Page last updated: 2024-08-22

n-methylaspartate and formaldehyde

n-methylaspartate has been researched along with formaldehyde in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (41.38)18.2507
2000's11 (37.93)29.6817
2010's4 (13.79)24.3611
2020's2 (6.90)2.80

Authors

AuthorsStudies
Berge, OG; Hole, K; Lund, A; Mjellem-Joly, N1
Coderre, TJ; Melzack, R1
Cowan, A; Larson, AA; Murray, CW1
Furness, LE; Horan, R; Maier, SF; Martinez, J; Watkins, LR; Wiertelak, EP1
Hunter, JC; Singh, L1
Malmberg, AB; Yaksh, TL1
Eisenberg, E; Strassman, AM; Vos, BP1
Manning, BH; Mayer, DJ1
Elliott, KJ; Inturrisi, CE; Shimoyama, M; Shimoyama, N1
Chen, P; Hua, XY; Marsala, M; Nagy, I; Phillips, E; Polgar, E; Urban, L; Webb, M; Wollaston, L; Yaksh, TL1
Manning, BH1
Nie, H; Qiao, JT; Wang, H; Zhang, RX1
Haddad, E; Hassan, A; Johns, RA; Tao, YX1
Davis, MA; Garry, MG; Malik, S; Yang, J; Yu, J1
Huh, IH; Lee, TS; Park, YH; Shin, CY; Sohn, UD1
Hazama, K; Kawamata, M; Kawamata, T; Nakayama, Y; Namiki, A; Omote, K1
Castro, GD; Castro, JA; de Layño, AM; Fanelli, SL; Gómez, MI; Valles, E1
Bogulavsky, J; Drake, CT; Gage, FH; Hegarty, D; Heinemann, SF; Horner, P; Inturrisi, CE; Jenab, S; Kaspar, BK; Kohno, T; Malkmus, S; Masuyama, T; Ohata, M; Sailer, AW; South, SM; Vissel, B; Woolf, CJ; Yaksh, TL1
Ahn, DK; Bae, YC; Choi, HS; Ju, JS; Jung, CY; Kim, SK; Lee, HJ1
Davis, AM; Inturrisi, CE; Monaghan, DT; Shimoyama, M; Shimoyama, N1
An, TH; Bae, HB; Choi, JI; Chung, SS; Chung, ST; Jeong, CY; Jeong, SW; Kim, CM; Kim, SJ; Yoo, KY; Yoon, MH1
Aburada, M; Kase, Y; Miyamoto, K; Suzuki, Y; Takeda, S; Watanabe, S; Yano, S; Yuzurihara, M1
Chen, T; Hong, Y; Hu, Z; Quirion, R1
Egea, J; Gadotti, VM; López, MG; Martins, DF; Mazzardo-Martins, L; Nascimento, FP; Rosa, AO; Santos, AR1
Chapman, H; Hao, B; Huang, JL; Koivisto, A; Kuokkanen, K; Pertovaara, A; Saarnilehto, M; Wang, YX; Wei, H1
Amaral, VC; Mendes-Gomes, J; Nunes-de-Souza, RL1
Battaglia, A; Cibert-Goton, V; Fredriksson, S; Gavazzi, I; Henkemeyer, M; Sears, T; Yuan, G1
Condés-Lara, M; González-Hernández, A; Martínez-Lorenzana, G; Pérez-Ortega, J; Tello-García, IA1
Akdağlı Ekici, A; Alagöz, A; Ayaz, E; Doğan, G; Karaca, O; Kayır, S; Özcan, O; Yağan, Ö; Yalvaç, M; Zengin, EN; Zengin, M1

Trials

1 trial(s) available for n-methylaspartate and formaldehyde

ArticleYear
Neuroprotective effects of amantadine for experimental acute carbon monoxide poisoning.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:19

    Topics: Amantadine; Animals; Antioxidants; Arginine; Carbon Monoxide; Carbon Monoxide Poisoning; Catalase; D-Aspartic Acid; Formaldehyde; N-Methylaspartate; Neuroprotective Agents; Nitric Oxide; Paraffin; Rats; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase

2022

Other Studies

28 other study(ies) available for n-methylaspartate and formaldehyde

ArticleYear
Intrathecal co-administration of substance P and NMDA augments nociceptive responses in the formalin test.
    Pain, 1992, Volume: 51, Issue:2

    Topics: Animals; Formaldehyde; Injections, Spinal; Male; Mice; N-Methylaspartate; Nociceptors; Pain; Pain Measurement; Substance P

1992
The role of NMDA receptor-operated calcium channels in persistent nociception after formalin-induced tissue injury.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1992, Volume: 12, Issue:9

    Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dizocilpine Maleate; Formaldehyde; Injections, Subcutaneous; N-Methylaspartate; Nociceptors; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Skin

1992
Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model.
    Pain, 1991, Volume: 44, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Naloxone; Nociceptors; Pain; Peptide Fragments; Reaction Time; Substance P; Urethane

