Page last updated: 2024-08-22

n-methylaspartate and clozapine

n-methylaspartate has been researched along with clozapine in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.70)18.7374
1990's7 (25.93)18.2507
2000's13 (48.15)29.6817
2010's5 (18.52)24.3611
2020's1 (3.70)2.80

Authors

AuthorsStudies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Johnson, KM; Snell, LD1
Duhan, NL; Farber, NB; Foster, J; Olney, JW1
Kulkarni, SK; Ninan, I1
Hayashi, T; Kagaya, A; Nishida, A; Shimizu, M; Su, TP; Yamawaki, S1
Breier, A1
Arvanov, VL; Wang, RY1
Feuerstein, TJ; Fischer, W; Kiefer, G1
Feldon, J; Jongen-Rêlo, AL; Pouzet, B; Weiner, I; Zhang, W1
Arvanov, V; Jardemark, KE; Liang, X; Wang, RY1
Bast, T; Feldon, J; Heidbreder, C; Zhang, WN1
Jardemark, KE; Liang, X; Ninan, I; Wang, RY2
Jardemark, KE; Ninan, I; Wang, RY1
Ninan, I; Wang, RY1
Bardgett, ME; Foltz, RF; Griffith, MS; Hopkins, JA; Massie, CM; O'Connell, SM1
Bennett, S; Gronier, B1
Duncan, GE; Farrington, JS; Inada, K; Koller, BH; Moy, SS1
Heinz, A; Hinzpeter, A; Krebs, M; Leopold, K; Schaefer, M1
Jardemark, KE; Konradsson, A; Marcus, MM; Schilström, B; Svensson, TH1
Alexander, KS; Brooks, JM; Bruno, JP; Sarter, M1
Arnt, J; Porter, JH; Vunck, SA; Wiebelhaus, JM1
Adrover, MF; Alvarez, VA; Bock, R; Christensen, CH; Dobi, A; Gremel, CM; Kaplan, AR; Kramer, PF; Markey, E; Shin, JH1
Bogus, K; Filipczyk, Ł; Krzystanek, M; Pałasz, A; Rojczyk, E; Wiaderkiewicz, A; Wiaderkiewicz, R; Worthington, J1
Belardo, C; Bertolino, A; Bolognesi, P; Errico, F; Frassineti, M; Iannotta, M; Maione, S; Morari, M; Motta, Z; Novellis, V; Nuzzo, T; Paolone, G; Pollegioni, L; Rosini, E; Sacchi, S; Squillace, M; Usiello, A1
Adamsky, A; Doron, A; Goshen, I; Groysman, M; Horn, H; Kol, A; Kreisel, T; London, M; Melcer, T; Ozeri-Engelhard, N; Refaeli, R; Regev, L1
Eo, J; Kang, J; Park, HJ; Youn, T1

Reviews

1 review(s) available for n-methylaspartate and clozapine

ArticleYear
Cognitive deficit in schizophrenia and its neurochemical basis.
    The British journal of psychiatry. Supplement, 1999, Issue:37

    Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Cognition Disorders; Glutamic Acid; Haloperidol; Humans; N-Methylaspartate; Olanzapine; Pirenzepine; Risperidone; Schizophrenia; Schizophrenic Psychology

1999

Other Studies

26 other study(ies) available for n-methylaspartate and clozapine

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Antagonism of N-methyl-D-aspartate-induced transmitter release in the rat striatum by phencyclidine-like drugs and its relationship to turning behavior.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:1

    Topics: Acetylcholine; Amphetamine; Animals; Apomorphine; Aspartic Acid; Benzomorphans; Chlorpromazine; Clozapine; Corpus Striatum; Cyclazocine; Dioxolanes; Dopamine; Haloperidol; Ketamine; Male; Mathematics; Motor Activity; N-Methylaspartate; Phencyclidine; Posture; Rats; Rats, Inbred Strains; Substantia Nigra

1985
Olanzapine and fluperlapine mimic clozapine in preventing MK-801 neurotoxicity.
    Schizophrenia research, 1996, Volume: 21, Issue:1

    Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Dibenzazepines; Dibenzoxazepines; Dizocilpine Maleate; Female; N-Methylaspartate; Nervous System; Olanzapine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

1996
Preferential blockade by clozapine of hyperlocomotion induced by non-competitive NMDA antagonist MK-801.
    Indian journal of physiology and pharmacology, 1998, Volume: 42, Issue:3

    Topics: Analysis of Variance; Animals; Antipsychotic Agents; Benzazepines; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Hyperkinesis; Mice; Mice, Inbred BALB C; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Wistar; Stereotyped Behavior; Sulpiride

