Page last updated: 2024-08-22

n-methylaspartate and calpain

n-methylaspartate has been researched along with calpain in 72 studies

Research

Studies (72)

TimeframeStudies, this research(%)All Research%
pre-19902 (2.78)18.7374
1990's13 (18.06)18.2507
2000's35 (48.61)29.6817
2010's19 (26.39)24.3611
2020's3 (4.17)2.80

Authors

AuthorsStudies
Ceccarini, M; Di Stasi, AM; Gallo, V; Petrucci, TC1
Kegerise, C; Noszek, JC; Siman, R1
Noszek, JC; Siman, R1
Bahr, BA; Lynch, G; Park, GY; Tiriveedhi, S1
Brorson, JR; Marcuccilli, CJ; Miller, RJ1
Hajimohammadreza, I; Posner, A; Raser, KJ; Wang, KK; Yuen, PW1
Arai, A; Bahr, BA; del Cerro, S; Kessler, M; Lynch, G; Rivera, S; Vanderklish, P1
Roberts-Lewis, JM; Siman, R1
Breeze, LJ; Catterall, WA; Chavkin, C; Hell, JW; Wang, KK; Westenbroek, RE1
Catani, MV; Corasaniti, MT; Finazzi-Agrò, A; Melino, G; Navarra, M; Nisticò, G1
Bahr, BA; Bednarski, E; Gall, C; Lynch, G; Saido, TC; Vanderklish, P1
Faddis, BT; Goldberg, MP; Hasbani, MJ1
Galindo, MF; Jordán, J; Miller, RJ1
Baudry, M; Bi, X; Gellerman, DM1
Hajimohammadreza, I; Nadimpalli, R; Nath, R; Raser, KJ; Scott, M; Wang, KK1
Crossin, KL; Edelman, GM; Gally, JA; Holst, BH; Krushel, LA; Vanderklish, PW1
Bahr, BA1
Baudry, M; Lu, X; Rong, Y1
Cole, GM; Krohn, AJ; Lankiewicz, S; Marc Luetjens, C; Poppe, M; Prehn, JH; Saido, TC; Truc Bui, N1
Atkinson, T; Chakravarthy, B; Durkin, JP; Hewitt, K; Morley, P; Tauskela, J; Tremblay, R1
Baudry, M; Broutman, G1
Baudry, M; Lu, X; Sheng, M; Wyszynski, M1
Comas, T; Hewitt, K; Hogan, M; Monette, R; Morley, P; Paris, J; Tauskela, JS1
Beaman-Hall, CM; Mathur, A; Tremper-Wells, B; Vallano, ML1
Kerokoski, P; Pirttilä, T; Salminen, A; Soininen, H; Suuronen, T1
Hao, HP; Hashioka, S; Miyamoto, K; Murao, K; Nakanishi, H; Saido, TC; Zhang, J1
Aarts, M; Arundine, M; Lau, A; Tymianski, M1
Lu, YF; Matsui, H; Matsushita, M; Tomizawa, K; Wu, HY; Yan, Z; Yuen, EY1
Caprioli, J; Chiu, K; Kwong Kwong, JM; Lam, TT; Ying Li, WW1
Ando, K; Kudo, Y; Takahashi, M1
Jones, Y; Larson, J; Lugli, G; Martone, ME; Smalheiser, NR1
Chakravarthy, B; Chen, Q; Kowara, R; Milliken, M1
Baudry, M; Zhou, M1
Bretin, S; Gauchy, C; Glowinski, J; Honnorat, J; Marin, P; Maus, M; Prémont, J; Rogemond, V; Torrens, Y1
Cheng Liu, M; Gold, MS; Hayes, RL; Kobeissy, FH; Larner, SF; Wang, KK; Warren, MW; Zheng, W1
Hoskison, MM; Shuttleworth, CW1
Chakravarthy, B; Kowara, R; Moraleja, KL2
Kirkeby, A; Leist, M; Montero, M; Noraberg, J; Poulsen, FR; van Beek, J; Zimmer, J1
Mansuy, IM; Phan, T; Shimizu, K; Storm, DR1
Fang, T; Hayes, RL; Kobeissy, FH; Ottens, AK; Sadasivan, S; Wang, KK; Zhang, Z1
Lipton, P; Windelborn, JA1
Ren, Y; Yan, Z; Yuen, EY1
Granic, I; Gross, G; Luiten, P; Möller, A; Nimmrich, V; Nyakas, C; Reymann, KG; Schoemaker, H; Schröder, UH; Szabo, R; Wicke, K1
Connell, BJ; Saleh, MC; Saleh, TM1
Endo, S; Kondo, M; Mourin, R; Nakazawa, T; Nishida, K; Saido, TC; Shimura, M; Yokokura, S1
Amesquita, M; Bevers, MB; Lawrence, E; Maronski, M; Neumar, RW; Starr, N1
Baik, EJ; Jang, YN; Jung, YS; Kim, CH; Lee, SH; Moon, CH1
Cao, G; Chen, J; Gao, Y; Kintner, DB; Signore, AP; Sun, D; Vosler, PS; Wang, S1
Avila, J; Goñi-Oliver, P; Hernández, F1
Hara, H; Inokuchi, Y; Matsunaga, N; Nakajima, Y; Oka, T; Shimazawa, M; Suemori, S; Yamamoto, T1
Cai, S; Cao, G; Chen, X; Fleenor, DL; Liu, X; Ma, J; Pang, IH; Wang, Y; Yan, N; Yu, W; Yuan, Y; Zeng, H1
Gross, G; Hahn, A; Möller, A; Nimmrich, V; Reymann, KG; Schöder, UH; Schoemaker, H; Strassburger, M; Wicke, K1
Bessero, AC; Bonny, C; Chiodini, F; Clarke, PG; Rungger-Brändle, E1
Fukunaga, K; Shioda, N1
Hayes, RL; Kobeissy, F; Liu, MC; Wang, KK; Zhang, Z; Zheng, W1
Bito, H; Li, W; Mao, Z; She, H; Wei, G; Yin, Y1
Bonner, H; Courtney, MJ; D'Orsi, B; Düssmann, H; Prehn, JH; Tuffy, LP; Ward, MW; Woods, I1
Hara, H; Nakanishi, T; Ohno, Y; Shimazawa, M; Tsuruma, K; Umigai, N1
Berry, JN; Butler, TR; Prendergast, MA; Sharrett-Field, LJ1
Ahmad, F; Blaesse, P; Kaila, K; Puskarjov, M1
Battaglia, G; Bruno, V; Merlo, S; Molinaro, G; Nicoletti, F; Sortino, MA; Spampinato, SF1
Colacurcio, DJ; Grigoriev, G; Jordan-Sciutto, KL; Lindl, KA; Ting, JH; Wang, Y; Zyskind, JW1
Amini, M; Baudry, M; Beique, JC; Bergeron, R; Farazifard, R; Greer, PA; Hage, F; Lagace, DC; Ma, CL; Park, DS; Savitt, JM; Slack, RS; Vanderluit, J; Zhang, Y; Zhu, G; Zoltewicz, JS1
Bouthiette, F; Cao, R; Fabian, MR; Gamache, K; Gkogkas, CG; Khoutorsky, A; Lacaille, JC; Mogil, JS; Nader, K; Parsyan, A; Prager-Khoutorsky, M; Sonenberg, N; Sorge, RE; Yanagiya, A1
Alberdi, E; Matute, C; Ruiz, A1
Chimura, T; Launey, T; Yoshida, N1
Daigaku, R; Fujita, K; Maekawa, S; Maruyama, K; Moritoh, S; Murayama, N; Nakazawa, T; Nishiguchi, KM; Omodaka, K; Sato, K; Shiga, Y; Tawarayama, H; Yabana, T1
Johnson, C; Kobeissy, F; Kurup, M; Mouhawasse, E; Nguyen, L; Pafundi, N; Torres, I; Wang, KK; Yadikar, H; Yang, Z; Yost, R1
Bao, X; Cheng, H; Cheng, Q; Feng, D; Hua, Q; Li, Y; Liu, W; Luo, Y; Luo, Z; Tang, S; Zhou, Y1
Ayuso-Dolado, S; Díaz-Guerra, M; Esteban-Ortega, GM; Vidaurre, ÓG1
Choi, EJ; Kim, E; Kim, Y; Lee, IY; Lee, R; Lim, JM1