1991
Subcutaneous formalin produces centrifugal hyperalgesia at a non-injected site via the NMDA-nitric oxide cascade.
    Brain research, 1994, Jun-27, Volume: 649, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Cordotomy; Formaldehyde; Hot Temperature; Hyperalgesia; Injections, Spinal; Injections, Subcutaneous; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord

1994
Role of excitatory amino acid receptors in the mediation of the nociceptive response to formalin in the rat.
    Neuroscience letters, 1994, Jun-20, Volume: 174, Issue:2

    Topics: Analgesics; Animals; Formaldehyde; Inflammation; Male; N-Methylaspartate; Nociceptors; Pain Measurement; Pipecolic Acids; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate

1994
Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats.
    Pain, 1993, Volume: 54, Issue:3

    Topics: Analgesics; Animals; Arginine; Behavior, Animal; Formaldehyde; Hot Temperature; Injections, Spinal; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord

1993
The NMDA antagonist Memantine blocks pain behavior in a rat model of formalin-induced facial pain.
    Pain, 1993, Volume: 54, Issue:3

    Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Facial Pain; Formaldehyde; Grooming; Male; Memantine; N-Methylaspartate; Pain Measurement; Rats; Rats, Sprague-Dawley

1993
The central nucleus of the amygdala contributes to the production of morphine antinociception in the formalin test.
    Pain, 1995, Volume: 63, Issue:2

    Topics: Amygdala; Analgesics, Opioid; Animals; Brain Mapping; Formaldehyde; Hindlimb; Injections; Male; Morphine; N-Methylaspartate; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Time Factors

1995
d-Methadone is antinociceptive in the rat formalin test.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:2

    Topics: Analgesics, Opioid; Animals; Formaldehyde; Male; Methadone; N-Methylaspartate; Naloxone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereoisomerism

1997
Spinal neurokinin NK1 receptor down-regulation and antinociception: effects of spinal NK1 receptor antisense oligonucleotides and NK1 receptor occupancy.
    Journal of neurochemistry, 1998, Volume: 70, Issue:2

    Topics: Animals; Down-Regulation; Formaldehyde; Indoles; Injections, Spinal; Isoindoles; Male; N-Methylaspartate; Oligonucleotides, Antisense; Pain; Pain Threshold; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P

1998
A lateralized deficit in morphine antinociception after unilateral inactivation of the central amygdala.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Nov-15, Volume: 18, Issue:22

    Topics: Afferent Pathways; Amygdala; Animals; Behavior, Animal; Disinfectants; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fear; Formaldehyde; GABA Agonists; Hindlimb; Hyperalgesia; Locomotion; Male; Morphine; Muscimol; N-Methylaspartate; Narcotics; Nociceptors; Pain; Rats; Rats, Sprague-Dawley

1998
Peripheral nitric oxide contributes to both formalin- and NMDA-induced activation of nociceptors: An immunocytochemical study in rats.
    Journal of neuroscience research, 1999, Sep-15, Volume: 57, Issue:6

    Topics: Animals; Arginine; Enzyme Inhibitors; Formaldehyde; Immunohistochemistry; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nociceptors; Rats; Rats, Wistar

1999
Expression and action of cyclic GMP-dependent protein kinase Ialpha in inflammatory hyperalgesia in rat spinal cord.
    Neuroscience, 2000, Volume: 95, Issue:2

    Topics: Animals; Antibodies; Behavior, Animal; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formaldehyde; Guanylate Cyclase; Hyperalgesia; Male; Myelitis; N-Methylaspartate; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nociceptors; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord; Thionucleotides

2000
Knock down of spinal NMDA receptors reduces NMDA and formalin evoked behaviors in rat.
    Neuroreport, 2000, Jan-17, Volume: 11, Issue:1

    Topics: Animals; Behavior, Animal; Blotting, Western; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Formaldehyde; Hyperalgesia; Immunohistochemistry; Injections, Spinal; Male; N-Methylaspartate; Oligonucleotides, Antisense; Pain; Pain Measurement; PC12 Cells; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord

2000
The role of nitric oxide and prostaglandin E2 on the hyperalgesia induced by excitatory amino acids in rats.
    The Journal of pharmacy and pharmacology, 2000, Volume: 52, Issue:4

    Topics: Animals; Dinoprostone; Dizocilpine Maleate; Excitatory Amino Acids; Formaldehyde; Hyperalgesia; Indomethacin; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Time Factors

2000
Activation of peripheral NMDA-nitric oxide cascade in formalin test.
    Anesthesiology, 2000, Volume: 93, Issue:1

    Topics: Animals; Chromatography, High Pressure Liquid; Disinfectants; Enzyme Inhibitors; Formaldehyde; Injections, Subcutaneous; Male; Microdialysis; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve

2000
Alcohol induction of liver nuclear ethanol and N-nitrosodimethylamine metabolism to reactive metabolites.
    Teratogenesis, carcinogenesis, and mutagenesis, 2002, Volume: 22, Issue:2

    Topics: Acetaldehyde; Animals; Biotransformation; Carbon Isotopes; Cell Nucleus; Chronic Disease; Cytochrome P-450 CYP2E1; Diet; Dimethylnitrosamine; DNA; Ethanol; Formaldehyde; Lipid Metabolism; Liver; Male; Microsomes, Liver; N-Methylaspartate; NADP; Rats; Rats, Sprague-Dawley

