartate; Neurons; Nimodipine; Potassium Chloride; Potassium Cyanide; Prosencephalon; Rats; Rats, Sprague-Dawley | 1994 |
HIV-1 envelope protein gp120 potentiates NMDA-evoked noradrenaline release by a direct action at rat hippocampal and cortical noradrenergic nerve endings.
Topics: Animals; Cerebral Cortex; Drug Synergism; Glutamic Acid; Hippocampus; HIV Envelope Protein gp120; In Vitro Techniques; Male; N-Methylaspartate; Nerve Endings; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1994 |
Synergistic effects of acetylcholine and glutamate on the release of arachidonic acid from cultured striatal neurons.
Topics: Acetylcholine; Animals; Arachidonic Acid; Calcium; Carbachol; Cells, Cultured; Corpus Striatum; Drug Synergism; Glutamic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Protein Kinase C | 1995 |
Carbachol-induced accumulation of inositol phosphates and its modulation by excitatory amino acids in cortical slices of young and aged rats with down-regulation of muscarinic M-1 receptors.
Topics: Aging; Analysis of Variance; Animals; Carbachol; Cerebral Cortex; Down-Regulation; Excitatory Amino Acids; Glutamic Acid; In Vitro Techniques; Inositol Phosphates; Isoflurophate; Male; N-Methylaspartate; Rats; Rats, Inbred F344; Receptors, Muscarinic; Syndrome | 1994 |
Chronic mild acidosis specifically reduces functional expression of N-methyl-D-aspartate receptors and increases long-term survival in primary cultures of cerebellar granule cells.
Topics: Acidosis; Animals; Cell Survival; Cells, Cultured; Cerebellum; Chronic Disease; Electrophysiology; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 1994 |
Regulation of dopamine levels in intrastriatal grafts of fetal mesencephalic cell suspension: an in vivo voltammetric approach.
Topics: 2-Amino-5-phosphonovalerate; 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Benzazepines; Brain Tissue Transplantation; Cerebral Ventricles; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine D2 Receptor Antagonists; Female; Fetal Tissue Transplantation; Glutamic Acid; Injections, Intraventricular; Kinetics; Mesencephalon; N-Methylaspartate; Oxidopamine; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Dopamine D1; Sulpiride; Time Factors; Transplantation, Heterotopic | 1994 |
Melatonin protects primary cultures of cerebellar granule neurons from kainate but not from N-methyl-D-aspartate excitotoxicity.
Topics: Animals; Cerebellum; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Melatonin; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats | 1995 |
An aggregate brain cell culture model for studying neuronal degeneration and regeneration.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Acetylcholinesterase; Animals; Biomarkers; Cell Aggregation; Choline O-Acetyltransferase; Dizocilpine Maleate; DNA; Fetus; Gestational Age; Glutamate-Ammonia Ligase; Glutamic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Degeneration; Nerve Regeneration; Neuroglia; Neurons; Rats; Reproducibility of Results; Telencephalon | 1994 |
Differential L-glutamate responsiveness among superficial dorsal horn neurons.
Topics: Animals; Cricetinae; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Mesocricetus; Microelectrodes; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1994 |
Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons.
Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; N-Methylaspartate; Neurons; Neurotransmitter Agents; Nitroprusside; Pregnancy; Rats; S-Adenosylmethionine; Vitamin B 12 | 1993 |
N-methyl-D-aspartic acid/glycine interactions on the control of 5-hydroxytryptamine release in raphe primary cultures.
Topics: Animals; Cells, Cultured; Embryo, Mammalian; Female; Gestational Age; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; N-Methylaspartate; Pregnancy; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Rhombencephalon; Serotonin; Strychnine; Valine | 1993 |
Further evidence for multiple forms of an N-methyl-D-aspartate recognition domain in rat brain using membrane binding techniques.
Topics: 2-Amino-5-phosphonovalerate; 4-Chloromercuribenzenesulfonate; Animals; Brain; Dithionitrobenzoic Acid; Dizocilpine Maleate; Ethylmaleimide; Glutamates; Glutamic Acid; Kinetics; Male; N-Methylaspartate; Piperazines; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Sulfhydryl Reagents; Synaptic Membranes | 1993 |
Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in hippocampal neurons.
Topics: Animals; Base Sequence; Blotting, Western; Calcium; Cell Survival; Cells, Cultured; Embryo, Mammalian; Fibroblast Growth Factor 2; Gene Expression; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Kinetics; Molecular Sequence Data; N-Methylaspartate; Neurons; Neurotoxins; Oligodeoxyribonucleotides; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1993 |
Preservation of hippocampal NMDA receptors may be crucial for spatial learning after epileptic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cognition Disorders; Electric Stimulation; Epilepsy; Glutamates; Glutamic Acid; Hippocampus; Learning; Male; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Somatostatin; Space Perception | 1993 |
Neurochemical and electrophysiological studies on FR115427, a novel non-competitive NMDA receptor antagonist.
Topics: Action Potentials; Animals; Binding, Competitive; Cerebral Cortex; Dizocilpine Maleate; Electrophysiology; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Isoquinolines; Male; N-Methylaspartate; Neurons; Pyramidal Cells; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Synaptic Transmission; Tetrahydroisoquinolines | 1993 |
Excitatory amino acid-induced phosphoinositide hydrolysis in Müller glia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Chickens; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hydrolysis; Inositol Phosphates; Kainic Acid; N-Methylaspartate; Neuroglia; Quinoxalines; Quisqualic Acid; Receptors, Amino Acid; Retina; Tritium | 1993 |
Mechanisms underlying developmental changes in the expression of metabotropic glutamate receptors in cultured cerebellar granule cells: homologous desensitization and interactive effects involving N-methyl-D-aspartate receptors.
Topics: Aging; Animals; Carbachol; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Hydrolysis; N-Methylaspartate; Phosphatidylinositol Phosphates; Potassium; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1993 |
Synaptic excitation triggers oscillations during NMDA receptor activation in rat abducens motoneurons.
Topics: 2-Amino-5-phosphonovalerate; Abducens Nerve; Animals; Dizocilpine Maleate; Electrophysiology; Evoked Potentials; Glutamates; Glutamic Acid; Ketamine; Male; Motor Neurons; N-Methylaspartate; Oscillometry; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses | 1993 |
Cyclic guanosine monophosphate mediates penile erection in the rat.
Topics: Alprostadil; Animals; Calcitonin Gene-Related Peptide; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Ethylmaleimide; Glutamates; Glutamic Acid; Male; Methylene Blue; Muscle Relaxation; N-Methylaspartate; Neurotransmitter Agents; Nitroprusside; Papaverine; Penile Erection; Rats; Rats, Sprague-Dawley; Vasoactive Intestinal Peptide | 1993 |
Differential responses in cyclic GMP formation induced by excitatory amino acids (EAA) and sodium nitroprusside (SNP) in various regions of the brain and of rats of varied age.
Topics: Aging; Amino Acids; Animals; Brain; Cyclic GMP; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Nitroprusside; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sex Characteristics | 1993 |
Endogenous nitric oxide inhibits NMDA- and kainate- responses by a negative feedback system in rat hippocampal neurons.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Arginine; Calcium; Cells, Cultured; Cyclic GMP; Feedback; Glutamates; Glutamic Acid; Hemoglobins; Hippocampus; Kainic Acid; N-Methylaspartate; Neurons; Nitric Oxide; Nitroarginine; Osmolar Concentration; Rats; Rats, Wistar; Receptors, Amino Acid | 1993 |
Glutamate receptors in the rat hypothalamus and pituitary.
Topics: Animals; Autoradiography; Binding, Competitive; Glutamates; Glutamic Acid; Hypothalamus; Kinetics; Male; N-Methylaspartate; Organ Specificity; Pituitary Gland; Rats; Receptors, Glutamate; Tritium | 1994 |
Activation of NMDA receptors increases brain-derived neurotrophic factor (BDNF) mRNA expression in the hippocampal formation.
Topics: Animals; Brain-Derived Neurotrophic Factor; Female; Gene Expression Regulation; Glutamates; Glutamic Acid; Hippocampus; In Situ Hybridization, Fluorescence; Injections, Intraventricular; N-Methylaspartate; Nerve Tissue Proteins; Neuronal Plasticity; Pyramidal Cells; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Stimulation, Chemical | 1993 |
Comparison of double fluorescence staining and LDH-test for monitoring cell viability in vitro.
Topics: Animals; Biomarkers; Cell Survival; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Cytological Techniques; Fluoresceins; Fluorescent Dyes; Glutamates; Glutamic Acid; Hydrolysis; Kainic Acid; L-Lactate Dehydrogenase; Microscopy, Fluorescence; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neuroglia; Neurons; Neurotoxins; Propidium; Quinolinic Acid; Rats; Rats, Wistar | 1993 |
Protective action of dopamine against glutamate neurotoxicity in the retina.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Cell Death; Cells, Cultured; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Antagonists; Fetus; Fluorescent Antibody Technique; Glutamates; Glutamic Acid; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Retina | 1994 |
NMDA-receptor channel diversity in the developing cerebellum.
Topics: Animals; Cell Movement; Cerebellum; Glutamates; Glutamic Acid; In Vitro Techniques; Ion Channel Gating; Membrane Potentials; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Requirement for BDNF in activity-dependent survival of cortical neurons.
Topics: Animals; Antibodies; Brain-Derived Neurotrophic Factor; Calcium Channels; Cell Division; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Embryo, Mammalian; Glutamates; Glutamic Acid; N-Methylaspartate; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Phosphorylation; Potassium Chloride; Rats; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 1994 |
Are the disparate pharmacological profiles of competitive and un-competitive NMDA antagonists due to different baseline activities of distinct glutamatergic pathways? (Hypothesis).
Topics: Animals; Binding, Competitive; Cerebral Cortex; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Globus Pallidus; Glutamates; Glutamic Acid; Humans; Models, Biological; Motor Activity; N-Methylaspartate; Neural Pathways; Receptors, N-Methyl-D-Aspartate; Thalamus | 1993 |
Neuroprotective activity of acetyl-L-carnitine: studies in vitro.
Topics: Acetylcarnitine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood Physiological Phenomena; Cattle; Cell Death; Cells, Cultured; Cerebral Cortex; Culture Media; Energy Metabolism; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Hippocampus; Humans; Kainic Acid; N-Methylaspartate; Neurons; Peptide Fragments; Rats | 1994 |
Heterocarrier-mediated reciprocal modulation of glutamate and glycine release in rat cerebral cortex and spinal cord synaptosomes.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium; Spinal Cord; Synaptosomes | 1994 |
(1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid attenuates N-methyl-D-aspartate-induced neuronal cell death in cortical cultures via a reduction in delayed Ca2+ accumulation.
Topics: Animals; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Cycloleucine; Fetus; Glutamates; Glutamic Acid; Kinetics; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neurotoxins; Pertussis Toxin; Phosphatidylinositols; Rats; Time Factors; Virulence Factors, Bordetella | 1993 |
An ibotenate-selective metabotropic glutamate receptor mediates protein phosphorylation in cultured hippocampal pyramidal neurons.
Topics: Animals; Calcium; Cycloleucine; Diglycerides; Embryo, Mammalian; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Inositol; Inositol Phosphates; Kainic Acid; Myristic Acid; Myristic Acids; N-Methylaspartate; Nerve Tissue Proteins; Neurotoxins; Pertussis Toxin; Phosphatidylcholines; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Protein Kinase C; Pyramidal Cells; Quisqualic Acid; Rats; Receptors, Glutamate; Stearic Acids; Virulence Factors, Bordetella | 1994 |
Cobalt blocks L-glutamate-induced apnea and arterial hypotension in the nucleus tractus solitarii of anaesthetized rats.
Topics: Anesthesia; Animals; Apnea; Blood Pressure; Cobalt; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Male; Microinjections; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Solitary Nucleus | 1994 |
Glutamate as a neuron-to-glial signal for mitogenesis: role of glial N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; Aged; Aged, 80 and over; Cell Division; Cells, Cultured; Dizocilpine Maleate; DNA; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Humans; Middle Aged; N-Methylaspartate; Neuroglia; Neurons; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Retina; Signal Transduction | 1993 |
Activation of glutamate receptors stimulates the formation of nitrite in synaptosomes from rat cerebellum.
Topics: Animals; Cerebellum; Cycloleucine; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Nitrites; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synaptosomes | 1994 |
Excitotoxic amino acids cause appearance of magnetic resonance spectroscopy-observable zinc in superfused cortical slices.
Topics: Animals; Calcium; Cerebral Cortex; Glutamates; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Intracellular Membranes; Magnesium; Magnetic Resonance Imaging; N-Methylaspartate; Zinc | 1994 |
Nerve injury increases the susceptibility of motoneurons to N-methyl-D-aspartate-induced neurotoxicity in the developing rat.
Topics: Animals; Animals, Newborn; Axons; Cell Survival; Glutamates; Glutamic Acid; Histocytochemistry; Horseradish Peroxidase; Motor Neurons; N-Methylaspartate; Nerve Crush; Rats; Rats, Wistar; Sciatic Nerve | 1994 |
Release of 3H-noradrenaline by excitatory amino acids from rat mediobasal hypothalamus and the influence of aging.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Amino Acids; Animals; Glutamates; Glutamic Acid; Hypothalamus, Middle; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Rats; Tritium | 1994 |
Presence of N-methyl-D-aspartate (NMDA) receptors in neuroblastoma x glioma hybrid NG108-15 cells-analysis using [45Ca2+]influx and [3H]MK-801 binding as functional measures.
Topics: Calcium Radioisotopes; Cations, Divalent; Dizocilpine Maleate; Glioma; Glutamates; Glutamic Acid; Glycine; Hybrid Cells; N-Methylaspartate; Neuroblastoma; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Spermine; Tritium | 1994 |
Activation of brain acetylcholine receptors by neuromuscular blocking drugs. A possible mechanism of neurotoxicity.
Topics: Acetylcholine; Anesthesia, General; Animals; Atracurium; Brain; Calcium; Convulsants; Dose-Response Relationship, Drug; Enflurane; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Isoquinolines; Kainic Acid; Male; N-Methylaspartate; Neuromuscular Nondepolarizing Agents; Neurotoxins; Nicotine; Pancuronium; Phenytoin; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Time Factors; Tubocurarine; Vecuronium Bromide | 1994 |
Greater sensitivity of larger retinal ganglion cells to NMDA-mediated cell death.
Topics: Animals; Cell Death; Cell Size; Drug Resistance; Glutamates; Glutamic Acid; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells | 1994 |
Dopamine D1 and D2 receptor antagonism differentially modulates stimulation of striatal neurotransmitter levels by N-methyl-D-aspartic acid.
Topics: Animals; Benzazepines; Dopamine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Microdialysis; N-Methylaspartate; Neostriatum; Neurotransmitter Agents; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Salicylamides | 1994 |
Changes in cytosolic sodium caused by a toxic glutamate treatment of cultured hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cells, Cultured; Culture Techniques; Cytosol; Glutamates; Glutamic Acid; Hippocampus; Kinetics; Magnesium; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Wistar; Sodium; Time Factors; Veratridine | 1994 |
The effect of L-glutamate on the afferent resting activity in the cephalopod statocyst.
Topics: Action Potentials; Afferent Pathways; Animals; Aspartic Acid; Decapodiformes; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Kainic Acid; Male; Mollusca; N-Methylaspartate; Nerve Fibers; Octopodiformes; Postural Balance; Quisqualic Acid; Species Specificity | 1994 |
Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell death.
Topics: Animals; Cell Death; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Glutamates; Glutamic Acid; Hippocampus; Interleukin-6; N-Methylaspartate; Neurons; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
Glutamate uptake blockade induces striatal dopamine release in 6-hydroxydopamine rats with intrastriatal grafts: evidence for host modulation of transplanted dopamine neurons.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Diseases; Brain Tissue Transplantation; Corpus Striatum; Dopamine; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kainic Acid; Male; Mesencephalon; N-Methylaspartate; Neurons; Oxidopamine; Rats; Tyrosine 3-Monooxygenase | 1994 |
Release of chicken luteinising hormone-releasing hormone-I (cLHRH-I) by mediobasal hypothalamus in the cockerel: validation of an incubation system and effect of excitatory amino acids.
Topics: Amino Acids; Animals; Chickens; Glutamates; Glutamic Acid; Gonadotropin-Releasing Hormone; Hypothalamus, Middle; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Pyrrolidonecarboxylic Acid; Radioimmunoassay | 1994 |
Comparison of the potency of competitive NMDA antagonists against the neurotoxicity of glutamate and NMDA.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Binding, Competitive; Cell Survival; Cells, Cultured; Cerebral Cortex; Dendrites; Dizocilpine Maleate; Embryo, Mammalian; Glutamates; Glutamic Acid; N-Methylaspartate; Neurons; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Delayed application of aurintricarboxylic acid reduces glutamate-induced cortical neuronal injury.
Topics: Animals; Apoptosis; Aurintricarboxylic Acid; Blotting, Southern; Calcium; Cells, Cultured; Cerebral Cortex; Cytosol; DNA; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Mice; N-Methylaspartate; Neurons; Potassium; Receptors, N-Methyl-D-Aspartate | 1994 |
Homolateral cerebrocortical increase of immediate early gene and neurotransmitter messenger RNAs after minimal cortical lesion: blockade by N-methyl-D-aspartate antagonist.
Topics: Animals; Cerebral Cortex; Cerebral Infarction; Cholecystokinin; Dizocilpine Maleate; DNA-Binding Proteins; Early Growth Response Protein 1; Female; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Genes, jun; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Immediate-Early Proteins; Leucine Zippers; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neuropeptide Y; Neurotransmitter Agents; Nuclear Receptor Subfamily 4, Group A, Member 1; Parietal Lobe; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Somatostatin; Time Factors; Transcription Factors; Zinc Fingers | 1994 |
Properties of GABA and glutamate responses in identified glial cells of the mouse hippocampal slice.
Topics: Animals; Barium; Electrodes; Electrophysiology; Glial Fibrillary Acidic Protein; Glutamates; Glutamic Acid; Hippocampus; Immunohistochemistry; In Vitro Techniques; Kainic Acid; Mice; N-Methylaspartate; Neuroglia; Potassium Channels; Receptors, GABA-A; Receptors, Glutamate | 1994 |
Glutamate agonists and [3H]GABA release from rat hippocampal slices: involvement of metabotropic glutamate receptors in the quisqualate-evoked release.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Kinetics; Male; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1994 |
Changes in oxygenation states of rat brain tissues during glutamate-related epileptic seizures--near-infrared study.
Topics: Animals; Brain; Dizocilpine Maleate; Electroencephalography; Electron Transport Complex IV; Epilepsy; Glutamates; Glutamic Acid; Hemoglobins; Kainic Acid; Male; N-Methylaspartate; Oxidation-Reduction; Oxygen; Rats; Rats, Wistar; Spectrophotometry, Infrared | 1994 |
Release of adenosine by activation of NMDA receptors in the hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; Animals; Electric Stimulation; Enkephalins; GABA-B Receptor Antagonists; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Interneurons; Male; N-Methylaspartate; Neural Inhibition; Organophosphorus Compounds; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Theophylline | 1994 |
Excitatory amino acid receptors in glial progenitor cells: molecular and functional properties.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Cerebral Cortex; DNA-Binding Proteins; Early Growth Response Protein 1; Gene Expression Regulation; Genes, Immediate-Early; Glutamic Acid; Immediate-Early Proteins; Kainic Acid; Membrane Potentials; N-Methylaspartate; Nerve Tissue Proteins; Neurotoxins; Oligodendroglia; Rats; Receptors, Glutamate; Stem Cells; Transcription Factors | 1994 |
Density of NMDA-coupled and uncoupled 1-[1-(2-[3H]thienyl) cyclohexyl]piperidine recognition sites in the brain and spinal cord: differential effects of NMDA agonists and antagonists.
Topics: Animals; Binding Sites; Brain; Brain Chemistry; Dizocilpine Maleate; Glutamic Acid; Glycine; Haloperidol; Male; Mice; N-Methylaspartate; Phencyclidine; Spinal Cord; Tritium | 1994 |
Kainic acid stimulates uptake of divalent cations in postnatal cochlear neurons.
Topics: Animals; Cations, Divalent; Cobalt; Cochlea; Cricetinae; Dose-Response Relationship, Drug; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Organ Culture Techniques; Quinoxalines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate | 1994 |
A subtype of the metabotropic glutamate receptor family in the olfactory system of Atlantic salmon.
Topics: Animals; Aspartic Acid; Blotting, Northern; Brain; Cell Membrane; DNA Probes; Glutamic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kainic Acid; N-Methylaspartate; Nucleic Acid Hybridization; Olfactory Mucosa; Rats; Receptors, Metabotropic Glutamate; Salmon; Taurocholic Acid; Type C Phospholipases | 1994 |
L-glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L-glutamate without direct activation of mGluR1a.
Topics: Alanine Transaminase; Animals; Asparagine; Aspartic Acid; Cell Line; Cell Membrane; Cricetinae; Cycloleucine; Cysteine; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Glutamate Decarboxylase; Glutamic Acid; Hydrolysis; Kidney; N-Methylaspartate; Phosphatidylinositols; Pyrrolidines; Receptors, Metabotropic Glutamate | 1994 |
Selective increase of NMDA-sensitive glutamate binding in the striatum of Parkinson's disease, Alzheimer's disease, and mixed Parkinson's disease/Alzheimer's disease patients: an autoradiographic study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acids; Autoradiography; Binding Sites; Carrier Proteins; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Female; Glutamic Acid; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; N-Methylaspartate; Nerve Tissue Proteins; Parkinson Disease; Receptors, Amino Acid; Receptors, AMPA; Receptors, Glutamate | 1994 |
Effect of excitatory amino acid receptor agonists on secretion of growth hormone as assessed by the reverse hemolytic plaque assay.
Topics: Amino Acids; Animals; Glutamic Acid; Growth Hormone; Growth Hormone-Releasing Hormone; Hemolytic Plaque Technique; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Somatostatin | 1994 |
Cortical neurons containing calretinin are selectively resistant to calcium overload and excitotoxicity in vitro.
Topics: Animals; Buffers; Calbindin 2; Calcimycin; Calcium; Cell Death; Cells, Cultured; Drug Resistance; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Neurotoxins; Rats; S100 Calcium Binding Protein G; Visual Cortex | 1994 |
N-methyl-D-aspartate receptor-mediated voltage oscillations in neurons surrounding the central canal in slices of rat spinal cord.
Topics: Animals; Culture Techniques; Glutamic Acid; Locomotion; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission | 1994 |
Partial purification of [3H]glutamate-associating-proteins with sensitivity to displacement by N-methyl-D-aspartate from rat brain.
Topics: Animals; Binding, Competitive; Brain; Chromatography; Chromatography, Gel; Chromatography, High Pressure Liquid; Edetic Acid; Glutamic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Potassium Chloride; Rats; Rats, Wistar; Receptors, Glutamate; Solubility; Synaptic Membranes; Tritium | 1994 |
Presynaptic control of dopamine synthesis and release by excitatory amino acids in rat striatal synaptosomes.
Topics: Animals; Binding, Competitive; Corpus Striatum; Dopamine; Excitatory Amino Acid Agonists; Glutamic Acid; Magnesium; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptosomes; Tritium; Tyrosine; Water | 1994 |
Involvement of NMDA receptors in naloxone-induced contractions of the isolated guinea pig ileum after preincubation with morphine.
Topics: Animals; Electric Stimulation; Glutamic Acid; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; N-Methylaspartate; Naloxone; Receptors, N-Methyl-D-Aspartate | 1994 |
N-methyl-D-aspartate releases gamma-aminobutyric acid from rat striatum in vivo: a microdialysis study using a novel preloading method.
Topics: Animals; Aspartic Acid; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Infusions, Parenteral; Kinetics; Male; N-Methylaspartate; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors; Tritium | 1993 |
Development of glutamate and NMDA sensitivity of neurons within the cochlear nuclear complex of kittens.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Acoustic Stimulation; Age Factors; Animals; Brain Mapping; Cats; Cochlear Nerve; Dose-Response Relationship, Drug; Evoked Potentials, Auditory; Glutamates; Glutamic Acid; N-Methylaspartate; Neurons; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1993 |
Opioid receptor-mediated inhibition of evoked catecholamine release from cultured neurons of rat ventral mesencephalon and locus coeruleus.
Topics: Animals; Catecholamines; Cells, Cultured; Dopamine; Glutamates; Glutamic Acid; Locus Coeruleus; Mesencephalon; N-Methylaspartate; Neurons; Norepinephrine; Rats; Receptors, Opioid; Tritium | 1993 |
The effects of neurotransmitters on the integrative properties of spinal neurons in the lamprey.
Topics: Amino Acids; Animals; Data Interpretation, Statistical; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Lampreys; Membrane Potentials; Models, Neurological; N-Methylaspartate; Neurons; Neurotransmitter Agents; Quisqualic Acid; Spinal Cord; Synapses | 1993 |
The effects of intrathecal administration of excitatory amino acid agonists and antagonists on the initiation of locomotion in the adult cat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Cats; Decerebrate State; Electromyography; Glutamates; Glutamic Acid; Hindlimb; Injections, Spinal; Kainic Acid; Laminectomy; Locomotion; Motor Activity; Muscles; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Spinal Cord; Time Factors | 1993 |
Glutamate neurotoxicity: a role for non-N-methyl-D-aspartate receptors?
Topics: Animals; Brain; Cells, Cultured; Choline O-Acetyltransferase; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Somatostatin | 1993 |
Optical imaging of parallel fiber activation in the rat cerebellar cortex: spatial effects of excitatory amino acids.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cerebellar Cortex; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Nerve Fibers; Quisqualic Acid; Rats; Rats, Sprague-Dawley | 1993 |
NMDA-sensitive [3H]glutamate binding in the epileptic rat hippocampus: an autoradiographic study.
Topics: Animals; Autoradiography; Cell Death; Electroencephalography; Epilepsy; Glutamates; Glutamic Acid; Hippocampus; Histocytochemistry; Kinetics; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1993 |
NMDA-like receptors in the CNS of molluscs.
Topics: Animals; Ganglia; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Lymnaea; Magnesium; Membrane Potentials; N-Methylaspartate; Nervous System Physiological Phenomena; Neurons; Receptors, N-Methyl-D-Aspartate | 1993 |
Modulation of neuronal migration by NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 4-Chloromercuribenzenesulfonate; Animals; Calcium; Cell Movement; Cerebellum; Dizocilpine Maleate; Egtazic Acid; Glutamates; Glutamic Acid; Glycine; Magnesium; Mice; N-Methylaspartate; Neurons; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 1993 |
An experimental arthritis model in rats: the effects of NMDA and non-NMDA antagonists on aspartate and glutamate release in the dorsal horn.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Arthritis; Aspartic Acid; Carrageenan; Glutamates; Glutamic Acid; Injections, Intra-Articular; Kaolin; Knee Joint; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Spinal Cord | 1993 |
Glutamate and theta-rhythm stimulation selectively enhance NMDA component of EPSC in CA1 neurons of young rats.
Topics: Aging; Animals; Arginine; Evoked Potentials; Glutamates; Glutamic Acid; Hemoglobins; In Vitro Techniques; N-Methylaspartate; Neuronal Plasticity; Neurons; Nitroarginine; Norepinephrine; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Theta Rhythm | 1993 |
N-methyl-D-aspartic acid differentially regulates extracellular dopamine, GABA, and glutamate levels in the dorsolateral neostriatum of the halothane-anesthetized rat: an in vivo microdialysis study.
Topics: Anesthesia; Animals; Corpus Striatum; Dialysis; Dopamine; Extracellular Space; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Halothane; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley | 1993 |
Effects of excitatory amino acids on inositol phosphate accumulation in slices of the cerebral cortex of young and aged rats.
Topics: Aging; Amino Acids; Animals; Carbachol; Cerebral Cortex; Glutamates; Glutamic Acid; Inositol Phosphates; Male; N-Methylaspartate; Norepinephrine; Quisqualic Acid; Rats; Rats, Sprague-Dawley | 1993 |
Pharmacological characterization of metabotropic glutamate receptors in cultured cerebellar granule cells.
Topics: Alanine; Amino Acids, Diamino; Animals; Cells, Cultured; Cerebellum; Cyanobacteria Toxins; Cycloleucine; Drug Interactions; Enzyme Activation; Glutamates; Glutamic Acid; Ibotenic Acid; Magnesium; N-Methylaspartate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Quisqualic Acid; Rats; Receptors, Glutamate | 1993 |
The triggering of spreading depression in the chicken retina: a pharmacological study.
Topics: Adenosine; Amino Acids; Animals; Baclofen; Calcium Channel Blockers; Chickens; Depression, Chemical; Excitatory Amino Acid Antagonists; Eye Enucleation; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Potassium; Quisqualic Acid; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Retina | 1993 |
Distribution of NMDA receptor binding in developing mouse spinal cord.
Topics: Animals; Animals, Newborn; Autoradiography; Glutamates; Glutamic Acid; Ligands; Mice; Mice, Inbred BALB C; N-Methylaspartate; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Substantia Gelatinosa | 1993 |
Induction of a neuroprotective state in cerebellar granule cells following activation of N-methyl-D-aspartate receptors.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebellum; Cycloheximide; Dactinomycin; Dizocilpine Maleate; Glutamates; Glutamic Acid; N-Methylaspartate; Neurons; Neurotoxins; Pyridinium Compounds; Receptors, N-Methyl-D-Aspartate | 1993 |
NMDA evokes an L-NAME sensitive spinal release of glutamate and citrulline.
Topics: Animals; Arginine; Citrulline; Dialysis; Dizocilpine Maleate; Glutamates; Glutamic Acid; Injections, Spinal; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Spinal Cord | 1993 |
Ethanol prevents the glutamate release induced by N-methyl-D-aspartate in the rat striatum.
Topics: Animals; Corpus Striatum; Dizocilpine Maleate; Ethanol; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Effect of KB-2796, a new diphenylpiperazine Ca2+ antagonist, on glutamate-induced neurotoxicity in rat hippocampal primary cell cultures.
Topics: Animals; Calcium Channel Agonists; Calcium Channel Blockers; Cell Survival; Cells, Cultured; Chelating Agents; Female; Glutamates; Glutamic Acid; Hippocampus; N-Methylaspartate; Nervous System Diseases; Piperazines; Pregnancy; Rats; Rats, Wistar | 1993 |
Lateral tegmental field involvement in the central sympathoinhibitory action of 8-OH-DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Pressure; Cats; Clonidine; Denervation; Electric Stimulation; Glutamates; Glutamic Acid; Kainic Acid; Microinjections; N-Methylaspartate; Neurons; Pressoreceptors; Sympatholytics; Tegmentum Mesencephali | 1993 |
Glutamate neurons in hypothalamus regulate excitatory transmission.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cells, Cultured; Evoked Potentials; Glutamates; Glutamic Acid; Hypothalamus; Microscopy, Electron; N-Methylaspartate; Neurites; Neurons; Quinoxalines; Rats; Receptors, Glutamate; Synapses; Synaptic Transmission | 1993 |
Long-term GABA treatment elicits supersensitivity of quisqualate-preferring metabotropic glutamate receptor in cultured rat cerebellar neurons.
Topics: Animals; Baclofen; Carbachol; Cells, Cultured; Cerebellum; Drug Tolerance; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Potassium Chloride; Pyridazines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glutamate | 1993 |
Intracellular calcium dynamics and cerebral injury: modeling various insults in vitro.
Topics: Brain Injuries; Calcium; Cells, Cultured; Energy Metabolism; Glutamates; Glutamic Acid; Models, Neurological; N-Methylaspartate; Spinal Cord | 1993 |
Age-related effects of NMDA-stimulated concomitant release of nitric oxide and glutamate in cortical slices prepared from DBA/2 mice.
Topics: Acoustic Stimulation; Aging; Animals; Cerebral Cortex; Disease Susceptibility; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Nitric Oxide; Seizures | 1993 |
High-affinity kainate binding sites in living slices of rat neocortex: characterization and regulation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Age Factors; Animals; Binding, Competitive; Cerebral Cortex; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Male; N-Methylaspartate; Nerve Tissue Proteins; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Kainic Acid; Veratridine | 1993 |
A functional in vitro model for studying the cellular and molecular basis of spinal cord injury.
Topics: Animals; Animals, Newborn; Brain Stem; Cell Death; Glutamates; Glutamic Acid; Hindlimb; Locomotion; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Cord Injuries | 1993 |
N-methyl-D-aspartate receptor agonists decrease protooncogene bcl-2 mRNA expression in cultured rat cerebellar granule neurons.
Topics: Actins; Animals; Aurintricarboxylic Acid; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Kinetics; N-Methylaspartate; Neurons; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogenes; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Time Factors | 1993 |
Glutamate-induced increases in intracellular free Mg2+ in cultured cortical neurons.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Fluorescent Dyes; Fura-2; Glutamates; Glutamic Acid; Glycine; Kainic Acid; Kinetics; Magnesium; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Veratridine | 1993 |
Evidence for enhanced synaptic excitation in transplanted neostriatal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Electrophysiology; Fetal Tissue Transplantation; Glutamates; Glutamic Acid; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Synapses; Synaptic Transmission | 1993 |
Postischemic changes in the binding of excitatory and inhibitory neurotransmitters in the gerbil brain.
Topics: Animals; Autoradiography; Brain Chemistry; Dizocilpine Maleate; gamma-Aminobutyric Acid; Gerbillinae; Glutamates; Glutamic Acid; Histocytochemistry; Ischemic Attack, Transient; Male; Muscimol; N-Methylaspartate; Neurotransmitter Agents; Receptors, GABA; Receptors, N-Methyl-D-Aspartate | 1993 |
Characterization of a presynaptic glutamate receptor.
Topics: Animals; Antigens, Surface; Brain; Brain Chemistry; Calcium; Cells, Cultured; Cloning, Molecular; Glutamates; Glutamic Acid; Humans; Membrane Potentials; Mutagenesis, Site-Directed; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Oocytes; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic; Syntaxin 1; Xenopus | 1993 |
Paroxysmal long-lasting depolarizations in cultured hippocampal neurons are generated by activation of NMDA and non-NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Cells, Cultured; Electric Stimulation; Embryo, Mammalian; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Magnesium; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Tetrodotoxin | 1993 |
NMDA-stimulated expression of BDNF mRNA in cultured cerebellar granule neurones.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebellum; Cycloheximide; Cytoplasmic Granules; Dizocilpine Maleate; Glutamates; Glutamic Acid; N-Methylaspartate; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neurotransmitter Agents; Potassium Chloride; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stimulation, Chemical | 1993 |
Analysis of L-[3H]-glutamate radioligand binding to plasma membranes of the ampullae of Lorenzini of skates.
Topics: Animals; Cations; Cell Membrane; Electrophysiology; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Receptors, Glutamate; Skates, Fish; Synaptic Membranes | 1993 |
Characteristics of [3H]glutamate binding sites in rat cerebellum.
Topics: Animals; Binding Sites; Binding, Competitive; Cerebellum; Glutamates; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Species Specificity; Synaptic Membranes | 1993 |
The monosialoganglioside GM1 dose-dependently reduces regional cerebral metabolic rates for glucose in awake rats.
Topics: Animals; Aspartic Acid; Binding, Competitive; Brain; Dose-Response Relationship, Drug; G(M1) Ganglioside; Glucose; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Inbred F344 | 1993 |
Characterization of the glutamate receptors mediating release of somatostatin from cultured hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cells, Cultured; Cycloleucine; Dizocilpine Maleate; Drug Synergism; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Somatostatin; Tetrodotoxin | 1996 |
Serotonin 5-HT1D and 5-HT1A receptors respectively mediate inhibition of glutamate release and inhibition of cyclic GMP production in rat cerebellum in vitro.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Afferent Pathways; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebellum; Cyclic GMP; Glutamic Acid; Male; N-Methylaspartate; Oxadiazoles; Piperazines; Potassium; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1D; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Agents; Signal Transduction; Sumatriptan; Synapses; Synaptic Transmission | 1996 |
Stimulation of serotonin release in the rat brain cortex by activation of ionotropic glutamate receptors and its modulation via alpha 2-heteroreceptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Glutamate; Serotonin | 1995 |
On the probabilistic nature of excitotoxic neuronal death in hippocampal neurons.
Topics: Animals; Animals, Newborn; Cell Death; Cell Survival; Dizocilpine Maleate; Glutamic Acid; Hippocampus; In Vitro Techniques; Models, Neurological; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
Presynaptic actions of glutamate receptor agonists in the CA1 region of rat hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic | 1995 |
Lack of correlation between glutamate-induced depletion of ATP and neuronal death in primary cultures of cerebellum.
Topics: Adenosine Triphosphate; Animals; Arginine; Cell Death; Cells, Cultured; Cerebellum; Coloring Agents; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Neurons; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 1995 |
Excitatory amino acid induced currents of isolated murine hypothalamic neurons and their suppression by 2,3-butanedione monoxime.
Topics: Animals; Cholinesterase Reactivators; Diacetyl; Excitatory Amino Acids; Glutamic Acid; Hypothalamus; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred Strains; N-Methylaspartate; Patch-Clamp Techniques | 1995 |
N-methyl-D-aspartate transmission modulates GABAB-mediated inhibition of rat hippocampal pyramidal neurons in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-B Receptor Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Interneurons; N-Methylaspartate; Organophosphorus Compounds; Patch-Clamp Techniques; Piperazines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1995 |
Glutamate receptor agonists modulate [Ca2+]i in isolated rat melanotropes.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Fluorescent Dyes; Fura-2; Glutamic Acid; Glycine; Kainic Acid; Magnesium; Male; N-Methylaspartate; Pituitary Gland; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate | 1995 |
Hippocampal CA1 lacunosum-moleculare interneurons: comparison of effects of anoxia on excitatory and inhibitory postsynaptic currents.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electric Stimulation; Evoked Potentials; Glutamic Acid; Hippocampus; Hypoxia, Brain; Interneurons; Male; Membrane Potentials; N-Methylaspartate; Neural Inhibition; Purinergic P1 Receptor Antagonists; Pyramidal Cells; Rats; Rats, Wistar; Synaptic Transmission | 1995 |
Effects of repeated cold stress on aversive responses produced by intrathecal excitatory amino acids in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cold Temperature; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Stress, Psychological | 1995 |
In vivo electrochemical studies of the dynamic effects of locally applied excitatory amino acids in the striatum of the anesthetized rat.
Topics: Adolescent; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Cricetinae; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acids; Glutamic Acid; Humans; Kainic Acid; Male; N-Methylaspartate; Oxidation-Reduction; Potassium; Quinolinic Acid; Quisqualic Acid; Rats; Rats, Sprague-Dawley | 1996 |
Effects of inhalation anesthetics of Kainate-induced glutamate release from cerebellar granule cells.
Topics: Anesthetics, Inhalation; Animals; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Drug Interactions; Glutamic Acid; Kainic Acid; Kinetics; N-Methylaspartate; Neurons, Afferent; Rats; Rats, Sprague-Dawley | 1996 |
Nitric oxide regulates excitatory amino acid release in a biphasic manner in freely moving rats.
Topics: Animals; Arginine; Aspartic Acid; Enzyme Inhibitors; Excitatory Amino Acids; Glutamic Acid; Hippocampus; Male; Microdialysis; Motor Activity; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1995 |
Effects of decahydroisoquinoline-3-carboxylic acid monohydrate, a novel AMPA receptor antagonist, on glutamate-induced CA2+ responses and neurotoxicity in rat cortical and cerebellar granule neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cerebellum; Cerebral Cortex; Dose-Response Relationship, Drug; Glutamic Acid; Isoquinolines; Kainic Acid; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tetrazoles | 1995 |
Functional glutamate receptors in a subpopulation of anterior pituitary cells.
Topics: Animals; Calcium; Corticotropin-Releasing Hormone; Glutamic Acid; Gonadotropin-Releasing Hormone; Growth Hormone-Releasing Hormone; Kainic Acid; Male; N-Methylaspartate; Pituitary Gland, Anterior; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Thyrotropin-Releasing Hormone | 1996 |
The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Base Sequence; Cannabinoids; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Endocannabinoids; Ethanolamines; Glutamic Acid; In Situ Hybridization; Kinetics; Mice; Mice, Inbred BALB C; Models, Neurological; Molecular Sequence Data; N-Methylaspartate; Neurons; Neurotoxins; Oligonucleotide Probes; Palmitic Acids; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Time Factors | 1996 |
Decreased gonadotropin-releasing hormone neurosecretory response to glutamate agonists in middle-aged female rats on proestrus afternoon: a possible role in reproductive aging?
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arcuate Nucleus of Hypothalamus; Base Sequence; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Gonadotropin-Releasing Hormone; Kainic Acid; Luteinizing Hormone; Median Eminence; Molecular Sequence Data; N-Methylaspartate; Preoptic Area; Proestrus; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1996 |
Patch-clamp detection of neurotransmitters in capillary electrophoresis.
Topics: Animals; Biosensing Techniques; Electrophoresis, Capillary; gamma-Aminobutyric Acid; Glutamic Acid; Interneurons; Ion Channels; N-Methylaspartate; Olfactory Bulb; Patch-Clamp Techniques; Rats; Receptors, GABA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Sensitivity and Specificity | 1996 |
Excitatory amino acid-induced neuronal cell death in rat cerebellar granule cell cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Cells, Cultured; Cerebellum; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate | 1995 |
Ethanol-induced inhibition of [3H]thienylcyclohexylpiperidine (TCP) binding to NMDA receptors in brain synaptic membranes and to a purified protein complex.
Topics: Animals; Brain Chemistry; Dizocilpine Maleate; Dopamine Antagonists; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Haloperidol; Illicit Drugs; Kinetics; Male; Membrane Proteins; N-Methylaspartate; Phencyclidine; Protein Binding; Proteins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sensitivity and Specificity; Spermidine; Synaptic Membranes; Tritium | 1996 |
Sustained c-fos expression is associated with excitotoxicity during the development of neuronal cells in vitro.
Topics: Animals; Cells, Cultured; Cerebellum; Cerebral Cortex; Excitatory Amino Acids; Genes, fos; Glutamic Acid; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Neurons; Proto-Oncogene Proteins c-fos; RNA, Messenger; Transcription, Genetic | 1996 |
Photoperiod regulates the LH response to central glutamatergic stimulation in the male Syrian hamster.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cricetinae; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Gonadotropin-Releasing Hormone; Immunohistochemistry; Injections, Intraventricular; Luteinizing Hormone; Male; Mesocricetus; N-Methylaspartate; Photoperiod; Proto-Oncogene Proteins c-fos; Radioimmunoassay; Reproduction | 1993 |
Selective activation of calcium permeability by aspartate in Purkinje cells.
Topics: Animals; Aspartic Acid; Calcium; Cerebellum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Homocysteine; Magnesium; Mice; Mice, Knockout; N-Methylaspartate; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Permeability; Purkinje Cells; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate | 1996 |
Opposing effects on blood pressure following the activation of metabotropic and ionotropic glutamate receptors in raphe obscurus in the anaesthetized rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Benzoates; Blood Pressure; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hypertension; Male; Microinjections; N-Methylaspartate; Neurotoxins; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Structure-Activity Relationship; Valine | 1996 |
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors.
Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; Cerebral Cortex; Cricetinae; Cyclic AMP; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Kidney; Kinetics; Mice; N-Methylaspartate; Neuroglia; Neurons; Neurotoxins; Phosphatidylinositols; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 1996 |
Responses mediated by excitatory and inhibitory amino acid receptors in solitary spiking cells from normal newt retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Dose-Response Relationship, Drug; Glutamic Acid; Kainic Acid; N-Methylaspartate; Patch-Clamp Techniques; Receptors, Amino Acid; Retina; Salamandridae | 1995 |
Characterization of excitatory amino acid neurotoxicity in N-methyl-D-aspartate receptor-deficient mouse cortical neuronal cells.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Chimera; Female; Glutamic Acid; Membrane Potentials; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mice, Neurologic Mutants; N-Methylaspartate; Neurons; Neurotoxins; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Stem Cells; Transfection | 1996 |
Glutamate depresses release by activating non-conventional glutamate receptors at crayfish nerve terminals.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Astacoidea; Axons; Calcium; Cell Membrane; Electric Conductivity; Electric Stimulation; Fura-2; Glutamic Acid; Muscles; N-Methylaspartate; Nerve Endings; Perfusion; Quisqualic Acid; Receptors, Glutamate; Synapses; Time Factors | 1996 |
Functional neuroanatomy of the nigrostriatal and striatonigral pathways as studied with dual probe microdialysis in the awake rat--II. Evidence for striatal N-methyl-D-aspartate receptor regulation of striatonigral GABAergic transmission and motor functio
Topics: Animals; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Motor Activity; N-Methylaspartate; Neostriatum; Neural Pathways; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Synaptic Transmission; Tetrodotoxin | 1996 |
Glutamate receptor ion channel properties predict vulnerability to cytotoxicity in a transfected nonneuronal cell line.
Topics: 2-Amino-5-phosphonovalerate; Animals; Base Sequence; Benzothiadiazines; Cell Line; Cell Survival; Concanavalin A; Dizocilpine Maleate; DNA Primers; Evoked Potentials; Glutamic Acid; Humans; Ion Channels; Kainic Acid; Kidney; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylaspartate; Neurotoxins; Patch-Clamp Techniques; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Transfection | 1996 |
Mechanisms of glutamate-stimulated Mg2+ influx and subsequent Mg2+ efflux in rat forebrain neurones in culture.
Topics: Animals; Antiporters; Benzofurans; Brain; Cells, Cultured; Electrophysiology; Ethers, Cyclic; Fluorescent Dyes; Fura-2; Glutamic Acid; Gramicidin; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons; Potassium; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium | 1996 |
L-Glutamate-induced responses in OFF-type bipolar cells of the cat retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Calcium; Cats; Chlorides; Cycloleucine; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; In Vitro Techniques; Ion Transport; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Potassium; Retina; Retinal Cone Photoreceptor Cells; Sodium | 1996 |
Polyamine amides are neuroprotective in cerebellar granule cell cultures challenged with excitatory amino acids.
Topics: Amides; Animals; Arthropod Venoms; Calcium; Cells, Cultured; Cerebellum; Excitatory Amino Acid Agonists; Glutamic Acid; Indoleacetic Acids; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Phenols; Phenylacetates; Polyamines; Potassium; Rats; Rats, Wistar; Spider Venoms | 1996 |
Glutamate release evoked by glutamate receptor agonists in cultured chick retina cells: modulation by arachidonic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Benzofurans; Calcium Chloride; Cells, Cultured; Chick Embryo; Ethers, Cyclic; Excitatory Amino Acid Agonists; Fluorescent Dyes; Glutamic Acid; Indoles; Kainic Acid; Kinetics; N-Methylaspartate; Receptors, Glutamate; Retina; Sodium; Spectrometry, Fluorescence | 1996 |
The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits.
Topics: Animals; Cerebral Cortex; Female; Glutamic Acid; Glycine; Kainic Acid; Macromolecular Substances; Membrane Potentials; N-Methylaspartate; Nerve Tissue Proteins; Oocytes; Polymerase Chain Reaction; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA, Messenger; Xenopus laevis | 1996 |
Origin of aspartate-induced responses in rat cerebellar Purkinje cells.
Topics: Animals; Aspartic Acid; Glutamic Acid; Interneurons; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Purkinje Cells; Rats; Receptors, N-Methyl-D-Aspartate | 1996 |
High-field MRS studies in brain slices.
Topics: Animals; Cerebral Cortex; Culture Techniques; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Guinea Pigs; Ion Channels; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Membrane Potentials; N-Methylaspartate; Neurotransmitter Agents; Synaptic Transmission | 1995 |
The sensitivity of N-methyl-D-aspartate receptors to lead inhibition is dependent on the receptor subunit composition.
Topics: Animals; Dose-Response Relationship, Drug; Female; Glutamic Acid; Lead; N-Methylaspartate; Oocytes; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 1996 |
Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors.
Topics: Animals; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; N-Methylaspartate; Piperidines; Receptors, N-Methyl-D-Aspartate; Xenopus | 1996 |
An early loss in membrane protein kinase C activity precedes the excitatory amino acid-induced death of primary cortical neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Cell Membrane; Cerebral Cortex; Excitatory Amino Acids; Glutamic Acid; N-Methylaspartate; Neurons; Protein Kinase C; Rats; Rats, Sprague-Dawley | 1996 |
Lateral hypothalamic NMDA receptors and glutamate as physiological mediators of eating and weight control.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Body Weight; Circadian Rhythm; Eating; Excitatory Amino Acid Antagonists; Food Deprivation; Glutamic Acid; Hypothalamic Area, Lateral; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 1996 |
Endogenous gamma-L-glutamylglutamate is a partial agonist at the N-methyl-D-aspartate receptors in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cells, Cultured; Cerebellum; Dipeptides; Drug Synergism; Glutamates; Glutamic Acid; Glycine; Magnesium; N-Methylaspartate; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1995 |
Ca2+ influx through glutamate receptor-associated channels in retina cells correlates with neuronal cell death.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Calcium Channels; Cell Death; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neuroprotective Agents; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Retina | 1996 |
Acamprosate (calcium acetylhomotaurinate) enhances the N-methyl-D-aspartate component of excitatory neurotransmission in rat hippocampal CA1 neurons in vitro.
Topics: Acamprosate; Alcohol Deterrents; Animals; Evoked Potentials; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Taurine | 1996 |
Regulation of rhythmic movements by purinergic neurotransmitters in frog embryos.
Topics: Adenosine; Adenosine Triphosphate; Animals; Calcium; Culture Techniques; Embryo, Nonmammalian; Glutamic Acid; Ion Channel Gating; Motor Neurons; Movement; N-Methylaspartate; Potassium; Purinergic P1 Receptor Antagonists; Pyridoxal Phosphate; Receptors, Purinergic P1; Receptors, Purinergic P2; Spinal Cord; Suramin; Swimming; Synapses; Theophylline; Xenopus | 1996 |
Glutamate receptor regulation of rat nucleus accumbens neurons in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Excitatory Amino Acid Agonists; Glutamic Acid; In Vitro Techniques; Iontophoresis; Male; Membrane Potentials; N-Methylaspartate; Neurons; Nucleus Accumbens; Patch-Clamp Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate | 1996 |
Aging reduces neostriatal responsiveness to N-methyl-D-aspartate and dopamine: an in vitro electrophysiological study.