Reviews

1 review(s) available for n-methylaspartate and calpain

ArticleYear
[Functional roles of constitutively active calcineurin in delayed neuronal death after brain ischemia].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2011, Volume: 131, Issue:1

    Topics: Active Transport, Cell Nucleus; Animals; Brain Ischemia; Calcineurin; Calcium; Calcium Channels; Calpain; Cell Death; Cell Nucleus; Disease Models, Animal; Fas Ligand Protein; Forkhead Box Protein O1; Forkhead Transcription Factors; Mice; N-Methylaspartate; Neurons; NFATC Transcription Factors; Protein Binding; Up-Regulation

2011

Other Studies

71 other study(ies) available for n-methylaspartate and calpain

ArticleYear
Neuronal fodrin proteolysis occurs independently of excitatory amino acid-induced neurotoxicity.
    Neuron, 1991, Volume: 6, Issue:3

    Topics: Animals; Blotting, Northern; Calcium; Calcium Channels; Calpain; Carrier Proteins; Cattle; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Kainic Acid; Leupeptins; Microfilament Proteins; N-Methylaspartate; Neurons; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Time Factors

1991
Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1989, Volume: 9, Issue:5

    Topics: Animals; Aspartic Acid; Calpain; Colchicine; Dose-Response Relationship, Drug; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Neurotoxins; Peptide Hydrolases; Rats; Rats, Inbred Strains; Spectrin; Time Factors; Tissue Distribution

1989
Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo.
    Neuron, 1988, Volume: 1, Issue:4

    Topics: Animals; Aspartic Acid; Brain; Calpain; Cytosol; Enzyme Activation; Erythrocytes; Humans; Isoenzymes; Kainic Acid; Male; N-Methylaspartate; Nerve Tissue Proteins; Peptide Mapping; Rats; Rats, Inbred Strains; Spectrin; Substrate Specificity

1988
Induction of calpain-mediated spectrin fragments by pathogenic treatments in long-term hippocampal slices.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 273, Issue:2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Calpain; Culture Techniques; Hippocampus; Hydrolysis; Molecular Sequence Data; N-Methylaspartate; Peptide Fragments; Rats; Receptors, AMPA; Spectrin