1998
Neuroleptics with differential affinities at dopamine D2 receptors and sigma receptors affect differently the N-methyl-D-aspartate-induced increase in intracellular calcium concentration: involvement of protein kinase.
    Synapse (New York, N.Y.), 1999, Volume: 31, Issue:1

    Topics: Animals; Antipsychotic Agents; Calcium; Cells, Cultured; Chlorpromazine; Clozapine; Dopamine Antagonists; Frontal Lobe; Guanidines; Haloperidol; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, sigma; Sulpiride

1999
Clozapine, but not haloperidol, prevents the functional hyperactivity of N-methyl-D-aspartate receptors in rat cortical neurons induced by subchronic administration of phencyclidine.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipsychotic Agents; Clozapine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Haloperidol; Male; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission

1999
Effects of amitriptyline, amitriptylinoxide, doxepine and clozapine on N-methyl-D-aspartate-evoked release of [3H]-acetylcholine in rat caudatoputamen.
    Arzneimittel-Forschung, 1999, Volume: 49, Issue:10

    Topics: Acetylcholine; Algorithms; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Caudate Nucleus; Chronic Disease; Clozapine; Doxepin; Excitatory Amino Acid Agonists; Male; N-Methylaspartate; Pain; Putamen; Rats; Rats, Wistar

1999
Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: a possible model for the screening of atypical antipsychotics.
    Neuroreport, 1999, Aug-20, Volume: 10, Issue:12

    Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Excitatory Amino Acid Antagonists; Haloperidol; Hippocampus; Infusions, Parenteral; Male; N-Methylaspartate; Rats; Rats, Wistar; Reflex, Startle

1999
Subchronic treatment with either clozapine, olanzapine or haloperidol produces a hyposensitive response of the rat cortical cells to N-methyl-D-aspartate.
    Neuroscience, 2000, Volume: 100, Issue:1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Haloperidol; In Vitro Techniques; Male; N-Methylaspartate; Olanzapine; Pharmaceutical Vehicles; Pirenzepine; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Time Factors

2000
Hyperactivity and disruption of prepulse inhibition induced by N-methyl-D-aspartate stimulation of the ventral hippocampus and the effects of pretreatment with haloperidol and clozapine.
    Neuroscience, 2001, Volume: 103, Issue:2

    Topics: Animals; Clozapine; Dopamine Antagonists; Excitatory Amino Acid Agonists; Haloperidol; Hippocampus; Hyperkinesis; Male; Motor Activity; N-Methylaspartate; Neural Inhibition; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia; Serotonin Antagonists

2001
Calcium/calmodulin-dependent kinase II is involved in the facilitating effect of clozapine on NMDA- and electrically evoked responses in the medial prefrontal cortical pyramidal cells.
    Synapse (New York, N.Y.), 2003, Mar-15, Volume: 47, Issue:4

    Topics: Animals; Antipsychotic Agents; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Clozapine; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Mice; Mutation; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Rats; Sulfonamides

2003
Olanzapine and clozapine but not haloperidol reverse subchronic phencyclidine-induced functional hyperactivity of N-methyl-D-aspartate receptors in pyramidal cells of the rat medial prefrontal cortex.
    Neuropharmacology, 2003, Volume: 44, Issue:4

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Haloperidol; Male; Membrane Potentials; N-Methylaspartate; Olanzapine; Patch-Clamp Techniques; Phencyclidine; Pirenzepine; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia

2003
Modulation of the ability of clozapine to facilitate NMDA- and electrically evoked responses in pyramidal cells of the rat medial prefrontal cortex by dopamine: pharmacological evidence.
    The European journal of neuroscience, 2003, Volume: 17, Issue:6

    Topics: 5-Hydroxytryptophan; alpha-Methyltyrosine; Animals; Antipsychotic Agents; Benzazepines; Clozapine; Dopamine; Dopamine Agents; Dopamine Antagonists; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Levodopa; Male; N-Methylaspartate; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reserpine; Synaptic Transmission; Tyrosine 3-Monooxygenase

2003
Protein kinase C is involved in clozapine's facilitation of N-methyl-D-aspartate- and electrically evoked responses in pyramidal cells of the medial prefrontal cortex.
    Neuroscience, 2003, Volume: 118, Issue:2

    Topics: Alkaloids; Animals; Benzophenanthridines; Clozapine; Drug Interactions; Electric Stimulation; Electrophysiology; Enzyme Activators; Enzyme Inhibitors; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Fluorobenzenes; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Mice; Mice, Knockout; Mice, Mutant Strains; N-Methylaspartate; Peptide Fragments; Phenanthridines; Phorbols; Piperidines; Protein Kinase C; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Tetradecanoylphorbol Acetate; Time Factors