Topics: Age Factors; Aging; Animals; Cats; Dopamine; Dose-Response Relationship, Drug; Evoked Potentials; Glutamic Acid; In Vitro Techniques; Male; N-Methylaspartate; Neostriatum; Rats; Rats, Inbred F344 | 1996 |
Regulation of growth hormone secretion by amino acid neurotransmitters in the goldfish (I): Inhibition by N-methyl-D, L-aspartic acid.
Topics: Animals; Estradiol; Glutamic Acid; Goldfish; Growth Hormone; Immunohistochemistry; Injections, Intraventricular; N-Methylaspartate; Pituitary Gland | 1996 |
Developmental changes in glutamate receptor-activated translocation of protein kinase C in cerebellar granule neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Biological Transport; Carcinogens; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurotoxins; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Tritium | 1996 |
Postsynaptic modulation of NMDA synaptic currents in rat hippocampal microcultures by paired-pulse stimulation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Electrophysiology; Excitatory Amino Acid Agonists; GABA Agonists; Glutamic Acid; Hippocampus; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Synapses | 1996 |
Pharmacology of N-methyl-D-aspartate-evoked [3H]noradrenaline release in adult rat spinal cord.
Topics: Animals; Aspartic Acid; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tritium | 1996 |
NMDA receptor-mediated cGMP synthesis in primary cultures of mouse cerebellar granule cells appears to involve neuron-astrocyte communication with NO operating as the intercellular messenger.
Topics: Animals; Astrocytes; Calcimycin; Calcium; Calcium Channel Blockers; Cell Communication; Cells, Cultured; Cerebellum; Cyclic GMP; Excitatory Amino Acid Antagonists; Glutamate-Ammonia Ligase; Glutamic Acid; Hemoglobins; Kinetics; Magnesium; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Nifedipine; Nitric Oxide; Nitroarginine; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Verapamil | 1996 |
An NMDA receptor on isolated secretory nerve endings.
Topics: Animals; Calcium; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamic Acid; Male; N-Methylaspartate; Nerve Endings; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1995 |
Sustained exposure to 1-aminocyclopropanecarboxylic acid, a glycine partial agonist, alters N-methyl-D-aspartate receptor function and subunit composition.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Calcium; Cell Death; Cerebellum; Cyclic GMP; Cytoplasmic Granules; Drug Synergism; Glutamic Acid; Glycine; Macromolecular Substances; Mice; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA; Stimulation, Chemical | 1995 |
omega-agatoxin IVA and excitotoxicity in cortical neuronal cultures.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Survival; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Neurons; Neurotoxins; omega-Agatoxin IVA; Ouabain; Rats; Rats, Sprague-Dawley; Spider Venoms; Veratridine | 1996 |
Inhibition of crossed caudal interneurons by lateral interneurons in lamprey spinal chord during fictive locomotion.
Topics: Animals; Glutamic Acid; Interneurons; Lampreys; Locomotion; Membrane Potentials; N-Methylaspartate; Nerve Net; Spinal Cord; Swimming; Tail | 1995 |
Reduced glucose metabolism enhances the glutamate-evoked release of arachidonic acid from striatal neurons.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Corpus Striatum; Dose-Response Relationship, Drug; Glucose; Glutamic Acid; Lactic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Pyruvic Acid | 1996 |
Involvement of nigral glutamatergic inputs in the control of seizures in a genetic model of absence epilepsy in the rat.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Epilepsy, Absence; Glutamic Acid; Male; Microinjections; N-Methylaspartate; Rats; Rats, Wistar; Substantia Nigra | 1996 |
Muscle NMDA receptors regulate the resting membrane potential through NO-synthase.
Topics: 2-Amino-5-phosphonovalerate; Animals; Diaphragm; Glutamic Acid; Male; Membrane Potentials; Muscle Denervation; Muscles; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1995 |
Thyrotropin-releasing hormone (TRH) attenuates glutamate-stimulated increases in calcium in primary neuronal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cells, Cultured; Cycloleucine; Electrophysiology; Glutamic Acid; Intracellular Membranes; Ion Channel Gating; N-Methylaspartate; Neurons; Rats; Thyrotropin-Releasing Hormone | 1996 |
Stimulation of glutamine synthetase activity by excitatory amino acids in astrocyte cultures derived from aged mouse cerebral hemispheres may be associated with non-N-methyl-D-aspartate receptor activation.
Topics: 2-Amino-5-phosphonovalerate; Aging; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Cell Division; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamate-Ammonia Ligase; Glutamic Acid; Mice; N-Methylaspartate; Neurotoxins; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 1996 |
Involvement of nitric oxide in spinally mediated capsaicin- and glutamate-induced behavioural responses in the mouse.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Receptors, Tachykinin; Spinal Cord | 1996 |
Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells.
Topics: Binding, Competitive; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ion Channels; Kidney; Kinetics; Memantine; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transfection | 1996 |
Sequestration of glutamate-induced Ca2+ loads by mitochondria in cultured rat hippocampal neurons.
Topics: Animals; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Excitatory Amino Acid Agonists; Glutamic Acid; Glycolysis; Hippocampus; Image Processing, Computer-Assisted; L-Lactate Dehydrogenase; Mitochondria; N-Methylaspartate; Neurons; Photometry; Rats; Sodium Channels; Uncoupling Agents | 1996 |
Glutamate receptor agonists decrease extracellular dopamine in the rat nucleus accumbens in vivo.
Topics: Animals; Dopamine; Dose-Response Relationship, Drug; Glutamic Acid; Male; Microdialysis; N-Methylaspartate; Nucleus Accumbens; Rats; Rats, Wistar | 1996 |
Effect of glutamate receptor ligands on mitochondrial membrane potential in rat dissociated cerebellar cells.
Topics: Animals; Animals, Newborn; Calcium; Cerebellum; Fluorescent Dyes; Glutamic Acid; In Vitro Techniques; Kainic Acid; Ligands; Membrane Potentials; Mitochondria; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Rhodamine 123; Rhodamines; Sodium; Spectrometry, Fluorescence | 1996 |
Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Astrocytes; Biological Transport; Biomarkers; Cell Death; Cells, Cultured; Dizocilpine Maleate; Drug Synergism; Enzyme Induction; Excitatory Amino Acid Antagonists; Glutamate-Ammonia Ligase; Glutamic Acid; Humans; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; L-Lactate Dehydrogenase; Models, Biological; N-Methylaspartate; Nerve Tissue Proteins; Neuroglia; Neurons; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sialoglycoproteins; Tumor Necrosis Factor-alpha | 1995 |
Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation.
Topics: Animals; Aspirin; Calcium; Cell Survival; Cells, Cultured; Cerebellum; Dentate Gyrus; Glutamic Acid; Hippocampus; In Vitro Techniques; N-Methylaspartate; Neurons; Neuroprotective Agents; NF-kappa B; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Sodium Salicylate; Transcription Factor AP-1; Up-Regulation | 1996 |
Tachycardia after glutamate injection in rat spinal cord is not blocked by kynurenate or mimicked by metabotropic agonists.
Topics: Aminobutyrates; Analysis of Variance; Animals; Blood Pressure; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Injections, Spinal; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred WKY; Receptors, Metabotropic Glutamate; Spinal Cord; Tachycardia | 1996 |
Biphasic effect of taurine on excitatory amino acid-induced neurotoxicity.
Topics: Animals; Brain; Cells, Cultured; Excitatory Amino Acid Agonists; Fetus; Glutamic Acid; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Taurine | 1996 |
Balanced interaction of growth factors and taurine regulate energy metabolism, neuronal survival, and function of cultured mouse cerebellar cells under depolarizing conditions.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Calcium; Cell Survival; Cells, Cultured; Cerebellum; Culture Media, Serum-Free; Energy Metabolism; Glutamic Acid; Growth Substances; Membrane Potentials; Mice; Mitochondria; N-Methylaspartate; Neurons; Potassium; Taurine | 1996 |
Potentiation of spontaneous acetylcholine release from motor nerve terminals by glutamate in Xenopus tadpoles.
Topics: Acetylcholine; Alanine; Animals; Calcium; Calcium Channel Blockers; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Larva; Motor Endplate; N-Methylaspartate; Neurotoxins; Quisqualic Acid; Second Messenger Systems; Verapamil; Xenopus laevis | 1996 |
Glutamate-dependent mechanisms in the induction of a calcium long-term potentiation-like phenomenon.
Topics: Alanine; Animals; Brain Chemistry; Calcium; Cyclazocine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Long-Term Potentiation; Male; N-Methylaspartate; Narcotic Antagonists; Pipecolic Acids; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 1996 |
Glutamate as a putative neurotransmitter in the mollusc, Lymnaea stagnalis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanosine Diphosphate; Kainic Acid; Lymnaea; Membrane Potentials; N-Methylaspartate; Nervous System Physiological Phenomena; Neurons; Neuropeptides; Neurotransmitter Agents; Patch-Clamp Techniques; Quisqualic Acid; Synapses; Thionucleotides | 1996 |
Excitatory amino acid regulation of astrocyte proteoglycans.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; CD57 Antigens; Cell Membrane; Cells, Cultured; Chondroitin Sulfates; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Heparitin Sulfate; Hippocampus; Immunohistochemistry; Kainic Acid; N-Methylaspartate; Protein Kinase C; Rats; Receptors, Metabotropic Glutamate; Subcellular Fractions; Sulfates; Sulfur Radioisotopes | 1996 |
Copper modulation of NMDA responses in mouse and rat cultured hippocampal neurons.
Topics: Animals; Animals, Newborn; Cells, Cultured; Copper; Embryo, Mammalian; Glutamic Acid; Glycine; Hippocampus; Membrane Potentials; Mice; Mice, Inbred BALB C; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Zinc | 1996 |
Glial regulation of alpha 7-type nicotinic acetylcholine receptor expression in cultured rat cortical neurons.
Topics: Animals; Bungarotoxins; Cell Count; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Floxuridine; Glutamic Acid; In Situ Hybridization; N-Methylaspartate; Neuroglia; Neurons; Rats; Receptors, Nicotinic; RNA, Messenger | 1997 |
Flupirtine increases the levels of glutathione and Bc1-2 in hNT (human Ntera/D1) neurons: mode of action of the drug-mediated anti-apoptotic effect.
Topics: Aminopyridines; Analgesics, Non-Narcotic; Apoptosis; Cell Line; DNA Fragmentation; Excitatory Amino Acid Agonists; Glutamic Acid; Glutathione; Humans; Immunohistochemistry; N-Methylaspartate; Neurons; Proto-Oncogene Proteins c-bcl-2 | 1996 |
Hypoxic and excitotoxic damage to cultured rat retinal ganglion cells.
Topics: Animals; Astrocytes; Cell Culture Techniques; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamic Acid; Hypoxia; N-Methylaspartate; Neuroglia; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Time Factors | 1996 |
Dopamine enhancement and depression of glutamate-regulated calcium and electrical activity in hypothalamic neurons.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Dopamine; Excitatory Amino Acid Agonists; Fluorescent Dyes; Fura-2; Glutamic Acid; Hypothalamus; Kainic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tetrodotoxin | 1996 |
Resetting the biological clock: mediation of nocturnal CREB phosphorylation via light, glutamate, and nitric oxide.
Topics: 2-Amino-5-phosphonovalerate; Animals; Circadian Rhythm; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Gene Expression Regulation; Glutamic Acid; Light; N-Methylaspartate; NADPH Dehydrogenase; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Phosphorylation; Photic Stimulation; Protein Processing, Post-Translational; Rats; Rats, Inbred Strains; Suprachiasmatic Nucleus; Time Factors; Transcription, Genetic | 1997 |
Opioid effects on 45Ca2+ uptake and glutamate release in rat cerebral cortex in primary culture.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Biological Transport; Calcium Radioisotopes; Cells, Cultured; Cerebral Cortex; Dynorphins; Excitatory Amino Acid Agonists; Female; Fetus; Glutamic Acid; Homeostasis; Membrane Potentials; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Oligopeptides; Potassium; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1997 |
Assessment of neuronal viability with Alamar blue in cortical and granule cell cultures.
Topics: Animals; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebellum; Cerebral Cortex; Coloring Agents; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glucose; Glutamic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neurotoxins; Nitroprusside; Oxazines; Potassium; Rats; Rats, Sprague-Dawley; Vasodilator Agents; Xanthenes | 1996 |
gp120, a human immunodeficiency virus-1 coat protein, augments excitotoxic hippocampal injury in perinatal rats.
Topics: Animals; Animals, Newborn; Autoradiography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; HIV Envelope Protein gp120; Injections; Male; N-Methylaspartate; Neurotoxins; Piperazines; Pyrrolidinones; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Protection by diphenyliodonium against glutamate neurotoxicity due to blocking of N-methyl-D-aspartate receptors.
Topics: Animals; Biphenyl Compounds; Calcium; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Neurons; Nitric Oxide Synthase; Onium Compounds; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1997 |
Characterization of glutamate toxicity in cultured rat cerebellar granule neurons at reduced temperature.
Topics: Animals; Cell Count; Cells, Cultured; Cerebellum; Cold Temperature; Drug Synergism; Glutamic Acid; Glycine; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Alpha-adrenergic receptor antagonism and N-methyl-D-aspartate (NMDA) induced luteinizing hormone release in female rhesus macaques.
Topics: Adrenergic alpha-Antagonists; Animals; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Idazoxan; Immunohistochemistry; In Situ Hybridization; Locus Coeruleus; Luteal Phase; Luteinizing Hormone; Macaca mulatta; N-Methylaspartate; Prazosin; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tyrosine 3-Monooxygenase | 1997 |
Effects of excitatory amino acids and neuropeptide Y on the discharge activity of suprachiasmatic neurons in rat brain slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Circadian Rhythm; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine Agents; Male; N-Methylaspartate; Neurons; Neuropeptide Y; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Strychnine; Suprachiasmatic Nucleus | 1997 |
High extracellular glycine does not potentiate N-methyl-D-aspartate-evoked depolarization in vivo.
Topics: Animals; Electroencephalography; Electrophysiology; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; Glycine; Male; Membrane Potentials; Microdialysis; N-Methylaspartate; Neostriatum; Neurons; Neurotoxins; Perfusion; Rats; Rats, Sprague-Dawley | 1997 |
Glutamate and N-methyl-D-aspartate stimulate rat hypothalamic corticotropin-releasing factor secretion in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corticotropin-Releasing Hormone; Culture Techniques; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Hypothalamus; Kainic Acid; Male; N-Methylaspartate; Potassium Chloride; Rats; Rats, Wistar | 1997 |
Calretinin-containing neurons in rat cerebellar granule cell cultures.
Topics: Animals; Calbindin 2; Calcium; Cells, Cultured; Cerebellum; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Rats; Rats, Sprague-Dawley; Ribonucleases; RNA, Messenger; S100 Calcium Binding Protein G | 1997 |
Release of dopamine in the nucleus accumbens caused by stimulation of the subiculum in freely moving rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Dopamine; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Homovanillic Acid; Locomotion; Male; Microdialysis; N-Methylaspartate; Nucleus Accumbens; Rats; Rats, Wistar | 1997 |
AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazolol bioisosteres of glutamic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Glutamic Acid; Mice; N-Methylaspartate; Rats; Receptors, AMPA; Receptors, Kainic Acid; Thiazoles | 1997 |
Simultaneous measurement of nitrite and nitrate levels as indices of nitric oxide release in the cerebellum of conscious rats.
Topics: Animals; Arginine; Calcium; Cerebellum; Enzyme Inhibitors; Extracellular Space; Glutamic Acid; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Rats, Wistar | 1997 |
N-methyl-D-aspartate-mediated glutamate toxicity in the developing rabbit retina.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Cell Death; Cyclic GMP; Dextromethorphan; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rabbits; Receptors, N-Methyl-D-Aspartate; Retina | 1997 |
A novel NMDA receptor antagonist protects against N-methyl-D-aspartate- and glutamate-induced neurotoxicity in the goldfish retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Drug Interactions; Glutamic Acid; Goldfish; Hippocampus; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Diseases | 1997 |
Hippocampal N-methyl-D-aspartate and kainate binding in response to entorhinal cortex aspiration or 192 IgG-saporin lesions of the basal forebrain.
Topics: Acetylcholinesterase; Aging; Animals; Antibodies, Monoclonal; Cholinergic Agents; Entorhinal Cortex; Glutamic Acid; Hippocampus; Immunotoxins; Kainic Acid; Kinetics; Male; N-Glycosyl Hydrolases; N-Methylaspartate; Neurons; Prosencephalon; Pyramidal Tracts; Radioligand Assay; Rats; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Ribosome Inactivating Proteins, Type 1; Saporins; Tritium | 1997 |
Effect of a prolonged glutamate challenge on plasmalemmal calcium permeability in mammalian central neurones. Mn2+ as a tool to study calcium influx pathways.
Topics: Animals; Calcium; Calcium Channels; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Membrane Permeability; Cells, Cultured; Cerebellum; Chelating Agents; Egtazic Acid; Fluorescence; Glutamic Acid; Ionophores; Manganese; N-Methylaspartate; Neurons; Nickel; Rats; Rats, Wistar | 1996 |
Evidence that the early loss of membrane protein kinase C is a necessary step in the excitatory amino acid-induced death of primary cortical neurons.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzophenanthridines; Calcium; Carcinogens; Cell Death; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Fetus; Gene Expression; Glutamic Acid; Kainic Acid; Membrane Proteins; N-Methylaspartate; Naphthalenes; Neurons; Phenanthridines; Potassium Chloride; Pregnancy; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Duality of glutamatergic and GABAergic control of pulsatile GnRH secretion by rat hypothalamic explants: I. Effects of antisense oligodeoxynucleotides using explants including or excluding the preoptic area.
Topics: Animals; Base Sequence; gamma-Aminobutyric Acid; Glutamic Acid; Gonadotropin-Releasing Hormone; Hypothalamus; Male; Molecular Sequence Data; Muscimol; N-Methylaspartate; Oligonucleotides, Antisense; Periodicity; Preoptic Area; Rats; Receptors, GABA; Receptors, N-Methyl-D-Aspartate | 1997 |
Distribution and projection of the medullary cardiovascular control neurons containing glutamate, glutamic acid decarboxylase, tyrosine hydroxylase and phenylethanolamine N-methyltransferase in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Axonal Transport; Blood Pressure; Cardiovascular System; Electric Stimulation; Glutamate Decarboxylase; Glutamic Acid; Glycine; Heart Rate; Male; Medulla Oblongata; Microelectrodes; N-Methylaspartate; Neurons; Phenylethanolamine N-Methyltransferase; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate | 1997 |
Pressor and sympathetic responses to excitatory amino acids are not augmented in the ventrolateral medulla of Dahl salt-sensitive rats.
Topics: Analysis of Variance; Animals; Blood Pressure; Body Weight; Cycloleucine; Diet, Sodium-Restricted; Excitatory Amino Acid Agonists; Glutamic Acid; Heart Rate; Male; Medulla Oblongata; Microinjections; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Inbred Strains; Sodium, Dietary; Splanchnic Circulation; Sympathetic Nervous System | 1997 |
Modulation of histamine release in the hypothalamus by nitric oxide.
Topics: Animals; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Histamine Release; Hypothalamus; Kinetics; Male; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptors, Histamine H3 | 1997 |
Differential regulation of neuronal proteoglycans by activation of excitatory amino acid receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Chondroitin Sulfate Proteoglycans; Cycloleucine; DNA Primers; Excitatory Amino Acid Agonists; Fetus; Glutamic Acid; Glycosylphosphatidylinositols; Glypicans; Heparan Sulfate Proteoglycans; Hippocampus; Lectins, C-Type; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurocan; Neurons; Neuroprotective Agents; Polymerase Chain Reaction; Proteoglycans; Rats; Receptors, Glutamate; RNA, Messenger; Transcription, Genetic | 1997 |
NMDA receptor-mediated neurotoxicity: a paradoxical requirement for extracellular Mg2+ in Na+/Ca2+-free solutions in rat cortical neurons in vitro.
Topics: Animals; Cerebral Cortex; Culture Techniques; Excitatory Amino Acid Agonists; Glutamic Acid; Magnesium; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Increased production of extracellular glutamate by the mitochondrial glutaminase following neuronal death.
Topics: 4-Chloromercuribenzenesulfonate; Animals; Cell Compartmentation; Cell Death; Cells, Cultured; Cerebral Cortex; Culture Techniques; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Glutaminase; Glutamine; Mice; Mitochondria; Models, Biological; N-Methylaspartate; Neuroglia; Neurons | 1997 |
Mechanisms for regulating synaptic efficiency in the visual cortex.
Topics: Algorithms; Animals; Cats; Evoked Potentials; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Mental Processes; N-Methylaspartate; Neurons; Nitric Oxide; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptosomes; Up-Regulation; Visual Cortex | 1996 |
Glutamatergic dysfunction in catatonia? Successful treatment of three acute akinetic catatonic patients with the NMDA antagonist amantadine.
Topics: Adult; Amantadine; Catatonia; Glutamic Acid; Humans; Infusions, Intravenous; Male; N-Methylaspartate | 1997 |
Possible involvement of nitric oxide in NMDA-induced glutamate release in the rat striatum: an in vivo microdialysis study.
Topics: Animals; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Microdialysis; N-Methylaspartate; Neostriatum; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; o-Phthalaldehyde; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 1997 |
Local synaptic release of glutamate from neurons in the rat hypothalamic arcuate nucleus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Arcuate Nucleus of Hypothalamus; Calcium Channels; Cells, Cultured; Excitatory Amino Acid Antagonists; Glutamic Acid; Models, Neurological; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Tetrodotoxin | 1997 |
Spontaneous bursting activity of dopaminergic neurons in midbrain slices from immature rats: role of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; Dopamine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Male; Mesencephalon; N-Methylaspartate; Neurons; Periodicity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Specific [3H]glutamate binding in the cerebral cortex and hippocampus of rats during development: effect of homocysteine-induced seizures.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Binding Sites; Cerebral Cortex; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Reference Values; Seizures; Synaptic Membranes; Tritium | 1997 |
Regulation of cerebral microvessels by glutamatergic mechanisms.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Cerebrovascular Circulation; Cycloleucine; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Microcirculation; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synapses; Vasoconstriction; Vasodilation | 1997 |
Mitochondrial membrane potential measurement in rat cerebellar neurons by flow cytometry.
Topics: Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cerebellar Cortex; Deoxyglucose; Flow Cytometry; Fluorescent Dyes; Glucose; Glutamic Acid; Gramicidin; Hydrogen Peroxide; Ionomycin; Ionophores; Membrane Potentials; Microscopy, Confocal; Mitochondria; N-Methylaspartate; Neurons; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Rhodamine 123; Rhodamines; Valinomycin | 1997 |
Secondary activation of a cation conductance is responsible for NMDA toxicity in acutely isolated hippocampal neurons.
Topics: Animals; Calcium; Cations; Cell Death; Electric Conductivity; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Membrane Potentials; N-Methylaspartate; Neurons; Neurotoxins; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Sodium | 1997 |
Age dependent sensitivity of the rat retina to the excitotoxic action of N-methyl-D-aspartate.
Topics: Age Factors; Aging; Animals; Excitatory Amino Acid Agonists; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retina | 1995 |
Effects of excitatory amino acids on cerebral oxygen consumption and blood flow in rat.
Topics: Animals; Brain; Cerebrovascular Circulation; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; N-Methylaspartate; Oxygen Consumption; Rats | 1997 |
Acute rise in the concentration of free cytoplasmic calcium leads to dephosphorylation of the microtubule-associated protein tau.
Topics: Analysis of Variance; Animals; Calcium; Cells, Cultured; Cerebellum; Cerebral Cortex; Cytoplasm; Embryo, Mammalian; Glutamic Acid; Ionomycin; Mice; N-Methylaspartate; Neurons; Okadaic Acid; Phosphoprotein Phosphatases; Potassium Chloride; Protein Phosphatase 1; Pyrethrins; Rats; tau Proteins | 1997 |
Role of histidyl residues in the binding of ligands to the porcine N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Cerebral Cortex; Diethyl Pyrocarbonate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Histidine; Ionophores; Kainic Acid; Ligands; N-Methylaspartate; Piperazines; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Swine; Synaptic Membranes; Tritium | 1997 |
Association of c-fos mRNA expression and excitotoxicity in primary cultures of mouse neocortical and cerebellar neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Cells, Cultured; Cerebellar Cortex; Cerebral Cortex; Cysteine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Genes, fos; Glutamic Acid; Kainic Acid; Mice; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Proto-Oncogene Proteins c-fos; RNA, Messenger | 1997 |
[Nitric oxide (NO) increase sensitivity and decreases desensitization of the neuron to the stimulating effect of glutamate].
Topics: Animals; Enzyme Inhibitors; Glutamic Acid; Guanylate Cyclase; Helix, Snails; In Vitro Techniques; N-Methylaspartate; NADPH Dehydrogenase; Neurons; Nitric Oxide; Nitric Oxide Synthase | 1997 |
Role of the dorso-caudal neostriatum in filial imprinting of the domestic chick: a pharmacological and autoradiographical approach focused on the involvement of NMDA-receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Chickens; Densitometry; Deoxyglucose; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorodeoxyglucose F18; Glutamic Acid; Imprinting, Psychological; Injections, Intraventricular; Ligands; N-Methylaspartate; Neostriatum; Receptors, N-Methyl-D-Aspartate | 1997 |
Glutamate-evoked currents in acutely dissociated neurons from the rat medial preoptic nucleus.
Topics: Animals; Evoked Potentials; Glutamic Acid; Male; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Preoptic Area; Rats; Rats, Sprague-Dawley | 1997 |
Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells.
Topics: Animals; Apoptosis; Calcimycin; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebellum; Enzyme Activation; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Ionophores; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; N-Methylaspartate; p38 Mitogen-Activated Protein Kinases; Rats; Signal Transduction | 1997 |
Glutamate-dependent activation of NF-kappaB during mouse cerebellum development.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Age Factors; Animals; Antibody Specificity; Cell Nucleus; Cerebellum; Cycloleucine; Cytoplasm; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Developmental; Glutamic Acid; Injections, Intraperitoneal; Mice; Mice, Transgenic; N-Methylaspartate; Neuroprotective Agents; Neurotransmitter Agents; NF-kappa B; Transgenes | 1997 |
Homocysteine signal cascade: production of phospholipids, activation of protein kinase C, and the induction of c-fos and c-myb in smooth muscle cells.
Topics: Aorta, Abdominal; Aorta, Thoracic; Cardiovascular Diseases; Cell Division; Diglycerides; Dizocilpine Maleate; DNA; Enzyme Activation; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Genes, fos; Glutamic Acid; Homocysteine; Humans; Immunoblotting; Muscle, Smooth, Vascular; N-Methylaspartate; Oncogenes; Pipecolic Acids; Polymerase Chain Reaction; Precipitin Tests; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; RNA | 1997 |
Regulation of GABA release via NMDA and 5-HT1A receptors in guinea pig dentate gyrus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Calcium; Chromatography, High Pressure Liquid; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Guinea Pigs; Magnesium; Male; N-Methylaspartate; Neurons; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Tetrodotoxin | 1997 |
Proline-induced potentiation of glutamate transmission.
Topics: 2-Amino-5-phosphonovalerate; Animals; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Long-Term Potentiation; N-Methylaspartate; Neuronal Plasticity; Organ Culture Techniques; Proline; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1997 |
Media composition modulates excitatory amino acid-induced death of rat cerebellar granule cells.
Topics: Animals; Area Under Curve; Calcium; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Culture Media; Culture Media, Serum-Free; Cytosol; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Granulocytes; Mitochondria; N-Methylaspartate; Oxidoreductases; Rats; Rats, Sprague-Dawley | 1997 |
Influences of excitatory amino acid receptor agonists on nucleus of the solitary tract neurons receiving aortic depressor nerve inputs.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aorta; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Nervous System Physiological Phenomena; Neurons; Rats; Rats, Sprague-Dawley; Solitary Nucleus | 1997 |
Reciprocal interaction between glutamate and dopamine in the pars reticulata of the rat substantia nigra: a microdialysis study.
Topics: Animals; Benzazepines; Carbachol; Dopamine; Dopamine Antagonists; Functional Laterality; gamma-Aminobutyric Acid; Glutamic Acid; Kinetics; Male; Microdialysis; Microinjections; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Dopamine D1; Substantia Nigra; Thalamic Nuclei | 1997 |
Glutamatergically induced pattern of Ca2+ driving potential as a mechanism of postsynaptic plasticity.
Topics: Animals; Calcium; Calcium Channels; Computer Simulation; Dendrites; Evoked Potentials; Glutamic Acid; Membrane Potentials; Models, Neurological; N-Methylaspartate; Neuronal Plasticity; Neurons; Potassium Channels; Receptors, Metabotropic Glutamate; Sodium Channels; Synapses; Synaptic Transmission | 1997 |
Dissociation of effects of glutamate receptor antagonists on excitotoxic and hypoxic neuronal cell death in a novel rat cortical culture system.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cytological Techniques; Glutamic Acid; Hypoxia; N-Methylaspartate; Neurons; Neurotoxins; Rats; Receptors, Glutamate | 1997 |
Characterization of a novel putative cognition enhancer mediating facilitation of glycine effect on strychnine-resistant sites coupled to NMDA receptor complex.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Nootropic Agents; Norepinephrine; Pentanoic Acids; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Spermine; Stereoisomerism | 1997 |
The effects of artificial calcium buffers on calcium responses and glutamate-mediated excitotoxicity in cultured hippocampal neurons.
Topics: Animals; Buffers; Calcium; Cells, Cultured; Egtazic Acid; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Neurotoxins; Potassium; Rats; Rats, Wistar | 1997 |
Dopamine function in the prefrontal cortex.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Dopamine; Dopamine Antagonists; Glutamic Acid; Models, Neurological; N-Methylaspartate; Neurons; Prefrontal Cortex; Pyramidal Cells; Quisqualic Acid; Rats; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1998 |
Effects of excitatory amino acids on neuromuscular development in the chick embryo.
Topics: Animals; Cell Death; Chick Embryo; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Extremities; Glutamic Acid; In Vitro Techniques; Motor Neurons; Muscle, Skeletal; N-Methylaspartate; Neuromuscular Junction; Spinal Cord; Synaptic Transmission | 1997 |
Nitric oxide synthase inhibitors do not attenuate diacylglycerol or monoacylglycerol lipase activities in synaptoneurosomes.
Topics: Animals; Brain; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Lipoprotein Lipase; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Synaptosomes | 1997 |
Excitotoxicity in the enteric nervous system.
Topics: Animals; Antibody Specificity; Apoptosis; Cells, Cultured; Enteric Nervous System; Excitatory Amino Acid Agonists; Ganglia; Glutamic Acid; Guinea Pigs; Kainic Acid; Male; Membrane Potentials; Mitochondria; N-Methylaspartate; Necrosis; Neurites; Neurons; Neurotoxins; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 1997 |
Effect of excitatory amino acids on rat hypothalamic somatostatin secretion in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Hypothalamus; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Potassium Chloride; Rats; Rats, Wistar; Receptors, Glutamate; Somatostatin | 1997 |
The effect of thiopental and propofol on NMDA- and AMPA-mediated glutamate excitotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Intravenous; Animals; Dimethyl Sulfoxide; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Propofol; Rats; Rats, Sprague-Dawley; Thiopental | 1997 |
Dendroaxonal transcytosis of transferrin in cultured hippocampal and sympathetic neurons.
Topics: Animals; Axonal Transport; Axons; Biological Transport; Cells, Cultured; Dendrites; Endocytosis; Fluorescent Dyes; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Image Processing, Computer-Assisted; Iron; Microscopy, Fluorescence; Microscopy, Video; N-Methylaspartate; Neurons; Rats; Receptors, Transferrin; Rhodamines; Superior Cervical Ganglion; Synaptic Transmission; Transferrin | 1997 |
Kainate excitotoxicity is mediated by AMPA- but not kainate-preferring receptors in embryonic rat hippocampal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Culture Media, Conditioned; Embryo, Mammalian; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Neurotoxins; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid | 1997 |
Glutamate stimulates 2-deoxyglucose uptake in rat cerebellar granule cells.
Topics: Animals; Cerebellum; Deoxyglucose; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Phosphorylation; Quisqualic Acid; Rats; Rats, Wistar; Temperature | 1997 |
Cardiovascular effects of nitric oxide and N-methyl-D-aspartate receptors in the nucleus tractus solitarii of rats.
Topics: Animals; Arginine; Blood Pressure; Brain Mapping; Brain Stem; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Male; Microinjections; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Solitary Nucleus | 1997 |
Intracellular free Ca2+ elevations in cultured astroglia induced by neuroligands playing a role in cerebral ischemia.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Astrocytes; Brain Ischemia; Calcium; Cells, Cultured; Cytoplasm; Excitatory Amino Acid Agonists; Extracellular Space; Fluorescent Dyes; Fura-2; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Quisqualic Acid; Rats; Receptors, Glutamate; Serotonin; Spectrometry, Fluorescence; Vasoconstrictor Agents; Vasopressins | 1997 |
Suppression of cyclic guanosine monophosphate formation in rat cerebellar slices by propofol, ketamine and midazolam.
Topics: Anesthetics, Intravenous; Animals; Cerebellum; Cyclic GMP; Depression, Chemical; Glutamic Acid; In Vitro Techniques; Ketamine; Midazolam; N-Methylaspartate; Nitroprusside; Propofol; Rats; Rats, Wistar; Vasodilator Agents | 1997 |
Effects of CO2 and pH on the spinal respiratory rhythm generator in vitro.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Animals, Newborn; Carbon Dioxide; Electrophysiology; Female; Glutamic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; N-Methylaspartate; Potassium; Rats; Rats, Sprague-Dawley; Respiration; Respiratory Center; Spinal Cord; Spinal Nerve Roots; Time Factors | 1998 |
N-methyl-D-aspartate receptor desensitisation is neuroprotective by inhibiting glutamate-induced apoptotic-like death.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Apoptosis; Calcineurin Inhibitors; Calcium; Cells, Cultured; Cerebellum; Chromatin; Cyclosporine; Excitatory Amino Acid Antagonists; Glutamic Acid; Kinetics; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
Aspartate as a selective NMDA receptor agonist in cultured cells from the avian retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Retina | 1998 |
Manipulations of glutamatergic (N-methyl-D-aspartate receptor) neurotransmission alter the rate of photoperiodically regulated sexual maturation in the male Siberian hamster.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Cricetinae; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Gonadotropin-Releasing Hormone; Male; N-Methylaspartate; Phodopus; Photoperiod; Receptors, N-Methyl-D-Aspartate; Sexual Maturation; Synaptic Transmission; Testis | 1998 |
Glycine increases arterial pressure and augments NMDA-induced pressor responses in the dorsomedial and ventrolateral medulla of cats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Cats; Dorsomedial Hypothalamic Nucleus; Drug Synergism; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Glycine; Kynurenic Acid; Male; Microinjections; N-Methylaspartate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Ventromedial Hypothalamic Nucleus | 1997 |
Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors.
Topics: Animals; Calcium; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Humans; Kidney; Kynurenic Acid; Membrane Potentials; Molecular Sequence Data; N-Methylaspartate; Oocytes; Patch-Clamp Techniques; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Xenopus laevis | 1998 |
Functional organization of rat olfactory bulb glomeruli revealed by optical imaging.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; Calcium; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Image Processing, Computer-Assisted; Male; N-Methylaspartate; Olfactory Bulb; Organ Culture Techniques; Organophosphorus Compounds; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Stimulation, Chemical; Tetrodotoxin | 1998 |
Modulation of GAP-43 mRNA by GABA and glutamate in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Blotting, Northern; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agonists; gamma-Aminobutyric Acid; GAP-43 Protein; Gene Expression Regulation, Developmental; Glial Fibrillary Acidic Protein; Glutamic Acid; Immunohistochemistry; In Situ Hybridization; Microtubule-Associated Proteins; Muscimol; N-Methylaspartate; Neurons; Neuroprotective Agents; Piperazines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1998 |
Quinolinic acid protects rat cerebellar granule cells from glutamate-induced apoptosis.
Topics: Animals; Apoptosis; Cerebellum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Logistic Models; N-Methylaspartate; Necrosis; Neurons; Neuroprotective Agents; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 1998 |
NMDA receptor modulation by a conditioned medium derived from rat cerebellar granule cells.
Topics: Animals; Cells, Cultured; Cerebellum; Culture Media, Conditioned; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression; Glutamic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tritium | 1997 |
Ethanol modulates N-methyl-D-aspartate-evoked arachidonic acid release from neurones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Cell Survival; Cells, Cultured; Central Nervous System Depressants; Corpus Striatum; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Excitatory Amino Acid Agonists; Glutamic Acid; Mice; N-Methylaspartate; Neurons | 1997 |
Networks of coactive neurons in developing layer 1.
Topics: Acetylcholine; Adrenergic alpha-Agonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cerebral Cortex; Electric Stimulation; Excitatory Amino Acid Agonists; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Muscimol; N-Methylaspartate; Neurons; Neurotransmitter Agents; Norepinephrine; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tetrodotoxin; Time Factors | 1998 |
Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons.
Topics: Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Intracellular Fluid; Kainic Acid; N-Methylaspartate; Neurons; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Sodium-Calcium Exchanger; Thiourea | 1998 |
N-acetyl-serotonin (normelatonin) and melatonin protect neurons against oxidative challenges and suppress the activity of the transcription factor NF-kappaB.
Topics: Animals; Cell Survival; Cerebellar Nuclei; Electrophoresis, Polyacrylamide Gel; Glutamic Acid; Hydrogen Peroxide; Melatonin; N-Methylaspartate; Neuroblastoma; Neurons; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Serotonin; Tumor Cells, Cultured | 1998 |
Hypoxia-tolerant neonatal CA1 neurons: relationship of survival to evoked glutamate release and glutamate receptor-mediated calcium changes in hippocampal slices.
Topics: Aging; Animals; Animals, Newborn; Calcium; Cell Hypoxia; Cell Survival; Cytosol; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley | 1998 |
Glutamate triggers cell death specifically in mature central neurons through a necrotic process.
Topics: Animals; Cell Death; Cells, Cultured; Embryo, Mammalian; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Necrosis; Nerve Tissue Proteins; Neurons; Prosencephalon; Rats; Rats, Sprague-Dawley; Time Factors | 1998 |
Prenatal ethanol exposure enhances glutamate release stimulated by quisqualate in rat cerebellar granule cell cultures.
Topics: Alcoholism; Amino Acids; Animals; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Ethanol; Female; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Potassium Chloride; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1998 |
Comparison of glutamate and N-methyl-D-aspartate toxicities on rat mesencephalic primary cell cultures.
Topics: Animals; Cells, Cultured; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Logistic Models; N-Methylaspartate; Neurons; Neuroprotective Agents; Phencyclidine; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1997 |
Suppression of sprouting: An early function of NMDA receptors in the absence of AMPA/kainate receptor activity.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Axons; Cells, Cultured; Chelating Agents; Dizocilpine Maleate; Egtazic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Magnesium; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Qa-SNARE Proteins; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Superior Colliculi; Synapses; Synaptophysin; Synaptosomal-Associated Protein 25; Tetrodotoxin; Xenopus | 1998 |
Hydrogen peroxide enhances signal-responsive arachidonic acid release from neurons: role of mitogen-activated protein kinase.
Topics: Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Corpus Striatum; Drug Synergism; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Hydrogen Peroxide; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neurons; Phospholipases A; Phospholipases A2; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction | 1998 |
Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia.
Topics: Animals; Cell Count; Chromatography, High Pressure Liquid; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Intraocular Pressure; Ischemia; Male; Memantine; N-Methylaspartate; Ocular Hypertension; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Retinal Vessels; Vitreous Body | 1998 |
Glycine site antagonists and partial agonists inhibit N-methyl-D-aspartate receptor-mediated [3H]arachidonic acid release in cerebellar granule cells.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Arachidonic Acid; Cerebellum; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1998 |
Synaptically evoked dendritic action potentials in rat neocortical pyramidal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Dendrites; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Iontophoresis; Male; Motor Cortex; N-Methylaspartate; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Sodium Channels; Somatosensory Cortex; Tetrodotoxin | 1998 |
Facilitation of responses to AMPA but not kainate by cyclothiazide in primate somatosensory thalamus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Drug Synergism; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Macaca fascicularis; Male; N-Methylaspartate; Thalamic Nuclei | 1998 |
Effect of glutamate receptor agonists on catecholamine secretion in bovine chromaffin cells.
Topics: Adrenal Medulla; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Nicotine; Receptors, Glutamate | 1998 |
Role of vasopressin on excitatory amino acids mediated pressor responses in the periaqueductal gray area.
Topics: Acetylcholine; Animals; Arginine Vasopressin; Blood Pressure; Ganglionic Blockers; Glutamic Acid; Hexamethonium; Losartan; Male; N-Methylaspartate; Periaqueductal Gray; Rats; Rats, Brattleboro | 1998 |
The effect of excitatory aminoacids on GABA release from mediobasal hypothalamus of female rats.
Topics: Animals; Depression, Chemical; Diestrus; Drug Implants; Estradiol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hypothalamus; Interneurons; Kainic Acid; N-Methylaspartate; Nerve Tissue Proteins; Nitric Oxide Synthase; Ovariectomy; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1998 |
Glutamate-stimulated neuropeptide Y mRNA expression in the rat dentate gyrus: a prominent role of metabotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Injections; Injections, Intraperitoneal; Male; N-Methylaspartate; Neuropeptide Y; Neuropeptides; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; RNA, Messenger | 1998 |
Azulenyl nitrone spin traps protect against MPTP neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Azulenes; Brain Chemistry; Dopamine; Free Radicals; Glutamic Acid; Male; Mice; MPTP Poisoning; N-Methylaspartate; Neuroprotective Agents; Nitrogen Oxides; Oxidation-Reduction; Sesquiterpenes; Spin Labels | 1998 |
Changes in GluR4 expression induced by metabotropic receptor activation in radial glia cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Chick Embryo; Cycloleucine; Glutamic Acid; Kainic Acid; Kinetics; N-Methylaspartate; Neuroglia; Polymerase Chain Reaction; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Metabotropic Glutamate; Retina; RNA, Messenger; Transcription, Genetic; Up-Regulation | 1998 |
Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo.
Topics: Animals; Brain; Cerebral Cortex; Corpus Striatum; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Microdialysis; N-Methylaspartate; Neurotransmitter Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Potassium | 1998 |
Characterization of neuroprotection from excitotoxicity by moderate and profound hypothermia in cultured cortical neurons unmasks a temperature-insensitive component of glutamate neurotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Cold Temperature; Cycloleucine; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Fluorescent Dyes; Glutamic Acid; Humans; Hypothermia, Induced; Kainic Acid; Mice; N-Methylaspartate; Neuroglia; Neurons; Neurotoxins; Synapses | 1998 |
Selective modulation of GABAA receptors by aluminum.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aluminum; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; N-Methylaspartate; Neurons, Afferent; Olfactory Bulb; Patch-Clamp Techniques; Rats; Receptors, GABA-A; Receptors, Glutamate; Smell | 1998 |
Low-affinity kainate receptors and long-lasting depression of NMDA-receptor-mediated currents in rat superficial dorsal horn.
Topics: Action Potentials; Animals; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Glutamic Acid; Indoles; Ion Channel Gating; Kainic Acid; Male; N-Methylaspartate; Neurons, Afferent; Neuroprotective Agents; Oximes; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Nerve Roots; Synaptic Transmission | 1998 |
Brain-derived neurotrophic factor modulates hippocampal synaptic transmission by increasing N-methyl-D-aspartic acid receptor activity.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Dizocilpine Maleate; Glutamic Acid; Hippocampus; N-Methylaspartate; Nerve Growth Factors; Neurotrophin 3; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1998 |
Neurotoxic effects of feline immunodeficiency virus, FIV-PPR.
Topics: Acquired Immunodeficiency Syndrome; Animals; Baculoviridae; Brain Chemistry; Calcium; Calcium Signaling; Cats; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Encephalitis; Excitatory Amino Acid Agonists; Feline Acquired Immunodeficiency Syndrome; Female; Gene Products, env; Glutamic Acid; Immunodeficiency Virus, Feline; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Pregnancy; Receptors, N-Methyl-D-Aspartate | 1998 |
A comparison of the effects of clonidine and CNQX infusion into the locus coeruleus and the amygdala on naloxone-precipitated opiate withdrawal in the rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Agonists; Amygdala; Animals; Clonidine; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutamine; Locus Coeruleus; Male; Morphine Dependence; N-Methylaspartate; Naloxone; Narcotic Antagonists; Norepinephrine; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1998 |
Gene transfer of calbindin D28k cDNA via herpes simplex virus amplicon vector decreases cytoplasmic calcium ion response and enhances neuronal survival following glutamatergic challenge but not following cyanide.
Topics: Animals; Calbindin 1; Calbindins; Calcium; Cell Survival; Cells, Cultured; Cytoplasm; DNA, Complementary; Fluorometry; Gene Transfer Techniques; Genetic Vectors; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Plasmids; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G; Simplexvirus; Sodium Cyanide | 1998 |
Substance P post-synaptically potentiates glutamate-induced currents in dorsal vagal neurons.
Topics: Animals; Drug Synergism; Electric Conductivity; Female; Glutamic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Synapses; Vagus Nerve | 1998 |
Multiple sites of action of neomycin, Mg2+ and spermine on the NMDA receptors of rat hippocampal CA1 pyramidal neurones.
Topics: Animals; Binding Sites; Calcium; Cell Line; Cells, Cultured; Evoked Potentials; Glutamic Acid; Glycine; Hippocampus; Humans; Magnesium; N-Methylaspartate; Neomycin; Pyramidal Cells; Rats; Receptors, N-Methyl-D-Aspartate; Spermine; Transfection | 1998 |
Stimulation of Na+-K+-2Cl- cotransporter in neuronal cells by excitatory neurotransmitter glutamate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Bumetanide; Carrier Proteins; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agents; Gene Expression Regulation; Glutamic Acid; Humans; Kinetics; N-Methylaspartate; Neuroblastoma; Neurons; Potassium; Receptors, Glutamate; Sodium-Potassium-Chloride Symporters; Tumor Cells, Cultured | 1998 |
Evidence that excitatory amino acid receptors within the temporomandibular joint region are involved in the reflex activation of the jaw muscles.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Brain Stem; Dose-Response Relationship, Drug; Electromyography; Evans Blue; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Jaw; Kainic Acid; Lidocaine; Male; Masseter Muscle; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Reflex; Temporomandibular Joint; Trigeminal Nerve | 1998 |
Riluzole, a glutamate release inhibitor, and motor behavior.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Behavior, Animal; Benzazepines; Benzodiazepines; Catalepsy; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Locomotion; Male; Motor Activity; N-Methylaspartate; Neuropsychological Tests; Postural Balance; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Riluzole; Smell | 1998 |
Antagonists for group I mGluRs attenuate excitotoxic neuronal death in cortical cultures.
Topics: Animals; Astrocytes; Benzoates; Cell Death; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Indans; Mice; N-Methylaspartate; Neurons; Neurotransmitter Agents; Protein Binding; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1998 |
Evidence for functional native NMDA receptors activated by glycine or D-serine alone in the absence of glutamatergic coagonist.
Topics: Animals; Cerebral Cortex; Cholecystokinin; Dose-Response Relationship, Drug; Drug Synergism; Glutamic Acid; Glycine; Male; N-Methylaspartate; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Somatostatin; Stereoisomerism; Synaptosomes | 1998 |
Dihydrokainate-sensitive neuronal glutamate transport is required for protection of rat cortical neurons in culture against synaptically released glutamate.
Topics: Animals; Biological Transport; Calcium; Calcium Radioisotopes; Cell Survival; Cells, Cultured; Cerebral Cortex; Dicarboxylic Acids; Extracellular Space; Fetus; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Tetrodotoxin | 1998 |
Chronic hyperammonemia impairs the glutamate-nitric oxide-cyclic GMP pathway in cerebellar neurons in culture and in the rat in vivo.
Topics: Ammonia; Animals; Cell Death; Cells, Cultured; Cerebellum; Cyclic GMP; Dialysis Solutions; Dose-Response Relationship, Drug; Extracellular Space; Glutamic Acid; Male; Microdialysis; N-Methylaspartate; Neurons; Nitric Oxide; Perfusion; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Time Factors | 1998 |
Glia modulate NMDA-mediated signaling in primary cultures of cerebellar granule cells.
Topics: Animals; Arachidonic Acid; Astrocytes; Calcium; Cells, Cultured; Cerebellum; Coculture Techniques; Excitatory Amino Acid Agonists; Glutamic Acid; Intracellular Membranes; N-Methylaspartate; Neuroglia; Neurons; Neurotoxins; Osmolar Concentration; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction | 1998 |
Mechanism of the pathogenesis of glutamate neurotoxicity in retinal ischemia.
Topics: Animals; Cats; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Intraocular Pressure; Ischemia; Male; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Retina; Retinal Vessels | 1998 |
Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: involvement of glutamate-induced nitric oxide in motor neuron toxicity and nonmotor neuron protection.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Death; Cell Survival; Cells, Cultured; Cyclic GMP; Dicarboxylic Acids; Embryo, Mammalian; Glutamic Acid; Models, Neurological; Motor Neurons; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Nitric Oxide; Nitric Oxide Donors; Pyrrolidines; Rats; Rats, Wistar; Spinal Cord | 1998 |
Supraoptic oxytocin and vasopressin neurones show differential sensitivity to the neurosteroid pregnenolone sulphate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Excitatory Amino Acid Agonists; Female; Glutamic Acid; N-Methylaspartate; Neurons; Oxytocin; Pregnenolone; Rats; Rats, Wistar; Supraoptic Nucleus; Vasopressins | 1998 |
Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity.
Topics: Animals; Biological Transport; Calcium; Cells, Cultured; Cerebral Cortex; Drug Resistance; Drug Synergism; Excitatory Amino Acid Agonists; Glutamic Acid; Intracellular Membranes; Mice; N-Methylaspartate; Neurons; Neurotoxins; Osmolar Concentration; Sodium; Time Factors | 1998 |
GABA(A) receptor modulates the activity of inner hair cell afferents in guinea pig cochlea.