1995
Delayed antagonism of calpain reduces excitotoxicity in cultured neurons.
    Stroke, 1995, Volume: 26, Issue:7

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Calpain; Cell Survival; Cells, Cultured; Cerebellum; Dipeptides; Enzyme Activation; Glutamic Acid; Hippocampus; Kainic Acid; Leucine; N-Methylaspartate; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Rats; Receptors, N-Methyl-D-Aspartate; Spectrin; Time Factors

1995
Aurintricarboxylic acid is an inhibitor of mu- and m-calpain.
    Biochemistry and molecular biology international, 1995, Volume: 36, Issue:2

    Topics: Amino Acid Sequence; Animals; Apoptosis; Aurintricarboxylic Acid; Calpain; Caseins; Cathepsin B; Cells, Cultured; Cerebral Cortex; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Kinetics; L-Lactate Dehydrogenase; Molecular Sequence Data; N-Methylaspartate; Neurons; Papain; Peptides; Rats; Spectrin

1995
Stimulation of NMDA receptors activates calpain in cultured hippocampal slices.
    Neuroscience letters, 1994, Feb-14, Volume: 167, Issue:1-2

    Topics: Animals; Calcium; Calpain; Culture Techniques; Dizocilpine Maleate; Hippocampus; N-Methylaspartate; Osmolar Concentration; Rats; Receptors, N-Methyl-D-Aspartate; Spectrin; Time Factors

1994
Spectrin proteolysis in the hippocampus: a biochemical marker for neuronal injury and neuroprotection.
    Annals of the New York Academy of Sciences, 1993, May-28, Volume: 679

    Topics: Animals; Biomarkers; Calpain; Carbazoles; Cell Death; Dizocilpine Maleate; Enzyme Activation; Female; Hippocampus; Indole Alkaloids; Kainic Acid; Male; N-Methylaspartate; Neurons; Neurotoxins; Protein Kinase C; Rats; Rats, Sprague-Dawley; Spectrin

1993
N-methyl-D-aspartate receptor-induced proteolytic conversion of postsynaptic class C L-type calcium channels in hippocampal neurons.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Apr-16, Volume: 93, Issue:8

    Topics: Animals; Calcium; Calcium Channels; Calpain; Endopeptidases; Hippocampus; Immunohistochemistry; In Vitro Techniques; Microscopy, Immunoelectron; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission

1996
NMDA and HIV-1 coat protein, GP120, produce necrotic but not apoptotic cell death in human CHP100 neuroblastoma cultures via a mechanism involving calpain.
    Biochemical and biophysical research communications, 1996, Dec-04, Volume: 229, Issue:1

    Topics: Calcium; Calpain; Cell Death; Cell Nucleus; Cysteine Proteinase Inhibitors; Enzyme Activation; HIV Envelope Protein gp120; Humans; N-Methylaspartate; Necrosis; Neuroblastoma; Neurons; Neurotoxins; Receptors, N-Methyl-D-Aspartate; Tumor Cells, Cultured

1996
Translational suppression of calpain I reduces NMDA-induced spectrin proteolysis and pathophysiology in cultured hippocampal slices.
    Brain research, 1995, Oct-02, Volume: 694, Issue:1-2

    Topics: Animals; Antisense Elements (Genetics); Base Sequence; Blotting, Western; Calpain; Culture Techniques; Electrophysiology; Hippocampus; Immunohistochemistry; Molecular Sequence Data; N-Methylaspartate; Oligonucleotide Probes; Peptide Hydrolases; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Spectrin

1995
Calpain activation contributes to dendritic remodeling after brief excitotoxic injury in vitro.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Feb-01, Volume: 17, Issue:3

    Topics: Animals; Calpain; Cells, Cultured; Dendrites; Excitatory Amino Acid Agonists; Mice; N-Methylaspartate; Spectrin; Time Factors

1997
Role of calpain- and interleukin-1 beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture.
    Journal of neurochemistry, 1997, Volume: 68, Issue:4

    Topics: Amyloid beta-Peptides; Animals; Calcium; Calpain; Caspase 1; Cell Death; Cells, Cultured; Cysteine Endopeptidases; DNA Fragmentation; Endopeptidases; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Interleukin-1; N-Methylaspartate; Neurotoxins; Peptide Fragments; Pregnancy; Pyramidal Cells; Rats; Staurosporine

1997
NMDA receptor-mediated regulation of AMPA receptor properties in organotypic hippocampal slice cultures.
    Journal of neurochemistry, 1997, Volume: 69, Issue:1

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calpain; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Molecular Weight; N-Methylaspartate; Neuronal Plasticity; Organ Culture Techniques; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Tritium

1997
Neuronal nitric oxide synthase and calmodulin-dependent protein kinase IIalpha undergo neurotoxin-induced proteolysis.
    Journal of neurochemistry, 1997, Volume: 69, Issue:3

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calpain; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Fetus; Kainic Acid; Kinetics; Marine Toxins; N-Methylaspartate; Neurons; Neurotoxins; Nitric Oxide Synthase; Okadaic Acid; Oxocins; Rats; Rats, Sprague-Dawley; Spectrin

1997
Marking synaptic activity in dendritic spines with a calpain substrate exhibiting fluorescence resonance energy transfer.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Feb-29, Volume: 97, Issue:5

    Topics: Amino Acid Sequence; Animals; Biomarkers; Calcium; Calpain; COS Cells; Culture Techniques; Dendrites; Energy Transfer; Fluorescence; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Intracellular Fluid; Long-Term Potentiation; Luminescent Proteins; Microscopy, Fluorescence; Molecular Sequence Data; N-Methylaspartate; Rats; Receptors, Glutamate; Recombinant Fusion Proteins; Spectrin; Spectrometry, Fluorescence; Substrate Specificity; Synaptic Transmission

