Page last updated: 2024-08-22

n-methylaspartate and dextromethorphan

n-methylaspartate has been researched along with dextromethorphan in 55 studies

Research

Studies (55)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (10.91)	18.7374
1990's	30 (54.55)	18.2507
2000's	13 (23.64)	29.6817
2010's	3 (5.45)	24.3611
2020's	3 (5.45)	2.80

Authors

Authors	Studies
Carrozza, DP; Ferraro, TN; Golden, GT; Hare, TA; Reyes, PF	1
el-Asrar, AM; Maimone, D; Morse, PH; Reder, AT; Torczynski, E	1
Albers, GW; Moses, JA; Sáenz, RE	1
Calder, LD; Karler, R	1
Baimbridge, KG; Church, J; Shacklock, JA	1
Huang, JC; Marshall, J; Salt, TE; Voaden, MJ	1
Choi, DW; Regan, RF	1
Lo, EH; Steinberg, GK; Sun, GH	1
Apland, JP; Braitman, DJ	1
Aram, JA; Lodge, D; Martin, D; Millar, J; Pohler, G; Tomczyk, M; Zeman, S	1
Balázs, R; Cotman, CW; Hack, N; Jørgensen, OS	1
DeLaPaz, R; Kunis, D; Saleh, J; Steinberg, GK; Zarnegar, SR	1
Choi, DW; Coulter, DA; Prince, DA; Wong, BY	1
Borosky, SA; Clissold, DB; Ferkany, JW; Pontecorvo, MJ	1
Kunis, D; Saleh, J; Steinberg, GK	1
Herrera, AJ; Osborne, NN	1
Netzer, R; Pflimlin, P; Trube, G	1
Grant, GA; Kunis, DM; Maier, CM; Steinberg, GK; Sun, GH; Yoon, EJ	1
Carter, C; Fage, D; Nankai, M	1
Newman, AH; Robles, L; Tortella, FC; Witkin, JM	1
Blin, O; Fabre, N; Montastruc, JL; Rascol, O; Senard, JM	1
Block, F; Schwarz, M	2
Ginsberg, MD	1
Dickenson, AH	1
Debus, O; Kurlemann, G; Schuierer, G	1
Haberecht, MF; Lo, GJ; Mitchell, CK; Redburn, DA	1
Arnold, GL; Griebel, ML; Kearns, GL; Koroma, DM; Valentine, JL	1
Andaloro, VJ; Monaghan, DT; Rosenquist, TH	1
Allaz, AF; Dayer, P; Desmeules, J; Oestreicher, MK; Piguet, V	1
Blanchet, PJ; Chase, TN; Del Dotto, P; Natté, R; van den Munckhof, P; Verhagen Metman, L	1
Polifka, JE; Shepard, TH	1
Brent, RL	1
Amabeoku, GJ	1
Kim, HS; Kim, SH; Son, YR	1
Henderson, DJ; Morrison, LM; Wilson, JA; Withington, BS	1
Bütefisch, CM; Classen, J; Cohen, LG; Davis, BC; Kopylev, L; Sawaki, L; Wise, SP	1
Su, CH; Tao, PL; Wu, YH; Yeh, GC	1
Ben-Abraham, R; Weinbroum, AA	1
Calzada, JI; Johnson, DA; Jones, BE; Netland, PA	1
Adler, MW; Cowan, A; Geller, EB; Rawls, SM; Tallarida, RJ	1
Baker, AK; Hoffmann, VL; Meert, TF	1
Sun, W; Wessinger, WD	1
Bobo, WV; Fulton, RB	1
Allen, RM; Carelli, RM; Dykstra, LA; Everett, CV; Suchey, TL	1
Hansen, SN; Schlenker, EH	1
Lomas, LM; Picker, MJ; Terner, JM	1
Berger, SP; Brudney, EG; Johnson, SW; Meshul, CK; Paquette, MA; Putterman, DB	1
Carlsson, C; Chen, D; Harakal, C; Kamel, IR; Wendling, KS; Wendling, WW	1
Canning, BJ; Hilton, ECY; Saulsberry, L; Smith, JA	1
Chabert, J; Daali, Y; Dayer, P; Desmeules, JA; Ehret, GB; Forster, A; Fritschy, D; Gex-Fabry, M; Moursli, F; Piguet, V; Rebsamen, M; Rossier, MF; Wolff, A	1
Chen, HC; Chiu, CH; Huang, YS; Kang, HH; Li, IH; Liu, CT; Ma, KH; Shih, JH; Shiue, CY; Wang, CH	1
Cerne, R; Izenwasser, S; Newman, AH; Smith, JL; Tortella, FC; Witkin, JM	1
Aljabali, AAA; Chellappan, DK; Dua, K; Goyal, R; Sarena, P; Sharma, A; Taliyan, R; Tambuwala, MM; Urmera, MT	1
Schatzberg, AF	1