Topics: Acetylcholine; Action Potentials; Afferent Pathways; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Auditory Pathways; Baclofen; Bicuculline; Cochlea; Electrophysiology; gamma-Aminobutyric Acid; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory, Inner; Iontophoresis; Muscimol; N-Methylaspartate; Receptors, GABA-A | 1998 |
Reduced mitochondrial manganese-superoxide dismutase activity exacerbates glutamate toxicity in cultured mouse cortical neurons.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Glutamic Acid; Homozygote; Kainic Acid; Mice; Mice, Knockout; Mitochondria; N-Methylaspartate; Neurons; Oxidation-Reduction; Quisqualic Acid; Superoxide Dismutase | 1998 |
Conformational changes of the smooth endoplasmic reticulum are facilitated by L-glutamate and its receptors in rat Purkinje cells.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apnea; Bradycardia; Calcium Signaling; Cycloleucine; Dendrites; Endoplasmic Reticulum, Smooth; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia, Brain; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Nerve Tissue Proteins; Neuroprotective Agents; Purkinje Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Respiration | 1998 |
Nicotine administration stimulates the in vivo N-methyl-D-aspartate receptor/nitric oxide/cyclic GMP pathway in rat hippocampus through glutamate release.
Topics: Amino Acids; Animals; Cyclic GMP; Ganglionic Stimulants; Glutamic Acid; Guanylate Cyclase; Hippocampus; Injections, Intraperitoneal; Male; N-Methylaspartate; Nicotine; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
NMDA induced glutamate release from the suprachiasmatic nucleus: an in vitro study in the rat.
Topics: Animals; Circadian Rhythm; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Eye Enucleation; Glutamic Acid; In Vitro Techniques; Magnesium; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Suprachiasmatic Nucleus; Tetrodotoxin; Time Factors | 1998 |
Carnosine modulates zinc and copper effects on amino acid receptors and synaptic transmission.
Topics: Action Potentials; Animals; Brain Chemistry; Carnosine; Cells, Cultured; Copper; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; N-Methylaspartate; Neurons; Olfactory Bulb; Patch-Clamp Techniques; Rats; Receptors, Amino Acid; Receptors, GABA; Receptors, Glutamate; Receptors, Glycine; Synaptic Transmission; Zinc | 1998 |
Assessing the roles of glutamatergic and cholinergic synaptic drive in the control of fictive swimming frequency in young Xenopus tadpoles.
Topics: Animals; Cholinergic Fibers; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Kynurenic Acid; Larva; N-Methylaspartate; Neural Inhibition; Quinoxalines; Receptors, Nicotinic; Swimming; Synapses; Xenopus | 1998 |
Glutamatergic control of the expression of the proenkephalin gene in rat frontoparietal cortical slice cultures.
Topics: Animals; Animals, Newborn; Enkephalins; Frontal Lobe; Gene Expression Regulation, Developmental; Glutamic Acid; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; N-Methylaspartate; Parietal Lobe; Protein Precursors; Rats; Rats, Wistar | 1998 |
Taurine, glutamate and GABA modulate the outgrowth from goldfish retinal explants and its concentrations are affected by the crush of the optic nerve.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Culture Techniques; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Goldfish; N-Methylaspartate; Neurites; Optic Nerve; Retina; Taurine | 1998 |
Effects of chronic lead exposure on glutamate release and uptake in cerebellar cells of rat pups.
Topics: Animals; Cerebellum; Cytoplasmic Granules; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Lead; Male; N-Methylaspartate; Neuroglia; Penicillamine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Sodium-Potassium-Exchanging ATPase | 1998 |
Evidence that brain-derived neurotrophic factor neuroprotection is linked to its ability to reverse the NMDA-induced inactivation of protein kinase C in cortical neurons.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium; Cerebral Cortex; Electrophysiology; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Membrane Potentials; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Phosphorylation; Pregnancy; Protein Kinase C; Proteins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Staurosporine | 1999 |
Ethambutol is toxic to retinal ganglion cells via an excitotoxic pathway.
Topics: Animals; Antitubercular Agents; Calcium; Carbocyanines; Cell Survival; Dose-Response Relationship, Drug; Ethambutol; Ethylenediamines; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glutamic Acid; Memantine; Membrane Potentials; Mitochondria; N-Methylaspartate; Rats; Retinal Ganglion Cells; Tetrazolium Salts; Thiazoles | 1999 |
Coexistence of glutamate and acetylcholine in the developing motoneurons.
Topics: Acetylcholine; Animals; Cells, Cultured; Choline O-Acetyltransferase; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Growth Cones; Membrane Potentials; Motor Neurons; N-Methylaspartate; Nervous System; Patch-Clamp Techniques; Quinoxalines; Receptors, Glutamate; Synapses; Xenopus laevis | 1998 |
Glutamatergic induction of CREB phosphorylation and Fos expression in primary cultures of the suprachiasmatic hypothalamus in vitro is mediated by co-ordinate activity of NMDA and non-NMDA receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cricetinae; Cyclic AMP Response Element-Binding Protein; Dizocilpine Maleate; Gene Expression; Genes, fos; Glutamic Acid; Kainic Acid; Male; Mesocricetus; N-Methylaspartate; Phosphorylation; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Suprachiasmatic Nucleus | 1999 |
Glutamate toxicity in the lung and neuronal cells: prevention or attenuation by VIP and PACAP.
Topics: Animals; Brain; Cell Death; Cell Survival; Cells, Cultured; Fetus; Gene Expression Regulation; Glutamic Acid; Lung; N-Methylaspartate; Neuroglia; Neurons; Neuropeptides; Neuroprotective Agents; PC12 Cells; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Vasoactive Intestinal Peptide | 1998 |
Pharmacological activation and modulation of the central pattern generator for locomotion in the cat.
Topics: 5-Hydroxytryptophan; Animals; Cats; Clonidine; Denervation; Dopamine Agents; Electromyography; Excitatory Amino Acid Agonists; Glutamic Acid; Levodopa; Locomotion; Methoxamine; Motor Neurons; Muscle, Skeletal; N-Methylaspartate; Norepinephrine; Periodicity; Reflex; Serotonin; Spinal Cord; Sympatholytics; Sympathomimetics; Synaptic Transmission | 1998 |
Excitotoxic death of a subset of embryonic rat motor neurons in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Calcium Channels, L-Type; Cell Culture Techniques; Cell Death; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glutamine; Glycine; Kainic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Nerve Tissue Proteins; Neurotoxins; Potassium; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Effects of competitive NMDA receptor antagonists on excitatory amino acid-evoked currents in mouse spinal cord neurones.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding, Competitive; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Excitatory amino acid responses in relay neurons of the rat lateral geniculate nucleus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antihypertensive Agents; Benzothiadiazines; Concanavalin A; Dipeptides; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Geniculate Bodies; Glutamic Acid; Glycine; Ionophores; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neuroprotective Agents; Nystatin; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1999 |
mGluR7-like metabotropic glutamate receptors inhibit NMDA-mediated excitotoxicity in cultured mouse cerebellar granule neurons.
Topics: Animals; Calcium Channels; Cell Death; Cells, Cultured; Cerebellum; Cyclic GMP; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Mice; Microtubule-Associated Proteins; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Patch-Clamp Techniques; Phosphoserine; Propionates; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Glutamate-, kainate- and NMDA-evoked membrane currents in identified glial cells in rat spinal cord slice.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Astrocytes; Cell Membrane; Electric Conductivity; Excitatory Amino Acid Antagonists; Glutamic Acid; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neuroglia; Oligodendroglia; Patch-Clamp Techniques; Rats; Receptors, AMPA; Receptors, Kainic Acid; Spinal Cord | 1998 |
Nitric oxide (NO) release by glutamate and NMDA in the dorsal horn of the spinal cord: an in vivo electrochemical approach in the rat.
Topics: Animals; Dizocilpine Maleate; Electrochemistry; Excitatory Amino Acid Antagonists; Glutamic Acid; Ketamine; Male; N-Methylaspartate; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
NS-257, a novel competitive AMPA receptor antagonist, interacts with kainate and NMDA receptors.
Topics: Animals; Antihypertensive Agents; Benzothiadiazines; Concanavalin A; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Indoles; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Microinjections; N-Methylaspartate; Oocytes; Patch-Clamp Techniques; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Complementary; RNA, Messenger; Sulfonamides; Xenopus | 1999 |
Phrenic nerve responses to chemical stimulation of the subregions of ventral medullary respiratory neuronal group in the rat.
Topics: Animals; Carotid Body; Chemoreceptor Cells; Electrophysiology; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Medulla Oblongata; N-Methylaspartate; Neurons; Phrenic Nerve; Rats; Rats, Wistar; Reflex; Respiration; Stimulation, Chemical | 1999 |
Multiple types of spontaneous excitatory synaptic currents in salamander retinal ganglion cells.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ambystoma; Animals; Convulsants; Darkness; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Kinetics; Larva; N-Methylaspartate; Patch-Clamp Techniques; Photic Stimulation; Picrotoxin; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Strychnine; Synapses; Synaptic Vesicles | 1999 |
Activation of excitatory amino acid receptors in bovine dental pulp evokes the release of iCGRP.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Cattle; Dental Pulp; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurogenic Inflammation; Neurons, Afferent; Nociceptors; Radioimmunoassay; Receptors, Glutamate; Statistics, Nonparametric | 1999 |
Nitric oxide synthase inhibitor decreases NMDA-induced elevations of extracellular glutamate and intracellular Ca2+ levels via a cGMP-independent mechanism in cerebellar granule neurons.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; Cyclic GMP; Dibutyryl Cyclic GMP; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; N-Methylaspartate; Neurons; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley | 1999 |
The effects of excitatory amino acids on isolated gut segments of the rat.
Topics: Animals; Aspartic Acid; Cycloleucine; Digestive System; Digestive System Physiological Phenomena; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Female; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth; N-Methylaspartate; Neuroprotective Agents; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Resistance of gonadotropin-releasing hormone neurons to glutamatergic neurotoxicity.
Topics: Animals; Brain Chemistry; Cricetinae; Excitatory Amino Acid Agonists; Gene Expression; Glutamic Acid; Gonadotropin-Releasing Hormone; In Situ Hybridization; Kainic Acid; Male; N-Methylaspartate; Neurons; Neurotoxins; Phodopus; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1998 |
Analyses of taste nerve responses with special reference to possible receptor mechanisms of umami taste in the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chorda Tympani Nerve; Electrophysiology; Excitatory Amino Acid Agonists; Glutamic Acid; Inosine Monophosphate; Kainic Acid; Male; N-Methylaspartate; Neurons, Afferent; Potassium; Propionates; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Taste | 1999 |
Cardiovascular responses to microinjections of excitatory amino acids into the area postrema of the rat.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Intravenous; Animals; Blood Pressure; Bradycardia; Cerebral Ventricles; Cycloleucine; Decerebrate State; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Male; Microinjections; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Wistar; Tachycardia; Urethane | 1999 |
[NO donors transform neuronal response to glutamate].
Topics: Animals; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Helix, Snails; In Vitro Techniques; Microelectrodes; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Receptors, N-Methyl-D-Aspartate; Sodium Nitrite | 1998 |
N-methyl-D-aspartate (NMDA)-mediated corticotropin-releasing factor (CRF) release in cultured rat amygdala neurons.
Topics: Amygdala; Animals; Cells, Cultured; Corticotropin-Releasing Hormone; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Magnesium; N-Methylaspartate; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley | 1999 |
Effects of retinoic acid on rat forebrain cells derived from embryonic and perinatal rats.
Topics: Animals; Extracellular Space; Glutamic Acid; Immunohistochemistry; Ion Channel Gating; N-Methylaspartate; Prosencephalon; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tretinoin | 1998 |
Dopamine and glutamate neurotoxicity in cultured chick telencephali cells: effects of NMDA antagonists, antioxidants and MAO inhibitors.
Topics: Animals; Antioxidants; Cell Death; Cells, Cultured; Chick Embryo; Dopamine; Drug Interactions; Glutamic Acid; Lipid Peroxidation; Melanins; Monoamine Oxidase; Monoamine Oxidase Inhibitors; N-Methylaspartate; Neurons; Telencephalon | 1999 |
Properties of NMDA receptors in rat spinal cord motoneurons.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Ion Channel Gating; Kainic Acid; Kynurenic Acid; Magnesium; Male; Motor Neurons; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Ionotropic glutamate receptors in isolated horizontal cells of the rabbit retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Ion Channel Gating; Kainic Acid; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, Kainic Acid; Retina | 1999 |
Excitatory amino acids and synaptic transmission in embryonic rat brainstem motoneurons in organotypic culture.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Stem; Coculture Techniques; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Organ Culture Techniques; Rats; Rats, Wistar; Synaptic Transmission | 1999 |
Vagally-regulated gastric motor activity: evidence for kainate and NMDA receptor mediation.
Topics: Animals; Atropine; Blood Pressure; Brain Stem; Bronchodilator Agents; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gastrointestinal Motility; Glutamic Acid; Kainic Acid; Male; Microinjections; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stomach; Vagus Nerve | 1999 |
Involvement of sigma receptors in the modulation of the glutamatergic/NMDA neurotransmission in the dopaminergic systems.
Topics: Analgesics, Opioid; Animals; Caudate Nucleus; Cinnamates; Cyclopropanes; Dopamine; Electrophysiology; Excitatory Amino Acids; Glutamic Acid; Guanidines; Kainic Acid; Male; N-Methylaspartate; Neurons; Nucleus Accumbens; Pentazocine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, sigma; Sigma-1 Receptor; Spiro Compounds; Substantia Nigra; Synaptic Transmission; Thiazoles; Ventral Tegmental Area | 1999 |
NMDA receptor-mediated K+ efflux and neuronal apoptosis.
Topics: Animals; Apoptosis; Calcium; Calcium Channels; Cells, Cultured; Cerebral Cortex; Culture Techniques; Glutamic Acid; Ion Channel Gating; Ion Transport; Membrane Potentials; Mice; N-Methylaspartate; Neocortex; Neurons; Patch-Clamp Techniques; Potassium; Receptors, N-Methyl-D-Aspartate; Sodium | 1999 |
Cytosolic Ca2+ changes during in vitro ischemia in rat hippocampal slices: major roles for glutamate and Na+-dependent Ca2+ release from mitochondria.
Topics: Animals; Calcium; Cytosol; Dizocilpine Maleate; Glutamic Acid; Hippocampus; In Vitro Techniques; Ischemic Attack, Transient; Kinetics; Lidocaine; Male; Mitochondria; N-Methylaspartate; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Calcium Exchanger; Time Factors | 1999 |
Mapping glutamatergic drive in the vertebrate retina with a channel-permeant organic cation.
Topics: Agmatine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Artifacts; Biological Transport; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Immunohistochemistry; In Vitro Techniques; Kainic Acid; Male; Models, Biological; Models, Molecular; N-Methylaspartate; Neurons; Rabbits; Retina; Retinal Ganglion Cells | 1999 |
NMDA receptor-mediated calcium influx in cerebral cortical synaptosomes of the hypoxic guinea pig fetus.
Topics: Animals; Calcium; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Fetal Hypoxia; Glutamic Acid; Glycine; Guinea Pigs; N-Methylaspartate; Potassium Chloride; Pregnancy; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Thapsigargin | 1999 |
Perinatal changes in hypothalamic N-methyl-D-aspartate receptors and their relationship to gonadotropin-releasing hormone neurons.
Topics: Animals; Animals, Newborn; Female; Gene Expression; Glutamic Acid; Gonadotropin-Releasing Hormone; Hypothalamus; Hypothalamus, Anterior; Male; N-Methylaspartate; Neurons; Pregnancy; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1999 |
Age-dependent differences in glutamate-induced phosphorylation systems in rat hippocampal slices.
Topics: Aging; Animals; Brain Chemistry; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin-Binding Proteins; Casein Kinase II; Cyclic AMP-Dependent Protein Kinases; Dynamins; Excitatory Amino Acid Agonists; Glutamic Acid; GTP Phosphohydrolases; Hippocampus; Intramolecular Oxidoreductases; Lipocalins; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Nerve Tissue Proteins; Neurogranin; Organ Culture Techniques; Perchlorates; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Signal Transduction; Solubility; Subcellular Fractions; tau Proteins | 1999 |
The 5-HT2A receptor antagonist M100907 is more effective in counteracting NMDA antagonist- than dopamine agonist-induced hyperactivity in mice.
Topics: Amphetamine; Animals; Dizocilpine Maleate; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fluorobenzenes; Glutamic Acid; Haloperidol; Hyperkinesis; Male; Mice; Mice, Inbred Strains; Motor Activity; N-Methylaspartate; Piperazines; Piperidines; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin Antagonists | 1999 |
Protection by eliprodil against excitotoxicity in cultured rat retinal ganglion cells.
Topics: Animals; Cell Death; Cells, Cultured; Drug Combinations; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Male; N-Methylaspartate; Neuroprotective Agents; Piperidines; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells | 1999 |
Activation of NMDA receptors protects against glutamate neurotoxicity in the retina: evidence for the involvement of neurotrophins.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Growth Factors; Neuroprotective Agents; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptors, N-Methyl-D-Aspartate; Receptors, Nerve Growth Factor; Retina | 1999 |
Excitatory but not inhibitory synaptic transmission is reduced in lethargic (Cacnb4(lh)) and tottering (Cacna1atg) mouse thalami.
Topics: Animals; Calcium Channels; Calcium Channels, N-Type; Calcium Channels, P-Type; Calcium Channels, Q-Type; Epilepsy, Absence; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Homozygote; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mutation; N-Methylaspartate; Neural Inhibition; Synaptic Transmission; Thalamus | 1999 |
AMPA/kainate-related mechanisms contribute to convulsant and proconvulsant effects of 3-nitropropionic acid.
Topics: Animals; Anticonvulsants; Behavior, Animal; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Intraventricular; Male; Mice; Mitochondria; N-Methylaspartate; Nitro Compounds; Propionates; Quinoxalines; Receptors, AMPA | 1999 |
Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated.
Topics: Action Potentials; Animals; Calcium; Dendrites; Glutamic Acid; Hippocampus; In Vitro Techniques; Microscopy, Confocal; N-Methylaspartate; Neuronal Plasticity; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Synapses | 1999 |
(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo.
Topics: Animals; Anticonvulsants; Brain; Cell Line; Cell Membrane; Colforsin; Corpus Striatum; Cyclic AMP; Electroshock; Glutamic Acid; Glycine; Humans; Kinetics; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Neuroprotective Agents; Phosphatidylinositols; Protein Isoforms; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Recombinant Proteins; Second Messenger Systems; Seizures; Structure-Activity Relationship | 1999 |
Contrasting calcium dependencies of SAPK and ERK activations by glutamate in cultured striatal neurons.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Egtazic Acid; Embryo, Mammalian; Enzyme Activation; Glutamic Acid; Kinetics; N-Methylaspartate; Neurons; Phosphorylation; Proto-Oncogene Proteins c-jun; Rats | 1999 |
Calcium neurotoxicity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcimycin; Calcium; Cell Survival; Dizocilpine Maleate; Glutamic Acid; N-Methylaspartate; Neurons; Neurotoxins | 1999 |
Chronic exposure to aluminium impairs the glutamate-nitric oxide-cyclic GMP pathway in the rat in vivo.
Topics: Aluminum; Animals; Calmodulin; Cyclic GMP; Enzyme Activation; Glutamic Acid; Guanylate Cyclase; Male; N-Methylaspartate; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; S-Nitroso-N-Acetylpenicillamine; Tissue Distribution | 1999 |
Activation of NMDA receptors in the suprachiasmatic nucleus produces light-like phase shifts of the circadian clock in vivo.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Brain Chemistry; Circadian Rhythm; Cricetinae; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Lighting; Male; Mesocricetus; Microinjections; Motor Activity; N-Methylaspartate; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Suprachiasmatic Nucleus; Synaptic Transmission | 1999 |
Intra-striatal phencyclidine inhibits N-methyl-D-aspartic acid-stimulated increase in glutamate levels of freely moving rats.
Topics: Animals; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1999 |
Active NMDA glutamate receptors are expressed by mammalian osteoclasts.
Topics: Animals; Bone Remodeling; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Agonists; Glutamic Acid; Kinetics; Membrane Potentials; N-Methylaspartate; Osteoclasts; Patch-Clamp Techniques; Rabbits; Receptors, N-Methyl-D-Aspartate | 1999 |
Anticonvulsant properties of linalool in glutamate-related seizure models.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Glutamic Acid; Kindling, Neurologic; Male; Monoterpenes; N-Methylaspartate; Pentylenetetrazole; Phenobarbital; Quinolinic Acid; Radioligand Assay; Rats; Rats, Wistar; Seizures; Terpenes | 1999 |
Isolation of rat sacral dorsal commissural neurons.
Topics: Animals; Cell Separation; Diazepam; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Microscopy, Phase-Contrast; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1998 |
Enhancement of glutamate release uncovers spillover-mediated transmission by N-methyl-D-aspartate receptors in the rat hippocampus.
Topics: 4-Aminopyridine; Animals; Calcium; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Kinetics; N-Methylaspartate; Osmolar Concentration; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1999 |
N-methyl-D-aspartate receptor-mediated modulation of monoaminergic metabolites and amino acids in the chick forebrain: an in vivo microdialysis and electrophysiology study.
Topics: Amino Acids; Animals; Biogenic Monoamines; Cerebral Ventricles; Chickens; Electrophysiology; Female; Glutamic Acid; Homovanillic Acid; Hydroxyindoleacetic Acid; Infusions, Parenteral; Male; Membrane Potentials; Microdialysis; N-Methylaspartate; Neurons; Potassium; Prosencephalon; Receptors, N-Methyl-D-Aspartate; Taurine | 1999 |
Modulation of the mesolimbic dopamine system by glutamate: role of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 3,4-Dihydroxyphenylacetic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Binding, Competitive; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Homovanillic Acid; Limbic System; Male; Microdialysis; Motor Activity; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Ventral Tegmental Area | 1999 |
Short-term block of Na+/K+-ATPase in neuro-glial cell cultures of cerebellum induces glutamate dependent damage of granule cells.
Topics: 2-Amino-5-phosphonovalerate; Aniline Compounds; Animals; Binding, Competitive; Calcium; Cells, Cultured; Cerebellum; Energy Metabolism; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Lithium; N-Methylaspartate; Neuroglia; Ouabain; Rats; Rats, Wistar; Rhodamine 123; Sodium-Potassium-Exchanging ATPase; Xanthenes | 1999 |
N-methyl-D-aspartate excitotoxicity: relationships among plasma membrane potential, Na(+)/Ca(2+) exchange, mitochondrial Ca(2+) overload, and cytoplasmic concentrations of Ca(2+), H(+), and K(+).
Topics: Animals; Calcium; Cell Membrane; Cells, Cultured; Cytoplasm; Energy Metabolism; Excitatory Amino Acid Agonists; Gluconates; Glutamic Acid; Hydrogen-Ion Concentration; Meglumine; Membrane Potentials; Mitochondria; N-Methylaspartate; Neurons; Potassium; Protons; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Calcium Exchanger | 1999 |
N-methyl-D-aspartate receptor agonists modulate homocysteine-induced developmental abnormalities.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chick Embryo; Cycloserine; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Homocysteine; N-Methylaspartate; Nervous System; Nervous System Malformations; Receptors, N-Methyl-D-Aspartate; Teratogens | 1999 |
Effects of lesions to the glutamatergic afferents to the nucleus accumbens in the modulation of reactivity to spatial and non-spatial novelty in mice.
Topics: Afferent Pathways; Amygdala; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exploratory Behavior; Glutamic Acid; Hippocampus; Ibotenic Acid; Injections; Limbic System; Mice; Models, Neurological; Motor Activity; N-Methylaspartate; Nucleus Accumbens; Spatial Behavior; Valine | 1999 |
Mediation and modulation by eicosanoids of responses of spinal dorsal horn neurons to glutamate and substance P receptor agonists: results with indomethacin in the rat in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Signaling; Cyclooxygenase Inhibitors; Eicosanoids; Excitatory Amino Acid Agonists; Glutamic Acid; Indomethacin; Iontophoresis; Male; N-Methylaspartate; Neurons, Afferent; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord; Substance P | 1999 |
Glutamate-induced increase of extracellular glutamate through N-methyl-D-aspartate receptors in ethanol withdrawal.
Topics: Animals; Corpus Striatum; Dizocilpine Maleate; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Feedback; Glutamic Acid; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Up-Regulation | 1999 |
Role of glutamate receptors and voltage-dependent calcium channels in glutamate toxicity in energy-compromised cortical neurons.
Topics: Agatoxins; Animals; Calcium Channel Blockers; Calcium Channels; Cell Culture Techniques; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Drug Interactions; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glucose; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neuroprotective Agents; Nifedipine; omega-Conotoxin GVIA; Rats; Rats, Wistar; Receptors, Glutamate; Spider Venoms | 1999 |
Elevated extracellular K(+) concentrations inhibit N-methyl-D-aspartate-induced Ca(2+) influx and excitotoxicity.
Topics: Animals; Biological Transport; Calcium; Cell Membrane; Cells, Cultured; Excitatory Amino Acid Agonists; Glutamic Acid; Mitochondria; N-Methylaspartate; Neurons; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Calcium Exchanger | 1999 |
The effect of glutamate uptake inhibitors on hippocampal evoked potentials in vitro.
Topics: Animals; Asparagine; Dicarboxylic Acids; Evoked Potentials; Female; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Pyrrolidines | 1999 |
Metabotropic glutamate receptors group I are involved in cochlear neurotransmission.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory, Inner; Indans; Methoxyhydroxyphenylglycol; N-Methylaspartate; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1999 |
Pyruvate and lactate protect striatal neurons against N-methyl-D-aspartate-induced neurotoxicity.
Topics: Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Cytosol; Energy Metabolism; Excitatory Amino Acid Agonists; Free Radical Scavengers; Glucose; Glutamic Acid; Glycolysis; Kinetics; Lactic Acid; Mice; Mitochondria; N-Methylaspartate; Neostriatum; Neurons; Neurotoxicity Syndromes; Oxygen Consumption; Pyruvic Acid | 1999 |
Serotonin modulation of calcium transients in cells in the suprachiasmatic nucleus.
Topics: Animals; Calcium; Excitatory Amino Acid Agonists; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Serotonin; Suprachiasmatic Nucleus; Synapses | 1999 |
Endogenous activation of metabotropic glutamate receptors in neocortical development causes neuronal calcium oscillations.
Topics: Animals; Calcium; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Lysine; Mice; Microscopy, Fluorescence; N-Methylaspartate; Neocortex; Neuroglia; Neurons; Neuroprotective Agents; Protein Isoforms; Receptors, Metabotropic Glutamate; Time Factors | 1999 |
Pre-steady-state kinetic investigation of intermediates in the reaction catalyzed by adenosylcobalamin-dependent glutamate mutase.
Topics: Catalysis; Chromatography, High Pressure Liquid; Cobamides; Deoxyadenosines; Glutamic Acid; Intramolecular Transferases; Kinetics; Models, Chemical; N-Methylaspartate; Protein Binding; Recombinant Fusion Proteins; Substrate Specificity | 1999 |
NMDA receptor-mediated control of GABA release from neurointermediate lobes of female and male rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Estradiol; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; N-Methylaspartate; Ovariectomy; Pituitary Gland, Posterior; Potassium; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1999 |
mGluR7-like receptor and GABA(B) receptor activation enhance neurotoxic effects of N-methyl-D-aspartate in cultured mouse striatal GABAergic neurones.
Topics: Animals; Baclofen; Cell Survival; Cells, Cultured; Cerebellum; Corpus Striatum; Dizocilpine Maleate; Drug Synergism; Embryo, Mammalian; Excitatory Amino Acid Agonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Kinetics; Mice; N-Methylaspartate; Neurons; Neurotoxins; Propionates; Receptors, GABA-B; Receptors, Metabotropic Glutamate | 1999 |
Substrate turnover by transporters curtails synaptic glutamate transients.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Benzothiadiazines; Cells, Cultured; Evoked Potentials; Glutamic Acid; Hippocampus; Membrane Potentials; N-Methylaspartate; Neuroglia; Neurons; Oocytes; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission; Xenopus laevis | 1999 |
Ischaemic pre-conditioning in organotypic hippocampal slice cultures is inversely correlated to the induction of the 72 kDa heat shock protein (HSP72).
Topics: Animals; Brain Ischemia; Excitatory Amino Acid Agonists; Glutamic Acid; Heat-Shock Proteins; Hippocampus; HSP72 Heat-Shock Proteins; Ischemic Preconditioning; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1999 |
Autoradiographic study of NMDA-displaceable [3H]glutamate and [3H]MK-801 binding during butorphanol withdrawal in the rat brain.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Butorphanol; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Intraventricular; Male; N-Methylaspartate; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Tritium | 1999 |
N-methyl-D-aspartate receptor binding is altered and seizure potential reduced in pregnant rats.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Convulsants; Dizocilpine Maleate; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Hippocampus; Male; N-Methylaspartate; Pregnancy; Pregnancy, Animal; Radioligand Assay; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Tritium | 1999 |
Regulation of NMDA-stimulated [14C]GABA and [3H]acetylcholine release by striatal glutamate and dopamine receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoates; Carbon Radioisotopes; Corpus Striatum; Cycloleucine; Dopamine Agonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; Male; N-Methylaspartate; Proline; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tritium | 1999 |
Nitric oxide mediates excitotoxic and anoxic damage in rat retinal ganglion cells cocultured with astroglia.
Topics: Animals; Astrocytes; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells | 1999 |
Putative partial agonist 1-aminocyclopropanecarboxylic acid acts concurrently as a glycine-site agonist and a glutamate-site antagonist at N-methyl-D-aspartate receptors.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Binding Sites; Cerebellum; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate | 1999 |
Adenosine-amino acid interactions in the chick brain: a role in passive avoidance learning.
Topics: Adenosine; Animals; Avoidance Learning; Chickens; Corpus Striatum; Excitatory Amino Acid Agonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; N-Methylaspartate; Phenethylamines; Potassium Chloride; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1 | 1999 |
Excitation of dorsal motor vagal neurons evokes non-nicotinic receptor-mediated gastric relaxation.
Topics: Animals; Area Under Curve; Atropine; Dose-Response Relationship, Drug; Gastrointestinal Motility; Glutamic Acid; Hexamethonium; Male; Medulla Oblongata; Microinjections; Motor Neurons; Muscle Relaxation; N-Methylaspartate; Nicotinic Antagonists; Nitric Oxide; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Stomach; Vagus Nerve | 1999 |
Glutamate-stimulated calcium activation of Ras/Erk pathway mediated by nitric oxide.
Topics: Animals; Calcium; Cerebral Cortex; Glutamic Acid; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; ras Proteins; Receptors, Glutamate | 1999 |
Functional characterization of N-methyl-D-aspartic acid-gated channels in bone cells.
Topics: Binding Sites; Bone and Bones; Calcium; Cells, Cultured; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Intracellular Fluid; Ion Channel Gating; Ion Channels; Kinetics; Membrane Potentials; N-Methylaspartate; Osteoblasts; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate | 1999 |
The glutamate receptor antagonist MK801 modulates bone resorption in vitro by a mechanism predominantly involving osteoclast differentiation.
Topics: Actins; Animals; Bone Resorption; Cell Differentiation; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Ligands; Mice; N-Methylaspartate; Osteoclasts; Patch-Clamp Techniques; Rabbits; Rats; Receptors, N-Methyl-D-Aspartate | 1999 |
Characterization of AMPA receptors on isolated amacrine-like cells in carp retina.
Topics: Alternative Splicing; Animals; Antihypertensive Agents; Benzodiazepines; Benzothiadiazines; Cell Separation; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Goldfish; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Phenoxyacetates; Receptors, AMPA; Retina | 1999 |
The ontogeny of glutamate receptors and D-aspartate binding sites in the ovine CNS.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Aspartic Acid; Autoradiography; Binding Sites; Brain; Embryonic and Fetal Development; Fetus; Glutamic Acid; Kainic Acid; N-Methylaspartate; Receptors, Glutamate; Sheep | 1999 |
Locomotor activity and accumbens Fos expression driven by ventral hippocampal stimulation require D1 and D2 receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Benzazepines; Brain Chemistry; Cycloleucine; Dextroamphetamine; Dopamine Agents; Dopamine Antagonists; Excitatory Amino Acid Agonists; Genes, Immediate-Early; Glutamic Acid; Haloperidol; Hippocampus; Kainic Acid; Lidocaine; Locomotion; Male; N-Methylaspartate; Neural Pathways; Neuroprotective Agents; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1999 |
Effects of ciliary neurotrophic factor on excitotoxicity and calcium-ionophore A23187-induced cell death in cultured embryonic striatal neurons.
Topics: Animals; Calcimycin; Cell Death; Cell Survival; Cells, Cultured; Ciliary Neurotrophic Factor; Corpus Striatum; Cycloheximide; Embryo, Mammalian; Glutamic Acid; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley | 1999 |
[The ameliorating effects of a novel NC-1900 on impairments of learning/memory caused by glutamic acid].
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arginine Vasopressin; Avoidance Learning; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Kainic Acid; Learning Disabilities; Male; Memory Disorders; Mice; Mice, Inbred Strains; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oligopeptides; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Resorcinols | 1999 |
Glutamate and GABA activate different receptors and Cl(-) conductances in crab peptide-secretory neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Brachyura; Cells, Cultured; Chloride Channels; Chlorides; Concanavalin A; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Quisqualic Acid; Receptors, AMPA; Receptors, GABA; Receptors, Glutamate | 2000 |
Cholecystokinin (CCK) increases GABA release in the rat anterior nucleus accumbens via CCK(B) receptors located on glutamatergic interneurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cholecystokinin; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Interneurons; Male; Microdialysis; N-Methylaspartate; Nucleus Accumbens; Potassium; Quinoxalines; Rats; Rats, Wistar; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide; Stimulation, Chemical; Tetrodotoxin | 2000 |
N-methyl-D-aspartate receptor blockade enhances neuronal apoptosis induced by serum deprivation.
Topics: Animals; Apoptosis; Cells, Cultured; Cellular Senescence; Cerebral Cortex; Culture Media, Serum-Free; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate | 2000 |
Neurotransmitter interactions in schizophrenia-therapeutic implications.
Topics: Brain; Dopamine; Dopamine Agents; Glutamic Acid; Humans; N-Methylaspartate; Neuroprotective Agents; Receptors, GABA; Schizophrenia; Synaptic Transmission | 1999 |
Participation of NMDA and kainate receptors of paraventricular nucleus in cardiovascular responses to glutamate receptor agonist.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Hemodynamics; Kainic Acid; Male; Microinjections; N-Methylaspartate; Paraventricular Hypothalamic Nucleus; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 2000 |
Intracellular survival pathways against glutamate receptor agonist excitotoxicity in cultured neurons. Intracellular calcium responses.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium; Cells, Cultured; Cerebellum; Excitatory Amino Acid Agonists; Exocytosis; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Potassium; Rats; Receptors, Glutamate | 1999 |
Alterations in calcium-mediated signal transduction after traumatic injury of cortical neurons.
Topics: Animals; Brain Injuries; Calcium; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Neuroglia; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Thapsigargin | 1999 |
NMDA-Receptor-dependent synaptic activation of voltage-dependent calcium channels in basolateral amygdala.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amygdala; Animals; Bicuculline; Calcium; Calcium Channels; Cesium; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; N-Methylaspartate; Patch-Clamp Techniques; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Tetrodotoxin | 2000 |
Transcription factors Oct-1 and C/EBPbeta (CCAAT/enhancer-binding protein-beta) are involved in the glutamate/nitric oxide/cyclic-guanosine 5'-monophosphate-mediated repression of mediated repression of gonadotropin-releasing hormone gene expression.
Topics: Animals; Binding Sites; CCAAT-Enhancer-Binding Proteins; Cell Line; Cyclic GMP; DNA-Binding Proteins; Enhancer Elements, Genetic; Gene Expression Regulation; Glutamic Acid; Gonadotropin-Releasing Hormone; Host Cell Factor C1; Hypothalamus; Mice; N-Methylaspartate; Neurons; Nitric Oxide; Nitroprusside; Nuclear Proteins; Octamer Transcription Factor-1; Rats; Repressor Proteins; Signal Transduction; Transcription Factors | 2000 |
Poly(ADP-ribosyl)ation basally activated by DNA strand breaks reflects glutamate-nitric oxide neurotransmission.
Topics: Animals; Autoradiography; Brain; Cells, Cultured; DNA Damage; Enzyme Activation; Glutamic Acid; Immunohistochemistry; Kidney; Mice; Mice, Knockout; N-Methylaspartate; NAD; Nitric Oxide; Poly (ADP-Ribose) Polymerase-1; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Proteins; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2000 |
Methylmalonic and propionic acids increase the in vitro incorporation of 32P into cytoskeletal proteins from cerebral cortex of young rats through NMDA glutamate receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cerebral Cortex; Cytoskeletal Proteins; Glutamic Acid; In Vitro Techniques; Methylmalonic Acid; N-Methylaspartate; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Propionates; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2000 |
p75-mediated neuroprotection by NGF against glutamate cytotoxicity in cortical cultures.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium; Calcium Channels; Cell Death; Ceramides; Cerebral Cortex; Excitatory Amino Acid Agonists; Fetus; Glutamic Acid; Ionophores; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; N-Methylaspartate; Nerve Growth Factor; Neurons; Neuroprotective Agents; Nitric Oxide Donors; PC12 Cells; Rats; Receptor, Nerve Growth Factor; Receptor, trkA; Receptor, trkB | 2000 |
Effects of dalargin on excitation induced by L-glutamate agonists in the frog vestibular organs.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Dendrites; Electrophysiology; Enkephalin, Leucine-2-Alanine; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons, Afferent; Rana temporaria; Receptors, Opioid; Synapses; Vestibule, Labyrinth | 2000 |
Control of synaptic depression by glutamate transporters.
Topics: Action Potentials; Alanine Transaminase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Anti-Bacterial Agents; Antihypertensive Agents; Aspartic Acid; ATP-Binding Cassette Transporters; Benzothiadiazines; Chick Embryo; Cochlear Nucleus; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neural Inhibition; Neuronal Plasticity; Receptors, AMPA; Synaptic Transmission | 2000 |
Inhibitors of phospholipase C prevent glutamate neurotoxicity in primary cultures of cerebellar neurons.
Topics: Animals; Carbachol; Cells, Cultured; Cerebellum; Estrenes; Glutamic Acid; N-Methylaspartate; Neuroprotective Agents; Phosphodiesterase Inhibitors; Phospholipid Ethers; Pyrrolidinones; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Type C Phospholipases | 2000 |
Marking synaptic activity in dendritic spines with a calpain substrate exhibiting fluorescence resonance energy transfer.
Topics: Amino Acid Sequence; Animals; Biomarkers; Calcium; Calpain; COS Cells; Culture Techniques; Dendrites; Energy Transfer; Fluorescence; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Intracellular Fluid; Long-Term Potentiation; Luminescent Proteins; Microscopy, Fluorescence; Molecular Sequence Data; N-Methylaspartate; Rats; Receptors, Glutamate; Recombinant Fusion Proteins; Spectrin; Spectrometry, Fluorescence; Substrate Specificity; Synaptic Transmission | 2000 |
Potentiation by L-cysteine of N-methyl-D-aspartate receptor: effects on intracellular free Ca2+ in cultured cerebellar granule cells.
Topics: Animals; Calcium; Calcium Radioisotopes; Cell Membrane; Cells, Cultured; Cerebellum; Cysteine; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Zinc | 1999 |
Differing effects of copper,zinc superoxide dismutase overexpression on neurotoxicity elicited by nitric oxide, reactive oxygen species, and excitotoxins.
Topics: Animals; Astrocytes; Cell Death; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Gene Expression Regulation, Enzymologic; Glutamic Acid; Humans; Hydrazines; Kainic Acid; Mice; Mice, Transgenic; N-Methylaspartate; Neurons; Neurotoxins; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Penicillamine; Reactive Oxygen Species; Spermine; Superoxide Dismutase; Tyrosine; Vitamin K | 2000 |
3,4-Methylenedioxymetamphetamine (ecstasy) induces c-fos-like protein and mRNA in rat organotypic dorsal striatal slices.
Topics: Animals; Brain Chemistry; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Excitatory Amino Acid Agonists; Glutamic Acid; Hallucinogens; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Mesencephalon; N-Methyl-3,4-methylenedioxyamphetamine; N-Methylaspartate; Neostriatum; Proto-Oncogene Proteins c-fos; Rats; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 2000 |
NMDA receptor-mediated control of protein synthesis at developing synapses.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cycloheximide; Electrophoresis, Gel, Two-Dimensional; Glutamic Acid; Isoelectric Point; Molecular Weight; N-Methylaspartate; Peptide Elongation Factor 2; Phosphorylation; Precipitin Tests; Protein Biosynthesis; Proteins; Rats; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Superior Colliculi; Synapses; Synaptosomes; Time Factors | 2000 |
Choline release and inhibition of phosphatidylcholine synthesis precede excitotoxic neuronal death but not neurotoxicity induced by serum deprivation.
Topics: Animals; Blood; Cell Death; Cells, Cultured; Cerebellum; Cerebral Cortex; Choline; Cytidine Diphosphate Choline; Glutamic Acid; Hydrolysis; Membrane Lipids; N-Methylaspartate; Necrosis; Neurons; Phosphatidylcholines; Phospholipids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2000 |
NMDA spikes in basal dendrites of cortical pyramidal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cadmium; Calcium; Calcium Channel Blockers; Cerebral Cortex; Computer Simulation; Dendrites; Electrophysiology; Evoked Potentials; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Pyramidal Cells; Rats; Receptors, N-Methyl-D-Aspartate; Synapses; Tetrodotoxin | 2000 |
Behavioural effects of glutamate receptor agonists in morphine-dependent rats.
Topics: Animals; Behavior, Animal; Brain Chemistry; Discrimination, Psychological; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Isosorbide Dinitrate; Kainic Acid; Male; Morphine Dependence; N-Methylaspartate; Naloxone; Narcotic Antagonists; Nitric Oxide Donors; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Involvement of NMDA-receptor in kainate-induced neurotoxicity in cultured fetal retinal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Death; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Retina | 2000 |
Intracellular glutathione levels determine cerebellar granule neuron sensitivity to excitotoxic injury by kainic acid.
Topics: Animals; Cell Survival; Cerebellum; Excitatory Amino Acid Agonists; Fluoresceins; Glutamic Acid; Glutathione; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Radiation-Protective Agents; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2000 |
Effect of intracerebral administration of NMDA and AMPA on dopamine and glutamate release in the ventral pallidum and on motor behavior.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Brain; Dopamine; Excitatory Amino Acid Agonists; Globus Pallidus; Glutamic Acid; Injections; Male; Microdialysis; Motor Activity; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Tegmentum Mesencephali | 2000 |
Caspase-mediated degradation of AMPA receptor subunits: a mechanism for preventing excitotoxic necrosis and ensuring apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Calcium; Caspases; Cell Survival; Cells, Cultured; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Glutamic Acid; Hippocampus; N-Methylaspartate; Necrosis; Neocortex; Nerve Degeneration; Nerve Growth Factors; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synaptosomes | 2000 |
Acute decrease in net glutamate uptake during energy deprivation.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Brain Ischemia; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kinetics; Membrane Potentials; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Organ Culture Techniques; Patch-Clamp Techniques; Pyrrolidines; Quinoxalines; Rats | 2000 |
Nonsaturation of AMPA and NMDA receptors at hippocampal synapses.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding, Competitive; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Iontophoresis; N-Methylaspartate; Patch-Clamp Techniques; Pyramidal Cells; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2000 |
Cyclic GMP-dependent feedback inhibition of AMPA receptors is independent of PKG.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 1; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Feedback; Glutamic Acid; Hippocampus; In Vitro Techniques; N-Methylaspartate; Neural Inhibition; Nitric Oxide Donors; Nitric Oxide Synthase; Patch-Clamp Techniques; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Pyramidal Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2000 |
Regulation of tyrosine hydroxylase activity and phosphorylation at Ser(19) and Ser(40) via activation of glutamate NMDA receptors in rat striatum.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antibody Specificity; Catalytic Domain; Caudate Nucleus; Colforsin; Dihydroxyphenylalanine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Okadaic Acid; Oxidopamine; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Sympatholytics; Tyrosine 3-Monooxygenase | 2000 |
Biophysical properties and responses to glutamate receptor agonists of identified subpopulations of rat geniculate ganglion neurons.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Size; Cells, Cultured; Excitatory Amino Acid Agonists; Female; Geniculate Ganglion; Glutamic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Receptors, Glutamate; Synaptic Transmission; Taste | 2000 |
NOC/oFQ contributes to hypoxic-ischemic impairment of N-methyl-D-aspartate-induced cerebral vasodilation.
Topics: Animals; Animals, Newborn; Blood Gas Analysis; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Hypoxia, Brain; Male; N-Methylaspartate; Nociceptin; Opioid Peptides; Pia Mater; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Swine; Vasodilation | 2000 |
Activity-dependent neuronal control of gap-junctional communication in astrocytes.
Topics: Action Potentials; Animals; Astrocytes; Calcium Signaling; Cell Communication; Cell Count; Cell Membrane Permeability; Cells, Cultured; Connexin 43; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gap Junctions; Glutamic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neurotoxins; Pregnancy; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, GABA-A; Synaptic Transmission; Tetrodotoxin; Time Factors; Up-Regulation | 2000 |
Neurotoxicity of glutamate in chick telencephalon neurons: reduction of toxicity by preincubation with carbachol, but not by the endogenous fatty acid amides anandamide and palmitoylethanolamide.
Topics: Amides; Animals; Arachidonic Acids; Carbachol; Chick Embryo; Dizocilpine Maleate; Drug Antagonism; Endocannabinoids; Ethanolamines; Excitatory Amino Acid Antagonists; Glutamic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neuroprotective Agents; Palmitic Acids; Polyunsaturated Alkamides; Rats; Species Specificity; Telencephalon | 2000 |
Effects of glutamate agonist versus procaine microinjections into the basal forebrain cholinergic cell area upon gamma and theta EEG activity and sleep-wake state.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Arousal; Behavior, Animal; Cholinergic Fibers; Electromyography; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microinjections; N-Methylaspartate; Neurons; Procaine; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Sleep; Theta Rhythm | 2000 |
Physiological activation of presynaptic metabotropic glutamate receptors increases intracellular calcium and glutamate release.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Axons; Brain Stem; Calcium; Chromones; Cycloleucine; Dendrites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fluorometry; Glutamic Acid; Glycine Agents; GTP-Binding Proteins; In Vitro Techniques; Lampreys; Larva; Membrane Potentials; N-Methylaspartate; Neuronal Plasticity; Neuroprotective Agents; Patch-Clamp Techniques; Presynaptic Terminals; Quisqualic Acid; Receptors, Metabotropic Glutamate; Strychnine; Tetrodotoxin | 2000 |
Excitatory amino acid stimulation of the survival of rat cerebellar granule cells in culture is associated with an increase in SMN, the spinal muscular atrophy disease gene product.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebellum; Culture Media; Cyclic AMP Response Element-Binding Protein; Excitatory Amino Acids; Fluorescent Antibody Technique; Glutamic Acid; Humans; Microscopy, Fluorescence; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Potassium; Rats; RNA-Binding Proteins; SMN Complex Proteins; Survival of Motor Neuron 1 Protein | 2000 |
Effects of mild versus deep hypothermia on a cloned human brain glutamate transporter (GLT-1) expressed in Chinese hamster ovary cells.
Topics: Adult; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Biological Transport; Cell Division; Cell Membrane; Cerebral Cortex; CHO Cells; Cloning, Molecular; Cricetinae; Gene Library; Glutamic Acid; Humans; Hypothermia; Kainic Acid; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Quisqualic Acid; Recombinant Proteins; Temperature | 2000 |
Evaluation and comparison of ion permeation and agonist selectivities for N-methyl-d-aspartate receptor channels with different subunit compositions in bilayer lipid membranes based on integrated single-channel currents.
Topics: Animals; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Electrophysiology; Evaluation Studies as Topic; Excitatory Amino Acid Agonists; Glutamic Acid; Lipid Bilayers; N-Methylaspartate; Permeability; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2000 |
Delayed mitochondrial dysfunction in excitotoxic neuron death: cytochrome c release and a secondary increase in superoxide production.
Topics: Animals; Apoptosis; Cytochrome c Group; Electron Transport; Electron Transport Complex III; Electrons; Excitatory Amino Acid Agonists; Free Radical Scavengers; Glutamic Acid; Hippocampus; Humans; Medulloblastoma; Membrane Potentials; Metalloporphyrins; Mitochondria; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Inbred F344; Reactive Oxygen Species; Superoxide Dismutase; Superoxides; Tumor Cells, Cultured | 2000 |
Kindling causes persistent in vivo changes in firing rates and glutamate sensitivity of central piriform cortex neurons in rats.
Topics: Action Potentials; Amygdala; Animals; Excitatory Amino Acid Agonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Kindling, Neurologic; N-Methylaspartate; Neurons; Rats; Rats, Wistar | 2000 |
Theory for the feedback inhibition of fast release of neurotransmitter.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Autoreceptors; Binding Sites; Computer Simulation; Excitatory Amino Acid Agonists; Feedback; Glutamic Acid; Humans; Membrane Potentials; Models, Biological; Muscarine; Muscarinic Antagonists; N-Methylaspartate; Neurotransmitter Agents; Second Messenger Systems | 2000 |
Neuroprotection produced by the NAALADase inhibitor 2-PMPA in rat cerebellar neurons.
Topics: Animals; Carboxypeptidases; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebellum; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamate Carboxypeptidase II; Glutamic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Veratridine | 2000 |
Effect of carnosine on rats under experimental brain ischemia.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Carnosine; Exploratory Behavior; Glutamic Acid; Male; Maze Learning; Monoamine Oxidase; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 2000 |
Glutamate-induced production of nitric oxide in guinea pig vestibular sensory cells.
Topics: Acoustic Maculae; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Fluorescein; Fluorescent Dyes; Glutamic Acid; Guinea Pigs; Hair Cells, Vestibular; Microscopy, Fluorescence; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase | 2000 |
Glufosinate ammonium stimulates nitric oxide production through N-methyl D-aspartate receptors in rat cerebellum.