2000
Integrin-type signaling has a distinct influence on NMDA-induced cytoskeletal disassembly.
    Journal of neuroscience research, 2000, Mar-15, Volume: 59, Issue:6

    Topics: Animals; Animals, Newborn; Calpain; Cytoskeleton; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Integrins; N-Methylaspartate; Rats; Signal Transduction; Spectrin

2000
Calpain-mediated degradation of PSD-95 in developing and adult rat brain.
    Neuroscience letters, 2000, Jun-02, Volume: 286, Issue:2

    Topics: Age Factors; Animals; Animals, Newborn; Brain; Calcium; Calpain; Cells, Cultured; Disks Large Homolog 4 Protein; Excitatory Amino Acid Agonists; Hippocampus; Intracellular Signaling Peptides and Proteins; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission; Synaptosomes

2000
Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death.
    The Journal of biological chemistry, 2000, Jun-02, Volume: 275, Issue:22

    Topics: Animals; Apoptosis; Calpain; Caspases; Cells, Cultured; Cytochrome c Group; Enzyme Activation; Hippocampus; Microscopy, Fluorescence; Mitochondria; N-Methylaspartate; Neurons; Rats

2000
Transient NMDA receptor inactivation provides long-term protection to cultured cortical neurons from a variety of death signals.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Oct-01, Volume: 20, Issue:19

    Topics: Adrenergic beta-Agonists; Animals; Apoptosis; Calcium; Calpain; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glucose; Hypoxia, Brain; Ischemic Preconditioning; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction

2000
Involvement of the secretory pathway for AMPA receptors in NMDA-induced potentiation in hippocampus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Jan-01, Volume: 21, Issue:1

    Topics: Animals; Blotting, Western; Brefeldin A; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calpain; Cross-Linking Reagents; Electric Stimulation; Hippocampus; In Vitro Techniques; Long-Term Potentiation; N-Methylaspartate; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Subcellular Fractions; Synaptic Membranes; Synaptic Transmission; Up-Regulation

2001
Proteolysis of glutamate receptor-interacting protein by calpain in rat brain: implications for synaptic plasticity.
    Journal of neurochemistry, 2001, Volume: 77, Issue:6

    Topics: Animals; Calpain; Carrier Proteins; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Long-Term Potentiation; N-Methylaspartate; Nerve Tissue Proteins; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synapses

2001
Cross-tolerance to otherwise lethal N-methyl-D-aspartate and oxygen-glucose deprivation in preconditioned cortical cultures.
    Neuroscience, 2001, Volume: 107, Issue:4

    Topics: Aniline Compounds; Animals; Biomarkers; Brain Ischemia; Calcium; Calpain; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Female; Fluorescent Antibody Technique; Fluorescent Dyes; Glucose; Ischemic Preconditioning; Microtubule-Associated Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Oxygen; Pregnancy; Rats; Xanthenes

2001
Trophic agents that prevent neuronal apoptosis activate calpain and down-regulate CaMKIV.
    Journal of neurochemistry, 2002, Volume: 81, Issue:2

    Topics: Active Transport, Cell Nucleus; Adaptation, Physiological; Animals; Antibiotics, Antineoplastic; Apoptosis; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Calcium-Calmodulin-Dependent Protein Kinases; Calpain; Cell Survival; Cells, Cultured; Cerebellum; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Exportin 1 Protein; Fatty Acids, Unsaturated; Karyopherins; N-Methylaspartate; Neurons; Phosphorylation; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear

2002
Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation.
    Biochemical and biophysical research communications, 2002, Nov-15, Volume: 298, Issue:5

    Topics: Animals; Calcimycin; Calpain; Cells, Cultured; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Glutamic Acid; Ionomycin; Ionophores; N-Methylaspartate; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurofibrillary Tangles; Neurons; Phosphorylation; Rats; tau Proteins

2002
Activation of mu-calpain in developing cortical neurons following methylmercury treatment.
    Brain research. Developmental brain research, 2003, Apr-14, Volume: 142, Issue:1

    Topics: Animals; Calpain; Cerebral Cortex; Dizocilpine Maleate; Enzyme Activation; Immunoblotting; Immunohistochemistry; Mercury Poisoning, Nervous System; Methylmercury Compounds; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Spectrin

2003
Vulnerability of central neurons to secondary insults after in vitro mechanical stretch.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Sep-15, Volume: 24, Issue:37

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Apoptosis; Brain Injuries; Calpain; Cell Nucleus; Cells, Cultured; Cysteine Endopeptidases; DNA; DNA Fragmentation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; In Situ Nick-End Labeling; In Vitro Techniques; Intracellular Membranes; Membrane Potentials; Mice; Mitochondria; N-Methylaspartate; Neurons; Neurotoxins; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Porphyrins; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Stress, Mechanical; Superoxide Dismutase

2004
Regulation of N-methyl-D-aspartate receptors by calpain in cortical neurons.
    The Journal of biological chemistry, 2005, Jun-03, Volume: 280, Issue:22

    Topics: Animals; Blotting, Western; Calcium; Calpain; Down-Regulation; Dynamins; Endocytosis; Enzyme Inhibitors; Glutamic Acid; Immunoblotting; Ischemia; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Peptides; Rats; Receptors, N-Methyl-D-Aspartate; Time Factors