Reviews

3 review(s) available for n-methylaspartate and dextromethorphan

Article	Year
Emerging strategies for the treatment of ischemic brain injury. Research publications - Association for Research in Nervous and Mental Disease, 1993, Volume: 71 Topics: Animals; Benzazepines; Body Temperature; Brain; Brain Injuries; Brain Ischemia; Calcium Channel Blockers; Dextromethorphan; Dizocilpine Maleate; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; N-Methylaspartate	1993
Neurophysiology of opioid poorly responsive pain. Cancer surveys, 1994, Volume: 21 Topics: Analgesics, Opioid; Animals; Central Nervous System; Clonidine; Dextromethorphan; Dextrorphan; Dynorphins; Humans; Morphine; N-Methylaspartate; Neoplasms; Neurophysiology; Neuroprotective Agents; Pain; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Sympatholytics	1994
Dextromethorphan and dexmedetomidine: new agents for the control of perioperative pain. The European journal of surgery = Acta chirurgica, 2001, Volume: 167, Issue:8 Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Dexmedetomidine; Dextromethorphan; Humans; N-Methylaspartate; Pain; Pain, Postoperative; Premedication; Receptors, Adrenergic, alpha-2; Receptors, N-Methyl-D-Aspartate	2001

Trials

5 trial(s) available for n-methylaspartate and dextromethorphan

Article	Year
Tolerability of oral dextromethorphan in patients with a history of brain ischemia. Clinical neuropharmacology, 1992, Volume: 15, Issue:6 Topics: Aged; Brain Ischemia; Dextromethorphan; Female; Humans; Male; Middle Aged; N-Methylaspartate; Psychiatric Status Rating Scales	1992
[Genetic and environmental effects on neuromodulation and the antinociceptive effect of dextromethorphan]. Schweizerische medizinische Wochenschrift, 1998, Feb-07, Volume: 128, Issue:6 Topics: Adult; Analgesics, Opioid; Antitussive Agents; Dextromethorphan; Double-Blind Method; Female; Humans; Male; Metabolic Clearance Rate; N-Methylaspartate; Pain Threshold; Phenotype; Receptors, N-Methyl-D-Aspartate; Retrospective Studies; Social Environment	1998
A trial of dextromethorphan in parkinsonian patients with motor response complications. Movement disorders : official journal of the Movement Disorder Society, 1998, Volume: 13, Issue:3 Topics: Activities of Daily Living; Aged; Antiparkinson Agents; Carbidopa; Cross-Over Studies; Dextromethorphan; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Humans; Male; Middle Aged; Motor Skills; N-Methylaspartate; Neurologic Examination; Parkinson Disease	1998
Perioperative dextromethorphan reduces postoperative pain after hysterectomy. Anesthesia and analgesia, 1999, Volume: 89, Issue:2 Topics: Administration, Oral; Adult; Analgesics; Dextromethorphan; Double-Blind Method; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Female; Humans; Hysterectomy; Middle Aged; N-Methylaspartate; Pain Measurement; Pain, Postoperative	1999
Influence of CYP2D6 activity on pre-emptive analgesia by the N-methyl-D-aspartate antagonist dextromethorphan in a randomized controlled trial of acute pain. Pain physician, 2013, Volume: 16, Issue:1 Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Cytochrome P-450 CYP2D6; Dextromethorphan; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Genotype; Humans; Male; Middle Aged; N-Methylaspartate; Pain Measurement; Pain, Postoperative; Quinidine; Young Adult	2013

