n-methylaspartate has been researched along with 1-hydroxy-3-amino-2-pyrrolidone in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (24.32) | 18.7374 |
| 1990's | 24 (64.86) | 18.2507 |
| 2000's | 4 (10.81) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Pittaluga, A; Raiteri, M | 1 |
| Lodge, D; Millar, JD; Pralong, E | 1 |
| Kemp, JA; Priestley, T | 1 |
| Ascher, P; Henderson, G; Johnson, JW | 1 |
| Millan, MJ | 1 |
| Taylor, CP; Vartanian, MG | 1 |
| Britt, M; Chapdelaine, MJ; Keith, RA; LaMonte, D; Mangano, TJ; Patel, J; Powel, RJ; Pullan, LM; Stumpo, RJ; Warwick, PJ | 1 |
| Cler, JA; Emmett, MR; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 1 |
| Keith, R; Patel, J; Salama, A; Thompson, C; Zinkand, WC | 1 |
| Donald, AE; Foster, AC; Hutson, PH; Iversen, LL; Iversen, SD; Kemp, JA; Leeson, PD; Marshall, GR; Oles, RJ; Singh, L | 1 |
| Colpaert, FC; Koek, W | 1 |
| Cler, J; Emmett, MR; Iyengar, S; Mick, S; Oei, E; Rao, TS; Wood, PL | 1 |
| Harris, KM; Miller, RJ; Reynolds, IJ | 1 |
| Cler, J; Emmett, MR; Iyengar, S; Mick, S; Rao, TS; Wood, PL | 1 |
| Drejer, J; Honoré, T; Jensen, LH; Sheardown, MJ; Stidsen, CE | 1 |
| Keith, RA; Klika, AB; Mangano, TJ; Meiners, BA; Patel, J; Salama, AI; Stumpo, RJ | 1 |
| Drejer, J; Honoré, T; Nielsen, EO; Sheardown, M | 1 |
| Johnston, MV; McDonald, JW; Silverstein, FS; Uckele, J | 1 |
| Crawford, M; Roberts, PJ | 1 |
| Fletcher, EJ; Lodge, D | 1 |
| Perkins, MN; Stone, TW | 1 |
| Mikuni, M; Saitoh, K; Shinno, H; Takahashi, K; Tomita, U; Yamawaki, S | 1 |
| Little, HJ; Rabbani, M; Wright, EJ | 1 |
| Davis, R; Klinger, P; Xu, X | 1 |
| Carlsson, A; Carlsson, ML; Engberg, G | 1 |
| Aronstam, RS; Dennison, RL; Martin, DC | 1 |
| Hunter, JC; Singh, L | 1 |
| Hughes, J; Oles, R; Poat, J; Woodburn, VL; Woodruff, GN | 1 |
| Coyle, JT; Handen, JS; Montgomery, DT; Puttfarcken, PS; Werling, LL | 1 |
| Cler, JA; Cordi, AA; Dappen, MS; Emmett, MR; Gray, NM; Iyengar, S; Mick, SJ; Monahan, JB; Rao, TS; Wood, PL | 1 |
| Barks, JD; Liu, XH; Silverstein, FS; Sun, R | 1 |
| Kanthasamy, A; Kanthasamy, AG; Matsumoto, RR; Truong, DD; Vu, TQ | 1 |
| Mancini, L; Mennini, T; Reggiani, A; Trist, D | 1 |
| Chen, L; Muhlhauser, M; Yang, CR | 1 |
| Chatterjee, SS; Hilgert, M; Klein, J; Nawrath, H; Rupp, J; Weichel, O | 1 |
| Carnovali, F; Cervo, L; Cocco, A | 1 |
37 other study(ies) available for n-methylaspartate and 1-hydroxy-3-amino-2-pyrrolidone
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
N-methyl-D-aspartic acid (NMDA) and non-NMDA receptors regulating hippocampal norepinephrine release. III. Changes in the NMDA receptor complex induced by their functional cooperation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Dizocilpine Maleate; Hippocampus; Magnesium; Male; N-Methylaspartate; Norepinephrine; Pyrrolidinones; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1992 |
Specificity and potency of N-methyl-D-aspartate glycine site antagonists and of mephenesin on the rat spinal cord in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Glycine; Ibotenic Acid; Indoles; Kynurenic Acid; Mephenesin; N-Methylaspartate; Pyrrolidinones; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1992 |
Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-methyl-D-aspartate receptor agonist responses in rat cultured cortical neurons.
Topics: Animals; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Osmolar Concentration; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate; Sodium | 1991 |
Competitive antagonists and partial agonists at the glycine modulatory site of the mouse N-methyl-D-aspartate receptor.
Topics: Action Potentials; Animals; Brain; Cells, Cultured; Cerebral Cortex; Cycloserine; Diencephalon; Glycine; Ion Channels; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate | 1990 |
Antagonists at the NMDA recognition site and blockers of the associated ion channel induce spontaneous tail-flicks in the rat.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ion Channels; Ketamine; Male; N-Methylaspartate; Organophosphorus Compounds; Phencyclidine; Pipecolic Acids; Piperazines; Piperidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Different stereoselectivity of the enantiomers of HA-966 (3-amino-1-hydroxy-2-pyrrolidinone) for neuroprotective and anticonvulsant actions in vivo.