2005
Calpain and N-methyl-d-aspartate (NMDA)-induced excitotoxicity in rat retinas.
    Brain research, 2005, Jun-07, Volume: 1046, Issue:1-2

    Topics: Animals; Apoptosis; Blotting, Western; Calpain; DNA Fragmentation; Immunohistochemistry; In Situ Nick-End Labeling; Isoenzymes; Male; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases

2005
Negative regulation of neurotransmitter release by calpain: a possible involvement of specific SNAP-25 cleavage.
    Journal of neurochemistry, 2005, Volume: 94, Issue:3

    Topics: Age Factors; Animals; Animals, Newborn; Antibodies; Blotting, Western; Calcium; Calpain; Cells, Cultured; Cerebellum; Chromatography, High Pressure Liquid; Dipeptides; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Glycoproteins; Ionomycin; Ionophores; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Potassium; Rats; Rats, Wistar; Synaptosomal-Associated Protein 25; Time Factors

2005
Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain-dependent manner.
    Journal of neurochemistry, 2005, Volume: 94, Issue:4

    Topics: Animals; Argonaute Proteins; Brain; Calcium; Calpain; Cell Size; Dendrites; Eukaryotic Initiation Factors; Fragile X Mental Retardation Protein; In Vitro Techniques; Male; Mice; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Peptide Fragments; Ribonuclease III; RNA-Binding Proteins; Synapses; Tissue Distribution

2005
Calpain-mediated truncation of dihydropyrimidinase-like 3 protein (DPYSL3) in response to NMDA and H2O2 toxicity.
    Journal of neurochemistry, 2005, Volume: 95, Issue:2

    Topics: Amino Acid Sequence; Animals; Blotting, Western; Calcium; Calpain; Caspase 3; Caspase Inhibitors; Cells, Cultured; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hydrogen Peroxide; Molecular Sequence Data; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Oxidative Stress; Phosphorylation; Rats; Rats, Sprague-Dawley

2005
Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Mar-15, Volume: 26, Issue:11

    Topics: Age Factors; Animals; Biomarkers; Calpain; Dipeptides; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Enzyme Activation; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Gene Expression Regulation, Developmental; Glucose; Hippocampus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; L-Lactate Dehydrogenase; Membrane Proteins; N-Methylaspartate; Neurons; Oxygen; Phenols; Piperidines; Propidium; Protein Subunits; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spectrin; Valine

2006
Calpain product of WT-CRMP2 reduces the amount of surface NR2B NMDA receptor subunit.
    Journal of neurochemistry, 2006, Volume: 98, Issue:4

    Topics: Animals; Biotin; Blotting, Western; Calcium; Calpain; Cells, Cultured; Cerebral Cortex; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Excitatory Amino Acid Agonists; Glutamic Acid; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Membrane Proteins; Mice; N-Methylaspartate; Nerve Tissue Proteins; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2006
Calpain- and caspase-mediated alphaII-spectrin and tau proteolysis in rat cerebrocortical neuronal cultures after ecstasy or methamphetamine exposure.
    The international journal of neuropsychopharmacology, 2007, Volume: 10, Issue:4

    Topics: Amino Acid Chloromethyl Ketones; Animals; Animals, Newborn; Aspartic Acid; Calpain; Caspase Inhibitors; Caspases; Cell Death; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Dipeptides; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Methamphetamine; Microfilament Proteins; Molecular Weight; N-Methyl-3,4-methylenedioxyamphetamine; N-Methylaspartate; Neurons; Peptide Fragments; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; tau Proteins; Time Factors; Vesicular Transport Proteins

2007
Microtubule disruption, not calpain-dependent loss of MAP2, contributes to enduring NMDA-induced dendritic dysfunction in acute hippocampal slices.
    Experimental neurology, 2006, Volume: 202, Issue:2

    Topics: Animals; Calcium; Calpain; Cysteine Proteinase Inhibitors; Dendrites; Dipeptides; Drug Interactions; Evoked Potentials; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; In Vitro Techniques; Male; Mice; Microtubule-Associated Proteins; Microtubules; N-Methylaspartate; Nerve Tissue Proteins; Paclitaxel; Time Factors; Tubulin Modulators

2006
Involvement of nitric oxide synthase and ROS-mediated activation of L-type voltage-gated Ca2+ channels in NMDA-induced DPYSL3 degradation.
    Brain research, 2006, Nov-13, Volume: 1119, Issue:1

    Topics: Animals; Calcium; Calcium Channels, L-Type; Calcium Signaling; Calpain; Cells, Cultured; Cerebral Cortex; Cytoprotection; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate

2006
Comparison of neuroprotective effects of erythropoietin (EPO) and carbamylerythropoietin (CEPO) against ischemia-like oxygen-glucose deprivation (OGD) and NMDA excitotoxicity in mouse hippocampal slice cultures.
    Experimental neurology, 2007, Volume: 204, Issue:1

    Topics: Animals; Animals, Newborn; Brain Ischemia; Calpain; Coloring Agents; Erythropoietin; Excitatory Amino Acid Agonists; Glucose; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; N-Methylaspartate; Neuroprotective Agents; Propidium; Tolonium Chloride

2007
Proteolytic degradation of SCOP in the hippocampus contributes to activation of MAP kinase and memory.
    Cell, 2007, Mar-23, Volume: 128, Issue:6

    Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium; Calpain; Cell Culture Techniques; CREB-Binding Protein; Excitatory Amino Acid Agonists; Hippocampus; Humans; MAP Kinase Signaling System; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neurons; Nuclear Proteins; Phosphoprotein Phosphatases; Potassium Chloride; Rats; Regulatory Elements, Transcriptional; Transcription, Genetic

2007
Calpain-mediated collapsin response mediator protein-1, -2, and -4 proteolysis after neurotoxic and traumatic brain injury.
    Journal of neurotrauma, 2007, Volume: 24, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Animals; Brain; Brain Injuries; Calpain; Caspase 3; Cell Death; Cells, Cultured; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Excitatory Amino Acid Agonists; Hippocampus; Immunoblotting; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; L-Lactate Dehydrogenase; Marine Toxins; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Neurotoxicity Syndromes; Oxocins; Phosphoproteins; Rats; Rats, Sprague-Dawley

2007
PLA(2) signaling is involved in calpain-mediated degradation of synaptic dihydropyrimidinase-like 3 protein in response to NMDA excitotoxicity.
    Neuroscience letters, 2008, Jan-17, Volume: 430, Issue:3

    Topics: Adenylyl Cyclase Inhibitors; Animals; Calpain; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2 Inhibitors; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Neurotoxins; Phospholipases A2; Rats; Signal Transduction; Synapses

2008
Lysosomal release of cathepsins causes ischemic damage in the rat hippocampal slice and depends on NMDA-mediated calcium influx, arachidonic acid metabolism, and free radical production.
    Journal of neurochemistry, 2008, Volume: 106, Issue:1

    Topics: Animals; Arachidonic Acid; Calcium; Calcium Signaling; Calpain; Cathepsin B; Cathepsins; Cell Death; Cell Membrane Permeability; Excitatory Amino Acid Agonists; Extracellular Signal-Regulated MAP Kinases; Free Radicals; Hippocampus; Hypoxia-Ischemia, Brain; Lysosomes; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Organ Culture Techniques; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

2008
Postsynaptic density-95 (PSD-95) and calcineurin control the sensitivity of N-methyl-D-aspartate receptors to calpain cleavage in cortical neurons.
    Molecular pharmacology, 2008, Volume: 74, Issue:2

    Topics: Animals; Calcineurin; Calpain; Cells, Cultured; Cerebral Cortex; Gerbillinae; Hydrolysis; Male; N-Methylaspartate; Neurons; PDZ Domains; Receptors, N-Methyl-D-Aspartate

2008
Inhibition of Calpain Prevents N-Methyl-D-aspartate-Induced Degeneration of the Nucleus Basalis and Associated Behavioral Dysfunction.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 327, Issue:2

    Topics: Animals; Basal Nucleus of Meynert; Benzamides; Calpain; Cognition; Dose-Response Relationship, Drug; Hippocampus; Long-Term Potentiation; Male; Microglia; Motor Activity; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate

2008
Ischemic tolerance following low dose NMDA involves modulation of cellular stress proteins.
    Brain research, 2009, Jan-09, Volume: 1247

    Topics: Animals; Brain; Calpain; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Ischemic Preconditioning; Male; Membrane Proteins; Molecular Chaperones; N-Methylaspartate; Neuroprotective Agents; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Stress, Physiological

2009
Calpain-mediated degradation of G-substrate plays a critical role in retinal excitotoxicity for amacrine cells.
    Journal of neuroscience research, 2009, May-01, Volume: 87, Issue:6

    Topics: Amacrine Cells; Analysis of Variance; Animals; Blotting, Western; Calpain; Cell Death; Cysteine Proteinase Inhibitors; Dipeptides; Immunohistochemistry; In Situ Nick-End Labeling; Leupeptins; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Nerve Tissue Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Retina

2009
Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity.
    Journal of neurochemistry, 2009, Volume: 108, Issue:5

    Topics: Animals; Calpain; Cell Survival; Cells, Cultured; Embryo, Mammalian; Excitatory Amino Acid Agonists; Fibroblasts; Gene Expression Regulation; Hippocampus; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Protein Transport; Rats; RNA, Messenger; RNA, Small Interfering; Transfection

2009
Calpain-mediated N-cadherin proteolytic processing in brain injury.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, May-06, Volume: 29, Issue:18

    Topics: Animals; Animals, Newborn; beta Catenin; Biotinylation; Brain Injuries; Cadherins; Calcium; Calpain; Cells, Cultured; Disease Models, Animal; Dizocilpine Maleate; Embryo, Mammalian; Endocytosis; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Green Fluorescent Proteins; In Vitro Techniques; Ionomycin; Ionophores; Mice; Models, Biological; Mutation; N-Methylaspartate; Neurons; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Signal Transduction; Subcellular Fractions; Transfection; Wnt Proteins

2009
Calcium dysregulation induces apoptosis-inducing factor release: cross-talk between PARP-1- and calpain-signaling pathways.
    Experimental neurology, 2009, Volume: 218, Issue:2

    Topics: Analysis of Variance; Animals; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Calcium; Calpain; Cells, Cultured; Cerebral Cortex; DNA, Complementary; Excitatory Amino Acid Agonists; Genetic Vectors; Green Fluorescent Proteins; Mitochondria; N-Methylaspartate; Neurons; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Signal Transduction; Transfection