Other Studies

47 other study(ies) available for n-methylaspartate and dextromethorphan

Article	Year
In vivo modulation of excitatory amino acid receptors: microdialysis studies on N-methyl-D-aspartate-evoked striatal dopamine release and effects of antagonists. Brain research, 1992, Mar-06, Volume: 574, Issue:1-2 Topics: 2-Amino-5-phosphonovalerate; Animals; Cadmium; Chromatography, High Pressure Liquid; Corpus Striatum; Dextromethorphan; Dialysis; Dopamine; Dose-Response Relationship, Drug; Male; N-Methylaspartate; Potassium; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate	1992
MK-801 protects retinal neurons from hypoxia and the toxicity of glutamate and aspartate. Investigative ophthalmology & visual science, 1992, Volume: 33, Issue:12 Topics: Animals; Culture Techniques; Dextromethorphan; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hypoxia; Kynurenic Acid; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Retina	1992
Excitatory amino acids and the actions of cocaine. Brain research, 1992, Jun-05, Volume: 582, Issue:1 Topics: Animals; Caffeine; Cocaine; Dextromethorphan; Dizocilpine Maleate; Haloperidol; Male; Mice; Mice, Inbred Strains; Motor Activity; N-Methylaspartate; Pipecolic Acids; Quinoxalines; Rats; Rats, Inbred Strains; Seizures; Stereoisomerism; Stereotyped Behavior	1992
Dextromethorphan and phencyclidine receptor ligands: differential effects on K(+)- and NMDA-evoked increases in cytosolic free Ca2+ concentration. Neuroscience letters, 1991, Apr-01, Volume: 124, Issue:2 Topics: Animals; Calcium; Cyclopentanes; Cytosol; Dextromethorphan; Female; Fura-2; Hippocampus; Ketamine; Ligands; N-Methylaspartate; Parasympatholytics; Potassium; Pregnancy; Pyramidal Tracts; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine	1991
Non-competitive NMDA-receptor antagonists and anoxic degeneration of the ERG B-wave in vitro. Eye (London, England), 1991, Volume: 5 ( Pt 4) Topics: Animals; Dextromethorphan; Dizocilpine Maleate; Electroretinography; Female; In Vitro Techniques; Ketamine; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Retina; Synaptic Transmission; Time Factors	1991
Glutamate neurotoxicity in spinal cord cell culture. Neuroscience, 1991, Volume: 43, Issue:2-3 Topics: Animals; Cells, Cultured; Dextromethorphan; Dextrorphan; Glutamates; Glutamic Acid; Glycine; N-Methylaspartate; Neurons; Spinal Cord	1991
Effects of NMDA and calcium channel antagonists on regional cerebral blood flow. Neuroscience letters, 1991, Sep-30, Volume: 131, Issue:1 Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cerebral Cortex; Cerebrovascular Circulation; Dextromethorphan; Dextrorphan; Dizocilpine Maleate; Heart Rate; Ketamine; Mesencephalon; N-Methylaspartate; Nimodipine; Rabbits; Reference Values; Regional Blood Flow; Rhombencephalon	1991
Effects of non-opioid antitussives on epileptiform activity and NMDA responses in hippocampal and olfactory cortex slices. Brain research, 1990, Oct-08, Volume: 529, Issue:1-2 Topics: Animals; Antitussive Agents; Cyclopentanes; Dextromethorphan; Electric Stimulation; Epilepsy; Evoked Potentials; Guinea Pigs; Hippocampus; In Vitro Techniques; Magnesium; N-Methylaspartate; Olfactory Bulb	1990
Neocortical epileptogenesis in vitro: studies with N-methyl-D-aspartate, phencyclidine, sigma and dextromethorphan receptor ligands. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:1 Topics: Animals; Aspartic Acid; Carbachol; Cerebral Cortex; Dextromethorphan; Dose-Response Relationship, Drug; Epilepsy; In Vitro Techniques; Levorphanol; N-Methylaspartate; Potassium Channels; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma	1989
N-methyl-D-aspartate promotes the survival of cerebellar granule cells: pharmacological characterization. Neuroscience letters, 1989, Jul-03, Volume: 101, Issue:3 Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebellum; Dextromethorphan; Dibenzocycloheptenes; Dizocilpine Maleate; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter	1989