Topics: Aminobutyrates; Animals; Cerebellum; Glutamic Acid; Herbicides; Kainic Acid; Male; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate | 2000 |
Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death.
Topics: Aminobutyrates; Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Heterozygote; Mice; Mice, Knockout; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Receptors, Metabotropic Glutamate; Stereoisomerism | 2000 |
Glutamate-mediated neuroprotection against N-methyl-D-aspartate toxicity: a role for metabotropic glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cell Death; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Neuroprotective Agents; Oligodeoxyribonucleotides, Antisense; Organ Culture Techniques; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Tetrodotoxin | 2000 |
Synaptic activation of presynaptic kainate receptors on hippocampal mossy fiber synapses.
Topics: Animals; Cells, Cultured; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Mossy Fibers, Hippocampal; N-Methylaspartate; Patch-Clamp Techniques; Potassium; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Synapses; Synaptic Transmission | 2000 |
N-methyl-D-aspartate but not glutamate induces the release of hydroxyl radicals in the neonatal rat: modulation by group I metabotropic glutamate receptors.
Topics: Animals; Animals, Newborn; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hydroxybenzoates; Hydroxyl Radical; Hypoxia-Ischemia, Brain; Ibotenic Acid; Indans; Microdialysis; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols | 2000 |
Bilirubin does not modulate ionotropic glutamate receptors or glutamate transporters.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Bilirubin; Glutamic Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2000 |
The spinal 5-HT system contributes to the generation of fictive locomotion in lamprey.
Topics: Animals; Glutamic Acid; In Vitro Techniques; Lampreys; Locomotion; Motor Activity; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Spinal Cord; Spiperone | 2000 |
Light and glutamate-induced degradation of the circadian oscillating protein BMAL1 during the mammalian clock resetting.
Topics: Animals; Antibodies; ARNTL Transcription Factors; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Circadian Rhythm; Darkness; Dose-Response Relationship, Drug; Glutamic Acid; Immunoblotting; In Vitro Techniques; Light; Male; N-Methylaspartate; Organ Specificity; Photoperiod; Rats; Rats, Wistar; Suprachiasmatic Nucleus; Tetrodotoxin; Transcription Factors | 2000 |
Antihistamine terfenadine potentiates NMDA receptor-mediated calcium influx, oxygen radical formation, and neuronal death.
Topics: Animals; Biological Transport; Calcium; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Chlorpheniramine; Cyclic GMP; Dizocilpine Maleate; Drug Synergism; Glutamic Acid; Histamine; Histamine H1 Antagonists; N-Methylaspartate; Neurons; Piperazines; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Terfenadine; Triprolidine | 2000 |
The alpha7 nicotinic acetylcholine receptor subtype mediates nicotine protection against NMDA excitotoxicity in primary hippocampal cultures through a Ca(2+) dependent mechanism.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Calcium Radioisotopes; Cell Survival; Cells, Cultured; Cytoplasm; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; N-Methylaspartate; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic | 2000 |
NOC/oFQ contributes to age-dependent impairment of NMDA-induced cerebrovasodilation after brain injury.
Topics: Aging; Animals; Animals, Newborn; Arterioles; Blood Pressure; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Excitatory Amino Acids; Female; Glutamic Acid; Male; N-Methylaspartate; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Pia Mater; Receptors, Opioid; Swine; Vasoconstriction; Vasodilation; Wounds, Nonpenetrating | 2000 |
In situ Ca2+ imaging reveals neurotransmitter receptors for glutamate in taste receptor cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cells, Cultured; Dextrans; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Fluorescent Dyes; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Microscopy, Confocal; N-Methylaspartate; Neurotransmitter Agents; Organic Chemicals; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Taste Buds | 2000 |
Subacute nicotine exposure in cultured cerebellar cells increased the release and uptake of glutamate.
Topics: Animals; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Female; Glutamate-Ammonia Ligase; Glutamic Acid; Male; N-Methylaspartate; Nicotine; Rats; Rats, Sprague-Dawley | 2000 |
A quantitative analysis of L-glutamate-regulated Na+ dynamics in mouse cortical astrocytes: implications for cellular bioenergetics.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Astrocytes; Benzothiadiazines; Biological Transport; Carrier Proteins; Cells, Cultured; Cerebral Cortex; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Kainic Acid; Kinetics; Mice; Models, Theoretical; N-Methylaspartate; Sodium; Symporters | 2000 |
Neuroprotective effects of brain-derived neurotrophic factor in eyes with NMDA-induced neuronal death.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Count; Cell Death; Fluorescent Dyes; Glutamic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Stilbamidines; Vitreous Body | 2000 |
Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism.
Topics: Animals; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Fetus; Glutamic Acid; Glycine; Hydrolysis; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phenylacetates; Phosphatidylinositols; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2000 |
NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; ATP-Binding Cassette Transporters; Cell Death; Cells, Cultured; Cerebral Cortex; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Intracellular Fluid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2000 |
Molecular evidence for the involvement of NR2B subunit containing N-methyl-D-aspartate receptors in the development of morphine-induced place preference.
Topics: Animals; Antibodies; Behavior, Animal; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; N-Methylaspartate; Neurons; Prosencephalon; Receptors, N-Methyl-D-Aspartate; Reward; Seizures | 2000 |
Effects of N-methyl-D-aspartate, kainate or veratridine on extracellular concentrations of free D-serine and L-glutamate in rat striatum: an in vivo microdialysis study.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Kainic Acid; Male; Microdialysis; N-Methylaspartate; Perfusion; Rats; Rats, Wistar; Serine; Time Factors; Veratridine | 2000 |
Glutamate-gated calcium fluxes in Arabidopsis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Arabidopsis; Calcium; Egtazic Acid; Excitatory Amino Acid Agonists; Glutamic Acid; Ion Channel Gating; Ion Channels; Lanthanum; N-Methylaspartate | 2000 |
Interferon-alpha inhibits long-term potentiation and unmasks a long-term depression in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Genistein; Glutamic Acid; Hippocampus; Immunologic Factors; In Vitro Techniques; Interferon-alpha; Long-Term Potentiation; N-Methylaspartate; Neural Inhibition; Neuronal Plasticity; Pyramidal Cells; Rats; Receptors, GABA-A; Synapses | 2000 |
mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors.
Topics: Animals; Brain Injuries; Cell Survival; Cells, Cultured; Cerebral Cortex; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Hydrolysis; Male; Maze Learning; Memory; N-Methylaspartate; Neurons; Neuroprotective Agents; Phosphatidylinositols; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2001 |
Impairment of the Ca2+-permeable AMPA/kainate receptors by lead exposure in organotypic rat hippocampal slice cultures.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Animals, Suckling; Biological Transport; Calcium; Cobalt; Glutamic Acid; Hippocampus; Lead; N-Methylaspartate; Organ Culture Techniques; Permeability; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid | 2000 |
Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons.
Topics: Animals; Dopamine; Dopamine Agonists; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Memory; N-Methylaspartate; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D5; Synaptic Transmission | 2001 |
Altered striatal amino acid neurotransmitter release monitored using microdialysis in R6/1 Huntington transgenic mice.
Topics: Amino Acids; Animals; Aspartic Acid; Corpus Striatum; gamma-Aminobutyric Acid; Glutamic Acid; Huntington Disease; Mice; Mice, Transgenic; Microdialysis; N-Methylaspartate; Neurotransmitter Agents; Potassium Chloride | 2001 |
Mechanisms of [2,3-butanedione bis(N4-dimethylthiosemicarbazone)]zinc (Zn-ATSM2)-induced protection of cultured hippocampal neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity.
Topics: Animals; Calcium; Cells, Cultured; Embryo, Mammalian; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Organometallic Compounds; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Thiosemicarbazones | 2000 |
Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons.
Topics: Animals; Calcitriol; Calcium Channels, L-Type; Cell Count; Cell Survival; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Down-Regulation; Glutamic Acid; Hippocampus; N-Methylaspartate; Neuroglia; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, Calcitriol; RNA, Messenger | 2001 |
Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice.
Topics: Animals; Brain; Cerebrovascular Circulation; Crosses, Genetic; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Functional Laterality; Glutamic Acid; Heterozygote; Homozygote; Ischemic Attack, Transient; Isoenzymes; Kidney; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Cerebral Artery; N-Methylaspartate; Neurotoxins; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic | 2001 |
Cortical and striatal neuronal cultures of the same embryonic origin show intrinsic differences in glutamate receptor expression and vulnerability to excitotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Cerebral Cortex; Corpus Striatum; Gene Expression Regulation; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neurotoxins; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Transcription, Genetic | 2001 |
Cross-talk between excitatory and inhibitory amino acids in the regulation of growth hormone secretion in neonatal rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Baclofen; Bicuculline; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Growth Hormone; Growth Hormone-Releasing Hormone; Male; Muscimol; N-Methylaspartate; Neurosecretory Systems; Quinoxalines; Rats; Rats, Wistar; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Sex Characteristics | 2001 |
Dendritic glutamate-induced bursting in prefrontal pyramidal cells: role of NMDA and non-NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dendrites; Glutamic Acid; Male; N-Methylaspartate; Prefrontal Cortex; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1999 |
N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influx.
Topics: 2,4-Dinitrophenol; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Cyclosporine; Dibucaine; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluoresceins; Fluorescent Dyes; Glutamic Acid; Heterocyclic Compounds, 3-Ring; Imidazoles; Kainic Acid; Mitochondria; Motor Neuron Disease; Motor Neurons; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Neurotoxins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Rhodamines; Spinal Cord; Superoxide Dismutase; Uncoupling Agents | 2001 |
Tissue plasminogen activator protects hippocampal neurons from oxygen-glucose deprivation injury.
Topics: Animals; Antibodies; Apoptosis; Cell Hypoxia; Cells, Cultured; Culture Media, Conditioned; Excitatory Amino Acid Agonists; Fibrinolysin; Glucose; Glutamic Acid; Hippocampus; Humans; Hydrogen Peroxide; Kainic Acid; Microglia; Microscopy, Fluorescence; N-Methylaspartate; Neuroprotective Agents; Nitric Oxide Donors; Oxidants; Oxygen; Penicillamine; Plasminogen Activator Inhibitor 1; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tissue Plasminogen Activator | 2001 |
Anoxic depolarization mediates acute damage independent of glutamate in neocortical brain slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain Ischemia; Cortical Spreading Depression; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia; Kynurenic Acid; Male; N-Methylaspartate; Neocortex; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 2001 |
Effect of excitatory amino acids on serum TSH and thyroid hormone levels in freely moving rats.
Topics: Animals; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Thyrotropin; Thyroxine; Triiodothyronine | 2000 |
Characterization of the glutamatergic system for induction and maintenance of allodynia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; ATP-Binding Cassette Transporters; Capsaicin; Dinoprost; Dinoprostone; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Pain; Pain Measurement; Physical Stimulation; Posterior Horn Cells; Receptors, Glutamate; Synapses; Synaptic Transmission; Touch | 2001 |
Pituitary hormone and insulin responses to infusion of amino acids and N-methyl-D,L-aspartate in horses.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Female; Glutamic Acid; Growth Hormone; Horses; Insulin; Lysine; Male; N-Methylaspartate; Pituitary Hormones; Prolactin; Radioimmunoassay; Thyrotropin | 2001 |
Expression and regulation of Na pump isoforms in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport; Cerebellum; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Isoenzymes; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Potassium Radioisotopes; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase | 2001 |
Phosphorylation of protein phosphatase inhibitor-1 by Cdk5.
Topics: Animals; Binding Sites; Brain; Calcineurin; Carrier Proteins; CDC2 Protein Kinase; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Kinetics; Mice; Mice, Inbred C57BL; Mutagenesis, Site-Directed; N-Methylaspartate; Phosphoprotein Phosphatases; Phosphorylation; Proline; Protein Phosphatase 1; Rabbits; Rats; Recombinant Proteins; RNA-Binding Proteins; Serine; Time Factors | 2001 |
Evaluation of agonist selectivity for the NMDA receptor ion channel in bilayer lipid membranes based on integrated single-channel currents.
Topics: Amino Acids, Dicarboxylic; Animals; Biosensing Techniques; CHO Cells; Cricetinae; Excitatory Amino Acid Agonists; Glutamic Acid; In Vitro Techniques; Ion Channels; Lipid Bilayers; Mice; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins | 2000 |
Study the mechanisms of U-50,488 to prevent the development of morphine tolerance in guinea pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Drug Tolerance; Excitatory Amino Acid Agonists; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Male; Morphine; N-Methylaspartate; Narcotics; Nitric Oxide; Pain Threshold; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tritium | 2000 |
Glutamate release via NO production evoked by NMDA in the NTS enhances hypotension and bradycardia in vivo.
Topics: Animals; Blood Pressure; Bradycardia; Calcium; Glutamic Acid; Heart Rate; Hypotension; Infusions, Parenteral; Male; Microdialysis; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Penicillamine; Rats; Rats, Inbred WKY; Receptors, N-Methyl-D-Aspartate; S-Nitroso-N-Acetylpenicillamine; Solitary Nucleus | 2001 |
Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation.
Topics: Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Biological Transport; Body Weight; Brain Chemistry; Creatine; Dicarboxylic Acids; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Glutamine; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Microdialysis; Motor Activity; Motor Neuron Disease; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Oxidative Stress; Psychomotor Performance; Pyrrolidines; Superoxide Dismutase | 2001 |
Regulation of sensorimotor gating in rats by hippocampal NMDA: anatomical localization.
Topics: Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Male; N-Methylaspartate; Neural Inhibition; Neural Pathways; Neurons; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia | 2001 |
Presynaptic N-methyl-D-aspartate receptor activation inhibits neurotransmitter release through nitric oxide formation in rat hippocampal nerve terminals.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbon Radioisotopes; Excitatory Amino Acid Agonists; Exocytosis; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Nitric Oxide; Presynaptic Terminals; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Synaptosomes; Tritium | 2001 |
Interleukin-10 prevents glutamate-mediated cerebellar granule cell death by blocking caspase-3-like activity.
Topics: Animals; Apoptosis; Calcium; Caspase 3; Caspase Inhibitors; Cells, Cultured; Cerebellum; DNA; Dose-Response Relationship, Drug; Glutamic Acid; Interleukin-10; N-Methylaspartate; Neurons; Neuroprotective Agents; NF-kappa B; Patch-Clamp Techniques; Protease Inhibitors; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2001 |
Glutamate does not play a major role in controlling bone growth.
Topics: 2-Amino-5-phosphonovalerate; Alveolar Bone Loss; Amino Acid Transport System X-AG; Animals; Animals, Newborn; ATP-Binding Cassette Transporters; Biological Transport; Bone Diseases, Metabolic; Bone Remodeling; Bone Resorption; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Femur; Glutamic Acid; Glycine; Humerus; Mandible; Mice; Mice, Knockout; Models, Animal; N-Methylaspartate; Osteoblasts; Osteoclasts; Osteogenesis; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2001 |
The N-methyl-D-aspartate antagonist memantine has no neuroprotective effect during hypothermic circulatory arrest: a study in the chronic porcine model.
Topics: Animals; Behavior, Animal; Brain; Cardiopulmonary Bypass; Electroencephalography; Female; Glucose; Glutamic Acid; Glycerol; Heart Arrest, Induced; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Lactic Acid; Memantine; Microdialysis; N-Methylaspartate; Neuroprotective Agents; Swine | 2001 |
Vasorelaxation induced by L-glutamate in porcine coronary arteries.
Topics: Animals; Aspartic Acid; Coronary Vessels; Drug Interactions; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Histamine; N-Methylaspartate; Potassium; Swine; Vasodilation | 2001 |
Relapse to cocaine-seeking after hippocampal theta burst stimulation.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Electric Stimulation; Electrodes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extinction, Psychological; Glutamic Acid; Hippocampus; Injections, Intravenous; Kynurenic Acid; Medial Forebrain Bundle; Memory; N-Methylaspartate; Rats; Rats, Long-Evans; Recurrence; Reward; Self Administration; Synaptic Transmission; Theta Rhythm; Ventral Tegmental Area | 2001 |
Electrophysiological characterization of "giant" cells in stratum radiatum of the CA3 hippocampal region.
Topics: 2-Amino-5-phosphonovalerate; 3,3'-Diaminobenzidine; Action Potentials; Animals; Axons; Bicuculline; Calcium; Cesium; Chlorides; Choline; Cyclopropanes; Dendrites; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Immunoenzyme Techniques; Microscopy, Video; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Propanolamines; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 2001 |
Bidirectional modulation of basal forebrain N-methyl-D-aspartate receptor function differentially affects visual attention but not visual discrimination performance.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Attention; Basal Nucleus of Meynert; Cerebral Cortex; Cholinergic Fibers; Cues; Discrimination Learning; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; N-Methylaspartate; Neural Pathways; Pattern Recognition, Visual; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2001 |
Effect of antioxidants on L-glutamate and N-methyl-4-phenylpyridinium ion induced-neurotoxicity in PC12 cells.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Cell Survival; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Kinetics; N-Methylaspartate; PC12 Cells; Rats; Receptors, N-Methyl-D-Aspartate | 2001 |
Further evidence for a role of NMDA receptors in the locus coeruleus in the expression of withdrawal syndrome from opioids.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Locus Coeruleus; Male; N-Methylaspartate; Naloxone; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2001 |
Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism.
Topics: Animals; Astrocytes; Buthionine Sulfoximine; Cell Communication; Cell Death; Coculture Techniques; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Glutathione; Mice; N-Methylaspartate; Neurons; Nitric Oxide | 2001 |
Dimethyl sulfoxide suppresses NMDA- and AMPA-induced ion currents and calcium influx and protects against excitotoxic death in hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Death; Cells, Cultured; Dimethyl Sulfoxide; Excitatory Amino Acid Agonists; Fluorescent Dyes; Fura-2; Glutamic Acid; Hippocampus; Ion Transport; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Receptors, Glutamate | 2001 |
MAP2 phosphorylation and visual plasticity in Xenopus.
Topics: Aging; Animals; Dendrites; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Agonists; Glutamic Acid; Immunoblotting; Microtubule-Associated Proteins; N-Methylaspartate; Neuronal Plasticity; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Superior Colliculi; Valine; Vision, Binocular; Visual Pathways; Xenopus laevis | 2001 |
Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons.
Topics: Action Potentials; Afferent Pathways; Animals; Cell Count; Dopamine; Dose-Response Relationship, Drug; Glutamic Acid; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Neurons; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Ventral Tegmental Area | 2001 |
Intrinsic optical signals in respiratory brain stem regions of mice: neurotransmitters, neuromodulators, and metabolic stress.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine; Adenosine Triphosphate; Animals; Animals, Newborn; Anti-Bacterial Agents; Antihypertensive Agents; Diazoxide; Energy Metabolism; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glyburide; Hypoglossal Nerve; Hypoglycemic Agents; Hypoxia; Kainic Acid; Macrolides; Mice; Mitochondrial Swelling; N-Methylaspartate; Optics and Photonics; Organ Culture Techniques; Ouabain; Potassium Channels; Respiratory Center; Sodium-Potassium-Exchanging ATPase; Tetrodotoxin | 2001 |
Protection against glutamate toxicity through inhibition of the p44/42 mitogen-activated protein kinase pathway in neuronally differentiated P19 cells.
Topics: Animals; Apoptosis; Butadienes; Cell Differentiation; Drug Interactions; Enzyme Inhibitors; Glutamic Acid; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neurons; Neuroprotective Agents; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, N-Methyl-D-Aspartate; Tumor Cells, Cultured | 2001 |
Glutamate inhibition of NMDA-induced hydroxyl radical release: an ontogenic study in rat.
Topics: Aging; Animals; Animals, Newborn; Brain; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hydroxyl Radical; Microdialysis; N-Methylaspartate; Neurons; Neurotoxins; Oxidative Stress; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Salicylates | 2001 |
Excitotoxic preconditioning elicited by both glutamate and hypoxia and abolished by lactate transport inhibition in rat hippocampal slices.
Topics: Action Potentials; Animals; Carrier Proteins; Coumaric Acids; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Hypoxia-Ischemia, Brain; Ischemic Preconditioning; Lactic Acid; Male; N-Methylaspartate; Neurons; Neurotoxins; Organ Culture Techniques; Rats; Rats, Sprague-Dawley | 2001 |
Characterization of ionotropic glutamate receptors in human lymphocytes.
Topics: 2-Amino-5-phosphonovalerate; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antibodies, Monoclonal; Calcium; CD3 Complex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Kainic Acid; Lymphocytes; N-Methylaspartate; Phytohemagglutinins; Quinoxalines; Receptors, Glutamate | 2001 |
Altered content and modulation of soluble guanylate cyclase in the cerebellum of rats with portacaval anastomosis.
Topics: Animals; Cerebellum; Cyclic GMP; Disease Models, Animal; Enzyme Activators; Excitatory Amino Acid Agonists; Glutamic Acid; Guanylate Cyclase; Hepatic Encephalopathy; Hyperammonemia; Immunoblotting; Indazoles; Lymphocytes; Male; Microdialysis; N-Methylaspartate; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; S-Nitroso-N-Acetylpenicillamine; Synaptic Transmission | 2001 |
Excitatory mechanisms in neuroleptic-induced vacuous chewing movements (VCMs): possible involvement of calcium and nitric oxide.
Topics: Animals; Antipsychotic Agents; Calcium; Dyskinesia, Drug-Induced; Glutamic Acid; Haloperidol; Male; Mastication; N-Methylaspartate; Nitric Oxide; Rats; Rats, Wistar; Stereotyped Behavior | 2001 |
Gating and braking of short- and long-term modulatory effects by interactions between colocalized neuromodulators.
Topics: Animals; Biological Clocks; Calcineurin Inhibitors; Dopamine; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Lampreys; Locomotion; Male; N-Methylaspartate; Nerve Net; Neuronal Plasticity; Neurons; Neurotransmitter Agents; Protein Binding; Serotonin; Spinal Cord; Substance P; Synaptic Transmission | 2001 |
Developmental depression of glutamate neurotransmission by chronic low-level activation of NMDA receptors.
Topics: Aging; Animals; Animals, Newborn; Down-Regulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; Glutamic Acid; In Vitro Techniques; Magnesium; N-Methylaspartate; Neural Inhibition; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Superior Colliculi; Synapses; Synaptic Transmission | 2001 |
Amphetamine-induced plasticity of AMPA receptors in the ventral tegmental area: effects on extracellular levels of dopamine and glutamate in freely moving rats.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Disease Models, Animal; Dopamine; Extracellular Space; Glutamic Acid; Male; Microdialysis; Microinjections; N-Methylaspartate; Neuronal Plasticity; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synaptic Transmission; Ventral Tegmental Area; Wakefulness | 2001 |
Dual effects of interleukin-1beta on N-methyl-D-aspartate-induced retinal neuronal death in rat eyes.
Topics: Animals; Cell Death; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Excitatory Amino Acid Agonists; Eye Diseases; Glutamic Acid; Immunohistochemistry; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retina; Sialoglycoproteins; Up-Regulation | 2001 |
Glutamate, NMDA, and AMPA induced changes in extracellular space volume and tortuosity in the rat spinal cord.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Death; Chelating Agents; Diffusion; Dizocilpine Maleate; Edema; Egtazic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Gliosis; Glutamic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Magnesium; N-Methylaspartate; Potassium; Rats; Rats, Wistar; Spinal Cord | 2001 |
Excitotoxic destruction facilitates brain tumor growth.
Topics: Animals; Brain Neoplasms; Glioma; Glutamic Acid; Humans; N-Methylaspartate | 2001 |
Glomerulus-specific synchronization of mitral cells in the olfactory bulb.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Kinetics; N-Methylaspartate; Olfactory Bulb; Olfactory Receptor Neurons; Periodicity; Quinoxalines; Rats; Rats, Sprague-Dawley; Smell | 2001 |
Absence of evidence is not evidence of absence. Redundancy blocks determination of cause and effect.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Bone Resorption; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Osteoblasts; Osteogenesis; Receptors, N-Methyl-D-Aspartate | 2001 |
Absence of evidence is not evidence of absence. The shortcomings of the GLAST knockout mouse.
Topics: Amino Acid Transport System X-AG; Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Mice; Mice, Knockout; N-Methylaspartate; Osteoblasts; Osteogenesis | 2001 |
Two distinct types of repetitive bursting activity mediated by NMDA in hypothalamic neurons in vitro.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Extracellular Space; Female; Glutamic Acid; Guinea Pigs; Hypothalamus; Magnesium Deficiency; N-Methylaspartate; Neurons; Nickel; Organ Culture Techniques; Patch-Clamp Techniques; Periodicity; Potassium Channel Blockers; Potassium Channels; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tetrodotoxin | 2001 |
N-acetylaspartylglutamate (NAAG) is the probable mediator of axon-to-glia signaling in the crayfish medial giant nerve fiber.
Topics: Animals; Aspartic Acid; Astacoidea; Axons; Carboxypeptidases; Cell Communication; Cysteic Acid; Dipeptides; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamate Carboxypeptidase II; Glutamic Acid; Membrane Potentials; N-Methylaspartate; Nervous System; Neuroglia; Organophosphorus Compounds; Receptors, Glutamate; Signal Transduction; Time Factors | 2001 |
Effects of volatile anesthetics on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cultures.
Topics: Anesthetics, Inhalation; Animals; Calcium; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamic Acid; Membrane Potentials; Mitochondria; N-Methylaspartate; Neuroglia; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2001 |
Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Action Potentials; Animals; Anticonvulsants; Benzoates; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Mice; Mice, Knockout; Muscarine; Muscarinic Agonists; N-Methylaspartate; Neostriatum; Neurons; Phenylacetates; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Synaptic Transmission | 2001 |
The pituitary adenylate cyclase-activating polypeptide modulates glutamatergic calcium signalling: investigations on rat suprachiasmatic nucleus neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cyclic AMP; Drug Interactions; Fluorescent Dyes; Fura-2; Glutamic Acid; N-Methylaspartate; Neurons; Neuropeptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Suprachiasmatic Nucleus | 2001 |
Tritium partitioning and isotope effects in adenosylcobalamin-dependent glutamate mutase.
Topics: Chromatography, High Pressure Liquid; Cobamides; Escherichia coli; Glutamic Acid; Intramolecular Transferases; Isotopes; Kinetics; N-Methylaspartate; Protein Binding; Thermodynamics; Time Factors; Triose-Phosphate Isomerase; Tritium | 2001 |
Multiple pathways of Pb(2+) permeation in rat cerebellar granule neurones.
Topics: Animals; Cells, Cultured; Cerebellum; Fluorescent Dyes; Fura-2; Glutamic Acid; Lead; N-Methylaspartate; Neurons; Permeability; Potassium Chloride; Rats; Rats, Sprague-Dawley; Solutions | 2001 |
Neurotoxic and neuroprotective effects of glutamate are enhanced by introduction of amyloid precursor protein cDNA.
Topics: Amyloid beta-Protein Precursor; Animals; Brain; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; DNA, Complementary; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Genetic Vectors; Glutamic Acid; Hippocampus; Membrane Potentials; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Peptide Fragments; Potassium Chloride; Rats; Receptors, Glutamate | 2001 |
Changes in the glutamate release and uptake of cerebellar cells in perinatally nicotine-exposed rat pups.
Topics: Animals; Animals, Newborn; Cerebellum; Dizocilpine Maleate; Female; Glutamic Acid; Male; N-Methylaspartate; Neurons; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2001 |
Nitric oxide produced by non-motoneuron cells enhances rat embryonic motoneuron sensitivity to excitotoxins: comparison in mixed neuron/glia or purified cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Cell Communication; Cell Differentiation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Kainic Acid; Magnesium; N-Methylaspartate; Neuroglia; Neurotoxins; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2001 |
Dopamine release in the prefrontal cortex during stress is reduced by the local activation of glutamate receptors.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dicarboxylic Acids; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Homovanillic Acid; Male; Microdialysis; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Prefrontal Cortex; Pyrrolidines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Stress, Physiological; Synaptic Transmission | 2001 |
Somatostatin release by glutamate in vivo is primarily regulated by AMPA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basal Ganglia; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Somatostatin | 2001 |
NMDA-mediated increase in renal sympathetic nerve discharge within the PVN: role of nitric oxide.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Kidney; Microinjections; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Paraventricular Hypothalamic Nucleus; Rats; Receptors, N-Methyl-D-Aspartate; Sympathetic Nervous System | 2001 |
GABA release induced by aspartate-mediated activation of NMDA receptors is modulated by dopamine in a selective subpopulation of amacrine cells.
Topics: Amacrine Cells; Animals; Aspartic Acid; Carrier Proteins; Cell Survival; Chickens; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Immunohistochemistry; Isoenzymes; Kainic Acid; L-Lactate Dehydrogenase; Membrane Proteins; Membrane Transport Proteins; N-Methylaspartate; Organic Anion Transporters; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2001 |
Influence of serotonin on the glutamate-induced excitations of secondary vestibular neurons in the rat.
Topics: Animals; Evoked Potentials; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin Receptor Agonists; Vestibular Nuclei | 2001 |
Distance-dependent increase in AMPA receptor number in the dendrites of adult hippocampal CA1 pyramidal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Axons; Dendrites; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Kinetics; Microinjections; N-Methylaspartate; Neural Pathways; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses | 2001 |
Reverse microdialysis of N-methyl-D-aspartic acid into the lateral hypothalamus of rats: effects on feeding and other behaviors.
Topics: Animals; Behavior, Animal; Circadian Rhythm; Dose-Response Relationship, Drug; Eating; Excitatory Amino Acid Agonists; Feeding Behavior; Glutamic Acid; Grooming; Hypothalamic Area, Lateral; Male; Microdialysis; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sleep | 2001 |
Magnesium decreases arterial pressure and inhibits cardiovascular responses induced by N-methyl-D-aspartate and metabotropic glutamate receptors stimulation in rostral ventrolateral medulla.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Heart Rate; Magnesium; Magnesium Chloride; Magnesium Sulfate; Male; Medulla Oblongata; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2001 |
Involvement of capsaicin-sensitive fibers in spinal NMDA-induced glutamate release.
Topics: Animals; Animals, Newborn; Capsaicin; Excitatory Amino Acid Agonists; Glutamic Acid; Injections, Spinal; Lumbar Vertebrae; Male; N-Methylaspartate; Nerve Fibers; Neurons, Afferent; Nitric Oxide; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 2001 |
Effects of glutamate receptor agonist on extracellular glutamate dynamics during moderate cerebral ischemia.
Topics: Animals; Carotid Artery, Common; Cerebrovascular Circulation; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Ischemic Attack, Transient; Kainic Acid; Male; Microdialysis; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Glutamate; Stroke | 2001 |
Role of glial glutamate transporters in the facilitatory action of FK960 on hippocampal neurotransmission.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Benzamides; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dentate Gyrus; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Female; Glutamic Acid; Indoles; Isoquinolines; Kainic Acid; Long-Term Potentiation; Maleimides; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nootropic Agents; Oocytes; Patch-Clamp Techniques; Perforant Pathway; Piperazines; Protein Synthesis Inhibitors; Rats; Receptors, Glutamate; Recombinant Fusion Proteins; Signal Transduction; Sulfonamides; Synaptic Transmission; Xenopus laevis | 2001 |
Sensitization of glutamate release and N-methyl-D-aspartate receptor response by transient dopamine pretreatment in prefrontal cortex of rats.
Topics: Animals; Avoidance Learning; Calcium Signaling; Dopamine; Dopamine Antagonists; Excitatory Amino Acid Agonists; Glutamic Acid; Habituation, Psychophysiologic; Immobilization; Memory; Microdialysis; Microscopy, Video; N-Methylaspartate; Pain; Perfusion; Prefrontal Cortex; Rats; Receptors, N-Methyl-D-Aspartate; Reserpine; Septum Pellucidum; Stress, Physiological; Synaptic Transmission; Tetrodotoxin | 2002 |
Dual mechanisms of Ca(2+) increases elicited by N-methyl-D-aspartate in immature and mature cultured cortical neurons.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Differentiation; Cells, Cultured; Cerebral Cortex; Dantrolene; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Fluorescent Dyes; Glial Fibrillary Acidic Protein; Glutamic Acid; Intracellular Fluid; Ionophores; Magnesium Chloride; Microscopy, Confocal; Microtubule-Associated Proteins; Muscle Relaxants, Central; N-Methylaspartate; Neurons; Potassium Chloride; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2002 |
Extracellular taurine as a parameter to monitor cerebral insults 'on-line': time courses and mechanisms as studied in vivo.
Topics: Animals; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Hypotonic Solutions; Male; N-Methylaspartate; Potassium; Rats; Rats, Wistar; Taurine; Time Factors; Water-Electrolyte Balance | 2000 |
cGMP-induced presynaptic depression and postsynaptic facilitation at glutamatergic synapses in visual cortex.
Topics: Animals; Calcium; Calcium Channels; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; N-Methylaspartate; Neural Inhibition; Neurons; Oligopeptides; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Visual Cortex | 2002 |
Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits.
Topics: Animals; Calcium; Cations, Divalent; Central Nervous System; Cloning, Molecular; Electrophysiology; Glutamic Acid; Glycine; Immunohistochemistry; In Situ Hybridization; Ion Transport; Magnesium; Molecular Sequence Data; N-Methylaspartate; Neurons; Oocytes; Protein Subunits; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sequence Homology; Serine; Substrate Specificity; Xenopus laevis | 2002 |
Differential control of vesicle priming and short-term plasticity by Munc13 isoforms.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Dizocilpine Maleate; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Intracellular Signaling Peptides and Proteins; Mice; Mice, Knockout; N-Methylaspartate; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Protein Isoforms; Synaptic Transmission; Synaptic Vesicles; Thiazoles; Thiazolidines; Type C Phospholipases | 2002 |
Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hippocampus; Hypoxia-Ischemia, Brain; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Pyramidal Cells; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2002 |
Glutamate mediated responses in isolated trachea preparations from control and ovalbumin sensitized guinea-pigs.
Topics: 2-Amino-5-phosphonovalerate; Animals; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; N-Methylaspartate; Ovalbumin; Receptors, Glutamate; Trachea | 2002 |
Glutamate receptor desensitization block potentiates the stimulated GABA release through external Ca2+-independent mechanisms from granule cells of olfactory bulb.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Neurons; Olfactory Bulb; Potassium Chloride; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 2001 |
Effects of metabotropic glutamate receptor agonists and antagonists on D-aspartate release from mouse cerebral cortical and striatal slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred Strains; N-Methylaspartate; Receptors, Metabotropic Glutamate; Tritium | 2001 |
E-p-methoxycinnamic acid protects cultured neuronal cells against neurotoxicity induced by glutamate.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Cinnamates; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2002 |
Different action of memantine and caroverine on glutamatergic transmission in the mammalian cochlea.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cochlea; Dopamine Agents; Female; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory, Inner; Memantine; N-Methylaspartate; Neurons, Afferent; Quinoxalines | 2002 |
Episodic bursting activity and response to excitatory amino acids in acutely dissociated gonadotropin-releasing hormone neurons genetically targeted with green fluorescent protein.
Topics: Action Potentials; Animals; Biological Clocks; Cell Separation; Cells, Cultured; Excitatory Amino Acids; Female; Glutamic Acid; Gonadotropin-Releasing Hormone; Green Fluorescent Proteins; In Vitro Techniques; Luminescent Proteins; Membrane Potentials; Mice; Mice, Transgenic; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Promoter Regions, Genetic | 2002 |
Glutamate-induced excitotoxicity in retina: neuroprotection with receptor antagonist, dextromethorphan, but not with calcium channel blockers.
Topics: Animals; Calcium Channel Blockers; Cell Death; Dextromethorphan; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Laser Coagulation; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Rabbits; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Verapamil | 2002 |
GABA interacts with photic signaling in the suprachiasmatic nucleus to regulate circadian phase shifts.
Topics: Animals; Baclofen; Circadian Rhythm; Cricetinae; Excitatory Amino Acid Agonists; GABA Agonists; GABA-A Receptor Agonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mesocricetus; Muscimol; N-Methylaspartate; Neural Inhibition; Neurons; Photic Stimulation; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Suprachiasmatic Nucleus; Synaptic Transmission; Tetrodotoxin | 2002 |
NMDA and AMPA/kainate glutamatergic agonists increase the extracellular concentrations of GABA in the prefrontal cortex of the freely moving rat: modulation by endogenous dopamine.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dopamine; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Male; N-Methylaspartate; Neurons; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Up-Regulation | 2002 |
A comparison of some metabolic effects of N-methylaspartate stereoisomers, glutamate and depolarization: a multinuclear MRS study.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Dizocilpine Maleate; Electrophysiology; Energy Metabolism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Lactic Acid; Magnetic Resonance Spectroscopy; N-Methylaspartate; Osmolar Concentration; Phosphocreatine; Stereoisomerism | 2002 |
Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Free Radical Scavengers; Furans; Glutamic Acid; Kainic Acid; Lignans; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Peroxides; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid | 2002 |
Superoxide modification and inactivation of a neuronal receptor-like complex.
Topics: Animals; Cysteine; Ethylmaleimide; Glutamic Acid; Membrane Proteins; N-Methylaspartate; Point Mutation; Protein Binding; Rats; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Superoxides; Synaptic Membranes; Tritium; Xanthine; Xanthine Oxidase | 2002 |
Electrophysiological characterization of retinal Müller glial cells from mouse during postnatal development: comparison with rabbit cells.
Topics: Aging; Animals; Animals, Newborn; Barium; Cell Differentiation; Cell Membrane; Electric Stimulation; Excitatory Amino Acid Transporter 2; Female; Glutamic Acid; Ion Channels; Male; Membrane Potentials; Mice; N-Methylaspartate; Neuroglia; Potassium Channels; Rabbits; Receptors, N-Methyl-D-Aspartate; Retina; Sodium Channels | 2002 |
Expression of functional N-methyl-D-aspartate receptors during development of chick embryo retina cells: in vitro versus in vivo studies.
Topics: Animals; Calcium; Calcium Signaling; Cell Differentiation; Cells, Cultured; Chick Embryo; Gene Expression Regulation, Developmental; Glutamic Acid; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Retina; Synaptic Transmission; Up-Regulation | 2002 |
NOC/oFQ and NMDA contribute to piglet hypoxic ischemic hypotensive cerebrovasodilation impairment.
Topics: Animals; Animals, Newborn; Cerebrovascular Circulation; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hypotension; Hypoxia-Ischemia, Brain; Intracranial Hypertension; Male; N-Methylaspartate; Narcotic Antagonists; Neuroprotective Agents; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Pia Mater; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Shock, Hemorrhagic; Swine; Vasodilation | 2002 |
Spike-independent release of ATP from Xenopus spinal neurons evoked by activation of glutamate receptors.
Topics: Adenosine Triphosphate; Animals; Cadmium; Calcium Channels, L-Type; Calcium Channels, N-Type; Embryo, Nonmammalian; Glutamic Acid; Motor Activity; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Potassium; Pyridoxal Phosphate; Receptors, Glutamate; Spinal Cord; Tetrodotoxin; Xenopus | 2002 |
Synergistic versus antagonistic actions of glutamate and glutathione: the role of excitotoxicity and oxidative stress in neuronal disease.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flour; Glutamic Acid; Glutathione; Kynurenic Acid; L-Lactate Dehydrogenase; Male; Methionine Sulfoximine; Mice; Mice, Inbred Strains; N-Methylaspartate; Nervous System Diseases; Oxidative Stress; Plants, Toxic; Rats; Rats, Sprague-Dawley; Sitosterols | 2002 |
Phenformin suppresses calcium responses to glutamate and protects hippocampal neurons against excitotoxicity.
Topics: Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cytoprotection; Dose-Response Relationship, Drug; Glutamic Acid; Hippocampus; Hypoglycemic Agents; Immunoblotting; N-Methylaspartate; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Phenformin; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2002 |
[Effect of excitatoxicity on Ca2+/CaM PK II activity in rat hippocampal slices].
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
Protection of cultured rat cortical neurons from excitotoxicity by asarone, a major essential oil component in the rhizomes of Acorus gramineus.
Topics: Acorus; Allylbenzene Derivatives; Animals; Anisoles; Cell Death; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Medicine, East Asian Traditional; N-Methylaspartate; Neurons; Neuroprotective Agents; Plant Extracts; Pregnancy; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2002 |
Effects of bilobalide on amino acid release and electrophysiology of cortical slices.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Cyclopentanes; Diterpenes; Electrophysiology; Furans; Ginkgolides; Glutamic Acid; In Vitro Techniques; Magnesium; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; N-Methylaspartate; Neurotransmitter Agents; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Oximes; Potassium; Veratridine | 2002 |
Ergothioneine treatment protects neurons against N-methyl-D-aspartate excitotoxicity in an in vivo rat retinal model.
Topics: Amyloid beta-Protein Precursor; Animals; Antioxidants; Astrocytes; Cell Count; Cell Death; Disease Models, Animal; Down-Regulation; Ergothioneine; Female; Glial Fibrillary Acidic Protein; Glutamic Acid; N-Methylaspartate; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells | 2002 |
Contribution of N-methyl-d-aspartate receptors in the anteroventral third ventricular region to vasopressin secretion, but not to cardiovascular responses provoked by hyperosmolality and prostaglandin E2 in conscious rats.
Topics: Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Consciousness; Dinoprostone; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Hypothalamus; Male; N-Methylaspartate; Preoptic Area; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Saline Solution, Hypertonic; Synaptic Transmission; Third Ventricle; Vasopressins; Water-Electrolyte Balance | 2002 |
Comparison of the neuroprotective effects of adrenoceptor drugs in retinal cell culture and intact retina.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Brimonidine Tartrate; Calcium; Cell Culture Techniques; Cell Survival; Dose-Response Relationship, Drug; Fura-2; Glutamic Acid; Metoprolol; N-Methylaspartate; Neuroglia; Neuroprotective Agents; Quinoxalines; Rats; Rats, Long-Evans; Retina; Retinal Ganglion Cells; Timolol | 2002 |
Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons.
Topics: Animals; Animals, Newborn; Calcium Signaling; Cells, Cultured; Central Nervous System Agents; Excitatory Amino Acid Agonists; Fluorescent Dyes; Fura-2; Ginsenosides; Glutamic Acid; Herbal Medicine; Hippocampus; N-Methylaspartate; Neurons; Panax; Patch-Clamp Techniques; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Saponins | 2002 |
Effects of xenon on in vitro and in vivo models of neuronal injury.
Topics: Anesthetics, Inhalation; Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; L-Lactate Dehydrogenase; Mice; Mice, Inbred BALB C; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Xenon | 2002 |
Spinal cord heme oxygenase participates in glutamate-induced pain-related behaviors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cyclic GMP; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Heme Oxygenase (Decyclizing); In Vitro Techniques; Injections, Spinal; Male; Mesoporphyrins; Metalloporphyrins; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Pain; Protoporphyrins; Spinal Cord | 2002 |
Glutamate cascade to cAMP response element-binding protein phosphorylation in cultured striatal neurons through calcium-coupled group I metabotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzopyrans; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Drug Interactions; Glutamic Acid; Kainic Acid; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Phosphorylation; Rats; Receptors, Metabotropic Glutamate; Type C Phospholipases | 2002 |
Phosphorylation of glial fibrillary acidic protein is stimulated by glutamate via NMDA receptors in cortical microslices and in mixed neuronal/glial cell cultures prepared from the cerebellum.
Topics: Animals; Animals, Newborn; Astrocytes; Cell Differentiation; Cells, Cultured; Cerebellum; Coculture Techniques; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glial Fibrillary Acidic Protein; Glutamic Acid; Intermediate Filaments; Male; N-Methylaspartate; Neurons; Phosphorylation; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2002 |
Relationship between NOC/oFQ, dynorphin, and COX-2 activation in impaired NMDA cerebrovasodilation after brain injury.
Topics: Animals; Animals, Newborn; Brain Injuries; Cyclooxygenase 2; Dynorphins; Enzyme Activation; Female; Glutamic Acid; Indomethacin; Isoenzymes; Male; N-Methylaspartate; Naltrexone; Nitrobenzenes; Nociceptin; Opioid Peptides; Pia Mater; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Superoxides; Swine; Vasodilation | 2002 |
Nitric oxide synthase inhibition and glutamate binding in quinolinate-lesioned rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cell Membrane; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Kainic Acid; Male; Molsidomine; N-Methylaspartate; Nerve Degeneration; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Quinolinic Acid; Quisqualic Acid; Rats; Rats, Wistar; Tritium | 2002 |
Immune-related mechanisms participating in resistance and susceptibility to glutamate toxicity.
Topics: Animals; Apoptosis Regulatory Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Death; Cell Survival; Death-Associated Protein Kinases; Disease Susceptibility; Dizocilpine Maleate; Dose-Response Relationship, Drug; Genes, bcl-2; Glutamic Acid; Immunity, Innate; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; N-Methylaspartate; Retinal Ganglion Cells; Species Specificity | 2002 |
Facilitation of glutamate release by ionotropic glutamate receptors in osteoblasts.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Division; Cells, Cultured; Glutamic Acid; Kainic Acid; N-Methylaspartate; Osteoblasts; Potassium Chloride; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Reverse Transcriptase Polymerase Chain Reaction; Skull | 2002 |
Mouse cerebellar adenosine-glutamate interactions and modulation of ethanol-induced motor incoordination.
Topics: Animals; Cerebellum; Dose-Response Relationship, Drug; Ethanol; Glutamic Acid; Male; Mice; Motor Skills; N-Methylaspartate; Psychomotor Performance; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1 | 2002 |
N-Methyl-D-aspartate receptor subtype-selectivity of homoquinolinate: an electrophysiological and radioligand binding study using both native and recombinant receptors.
Topics: Animals; Binding Sites; Binding, Competitive; Brain Chemistry; Cell Line; Cell Membrane; Fibroblasts; Glutamic Acid; Humans; Mice; N-Methylaspartate; Patch-Clamp Techniques; Quinolinic Acids; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Substrate Specificity | 2002 |
N-Methyl-D-aspartate receptor activation inhibits protein synthesis in cortical neurons independently of its ionic permeability properties.
Topics: Animals; Calcium; Cell Membrane Permeability; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Eukaryotic Initiation Factor-2; Excitatory Amino Acid Agonists; Glutamic Acid; Mice; N-Methylaspartate; Neurons; Phosphorylation; Protein Biosynthesis; Receptors, N-Methyl-D-Aspartate; Thapsigargin | 2002 |
In vivo temporal sequence of rat striatal glutamate, aspartate and dopamine efflux during apomorphine, nomifensine, NMDA and PDC in situ administration.
Topics: Animals; Apomorphine; Aspartic Acid; Dicarboxylic Acids; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Electrodes, Implanted; Electrophoresis, Capillary; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Microdialysis; N-Methylaspartate; Neostriatum; Neurotransmitter Uptake Inhibitors; Nomifensine; Online Systems; Pyrrolidines; Rats; Rats, Sprague-Dawley | 2002 |
Non-linear effects of cycloheximide in glutamate-treated cultured rat cerebellar neurons.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebellum; Cycloheximide; Excitatory Amino Acid Agonists; Glutamic Acid; Lethal Dose 50; N-Methylaspartate; Neurons; Neuroprotective Agents; Nonlinear Dynamics; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley | 2002 |
Striatal dopamine-NMDA receptor interactions in the modulation of glutamate release in the substantia nigra pars reticulata in vivo: opposite role for D1 and D2 receptors.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Glutamic Acid; Male; Microdialysis; N-Methylaspartate; Oxidopamine; Parkinsonian Disorders; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Wakefulness | 2002 |
Carbon monoxide and metabotropic glutamate receptors in rat nucleus tractus solitarii: participation in cardiovascular effect.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Carbon Monoxide; Cardiovascular System; Cycloleucine; Deuteroporphyrins; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Heme Oxygenase (Decyclizing); Hemin; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Solitary Nucleus | 2002 |
Barbiturates induce mitochondrial depolarization and potentiate excitotoxic neuronal death.
Topics: Amobarbital; Animals; Barbiturates; Calcium; Cell Death; Cells, Cultured; Drug Synergism; Fluorescent Dyes; Glutamic Acid; Mitochondria; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Secobarbital | 2002 |
Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation.
Topics: Animals; Calcimycin; Calpain; Cells, Cultured; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Glutamic Acid; Ionomycin; Ionophores; N-Methylaspartate; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurofibrillary Tangles; Neurons; Phosphorylation; Rats; tau Proteins | 2002 |
The activation of serotonin receptors prevents glutamate-induced neurotoxicity and NMDA-stimulated cGMP accumulation in primary cortical cell cultures.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cell Survival; Cells, Cultured; Cyclic GMP; Glutamic Acid; Indophenol; N-Methylaspartate; Neocortex; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Receptor Agonists | 2002 |
Selective muscarinic regulation of functional glutamatergic Schaffer collateral synapses in rat CA1 pyramidal neurons.
Topics: Adenosine; Animals; Carbachol; Cholinergic Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; N-Methylaspartate; Neural Inhibition; Presynaptic Terminals; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Muscarinic; Synapses | 2002 |
NMDA-evoked excitotoxicity increases tissue transglutaminase in cerebellar granule cells.
Topics: Animals; Animals, Newborn; Calcium Signaling; Cells, Cultured; Cerebellar Cortex; Excitatory Amino Acid Antagonists; Glutamic Acid; Membrane Potentials; N-Methylaspartate; Neurodegenerative Diseases; Neurons; Neurotoxins; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Transglutaminases; Up-Regulation | 2002 |
Regulation of glutamatergic neurotransmission in the striatum by presynaptic adenylyl cyclase-dependent processes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenergic beta-Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bucladesine; Calcium; Calmodulin; Corpus Striatum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Feedback; Female; Glutamic Acid; Imidazoles; Imines; Isoenzymes; Isoproterenol; Isoquinolines; Kainic Acid; Male; Mice; N-Methylaspartate; Nerve Tissue Proteins; Propranolol; Receptors, Adrenergic, beta; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Presynaptic; Second Messenger Systems; Sulfonamides; Synaptic Transmission; Trifluoperazine | 2003 |
L-citrulline recycling by argininosuccinate synthetase and lyase in rat gastric fundus.