2009
Memantine inhibits calpain-mediated truncation of GSK-3 induced by NMDA: implications in Alzheimer's disease.
    Journal of Alzheimer's disease : JAD, 2009, Volume: 18, Issue:4

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Calpain; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Female; Glycogen Synthase Kinase 3; Humans; Inhibitory Concentration 50; Male; Memantine; Middle Aged; N-Methylaspartate; Neurons; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Signal Transduction

2009
A novel calpain inhibitor, ((1S)-1-((((1S)-1-Benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester (SNJ-1945), reduces murine retinal cell death in vitro and in vivo.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:2

    Topics: Administration, Oral; Animals; Calpain; Carbamates; Cell Line; Cell Survival; Glycoproteins; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Retina; Retinal Degeneration; Retinal Ganglion Cells

2010
Neuroprotective effects of C-type natriuretic peptide on rat retinal ganglion cells.
    Investigative ophthalmology & visual science, 2010, Volume: 51, Issue:7

    Topics: Animals; Apoptosis; Atrial Natriuretic Factor; bcl-2-Associated X Protein; bcl-X Protein; Calpain; Cell Count; Cell Survival; Cells, Cultured; Gene Expression Regulation; In Situ Nick-End Labeling; Male; N-Methylaspartate; Natriuretic Agents; Natriuretic Peptide, C-Type; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Atrial Natriuretic Factor; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha

2010
Inhibition of calpain prevents NMDA-induced cell death and beta-amyloid-induced synaptic dysfunction in hippocampal slice cultures.
    British journal of pharmacology, 2010, Volume: 159, Issue:7

    Topics: Amyloid beta-Peptides; Animals; Benzamides; Calpain; Cell Death; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Wistar; Synapses; Synaptic Transmission

2010
Role of the c-Jun N-terminal kinase pathway in retinal excitotoxicity, and neuroprotection by its inhibition.
    Journal of neurochemistry, 2010, Volume: 113, Issue:5

    Topics: Adaptation, Ocular; Animals; Blotting, Western; Calpain; Carrier Proteins; Cell Count; Cell Death; Electroretinography; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Immunohistochemistry; Injections; JNK Mitogen-Activated Protein Kinases; Male; Microfilament Proteins; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Signal Transduction; Vitreous Body

2010
Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions.
    ASN neuro, 2011, Feb-16, Volume: 3, Issue:1

    Topics: Analysis of Variance; Animals; Animals, Newborn; Brain; Brain Injuries; Calpain; Caspase 3; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Gene Expression Regulation; Male; Molecular Weight; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxicity Syndromes; Neurotoxins; Peptide Hydrolases; Protein Isoforms; Rats; tau Proteins

2011
Calpain-mediated degradation of myocyte enhancer factor 2D contributes to excitotoxicity by activation of extrasynaptic N-methyl-D-aspartate receptors.
    The Journal of biological chemistry, 2012, Feb-17, Volume: 287, Issue:8

    Topics: Animals; Calpain; Cell Death; Cell Hypoxia; Cell Survival; Enzyme Activation; Glucose; MEF2 Transcription Factors; N-Methylaspartate; Neurons; Neurotoxins; Proteolysis; Rats; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synapses; Transcription Factors

2012
Calpains are downstream effectors of bax-dependent excitotoxic apoptosis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Feb-01, Volume: 32, Issue:5

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calpain; Cell Line, Tumor; Cells, Cultured; Dipeptides; Excitatory Amino Acid Agonists; Female; Hippocampus; Humans; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Organ Culture Techniques; Pregnancy

2012
Oral administration of crocetin prevents inner retinal damage induced by N-methyl-D-aspartate in mice.
    European journal of pharmacology, 2012, Sep-05, Volume: 690, Issue:1-3

    Topics: Administration, Oral; Animals; Apoptosis; Calpain; Carotenoids; Caspase 3; Cell Count; Cytoprotection; Enzyme Induction; Male; Mice; N-Methylaspartate; Retina; Retinal Ganglion Cells; Vitamin A

2012
Temporal dependence of cysteine protease activation following excitotoxic hippocampal injury.
    Neuroscience, 2012, Oct-11, Volume: 222

    Topics: 2-Amino-5-phosphonovalerate; Animals; Calpain; Cell Death; Cell Survival; Cells, Cultured; Cysteine Proteases; Dipeptides; Enzyme Activation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hippocampus; Immunohistochemistry; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synaptophysin

2012
Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Aug-15, Volume: 32, Issue:33

    Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Calcium; Calcium Ionophores; Calpain; Cycloheximide; Cysteine Proteinase Inhibitors; Dipeptides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Emetine; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Ionomycin; K Cl- Cotransporters; Leupeptins; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Protein Synthesis Inhibitors; Pyramidal Cells; Rats; Rats, Wistar; Statistics, Nonparametric; Symporters; Valine

2012
Dual effect of 17β-estradiol on NMDA-induced neuronal death: involvement of metabotropic glutamate receptor 1.
    Endocrinology, 2012, Volume: 153, Issue:12

    Topics: Animals; Astrocytes; Butadienes; Calpain; Catechols; Cell Death; Cerebral Cortex; Enzyme Inhibitors; Estradiol; Extracellular Signal-Regulated MAP Kinases; Glycine; Mice; Models, Biological; N-Methylaspartate; Neurons; Nitriles; Phosphorylation; Receptors, Estrogen; Receptors, Metabotropic Glutamate