2003
The effects of clozapine on delayed spatial alternation deficits in rats with hippocampal damage.
    Neurobiology of learning and memory, 2006, Volume: 85, Issue:1

    Topics: Analysis of Variance; Animals; Antipsychotic Agents; Brain Injuries; Clozapine; Hippocampus; Male; Maze Learning; Memory; Microinjections; N-Methylaspartate; Neurotoxins; Rats; Rats, Sprague-Dawley; Space Perception; Spatial Behavior; Statistics, Nonparametric; Time Factors

2006
Modulation of striatal dopamine release in vitro by agonists of the glycineB site of NMDA receptors; interaction with antipsychotics.
    European journal of pharmacology, 2005, Dec-19, Volume: 527, Issue:1-3

    Topics: Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Haloperidol; Magnesium; Male; N-Methylaspartate; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Salicylamides

2005
Assessment of NMDA receptor activation in vivo by Fos induction after challenge with the direct NMDA agonist (tetrazol-5-yl)glycine: effects of clozapine and haloperidol.
    Journal of neural transmission (Vienna, Austria : 1996), 2007, Volume: 114, Issue:7

    Topics: Animals; Clozapine; Glycine; Haloperidol; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mice, Transgenic; N-Methylaspartate; Proto-Oncogene Proteins c-fos; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tetrazoles

2007
Memantine-associated reversal of clozapine-induced weight gain.
    Pharmacopsychiatry, 2007, Volume: 40, Issue:4

    Topics: Adult; Antipsychotic Agents; Clozapine; Dopamine Agents; Humans; Male; Memantine; N-Methylaspartate; Obesity; Schizophrenia

2007
Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine.
    Synapse (New York, N.Y.), 2009, Volume: 63, Issue:10

    Topics: Animals; Biophysical Phenomena; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; Fructose; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Neuroprotective Agents; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Raclopride; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Synaptic Transmission; Topiramate

2009
Disruption of mesolimbic regulation of prefrontal cholinergic transmission in an animal model of schizophrenia and normalization by chronic clozapine treatment.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:13

    Topics: Acetylcholine; Aging; Amphetamine; Animals; Animals, Newborn; Clozapine; Disease Models, Animal; Hippocampus; Ibotenic Acid; Male; Microinjections; N-Methylaspartate; Neural Pathways; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Schizophrenia; Time Factors

2009
Clozapine and N-methyl-D-aspartate have positive modulatory actions on their respective discriminative stimulus properties in C57BL/6 mice.
    European journal of pharmacology, 2011, Jan-15, Volume: 650, Issue:2-3

    Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Antipsychotic Agents; Clozapine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Generalization, Stimulus; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Prazosin

2011
Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use.
    Nature neuroscience, 2013, Volume: 16, Issue:5

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bacterial Proteins; Channelrhodopsins; Clozapine; Cocaine; Compulsive Behavior; Dopamine Uptake Inhibitors; Excitatory Postsynaptic Potentials; Green Fluorescent Proteins; Luminescent Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Nerve Net; Neural Pathways; Neurons; Nucleus Accumbens; Receptors, Dopamine D2; Reward; Self Administration; Synapses; Time Factors

2013
Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalon.
    Pharmacological reports : PR, 2016, Volume: 68, Issue:5

    Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Diencephalon; Down-Regulation; Haloperidol; Hippocampus; Hypothalamus; Male; N-Methylaspartate; Neocortex; Olanzapine; Protein Subunits; Rats; Rats, Sprague-Dawley; Up-Regulation

2016
Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity.
    Scientific reports, 2017, 04-10, Volume: 7

    Topics: Animals; Benzodiazepines; Clozapine; D-Aspartate Oxidase; Dose-Response Relationship, Drug; Enzyme Activation; Glutamic Acid; Humans; Male; Mice; Mice, Knockout; N-Methylaspartate; Olanzapine; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors

2017
Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement.
    Cell, 2018, 06-28, Volume: 174, Issue:1

    Topics: Animals; Astrocytes; Calcium; Clozapine; GTP-Binding Protein alpha Subunits, Gq-G11; Hippocampus; Long-Term Potentiation; Male; Memory; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Optogenetics; Patch-Clamp Techniques; Proto-Oncogene Proteins c-fos; Stress, Psychological; Synaptic Potentials

2018
Neuropharmacological computational analysis of longitudinal electroencephalograms in clozapine-treated patients with schizophrenia using hierarchical dynamic causal modeling.
    NeuroImage, 2023, 07-15, Volume: 275

    Topics: Brain; Brain Mapping; Clozapine; Electroencephalography; Hallucinations; Humans; Magnetic Resonance Imaging; N-Methylaspartate; Nerve Net; Neuropharmacology; Schizophrenia

2023