Protective effect of N-methyl-D-aspartate antagonists after focal cerebral ischemia in rabbits. Stroke, 1989, Volume: 20, Issue:9 Topics: Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dextromethorphan; Dextrorphan; Ischemic Attack, Transient; Levorphanol; Magnetic Resonance Imaging; Male; Morphinans; N-Methylaspartate; Neurons; Rabbits	1989
Dextrorphan and dextromethorphan, common antitussives, are antiepileptic and antagonize N-methyl-D-aspartate in brain slices. Neuroscience letters, 1988, Feb-29, Volume: 85, Issue:2 Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Antitussive Agents; Aspartic Acid; Cerebral Cortex; Dextromethorphan; Dextrorphan; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Levorphanol; Morphinans; N-Methylaspartate; Seizures; Valine	1988
Dextromethorphan inhibits NMDA-induced convulsions. European journal of pharmacology, 1988, Jun-22, Volume: 151, Issue:1 Topics: Animals; Anticonvulsants; Aspartic Acid; Dextromethorphan; Dibenzocycloheptenes; Dizocilpine Maleate; Levorphanol; Male; Mice; N-Methylaspartate; Psychomotor Performance; Seizures	1988
Delayed treatment with dextromethorphan and dextrorphan reduces cerebral damage after transient focal ischemia. Neuroscience letters, 1988, Jun-29, Volume: 89, Issue:2 Topics: Animals; Aspartic Acid; Brain Ischemia; Dextromethorphan; Dextrorphan; Levorphanol; Male; Morphinans; N-Methylaspartate; Rabbits	1988
The effect of experimental ischaemia and excitatory amino acid agonists on the GABA and serotonin immunoreactivities in the rabbit retina. Neuroscience, 1994, Volume: 59, Issue:4 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cycloleucine; Dextromethorphan; Eye Proteins; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamic Acid; Intraocular Pressure; Ischemia; Kainic Acid; Kynurenic Acid; Memantine; N-Methylaspartate; Oxygen; Potassium Cyanide; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Vessels; Serotonin	1994
Dextromethorphan blocks N-methyl-D-aspartate-induced currents and voltage-operated inward currents in cultured cortical neurons. European journal of pharmacology, 1993, Jul-20, Volume: 238, Issue:2-3 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amlodipine; Animals; Barium; Calcium Channels; Cells, Cultured; Cerebral Cortex; Dextromethorphan; Electrophysiology; Female; Kainic Acid; N-Methylaspartate; Neurons; PC12 Cells; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Channels	1993
Neuroprotection by N-methyl-D-aspartate antagonists in focal cerebral ischemia is dependent on continued maintenance dosing. Neuroscience, 1995, Volume: 64, Issue:1 Topics: Animals; Body Temperature; Brain Edema; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Dextromethorphan; Dextrorphan; Hydrogen-Ion Concentration; N-Methylaspartate; Neuroprotective Agents; Oxygen; Rabbits	1995
NMDA receptor subtype selectivity: eliprodil, polyamine spider toxins, dextromethorphan, and desipramine selectively block NMDA-evoked striatal acetylcholine but not spermidine release. Journal of neurochemistry, 1995, Volume: 64, Issue:5 Topics: Acetylcholine; Animals; Corpus Striatum; Desipramine; Dextromethorphan; Indoleacetic Acids; N-Methylaspartate; Phenols; Phenylacetates; Piperidines; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spider Venoms	1995
Novel anticonvulsant analogs of dextromethorphan: improved efficacy, potency, duration and side-effect profile. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:2 Topics: Animals; Anticonvulsants; Behavior, Animal; Dextromethorphan; Dose-Response Relationship, Drug; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Time Factors	1994