2002
A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Jun-15, Volume: 23, Issue:12

    Topics: Animals; Binding Sites; Dependovirus; Excitatory Postsynaptic Potentials; Female; Formaldehyde; Genetic Vectors; Hyperalgesia; In Vitro Techniques; Integrases; Introns; Lumbosacral Region; Male; Mice; Mice, Mutant Strains; Motor Activity; N-Methylaspartate; Pain; Pain Measurement; Patch-Clamp Techniques; Posterior Horn Cells; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Transduction, Genetic; Viral Proteins

2003
Intracisternal NMDA produces analgesia in the orofacial formalin test of freely moving rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 2004, Volume: 28, Issue:3

    Topics: Analgesics; Animals; Behavior, Animal; Cisterna Magna; Excitatory Amino Acid Agonists; Face; Formaldehyde; Injections; Male; Microinjections; N-Methylaspartate; Naloxone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Vibrissae

2004
An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception, hyperalgesia, and morphine tolerance.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:2

    Topics: Analgesics, Opioid; Animals; Autoradiography; Behavior, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formaldehyde; Glycine; Hyperalgesia; Indoles; Injections, Spinal; Morphine; N-Methylaspartate; Narcotics; Oligonucleotides, Antisense; Pain; Pain Measurement; Rats; Reaction Time; Receptors, N-Methyl-D-Aspartate; RNA Probes; RNA, Messenger; Spinal Cord

2005
Evaluation of interaction between intrathecal adenosine and MK801 or NBQX in a rat formalin pain model.
    Pharmacology, 2005, Volume: 75, Issue:3

    Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Disease Models, Animal; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Formaldehyde; Injections, Spinal; Male; N-Methylaspartate; Pain; Quinoxalines; Rats; Rats, Sprague-Dawley

2005
Antinociceptive effect of methyleugenol on formalin-induced hyperalgesia in mice.
    European journal of pharmacology, 2006, Dec-28, Volume: 553, Issue:1-3

    Topics: Anesthetics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cyclooxygenase 1; Cyclooxygenase 2; Diclofenac; Eugenol; Excitatory Amino Acid Agonists; Formaldehyde; GABA Agonists; Hyperalgesia; Male; Mice; Muscimol; N-Methylaspartate; Nociceptors

2006
Modulation of NMDA receptors by intrathecal administration of the sensory neuron-specific receptor agonist BAM8-22.
    Neuropharmacology, 2008, Volume: 54, Issue:5

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Excitatory Amino Acid Agonists; Formaldehyde; Gene Expression Regulation; Male; N-Methylaspartate; NADP; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Cytoplasmic and Nuclear; Receptors, N-Methyl-D-Aspartate; Sensory Receptor Cells

2008
The antinociceptive effects of AR-A014418, a selective inhibitor of glycogen synthase kinase-3 beta, in mice.
    The journal of pain, 2011, Volume: 12, Issue:3

    Topics: Abdominal Pain; Aggression; Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azides; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Formaldehyde; Glutamic Acid; Glycogen Synthase Kinase 3; Inflammation; Male; Mice; N-Methylaspartate; Pain Measurement; Sugar Acids; Thiazoles; Urea; Xylose

2011
Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat.
    Pain, 2011, Volume: 152, Issue:3

    Topics: Acetanilides; Analysis of Variance; Animals; Ankyrins; Calcium Channels; Capsaicin; Cholecystokinin; Cinnamomum zeylanicum; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Hyperalgesia; Male; N-Methylaspartate; Pain Measurement; Peripheral Nervous System Diseases; Purines; Rats; Rats, Wistar; Sleep Deprivation; Spinal Cord; TRPA1 Cation Channel; TRPC Cation Channels

2011
Ventrolateral periaqueductal gray lesion attenuates nociception but does not change anxiety-like indices or fear-induced antinociception in mice.
    Behavioural brain research, 2011, Jun-01, Volume: 219, Issue:2

    Topics: Animals; Anxiety; Behavior, Animal; Excitatory Amino Acid Agonists; Fear; Formaldehyde; Male; Maze Learning; Mice; N-Methylaspartate; Nociceptors; Pain; Pain Measurement; Periaqueductal Gray

2011
Involvement of EphB1 receptors signalling in models of inflammatory and neuropathic pain.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Animals; Carrageenan; Cell Count; Disease Models, Animal; Electrophysiological Phenomena; Female; Formaldehyde; Gene Deletion; Gene Expression Regulation; Gene Knockout Techniques; Hyperalgesia; Inflammation; Locomotion; Male; Mice; N-Methylaspartate; Neuralgia; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Receptor, EphB1; Sciatic Nerve; Signal Transduction

2013
Oxytocin prevents neuronal network pain-related changes on spinal cord dorsal horn in vitro.
    Cell calcium, 2020, Volume: 90

    Topics: Animals; Animals, Newborn; Calcium; Female; Formaldehyde; Male; N-Methylaspartate; Nerve Net; Neuralgia; Neurons; Oxytocin; Spinal Cord Dorsal Horn

2020