2012
Differential roles for caspase-mediated and calpain-mediated cell death in 1- and 3-week-old rat cortical cultures.
    Neuroreport, 2012, Dec-19, Volume: 23, Issue:18

    Topics: Age Factors; Animals; Animals, Newborn; Calpain; Caspases; Cell Death; Cells, Cultured; Cellular Senescence; Cerebral Cortex; Dose-Response Relationship, Drug; Hydrogen Peroxide; N-Methylaspartate; Rats; Rats, Sprague-Dawley

2012
Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Mar-27, Volume: 33, Issue:13

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Newborn; Biophysics; Brain; Brain Injuries; Bromodeoxyuridine; Calpain; Cell Death; Dendrites; Disease Models, Animal; Electric Stimulation; Embryo, Mammalian; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Intermediate Filament Proteins; Long-Term Potentiation; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Nerve Tissue Proteins; Nestin; Neurons; Patch-Clamp Techniques; Phosphotransferases; Psychomotor Performance; RNA, Messenger; Silver Staining; Transfection; Tyrosine 3-Monooxygenase

2013
Control of synaptic plasticity and memory via suppression of poly(A)-binding protein.
    Neuron, 2013, Apr-24, Volume: 78, Issue:2

    Topics: Adenosine Triphosphatases; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calpain; Cells, Cultured; Conditioning, Psychological; Dactinomycin; Enzyme Inhibitors; Fear; Gene Expression Regulation; Hippocampus; Long-Term Potentiation; Male; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Neurons; Oligodeoxyribonucleotides; Poly(A)-Binding Proteins; Protein Synthesis Inhibitors; Reaction Time; Repressor Proteins; RNA-Binding Proteins; RNA, Messenger; Synapses; Tumor Suppressor Proteins

2013
CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels.
    Cell death & disease, 2014, Apr-10, Volume: 5

    Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calpain; Cells, Cultured; Clonazepam; Cytoprotection; Cytosol; Endoplasmic Reticulum; Intracellular Space; Mitochondria; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Rats, Sprague-Dawley; Sodium-Calcium Exchanger; Thiazepines

2014
Calpain-Mediated Degradation of Drebrin by Excitotoxicity In vitro and In vivo.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Actins; Animals; Calcium; Calpain; Cells, Cultured; Excitatory Amino Acid Agonists; Female; Hippocampus; Humans; Mice; N-Methylaspartate; Neurons; Neuropeptides; Proteolysis; Rats; Rats, Sprague-Dawley

2015
The neuroprotective effect of hesperidin in NMDA-induced retinal injury acts by suppressing oxidative stress and excessive calpain activation.
    Scientific reports, 2017, 07-31, Volume: 7, Issue:1

    Topics: Animals; Apoptosis; Calpain; Cells, Cultured; Disease Models, Animal; Evoked Potentials, Visual; Hesperidin; Male; Mice; N-Methylaspartate; Neuroprotective Agents; Oxidative Stress; Retina; Retinal Diseases; Retinal Ganglion Cells; Treatment Outcome; Tumor Necrosis Factor-alpha

2017
Novel Peptidomic Approach for Identification of Low and High Molecular Weight Tauopathy Peptides Following Calpain Digestion, and Primary Culture Neurotoxic Challenges.
    International journal of molecular sciences, 2019, Oct-21, Volume: 20, Issue:20

    Topics: Animals; Calcimycin; Calpain; Cells, Cultured; Chromatography, Liquid; Marine Toxins; Mice; Mice, Transgenic; Molecular Weight; N-Methylaspartate; Nanotechnology; Neurons; Oxocins; Peptides; Phosphorylation; Primary Cell Culture; Proteolysis; Rats; Spectrometry, Mass, Electrospray Ionization; Staurosporine; Tandem Mass Spectrometry; tau Proteins

2019
Over-activation of NMDA receptors promotes ABCA1 degradation and foam cell formation.
    Biochimica et biophysica acta. Molecular and cell biology of lipids, 2020, Volume: 1865, Issue:10

    Topics: Apolipoprotein A-I; Atherosclerosis; ATP Binding Cassette Transporter 1; Biological Transport; Calcium; Calpain; Cholesterol, HDL; Foam Cells; Gene Expression Regulation; Humans; Lipid Metabolism; Liver X Receptors; Macrophages; N-Methylaspartate; NF-kappa B; Proteolysis; Receptors, N-Methyl-D-Aspartate

2020
A novel cell-penetrating peptide targeting calpain-cleavage of PSD-95 induced by excitotoxicity improves neurological outcome after stroke.
    Theranostics, 2021, Volume: 11, Issue:14

    Topics: Animals; Brain Ischemia; Calpain; Cell Survival; Cell-Penetrating Peptides; Cells, Cultured; Disease Models, Animal; Disks Large Homolog 4 Protein; Down-Regulation; Excitatory Amino Acid Agonists; HEK293 Cells; Humans; Male; Mice; Mice, Inbred BALB C; Movement Disorders; N-Methylaspartate; Neurons; Neuroprotection; Stroke

2021
MST1 mediates the N-methyl-D-aspartate-induced excitotoxicity in mouse cortical neurons.
    Cellular and molecular life sciences : CMLS, 2021, Dec-30, Volume: 79, Issue:1

    Topics: Amino Acid Sequence; Animals; Calpain; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Mice, Inbred C57BL; Mutation; N-Methylaspartate; Neurons; Neurotoxins; Protein Serine-Threonine Kinases; Protein Transport; Substrate Specificity

2021