N-methyl-D-aspartate (NMDA) antagonist and Parkinson's disease: a pilot study with dextromethorphan. Movement disorders : official journal of the Movement Disorder Society, 1994, Volume: 9, Issue:2 Topics: Aged; Dextromethorphan; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; N-Methylaspartate; Neurologic Examination; Parkinson Disease; Receptors, N-Methyl-D-Aspartate	1994
N-methyl-D-aspartate (NMDA)-mediated muscle relaxant action of dextromethorphan in rats. Neuroreport, 1993, Volume: 4, Issue:7 Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Dextromethorphan; Electric Stimulation; Electromyography; H-Reflex; Injections, Intraperitoneal; Injections, Spinal; Male; Muscle Relaxation; Muscles; N-Methylaspartate; Quinoxalines; Rats; Rats, Wistar; Reflex, Stretch	1993
Dextromethorphan in molybdenum cofactor deficiency. European journal of pediatrics, 1996, Volume: 155, Issue:5 Topics: Anticonvulsants; Child, Preschool; Coenzymes; Dextromethorphan; Epilepsy; Humans; Male; Metabolism, Inborn Errors; Metalloproteins; Molybdenum Cofactors; N-Methylaspartate; Pteridines	1996
Dextromethorphan reduces functional deficits and neuronal damage after global ischemia in rats. Brain research, 1996, Nov-25, Volume: 741, Issue:1-2 Topics: Animals; Behavior, Animal; Brain Ischemia; Dextromethorphan; Male; Maze Learning; Memory; Motor Activity; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Wistar	1996
N-methyl-D-aspartate-mediated glutamate toxicity in the developing rabbit retina. Journal of neuroscience research, 1997, Feb-15, Volume: 47, Issue:4 Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Cell Death; Cyclic GMP; Dextromethorphan; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rabbits; Receptors, N-Methyl-D-Aspartate; Retina	1997
Dextromethorphan in nonketotic hyperglycinaemia: metabolic variation confounds the dose-response relationship. Journal of inherited metabolic disease, 1997, Volume: 20, Issue:1 Topics: Child; Dextromethorphan; Dextrorphan; Dose-Response Relationship, Drug; Female; Humans; Hyperglycemic Hyperosmolar Nonketotic Coma; Infant, Newborn; N-Methylaspartate; Seizures	1997
Dextromethorphan and other N-methyl-D-aspartate receptor antagonists are teratogenic in the avian embryo model. Pediatric research, 1998, Volume: 43, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Dextromethorphan; Embryo, Nonmammalian; N-Methylaspartate; Quinolinic Acids; Receptors, Amino Acid; Teratogens	1998
The teratogenicity of N-methyl-D-aspartate (NMDA) receptor antagonists. Pediatric research, 1998, Volume: 44, Issue:3 Topics: Animals; Antitussive Agents; Chick Embryo; Dextromethorphan; Female; Humans; N-Methylaspartate; Pregnancy; Rabbits; Receptors, N-Methyl-D-Aspartate; Teratogens	1998
The teratogenicity of N-methyl-D-aspartate (NMDA) receptor antagonists. Pediatric research, 1998, Volume: 44, Issue:3 Topics: Animals; Antitussive Agents; Chick Embryo; Dextromethorphan; Female; Humans; Maternal-Fetal Exchange; N-Methylaspartate; Pregnancy; Receptors, N-Methyl-D-Aspartate; Teratogens	1998
Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice. General pharmacology, 1999, Volume: 32, Issue:3 Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Clonidine; Dextromethorphan; Drug Interactions; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Ketamine; Mice; Muscimol; N-Methylaspartate; Picrotoxin; Receptors, GABA; Receptors, Glutamate; Seizures; Theophylline	1999
Nitric oxide synthase inhibitors enhance 5-HT2 receptor-mediated behavior, the head-twitch response in mice. Life sciences, 1999, Volume: 64, Issue:26 Topics: Animals; Arginine; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Head Movements; Male; Methylene Blue; Mice; Mice, Inbred ICR; Molsidomine; N-Methylaspartate; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Penicillamine; Receptors, Serotonin; Serotonin; Serotonin Antagonists	1999