Topics: Animals; Arginase; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Argininosuccinic Acid; Aspartic Acid; Citrulline; Dinoprost; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; Glutamic Acid; Glutamine; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Thiolester Hydrolases; Ubiquitin Thiolesterase | 2002 |
Neurokinin release in the rat nucleus of the solitary tract via NMDA and AMPA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dendrites; Excitatory Amino Acid Antagonists; Glutamic Acid; Immunohistochemistry; N-Methylaspartate; Neurokinin A; Neurokinin B; Presynaptic Terminals; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Solitary Nucleus; Substance P; Synaptic Transmission; Vagus Nerve; Visceral Afferents | 2002 |
Activation of NMDA receptors linked to modulation of voltage-gated ion channels and functional implications.
Topics: Animals; Calcium Channels, L-Type; Cobalt; Excitatory Amino Acid Antagonists; Glutamic Acid; Ictaluridae; Ion Channels; Membrane Potentials; N-Methylaspartate; Neurons; Photic Stimulation; Reaction Time; Receptors, N-Methyl-D-Aspartate; Retina; Sodium Channels; Synaptic Transmission; Tetrodotoxin; Vision, Ocular | 2003 |
Glutamatergic and serotonergic mechanisms in the dorsal facial area for common carotid artery blood flow control in the cat.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamines; Animals; Blood Flow Velocity; Blood Pressure; Carotid Artery, Common; Cats; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Female; Glutamates; Glutamic Acid; Heart Rate; Ketanserin; Male; Medulla Oblongata; Microinjections; N-Methylaspartate; Receptors, AMPA; Serotonin Antagonists; Serotonin Receptor Agonists | 2002 |
Role of serotonin, gamma-aminobutyric acid, and glutamate in the behavioral thermoregulation of female tilapia during the prespawning phase.
Topics: Animals; Behavior, Animal; Body Temperature Regulation; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Female; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Hypothalamus; Muscimol; N-Methylaspartate; Reproduction; Serotonin; Tilapia; Time Factors | 2002 |
Evidence against the presence of NMDA receptors at a central glutamatergic synapse in leeches.
Topics: 2-Amino-5-phosphonovalerate; Animals; Association Learning; Central Nervous System; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Kynurenic Acid; Leeches; Motor Neurons; N-Methylaspartate; Neurons, Afferent; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Reflex; Synapses; Synaptic Transmission | 2002 |
Pre-steady-state kinetic studies on the Glu171Gln active site mutant of adenosylcobalamin-dependent glutamate mutase.
Topics: Amino Acid Substitution; Binding Sites; Cobamides; Deuterium; Escherichia coli Proteins; Glutamic Acid; Glutamine; Intramolecular Transferases; Kinetics; Mutagenesis, Site-Directed; N-Methylaspartate; Recombinant Proteins; Spectrophotometry, Ultraviolet; Substrate Specificity | 2002 |
Dictyoquinazols A, B, and C, new neuroprotective compounds from the mushroom Dictyophora indusiata.
Topics: Agaricales; Animals; Cells, Cultured; Cerebellar Cortex; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glutamic Acid; Korea; Mice; Molecular Structure; N-Methylaspartate; Neurons; Neuroprotective Agents; Nuclear Magnetic Resonance, Biomolecular; Quinazolines; Stereoisomerism; Triterpenes | 2002 |
Neural progenitor cells resist excitatory amino acid-induced neurotoxicity.
Topics: Animals; Animals, Newborn; Calcium; Culture Techniques; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acids; Glial Fibrillary Acidic Protein; Glutamic Acid; Intermediate Filament Proteins; L-Lactate Dehydrogenase; Lactase-Phlorizin Hydrolase; N-Methylaspartate; Nerve Tissue Proteins; Nestin; Neurons; NG-Nitroarginine Methyl Ester; Nitric Acid; Nitrites; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Stem Cells | 2003 |
Glutamate and aspartate do not exhibit the same changes in their extracellular concentrations in the rat striatum after N-methyl-D-aspartate local administration.
Topics: Animals; Aspartic Acid; Corpus Striatum; Extracellular Space; Glutamic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
Involvement of acetylated tubulin in the regulation of Na+,K+ -ATPase activity in cultured astrocytes.
Topics: Acetylation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Ionophores; Mice; Monensin; N-Methylaspartate; Sodium-Potassium-Exchanging ATPase; Tubulin | 2003 |
Adenosine receptors mediate glutamate-evoked arteriolar dilation in the rat cerebral cortex.
Topics: Animals; Arterioles; Blood Pressure; Cerebrovascular Circulation; Excitatory Amino Acid Agonists; Glutamic Acid; Male; N-Methylaspartate; Pia Mater; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Triazines; Triazoles; Vasodilation | 2003 |
Adaptive changes in the rat hippocampal glutamatergic neurotransmission are observed during long-term treatment with lorazepam.
Topics: Adaptation, Physiological; Animals; Anti-Anxiety Agents; Cyclic GMP; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Lorazepam; Male; N-Methylaspartate; Potassium; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2003 |
Plasticity of glutamatergic control of striatal acetylcholine release in experimental parkinsonism: opposite changes at group-II metabotropic and NMDA receptors.
Topics: Acetylcholine; Animals; Antiparkinson Agents; Benserazide; Corpus Striatum; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Levodopa; Male; N-Methylaspartate; Neuronal Plasticity; Parkinsonian Disorders; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 2003 |
Modulation of glutamatergic transmission by bergmann glial cells in rat cerebellum in situ.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Cell Communication; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Membrane Potentials; N-Methylaspartate; Nerve Fibers; Neuroglia; Patch-Clamp Techniques; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Sodium; Synaptic Transmission | 2003 |
AMPA/kainate and NMDA-like glutamate receptors at the chromatophore neuromuscular junction of the squid: role in synaptic transmission and skin patterning.
Topics: Animals; Calcium; Chromatophores; Decapodiformes; Electric Stimulation; Electrophoresis, Polyacrylamide Gel; Excitatory Postsynaptic Potentials; Fluorescent Dyes; Fura-2; Glutamic Acid; Immunoblotting; Immunohistochemistry; In Vitro Techniques; Ion Channels; Iontophoresis; Muscle Contraction; Muscle Fibers, Skeletal; N-Methylaspartate; Neuromuscular Junction; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Skin Physiological Phenomena; Synaptic Transmission | 2003 |
Human immunodeficiency virus type 1 gp120 and ethanol coexposure in rat organotypic brain slice cultures: Curtailment of gp120-induced neurotoxicity and neurotoxic mediators by moderate but not high ethanol concentrations.
Topics: Animals; Arachidonic Acid; Brain; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; Glycine; HIV Envelope Protein gp120; N-Methylaspartate; Nerve Degeneration; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Superoxides | 2003 |
Protection of cortical neurons against oxygen-glucose deprivation and N-methyl-D-aspartate by DIDS and SITS.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Anaerobiosis; Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Female; Glucose; Glutamic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Oxygen; Pregnancy; Rats; Rats, Sprague-Dawley | 2003 |
Fast and slow locomotor burst generation in the hemispinal cord of the lamprey.
Topics: Action Potentials; Animals; Down-Regulation; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; In Vitro Techniques; Lampreys; Locomotion; N-Methylaspartate; Neural Inhibition; Spinal Cord; Spinal Nerve Roots; Swimming | 2003 |
Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.
Topics: Amino Acids; Anesthetics, Local; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dopamine; Drug Administration Routes; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Ketamine; Male; Microdialysis; N-Methylaspartate; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Tetrodotoxin; Time Factors | 2003 |
Dynamic pelvic-pudendal reflex plasticity mediated by glutamate in anesthetized rats.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Anesthesia; Animals; Bicuculline; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Laminectomy; N-Methylaspartate; Neural Pathways; Neuronal Plasticity; Pelvis; Quinoxalines; Rats; Rats, Wistar; Reflex; Urethra | 2003 |
Glutamate promotes proliferation of striatal neuronal progenitors by an NMDA receptor-mediated mechanism.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Division; Cells, Cultured; Corpus Striatum; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Image Cytometry; Injections, Intraperitoneal; Male; Maternal-Fetal Exchange; N-Methylaspartate; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Stem Cells | 2003 |
Halothane depresses glutamatergic neurotransmission to brain stem inspiratory premotor neurons in a decerebrate dog model.
Topics: Anesthetics, Inhalation; Animals; Bicuculline; Brain Stem; Decerebrate State; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; Halothane; Motor Neurons; N-Methylaspartate; Oxygen; Patch-Clamp Techniques; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2003 |
The influence of dorsomedial hypothalamic nucleus on contralateral paraventricular nucleus in NMDA-mediated cardiovascular responses.
Topics: Animals; Blood Pressure; Dorsomedial Hypothalamic Nucleus; Excitatory Amino Acid Agonists; Female; Functional Laterality; gamma-Aminobutyric Acid; Glutamic Acid; Heart Rate; Male; Microdialysis; Microinjections; N-Methylaspartate; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Time Factors | 2003 |
Modulation of the ability of clozapine to facilitate NMDA- and electrically evoked responses in pyramidal cells of the rat medial prefrontal cortex by dopamine: pharmacological evidence.
Topics: 5-Hydroxytryptophan; alpha-Methyltyrosine; Animals; Antipsychotic Agents; Benzazepines; Clozapine; Dopamine; Dopamine Agents; Dopamine Antagonists; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Levodopa; Male; N-Methylaspartate; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reserpine; Synaptic Transmission; Tyrosine 3-Monooxygenase | 2003 |
Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage.
Topics: Aminoquinolines; Animals; Binding, Competitive; Calcium; Cell Death; Cells, Cultured; Cerebellum; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gliosis; Glutamic Acid; Heat-Shock Proteins; Heterocyclic Compounds, 4 or More Rings; HSP27 Heat-Shock Proteins; Isoquinolines; Mice; Molecular Chaperones; Motor Activity; N-Methylaspartate; Neoplasm Proteins; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Propionates; Rats | 2003 |
Ethanol withdrawal hyper-responsiveness mediated by NMDA receptors in spinal cord motor neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cyclic AMP-Dependent Protein Kinases; Ethanol; Evoked Potentials, Motor; Excitatory Amino Acid Agonists; Glutamic Acid; In Vitro Techniques; Motor Neurons; N-Methylaspartate; Patch-Clamp Techniques; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Substance Withdrawal Syndrome | 2003 |
MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis.
Topics: AIDS Dementia Complex; Apoptosis; Astrocytes; Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Coculture Techniques; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gene Products, tat; Glutamic Acid; Humans; N-Methylaspartate; Neurons; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; tat Gene Products, Human Immunodeficiency Virus | 2003 |
Glutamate receptors regulate Na/K-ATPase in cerebellum neurons.
Topics: Animals; Cells, Cultured; Cerebellum; Cycloleucine; Glutamic Acid; Homeostasis; N-Methylaspartate; Neurons; Neurotoxins; Reactive Oxygen Species; Receptors, Glutamate; Sodium-Potassium-Exchanging ATPase | 2003 |
NMDA-type glutamate receptor is associated with cutaneous barrier homeostasis.
Topics: Animals; Calcium; Cells, Cultured; Dizocilpine Maleate; Epidermis; Glutamic Acid; Homeostasis; Humans; Hyperplasia; Immunohistochemistry; In Situ Hybridization; Keratinocytes; Male; Mice; Mice, Hairless; N-Methylaspartate; Permeability; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; Skin; Tissue Distribution; Water Loss, Insensible | 2003 |
Interleukin-6, beta-amyloid peptide and NMDA interactions in rat cortical neurons.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium Signaling; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Drug Interactions; Encephalitis; Excitatory Amino Acid Agonists; Fetus; Glutamic Acid; Interleukin-6; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
Preconditioning of cortical neurons by oxygen-glucose deprivation: tolerance induction through abbreviated neurotoxic signaling.
Topics: 2,4-Dinitrophenol; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Cerebral Cortex; Extracellular Space; Glucose; Glutamic Acid; Hypoxia; Ischemic Preconditioning; Mitochondria; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Uncoupling Agents | 2003 |
Species, strain and developmental variations in hippocampal neuronal and endothelial nitric oxide synthase clarify discrepancies in nitric oxide-dependent synaptic plasticity.
Topics: Animals; Citrulline; Endothelium, Vascular; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Immunohistochemistry; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Species Specificity; Synaptic Transmission | 2003 |
Extracellular concentrations of catecholamines and amino acids in the dorsomedial hypothalamus of kindled rats. A microdialysis study.
Topics: Animals; Bicuculline; Blood Pressure; Chromatography, High Pressure Liquid; Dopamine; Dorsomedial Hypothalamic Nucleus; Epilepsy; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Heart Rate; Kindling, Neurologic; Male; Microdialysis; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
Differential role of PTK, ERK and p38 MAPK in superoxide impairment of NMDA cerebrovasodilation.
Topics: Animals; Animals, Newborn; Arteries; Cerebral Cortex; Cerebrovascular Circulation; Enzyme Inhibitors; Female; Glutamic Acid; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; N-Methylaspartate; Pia Mater; Protein-Tyrosine Kinases; Superoxides; Swine; Vasodilation | 2003 |
Mechanisms of action of CHF3381 in the forebrain.
Topics: Animals; Anticonvulsants; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electrophysiology; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Indans; Injections, Intraperitoneal; Ion Channel Gating; Male; N-Methylaspartate; Neurons; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sodium Channels | 2003 |
Inner retinal neurons display differential responses to N-methyl-D-aspartate receptor activation.
Topics: Adrenergic beta-Antagonists; Agmatine; Amacrine Cells; Animals; Betaxolol; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Immunohistochemistry; N-Methylaspartate; Neurons; Rabbits; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Synaptic Transmission | 2003 |
Neuroprotective activity of p-terphenyl leucomentins from the mushroom Paxillus panuoides.
Topics: Agaricales; Alkenes; Animals; DNA Damage; Epoxy Compounds; Ferrous Compounds; Free Radicals; Glutamic Acid; Hydrogen Peroxide; Iron Chelating Agents; Lipid Peroxidation; Mice; Mice, Inbred ICR; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Terphenyl Compounds | 2003 |
Redox regulation of neuronal migration in a Down Syndrome model.
Topics: Acetylcysteine; Animals; Chemotaxis; Disease Models, Animal; Dithiothreitol; Down Syndrome; Fetus; Glutamic Acid; Mice; N-Methylaspartate; Neurons; Oxidation-Reduction; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Trisomy | 2003 |
Glycogen synthase kinase-3 inhibitors protect central neurons against excitotoxicity.
Topics: Aminophenols; Animals; Cell Survival; Cells, Cultured; Central Nervous System; Cerebellum; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycogen Synthase Kinase 3; Hippocampus; Indoles; Kainic Acid; Maleimides; N-Methylaspartate; Neurons; Neuroprotective Agents; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
Dorsal hippocampus and classical fear conditioning to tone and context in rats: effects of local NMDA-receptor blockade and stimulation.
Topics: Acoustic Stimulation; Animals; Avoidance Learning; Conditioning, Psychological; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fear; Glutamic Acid; Hippocampus; Male; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2003 |
Evidence for a glutamatergic modulation of the cholinergic function in the human enteric nervous system via NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Aged; Colon, Ascending; Colon, Sigmoid; Enteric Nervous System; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Immunohistochemistry; In Vitro Techniques; Kynurenic Acid; Male; Muscle, Smooth; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate | 2003 |
THE EXCITATION AND DEPRESSION OF MAMMALIAN CORTICAL NEURONES BY AMINO ACIDS.
Topics: Acetates; Amino Acids; Aminocaproates; Aminocaproic Acid; Animals; Aspartic Acid; Butyrates; Caprylates; Cats; Central Nervous System; Cerebral Cortex; Glutamic Acid; Hydroxybutyrates; N-Methylaspartate; Neurons; Pharmacology; Propionates; Research; Spinal Cord; Sulfonic Acids; Taurine | 1964 |
Beta-amyloid prevents excitotoxicity via recruitment of glial glutamate transporters.
Topics: Amino Acid Transport System X-AG; Amyloid beta-Peptides; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Cerebral Cortex; Colorimetry; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Peptide Fragments; Rats; Rats, Wistar | 2003 |
Effect of agmatine against cell death induced by NMDA and glutamate in neurons and PC12 cells.
Topics: Agmatine; Animals; Calcimycin; Cell Death; Cerebral Cortex; Enzyme Inhibitors; Fetus; Glutamic Acid; Ionophores; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; PC12 Cells; Protein Kinase Inhibitors; Protein Kinases; Rats; Staurosporine | 2003 |
On-line biosensors for simultaneous determination of glucose, choline, and glutamate integrated with a microseparation system.
Topics: Alcohol Oxidoreductases; Animals; Ascorbate Oxidase; Biosensing Techniques; Choline; Electrochemistry; Electrodes; Frontal Lobe; Glucose; Glucose Oxidase; Glutamic Acid; Horseradish Peroxidase; Microdialysis; Miniaturization; N-Methylaspartate; Rats | 2003 |
Haloperidol impairs auditory filial imprinting and modulates monoaminergic neurotransmission in an imprinting-relevant forebrain area of the domestic chick.
Topics: Acoustic Stimulation; Amino Acids; Animals; Auditory Perception; Behavior, Animal; Biogenic Monoamines; Chickens; Discrimination, Psychological; Extracellular Fluid; Female; Glutamic Acid; Haloperidol; Homovanillic Acid; Hydroxyindoleacetic Acid; Imprinting, Psychological; Male; Microdialysis; N-Methylaspartate; Prosencephalon; Synaptic Transmission; Taurine | 2003 |
Glutamatergic activation of the amygdala differentially mimics the effects of audiogenic seizure kindling in two substrains of genetically epilepsy-prone rats.
Topics: Acoustic Stimulation; Amygdala; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Reflex; Female; Genetic Predisposition to Disease; Glutamic Acid; Kindling, Neurologic; Male; Microinjections; N-Methylaspartate; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Seizures | 2003 |
Subunit-dependent effects of nickel on NMDA receptor channels.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Kidney; Membrane Potentials; N-Methylaspartate; Neural Conduction; Neural Inhibition; Neurons; Nickel; Patch-Clamp Techniques; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Transfection | 2003 |
Alteration of NMDA NR1 receptors within the paraventricular nucleus of hypothalamus in rats with heart failure.
Topics: Animals; Blood Pressure; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Failure; Heart Rate; Kidney; Male; Microdialysis; Microinjections; N-Methylaspartate; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sympathetic Nervous System | 2003 |
Distinct quantal features of AMPA and NMDA synaptic currents in hippocampal neurons: implication of glutamate spillover and receptor saturation.
Topics: Algorithms; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Dendrites; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Membrane Potentials; Models, Neurological; Models, Statistical; N-Methylaspartate; Pyramidal Cells; Quantum Theory; Rats; Rats, Wistar; Synaptic Transmission | 2003 |
Potentiation of NMDA receptor-mediated synaptic responses by microglia.
Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Cells, Cultured; Culture Media, Conditioned; Electric Stimulation; Encephalitis; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Microglia; Molecular Weight; N-Methylaspartate; Nerve Tissue Proteins; Organ Culture Techniques; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2003 |
Selegiline reduces N-methyl-D-aspartic acid induced perturbation of neurotransmission but it leaves NMDA receptor dependent long-term potentiation intact in the hippocampus.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Monoamine Oxidase Inhibitors; N-Methylaspartate; Neurons; Pargyline; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Selegiline; Synaptic Transmission | 2003 |
Effect of excess extracellular glutamate on dendrite growth from cerebral cortical neurons at 3 days in vitro: Involvement of NMDA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Axons; Blotting, Western; Cell Survival; Cells, Cultured; Cerebral Cortex; Dendrites; Embryo, Mammalian; Excitatory Amino Acid Agonists; Extracellular Fluid; Glutamic Acid; Immunohistochemistry; Mice; Mice, Inbred BALB C; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate | 2003 |
Neurons derived from embryonic stem (ES) cells resemble normal neurons in their vulnerability to excitotoxic death.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Cell Lineage; Cell Survival; Cells, Cultured; Coculture Techniques; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Glutamic Acid; Immunohistochemistry; Kainic Acid; Mice; N-Methylaspartate; Neuroglia; Neurons; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA; Stem Cells | 2003 |
Increased calcium influx through acetylcholine receptors in dunce neurons.
Topics: Acetylcholine; Analysis of Variance; Animals; Cadmium Chloride; Calcium; Cells, Cultured; Curare; Dopamine; Drosophila; Drug Interactions; Excitatory Amino Acid Agonists; Extracellular Space; Fura-2; Glutamic Acid; Mutation; N-Methylaspartate; Neurons; Nicotinic Antagonists; Potassium Chloride; Receptors, Cholinergic; Serotonin; Time Factors; Vasodilator Agents | 2004 |
Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation.
Topics: Animals; Choline; Choline Deficiency; Cues; Cyclic AMP Response Element-Binding Protein; Female; Glutamic Acid; Hippocampus; Humans; MAP Kinase Signaling System; Maze Learning; Memory Disorders; Mitogen-Activated Protein Kinases; N-Methylaspartate; Phosphorylation; Potassium; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Protein Processing, Post-Translational; Rats; Reaction Time; Spatial Behavior | 2004 |
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae.
Topics: Alanine; Animals; Biguanides; Calcium Channel Blockers; Cattle; D-Aspartic Acid; Diltiazem; Dizocilpine Maleate; Drug Synergism; Glucose; Glutamic Acid; Glycine; Humans; Kainic Acid; N-Methylaspartate; Nitrendipine; omega-Conotoxins; Perfusion; Piperidines; Polyamines; Receptors, Glutamate; Retina; Tritium; Verapamil | 2003 |
Assessment of neuronal maturation and acquisition of functional competence in the developing zebrafish olfactory system.
Topics: Agmatine; Amino Acids; Animals; Embryo, Nonmammalian; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Glutamic Acid; N-Methylaspartate; Olfactory Bulb; Olfactory Receptor Neurons; Receptors, Glutamate; Zebrafish | 2003 |
Hypoxia increases calcium flux through cortical neuron glutamate receptors via protein kinase C.
Topics: Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Calcium; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Immunohistochemistry; In Situ Hybridization; Mice; N-Methylaspartate; Neurons; Oxygen; Phenanthridines; Phosphorylation; Protein Kinase C; Receptors, Glutamate; Time Factors | 2004 |
Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Antagonism; Dynorphins; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Hyperalgesia; Injections, Spinal; Isoenzymes; Membrane Proteins; Microdialysis; N-Methylaspartate; Peptide Fragments; Prostaglandin-Endoperoxide Synthases; Rats; Spinal Cord | 2004 |
The blockade by phencyclidine of glutamate-induced intracellular calcium increase in cultured neocortical neurons.
Topics: Animals; Calcium; Cells, Cultured; Chelating Agents; Diagnostic Imaging; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescein; Glutamic Acid; Intracellular Space; Microscopy, Confocal; N-Methylaspartate; Neocortex; Neurons; Phencyclidine; Rats; Rats, Wistar | 2004 |
Effect of acute calcium influx after mechanical stretch injury in vitro on the viability of hippocampal neurons.
Topics: Animals; Calcium; Cell Death; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Stress, Mechanical | 2004 |
Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Cellular Senescence; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Eye Proteins; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Picrotoxin; Receptors, AMPA; Receptors, GABA; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Retina; Taurine | 2004 |
Cellular mechanisms of serotonin 5-HT2A receptor-mediated cGMP formation: the essential role of glutamate.
Topics: Animals; Brain; Cyclic GMP; Glutamic Acid; Male; N-Methylaspartate; PC12 Cells; Rats; Rats, Inbred F344; Receptor, Serotonin, 5-HT2A; Receptors, N-Methyl-D-Aspartate; Serotonin 5-HT2 Receptor Agonists; Serotonin Receptor Agonists | 2004 |
Role of Arg100 in the active site of adenosylcobalamin-dependent glutamate mutase.
Topics: Arginine; Bacterial Proteins; Binding Sites; Catalysis; Cobamides; Deuterium; Glutamic Acid; Hydrogen Bonding; Intramolecular Transferases; Kinetics; Lysine; Mutagenesis, Site-Directed; N-Methylaspartate; Spectrophotometry; Substrate Specificity; Vitamin B 12 | 2004 |
Neurotensin enhances endogenous extracellular glutamate levels in primary cultures of rat cortical neurons: involvement of neurotensin receptor in NMDA induced excitotoxicity.
Topics: Animals; Bisbenzimidazole; Calcium; Cells, Cultured; Cerebral Cortex; Chromatin; Coloring Agents; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; N-Methylaspartate; Naphthalenes; Neurons; Neurotensin; Neurotoxicity Syndromes; Peptide Fragments; Pyrazoles; Quinolines; Rats; Receptors, Neurotensin | 2004 |
Presynaptic NMDA receptors modulate glutamate release from primary sensory neurons in rat spinal cord dorsal horn.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Neurons, Afferent; Patch-Clamp Techniques; Posterior Horn Cells; Presynaptic Terminals; Rats; Receptors, N-Methyl-D-Aspartate | 2004 |
AMPA, not NMDA, activates RhoA GTPases and subsequently phosphorylates moesin.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Line; Excitatory Amino Acid Agonists; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Kainic Acid; Microfilament Proteins; N-Methylaspartate; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; rho-Associated Kinases; rhoA GTP-Binding Protein | 2004 |
Glutamate transporters prevent the generation of seizures in the developing rat neocortex.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Biological Clocks; Calcium Signaling; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Neocortex; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2004 |
Regulation of glutamate-synthesizing enzymes by NMDA and potassium in cerebellar granule cells.
Topics: Animals; Aspartate Aminotransferases; Cell Survival; Cells, Cultured; Cerebellum; Glutamic Acid; Glutaminase; N-Methylaspartate; Potassium Chloride; Rats | 2004 |
Extracellular taurine in the substantia nigra: taurine-glutamate interaction.
Topics: Adrenergic Agents; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain Chemistry; Calcium; Chelating Agents; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Excitatory Amino Acid Antagonists; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Ketamine; Male; Membrane Potentials; Microdialysis; N-Methylaspartate; Oxidopamine; Potassium; Rats; Rats, Sprague-Dawley; Substantia Nigra; Taurine; Time Factors; Zinc | 2004 |
AMPA receptor activation, but not the accumulation of endogenous extracellular glutamate, induces paralysis and motor neuron death in rat spinal cord in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Drug Administration Routes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Fluid; Glutamic Acid; Hindlimb; Kainic Acid; Lumbosacral Region; Male; Microdialysis; Motor Neurons; N-Methylaspartate; Paralysis; Perfusion; Potassium; Potassium Channel Blockers; Rats; Receptors, AMPA; Spinal Cord | 2004 |
Hypoxic/ischaemic cell damage in cultured human NT-2 neurons.
Topics: Aging; Calcimycin; Calcium; Cell Death; Cell Line, Tumor; Cell Survival; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescein; Glutamic Acid; Humans; Hypoxia; Ionophores; Mitochondria; N-Methylaspartate; Neurons; Teratocarcinoma; Time Factors | 2004 |
Elevation of intracellular cAMP evokes activity-dependent release of adenosine in cultured rat forebrain neurons.
Topics: Adenosine; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Cyclic AMP; Cyclic GMP; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Activation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Female; Glutamic Acid; Intracellular Space; Male; Membrane Potentials; Models, Neurological; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Pregnancy; Prosencephalon; Purinones; Rats; Rats, Sprague-Dawley; Thionucleotides | 2004 |
Rapid synaptic plasticity of glutamatergic synapses on dopamine neurons in the ventral tegmental area in response to acute amphetamine injection.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamine; Animals; Animals, Newborn; Behavior, Animal; Blotting, Western; Central Nervous System Stimulants; Dopamine; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; Motor Activity; N-Methylaspartate; Neuronal Plasticity; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Synapses; Time Factors; Transferrin; Ventral Tegmental Area | 2004 |
Protective cap over CA1 synapses: extrasynaptic glutamate does not reach the postsynaptic density.
Topics: 4-Aminopyridine; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Dizocilpine Maleate; Drug Interactions; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Models, Neurological; N-Methylaspartate; Neural Inhibition; Neurons; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Synapses | 2004 |
Inhibitory effects of angiotensin on NMDA-induced cytotoxicity in primary neuronal cultures.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Apoptosis; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Glutamic Acid; In Situ Nick-End Labeling; Losartan; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents | 2004 |
NMDA and AMPA receptors mediate intracellular calcium increase in rat cortical astrocytes.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Astrocytes; Calcium; Cells, Cultured; Cerebral Cortex; Glutamic Acid; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2004 |
Dopamine-glutamate interactions controlling prefrontal cortical pyramidal cell excitability involve multiple signaling mechanisms.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Agonists; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Male; N-Methylaspartate; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Dopamine D1; Receptors, Dopamine D2; Signal Transduction | 2004 |
Glutamate-induced elevations in intracellular chloride concentration in hippocampal cell cultures derived from EYFP-expressing mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Angiogenesis Inhibitors; Animals; Animals, Newborn; Bacterial Proteins; Benzopyrans; Bicuculline; Cells, Cultured; Chlorides; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Furosemide; GABA Antagonists; Glutamic Acid; Hippocampus; Hydrogen-Ion Concentration; Intracellular Space; Luminescent Proteins; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred Strains; Mice, Transgenic; N-Methylaspartate; Naphthols; Neurons; Nitrobenzoates; Potassium; Rhodamines; Time Factors | 2004 |
Neuroprotective effects of the mGlu5R antagonist MPEP towards quinolinic acid-induced striatal toxicity: involvement of pre- and post-synaptic mechanisms and lack of direct NMDA blocking activity.
Topics: Animals; Body Weight; Calcium; Cells, Cultured; Electroencephalography; Excitatory Amino Acid Antagonists; Glutamic Acid; L-Lactate Dehydrogenase; Male; Maze Learning; Microdialysis; N-Methylaspartate; Neostriatum; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Pyridines; Quinolinic Acid; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate | 2004 |
Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Non-Narcotic; Animals; Binding, Competitive; Electroshock; Epilepsy; Excitatory Amino Acid Agonists; Glutamic Acid; Ion Channel Gating; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Nefopam; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Sodium Channels; Synaptic Transmission; Tritium | 2004 |
Adenosine A2A receptor blockade differentially influences excitotoxic mechanisms at pre- and postsynaptic sites in the rat striatum.
Topics: 4-Aminopyridine; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Calcium; Corpus Striatum; Dose-Response Relationship, Drug; Glutamic Acid; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Models, Biological; N-Methylaspartate; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Phenethylamines; Pyrimidines; Quinolinic Acid; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Synaptic Transmission; Triazines; Triazoles | 2004 |
Glutamatergic synaptic transmission participates in generating the hippocampal EEG.
Topics: Animals; Cerebral Ventricles; Electroencephalography; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Injections, Intraventricular; Kinetics; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Long-Evans; Synaptic Transmission | 2004 |
Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Count; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Degeneration; Retinal Ganglion Cells; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Thy-1 Antigens; Up-Regulation | 2004 |
Tetanization-induced pelvic-to-pudendal reflex plasticity in anesthetized rats.
Topics: Animals; Bicuculline; Decerebrate State; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; GABA-A Receptor Antagonists; Glutamic Acid; Long-Term Potentiation; N-Methylaspartate; Nervous System Physiological Phenomena; Neuronal Plasticity; Pelvis; Quinoxalines; Rats; Rats, Wistar; Reflex; Valine | 2004 |
Invulnerability of retinal ganglion cells to NMDA excitotoxicity.
Topics: Amacrine Cells; Animals; Animals, Newborn; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Drug Resistance; Fluorescent Dyes; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate; Retinal Degeneration; Retinal Ganglion Cells; Stilbamidines; Synaptic Transmission | 2004 |
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Phenols; Picrotoxin; Piperidines; Protein Subunits; Pyrrolidines; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2004 |
The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.
Topics: 2-Amino-5-phosphonovalerate; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Ibotenic Acid; Kainic Acid; Ligands; Membrane Potentials; Models, Molecular; N-Methylaspartate; Pyrazoles; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Thermodynamics; Tritium | 2004 |
Group B vitamins protect murine cerebellar granule cells from glutamate/NMDA toxicity.
Topics: Animals; Cell Death; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Glutamic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Neuroprotective Agents; Riboflavin; Vitamin B 12; Vitamin B Complex | 2004 |
A role for L-glutamate ionotropic receptors in the development of rat neurogenic pulmonary edema.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Blood Pressure; Blood Proteins; Body Fluids; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fibrin; Fourth Ventricle; Glutamic Acid; Heart Rate; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Proteins; Pulmonary Edema; Rats; Rats, Wistar; Receptors, Glutamate; Vagus Nerve | 2004 |
Effect of the exogenous glutamate and the NMDA on electric field-stimulated contractions of isolated rat ileum.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; Glutamic Acid; Ileum; In Vitro Techniques; Male; Muscle Contraction; N-Methylaspartate; Rats; Rats, Wistar | 2004 |
Polygalae radix extract protects cultured rat granule cells against damage induced by NMDA.
Topics: Animals; Calcium; Cell Survival; Cerebellum; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glutamic Acid; N-Methylaspartate; Neurons; Plant Preparations; Polygalaceae; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2004 |
Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Amino Acids; Animals; Aspartic Acid; Dicarboxylic Acids; Drug Interactions; Entorhinal Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; In Vitro Techniques; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission; Xanthenes | 2004 |
Understanding neurochemical changes during retinal diseases.
Topics: Animals; Betaxolol; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; N-Methylaspartate; Neurons; Retina; Retinal Diseases | 2004 |
Quantification of amino acid neurochemistry secondary to NMDA or betaxolol application.
Topics: Adrenergic beta-Antagonists; Agmatine; Amacrine Cells; Animals; Betaxolol; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Immunohistochemistry; N-Methylaspartate; Neurons; Rabbits; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells | 2004 |
Distinct modulatory roles of sigma receptor subtypes on glutamatergic responses in the dorsal hippocampus.
Topics: Action Potentials; Analysis of Variance; Animals; Anisoles; Antipsychotic Agents; Benzamides; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Male; N-Methylaspartate; Piperidines; Propylamines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, sigma | 2005 |
Protective effect of DY-9760e, a calmodulin antagonist, against neuronal cell death.
Topics: Animals; Calcium; Calcium Channels; Calcium-Transporting ATPases; Calmodulin; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Glutamic Acid; Indazoles; Ion Channel Gating; N-Methylaspartate; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Potassium Chloride; Rats; Sodium Channels; Thapsigargin; Veratridine | 2004 |
Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microdialysis; N-Methylaspartate; Nucleus Accumbens; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Synaptic Transmission; Theophylline | 2004 |
Glutamate-evoked alterations of glial and neuronal cell morphology in the guinea pig retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Cell Size; Circadian Rhythm; Cytochalasin D; Cytoskeleton; Dicarboxylic Acids; Dopamine; Eye Proteins; Glutamic Acid; Guinea Pigs; Ischemia; Kainic Acid; N-Methylaspartate; Neuroglia; Neurons; Nocodazole; Potassium; Pyrrolidines; Receptors, AMPA; Receptors, Kainic Acid; Retina; Retinal Ganglion Cells; Synaptic Transmission; Xanthenes | 2004 |
Putative NMDA receptors in Hydra: a biochemical and functional study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Binding Sites; Cell Membrane; Concanavalin A; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Feeding Behavior; Glutamic Acid; Glutathione; Glycine; Hydra; Kynurenic Acid; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine; Strychnine | 2004 |
Susceptibilities to and mechanisms of excitotoxic cell death of adult mouse inner retinal neurons in dissociated culture.
Topics: Amacrine Cells; Animals; Calcium; Cell Survival; Cells, Cultured; Drug Resistance; Excitatory Amino Acid Agonists; Glutamic Acid; Immunohistochemistry; Kainic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Neurotoxins; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Sodium; Sodium-Calcium Exchanger | 2004 |
Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways.
Topics: Activating Transcription Factor 2; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Calcium; Cell Count; Cell Survival; Cells, Cultured; Cerebellum; Chromatin; Cyclic AMP Response Element-Binding Protein; Dizocilpine Maleate; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Glutamic Acid; Humans; Membrane Potentials; Microscopy, Confocal; Minocycline; N-Methylaspartate; Neurons; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Patch-Clamp Techniques; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Serine; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors; Transcription Factors | 2004 |
Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death.
Topics: Active Transport, Cell Nucleus; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Apoptosis Inducing Factor; Caspases; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Cysteine Proteinase Inhibitors; Cytochromes c; DNA Damage; Enzyme Activation; Excitatory Amino Acid Agonists; Flavoproteins; Genes, bcl-2; Glutamic Acid; Injections; Intracellular Membranes; Membrane Potentials; Membrane Proteins; Mice; Mice, Knockout; Mitochondria; N-Methylaspartate; Neurons; Nitric Oxide; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Transfection | 2004 |
NMDA receptor-mediated calcium influx plays an essential role in myoblast fusion.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adaptor Proteins, Signal Transducing; Animals; Calcimycin; Calcium; Carrier Proteins; Cell Differentiation; Cell Fusion; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ionophores; Mice; Myoblasts, Skeletal; N-Methylaspartate; Nerve Tissue Proteins; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Thapsigargin | 2004 |
Synaptogenesis and amino acid release from long term embryonic rat spinal cord neuronal culture using tissue culture inserts.
Topics: Animals; Biomarkers; Cell Differentiation; Cells, Cultured; Diffusion Chambers, Culture; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Glutamic Acid; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Neurotransmitter Agents; Perfusion; Phenotype; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synapses; Synaptic Transmission; Tissue Culture Techniques | 2005 |
Nitric oxide modulation of glutamatergic, baroreflex, and cardiopulmonary transmission in the nucleus of the solitary tract.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Baroreflex; Biguanides; Blood Pressure; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Heart; Heart Rate; Kidney; Lung; Male; Microinjections; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Pressoreceptors; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Sympathetic Nervous System; Synaptic Transmission | 2005 |
Neural segregation of Fos-protein distribution in the brain following freezing and escape behaviors induced by injections of either glutamate or NMDA into the dorsal periaqueductal gray of rats.
Topics: Amygdala; Animals; Dose-Response Relationship, Drug; Escape Reaction; Freezing Reaction, Cataleptic; Glutamic Acid; Hypothalamus; Male; Microinjections; Motor Activity; N-Methylaspartate; Neural Pathways; Neurons; Perception; Periaqueductal Gray; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Glutamate; Reticular Formation; Stimulation, Chemical; Tissue Distribution | 2005 |
Glutamate agonists activate the hypothalamic-pituitary-adrenal axis through hypothalamic paraventricular nucleus but not through vasopressinerg neurons.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Arginine Vasopressin; Corticosterone; Excitatory Amino Acid Agonists; Glutamic Acid; Hypothalamo-Hypophyseal System; Injections, Intravenous; Kainic Acid; Male; N-Methylaspartate; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Rats; Rats, Brattleboro; Rats, Wistar; Species Specificity | 2005 |
Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Apoptosis Inducing Factor; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; Benzodiazepines; Benzothiadiazines; Camptothecin; Caspase Inhibitors; Cells, Cultured; Cerebellum; Cerebral Cortex; Convulsants; Dizocilpine Maleate; Drug Resistance; Flavoproteins; Glutamic Acid; Glycine; Hippocampus; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Knockout; Mice, Mutant Strains; N-Methylaspartate; Neurons; Neurotoxins; Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Seizures | 2005 |
Effects of N-methyl-d-aspartate, glutamate, and glycine on the dorsal column axons of neonatal rat spinal cord: in vitro study.
Topics: Age Factors; Animals; Animals, Newborn; Axons; Cell Culture Techniques; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; N-Methylaspartate; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2005 |
P2 receptor antagonist PPADS confers neuroprotection against glutamate/NMDA toxicity.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Glutamic Acid; Mice; N-Methylaspartate; Neuroprotective Agents; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Receptors, Purinergic P2 | 2005 |
Membrane potential oscillations in reticulospinal and spinobulbar neurons during locomotor activity.
Topics: Analysis of Variance; Animals; Calcium; Electric Stimulation; Functional Laterality; Glutamic Acid; In Vitro Techniques; Lampreys; Magnesium; Membrane Potentials; Motor Activity; N-Methylaspartate; Neural Conduction; Neural Pathways; Neurons; Periodicity; Spinal Cord; Synaptic Transmission | 2005 |
N-methyl-D-aspartate and TrkB receptors protect neurons against glutamate excitotoxicity through an extracellular signal-regulated kinase pathway.
Topics: Animals; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Butadienes; Carbazoles; Chromones; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Glutamic Acid; Indole Alkaloids; Mitogen-Activated Protein Kinase Kinases; Morpholines; N-Methylaspartate; Neurons; Neuroprotective Agents; Nitriles; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptor, trkB; RNA, Messenger; Signal Transduction | 2005 |
Protection by cholesterol-extracting cyclodextrins: a role for N-methyl-D-aspartate receptor redistribution.
Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Cholesterol; Cyclodextrins; Cytoprotection; Disks Large Homolog 4 Protein; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia-Ischemia, Brain; Intracellular Signaling Peptides and Proteins; Membrane Microdomains; Membrane Proteins; Methylation; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Neurotoxins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Receptor Aggregation; Receptors, N-Methyl-D-Aspartate; Sulfur Compounds; Synaptic Transmission | 2005 |
Effect of glutamate and somatostatin-14 on basal and cAMP-stimulated steroidogenesis by rainbow trout (Oncorhynchus mykiss) ovarian follicles, in vitro.
Topics: Animals; Cyclic AMP; Estradiol; Female; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Oncorhynchus mykiss; Ovarian Follicle; Pregnenolone; Somatostatin; Steroids; Testosterone | 2005 |
Striatal glutamate release evoked in vivo by NMDA is dependent upon ongoing neuronal activity in the substantia nigra, endogenous striatal substance P and dopamine.
Topics: Adrenergic Agents; Animals; Benzazepines; Bicuculline; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; Glutamic Acid; Magnesium; Male; N-Methylaspartate; Neurons; Oxidopamine; Piperidines; Potassium Chloride; Quinuclidines; Raclopride; Rats; Rats, Sprague-Dawley; Substance P; Substantia Nigra; Tetrodotoxin; Time Factors | 2005 |
Morphine causes a delayed increase in glutamate receptor functioning in the nucleus accumbens core.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; gamma-Aminobutyric Acid; Glutamic Acid; Injections, Subcutaneous; Male; Morphine; N-Methylaspartate; Nucleus Accumbens; Potassium; Rats; Rats, Wistar; Receptors, Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription, Genetic; Tritium | 2005 |
Activation of dopaminergic neurotransmission in the medial prefrontal cortex by N-methyl-d-aspartate stimulation of the ventral hippocampus in rats.
Topics: Animals; Dopamine; Excitatory Amino Acid Agonists; Extracellular Fluid; Glutamic Acid; Hippocampus; Hyperkinesis; Male; Microdialysis; N-Methylaspartate; Neural Pathways; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Ventral Tegmental Area | 2005 |
Visualization of synaptic Ca2+ /calmodulin-dependent protein kinase II activity in living neurons.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Benzylamines; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Line; Diagnostic Imaging; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fluorescence Resonance Energy Transfer; Gene Expression; Glutamic Acid; Glycine; Hippocampus; Humans; Insecta; Luminescent Proteins; Microscopy, Confocal; Molecular Biology; Mutagenesis, Site-Directed; N-Methylaspartate; Neurons; Phosphorylation; Protein Binding; Quinoxalines; Sodium Channel Blockers; Sulfonamides; Synapses; Tetrodotoxin; Time Factors; Transfection | 2005 |
Regulation of N-methyl-D-aspartate receptors by calpain in cortical neurons.
Topics: Animals; Blotting, Western; Calcium; Calpain; Down-Regulation; Dynamins; Endocytosis; Enzyme Inhibitors; Glutamic Acid; Immunoblotting; Ischemia; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Peptides; Rats; Receptors, N-Methyl-D-Aspartate; Time Factors | 2005 |
Glutamate antagonists attenuate the action of NC-1900, a vasopressin fragment analog, on passive avoidance task performance in mice.
Topics: Animals; Avoidance Learning; Benzoates; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Memory; Mice; N-Methylaspartate; Oligopeptides; Pyrrolidonecarboxylic Acid; Receptors, Glutamate; Vasopressins | 2005 |
Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Etoposide; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Hydrolysis; Male; Membrane Potentials; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Neuroprotective Agents; Phenylacetates; Phosphatidylinositols; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Thiazoles | 2005 |
Glutamate induces the rapid formation of spine head protrusions in hippocampal slice cultures.
Topics: Animals; Dendrites; Glutamic Acid; Hippocampus; Image Processing, Computer-Assisted; Kinetics; Mice; N-Methylaspartate; Organ Culture Techniques; Pyramidal Cells; Quinoxalines; Tetrodotoxin | 2005 |
Adenosine mediation of presynaptic feedback inhibition of glutamate release.
Topics: Adenosine; Anesthetics, Local; Animals; Brain Stem; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Feedback, Physiological; Glutamic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 2005 |
Supraspinal and spinal alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid and N-methyl-D-aspartate glutamatergic control of the micturition reflex in the urethane-anesthetized rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Anesthetics, Intravenous; Animals; Brain; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electromyography; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Injections, Intraventricular; Injections, Spinal; Isoquinolines; N-Methylaspartate; Neural Pathways; Rats; Rats, Sprague-Dawley; Spinal Cord; Tetrazoles; Urethane; Urinary Bladder; Urination | 2005 |
Release of arginine, glutamate and glutamine in the hippocampus of freely moving rats: Involvement of nitric oxide.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arginine; Behavior, Animal; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Glutamine; Hippocampus; Indazoles; Male; Microdialysis; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Wistar; Wakefulness | 2005 |
A noncanonical release of GABA and glutamate modulates neuronal migration.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Bicuculline; Bromodeoxyuridine; Cell Movement; Dideoxynucleosides; Dizocilpine Maleate; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Immunohistochemistry; In Vitro Techniques; Mice; Mice, Mutant Strains; Mice, Transgenic; Microtubule-Associated Proteins; Munc18 Proteins; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 2005 |
Protein retention in the endoplasmic reticulum, blockade of programmed cell death and autophagy selectively occur in spinal cord motoneurons after glutamate receptor-mediated injury.
Topics: Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Apoptosis; Autophagy; Axotomy; Chick Embryo; Disease Models, Animal; Endoplasmic Reticulum; Excitatory Amino Acid Agonists; Glutamic Acid; Inclusion Bodies; Microscopy, Electron, Transmission; Models, Neurological; N-Methylaspartate; Nerve Tissue Proteins; Neurofilament Proteins; Neurotoxins; Protein Biosynthesis; Receptors, Glutamate; Stress, Physiological | 2005 |
Glutamate transporter type 3 attenuates the activation of N-methyl-D-aspartate receptors co-expressed in Xenopus oocytes.
Topics: Amino Acid Transport System X-AG; Animals; Gene Expression; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glycine; Membrane Potentials; N-Methylaspartate; Oocytes; Receptors, N-Methyl-D-Aspartate; Symporters; Xenopus laevis | 2005 |
Long-term potentiation of silent synapses in substantia gelatinosa neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Chelating Agents; Dose-Response Relationship, Radiation; Drug Interactions; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Long-Term Potentiation; Magnesium; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Substantia Gelatinosa; Synapses | 2005 |
Binding of C5-dicarboxylic substrate to aspartate aminotransferase: implications for the conformational change at the transaldimination step.
Topics: Amines; Amino Acids, Dicarboxylic; Aspartate Aminotransferases; Aspartic Acid; Binding Sites; Crystallography, X-Ray; Escherichia coli Proteins; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Imines; Ligands; Models, Chemical; N-Methylaspartate; Protein Conformation; Substrate Specificity | 2005 |
Negative regulation of neurotransmitter release by calpain: a possible involvement of specific SNAP-25 cleavage.
Topics: Age Factors; Animals; Animals, Newborn; Antibodies; Blotting, Western; Calcium; Calpain; Cells, Cultured; Cerebellum; Chromatography, High Pressure Liquid; Dipeptides; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Glycoproteins; Ionomycin; Ionophores; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Potassium; Rats; Rats, Wistar; Synaptosomal-Associated Protein 25; Time Factors | 2005 |
Adenosine receptors co-operate with NMDA preconditioning to protect cerebellar granule cells against glutamate neurotoxicity.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Animals; Animals, Newborn; Cell Death; Cells, Cultured; Cerebellum; Cyclic AMP; Drug Antagonism; Excitatory Amino Acid Agonists; Glutamic Acid; Hydrolysis; N-Methylaspartate; Neurons; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles | 2005 |
Dopaminergic neurotoxins require excitotoxic stimulation in organotypic cultures.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Brain; Cell Death; Cell Nucleus; Cerebral Cortex; Corpus Striatum; Dopamine; Drug Synergism; Glutamic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Organ Culture Techniques; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Tyrosine 3-Monooxygenase | 2005 |
The excitoprotective effect of N-methyl-D-aspartate receptors is mediated by a brain-derived neurotrophic factor autocrine loop in cultured hippocampal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Age Factors; Animals; Antibodies; Autocrine Communication; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Time Factors; Tyrosine | 2005 |
Functional assessment of glutamate clearance mechanisms in a chronic rat glaucoma model using retinal ganglion cell calcium imaging.
Topics: Animals; Animals, Newborn; Aspartic Acid; Calcium; Cells, Cultured; Diagnostic Imaging; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Fura-2; Glaucoma; Glutamic Acid; In Vitro Techniques; Intraocular Pressure; Male; N-Methylaspartate; Optic Nerve; Rats; Rats, Long-Evans; Retina; Retinal Ganglion Cells; Time Factors | 2005 |
NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin.
Topics: Animals; Autoradiography; Brain; Calcineurin; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Glutathione Transferase; Hydroxylation; Immunoblotting; Immunoprecipitation; Membrane Potentials; Methoxyhydroxyphenylglycol; Mutagenesis; N-Methylaspartate; Okadaic Acid; Oocytes; Patch-Clamp Techniques; Phosphatidylinositols; Protein Kinase C; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Transfection; Xenopus | 2005 |
Physiological role for casein kinase 1 in glutamatergic synaptic transmission.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Casein Kinase 1 epsilon; Casein Kinase I; Casein Kinase Ialpha; Casein Kinase Idelta; Corpus Striatum; Egtazic Acid; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Kainic Acid; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neocortex; Nerve Tissue Proteins; Okadaic Acid; Phosphoprotein Phosphatases; Protein Phosphatase 1; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tetrodotoxin | 2005 |
Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Blotting, Western; Cell Death; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Gene Expression Regulation, Developmental; Glutamic Acid; Heptanes; Heterocyclic Compounds, 3-Ring; Hippocampus; Homeostasis; Humans; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Time Factors; Tritium | 2005 |
Functional interconnectivity between the globus pallidus and the subthalamic nucleus in the mouse brain slice.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Apamin; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; In Vitro Techniques; Lysine; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Nerve Net; Neurons; Picrotoxin; Subthalamic Nucleus | 2005 |
Involvement of NMDA receptors in the hypotensive response to the injection of L-glutamate into the lateral hypothalamus of unanesthetized rats.
