n-methylaspartate and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one

Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Carbazoles; Caspase 3; Caspases; Cells, Cultured; Cerebellum; Chromones; Enzyme Inhibitors; Ethanol; Indole Alkaloids; Insulin-Like Growth Factor I; Morpholines; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Signal Transduction

Topics: Adenosine Triphosphate; Androstadienes; Animals; Apoptosis; Buthionine Sulfoximine; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Flavonoids; Hypoglycemic Agents; Insulin; Insulin Antagonists; Insulin-Like Growth Factor I; Iron; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; N-Methylaspartate; Necrosis; Neocortex; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorus Radioisotopes; Phosphorylation; Staurosporine; Wortmannin

Topics: Amino Acids; Animals; Astrocytes; Blotting, Northern; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Chromones; Corpus Striatum; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Flavonoids; Glycine; Immunoblotting; Immunohistochemistry; Male; MAP Kinase Signaling System; Mice; Morpholines; N-Methylaspartate; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Transforming Growth Factor beta; Transforming Growth Factor beta1

Topics: Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Cells, Cultured; Cerebellum; Chromones; Dizocilpine Maleate; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Indole Alkaloids; Morpholines; N-Methylaspartate; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Signal Transduction

Topics: Androstadienes; Animals; Butadienes; Chromones; Disks Large Homolog 4 Protein; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanylate Kinases; Hippocampus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Long-Term Potentiation; Membrane Proteins; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Morpholines; N-Methylaspartate; Nerve Tissue Proteins; Nitriles; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Wortmannin

Topics: Animals; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Butadienes; Carbazoles; Chromones; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Glutamic Acid; Indole Alkaloids; Mitogen-Activated Protein Kinase Kinases; Morpholines; N-Methylaspartate; Neurons; Neuroprotective Agents; Nitriles; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptor, trkB; RNA, Messenger; Signal Transduction

Topics: Animals; Blotting, Western; Brain; Brain Ischemia; Cell Death; Chromones; Dimethyl Sulfoxide; Disease Models, Animal; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Free Radical Scavengers; Ischemic Preconditioning; Ketamine; Male; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase Kinase Kinase 11; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Morpholines; N-Methylaspartate; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Receptors, N-Methyl-D-Aspartate; Reperfusion; Time Factors

Topics: Animals; Apoptosis; Brain; Cells, Cultured; Cerebral Cortex; Chromones; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Morpholines; N-Methylaspartate; Neurons; Neuroprotective Agents; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

Topics: 4-Aminopyridine; Amides; Animals; Animals, Newborn; Bicuculline; Brain-Derived Neurotrophic Factor; Butadienes; Cells, Cultured; Cerebral Cortex; Chlorocebus aethiops; Chromones; COS Cells; Cysteine-Rich Protein 61; Gene Expression Regulation; Genes, fos; Hippocampus; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; N-Methylaspartate; Neurons; Nitriles; Potassium Chloride; Prosencephalon; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyramidal Cells; Pyridines; Rats; Rats, Sprague-Dawley; RNA Interference; Serum Response Factor; Signal Transduction; Synaptic Transmission; Transcription Factors; Transcription, Genetic; Transfection

Topics: Analysis of Variance; Animals; Avoidance Learning; Basal Nucleus of Meynert; Behavioral Symptoms; Choline O-Acetyltransferase; Chromones; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Maze Learning; Mice; Mice, Inbred C57BL; Morpholines; N-Methylaspartate; Neurodegenerative Diseases; Reaction Time

Topics: Adenosine Triphosphate; Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Cerebellum; Chromones; Cytoplasmic Granules; Glycogen Synthase Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; N-Methylaspartate; Neurons; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P2; Receptors, Purinergic P2X7

Topics: Animals; Antibodies, Monoclonal; Calcium; Cell Death; Chromones; Cytokine Receptor gp130; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Interleukin-6; Janus Kinases; MAP Kinase Signaling System; Morpholines; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Phosphatidylinositol 3-Kinases; Phospholipases A2, Cytosolic; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor; Tyrphostins; Up-Regulation

Topics: Androstadienes; Animals; Cell Count; Chromones; Endothelial Cells; Intravitreal Injections; Male; Morpholines; N-Methylaspartate; Protein Kinase Inhibitors; Rats; Retinal Degeneration; Retinal Ganglion Cells; Wortmannin

Topics: Animals; Antibodies, Blocking; Blotting, Western; Calcium; Chromones; Enzyme Activation; Epitopes; Excitatory Amino Acid Agonists; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; In Vitro Techniques; Male; Morpholines; N-Methylaspartate; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; tau Proteins

Topics: Action Potentials; Animal Feed; Animals; Chromones; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Female; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Long-Term Potentiation; Male; Mice, Inbred C57BL; Microelectrodes; Morpholines; N-Methylaspartate; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Simvastatin; Tissue Culture Techniques