Mechanisms of use-dependent plasticity in the human motor cortex. Proceedings of the National Academy of Sciences of the United States of America, 2000, Mar-28, Volume: 97, Issue:7 Topics: Dextromethorphan; Evoked Potentials; Humans; Lamotrigine; Long-Term Potentiation; Lorazepam; Motor Cortex; N-Methylaspartate; Triazines	2000
Co-administration of dextromethorphan during pregnancy and throughout lactation significantly decreases the adverse effects associated with chronic morphine administration in rat offspring. Life sciences, 2001, Oct-05, Volume: 69, Issue:20 Topics: Analgesics, Opioid; Animals; Antitussive Agents; Body Weight; Dextromethorphan; Drug Combinations; Drug Tolerance; Female; Hippocampus; Injections, Subcutaneous; Lactation; Longevity; Male; Morphine; Morphine Dependence; N-Methylaspartate; Pain Measurement; Pain Threshold; Pregnancy; Pregnancy, Animal; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley	2001
Glutamate-induced excitotoxicity in retina: neuroprotection with receptor antagonist, dextromethorphan, but not with calcium channel blockers. Neurochemical research, 2002, Volume: 27, Issue:1-2 Topics: Animals; Calcium Channel Blockers; Cell Death; Dextromethorphan; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Laser Coagulation; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Rabbits; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Verapamil	2002
N-methyl-D-aspartate antagonists and WIN 55212-2 [4,5-dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1-i,j]quinolin-6-one], a cannabinoid agonist, interact to produce synergistic hypothermia. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:1 Topics: Animals; Benzoxazines; Body Temperature; Calcium Channel Blockers; Cannabinoids; Dextromethorphan; Drug Synergism; Excitatory Amino Acid Antagonists; Hypothermia; Isoquinolines; Kinetics; Morpholines; N-Methylaspartate; Naphthalenes; Rats; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship	2002
Interactions of NMDA antagonists and an alpha 2 agonist with mu, delta and kappa opioids in an acute nociception assay. Acta anaesthesiologica Belgica, 2002, Volume: 53, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzamides; Clonidine; Dextromethorphan; Dose-Response Relationship, Drug; Drug Synergism; Fentanyl; Ketamine; Male; Mice; Morphine; N-Methylaspartate; Pain; Pain Measurement; Piperazines; Reaction Time; Receptors, Opioid	2002
Characterization of the non-competitive antagonist binding site of the NMDA receptor in dark Agouti rats. Life sciences, 2004, Aug-06, Volume: 75, Issue:12 Topics: Animals; Binding, Competitive; Brain; Dextromethorphan; Dioxolanes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Ketamine; N-Methylaspartate; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Mutant Strains; Receptors, N-Methyl-D-Aspartate; Scintillation Counting; Tritium	2004
Commentary on: Severe manifestations of coricidin intoxication. The American journal of emergency medicine, 2004, Volume: 22, Issue:7 Topics: Acetaminophen; Chlorpheniramine; Dextromethorphan; Drug Combinations; Drug Overdose; Excitatory Amino Acid Antagonists; Humans; N-Methylaspartate; Nonprescription Drugs; Phenylpropanolamine; Receptors, N-Methyl-D-Aspartate; Substance-Related Disorders	2004
Effects of the competitive N-methyl-D-aspartate receptor antagonist, LY235959 [(-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid], on responding for cocaine under both fixed and progressive ratio schedules of reinforcement. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:1 Topics: Animals; Cocaine; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Isoquinolines; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Self Administration	2005