Topics: Analysis of Variance; Animals; Blood Pressure; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Heart Rate; Hypertension; Hypothalamic Area, Lateral; Male; Microinjections; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Wakefulness | 2005 |
Inhibition of rho-kinase in the nucleus tractus solitarius enhances glutamate sensitivity in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amides; Animals; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; In Vitro Techniques; Injections; Intracellular Signaling Peptides and Proteins; Iontophoresis; Male; N-Methylaspartate; Neurons; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; Solitary Nucleus | 2005 |
Isoflurane preconditioning decreases glutamate receptor overactivation-induced Purkinje neuronal injury in rat cerebellar slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Inhalation; Animals; Cell Survival; Cerebellum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Isoflurane; Male; N-Methylaspartate; Pertussis Toxin; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 2005 |
Release kinetics, quantal parameters and their modulation during short-term depression at a developing synapse in the rat CNS.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Brain Stem; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Kinetics; N-Methylaspartate; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Synaptic Vesicles | 2005 |
Inhibitory glutamate receptors in spider peripheral mechanosensory neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; beta-Alanine; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Excitatory Amino Acid Agonists; GABA Agonists; Glutamic Acid; In Vitro Techniques; Mechanoreceptors; Membrane Potentials; Muscimol; N-Methylaspartate; Neural Inhibition; Neurons, Afferent; Physical Stimulation; Receptors, Glutamate; Sense Organs; Spiders | 2005 |
Dual Ca2+ modulation of glycinergic synaptic currents in rodent hypoglossal motoneurones.
Topics: Animals; Benzoxazines; Calcium; Cannabinoid Receptor Modulators; Glutamic Acid; Glycine; Hypoglossal Nerve; In Vitro Techniques; Membrane Potentials; Mice; Morpholines; Motor Neurons; N-Methylaspartate; Naphthalenes; Neural Inhibition; Piperidines; Presynaptic Terminals; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Cannabinoid; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Rimonabant; Synaptic Transmission | 2005 |
Neurochemical evidence to implicate elevated glutamate in the mechanisms of high intraocular pressure (IOP)-induced retinal ganglion cell death in rat.
Topics: Animals; Apoptosis; Cell Death; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Intraocular Pressure; Male; Microdialysis; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Ocular Hypertension; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Retinal Ganglion Cells | 2005 |
Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bradykinin; Drug Synergism; Glutamic Acid; Hyperalgesia; In Vitro Techniques; Mice; Mice, Knockout; N-Methylaspartate; Pain; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B2; Spinal Cord; Synaptic Transmission | 2005 |
Differential effects of constant light on circadian clock resetting by photic and nonphotic stimuli in Syrian hamsters.
Topics: Animals; Biological Clocks; Circadian Rhythm; Cricetinae; Excitatory Amino Acid Agonists; Glutamic Acid; Light; Male; Mesocricetus; N-Methylaspartate; Photic Stimulation; Suprachiasmatic Nucleus; Synaptic Transmission; Visual Pathways | 2005 |
Rapid control of brain aromatase activity by glutamatergic inputs.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aromatase; Brain; Coturnix; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate | 2006 |
Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia.
Topics: Animals; Brain Infarction; Brain Ischemia; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; Glutamic Acid; Guanidines; Mice; N-Methylaspartate; Neurons; Reperfusion; Sodium-Hydrogen Exchangers; Tetrazolium Salts; Thiazoles | 2005 |
Neuroprotective effect of Chuk-Me-Sun-Dan on NMDA- and AMPA-evoked nitric oxide synthase activity in mouse brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Mice; N-Methylaspartate; Neuroprotective Agents; Nitric Oxide Synthase; Plant Extracts; Receptors, Glutamate | 2005 |
Anatomical evidence for glutamatergic transmission in primary sensory neurons and onto postganglionic neurons controlling penile erection in rats: an ultrastructural study with neuronal tracing and immunocytochemistry.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ganglia, Spinal; Glutamic Acid; Immunohistochemistry; Lumbosacral Region; Male; Microscopy, Electron, Transmission; N-Methylaspartate; Nerve Fibers; Neurons, Afferent; Penile Erection; Penis; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission | 2006 |
Glutamatergic neurotransmission expression profiling in the mouse hippocampus after perforant-path transection.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; DNA, Complementary; Down-Regulation; Gene Expression Profiling; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Immunoblotting; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nucleic Acid Amplification Techniques; Oligonucleotide Array Sequence Analysis; Perforant Pathway; Synaptic Transmission | 2005 |
Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses.
Topics: Amyloid beta-Peptides; Animals; Calcium; Cell Membrane; Cells, Cultured; Cyclin-Dependent Kinase 5; Disks Large Homolog 4 Protein; Down-Regulation; Frontal Lobe; Glutamic Acid; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Peptide Fragments; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Solubility; Synapses | 2005 |
Na+ channel-mediated Ca2+ entry leads to glutamate secretion in mouse neocortical preplate.
Topics: Animals; Aspartic Acid; Brain; Calcium; Exocytosis; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Mice; Mice, Inbred C57BL; Models, Biological; N-Methylaspartate; Neocortex; Neurons; Receptors, AMPA; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sodium; Sodium Channels; Software; Taurine; Time Factors; Veratridine | 2005 |
Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Binding Sites; Brain; Calcium; Cerebellum; Dendrites; Dose-Response Relationship, Drug; Electrophysiology; Glutamic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron; Motor Activity; N-Methylaspartate; Neurons; Polyvinyls; Presynaptic Terminals; Purkinje Cells; Quinoxalines; Rats; Receptors, AMPA; Sodium; Synapses; Tetrodotoxin; Time Factors | 2005 |
Changing the specificity of a bacterial chemoreceptor.
Topics: Amino Acid Sequence; Aspartic Acid; Bacterial Proteins; Chemoreceptor Cells; Chemotaxis; Culture Media; Cysteic Acid; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Membrane Proteins; Methyl-Accepting Chemotaxis Proteins; Molecular Sequence Data; N-Methylaspartate; Phenylalanine; Receptors, Amino Acid; Receptors, Cell Surface; Sequence Alignment | 2006 |
Zinc modulates primary afferent fiber-evoked responses of ventral roots in neonatal rat spinal cord in vitro.
Topics: Animals; Animals, Newborn; Bicuculline; Excitatory Amino Acid Agonists; GABA Antagonists; Glutamic Acid; Glycine Agents; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Nerve Fibers; Neurons, Afferent; Purinergic P2 Receptor Antagonists; Rats; Receptors, N-Methyl-D-Aspartate; Reflex; Spinal Cord; Spinal Nerve Roots; Strychnine; Substance P; Zinc | 2006 |
N-methyl-D-aspartate and group I metabotropic glutamate receptors are involved in the expression of ethanol-induced sensitization in mice.
Topics: Acamprosate; Alcoholism; Animals; Brain; Cyclopentanes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Glutamic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Pyridines; Quinolines; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior; Synaptic Transmission; Taurine; Thiazoles | 2006 |
Novel blockade of protein kinase A-mediated phosphorylation of AMPA receptors.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic beta-Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Calcineurin Inhibitors; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclosporine; Egtazic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gs; Hippocampus; Isoproterenol; Long-Term Potentiation; Male; Marine Toxins; Mice; Mice, Inbred C57BL; N-Methylaspartate; Oxazoles; Phenols; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Piperidines; Protein Phosphatase 1; Protein Phosphatase 2; Protein Processing, Post-Translational; Receptors, Adrenergic, beta-1; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2006 |
Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Substitution; Animals; Binding Sites; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Green Fluorescent Proteins; Hippocampus; Humans; Ionomycin; Kidney; Models, Molecular; Mutation, Missense; N-Methylaspartate; Neuronal Plasticity; Phosphorylation; Point Mutation; Protein Binding; Protein Conformation; Protein Interaction Mapping; Protein Isoforms; Protein Processing, Post-Translational; Protein Transport; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Synapses; Transfection | 2006 |
AMPA receptor-induced intracellular calcium response in the paraventricular nucleus is modulated by nitric oxide: calcium imaging in a hypothalamic organotypic cell culture model.
Topics: Adenosine Triphosphate; Aniline Compounds; Animals; Calcium; Cell Culture Techniques; Glutamic Acid; Histocytochemistry; Models, Biological; N-Methylaspartate; NADPH Dehydrogenase; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Paraventricular Hypothalamic Nucleus; Potassium; Rats; Receptors, AMPA; Staining and Labeling; Xanthenes | 2006 |
Peroxisome-proliferator-activated receptor-gamma (PPARgamma) activation protects neurons from NMDA excitotoxicity.
Topics: Analysis of Variance; Animals; Antibodies; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Diagnostic Imaging; Dizocilpine Maleate; Drug Interactions; Electrophoretic Mobility Shift Assay; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hydro-Lyases; Immunohistochemistry; Male; Microtubule-Associated Proteins; N-Methylaspartate; Neurons; Neuroprotective Agents; PPAR gamma; Propidium; Rats; Rats, Sprague-Dawley | 2006 |
Kynurenic acid synthesis in bovine retinal slices--effect of glutamate agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cattle; Excitatory Amino Acid Agonists; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Organ Culture Techniques; Retina | 2006 |
Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Diagnostic Imaging; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Isoquinolines; Mice; Microscopy, Video; N-Methylaspartate; Neurons; Neurotransmitter Agents; Patch-Clamp Techniques; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Signal Transduction; Sulfonamides; Suprachiasmatic Nucleus | 2006 |
Nickel differentially affects NMDA receptor channels in developing cultured rat neurons.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cells, Cultured; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Agonists; Glutamic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Nickel; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors; Trace Elements | 2006 |
Sodium- and magnesium-valproate in vivo modulate glutamatergic and GABAergic synapses in the medial prefrontal cortex.
Topics: Action Potentials; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Prefrontal Cortex; Quisqualic Acid; Rats; Rats, Wistar; Salts; Sodium; Synapses; Valproic Acid | 2006 |
Potentiation of the NMDA receptor-mediated responses through the activation of the glycine site by microglia secreting soluble factors.
Topics: Animals; Animals, Newborn; Cell Communication; Cells, Cultured; Culture Media, Conditioned; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Microglia; N-Methylaspartate; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission | 2006 |
Membrane channel properties of premotor excitatory burst neurons may underlie saccade slowing after lesions of omnipause neurons.
Topics: Action Potentials; Animals; Brain Stem; Computer Simulation; Functional Laterality; Glutamic Acid; Glycine; Ion Channels; Models, Neurological; N-Methylaspartate; Nerve Net; Neurons; Saccades | 2006 |
The neuroactive steroid pregnenolone sulfate stimulates the release of gonadotropin-releasing hormone from GT1-7 hypothalamic neurons, through N-methyl-D-aspartate receptors.
Topics: Animals; Cells, Cultured; Glutamic Acid; Glycine; Gonadotropin-Releasing Hormone; Hypothalamus; Mice; N-Methylaspartate; Pregnenolone; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Vesicular Glutamate Transport Protein 2 | 2006 |
Rapid hypoxia preconditioning protects cortical neurons from glutamate toxicity through delta-opioid receptor.
Topics: Animals; Cells, Cultured; Cellular Senescence; Cerebral Cortex; Enkephalin, Leucine-2-Alanine; Glutamic Acid; Hypoxia; Ischemic Preconditioning; L-Lactate Dehydrogenase; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Neurons; Rats; Receptors, Opioid, delta; RNA, Messenger; Time Factors; Up-Regulation | 2006 |
Neuroprotective role of neurokinin B (NKB) on beta-amyloid (25-35) induced toxicity in aging rat brain synaptosomes: involvement in oxidative stress and excitotoxicity.
Topics: Aging; Amyloid beta-Peptides; Animals; Brain; Calcium Signaling; Drug Interactions; Female; Free Radical Scavengers; Glutamic Acid; In Vitro Techniques; Monoamine Oxidase; N-Methylaspartate; Neurokinin B; Neuroprotective Agents; Neurotransmitter Agents; Oxidative Stress; Peptide Fragments; Rats; Rats, Wistar; Superoxide Dismutase; Synaptosomes | 2006 |
NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes.
Topics: Animals; Aspartic Acid; Astrocytes; Cerebral Cortex; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Green Fluorescent Proteins; Humans; Membrane Potentials; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Peptides, Cyclic; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2006 |
Estrogen modulates the spinal N-methyl-D-aspartic acid-mediated pelvic nerve-to-urethra reflex plasticity in rats.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Estrogens; Female; Glutamic Acid; N-Methylaspartate; Neuronal Plasticity; Pelvis; Quinoxalines; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord; Urethra | 2006 |
Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons.
Topics: Agmatine; Analysis of Variance; Animals; Cell Count; Cell Death; Cells, Cultured; Dizocilpine Maleate; Docosahexaenoic Acids; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Rats; Tubulin | 2006 |
Effects of NMDA receptor inhibition by phencyclidine on the neuronal differentiation of PC12 cells.
Topics: Analysis of Variance; Animals; Biogenic Amines; Blotting, Western; Cell Differentiation; Cell Survival; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Nerve Growth Factor; Neurites; Neurons; PC12 Cells; Phencyclidine; Protein Binding; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 2006 |
C-type natriuretic peptide modulates glutamate receptors on cultured rat retinal amacrine cells.
Topics: Amacrine Cells; Animals; Animals, Newborn; Benzodiazepines; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Immunohistochemistry; Isoenzymes; Membrane Potentials; N-Methylaspartate; Natriuretic Agents; Natriuretic Peptide, C-Type; Patch-Clamp Techniques; Polysaccharides; Rats; Receptors, Glutamate; Retina; Syntaxin 1 | 2006 |
Activation of 5-lipoxygenase after oxygen-glucose deprivation is partly mediated via NMDA receptor in rat cortical neurons.
Topics: Active Transport, Cell Nucleus; Animals; Animals, Newborn; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Encephalitis; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Hypoxia-Ischemia, Brain; Leukotrienes; N-Methylaspartate; Neurons; Oxygen; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2006 |
Selective inhibition of spontaneous but not Ca2+ -dependent release machinery by presynaptic group II mGluRs in rat cerebellar slices.
Topics: Action Potentials; Animals; Cadmium; Calcium; Calcium Channels; Cerebellum; Colforsin; Cyclopropanes; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Interneurons; N-Methylaspartate; Nickel; Patch-Clamp Techniques; Presynaptic Terminals; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Vesicles | 2006 |
GDNF abates serum deprivation-induced tyrosine hydroxylase Ser19 phosphorylation and activity.
Topics: Analysis of Variance; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Cells, Cultured; Culture Media, Serum-Free; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Gene Expression Regulation, Neoplastic; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Humans; Mesencephalon; N-Methylaspartate; Neuroblastoma; Neurons; Phosphorylation; Rats; Serine; Time Factors; Tyrosine 3-Monooxygenase | 2006 |
Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage.
Topics: Animals; Antioxidants; Biphenyl Compounds; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Hydrogen Peroxide; L-Lactate Dehydrogenase; Lignans; Mitochondria; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vitamin E | 2006 |
Iptakalim inhibits nicotinic acetylcholine receptor-mediated currents in dopamine neurons acutely dissociated from rat substantia nigra pars compacta.
Topics: Acetylcholine; Action Potentials; Animals; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Propylamines; Rats; Rats, Wistar; Receptors, Nicotinic; Substantia Nigra | 2006 |
Low cerebrospinal fluid glutamate and glycine in refractory affective disorder.
Topics: Adult; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Chromatography, High Pressure Liquid; Depressive Disorder, Major; Drug Resistance; Electroconvulsive Therapy; Female; Glutamic Acid; Glycine; Humans; Male; Middle Aged; N-Methylaspartate; Statistics as Topic | 2007 |
Synaptic GABAergic and glutamatergic mechanisms underlying alcohol sensitivity in mouse hippocampal neurons.
Topics: Animals; Benzylamines; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Phosphinic Acids; Receptors, GABA-A; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate; Sleep; Synaptic Transmission | 2006 |
Contribution of spinal glutamatergic receptors to the antinociception caused by agmatine in mice.
Topics: Agmatine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Neuroprotective Agents; Nociceptors; Pain; Receptors, Glutamate; Spinal Cord | 2006 |
Acute exposure to methylmercury at two developmental windows: focus on neurobehavioral and neurochemical effects in rat offspring.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain Chemistry; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Exploratory Behavior; Female; Glutamic Acid; Inhibition, Psychological; Male; Maze Learning; Methylmercury Compounds; Motor Activity; N-Methylaspartate; Neurons; Potassium Chloride; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Reflex, Startle; Rotarod Performance Test; Time Factors | 2006 |
Calpain product of WT-CRMP2 reduces the amount of surface NR2B NMDA receptor subunit.
Topics: Animals; Biotin; Blotting, Western; Calcium; Calpain; Cells, Cultured; Cerebral Cortex; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Excitatory Amino Acid Agonists; Glutamic Acid; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Membrane Proteins; Mice; N-Methylaspartate; Nerve Tissue Proteins; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2006 |
S-Nitrosoglutathione and glutathione act as NMDA receptor agonists in cultured hippocampal neurons.
Topics: Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Female; Glutamic Acid; Glutathione; Hippocampus; Magnesium; Morphine; N-Methylaspartate; Neurons; Nitric Oxide Donors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; S-Nitrosoglutathione; Signal Transduction; Synaptosomes | 2006 |
Enhanced activation of Ca2+/calmodulin-dependent protein kinase II upon downregulation of cyclin-dependent kinase 5-p35.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebral Cortex; Cyclin-Dependent Kinase 5; Down-Regulation; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Glutamic Acid; Immunoprecipitation; In Vitro Techniques; N-Methylaspartate; Neurons; Phosphorylation; Phosphotransferases; Protein Kinases; Purines; Rats; Roscovitine | 2006 |
Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum.
Topics: Animals; Cerebellum; Cerebrovascular Circulation; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Hydrazines; In Vitro Techniques; Male; Microcirculation; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Purkinje Cells; Quinoxalines; Rats; Rats, Wistar; Vasoconstriction; Vasodilation | 2006 |
Glutamate acts at NMDA receptors on fresh bovine and on cultured human retinal pigment epithelial cells to trigger release of ATP.
Topics: Adenosine Triphosphate; Animals; Calcium; Carrier Proteins; Cattle; Cell Line; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; N-Methylaspartate; Nerve Tissue Proteins; Pigment Epithelium of Eye; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Time Factors; Visual Pathways | 2006 |
Taurine potentiates presynaptic NMDA receptors in hippocampal Schaffer collateral axons.
Topics: Animals; Axons; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Organ Culture Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission; Taurine | 2006 |
A novel organotypic culture model of the postnatal mouse retina allows the study of glutamate-mediated excitotoxicity.
Topics: Animals; Apoptosis; Culture Media; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Models, Neurological; N-Methylaspartate; Nerve Degeneration; Organ Culture Techniques; Retina; Retinal Ganglion Cells | 2007 |
Interaction between glutamate and GABA systems in the integration of sympathetic outflow by the paraventricular nucleus of the hypothalamus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Blood Pressure; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Heart Rate; Male; N-Methylaspartate; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Sympathetic Nervous System | 2006 |
Unconventional neuroprotection against Ca2+ -dependent insults by metalloporphyrin catalytic antioxidants.
Topics: Animals; Antioxidants; Brain Ischemia; Calcium; Calcium Signaling; Catalysis; Cell Membrane; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Fluoresceins; Glutamic Acid; Metalloporphyrins; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Rats; Reactive Oxygen Species; Sodium-Calcium Exchanger; TRPM Cation Channels | 2006 |
Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic density.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Down-Regulation; Excitatory Amino Acid Agonists; Glutamic Acid; Microscopy, Electron, Transmission; N-Methylaspartate; Organ Culture Techniques; Presynaptic Terminals; Protein Subunits; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Synapses; Synaptic Membranes; Synaptic Transmission; Synaptosomes; Up-Regulation | 2006 |
Efficient generation of retinal progenitor cells from human embryonic stem cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Calcium; Carrier Proteins; Cell Differentiation; Cell Lineage; Cells, Cultured; Coculture Techniques; Embryo, Mammalian; Glutamic Acid; Humans; Mice; N-Methylaspartate; Retina; Stem Cells | 2006 |
Glutamate-induced protease-mediated loss of plasma membrane Ca2+ pump activity in rat hippocampal neurons.
Topics: Adenosine Triphosphatases; Amino Acid Chloromethyl Ketones; Animals; Calcium; Calcium-Transporting ATPases; Cation Transport Proteins; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Flow Cytometry; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Immunohistochemistry; Microscopy, Confocal; N-Methylaspartate; Neural Inhibition; Neurons; Peptide Hydrolases; Plasma Membrane Calcium-Transporting ATPases; Rats; Time Factors; Transfection | 2006 |
Brain-derived neurotrophic factor and neurotrophin receptors modulate glutamate-induced phase shifts of the suprachiasmatic nucleus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Clocks; Brain-Derived Neurotrophic Factor; Carbazoles; Circadian Rhythm; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; Indole Alkaloids; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Receptors, Glutamate; Receptors, Nerve Growth Factor; Suprachiasmatic Nucleus | 2006 |
Metallothionein, an endogenous antioxidant, protects against retinal neuron damage in mice.
Topics: Animals; Antioxidants; Buthionine Sulfoximine; Cell Culture Techniques; Cell Survival; Cholecalciferol; Glutamic Acid; Immunoenzyme Techniques; Injections; Male; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Oxidative Stress; Retinal Diseases; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation; Vitreous Body; Zinc Sulfate | 2006 |
Glutamine regulates expression of key transcription factor, signal transduction, metabolic gene, and protein expression in a clonal pancreatic beta-cell line.
Topics: Blotting, Western; Calcineurin; Clone Cells; Depression, Chemical; Electrophoretic Mobility Shift Assay; Gene Expression Profiling; Gene Expression Regulation; Glutamic Acid; Glutamine; Homeodomain Proteins; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; N-Methylaspartate; Oligonucleotide Array Sequence Analysis; Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Trans-Activators; Transcription Factors | 2006 |
The HSV-2 protein ICP10PK prevents neuronal apoptosis and loss of function in an in vivo model of neurodegeneration associated with glutamate excitotoxicity.
Topics: Animals; Apomorphine; Apoptosis; Behavior, Animal; Chlorocebus aethiops; Coloring Agents; Dopamine Agonists; Electron Transport Complex IV; Excitatory Amino Acids; Glutamic Acid; Immunohistochemistry; In Situ Nick-End Labeling; Indicators and Reagents; Injections; Male; Mice; Mitogen-Activated Protein Kinase Kinases; N-Methylaspartate; Neostriatum; Nerve Degeneration; Neurons; Neuroprotective Agents; Phenothiazines; Protein Serine-Threonine Kinases; Ribonucleotide Reductases; Vero Cells | 2007 |
Neuro-bioenergetic concepts in cancer prevention and treatment.
Topics: Acetylcholine; Antineoplastic Agents; Carcinogens; Fatty Acids; Glutamic Acid; Humans; Magnesium; Mutation; N-Methylaspartate; Neoplasms; Neurotransmitter Agents; Nitric Oxide; Purinergic P1 Receptor Antagonists; Sodium Channels; Somatomedins | 2007 |
Diltiazem protects human NT-2 neurons against excitotoxic damage in a model of simulated ischemia.
Topics: Animals; Animals, Newborn; Calcium; Cell Differentiation; Cell Hypoxia; Cell Survival; Cells, Cultured; Diltiazem; Drug Interactions; Glutamic Acid; Humans; Ischemia; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Teratocarcinoma; Time Factors | 2006 |
Acute unilateral ureteral distension inhibits glutamate-dependent spinal pelvic-urethra reflex potentiation via GABAergic neurotransmission in anesthetized rats.
Topics: Action Potentials; Afferent Pathways; Anesthesia; Animals; Bicuculline; Electromyography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hydrostatic Pressure; Long-Term Potentiation; N-Methylaspartate; Rats; Rats, Wistar; Reflex; Spinal Nerves; Synaptic Transmission; Ureter; Urethra | 2007 |
Neuroprotective mechanisms of taurine in vivo.
Topics: Ammonium Chloride; Amphetamines; Animals; Brain; Brain Chemistry; Central Nervous System Stimulants; Dopamine; Glutamic Acid; Glycine; Hydroxyl Radical; Male; Microdialysis; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sydnones; Taurine | 2006 |
Carnosine protects against NMDA-induced neurotoxicity in differentiated rat PC12 cells through carnosine-histidine-histamine pathway and H(1)/H(3) receptors.
Topics: Animals; Carnosine; Cell Differentiation; gamma-Aminobutyric Acid; Glutamic Acid; Histamine; Histidine; Methylhistidines; N-Methylaspartate; Neurons; PC12 Cells; Piperidines; Rats; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3 | 2007 |
Septohippocampal properties of N-methyl-D-aspartate-induced theta-band oscillation and synchrony.
Topics: Acetylcholine; Animals; Biological Clocks; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Hypothalamus, Posterior; Male; Motor Activity; N-Methylaspartate; Neural Pathways; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Septal Nuclei; Synaptic Transmission; Theta Rhythm | 2007 |
The direct and indirect effects of serofendic acid on neuroprotection.
Topics: Animals; Astrocytes; Cell Survival; Cells, Cultured; Cytokines; Diterpenes; Glutamic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Degeneration; Nerve Growth Factors; Neuroglia; Neurons; Neuroprotective Agents | 2006 |
Post-pubertal disruption of medial prefrontal cortical dopamine-glutamate interactions in a developmental animal model of schizophrenia.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Disease Models, Animal; Dopamine; Dopamine Agonists; Electrophysiology; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Prefrontal Cortex; Pregnancy; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Schizophrenia | 2007 |
Functional and structural characterization of D-aspartate oxidase from porcine kidney: non-Michaelis kinetics due to substrate activation.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; D-Aspartate Oxidase; Dicarboxylic Acids; Female; Glutamic Acid; Kidney; Kinetics; Molecular Sequence Data; N-Methylaspartate; Oxygen; Sequence Alignment; Sus scrofa | 2007 |
Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex.
Topics: Animals; Calcium; Cell Death; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Agonists; Glutamic Acid; Malonates; Motor Cortex; N-Methylaspartate; Neuroprotective Agents; Organ Culture Techniques; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Riluzole | 2007 |
Prenatal exposure to polybrominated diphenylether 99 enhances the function of the glutamate-nitric oxide-cGMP pathway in brain in vivo and in cultured neurons.
Topics: Age Factors; Animals; Animals, Newborn; Cells, Cultured; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Female; Gene Expression Regulation; Glutamic Acid; Halogenated Diphenyl Ethers; N-Methylaspartate; Neurons; Nitric Oxide; Penicillamine; Phenyl Ethers; Polybrominated Biphenyls; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Signal Transduction | 2007 |
Glutamate-induced activation of nitric oxide synthase is impaired in cerebral cortex in vivo in rats with chronic liver failure.
Topics: Ammonia; Animals; Blotting, Western; Cerebral Cortex; Chronic Disease; Cyclic GMP; Enzyme Activation; Fluorescent Antibody Technique, Indirect; Glutamic Acid; Immunohistochemistry; In Vitro Techniques; Liver Failure; Male; N-Methylaspartate; Nitrates; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 2007 |
Glutamate exocytosis from astrocytes controls synaptic strength.
Topics: Analysis of Variance; Animals; Astrocytes; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exocytosis; Glutamic Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; Microscopy, Immunoelectron; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Perforant Pathway; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2007 |
Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death.
Topics: ADP Ribose Transferases; Animals; Animals, Newborn; Botulinum Toxins; Brain; Calcium; cdc42 GTP-Binding Protein; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Functional Laterality; Glutamic Acid; Ischemia; Mice; Mitogen-Activated Protein Kinase 14; Models, Molecular; N-Methylaspartate; Neurons; rhoA GTP-Binding Protein; Transfection | 2007 |
The function of the glutamate-nitric oxide-cGMP pathway in brain in vivo and learning ability decrease in parallel in mature compared with young rats.
Topics: Aging; Animals; Brain; Cyclic GMP; Female; Glutamic Acid; Immunoblotting; Male; Maze Learning; Microdialysis; N-Methylaspartate; Nitric Oxide; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2007 |
Increased vulnerability of hippocampal neurons with age in culture: temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels.
Topics: Aging; Animals; Calcium; Calcium Channels, L-Type; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Embryo, Mammalian; Female; Gene Expression; Glutamic Acid; Hippocampus; L-Lactate Dehydrogenase; Membrane Potentials; N-Methylaspartate; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2007 |
Aloe-emodin metabolites protected N-methyl-d-aspartate-treated retinal ganglion cells by Cu-Zn superoxide dismutase.
Topics: Animals; Anthraquinones; Apoptosis; Chromatography, Liquid; Electrophoresis, Gel, Two-Dimensional; Emodin; Enzyme Inhibitors; Gene Expression Regulation; Glaucoma; Glucuronides; Glutamic Acid; N-Methylaspartate; Neuroprotective Agents; Polymerase Chain Reaction; Protein Processing, Post-Translational; Rats; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; RNA, Messenger; Spectrometry, Mass, Electrospray Ionization; Sulfates; Superoxide Dismutase; Transcription, Genetic | 2007 |
Nitrous oxide inhibits glutamatergic transmission in spinal dorsal horn neurons.
Topics: Animals; Excitatory Postsynaptic Potentials; Glutamic Acid; N-Methylaspartate; Neural Inhibition; Nitrous Oxide; Posterior Horn Cells; Rats; Rats, Wistar; Receptors, AMPA; Synaptic Transmission | 2008 |
Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Ketamine; Male; Muscarinic Agonists; N-Methylaspartate; Phenobarbital; Pilocarpine; Rats; Rats, Wistar; Receptors, GABA; Receptors, Neurotransmitter; Seizures; Status Epilepticus; Vigabatrin | 2007 |
The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Drug Interactions; Enzyme Inhibitors; ErbB Receptors; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Microscopy, Confocal; N-Methylaspartate; Neuregulin-1; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Quinazolines; Rats; Receptor, ErbB-4; RNA Interference; RNA, Small Interfering; Synapses; Synaptic Transmission; Transfection; Tyrphostins | 2007 |
Methamphetamine exposure antagonizes N-methyl-D-aspartate receptor-mediated neurotoxicity in organotypic hippocampal slice cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Binding, Competitive; Central Nervous System Stimulants; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Antagonism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Male; Methamphetamine; N-Methylaspartate; Neurons; Neurotoxins; Organ Culture Techniques; Pyramidal Cells; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2007 |
Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons.
Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Cerebellum; Energy Metabolism; Glutamic Acid; Mitochondria; Mitochondrial Proteins; N-Methylaspartate; Neurons; Oxidative Stress; Proteome; Proteomics; Rats; Tacrine | 2007 |
Raloxifene acutely reduces glutamate-induced intracellular calcium increase in cultured rat cortical neurons via inhibition of high-voltage-activated calcium current.
Topics: Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cell Membrane; Cells, Cultured; Cerebral Cortex; Diagnostic Imaging; Electrophysiology; Endoplasmic Reticulum; Estradiol; Estrogen Antagonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fulvestrant; Glutamic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Thapsigargin | 2007 |
Damipipecolin and damituricin, novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella damicornis.
Topics: Alkaloids; Animals; Axinella; Bromine; Calcium; Cell Survival; Cells, Cultured; Glutamic Acid; Humans; Mediterranean Region; Molecular Structure; N-Methylaspartate; Neurons; Pyrroles; Rats; Suberites | 2007 |
Activation of extrasynaptic NMDA receptors induces a PKC-dependent switch in AMPA receptor subtypes in mouse cerebellar stellate cells.
Topics: Animals; Benzodiazepines; Calcium; Carrier Proteins; Cell Cycle Proteins; Cerebellum; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuronal Plasticity; Nuclear Proteins; Organophosphonates; Peptide Fragments; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Time Factors | 2007 |
Effects of anti-glutamic acid decarboxylase antibodies associated with neurological diseases.
Topics: Animals; Autoantibodies; Cerebellum; Chromatography, Affinity; Drug Administration Routes; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Agonists; Glutamate Decarboxylase; Glutamic Acid; Humans; Immunoglobulin G; Male; Microdialysis; Muscle, Skeletal; N-Methylaspartate; Nervous System Diseases; Nitric Oxide; Rats; Sciatic Nerve; Spinal Cord | 2007 |
The role of defensins in the excitability of the peripheral vestibular system in the frog: evidence for the presence of communication between the immune and nervous systems.
Topics: Acetylcholine; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha-Defensins; Animals; Atropine; Cholinergic Antagonists; Cycloleucine; Defensins; Dose-Response Relationship, Drug; Glutamic Acid; Humans; Immune System; In Vitro Techniques; Inflammation; Kainic Acid; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neuroimmunomodulation; Neurons, Afferent; Rabbits; Rana temporaria; Receptors, Cholinergic; Receptors, Glutamate; Receptors, Opioid; Semicircular Canals; Synaptic Transmission; Vestibule, Labyrinth | 2007 |
Effect of the L- or D-aspartate on ecto-5'nucleotidase activity and on cellular viability in cultured neurons: participation of the adenosine A(2A) receptors.
Topics: 5'-Nucleotidase; Adenosine Monophosphate; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebellum; D-Aspartic Acid; Glutamic Acid; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Receptor, Adenosine A2A | 2007 |
Dopamine receptor activation reveals a novel, kynurenate-sensitive component of striatal N-methyl-D-aspartate neurotoxicity.
Topics: Animals; Astrocytes; Cell Death; Corpus Striatum; Dopamine; Dopamine Agonists; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Humans; Kynurenic Acid; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate | 2007 |
Decursinol and decursin protect primary cultured rat cortical cells from glutamate-induced neurotoxicity.
Topics: Angelica; Animals; Antioxidants; Benzopyrans; Butyrates; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Glutathione; Glutathione Peroxidase; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2007 |
Intrathecal substance P (1-7) prevents morphine-evoked spontaneous pain behavior via spinal NMDA-NO cascade.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Glutamic Acid; Male; Morphine; N-Methylaspartate; Nitrates; Nitric Oxide; Nitrites; Pain; Peptide Fragments; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Time Factors | 2007 |
Modulation of extracellular proton fluxes from retinal horizontal cells of the catfish by depolarization and glutamate.
Topics: Animals; Calcium; Catfishes; Excitatory Amino Acid Agonists; Glutamic Acid; Hydrogen-Ion Concentration; Kainic Acid; Membrane Potentials; Microelectrodes; N-Methylaspartate; Patch-Clamp Techniques; Potassium; Protons; Retinal Horizontal Cells; Sodium-Hydrogen Exchangers | 2007 |
Modulation of interleukin-6 and matrix metalloproteinase 2 expression in human fibroblast-like synoviocytes by functional ionotropic glutamate receptors.
Topics: Adult; Animals; Calcium; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Fibroblasts; Gene Expression; GluK2 Kainate Receptor; Glutamic Acid; Hindlimb; Humans; Interleukin-6; Kainic Acid; Male; Matrix Metalloproteinase 2; Menisci, Tibial; Middle Aged; N-Methylaspartate; Rats; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; RNA, Messenger; Synovial Membrane; Tissue Inhibitor of Metalloproteinases | 2007 |
N-methyl-D-aspartate autoreceptors respond to low and high agonist concentrations by facilitating, respectively, exocytosis and carrier-mediated release of glutamate in rat hippocampus.
Topics: Animals; Aspartic Acid; Autoreceptors; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exocytosis; Glutamic Acid; Glycine; Hippocampus; HIV Envelope Protein gp120; Male; N-Methylaspartate; Presynaptic Terminals; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Synaptosomes; Vesicular Glutamate Transport Proteins | 2007 |
Glycine stimulates the release of labeled acetylcholine but not dopamine nor glutamate from superfused rat striatal tissue.
Topics: Acetylcholine; Analysis of Variance; Animals; Antipsychotic Agents; Calcium; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Glycine Agents; Haloperidol; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Wistar; Sodium Channel Blockers; Tetrodotoxin; Time Factors; Tritium | 2007 |
NMDA-mediated release of glutamate and GABA in the subthalamic nucleus is mediated by dopamine: an in vivo microdialysis study in rats.
Topics: Animals; Dopamine; Dopamine Antagonists; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; N-Methylaspartate; Neurons; Neurotoxins; Oxidopamine; Rats; Rats, Wistar; Receptors, Dopamine; Subthalamic Nucleus; Synaptic Transmission | 2007 |
Effect of exogenous glutamate and N-Methyl-D-aspartic acid on spontaneous activity of isolated human ureter.
Topics: Adult; Aged; Cycloleucine; Female; Glutamic Acid; Humans; In Vitro Techniques; Kainic Acid; Male; Middle Aged; Muscle, Smooth; N-Methylaspartate; Ureter | 2007 |
D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Enzyme Activation; Enzyme Induction; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Humans; Mice; Mice, Transgenic; Middle Aged; Motor Neurons; Mutation; N-Methylaspartate; Neuroglia; p38 Mitogen-Activated Protein Kinases; Racemases and Epimerases; Serine; Spinal Cord; Superoxide Dismutase; Up-Regulation | 2007 |
Extracellular glutamate concentration in hippocampal slice.
Topics: Action Potentials; Animals; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; Hippocampus; In Vitro Techniques; N-Methylaspartate; Patch-Clamp Techniques; Pyramidal Cells; Rats; Receptors, N-Methyl-D-Aspartate | 2007 |
A synthetic kainoid, (2S,3R,4R)-3-carboxymethyl-4-(phenylthio)pyrrolidine-2-carboxylic acid (PSPA-1) serves as a novel anti-allodynic agent for neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Hyperalgesia; Immunohistochemistry; Inflammation; Kainic Acid; Mice; Mononeuropathies; N-Methylaspartate; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Pain; Spinal Cord; Time Factors | 2007 |
Diphenyl diselenide attenuates acute thermal hyperalgesia and persistent inflammatory and neuropathic pain behavior in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Benzene Derivatives; Bradykinin; Dinoprostone; Freund's Adjuvant; Glutamic Acid; Hyperalgesia; Inflammation Mediators; Male; Mice; N-Methylaspartate; Neuralgia; Neurogenic Inflammation; Nociceptors; Organoselenium Compounds; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Sciatic Neuropathy | 2007 |
Dopamine D(1) and D(3) receptors oppositely regulate NMDA- and cocaine-induced MAPK signaling via NMDA receptor phosphorylation.
Topics: Animals; Blotting, Western; Brain Chemistry; Caudate Nucleus; Cocaine; Data Interpretation, Statistical; Dizocilpine Maleate; Dopamine Uptake Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; N-Methylaspartate; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Putamen; Receptors, Dopamine D1; Receptors, Dopamine D3; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2007 |
Interferon-beta is neuroprotective against the toxicity induced by activated microglia.
Topics: Animals; Cells, Cultured; Coculture Techniques; Cytokines; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Interferon Type I; Interleukin-1beta; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microglia; Molsidomine; N-Methylaspartate; Neurons; Neuroprotective Agents; Nitric Oxide; Peroxynitrous Acid; Pregnancy; Recombinant Proteins; Superoxides; Tumor Necrosis Factor-alpha | 2007 |
Activation of mu-opioid receptor selectively potentiates NMDA-induced outward currents in rat locus coeruleus neurons.
Topics: Action Potentials; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Locus Coeruleus; N-Methylaspartate; Narcotic Antagonists; Neural Inhibition; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Synaptic Transmission | 2008 |
The effects of glutamate receptor antagonists on cerebellar granule cell survival and development.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; In Situ Nick-End Labeling; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Tetrazolium Salts; Thiazoles; Time Factors | 2008 |
Glutamate-mediated spinal reflex potentiation involves ERK 1/2 phosphorylation in anesthetized rats.
Topics: Analysis of Variance; Anesthesia; Animals; Drug Interactions; Electric Stimulation; Electromyography; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Mitogen-Activated Protein Kinase 3; N-Methylaspartate; Peripheral Nerves; Phosphorylation; Rats; Rats, Wistar; Reflex; Spinal Cord; Urethra | 2008 |
Identification of a molecular target for glutamate regulation of astrocyte water permeability.
Topics: Animals; Animals, Newborn; Aquaporin 4; Astrocytes; Benzylamines; Calcium; Cell Line, Transformed; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Methoxyhydroxyphenylglycol; N-Methylaspartate; Permeability; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Serine; Sulfonamides; Transfection; Water | 2008 |
Glutamate-stimulated release of norepinephrine in hippocampal slices of animal models of attention-deficit/hyperactivity disorder (spontaneously hypertensive rat) and depression/anxiety-like behaviours (Wistar-Kyoto rat).
Topics: Animals; Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; Depressive Disorder; Disease Models, Animal; Endocytosis; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Male; N-Methylaspartate; Norepinephrine; Organ Culture Techniques; Presynaptic Terminals; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Species Specificity; Synaptic Transmission | 2008 |
Neuroprotective effects of nicotinamide and 1-methylnicotinamide in acute excitotoxicity in vitro.
Topics: Animals; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Glutamic Acid; In Vitro Techniques; Membrane Potential, Mitochondrial; N-Methylaspartate; Neurons; Neuroprotective Agents; Niacinamide; Oxidative Stress; Rats | 2008 |
Nitric oxide in glutamate-induced compound action potential threshold shifts.
Topics: Action Potentials; Animals; Cochlear Microphonic Potentials; Dose-Response Relationship, Drug; Gerbillinae; Glutamic Acid; Indazoles; Models, Biological; N-Methylaspartate; Neurotransmitter Agents; Nitric Oxide; Perfusion; Receptors, Glutamate; Time Factors | 2008 |
A possible mechanism for the beneficial effect of ethanol in essential tremor.
Topics: Animals; Brain; Central Nervous System Depressants; Central Nervous System Stimulants; Essential Tremor; Ethanol; Glutamic Acid; Glycerol; Harmaline; Lactic Acid; Male; Microdialysis; N-Methylaspartate; Pyruvic Acid; Rats; Rats, Wistar | 2008 |
Neuroadaptive changes in the mesocortical glutamatergic system during chronic nicotine self-administration and after extinction in rats.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electrochemistry; Excitatory Amino Acid Agents; Extinction, Psychological; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; N-Methylaspartate; Nicotine; Nicotinic Agonists; Potassium Chloride; Prefrontal Cortex; Rats; Rats, Inbred Lew; Self Administration; Ventral Tegmental Area | 2008 |
STAT3 activation protects retinal ganglion cell layer neurons in response to stress.
Topics: Adenoviridae; Animals; Cell Survival; Cells, Cultured; Cytoprotection; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Rats; Rats, Long-Evans; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; STAT3 Transcription Factor; Stress, Physiological | 2008 |
NMDA and GABA B receptors are involved in controlling nematocyst discharge in hydra.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Dose-Response Relationship, Drug; Epinephrine; Glutamic Acid; Glycine; Hydra; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Receptors, GABA-B; Serotonin | 2008 |
Regulation of the maturation of osteoblasts and osteoclastogenesis by glutamate.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Differentiation; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Male; N-Methylaspartate; Osteoblasts; Osteocalcin; Osteoclasts; Osteogenesis; Phosphorylation; RANK Ligand; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tibia; Time Factors | 2008 |
Non-N-methyl-D-aspartate glutamate receptors in the paraventricular nucleus of hypothalamus mediate the pressor response evoked by noradrenaline microinjected into the lateral septal area in rats.
Topics: Animals; Cardiovascular Physiological Phenomena; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Intraventricular; Limbic System; Male; Microinjections; N-Methylaspartate; Norepinephrine; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Receptors, Glutamate; Vasopressins | 2008 |
GABAA and strychnine-sensitive glycine receptors modulate N-methyl-D-aspartate-evoked acetylcholine release from rat spinal motoneurons: a possible role in neuroprotection.
Topics: Acetylcholine; Animals; Cells, Cultured; Glutamic Acid; Motor Neurons; N-Methylaspartate; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Spinal Nerves | 2008 |
Preconditioning with NMDA protects against toxicity of 3-nitropropionic acid or glutamate in cultured cerebellar granule neurons.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Survival; Cells, Cultured; Cerebellum; Convulsants; Dose-Response Relationship, Drug; Glutamic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Nitro Compounds; Propionates; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
(+)-(S)-trujillon, (+)-(S)-4-(2,2-diphenyl-1,3,2-oxazabolidin-5-oxo)propionic acid, a novel glutamatergic analog, modifies the activity of globus pallidus neurons by selective NMDA receptor activation.
Topics: Animals; Basal Ganglia; Boron Compounds; Dose-Response Relationship, Drug; Globus Pallidus; Glutamic Acid; Male; Motor Activity; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Receptors, Ionotropic Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 2011 |
Interaction between glutamatergic-NMDA and cholinergic-muscarinic systems in classical fear conditioning.
Topics: Animals; Behavior, Animal; Conditioning, Classical; Dicyclomine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fear; Glutamic Acid; Hippocampus; Male; Muscarinic Antagonists; N-Methylaspartate; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptors, N-Methyl-D-Aspartate | 2008 |
GMP prevents excitotoxicity mediated by NMDA receptor activation but not by reversal activity of glutamate transporters in rat hippocampal slices.
Topics: Animals; Aspartic Acid; Brain Diseases, Metabolic; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanosine Monophosphate; Hippocampus; Male; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Vesicular Glutamate Transport Proteins | 2008 |
[Apoptosis and its receptor selective pathways during neurotoxic action of glutamate].
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Necrosis; Neurons; Rats; Rats, Wistar; Receptors, Glutamate; Tumor Suppressor Protein p53 | 2008 |
Cerebromicrovascular endothelial cells are resistant to L-glutamate.
Topics: Animals; Animals, Newborn; Arterioles; Astrocytes; Bradykinin; Brain; Calcium Signaling; Cell Hypoxia; Cell Survival; Cells, Cultured; Coculture Techniques; Drug Resistance; Endothelial Cells; Glutamic Acid; Hypercapnia; Male; Membrane Proteins; N-Methylaspartate; Occludin; Pericytes; Phosphoproteins; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sus scrofa; Zonula Occludens-1 Protein | 2008 |
An attractor hypothesis of obsessive-compulsive disorder.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Models, Neurological; N-Methylaspartate; Nerve Net; Neurons; Obsessive-Compulsive Disorder; Receptors, AMPA; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2008 |
Glutamatergic stimulation of luteinising hormone secretion in relatively refractory male songbirds.
Topics: Animals; Excitatory Amino Acid Agonists; Glutamic Acid; Gonadotropin-Releasing Hormone; Light; Luteinizing Hormone; Male; N-Methylaspartate; Neurons; Photoperiod; Preoptic Area; Seasons; Sexual Behavior, Animal; Songbirds; Testis; Time Factors | 2008 |
Interplay between glutamate and serotonin within the dorsal periaqueductal gray modulates anxiety-related behavior of rats exposed to the elevated plus-maze.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Maze Learning; N-Methylaspartate; Periaqueductal Gray; Piperazines; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2008 |
Serotoninergic modulation of sensory transmission to brainstem reticulospinal cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Stem; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Lampreys; N-Methylaspartate; Neural Pathways; Receptors, Glutamate; Reticular Formation; Serotonin; Spinal Cord; Synaptic Transmission; Trigeminal Nerve | 2008 |
A plateau potential mediated by the activation of extrasynaptic NMDA receptors in rat hippocampal CA1 pyramidal neurons.
Topics: Action Potentials; Animals; Calcium; Calcium Channel Blockers; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Male; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Synaptic Transmission | 2008 |
Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Microscopy, Electron, Scanning; N-Methylaspartate; Potassium Chloride; Pregnenolone; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tritium; Valine | 2008 |
Increased tyrosine phosphorylation of PSD-95 by Src family kinases after brain ischaemia.
Topics: Animals; Binding Sites; Brain Ischemia; Cells, Cultured; Chlorocebus aethiops; COS Cells; Disks Large Homolog 4 Protein; Glutamic Acid; Hippocampus; Immunoblotting; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mutation; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; src-Family Kinases; Tyrosine | 2009 |
Blockade of NMDA receptors in the prefrontal cortex increases dopamine and acetylcholine release in the nucleus accumbens and motor activity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cholinergic Antagonists; Dopamine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Flupenthixol; Glutamic Acid; Homovanillic Acid; Injections, Intraventricular; Male; Mecamylamine; Microinjections; Motor Activity; Muscarinic Antagonists; N-Methylaspartate; Nicotinic Antagonists; Nucleus Accumbens; Piperazines; Prefrontal Cortex; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Scopolamine | 2008 |
Fast inhibition of glutamate-activated currents by caffeine.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Central Nervous System Stimulants; Glutamic Acid; Mice; Models, Biological; N-Methylaspartate; Neurons; Neurotransmitter Agents; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2008 |
Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function.
Topics: Age Factors; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Calcium; Cells, Cultured; Cerebral Cortex; Drug Interactions; Fibrinolysin; Glutamic Acid; Glycine; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Oocytes; Patch-Clamp Techniques; Protease Nexins; rap GTP-Binding Proteins; Rats; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Thrombin; Tissue Plasminogen Activator; Xenopus laevis | 2008 |
Differential inhibition of globus pallidus neurons by electrical or chemical stimulation of the striatum.
Topics: Action Potentials; Animals; Biophysics; Corpus Striatum; Electric Stimulation; Excitatory Amino Acid Agents; Globus Pallidus; Glutamic Acid; Male; N-Methylaspartate; Neural Inhibition; Neural Pathways; Neurons; Quinoxalines; Rats; Rats, Wistar; Stimulation, Chemical | 2008 |
Exposure to cyclic intermittent hypoxia increases expression of functional NMDA receptors in the rat carotid body.
Topics: Adaptation, Physiological; Animals; Blotting, Western; Carotid Body; Carotid Sinus; Disease Models, Animal; Disks Large Homolog 4 Protein; Endothelin-1; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine 3-Monooxygenase; Up-Regulation | 2009 |
Excitatory neurosteroids attenuate apoptotic and excitotoxic cell death in primary cortical neurons.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Death; Cerebral Cortex; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Enzyme Inhibitors; Excitatory Amino Acids; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Neurotransmitter Agents; Phosphoinositide-3 Kinase Inhibitors; Pregnanolone; Pregnenolone; Reactive Oxygen Species; Staurosporine; Steroids | 2008 |
Bidirectional regulation of kainate receptor surface expression in hippocampal neurons.