Comparison of NMDA modulation of breathing and NR1 expression in medullary nuclei of weanling male and female rats. Respiratory physiology & neurobiology, 2007, Mar-15, Volume: 155, Issue:3 Topics: Animals; Carbon Dioxide; Cell Count; Dextromethorphan; Excitatory Amino Acid Agonists; Female; Hypoglossal Nerve; Immunohistochemistry; Male; Medulla Oblongata; N-Methylaspartate; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Respiratory Mechanics; Respiratory Muscles; Sex Characteristics; Solitary Nucleus; Tongue; Weaning	2007
Sex differences in NMDA antagonist enhancement of morphine antihyperalgesia in a capsaicin model of persistent pain: comparisons to two models of acute pain. Pharmacology, biochemistry, and behavior, 2008, Volume: 89, Issue:2 Topics: Acute Disease; Analgesics, Opioid; Animals; Capsaicin; Data Interpretation, Statistical; Dextromethorphan; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Hot Temperature; Hyperalgesia; Male; Morphine; N-Methylaspartate; Pain Measurement; Rats; Rats, Inbred F344; Sex Characteristics	2008
Sigma ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias. Neuroreport, 2008, Jan-08, Volume: 19, Issue:1 Topics: Adrenergic Agents; Amphetamine; Animals; Anti-Anxiety Agents; Behavior, Animal; Dextromethorphan; Disease Models, Animal; Dopamine Agents; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Levodopa; Ligands; Male; N-Methylaspartate; Neurotoxicity Syndromes; Oxidopamine; Pyrimidines; Rats; Rats, Sprague-Dawley; Time Factors	2008
N-methyl-D-aspartate (NMDA) antagonists--S(+)-ketamine, dextrorphan, and dextromethorphan--act as calcium antagonists on bovine cerebral arteries. Journal of neurosurgical anesthesiology, 2008, Volume: 20, Issue:4 Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Cattle; Dextromethorphan; Dextrorphan; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; In Vitro Techniques; Isometric Contraction; Ketamine; Middle Cerebral Artery; Muscle Tonus; Muscle, Smooth, Vascular; N-Methylaspartate; Nimodipine; Vascular Resistance; Vasoconstrictor Agents	2008
Antitussive effects of memantine in guinea pigs. Chest, 2012, Volume: 141, Issue:4 Topics: Animals; Antitussive Agents; Baclofen; Bradykinin; Citric Acid; Cough; Dextromethorphan; Guinea Pigs; Ketamine; Male; Mecamylamine; Memantine; N-Methylaspartate; Serotonin	2012
Evaluation of brain SERT with 4-[ Toxicology and applied pharmacology, 2019, 09-01, Volume: 378 Topics: Animals; Benzylamines; Brain; Brain Stem; Dextromethorphan; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Hearing Loss; Male; N-Methylaspartate; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Serotonergic Neurons; Serotonin Plasma Membrane Transport Proteins	2019
N-Substituted-3-alkoxy-derivatives of dextromethorphan are functional NMDA receptor antagonists in vivo: Evidence from an NMDA-induced seizure model in rats. Pharmacology, biochemistry, and behavior, 2021, Volume: 203 Topics: Alcohols; Animals; Anticonvulsants; Binding Sites; Dextromethorphan; Dextrorphan; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Infusions, Intraventricular; Ligands; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Seizures; Sigma-1 Receptor; Treatment Outcome	2021
Chronic Light-Distorted Glutamate-Cortisol Signaling, Behavioral and Histological Markers, and Induced Oxidative Stress and Dementia: An Amelioration by Melatonin. ACS chemical neuroscience, 2022, 06-01, Volume: 13, Issue:11 Topics: Animals; Biomarkers; Circadian Rhythm; Dementia; Dextromethorphan; Glutamic Acid; Hydrocortisone; Light; Melatonin; Mifepristone; N-Methylaspartate; Oxidative Stress; Rats; Rats, Wistar	2022
Understanding the Efficacy and Mechanism of Action of a Dextromethorphan-Bupropion Combination: Where Does It Fit in the NMDA Versus mu-Opioid Story? The American journal of psychiatry, 2022, Volume: 179, Issue:7 Topics: Analgesics, Opioid; Bupropion; Dextromethorphan; Excitatory Amino Acid Antagonists; Humans; N-Methylaspartate	2022