Topics: Animals; Cell Membrane; Gene Expression Regulation; GluK2 Kainate Receptor; Glutamic Acid; Hippocampus; Hydrogen-Ion Concentration; Kainic Acid; Microscopy, Confocal; Models, Biological; N-Methylaspartate; Neurons; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Sindbis Virus | 2008 |
N-Methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors involved in the induction of sedative effects under an acute stress in neonatal chicks.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chickens; Excitatory Amino Acid Agonists; Glutamic Acid; Immobility Response, Tonic; Kainic Acid; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Stress, Psychological | 2009 |
Glutamatergic stimulation triggers rapid Krüpple-like factor 4 expression in neurons and the overexpression of KLF4 sensitizes neurons to NMDA-induced caspase-3 activity.
Topics: Animals; Blotting, Western; Caspase 3; Cells, Cultured; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Glutamic Acid; Hippocampus; Immunohistochemistry; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Mice; N-Methylaspartate; Neurons; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation | 2009 |
Glutamate receptors modulate sodium-dependent and calcium-independent vitamin C bidirectional transport in cultured avian retinal cells.
Topics: Animals; Animals, Newborn; Ascorbic Acid; Aspartic Acid; Biological Transport; Calcium; Chelating Agents; Chick Embryo; Cytoskeletal Proteins; Egtazic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Neurons; Organic Anion Transporters, Sodium-Dependent; Rats; Receptors, Glutamate; Retina; Sodium; Sodium-Coupled Vitamin C Transporters; Symporters; Tissue Culture Techniques; Tritium | 2009 |
Reprogramming chick RPE progeny cells to differentiate towards retinal neurons by ash1.
Topics: Animals; Avian Proteins; Basic Helix-Loop-Helix Transcription Factors; Biomarkers; Cell Differentiation; Cells, Cultured; Cellular Reprogramming; Chick Embryo; Gene Expression Regulation, Developmental; Glutamic Acid; Glycine; Immunohistochemistry; N-Methylaspartate; Neuroglia; Retinal Neurons; Retinal Pigment Epithelium; Retroviridae; Stem Cells; Vimentin; Virus Replication | 2008 |
Astrocyte-derived MCP-1 mediates neuroprotective effects of noradrenaline.
Topics: Adenosine Triphosphate; Adrenergic beta-Antagonists; Animals; Animals, Newborn; Astrocytes; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Chemokine CCL2; Coculture Techniques; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Glucose; Glutamic Acid; Hypoxia; L-Lactate Dehydrogenase; Microglia; N-Methylaspartate; Neurons; Neuroprotective Agents; Norepinephrine; Propanolamines; Propranolol; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transfection | 2009 |
Glutamatergic modulation of cerebellar interneuron activity is mediated by an enhancement of GABA release and requires protein kinase A/RIM1alpha signaling.
Topics: Action Potentials; Animals; Animals, Newborn; Cerebellum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; GTP-Binding Proteins; In Vitro Techniques; Interneurons; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Patch-Clamp Techniques; Pyridazines; Signal Transduction; Synaptic Potentials | 2009 |
Elevated glutamate and NMDA disrupt production of the second messenger cyclic GMP in the early postnatal mouse cortex.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Cyclic GMP; Glutamic Acid; Immunohistochemistry; Mice; N-Methylaspartate; Organ Culture Techniques | 2009 |
Glutamate, microdialysis, and cerebral ischemia: lost in translation?
Topics: Amino Acids; Animals; Brain Ischemia; gamma-Aminobutyric Acid; Glutamic Acid; Microdialysis; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate | 2009 |
GABA(A)- and AMPA-like receptors modulate the activity of an identified neuron within the central pattern generator of the pond snail Lymnaea stagnalis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Clocks; Brain; Excitatory Amino Acid Agonists; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Lymnaea; Membrane Potentials; N-Methylaspartate; Neural Inhibition; Neurons; Picrotoxin; Receptors, AMPA; Receptors, GABA-A; Respiration | 2009 |
Glutamate signaling in chondrocytes and the potential involvement of NMDA receptors in cell proliferation and inflammatory gene expression.
Topics: Animals; Cartilage, Articular; Cell Proliferation; Cells, Cultured; Chondrocytes; Gene Expression; Glutamic Acid; Humans; Immunohistochemistry; N-Methylaspartate; Osteoarthritis; Rats | 2009 |
Apoptosis and the receptor specificity of its mechanisms during the neurotoxic action of glutamate.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Necrosis; Neurons; Rats; Rats, Wistar; Receptors, Glutamate; Tumor Suppressor Protein p53 | 2009 |
Protein SUMOylation modulates calcium influx and glutamate release from presynaptic terminals.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Central Nervous System Stimulants; Endopeptidases; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Potassium Chloride; Presynaptic Terminals; Rats; Rats, Wistar; Recombinant Proteins; Small Ubiquitin-Related Modifier Proteins; SUMO-1 Protein; Synaptic Transmission; Synaptosomes | 2009 |
Glutamatergic transmission in hydra: NMDA/D-serine affects the electrical activity of the body and tentacles of Hydra vulgaris (Cnidaria, Hydrozoa).
Topics: Analysis of Variance; Animals; Electrophysiology; Extremities; Glutamic Acid; Hydra; Motor Activity; N-Methylaspartate; Serine; Synaptic Transmission | 2009 |
Synaptic and extrasynaptic factors governing glutamatergic retinal waves.
Topics: Amino Acid Transport Systems, Acidic; Animals; Animals, Newborn; Aspartic Acid; Calcium; Dihydro-beta-Erythroidine; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; N-Methylaspartate; Neural Inhibition; Nicotinic Antagonists; Patch-Clamp Techniques; Pyridazines; Quinoxalines; Retinal Ganglion Cells; Synapses; Synaptic Transmission; Time Factors; Valine; Vesicular Glutamate Transport Protein 1 | 2009 |
Neurophysiological and neurochemical animal models of schizophrenia: focus on glutamate.
Topics: Acoustic Stimulation; Amphetamine; Animals; Brain; Disease Models, Animal; Dopamine; Electroencephalography; Evoked Potentials, Auditory; Glutamic Acid; Haplorhini; Humans; Microdialysis; N-Methylaspartate; Rats; Schizophrenia; Schizophrenic Psychology; Synaptic Transmission | 2009 |
The prostanoid EP(2) receptor agonist ONO-AE1-259-01 protects against glutamate-induced neurotoxicity in rat retina.
Topics: Animals; Cell Count; Dinoprostone; Glutamic Acid; Injections; Male; N-Methylaspartate; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Retina; Retinal Degeneration; Retinal Ganglion Cells | 2009 |
Silent synapses onto interneurons in the rat CA1 stratum radiatum.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Electric Stimulation; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Hippocampus; In Vitro Techniques; Interneurons; Male; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Synapses | 2009 |
Polysaccharides from wolfberry antagonizes glutamate excitotoxicity in rat cortical neurons.
Topics: Animals; Antioxidants; Cell Death; Cerebral Cortex; Glutamic Acid; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Lycium; Memantine; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Phosphorylation; Polysaccharides; Rats | 2009 |
Moderate hypobaric hypoxia modifies Ca2+-mediated glutamatergic signal transduction in rat cerebral cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cerebral Cortex; Excitatory Amino Acid Agonists; Glutamic Acid; Hypoxia; Male; N-Methylaspartate; Rats; Rats, Wistar; Signal Transduction | 2009 |
Polychlorinated biphenyls PCB 153 and PCB 126 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms.
Topics: Animals; Animals, Newborn; Calcium; Cell Survival; Cells, Cultured; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Excitatory Amino Acid Agents; Glutamic Acid; N-Methylaspartate; Neurons; Neurotoxins; Nitric Oxide; Polychlorinated Biphenyls; Rats; Rats, Wistar; Signal Transduction; Time Factors | 2009 |
GIF-0173 protects against cerebral infarction through DP1 receptor activation.
Topics: Animals; Brain Infarction; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Cerebrovascular Circulation; Dantrolene; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Hydantoins; Infarction, Middle Cerebral Artery; Intracellular Fluid; Lactones; Laser-Doppler Flowmetry; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; Platelet Aggregation Inhibitors; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Immunologic; Receptors, Prostaglandin; Sesquiterpenes; Severity of Illness Index; Tetrazolium Salts | 2009 |
Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine.
Topics: Animals; Biophysical Phenomena; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; Fructose; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Neuroprotective Agents; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Raclopride; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Synaptic Transmission; Topiramate | 2009 |
Glutamate responsiveness of medial vestibular nucleus neurons in aged rats.
Topics: Action Potentials; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Glutamic Acid; In Vitro Techniques; Male; Microelectrodes; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Vestibular Nuclei | 2010 |
Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.
Topics: Animals; Calcium Signaling; Chick Embryo; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Malonates; Mitochondria; Motor Neuron Disease; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Organ Culture Techniques; Propionates; Riluzole; Spinal Cord | 2009 |
Preconditioning with 4-aminopyridine protects cerebellar granule neurons against excitotoxicity.
Topics: 4-Aminopyridine; Animals; Bicuculline; Cell Death; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; GABA Antagonists; Glutamic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Propionates; Rats; Rats, Sprague-Dawley; Time Factors | 2009 |
Glutamate receptor properties of human mesencephalic neural progenitor cells: NMDA enhances dopaminergic neurogenesis in vitro.
Topics: Calcium; Cells, Cultured; Dopamine; Embryonic Stem Cells; Fetus; Glutamic Acid; Humans; Membrane Potentials; Mesencephalon; N-Methylaspartate; Neurogenesis; Neurons; Patch-Clamp Techniques; Receptors, Glutamate | 2009 |
Oxidative stress upregulates the NMDA receptor on cerebrovascular endothelium.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Blotting, Western; Cells, Cultured; Cerebrovascular Circulation; Endothelium, Vascular; Glutamic Acid; Immunoenzyme Techniques; Mice; N-Methylaspartate; Oxidative Stress; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2009 |
How can an inert gas counterbalance a NMDA-induced glutamate release?
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Asparagine; Aspartic Acid; Catheters, Indwelling; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Excitatory Amino Acid Agonists; Glutamic Acid; Glutamine; Homovanillic Acid; Inert Gas Narcosis; Male; Microdialysis; N-Methylaspartate; Nitrogen; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Statistics, Nonparametric | 2009 |
Dual effect of glutamate on GABAergic interneuron survival during cerebral cortex development in mice neonates.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Calcium; Caspase 3; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Glutamate Decarboxylase; Glutamic Acid; Green Fluorescent Proteins; In Vitro Techniques; Interneurons; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Mice; Mice, Transgenic; N-Methylaspartate; Necrosis; RNA, Small Interfering | 2010 |
Alterations in calcium signaling and a decrease in Bcl-2 expression: possible correlation with apoptosis in aged striatum.
Topics: Aging; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Calcium; Corpus Striatum; Fluorescent Antibody Technique; Glutamic Acid; In Situ Nick-End Labeling; In Vitro Techniques; Mitochondria; N-Methylaspartate; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Time Factors | 2010 |
Encoding and decoding bursts by NMDA spikes in basal dendrites of layer 5 pyramidal neurons.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Cerebral Cortex; Computer Simulation; Dendrites; Electric Stimulation; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Neuronal Plasticity; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Synapses; Time Factors | 2009 |
Early exposure of cultured hippocampal neurons to excitatory amino acids protects from later excitotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Survival; Cells, Cultured; Excitatory Amino Acids; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Rats | 2010 |
Cholinergic modulation of non-N-methyl-D-aspartic acid glutamatergic transmission in the chick ventral lateral geniculate nucleus.
Topics: Acetylcholine; Analysis of Variance; Animals; Chick Embryo; Electric Stimulation; Excitatory Postsynaptic Potentials; Geniculate Bodies; Glutamic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Presynaptic Terminals; Receptors, Muscarinic; Receptors, Nicotinic; Synaptic Transmission; Visual Pathways | 2010 |
Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knockout mice by reducing glutamate excitotoxicity.
Topics: Amino Acid Transport System X-AG; Animals; Apoptosis; Astrocytes; Carnosine; Glutamic Acid; Histidine Decarboxylase; Infarction, Middle Cerebral Artery; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; N-Methylaspartate; Neuroprotective Agents; PC12 Cells; Rats; Reactive Oxygen Species; Rotenone | 2010 |
Neuregulin beta1 enhances peak glutamate-induced intracellular calcium levels through endoplasmic reticulum calcium release in cultured hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Chemistry; Calcium; Calcium Signaling; Cells, Cultured; Endoplasmic Reticulum; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Hippocampus; Inositol 1,4,5-Trisphosphate Receptors; N-Methylaspartate; Neuregulin-1; Neurons; Potassium Chloride; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Ryanodine; Ryanodine Receptor Calcium Release Channel; Second Messenger Systems | 2009 |
Acute p38-mediated inhibition of NMDA-induced outward currents in hippocampal CA1 neurons by interleukin-1beta.
Topics: Animals; CA1 Region, Hippocampal; Cells, Cultured; Dose-Response Relationship, Drug; Encephalitis; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Interleukin-1beta; Membrane Potentials; Mice; Mice, Inbred C57BL; Microglia; N-Methylaspartate; Neural Inhibition; Neurons; p38 Mitogen-Activated Protein Kinases; Receptors, Interleukin-1; Receptors, N-Methyl-D-Aspartate; Synaptic Potentials; Synaptic Transmission | 2010 |
Dopamine modulation of excitatory currents in the striatum is dictated by the expression of D1 or D2 receptors and modified by endocannabinoids.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cannabinoid Receptor Modulators; Cells, Cultured; Corpus Striatum; Dopamine; Endocannabinoids; Excitatory Postsynaptic Potentials; Glutamic Acid; Green Fluorescent Proteins; In Vitro Techniques; Membrane Potentials; Mice; Mice, Transgenic; N-Methylaspartate; Neurons; Receptor, Cannabinoid, CB1; Receptors, Dopamine D1; Receptors, Dopamine D2; Signal Transduction; Synapses | 2010 |
Activation of presynaptic alpha7 nicotinic receptors evokes an excitatory response in hippocampal CA3 neurones in anaesthetized rats: an in vivo iontophoretic study.
Topics: 2-Amino-5-phosphonovalerate; Aconitine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; D-Aspartic Acid; Glutamic Acid; Hippocampus; Male; N-Methylaspartate; Neurons; Nicotine; Nicotinic Antagonists; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Presynaptic; Spiro Compounds | 2010 |
The effects of polyamine agonists and antagonists on N-methyl-D-aspartate-induced depolarizations of amphibian motoneurons in situ.
Topics: Animals; Central Nervous System Agents; Glutamic Acid; In Vitro Techniques; Magnesium; Membrane Potentials; Microelectrodes; Motor Neurons; N-Methylaspartate; Polyamines; Rana pipiens; Receptor, Serotonin, 5-HT2B; Receptors, G-Protein-Coupled; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Serotonin; Spinal Cord | 2010 |
In vivo modulation of nitric oxide concentration dynamics upon glutamatergic neuronal activation in the hippocampus.
Topics: Animals; CA1 Region, Hippocampal; Dentate Gyrus; Dizocilpine Maleate; Electrochemical Techniques; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microelectrodes; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2011 |
Developmental exposure to polychlorinated biphenyls 52, 138 or 180 affects differentially learning or motor coordination in adult rats. Mechanisms involved.
Topics: Animals; Cerebellum; Cyclic GMP; Discrimination, Psychological; Environmental Pollutants; Extracellular Space; Female; gamma-Aminobutyric Acid; Glutamic Acid; Learning; Male; Maternal Exposure; Maze Learning; N-Methylaspartate; Polychlorinated Biphenyls; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Performance; Rats; Receptors, N-Methyl-D-Aspartate; Sex Factors | 2010 |
Growth hormone rescues hippocampal synaptic function after sleep deprivation.
Topics: Animals; D-Aspartic Acid; Glutamic Acid; Growth Hormone; Hippocampus; Long-Term Potentiation; Male; Memory; N-Methylaspartate; Neurons; Protein Subunits; Rats; Rats, Sprague-Dawley; Signal Transduction; Sleep Deprivation | 2010 |
Induced tolerance to glutamate neurotoxicity through down-regulation of NR2 subunits of N-methyl-D-aspartate receptors in cultured rat striatal neurons.
Topics: Animals; Calcium; Cell Survival; Cells, Cultured; Corpus Striatum; Cysteine Proteinase Inhibitors; Glutamic Acid; Glycoproteins; Hippocampus; Intracellular Space; Membrane Potential, Mitochondrial; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Time Factors | 2010 |
Nox4-dependent H2O2 production contributes to chronic glutamate toxicity in primary cortical neurons.
Topics: Animals; Base Sequence; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; DNA Primers; Glutamic Acid; Hydrogen Peroxide; Mice; N-Methylaspartate; NADPH Oxidase 4; NADPH Oxidases; Neurons; Reactive Oxygen Species; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA Interference; RNA, Small Interfering | 2010 |
Inhibitory avoidance memory deficit induced by scopolamine: Interaction of cholinergic and glutamatergic systems in the ventral tegmental area.
Topics: Acetylcholine; Animals; Avoidance Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Memory; Memory Disorders; Muscarinic Antagonists; N-Methylaspartate; Neuropsychological Tests; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Scopolamine; Ventral Tegmental Area | 2010 |
An excitatory loop with astrocytes contributes to drive neurons to seizure threshold.
Topics: 4-Aminopyridine; Action Potentials; Adenosine Triphosphate; Animals; Astrocytes; Calcium; Chelating Agents; Egtazic Acid; Entorhinal Cortex; Excitatory Amino Acid Agonists; Glutamic Acid; Guinea Pigs; Mice; Mice, Transgenic; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Rats, Wistar; Seizures | 2010 |
Differences in glutamate-mediated calcium responses in the ventral cochlear nucleus and inferior colliculus of the developing rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Auditory Pathways; Calcium; Calcium Signaling; Cochlear Nucleus; Glutamic Acid; Inferior Colliculi; Models, Animal; N-Methylaspartate; Neuronal Plasticity; Neurons; Rats; Rats, Wistar; Receptors, Glutamate | 2010 |
Neuron-astrocyte interactions in the medial nucleus of the trapezoid body.
Topics: Amino Acid Transport System X-AG; Animals; Anthozoa; Astrocytes; Brain Stem; Calcium; Cell Communication; Chelating Agents; Electric Stimulation; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Green Fluorescent Proteins; Membrane Potentials; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Serine; Synapses; Synaptic Transmission; Time Factors | 2010 |
Bcl11A/CTIP1 mediates the effect of the glutamate receptor on axon branching and dendrite outgrowth.
Topics: Animals; Axons; Carrier Proteins; Cell Enlargement; Cells, Cultured; DCC Receptor; Dendrites; Glutamic Acid; N-Methylaspartate; Nuclear Proteins; Rats; Receptors, Cell Surface; Receptors, Glutamate; Repressor Proteins; Signal Transduction; Tumor Suppressor Proteins; Zinc Fingers | 2010 |
Glutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus can modulate haloperidol-induced catalepsy.
Topics: 2-Amino-5-phosphonovalerate; Animals; Catalepsy; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Inferior Colliculi; Male; Microinjections; Motor Activity; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Statistics, Nonparametric; Synaptic Transmission | 2010 |
Retinal input to efferent target amacrine cells in the avian retina.
Topics: Action Potentials; Amacrine Cells; Animals; Chickens; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agents; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; In Vitro Techniques; Isoquinolines; Kainic Acid; Mesencephalon; N-Methylaspartate; Neurons; Nicotinic Agonists; Parvalbumins; Patch-Clamp Techniques; Receptors, Neurotransmitter; Retina; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Vesicular Glutamate Transport Protein 2; Visual Pathways | 2010 |
The antinociceptive effects of AR-A014418, a selective inhibitor of glycogen synthase kinase-3 beta, in mice.
Topics: Abdominal Pain; Aggression; Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azides; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Formaldehyde; Glutamic Acid; Glycogen Synthase Kinase 3; Inflammation; Male; Mice; N-Methylaspartate; Pain Measurement; Sugar Acids; Thiazoles; Urea; Xylose | 2011 |
Characterization of GFP-tagged GnRH-containing terminalis neurons in transgenic zebrafish.
Topics: Action Potentials; Animals; Animals, Genetically Modified; Axons; Cell Membrane; Gene Expression Regulation; Glutamic Acid; Gonadotropin-Releasing Hormone; Green Fluorescent Proteins; Kainic Acid; N-Methylaspartate; Neurons; Olfactory Bulb; Patch-Clamp Techniques; Receptors, Glutamate; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Zebrafish | 2011 |
Botulinum neurotoxin type A (BoNTA) decreases the mechanical sensitivity of nociceptors and inhibits neurogenic vasodilation in a craniofacial muscle targeted for migraine prophylaxis.
Topics: Analysis of Variance; Animals; Blotting, Western; Botulinum Toxins, Type A; Facial Muscles; Female; Glutamic Acid; Immunohistochemistry; N-Methylaspartate; Nerve Fibers; Nociceptors; Pain Threshold; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Substance P; Vasodilation | 2010 |
Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.
Topics: Animals; Binding, Competitive; Calcium Signaling; Cell Line, Tumor; Cell Membrane; Cerebral Cortex; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fluorometry; Glutamic Acid; Glycine; HEK293 Cells; Humans; Male; Molecular Structure; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Transfection | 2010 |
Neural mechanisms mediating circadian phase resetting by activation of 5-HT(7) receptors in the dorsal raphe: roles of GABAergic and glutamatergic neurotransmission.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bicuculline; Circadian Rhythm; Cricetinae; Dizocilpine Maleate; Drug Administration Schedule; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mesocricetus; Microinjections; Muscimol; N-Methylaspartate; Raphe Nuclei; Receptors, Serotonin; Serotonin Receptor Agonists; Synaptic Transmission | 2010 |
Inhibitory avoidance memory deficit induced by scopolamine: interaction with glutamatergic system in the nucleus accumbens.
Topics: Animals; Avoidance Learning; Cholinergic Antagonists; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Inhibition, Psychological; Male; Memory Disorders; Microinjections; N-Methylaspartate; Nucleus Accumbens; Rats; Rats, Wistar; Scopolamine | 2010 |
Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses.
Topics: Animals; Cell Differentiation; Dendrites; Dendritic Spines; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Mice; N-Methylaspartate; Neuronal Plasticity; Neurons; Synapses; Wnt Proteins; Wnt-5a Protein | 2010 |
Specific brainstem neurons switch each other into pacemaker mode to drive movement by activating NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Biological Clocks; Brain Stem; Cadmium Chloride; Dihydro-beta-Erythroidine; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; Glutamic Acid; Glycyrrhetinic Acid; Humans; In Vitro Techniques; Larva; Models, Biological; Movement; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Periodicity; Pyridazines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Swimming; Xenopus | 2010 |
[Relation between GLu-R and the protective effect of hypothermia on oxygen and glucose deprivation injury in hippocampal slice or rat].
Topics: Animals; Cell Hypoxia; Glucose; Glutamic Acid; Hippocampus; Hypothermia; Membrane Potentials; N-Methylaspartate; Neurons; Organ Culture Techniques; Oxygen; Rats; Rats, Sprague-Dawley | 2005 |
Microbiology. Another microbial pathway for acetate assimilation.
Topics: Acetates; Gene Transfer, Horizontal; Glutamic Acid; Glyoxylates; Haloarcula marismortui; Isocitrates; Metabolic Networks and Pathways; N-Methylaspartate; Succinic Acid | 2011 |
A methylaspartate cycle in haloarchaea.
Topics: Acetates; Acetyl Coenzyme A; Archaeal Proteins; Fumarates; Gene Transfer, Horizontal; Genes, Archaeal; Glutamic Acid; Glyoxylates; Haloarcula marismortui; Malates; Maleates; Metabolic Networks and Pathways; N-Methylaspartate; Oxidation-Reduction; Proteome; Succinic Acid | 2011 |
Cytosolic zinc release and clearance in hippocampal neurons exposed to glutamate--the role of pH and sodium.
Topics: Animals; Calcium; Cells, Cultured; Chelating Agents; Cytosol; Dose-Response Relationship, Drug; Edetic Acid; Embryo, Mammalian; Ethylenediamines; Excitatory Amino Acid Agonists; Fura-2; Glutamic Acid; Glycine; Hippocampus; Hydrogen-Ion Concentration; Mice; N-Methylaspartate; Neurons; Polycyclic Compounds; Sodium; Statistics, Nonparametric; Zinc | 2011 |
Enhanced NMDA receptor NR1 phosphorylation and neuronal activity in the arcuate nucleus of hypothalamus following peripheral inflammation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arcuate Nucleus of Hypothalamus; Blotting, Western; Dizocilpine Maleate; Glutamic Acid; Inflammation; Male; N-Methylaspartate; Phosphorylation; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2011 |
Frequency-dependent recruitment of fast amino acid and slow neuropeptide neurotransmitter release controls gonadotropin-releasing hormone neuron excitability.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Anterior Thalamic Nuclei; Biophysics; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Gonadotropin-Releasing Hormone; Green Fluorescent Proteins; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Neurons; Neuropeptides; Neurotransmitter Agents; Patch-Clamp Techniques; Reaction Time; Receptors, G-Protein-Coupled; Receptors, Kisspeptin-1; Statistics, Nonparametric; Synaptic Transmission; Valine | 2011 |
Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions.
Topics: Animals; Aspartic Acid; Calcium; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Hippocampus; Immunoprecipitation; Magnesium; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tetrahydronaphthalenes; Tritium | 2011 |
Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Brain; Brain Injuries; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Gene Expression; Genes, Reporter; Glutamic Acid; Luciferases; Male; Membrane Potentials; N-Methylaspartate; Neurons; Neuroprotective Agents; NFATC Transcription Factors; Nifedipine; Potassium; Progesterone; Rats; Rats, Sprague-Dawley | 2011 |
Allopregnanolone induces LHRH and glutamate release through NMDA receptor modulation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Estrogen Replacement Therapy; Female; Glutamic Acid; Gonadotropin-Releasing Hormone; Hypothalamus; In Vitro Techniques; Models, Animal; N-Methylaspartate; Neurotransmitter Agents; Ovariectomy; Pregnanolone; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2011 |
KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia.
Topics: Animals; Brain Ischemia; Calcium Signaling; Cell Culture Techniques; Cell Death; Cells, Cultured; Excitatory Amino Acid Agonists; Glutamic Acid; Indoles; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Neuroprotective Agents; Oximes; Small-Conductance Calcium-Activated Potassium Channels; Transcription, Genetic | 2011 |
Neuroprotection by NMDA preconditioning against glutamate cytotoxicity is mediated through activation of ERK 1/2, inactivation of JNK, and by prevention of glutamate-induced CREB inactivation.
Topics: Animals; Brain Ischemia; Cell Survival; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Excitatory Amino Acid Agonists; Glutamic Acid; Ischemic Preconditioning; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Primary Cell Culture; Rats; Reperfusion Injury | 2012 |
Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Brain Ischemia; Calcium; Cerebral Infarction; Cerebrosides; Charybdotoxin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glucose; Glutamic Acid; Hippocampus; Hypoxia; In Vitro Techniques; Infarction, Middle Cerebral Artery; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tetrazolium Salts; Valine | 2012 |
Glutamate racemization and catabolism in Fusobacterium varium.
Topics: Acetic Acid; Amino Acid Isomerases; Ammonia-Lyases; Bacterial Proteins; Butyrates; Carbon Isotopes; Chromatography, High Pressure Liquid; Cobalt; Cobamides; Fusobacterium; Glutamic Acid; Glutarates; Intramolecular Transferases; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Weight; N-Methylaspartate; Stereoisomerism | 2011 |
Enhanced role of adenosine A(2A) receptors in the modulation of LTP in the rat hippocampus upon ageing.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Aging; Animals; Electrophysiology; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Long-Term Potentiation; Male; Memory Disorders; N-Methylaspartate; Neuronal Plasticity; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Synaptic Transmission; Triazoles; Xanthines | 2011 |
[About the NMDA-system again].
Topics: Alcoholism; Alzheimer Disease; Animals; Antipsychotic Agents; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synapses | 2011 |
Differential modulation of the glutamate-nitric oxide-cyclic GMP pathway by distinct neurosteroids in cerebellum in vivo.
Topics: Animals; Cerebellum; Cyclic GMP; Dehydroepiandrosterone; gamma-Aminobutyric Acid; Glutamic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Nitric Oxide; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2011 |
Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Hippocampus; In Vitro Techniques; Inhalation Exposure; Interleukin-1alpha; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuroglia; Neurons; Particulate Matter; Rats; Receptors, AMPA; RNA, Messenger; Tumor Necrosis Factor-alpha; Vehicle Emissions | 2011 |
Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Ataxia; Cerebral Cortex; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Rats; Rats, Wistar; Reaction Time; Seizures; Spider Venoms; Synaptosomes; Tritium | 2011 |
Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay.
Topics: Animals; Cocaine; Glutamate Carboxypeptidase II; Glutamic Acid; Models, Animal; N-Methylaspartate; Organophosphorus Compounds; Pilocarpine; Planarians; Stereotyped Behavior | 2012 |
A β-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes.
Topics: Amyloid beta-Peptides; Animals; Calcium Channels, P-Type; Calcium Channels, Q-Type; Cells, Cultured; Female; Glutamic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Oocytes; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 2012 |
Coactivation of NMDA receptors by glutamate and D-serine induces dilation of isolated middle cerebral arteries.
Topics: Animals; Blotting, Western; Cells, Cultured; Denervation; Dose-Response Relationship, Drug; Drug Synergism; Endothelial Cells; Endothelium, Vascular; Fluorescent Antibody Technique; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Middle Cerebral Artery; Myography; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; Serine; Stereoisomerism; Vasodilation | 2012 |
Glutamate spillover promotes the generation of NMDA spikes.
Topics: Action Potentials; Animals; Animals, Newborn; Aspartic Acid; Biophysics; Calcium; Calcium Channel Blockers; Calcium Signaling; Chelating Agents; Dendrites; Drug Synergism; Egtazic Acid; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; In Vitro Techniques; Indoles; Male; Mice; N-Methylaspartate; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Quinoxalines; Statistics, Nonparametric | 2011 |
4-iodophenyl isothiocyanate: a neuroprotective compound.
Topics: 1-Methyl-4-phenylpyridinium; Analysis of Variance; Animals; Cells, Cultured; Cerebral Cortex; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Embryo, Mammalian; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glucose; Glutamic Acid; Herbicides; Hypoxia; Iodobenzenes; Isothiocyanates; L-Lactate Dehydrogenase; Monoamine Oxidase; N-Methylaspartate; Neurites; Neuroglia; Neurons; Neuroprotective Agents; Peroxides; Protein Binding; Rats; Rats, Wistar | 2012 |
Median preoptic nucleus and subfornical organ drive renal sympathetic nerve activity via a glutamatergic mechanism within the paraventricular nucleus.
Topics: 2-Amino-5-phosphonovalerate; Angiotensin II Type 1 Receptor Blockers; Animals; Bicuculline; Blood Pressure; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Glutamic Acid; Heart Rate; Kidney; Losartan; Male; N-Methylaspartate; Neurons; Paraventricular Hypothalamic Nucleus; Preoptic Area; Rats; Rats, Sprague-Dawley; Subfornical Organ; Sympathetic Nervous System | 2012 |
Dopamine-glutamate interplay in the ventral striatum modulates spatial learning in a receptor subtype-dependent manner.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Basal Ganglia; Behavior, Animal; Benzazepines; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exploratory Behavior; Glutamic Acid; Habituation, Psychophysiologic; Learning; Male; Mice; Motor Activity; N-Methylaspartate; Quinoxalines; Receptors, Dopamine; Space Perception; Sulpiride | 2012 |
Sex difference in stress-induced enhancement of hippocampal CA1 long-term depression during puberty.
Topics: Adrenalectomy; Androgens; Animals; Animals, Newborn; Aspartic Acid; CA1 Region, Hippocampal; Corticosterone; Dexamethasone; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glucocorticoids; Glutamic Acid; In Vitro Techniques; Long-Term Synaptic Depression; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Ovariectomy; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sex Characteristics; Statistics, Nonparametric; Stress, Psychological; Synaptosomes; Testosterone; Valine | 2012 |
Pre and post synaptic NMDA effects targeting Purkinje cells in the mouse cerebellar cortex.
Topics: Animals; Cerebellar Cortex; Electrophysiology; Glutamic Acid; Mice; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Purkinje Cells; Rats; Receptors, N-Methyl-D-Aspartate | 2012 |
D₁-NMDA receptor interactions in the rat nucleus accumbens change during adolescence.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Corpus Striatum; Dopamine; Dopamine Agonists; Glutamic Acid; N-Methylaspartate; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate | 2012 |
Ionotropic glutamate receptors in hypothalamic paraventricular and supraoptic nuclei mediate vasopressin and oxytocin release in unanesthetized rats.
Topics: Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microinjections; N-Methylaspartate; Oxytocin; Paraventricular Hypothalamic Nucleus; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Supraoptic Nucleus; Vasopressins | 2012 |
Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration.
Topics: Amino Acid Motifs; Anaphase-Promoting Complex-Cyclosome; Animals; Apoptosis; Cell Nucleus; Cells, Cultured; Glucosephosphate Dehydrogenase; Glutamic Acid; Glycolysis; Mutagenesis, Site-Directed; N-Methylaspartate; Neurons; Oxidative Stress; Pentose Phosphate Pathway; Phosphofructokinase-2; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA Interference; RNA, Small Interfering; Ubiquitin-Protein Ligase Complexes | 2012 |
Timing-dependent reduction in ethanol sedation and drinking preference by NMDA receptor co-agonist d-serine.
Topics: Alcohol Drinking; Alcoholic Intoxication; Analysis of Variance; Animals; Ethanol; Glutamic Acid; Glycine; Male; Mice; Motor Activity; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine; Time Factors | 2012 |
A mathematical model for astrocytes mediated LTP at single hippocampal synapses.
Topics: Animals; Astrocytes; Biophysics; Calcium; Electric Stimulation; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Long-Term Potentiation; Models, Biological; Models, Theoretical; N-Methylaspartate; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses | 2012 |
Delayed mitochondrial membrane potential disruption by ATP in cultured rat hippocampal neurons exposed to N-methyl-D-aspartate.
Topics: Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Glutamic Acid; Hippocampus; Membrane Potential, Mitochondrial; Mitochondria; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2012 |
Synaptic cell adhesion molecule-2 and collapsin response mediator protein-2 are novel members of the matrix metalloproteinase-9 degradome.
Topics: Animals; Blotting, Western; Cells, Cultured; Densitometry; Electrophoresis, Gel, Two-Dimensional; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Intercellular Signaling Peptides and Proteins; Male; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Microscopy, Electron; N-Methylaspartate; Nerve Tissue Proteins; Neural Cell Adhesion Molecules; Synaptosomes; Tandem Mass Spectrometry | 2012 |
NMDA receptors in the medial prefrontal cortex and the dorsal hippocampus regulate methamphetamine-induced hyperactivity and extracellular amino acid release in mice.
Topics: Amino Acids; Animals; Blotting, Western; Central Nervous System Stimulants; Excitatory Amino Acid Agonists; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Hyperkinesis; Kainic Acid; Male; Methamphetamine; Mice; Microdialysis; N-Methylaspartate; Neural Pathways; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Vesicular Glutamate Transport Protein 2 | 2012 |
Involvement of the glutamatergic system in the nociception induced intrathecally for a TRPA1 agonist in rats.
Topics: Acrolein; Animals; Calcium; Excitatory Amino Acid Antagonists; Glutamic Acid; Hot Temperature; In Vitro Techniques; Injections, Spinal; Male; Membranes; N-Methylaspartate; Nociception; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Spinal Cord; Synaptic Transmission; Synaptosomes; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2012 |
Glutamatergic input to the lateral hypothalamus stimulates ethanol intake: role of orexin and melanin-concentrating hormone.
Topics: Alcohol Drinking; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Glutamic Acid; Hypothalamic Area, Lateral; Hypothalamic Hormones; Intracellular Signaling Peptides and Proteins; Male; Melanins; N-Methylaspartate; Neuropeptides; Orexins; Pituitary Hormones; Rats; Rats, Sprague-Dawley | 2013 |
Induction of P-glycoprotein and Bcrp at the rat blood-brain barrier following a subchronic morphine treatment is mediated through NMDA/COX-2 activation.
Topics: Analysis of Variance; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood Vessels; Blood-Brain Barrier; Brain; Cell Line, Transformed; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glutamic Acid; Humans; Iloprost; Male; Meloxicam; Misoprostol; Morphine; N-Methylaspartate; Narcotics; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiazines; Thiazoles; Time Factors | 2012 |
Activity-dependent modulation of the interaction between CaMKIIα and Abi1 and its involvement in spine maturation.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphate; Animals; Calcium; Calcium Chloride; Calcium Ionophores; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Catalytic Domain; Cells, Cultured; Cerebral Cortex; Dendritic Spines; Embryo, Mammalian; Excitatory Amino Acid Agents; Glucose Transporter Type 1; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Humans; Immunoprecipitation; Iodine Isotopes; Ionomycin; N-Methylaspartate; Neurons; Phosphorylation; Protein Binding; Qa-SNARE Proteins; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Serine; SNARE Proteins; Synapses; Transfection; Vesicular Glutamate Transport Protein 1 | 2012 |
8-Hydroxycalamenene isolated from the rhizomes of Reynoutria elliptica exerts neuroprotective effects both in vitro and in vivo.
Topics: Animals; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Drug Evaluation, Preclinical; Fallopia japonica; Glutamic Acid; Glutathione; Male; Membrane Potential, Mitochondrial; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells; Rhizome; Sesquiterpenes | 2013 |
Chronic intermittent hypoxia depresses afferent neurotransmission in NTS neurons by a reduction in the number of active synapses.
Topics: Animals; Calcium; Data Interpretation, Statistical; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; Hypoxia, Brain; Male; N-Methylaspartate; Nerve Fibers; Neuronal Plasticity; Neurons, Afferent; Patch-Clamp Techniques; Rats; Rats, Wistar; Solitary Nucleus; Synapses; Synaptic Transmission | 2012 |
Effect of nafamostat on N-methyl-D-aspartate-induced retinal neuronal and capillary degeneration in rats.
Topics: Animals; Basement Membrane; Benzamidines; Capillaries; Diabetic Neuropathies; Excitatory Amino Acid Agonists; Glaucoma; Glutamic Acid; Guanidines; Intravitreal Injections; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Retinal Ganglion Cells; Retinal Neurons; Retinal Vessels; Serine Proteinase Inhibitors; Severity of Illness Index; Vascular Diseases | 2012 |
Protective role of STAT3 in NMDA and glutamate-induced neuronal death: negative regulatory effect of SOCS3.
Topics: Animals; bcl-X Protein; Cell Death; Cells, Cultured; Enzyme Inhibitors; Glutamic Acid; Humans; Interleukin-6; Janus Kinases; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins | 2012 |
Hyperammonemia alters the modulation by different neurosteroids of the glutamate-nitric oxide-cyclic GMP pathway through NMDA- GABAA - or sigma receptors in cerebellum in vivo.
Topics: Animals; Cerebellum; Citrulline; Cyclic GMP; Extracellular Space; Glutamic Acid; Hyperammonemia; Male; N-Methylaspartate; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 2013 |
Endogenous activation of presynaptic NMDA receptors enhances glutamate release from the primary afferents in the spinal dorsal horn in a rat model of neuropathic pain.
Topics: Animals; Behavior, Animal; Excitatory Postsynaptic Potentials; Glutamic Acid; Ligation; Male; N-Methylaspartate; Neuralgia; Posterior Horn Cells; Protein Kinase C; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Spinal Nerves; Synapses | 2013 |
Bimatoprost protects retinal neuronal damage via Akt pathway.
Topics: Amides; Animals; Antihypertensive Agents; Bimatoprost; Buthionine Sulfoximine; Cell Line; Cloprostenol; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Male; Mice; N-Methylaspartate; Oxidative Stress; Protective Agents; Proto-Oncogene Proteins c-akt; Retinal Ganglion Cells | 2013 |
Dexras1, a small GTPase, is required for glutamate-NMDA neurotoxicity.
Topics: Animals; Cerebral Cortex; Glutamic Acid; HEK293 Cells; Humans; Iron; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monomeric GTP-Binding Proteins; N-Methylaspartate; Nitric Oxide; PC12 Cells; ras Proteins; Rats; Retinal Ganglion Cells | 2013 |
Mechanistic and structural determinants of NMDA receptor voltage-dependent gating and slow Mg2+ unblock.
Topics: Biophysical Phenomena; Biophysics; Glutamic Acid; Glycine; Green Fluorescent Proteins; HEK293 Cells; Humans; Ion Channel Gating; Magnesium; Membrane Potentials; Models, Biological; N-Methylaspartate; Nerve Tissue Proteins; Patch-Clamp Techniques; Protein Conformation; Receptors, N-Methyl-D-Aspartate; Transfection | 2013 |
Inhibitory effects of acorn extract on glutamate-induced calcium signaling in cultured rat hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium Signaling; Cells, Cultured; Glutamic Acid; Hippocampus; N-Methylaspartate; Plant Extracts; Quercus; Rats; Rats, Sprague-Dawley | 2013 |
Protective effects of a compound isolated from Alnus japonica on oxidative stress-induced death in transformed retinal ganglion cells.
Topics: Alnus; Animals; Apoptosis; Buthionine Sulfoximine; Catechols; Cell Survival; Diarylheptanoids; DNA Nucleotidylexotransferase; Glaucoma; Glutamic Acid; In Situ Nick-End Labeling; Lipid Peroxidation; Male; N-Methylaspartate; Neuroprotective Agents; Nitroprusside; Oxidative Stress; Plant Extracts; Propidium; Rats; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells; Thiobarbituric Acid Reactive Substances | 2013 |
Enhanced asynchronous Ca(2+) oscillations associated with impaired glutamate transport in cortical astrocytes expressing Fmr1 gene premutation expansion.
Topics: Animals; Astrocytes; Ataxia; Biological Transport; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Dicarboxylic Acids; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Female; Fragile X Mental Retardation Protein; Fragile X Syndrome; Glutamic Acid; Kinetics; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Tremor; Trinucleotide Repeat Expansion | 2013 |
Neuronal transporter and astrocytic ATP exocytosis underlie activity-dependent adenosine release in the hippocampus.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphate; Animals; Astrocytes; Biosensing Techniques; CA1 Region, Hippocampal; Electric Stimulation; Exocytosis; Glutamic Acid; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microelectrodes; N-Methylaspartate; Nucleoside Transport Proteins; SNARE Proteins | 2013 |
Glycine transporter 1 modulates GABA release from amacrine cells by controlling occupancy of coagonist binding site of NMDA receptors.
Topics: Amacrine Cells; Animals; Axons; Binding Sites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fish Proteins; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Glycine Agents; Glycine Plasma Membrane Transport Proteins; Goldfish; Inhibitory Postsynaptic Potentials; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine; Strychnine | 2013 |
Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma.
Topics: Animals; Apoptosis; Binding Sites; Carrier Proteins; Cell Line; Disease Models, Animal; Excitatory Amino Acid Transporter 1; Glutamic Acid; Guanine Nucleotide Exchange Factors; HEK293 Cells; Humans; Low Tension Glaucoma; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Oxidative Stress; Phosphorylation; Protein Binding; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Degeneration; Retinal Ganglion Cells; Signal Transduction | 2013 |
A bionics chemical synapse.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Bionics; Computer Simulation; Electric Power Supplies; Electronics, Medical; Enzymes, Immobilized; Equipment Design; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Iontophoresis; Kinetics; Models, Theoretical; N-Methylaspartate; Synapses; Synaptic Transmission | 2013 |
Posttranslational nitration of tyrosine residues modulates glutamate transmission and contributes to N-methyl-D-aspartate-mediated thermal hyperalgesia.
Topics: Animals; Cytosol; Glutamic Acid; Glutamine; Hot Temperature; Hyperalgesia; Immunoprecipitation; Lumbar Vertebrae; Male; N-Methylaspartate; Nitrogen; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Synaptosomes; Tyrosine | 2013 |
Riluzole attenuates the effects of chemoconvulsants acting on glutamatergic and GABAergic neurotransmission in the planarian Dugesia tigrina.
Topics: Animals; Behavior, Animal; Convulsants; Dizocilpine Maleate; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Hyperkinesis; N-Methylaspartate; Planarians; Receptors, Glutamate; Riluzole; Semicarbazides; Synaptic Transmission | 2013 |
Selective inhibition by ethanol of mitochondrial calcium influx mediated by uncoupling protein-2 in relation to N-methyl-D-aspartate cytotoxicity in cultured neurons.
Topics: Animals; Calcium; Cell Line; Ethanol; Glutamic Acid; Humans; Ion Channels; Mice; Mitochondria; Mitochondrial Proteins; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Uncoupling Protein 2 | 2013 |
Force spectroscopy measurements show that cortical neurons exposed to excitotoxic agonists stiffen before showing evidence of bleb damage.
Topics: Animals; Blister; Cerebral Cortex; Elasticity; Glutamic Acid; Hypotonic Solutions; Microscopy, Atomic Force; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Sodium Channels; Spectrum Analysis; Time Factors; Veratridine | 2013 |
Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation.
Topics: Animals; Biological Availability; Brain; Calcium; Cell Hypoxia; Chlormethiazole; Chromatography, High Pressure Liquid; Excitatory Amino Acid Agonists; Female; GABA Agonists; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Oocytes; Pregnancy; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Xenopus laevis | 2014 |
Involvement of NMDA receptor in low-frequency magnetic field-induced anxiety in mice.
Topics: Animals; Anxiety; Bicuculline; Brain; Dizocilpine Maleate; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Magnetic Fields; Male; Maze Learning; Mice; Muscimol; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Social Behavior; Time Factors | 2014 |
Full-gestational exposure to nicotine and ethanol augments nicotine self-administration by altering ventral tegmental dopaminergic function due to NMDA receptors in adolescent rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blotting, Western; Central Nervous System Depressants; Chromatography, High Pressure Liquid; Dopaminergic Neurons; Electrochemistry; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Microinjections; N-Methylaspartate; Nicotine; Nicotinic Agonists; Polymerase Chain Reaction; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Self Administration; Ventral Tegmental Area | 2014 |
Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration.
Topics: Animals; Brain; Disks Large Homolog 4 Protein; Glutamic Acid; Guanylate Kinases; Kainic Acid; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Knockout; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Synapses | 2013 |
Locomotor rhythm generation linked to the output of spinal shox2 excitatory interneurons.
Topics: Animals; Axons; Dependovirus; Electrophysiological Phenomena; Excitatory Amino Acid Agonists; Gene Silencing; Glutamic Acid; Homeodomain Proteins; Immunohistochemistry; In Situ Hybridization; Interneurons; Locomotion; Male; Mice; Motor Neurons; N-Methylaspartate; Neural Pathways; Optogenetics; Serotonin; Spinal Cord; Vesicular Glutamate Transport Protein 2 | 2013 |
Father absence in the monogamous california mouse impairs social behavior and modifies dopamine and glutamate synapses in the medial prefrontal cortex.
Topics: Amphetamine; Animals; Behavior, Animal; Dopamine; Female; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Motor Activity; N-Methylaspartate; Paternal Deprivation; Prefrontal Cortex; Pyramidal Cells; Reward; Serotonin; Sex Factors; Social Behavior; Synapses; Synaptic Transmission | 2015 |
Variable dendritic integration in hippocampal CA3 pyramidal neurons.
Topics: Action Potentials; Animals; CA3 Region, Hippocampal; Dendrites; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Glutamic Acid; Male; N-Methylaspartate; Potassium Channels; Pyramidal Cells; Rats; Sodium | 2013 |
NMDA receptor activation antagonizes the NMDA antagonist-induced antianxiety effect in the elevated plus-maze test in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Binding Sites; Brain; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Ligands; Male; Maze Learning; Mice; N-Methylaspartate; Quinolones; Receptors, N-Methyl-D-Aspartate; Serine | 2013 |
Collapsin response mediator protein 2 (CRMP2) interacts with N-methyl-D-aspartate (NMDA) receptor and Na+/Ca2+ exchanger and regulates their functional activity.
Topics: Animals; Calcium; Calcium Signaling; Cells, Cultured; Cytosol; Electrophysiology; Gene Expression Regulation; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Homeostasis; Intercellular Signaling Peptides and Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Signal Transduction; Sodium-Calcium Exchanger | 2014 |
Stochastic hybrid model of spontaneous dendritic NMDA spikes.
Topics: Dendritic Spines; Glutamic Acid; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Sodium Channels; Stochastic Processes | 2014 |
Developmental changes in NMDA receptor subunit composition at ON and OFF bipolar cell synapses onto direction-selective retinal ganglion cells.
Topics: Age Factors; Animals; Animals, Newborn; Excitatory Amino Acid Agonists; Female; Gene Expression Regulation, Developmental; Glutamic Acid; Green Fluorescent Proteins; In Vitro Techniques; Light; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Neurotransmitter Agents; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Bipolar Cells; Retinal Ganglion Cells; Synapses; Visual Pathways | 2014 |
Glutamatergic neurotransmission in the inferior colliculus influences intrastriatal haloperidol-induced catalepsy.
Topics: Animals; Antipsychotic Agents; Catalepsy; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Inferior Colliculi; Male; N-Methylaspartate; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2014 |
Involvement of the nucleus accumbens shell glutamatergic system in ACPA-induced impairment of inhibitory avoidance memory consolidation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arachidonic Acids; Avoidance Learning; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Memory; Memory Disorders; Motor Activity; N-Methylaspartate; Nucleus Accumbens; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2014 |
Transient inactivation of the ventral hippocampus in neonatal rats impairs the mesolimbic regulation of prefrontal glutamate release in adulthood.
Topics: Animals; Animals, Newborn; Catheters, Indwelling; Disease Models, Animal; Electrodes, Implanted; Glutamic Acid; Hippocampus; Male; Microelectrodes; N-Methylaspartate; Nucleus Accumbens; Prefrontal Cortex; Rats, Wistar; Schizophrenia; Sodium Channel Blockers; Tetrodotoxin | 2014 |
Lack of hypocretin attenuates behavioral changes produced by glutamatergic activation of the perifornical-lateral hypothalamic area.
Topics: Animals; Arousal; Glutamic Acid; Hypothalamic Area, Lateral; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Knockout; N-Methylaspartate; Narcolepsy; Neurons; Neuropeptides; Orexins; Sleep; Wakefulness | 2014 |
Role of glutamate and advantages of combining memantine with a 5HT6 ligand in a model of depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Glutamic Acid; Ligands; Male; Memantine; Motor Activity; N-Methylaspartate; Piperazines; Prefrontal Cortex; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Sulfonamides; Swimming | 2014 |
Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via CaM kinase II signaling.
Topics: Animals; Animals, Newborn; Astrocytes; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Neural Inhibition; Neurons; Receptors, GABA-A; Signal Transduction; Synapses; Transforming Growth Factor beta; Vesicular Inhibitory Amino Acid Transport Proteins | 2014 |
Dentate gyrus-CA3 glutamate release/NMDA transmission mediates behavioral despair and antidepressant-like responses to leptin.
Topics: Animals; Antidepressive Agents; CA3 Region, Hippocampal; Dentate Gyrus; Depression; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Agents; Gene Expression Regulation; Glutamic Acid; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; N-Methylaspartate; Receptors, Leptin; RNA, Untranslated; Synapses; Synaptic Transmission; Wakefulness | 2015 |
Serine racemase regulated by binding to stargazin and PSD-95: potential N-methyl-D-aspartate-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (NMDA-AMPA) glutamate neurotransmission cross-talk.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biocatalysis; Calcium Channels; Cell Membrane; Disks Large Homolog 4 Protein; Female; Glutamic Acid; Guanylate Kinases; HEK293 Cells; Humans; Male; Membrane Proteins; Mice; Models, Biological; N-Methylaspartate; Protein Binding; Racemases and Epimerases; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2014 |
Neuroprotective effects of daphnetin against NMDA receptor-mediated excitotoxicity.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Brain Ischemia; Cerebral Cortex; Gene Expression Regulation; Glutamic Acid; Humans; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Primary Cell Culture; Proto-Oncogene Proteins c-bcl-2; Receptors, N-Methyl-D-Aspartate; Umbelliferones | 2014 |
A mechanistic study on urine retention in d-amphetamine addicts.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Amidines; Amphetamine-Related Disorders; Animals; Benzophenanthridines; Central Nervous System Stimulants; Chronic Disease; Colforsin; Dextroamphetamine; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Isoquinolines; N-Methylaspartate; Oxidants; Protein Kinase Inhibitors; Rats, Wistar; Reflex; Spinal Cord; Sulfonamides; Urinary Retention; Urination; Valine | 2014 |
Adenylyl cyclase subtype 1 is essential for late-phase long term potentiation and spatial propagation of synaptic responses in the anterior cingulate cortex of adult mice.
Topics: Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amines; Animals; Benzofurans; Cyclohexanecarboxylic Acids; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; In Vitro Techniques; Long-Term Potentiation; Male; Mice; N-Methylaspartate; Nerve Net; Quinolines; Synaptic Transmission; Time Factors | 2014 |
Glycine transporters type 1 inhibitor promotes brain preconditioning against NMDA-induced excitotoxicity.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Agonists; Fluoresceins; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Hippocampus; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurotoxicity Syndromes; Sarcosine; Time Factors; Tritium | 2015 |
Prenatal nicotine is associated with reduced AMPA and NMDA receptor-mediated rises in calcium within the laterodorsal tegmentum: a pontine nucleus involved in addiction processes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Female; Glutamic Acid; Humans; Mice; Motivation; N-Methylaspartate; Nicotine; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Substance-Related Disorders; Tegmentum Mesencephali | 2015 |
N-methyl-D-aspartate preconditioning prevents quinolinic acid-induced deregulation of glutamate and calcium homeostasis in mice hippocampus.
Topics: Animals; Calcium; D-Aspartic Acid; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Homeostasis; Male; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Quinolinic Acid; Seizures | 2015 |
Amygdalar neuronal activity mediates the cardiovascular responses evoked from the dorsolateral periaqueductal gray in conscious rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Arterial Pressure; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA-A Receptor Agonists; Glutamic Acid; Heart Rate; Male; Microinjections; Muscimol; N-Methylaspartate; Neurons; Periaqueductal Gray; Rats, Wistar; Receptors, GABA-A; Receptors, Glutamate | 2015 |
Interactions between serotonin and glutamate-nitric oxide pathways in zebrafish scototaxis.
Topics: 5-Hydroxytryptophan; Animals; Anxiety; Glutamic Acid; N-Methylaspartate; Nitric Oxide; Nitric Oxide Donors; Piperazines; Pyridines; Serotonin; Zebrafish | 2015 |
Heteromerization of ligand binding domains of N-methyl-D-aspartate receptor requires both coagonists, L-glutamate and glycine.
Topics: Animals; Glutamic Acid; Glycine; Ion Channel Gating; Ligands; Mice; Models, Molecular; N-Methylaspartate; Protein Multimerization; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate | 2015 |
Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes.
Topics: Aged; Aged, 80 and over; Aldehyde Dehydrogenase; Animals; Astrocytes; Cell Count; Cells, Cultured; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glaucoma; Glutamic Acid; Humans; Intraocular Pressure; Memantine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Mitochondria; Mitochondrial Dynamics; N-Methylaspartate; Optic Disk; Oxidoreductases Acting on CH-NH Group Donors; Retinal Ganglion Cells | 2015 |
Adenosine A1 receptor activation modulates N-methyl-d-aspartate (NMDA) preconditioning phenotype in the brain.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Behavior, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hippocampus; Locomotion; Male; Mice; Mice, Inbred Strains; Motor Activity; N-Methylaspartate; Purinergic P1 Receptor Agonists; Receptor, Adenosine A1; Xanthines | 2015 |
Lack of pulse and surge modes and glutamatergic stimulation of luteinising hormone release in Kiss1 knockout rats.
Topics: Animals; Female; Follicle Stimulating Hormone; Glutamic Acid; Kisspeptins; Luteinizing Hormone; Male; Mice, Knockout; N-Methylaspartate; Norepinephrine; Rats; Sexual Maturation | 2015 |
Stimulation of glutamate receptors in the ventral tegmental area is necessary for serotonin-2 receptor-induced increases in mesocortical dopamine release.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amphetamines; Animals; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microdialysis; N-Methylaspartate; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Serotonin, 5-HT2; Serotonin 5-HT2 Receptor Agonists; Valine; Ventral Tegmental Area | 2015 |
Interaction between NMDA glutamatergic and nitrergic enteric pathways during in vitro ischemia and reperfusion.
Topics: Animals; Enzyme Inhibitors; Glutamic Acid; Guinea Pigs; Ileum; Male; Myenteric Plexus; N-Methylaspartate; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitrites; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; RNA, Messenger | 2015 |
Glutamatergic transmission is involved in the long lasting sexual inhibition of sexually exhausted male rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Copulation; Dose-Response Relationship, Drug; Ejaculation; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Satiety Response; Sexual Behavior, Animal; Synaptic Transmission; Time Factors | 2015 |
Characterization of a Synthetic Steroid 24-keto-cholest-5-en-3β, 19-diol as a Neuroprotectant.
Topics: Animals; Animals, Newborn; Calcium; Cell Hypoxia; Cells, Cultured; Cerebellum; Cholestanols; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxygen; Rats; Rats, Sprague-Dawley | 2015 |
Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input.
Topics: Animals; Biological Transport, Active; Biotinylation; Calcium; Cell Membrane; Cells, Cultured; Chick Embryo; Chickens; Culture Media, Conditioned; Ependymoglial Cells; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression Profiling; Glutamic Acid; Kainic Acid; N-Methylaspartate; Protein Kinase C; Protein Kinase Inhibitors; Retina; RNA, Messenger; Tetradecanoylphorbol Acetate | 2015 |
Phenotype-dependent inhibition of glutamatergic transmission on nucleus accumbens medium spiny neurons by the abused inhalant toluene.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Enkephalins; Glutamic Acid; Immunohistochemistry; Inhalant Abuse; Long-Term Synaptic Depression; Morpholines; N-Methylaspartate; Neural Inhibition; Neurons; Nucleus Accumbens; Phenotype; Protein Precursors; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; RNA, Messenger; Solvents; Synaptic Transmission; Toluene | 2016 |
Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Extracellular Space; Glutamic Acid; Glycine; Hippocampus; Mice, Knockout; Microdialysis; N-Methylaspartate; Neurons; Racemases and Epimerases; Receptors, N-Methyl-D-Aspartate; Serine; Taurine | 2015 |
Coupling of ascorbate and nitric oxide dynamics in vivo in the rat hippocampus upon glutamatergic neuronal stimulation: a novel functional interplay.
Topics: Animals; Ascorbate Oxidase; Ascorbic Acid; Carbon; Carbon Fiber; Enzyme Inhibitors; Extracellular Space; Glutamic Acid; Hippocampus; Indazoles; Male; Microelectrodes; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2015 |
Alteration of the Centromedial Amygdala Glutamatergic Synapses by the BDNF Val66Met Polymorphism.
Topics: Animals; Brain-Derived Neurotrophic Factor; Central Amygdaloid Nucleus; Conditioning, Classical; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extinction, Psychological; Fear; Glutamic Acid; In Vitro Techniques; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Neurons; Piperidines; Polymorphism, Single Nucleotide; Synapses; Valine | 2015 |
Activity-dependent downregulation of M-Type (Kv7) K⁺ channels surface expression requires the activation of iGluRs/Ca²⁺/PKC signaling pathway in hippocampal neuron.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels, L-Type; Cations; Cell Membrane; Cells, Cultured; Glutamic Acid; Hippocampus; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Maze Learning; N-Methylaspartate; Neurons; Protein Kinase C; Rats, Sprague-Dawley; Receptors, Ionotropic Glutamate | 2015 |
Enhanced NMDA receptor-mediated modulation of excitatory neurotransmission in the dorsal vagal complex of streptozotocin-treated, chronically hyperglycemic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Male; Mice; Mice, Obese; N-Methylaspartate; Pentanoic Acids; Receptors, N-Methyl-D-Aspartate; Streptozocin; Vagus Nerve | 2015 |
Investigation of the GPR39 zinc receptor following inhibition of monoaminergic neurotransmission and potentialization of glutamatergic neurotransmission.
Topics: alpha-Methyltyrosine; Animals; Dopamine; Fenclonine; Frontal Lobe; Glutamic Acid; Hippocampus; Male; Mice; Mice, Knockout; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Receptors, G-Protein-Coupled; Serotonin; Synaptic Transmission; Tryptophan; Tyrosine; Zinc | 2015 |
Contribution of extrasynaptic N-methyl-D-aspartate and adenosine A1 receptors in the generation of dendritic glutamate-mediated plateau potentials.
Topics: Animals; Dendrites; Diazonium Compounds; Glutamic Acid; Mice; N-Methylaspartate; Piperidines; Prefrontal Cortex; Pyramidal Cells; Pyridines; Receptor, Adenosine A1; Receptors, N-Methyl-D-Aspartate; Synaptic Potentials | 2015 |
Small-molecule inhibitors at the PSD-95/nNOS interface protect against glutamate-induced neuronal atrophy in primary cortical neurons.
Topics: Analysis of Variance; Animals; Animals, Newborn; Atrophy; Cell Death; Cells, Cultured; Cerebral Cortex; Chlorophenols; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Guanylate Cyclase; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; N-Methylaspartate; Neurites; Neurons; Neuroprotective Agents; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitroprusside; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2015 |
Nitrous oxide directly inhibits action potential-dependent neurotransmission from single presynaptic boutons adhering to rat hippocampal CA3 neurons.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; CA3 Region, Hippocampal; Electric Stimulation; Female; GABAergic Neurons; gamma-Aminobutyric Acid; Glutamic Acid; Inhibitory Postsynaptic Potentials; Male; N-Methylaspartate; Nitrous Oxide; Presynaptic Terminals; Rats; Rats, Wistar; Synaptic Transmission | 2015 |
Synaptic mechanisms shaping delay-tuned combination-sensitivity in the auditory thalamus of mustached bats.
Topics: Acoustic Stimulation; Acoustics; Animals; Auditory Cortex; Chiroptera; Echolocation; Electrodes; gamma-Aminobutyric Acid; Geniculate Bodies; Glutamic Acid; Inferior Colliculi; Kainic Acid; N-Methylaspartate; Neurons; Reaction Time; Signal Processing, Computer-Assisted; Thalamus; Time Factors | 2016 |
Naturally occurring marine steroid 24-methylenecholestane-3β,5α,6β,19-tetraol functions as a novel neuroprotectant.
Topics: Animals; Aquatic Organisms; Brain Ischemia; Cerebral Cortex; Cholestanols; Glutamic Acid; Infarction, Middle Cerebral Artery; Magnetic Resonance Spectroscopy; Male; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley | 2016 |
L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade.
Topics: Adenosine Triphosphate; Animals; Cell Death; Cells, Cultured; Female; Glutamic Acid; Lactic Acid; Male; Mice; Mitochondria; Models, Biological; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxidation-Reduction; Phosphatidylinositol 3-Kinases; Potassium Channels; Receptors, Purinergic P2Y; Signal Transduction | 2016 |
PhTx3-4, a Spider Toxin Calcium Channel Blocker, Reduces NMDA-Induced Injury of the Retina.
Topics: Animals; Calcium Channel Blockers; Electroretinography; Glutamic Acid; Lipid Peroxidation; Male; N-Methylaspartate; Neuropeptides; Neuroprotective Agents; Rats, Wistar; Reactive Oxygen Species; Retinal Diseases; Spider Venoms; Vitreous Body | 2016 |
Differential involvement of glutamatergic and catecholaminergic activity within the amygdala during taste aversion retrieval on memory expression and updating.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amygdala; Animals; Avoidance Learning; Catecholamines; Cobalt; Conditioning, Psychological; Excitatory Amino Acid Agents; Exploratory Behavior; Glutamic Acid; Immobility Response, Tonic; Male; Mental Recall; Microdialysis; N-Methylaspartate; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Swimming; Taste | 2016 |
Gap Junctions Contribute to the Regulation of Walking-Like Activity in the Adult Mudpuppy (Necturus Maculatus).
Topics: Amphibian Proteins; Animals; Connexins; Gap Junctions; Glutamic Acid; N-Methylaspartate; Necturus; Nerve Net; Spine; Walking | 2016 |
Contribution of NMDA, GABAA and GABAB receptors and l-arginine-NO-cGMP, MEK1/2 and CaMK-II pathways in the antidepressant-like effect of 7-fluoro-1,3-diphenylisoquinoline-1-amine in mice.
Topics: Animals; Antidepressive Agents; Arginine; Biological Transport; Cyclic GMP; Glutamic Acid; Locomotion; Male; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; N-Methylaspartate; Nitric Oxide; Quinolines; Receptors, GABA-A; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2016 |
Inhibition of the pontine Kölliker-Fuse nucleus reduces genioglossal activity elicited by stimulation of the retrotrapezoid chemoreceptor neurons.
Topics: Animals; Chemoreceptor Cells; Diaphragm; Glutamate Decarboxylase; Glutamic Acid; Hypercapnia; Male; Medulla Oblongata; Muscimol; N-Methylaspartate; Neurotransmitter Agents; Pons; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Respiration; Tongue; Vesicular Glutamate Transport Protein 2 | 2016 |
The Bisphosphonates Clodronate and Etidronate Exert Analgesic Effects by Acting on Glutamate- and/or ATP-Related Pain Transmission Pathways.
Topics: Acetic Acid; Adenosine Triphosphate; Analgesics; Animals; Bone Density Conservation Agents; Capsaicin; Clodronic Acid; Etidronic Acid; Excitatory Amino Acid Agonists; Foscarnet; Glutamic Acid; Lumbar Vertebrae; Mice; Mice, Inbred BALB C; N-Methylaspartate; Pain; Sodium-Phosphate Cotransporter Proteins; Spinal Cord; Substance P | 2016 |
Nitric oxide modulates blood pressure through NMDA receptors in the rostral ventrolateral medulla of conscious rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arterial Pressure; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Heart Rate; Male; Medulla Oblongata; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred F344; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2016 |
Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity.
Topics: Amino Acid Transport System X-AG; Animals; Antineoplastic Agents; Aspartic Acid; Astrocytes; Cells, Cultured; Cerebral Cortex; Cytokines; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Glial Fibrillary Acidic Protein; Glutamic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Oncostatin M; Oncostatin M Receptor beta Subunit; Retroviridae Proteins, Oncogenic; Signal Transduction | 2016 |
AMPA/NMDA cooperativity and integration during a single synaptic event.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Excitatory Postsynaptic Potentials; Glutamic Acid; Humans; Models, Neurological; N-Methylaspartate; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses | 2016 |
Stimulation of the hypothalamic arcuate nucleus increases brown adipose tissue nerve activity via hypothalamic paraventricular and dorsomedial nuclei.
Topics: 2-Amino-5-phosphonovalerate; Adipose Tissue, Brown; alpha-MSH; Animals; Arcuate Nucleus of Hypothalamus; Dorsomedial Hypothalamic Nucleus; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Dyes; GABA-A Receptor Agonists; Glutamic Acid; Immunohistochemistry; Male; Microinjections; Muscimol; N-Methylaspartate; Neural Inhibition; Paraventricular Hypothalamic Nucleus; Pro-Opiomelanocortin; Quinoxalines; Rats; Rats, Wistar; Receptor, Melanocortin, Type 3; Receptor, Melanocortin, Type 4; Stilbamidines; Sympathetic Nervous System; Temperature; Thermogenesis; Vesicular Glutamate Transport Proteins | 2016 |
Glufosinate aerogenic exposure induces glutamate and IL-1 receptor dependent lung inflammation.
Topics: Aminobutyrates; Animals; Glutamic Acid; Herbicides; Humans; Interleukin-1beta; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nitric Oxide Synthase Type II; Peroxidase; Pneumonia; Receptors, Interleukin-1; Receptors, N-Methyl-D-Aspartate | 2016 |
Neuromuscular NMDA Receptors Modulate Developmental Synapse Elimination.
Topics: Age Factors; Animals; Animals, Newborn; Calcium; Dipeptides; Drug Delivery Systems; Excitatory Amino Acid Agents; Female; Glutamate Carboxypeptidase II; Glutamic Acid; Male; Mice; Microscopy, Confocal; Morpholinos; Muscle Fibers, Skeletal; N-Methylaspartate; Nerve Tissue Proteins; Neuromuscular Junction; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; S100 Proteins | 2016 |
Postnatal changes in glutamatergic inputs of jaw-closing motoneuron dendrites.
Topics: Animals; Animals, Newborn; Brain Stem; Dendrites; Drug Delivery Systems; Glutamic Acid; Lasers; Masseter Muscle; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neuroanatomical Tract-Tracing Techniques; Neurotransmitter Agents; Patch-Clamp Techniques; Rats, Wistar; Sodium Channel Blockers; Tetrodotoxin; Tissue Culture Techniques | 2016 |
Positive allosteric modulators of the α7 nicotinic acetylcholine receptor potentiate glutamate release in the prefrontal cortex of freely-moving rats.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Anilides; Animals; Choline; Excitatory Amino Acid Agonists; Glutamic Acid; Isoxazoles; Male; N-Methylaspartate; Nucleus Accumbens; Phenylurea Compounds; Prefrontal Cortex; Rats; Rats, Wistar | 2016 |
Nitric oxide-coupled signaling in odor elicited molecular events in the olfactory center of the terrestrial snail, Helix pomatia.
Topics: Animals; Cyclic GMP; Glutamic Acid; Helix, Snails; Models, Biological; N-Methylaspartate; Neurons; Nitric Oxide; Odorants; Olfactory Bulb; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2017 |
Glutamate Induces Blood-Brain Barrier Permeability through Activation of N-Methyl-D-Aspartate Receptors.
Topics: Blood-Brain Barrier; Glutamic Acid; Humans; N-Methylaspartate; Permeability; Receptors, N-Methyl-D-Aspartate | 2016 |
Glutamatergic modulation of noradrenaline release in the rat median preoptic area.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Male; Microdialysis; N-Methylaspartate; Norepinephrine; Preoptic Area; Quisqualic Acid; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2017 |
Excessive activation of ionotropic glutamate receptors induces apoptotic hair-cell death independent of afferent and efferent innervation.
Topics: Animals; Apoptosis; Glutamic Acid; Hair Cells, Auditory; Kainic Acid; Larva; N-Methylaspartate; Neurons, Afferent; Neurons, Efferent; Receptors, AMPA; Receptors, Ionotropic Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Zebrafish | 2017 |
NMDA Glutamate Receptor Antagonism and the Heritable Risk for Alcoholism: New Insights from a Study of Nitrous Oxide.
Topics: Alcoholism; Glutamic Acid; Humans; N-Methylaspartate; Nitrous Oxide; Receptors, N-Methyl-D-Aspartate | 2017 |
Extracellular Glutamate in the Nucleus Accumbens Is Nanomolar in Both Synaptic and Non-synaptic Compartments.
Topics: Animals; Aspartic Acid; Calcium Signaling; Cell Compartmentation; Extracellular Space; Female; Glutamic Acid; Male; N-Methylaspartate; Neurons; Nucleus Accumbens; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses | 2017 |
Dapoxetine induces neuroprotective effects against glutamate-induced neuronal cell death by inhibiting calcium signaling and mitochondrial depolarization in cultured rat hippocampal neurons.
Topics: Animals; Benzylamines; Calcium Signaling; Cell Death; Dose-Response Relationship, Drug; Extracellular Space; Female; Glutamic Acid; Hippocampus; Intracellular Space; Membrane Potential, Mitochondrial; Mitochondria; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Selective Serotonin Reuptake Inhibitors | 2017 |
The dietary constituent resveratrol suppresses nociceptive neurotransmission via the NMDA receptor.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Hyperalgesia; Iontophoresis; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Resveratrol; Sensory Receptor Cells; Stilbenes; Trigeminal Nucleus, Spinal | 2017 |
Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity.
Topics: Animals; Benzodiazepines; Clozapine; D-Aspartate Oxidase; Dose-Response Relationship, Drug; Enzyme Activation; Glutamic Acid; Humans; Male; Mice; Mice, Knockout; N-Methylaspartate; Olanzapine; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors | 2017 |
Oral administration of a specific kynurenic acid synthesis (KAT II) inhibitor attenuates evoked glutamate release in rat prefrontal cortex.
Topics: Administration, Oral; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Electrodes; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Heterocyclic Compounds, 3-Ring; Kynurenic Acid; Kynurenine; Male; Microdialysis; N-Methylaspartate; Neural Pathways; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Thiazolidinediones; Transaminases | 2017 |
Tuning excitability of the hypothalamus via glutamate and potassium channel coupling.
Topics: Glutamic Acid; Hypothalamus; N-Methylaspartate; Potassium Channels; Supraoptic Nucleus | 2017 |
An examination of the roles of glutamate and sex in latent inhibition: Relevance to the glutamate hypothesis of schizophrenia?
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Inhibition, Psychological; Male; N-Methylaspartate; Rats; Rats, Wistar; Schizophrenia; Schizophrenic Psychology; Sex Characteristics | 2017 |
Adolescent stress leads to glutamatergic disturbance through dopaminergic abnormalities in the prefrontal cortex of genetically vulnerable mice.
Topics: Age Factors; Animals; Antipsychotic Agents; Calcium-Calmodulin-Dependent Protein Kinases; Dopamine; Dopamine Agonists; Female; Glutamic Acid; Male; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Stress, Psychological | 2017 |
The role of glutamate in neuronal ion homeostasis: A case study of spreading depolarization.
Topics: Animals; Aspartic Acid; Astrocytes; Brain Diseases; Cell Size; Computational Biology; Electrophysiological Phenomena; Glutamic Acid; Homeostasis; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Models, Neurological; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Visual Cortex | 2017 |
"Silent" NMDA Synapses Enhance Motion Sensitivity in a Mature Retinal Circuit.
Topics: Acetylcholine; Animals; gamma-Aminobutyric Acid; Glutamic Acid; Mice; Motion Perception; N-Methylaspartate; Patch-Clamp Techniques; Receptors, AMPA; Retina; Retinal Bipolar Cells; Retinal Ganglion Cells; Signal Transduction; Synapses | 2017 |
Membrane cholesterol depletion in cortical neurons highlights altered NMDA receptor functionality in a mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; beta-Cyclodextrins; Cell Membrane; Cell Survival; Cholesterol; Disease Models, Animal; Electrophysiology; Female; Glutamic Acid; Humans; Male; Membrane Microdomains; Mice; Mice, Transgenic; Motor Neurons; N-Methylaspartate; Proteomics; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Superoxide Dismutase-1 | 2018 |
NRAP-1 Is a Presynaptically Released NMDA Receptor Auxiliary Protein that Modifies Synaptic Strength.
Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Gene Expression Regulation; Glutamic Acid; Interneurons; Ion Channel Gating; Membrane Proteins; Movement; Muscle Cells; Mutation; N-Methylaspartate; Nuclear Proteins; Oocytes; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA-Binding Proteins; Signal Transduction; Synapses; Xenopus | 2017 |
The GluN2A Subunit Regulates Neuronal NMDA receptor-Induced Microglia-Neuron Physical Interactions.
Topics: Animals; CA1 Region, Hippocampal; Dentate Gyrus; Female; Glutamic Acid; Male; Mice; Microglia; Microscopy, Fluorescence, Multiphoton; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Protein Subunits; Receptors, N-Methyl-D-Aspartate | 2018 |
De novo mutations in GRIN1 cause extensive bilateral polymicrogyria.
Topics: Animals; Child; Child, Preschool; DNA Mutational Analysis; Excitatory Amino Acid Agonists; Family Health; Female; Glutamic Acid; Glycine; HEK293 Cells; Humans; Infant; Magnetic Resonance Imaging; Male; Membrane Potentials; Models, Molecular; Mutagenesis; Mutation; N-Methylaspartate; Nerve Tissue Proteins; Patch-Clamp Techniques; Polymicrogyria; Rats; Receptors, N-Methyl-D-Aspartate; Transfection | 2018 |
The GluN2B subunit represents a major functional determinant of NMDA receptors in human induced pluripotent stem cell-derived cortical neurons.
Topics: Allosteric Regulation; Animals; Cerebral Cortex; CHO Cells; Cricetinae; Cricetulus; Electrophysiological Phenomena; Glutamic Acid; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; N-Methylaspartate; Neurons; Phenotype; Protein Subunits; Receptors, N-Methyl-D-Aspartate | 2018 |
Mesenchymal Stem Cell Protection of Neurons against Glutamate Excitotoxicity Involves Reduction of NMDA-Triggered Calcium Responses and Surface GluR1, and Is Partly Mediated by TNF.
Topics: Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Mesenchymal Stem Cells; Mice; N-Methylaspartate; Neurons; Protein Domains; Receptors, AMPA; Receptors, Glutamate; Tumor Necrosis Factor-alpha | 2018 |
Paradoxical kinesia induced by appetitive 50-kHz ultrasonic vocalizations in rats depends on glutamatergic mechanisms in the inferior colliculus.
Topics: Animals; Appetitive Behavior; Catalepsy; Diazepam; Disease Models, Animal; GABA Modulators; Glutamic Acid; Haloperidol; Inferior Colliculi; Male; N-Methylaspartate; Neurotransmitter Agents; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Ultrasonics; Vocalization, Animal | 2018 |
New Therapeutic Approaches in Pulmonary Arterial Hypertension: The Pantheon Is Getting Crowded.
Topics: Glutamic Acid; Humans; Hypertension, Pulmonary; N-Methylaspartate; Receptors, Glutamate; Vascular Remodeling | 2018 |
Fast changes of NMDA and AMPA receptor activity under acute hyperammonemia in vitro.
Topics: Animals; Astrocytes; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hyperammonemia; N-Methylaspartate; Neurons; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2018 |
Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamine; Animals; Behavior, Animal; Cocaine; Disease Models, Animal; Dopamine Agents; Dopaminergic Neurons; Glutamic Acid; Mice; Mice, Transgenic; N-Methylaspartate; Neuronal Plasticity; Nucleus Accumbens; Optogenetics; Patch-Clamp Techniques; Receptors, Dopamine D1; Substance-Related Disorders; Synaptic Transmission; Ventral Tegmental Area; Vesicular Glutamate Transport Protein 2 | 2018 |
Persistent Overexposure to N-Methyl-D-Aspartate (NMDA) Calcium-Dependently Downregulates Glutamine Synthetase, Aquaporin 4, and Kir4.1 Channel in Mouse Cortical Astrocytes.
Topics: Animals; Aquaporin 4; Astrocytes; Calcium; Cells, Cultured; Cerebral Cortex; Down-Regulation; Glutamate-Ammonia Ligase; Glutamic Acid; Mice, Inbred C57BL; N-Methylaspartate; Nerve Tissue Proteins; Potassium Channels, Inwardly Rectifying; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 2019 |
Low-Intensity Ultrasound Decreases Ischemia-Induced Edema by Inhibiting N-Methyl-d-Aspartic Acid Receptors.
Topics: Animals; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Hippocampus; Male; N-Methylaspartate; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Ultrasonography | 2018 |
Cystine/Glutamate Antiporter and Aripiprazole Compensate NMDA Antagonist-Induced Dysfunction of Thalamocortical L-Glutamatergic Transmission.
Topics: Acetylcysteine; Animals; Antiporters; Aripiprazole; Dizocilpine Maleate; Glutamic Acid; Male; Models, Biological; N-Methylaspartate; Perfusion; Prefrontal Cortex; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Synaptic Transmission; Thalamus | 2018 |
NMDA spikes mediate amplification of inputs in the rat piriform cortex.
Topics: Action Potentials; Animals; Calcium; Dendrites; Female; Glutamic Acid; Male; Models, Neurological; N-Methylaspartate; Nonlinear Dynamics; Olfactory Pathways; Piriform Cortex; Pyramidal Cells; Rats, Wistar; Synapses | 2018 |
Anti-N-Methyl-D-Aspartic Acid Receptor 2 (Anti-NR2) Antibody in Neuropsychiatric Lupus Serum Damages the Blood-Brain Barrier and Enters the Brain.
Topics: Animals; Autoantibodies; Biological Transport; Blood-Brain Barrier; Brain; Capillary Permeability; China; Disease Models, Animal; Electric Impedance; Endothelial Cells; Extracellular Space; Female; Glutamic Acid; Lupus Vasculitis, Central Nervous System; Male; Microvessels; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2019 |
Screening of novel 3α5β-neurosteroids for neuroprotective activity against glutamate- or NMDA-induced excitotoxicity.
Topics: Animals; Cells, Cultured; Glutamic Acid; N-Methylaspartate; Neurons; Neuroprotection; Neuroprotective Agents; Neurotransmitter Agents; Rats, Wistar; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate | 2019 |
Excitatory pathway engaging glutamate, calcineurin, and NFAT upregulates IL-4 in ischemic neurons to polarize microglia.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cell Hypoxia; Cerebral Cortex; Glutamic Acid; Interleukin-4; Microglia; N-Methylaspartate; Neurons; NFATC Transcription Factors; Rats; Rats, Sprague-Dawley; Tacrolimus; Transcription, Genetic; Up-Regulation | 2020 |
Simultaneous Live Imaging of Multiple Endogenous Proteins Reveals a Mechanism for Alzheimer's-Related Plasticity Impairment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disks Large Homolog 4 Protein; Female; Glutamic Acid; Hippocampus; Ionomycin; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Membrane Proteins; N-Methylaspartate; Neuronal Plasticity; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses | 2019 |
Transient synaptic potentiation in nucleus accumbens shell during refraining from cocaine seeking.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cocaine; Cues; Dendritic Spines; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Extinction, Psychological; Glutamic Acid; Mice; N-Methylaspartate; Neuronal Plasticity; Neurons; Nucleus Accumbens; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Potentials; Synaptic Transmission | 2020 |
Exposing immature hippocampal neurons to excitotoxins reveals distinct transcriptome and protein regulation with induction of common survival signaling pathways.
Topics: Animals; Apoptosis; Cells, Cultured; GABAergic Neurons; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurogenesis; Proteome; Rats; Signal Transduction; Transcriptome | 2019 |
Soluble Epoxide Hydrolase Inhibition Attenuates Excitotoxicity Involving 14,15-Epoxyeicosatrienoic Acid-Mediated Astrocytic Survival and Plasticity to Preserve Glutamate Homeostasis.
Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Astrocytes; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Epoxide Hydrolases; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hippocampus; Homeostasis; Kainic Acid; Lauric Acids; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 8; Models, Biological; N-Methylaspartate; Neuroglia; Neuronal Plasticity; Neurons; Neurotoxins; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Solubility | 2019 |
Artificial taste avoidance memory induced by coactivation of NMDA and β-adrenergic receptors in the amygdala.
Topics: Amygdala; Animals; Avoidance Learning; Cerebral Cortex; Conditioning, Classical; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Memory; N-Methylaspartate; Norepinephrine; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, N-Methyl-D-Aspartate; Saccharin; Taste | 2019 |
Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity.
Topics: Acyclic Monoterpenes; Animals; Apoptosis; Brain; Cell Respiration; Cyclooxygenase 2; Glutamic Acid; Lipid Peroxidation; Mice, Inbred C57BL; Mitochondria; N-Methylaspartate; Oxidative Stress; Protective Agents | 2019 |
Regulatory effects associated with changes in intracellular potassium level in susceptibility to mitochondrial depolarization and excitotoxicity.
Topics: Animals; Cytoplasm; Glutamic Acid; Minoxidil; Mitochondria; N-Methylaspartate; Neurons; Potassium | 2020 |
N-methyl-D-aspartate (NMDA) receptor expression and function is required for early chondrogenesis.
Topics: Animals; Calcium; Cell Proliferation; Cell Survival; Cells, Cultured; Chickens; Chondrogenesis; Glutamic Acid; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2019 |
A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling.
Topics: Animals; Bicuculline; Cells, Cultured; GABA-A Receptor Antagonists; Glutamic Acid; Glycine; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; MicroRNAs; N-Methylaspartate; Neurotoxins; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Ribonuclease III; Seizures; Signal Transduction; Specific Pathogen-Free Organisms; Subcellular Fractions; Transcriptome; Up-Regulation | 2020 |
Transcranial photoacoustic imaging of NMDA-evoked focal circuit dynamics in the rat hippocampus.
Topics: Animals; Glutamic Acid; Hippocampus; N-Methylaspartate; Neuroimaging; Photoacoustic Techniques; Rats; Receptors, N-Methyl-D-Aspartate | 2020 |
Angiotensin-II-mediated AT
Topics: Angiotensin II; Animals; Blood Pressure; Down-Regulation; Glutamic Acid; Hypertension; Medulla Oblongata; N-Methylaspartate; Rats; Receptor, Angiotensin, Type 1; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2020 |
Interactions between in vivo neuronal-glial markers, side of hippocampal sclerosis, and pharmacoresponse in temporal lobe epilepsy.
Topics: Adult; Anticonvulsants; Biomarkers; Case-Control Studies; Creatine; Drug Resistant Epilepsy; Epilepsy, Temporal Lobe; Female; Glutamic Acid; Hippocampus; Humans; Inositol; Magnetic Resonance Imaging; Male; Middle Aged; N-Methylaspartate; Neuroglia; Neuroimaging; Neurons; Proton Magnetic Resonance Spectroscopy; Sclerosis; Treatment Outcome; Young Adult | 2020 |
Astrocyte dysfunction increases cortical dendritic excitability and promotes cranial pain in familial migraine.
Topics: Animals; Astrocytes; Disease Models, Animal; Glutamic Acid; Headache; Mice; Migraine Disorders; N-Methylaspartate | 2020 |
[Effect of wrist-ankle acupuncture on the expression of glutamate and NMDA receptor of the spinal dorsal horn in rats with neuropathic pain].
Topics: Acupuncture Therapy; Animals; Glutamic Acid; Lower Extremity; N-Methylaspartate; Neuralgia; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Dorsal Horn; Upper Extremity | 2020 |
Glutamate, d-(-)-2-Amino-5-Phosphonopentanoic Acid, and
Topics: 2-Amino-5-phosphonovalerate; Animals; Buffers; Cells, Cultured; Chronic Pain; Glutamic Acid; Humans; Mice; N-Methylaspartate; Neurons; Oocytes; Patch-Clamp Techniques; Primary Cell Culture; Rats; Receptors, Glycine; Recombinant Proteins; Reproducibility of Results; Spinal Cord; Synapses; Synaptic Transmission; Xenopus laevis; Zinc | 2020 |
Glutamate and NMDA affect cell excitability and action potential dynamics of single cell of macrophyte Nitellopsis obtusa.
Topics: Action Potentials; Characeae; Glutamic Acid; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate | 2020 |
A Study of the Participation of NMDA Glutamate Receptors in the Mechanisms of Specific Anterograde Amnesia Reversion.
Topics: Amnesia; Amnesia, Anterograde; Animals; Avoidance Learning; Conditioning, Classical; Cycloserine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Helix, Snails; Memory; Memory, Long-Term; Memory, Short-Term; Models, Animal; N-Methylaspartate; Neuronal Plasticity; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Reproducibility of Results; Synapses | 2020 |
Central Ang II (Angiotensin II)-Mediated Sympathoexcitation: Role for HIF-1α (Hypoxia-Inducible Factor-1α) Facilitated Glutamatergic Tone in the Paraventricular Nucleus of the Hypothalamus.
Topics: Angiotensin II; Animals; Baroreflex; Glutamic Acid; Hypertension; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Male; N-Methylaspartate; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sympathetic Nervous System | 2021 |
Tumor Necrosis Factor α Receptor Type 1 Activation in the Hypothalamic Paraventricular Nucleus Contributes to Glutamate Signaling and Angiotensin II-Dependent Hypertension.
Topics: Angiotensin II; Animals; Glutamic Acid; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Paraventricular Hypothalamic Nucleus; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction | 2021 |
A human stem cell-derived test system for agents modifying neuronal N-methyl-D-aspartate-type glutamate receptor Ca
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Kainic Acid; N-Methylaspartate; Neural Stem Cells; Neurons; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2021 |
Quantum energy levels of glutamate modulate neural biophotonic signals.
Topics: Animals; Brain; Chloroplasts; Glutamic Acid; In Vitro Techniques; Male; Mice; N-Methylaspartate; Neurons; Photons; Photosynthesis; Quantum Theory; Receptors, N-Methyl-D-Aspartate; Spinacia oleracea; Thermodynamics | 2021 |
Repetitive optogenetic stimulation of glutamatergic neurons: An alternative to NMDA treatment for generating locomotor activity in spinalized zebrafish larvae.
Topics: Animals; Excitatory Amino Acid Agonists; Fatigue; Glutamic Acid; Locomotion; Models, Animal; Motor Neurons; N-Methylaspartate; Neurons; Optogenetics; Spinal Cord; Swimming; Zebrafish | 2021 |
Slack K
Topics: Action Potentials; Animals; Brain Diseases; Cell Death; Cells, Cultured; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Potassium Channels, Sodium-Activated; Signal Transduction | 2021 |
Visual Disfunction due to the Selective Effect of Glutamate Agonists on Retinal Cells.
Topics: Amacrine Cells; Animals; Apoptosis; Excitatory Amino Acid Agonists; Glutamic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Vision Disorders | 2021 |
Orai1 is a crucial downstream partner of group I metabotropic glutamate receptor signaling in dorsal horn neurons.
Topics: Animals; Calcium; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Mice; N-Methylaspartate; ORAI1 Protein; Posterior Horn Cells; Receptors, AMPA; Receptors, Metabotropic Glutamate; Signal Transduction | 2022 |
Long-term exposure to high glucose induces changes in the expression of AMPA receptor subunits and glutamate transmission in primary cultured cortical neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport; Cell Death; Cells, Cultured; Cerebral Cortex; Female; Glucose; Glutamic Acid; N-Methylaspartate; Neurons; Protein Subunits; Rats, Wistar; Receptors, AMPA; Synaptophysin; Synaptotagmins; Vesicular Glutamate Transport Protein 1 | 2022 |
Elevation of Extracellular Glutamate by Blockade of Astrocyte Glutamate Transporters Inhibits Cocaine Reinforcement in Rats via a NMDA-GluN2B Receptor Mechanism.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Cocaine; Cocaine-Related Disorders; Female; Glutamic Acid; Male; N-Methylaspartate; Nucleus Accumbens; Rats; Receptors, N-Methyl-D-Aspartate; Self Administration | 2022 |
Testing the Role of Glutamate NMDA Receptors in Peripheral Trigeminal Nociception Implicated in Migraine Pain.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Glutamic Acid; Male; Migraine Disorders; N-Methylaspartate; Nociception; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Trigeminal Ganglion | 2022 |
Extrasynaptic NMDA Receptors Bidirectionally Modulate Intrinsic Excitability of Inhibitory Neurons.
Topics: Animals; Female; GABAergic Neurons; Glutamic Acid; Male; Mice; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Synapses | 2022 |
Music alleviates pain perception in depression mouse models by promoting the release of glutamate in the hippocampus of mice to act on GRIK5.
Topics: Animals; Depression; Glutamic Acid; Hippocampus; Mice; Music; N-Methylaspartate; Pain; Pain Perception; Serotonin | 2022 |
Engineered Neutral Phosphorous Dendrimers Protect Mouse Cortical Neurons and Brain Organoids from Excitotoxic Death.
Topics: Animals; Brain; Cells, Cultured; Dendrimers; Glutamic Acid; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Organoids; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2022 |
N-Methyl-D-Aspartate (NMDA)-Type Glutamate Receptors and Demyelinating Disorders: A Neuroimmune Perspective.
Topics: Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Glutamic Acid; Humans; N-Methylaspartate; Neuromyelitis Optica; Receptors, N-Methyl-D-Aspartate | 2022 |
Effects of C5a and Receptor CD88 on Glutamate and N-Methyl-D-Aspartic Acid Receptor Expression in the Mouse Model of Optic Neuromyelitis.
Topics: Animals; Disease Models, Animal; Glutamic Acid; Humans; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuromyelitis Optica; Receptor, Anaphylatoxin C5a; Spinal Cord Injuries | 2022 |
Chronic Light-Distorted Glutamate-Cortisol Signaling, Behavioral and Histological Markers, and Induced Oxidative Stress and Dementia: An Amelioration by Melatonin.
Topics: Animals; Biomarkers; Circadian Rhythm; Dementia; Dextromethorphan; Glutamic Acid; Hydrocortisone; Light; Melatonin; Mifepristone; N-Methylaspartate; Oxidative Stress; Rats; Rats, Wistar | 2022 |
mGlu
Topics: Animals; Cognition; Dizocilpine Maleate; Glutamic Acid; Mice; N-Methylaspartate; Prefrontal Cortex; Receptors, Metabotropic Glutamate | 2022 |
Genetic inhibition of collapsin response mediator protein-2 phosphorylation ameliorates retinal ganglion cell death in normal-tension glaucoma models.
Topics: Animals; Disease Models, Animal; Glaucoma; Glutamic Acid; Intercellular Signaling Peptides and Proteins; Mice; N-Methylaspartate; Nerve Tissue Proteins; Phosphorylation; Retinal Ganglion Cells | 2022 |
Layer-specific distribution and expression pattern of AMPA- and NMDA-type glutamate receptors in the barrel field of the adult rat somatosensory cortex: a quantitative electron microscopic analysis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrons; Glutamic Acid; N-Methylaspartate; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex; Synapses | 2023 |
Impaired learning and memory generated by hyperthyroidism is rescued by restoration of AMPA and NMDA receptors function.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Hyperthyroidism; Long-Term Potentiation; Mice; N-Methylaspartate; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2022 |
Lumateperone-mediated effects on prefrontal glutamatergic receptor-mediated neurotransmission: A dopamine D
Topics: Animals; Antipsychotic Agents; Dopamine; Glutamic Acid; Heterocyclic Compounds, 4 or More Rings; Humans; N-Methylaspartate; Prefrontal Cortex; Rats; Receptors, Dopamine D1 | 2022 |
Gliotransmission of D-serine promotes thirst-directed behaviors in Drosophila.
Topics: Animals; Astrocytes; Drosophila; Glutamic Acid; N-Methylaspartate; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Serine; Synaptic Transmission; Thirst; Water | 2022 |
In vivo nanoscopic landscape of neurexin ligands underlying anterograde synapse specification.
Topics: Animals; Cell Adhesion Molecules, Neuronal; Epitopes; Glutamic Acid; Ligands; Membrane Proteins; Mice; N-Methylaspartate; Nerve Tissue Proteins; Receptors, AMPA; Receptors, Glutamate; Receptors, Presynaptic; Synapses | 2022 |
Neuroprotective effects of ergosterol against TNF-α-induced HT-22 hippocampal cell injury.
Topics: Antioxidants; Ergosterol; Glutamic Acid; Hippocampus; N-Methylaspartate; Neuroprotective Agents; Tumor Necrosis Factor-alpha | 2022 |
Rutin prevents seizures in kainic acid-treated rats: evidence of glutamate levels, inflammation and neuronal loss modulation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport Systems; Animals; Anti-Inflammatory Agents; Carbamazepine; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Hippocampus; HMGB1 Protein; Inflammation; Interleukin-10; Interleukin-1beta; Interleukin-6; Kainic Acid; N-Methylaspartate; Rats; Receptors, Interleukin-1; Rutin; Seizures; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2022 |
[Long-term neurological outcomes in premature children with excitotoxic brain damage].
Topics: Antibodies; Brain; Brain Injuries; Child; Female; Glutamic Acid; Humans; Infant; Infant, Newborn; Infant, Premature; Lactates; N-Methylaspartate; Pregnancy; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2022 |
Effects of high glutamate concentrations on mitochondria of human neuroblastoma SH-SY5Y cells.
Topics: Calcium; Glutamic Acid; Humans; Mitochondria; N-Methylaspartate; Neuroblastoma; Reactive Oxygen Species; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2023 |
Astaxanthin Protection against Neuronal Excitotoxicity via Glutamate Receptor Inhibition and Improvement of Mitochondrial Function.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antioxidants; Calcium; Glutamic Acid; Humans; Mitochondria; N-Methylaspartate; Neurodegenerative Diseases; Neurons; Reactive Oxygen Species; Receptors, AMPA; Receptors, Glutamate; Xanthophylls | 2022 |
GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1/RIP3/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma.
Topics: Animals; Apoptosis; Caspase 1; Eosine Yellowish-(YS); Glaucoma; Glutamic Acid; Glutathione; Hematoxylin; Inflammasomes; Interleukin-1beta; Lactate Dehydrogenases; Mice; N-Methylaspartate; Necroptosis; NLR Family, Pyrin Domain-Containing 3 Protein; Reactive Oxygen Species; Receptor-Interacting Protein Serine-Threonine Kinases; Retinal Ganglion Cells | 2022 |
The neuroprotective effect of melatonin in glutamate excitotoxicity of R28 cells and mouse retinal ganglion cells.
Topics: Animals; Glaucoma; Glutamic Acid; Melatonin; Mice; N-Methylaspartate; Neuroprotective Agents; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells | 2022 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnanolone; Pyrrolidonecarboxylic Acid; Rodentia; Spasm; Spasms, Infantile | 2023 |
Pharmacological Profile of MP-101, a Novel Non-racemic Mixture of R- and S-dimiracetam with Increased Potency in Rat Models of Cognition, Depression and Neuropathic Pain.
Topics: Animals; Cognition; D-Aspartic Acid; Depression; Glutamic Acid; N-Methylaspartate; Neuralgia; Rats | 2022 |
Different Forms of Disorder in NMDA-Sensitive Glutamate Receptor Cytoplasmic Domains Are Associated with Differences in Condensate Formation.
Topics: Brain; Glutamic Acid; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2022 |
Opposite Modulation of the NMDA Receptor by Glycine and S-Ketamine and the Effects on Resting State EEG Gamma Activity: New Insights into the Glutamate Hypothesis of Schizophrenia.
Topics: Biomarkers; Electroencephalography; Glutamic Acid; Humans; Ketamine; Male; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2023 |
The role of NMDA glutamate receptors in lung injury caused by chronic long-term intermittent hypobaric hypoxia.
Topics: Animals; Dizocilpine Maleate; Glutamic Acid; Hypoxia; Interleukin-6; Lung Injury; N-Methylaspartate; Oxidants; Oxidative Stress; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Tumor Necrosis Factor-alpha | 2023 |
[In vitro examination of N-methyl-D-aspartate type glutamate receptors in non-excitable cells].
Topics: Calcium; Glutamic Acid; Humans; Melanoma; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate | 2023 |
The role of NMDA glutamate receptors in the lateral habenula on morphine-induced conditioned place preference in rats.
Topics: Animals; Dizocilpine Maleate; Glutamic Acid; Habenula; Male; Morphine; N-Methylaspartate; Narcotics; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2023 |
Activation of Metabotropic Glutamate Receptor (mGlu
Topics: Animals; Dizocilpine Maleate; Glutamic Acid; Morris Water Maze Test; N-Methylaspartate; Receptors, Metabotropic Glutamate; Receptors, Muscarinic | 2023 |
Purified Native Protein Extracted from the Venom of Agelena orientalis Attenuates Memory Defects in the Rat Model of Glutamate-Induced Excitotoxicity.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Glutamic Acid; N-Methylaspartate; omega-Conotoxin GVIA; Peptides; Rats; Rats, Wistar | 2023 |
Sp1 mediated the inhibitory effect of glutamate on pulmonary surfactant synthesis.
Topics: Animals; Choline; Choline-Phosphate Cytidylyltransferase; Dizocilpine Maleate; Glutamic Acid; Lung Injury; N-Methylaspartate; Phosphatidylcholines; Pulmonary Surfactants; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sp1 Transcription Factor | 2023 |
[Glutamate and its ionotropic receptor agonists inhibit the response to acute hypoxia in carotid body of rats].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbon Dioxide; Carotid Body; Glutamic Acid; Hypoxia; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2023 |
Oxycodone withdrawal is associated with increased cocaine self-administration and aberrant accumbens glutamate plasticity in rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Opioid; Animals; Cocaine; Cocaine-Related Disorders; Glutamic Acid; N-Methylaspartate; Nucleus Accumbens; Oxycodone; Rats; Rats, Sprague-Dawley; Self Administration | 2024 |