Topics: Animals; Anticonvulsants; Ataxia; Electroshock; N-Methylaspartate; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 1991 |
Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-methyl-D-aspartate receptor complex.
Topics: Allosteric Site; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Hippocampus; Ileum; Isometric Contraction; Kinetics; Male; Muscle, Smooth; N-Methylaspartate; Neurons; Norepinephrine; Pyrrolidinones; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Synaptosomes | 1990 |
6,7-Dinitroquinoxaline-2,3-dione and 6-nitro,7-cyanoquinoxaline-2,3-dione antagonize responses mediated by N-methyl-D-aspartate and NMDA-associated glycine recognition sites in vivo: measurements of cerebellar cyclic-GMP.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cerebellum; Cyclic AMP; Glycine; Harmaline; Kinetics; Male; Mice; N-Methylaspartate; Pyrrolidinones; Quinoxalines; Quisqualic Acid; Serine | 1990 |
Role of glycine in the N-methyl-D-aspartate-mediated neuronal cytotoxicity.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Serine | 1990 |
Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.
Topics: 4-Butyrolactone; Acoustic Stimulation; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dopamine; Furans; Glycine; In Vitro Techniques; Isomerism; Kinetics; Male; Membrane Potentials; Mice; Mice, Inbred DBA; Motor Activity; N-Methylaspartate; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reference Values; Seizures; Serotonin | 1990 |
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; Kainic Acid; Kynurenic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Oxadiazoles; Phencyclidine; Pyrrolidinones; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
In vivo antagonism of agonist actions at N-methyl-D-aspartate and N-methyl-D-aspartate-associated glycine receptors in mouse cerebellum: studies of 1-hydroxy-3-aminopyrrolidone-2.
Topics: Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Male; Mice; N-Methylaspartate; Pyrrolidinones; Receptors, Glycine; Receptors, Neurotransmitter | 1990 |
NMDA receptor antagonists that bind to the strychnine-insensitive glycine site and inhibit NMDA-induced Ca2+ fluxes and [3H]GABA release.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Calcium; Desipramine; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Ketamine; Kynurenine; Membranes; N-Methylaspartate; Piperazines; Pyrrolidinones; Radioligand Assay; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1989 |
In vivo modulation of the N-methyl-D-aspartate receptor complex by D-serine: potentiation of ongoing neuronal activity as evidenced by increased cerebellar cyclic GMP.
Topics: Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Cycloserine; Dibenzocycloheptenes; Dizocilpine Maleate; Male; Mice; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1989 |
A potent antagonist of the strychnine insensitive glycine receptor has anticonvulsant properties.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Cortical Spreading Depression; Female; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pregnancy; Pyrrolidinones; Quinoxalines; Rats; Receptors, Glycine; Receptors, Neurotransmitter; Seizures; Strychnine | 1989 |
HA-966 acts at a modulatory glycine site to inhibit N-methyl-D-aspartate-evoked neurotransmitter release.
Topics: Animals; Aspartic Acid; Binding Sites; Dibenzocycloheptenes; Dizocilpine Maleate; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Piperazines; Pyrrolidinones; Rats; Strychnine | 1989 |
Glycine reverses the effect of HA-966 on NMDA responses in cultured rat cortical neurons and in chick retina.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Chickens; Cortical Spreading Depression; Glycine; In Vitro Techniques; N-Methylaspartate; Neurons; Pyrrolidinones; Rats; Retina | 1989 |
HA-966 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces N-methyl-D-aspartate (NMDA)-mediated brain damage.
Topics: Animals; Animals, Newborn; Aspartic Acid; Brain Diseases; Corpus Striatum; N-Methylaspartate; Oxadiazoles; Pyrrolidinones; Quisqualic Acid; Rats; Rats, Inbred Strains | 1989 |
1-Hydroxy-3-aminopyrrolid-2-one (HA-966) and kynurenate antagonize N-methyl-D-aspartate induced enhancement of [3H]dopamine release from rat striatal slices.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; Drug Antagonism; Kynurenic Acid; Male; N-Methylaspartate; Potassium; Pyrrolidinones; Rats; Rats, Inbred Strains | 1989 |
Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-aminopyrrolidone-2 (HA-966) but not by D-2-amino-5-phosphonovalerate (D-AP5) on rat cortical slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Evoked Potentials; Glycine; In Vitro Techniques; N-Methylaspartate; Pyrrolidinones; Rats; Valine | 1988 |
Pharmacology and regional variations of quinolinic acid-evoked excitations in the rat central nervous system.
Topics: Animals; Aspartic Acid; Central Nervous System; Evoked Potentials; Glutamates; Male; N-Methylaspartate; Oxadiazoles; Pyridines; Pyrrolidinones; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1983 |
Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cell Line; Cycloleucine; Dizocilpine Maleate; Glioma; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Ion Channels; Kainic Acid; Kinetics; Magnesium Chloride; N-Methylaspartate; Neurotoxins; Pyrrolidinones; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Signal Transduction; Tumor Cells, Cultured | 1994 |
Tolerance to competitive NMDA antagonists, but no crosstolerance with barbiturates.
Topics: 2-Amino-5-phosphonovalerate; Animals; Ataxia; Behavior, Animal; Dizocilpine Maleate; Drug Tolerance; Hypnotics and Sedatives; Male; Mice; Motor Activity; N-Methylaspartate; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome | 1995 |
Comparative anterograde amnestic and anticonvulsant effects of two types of NMDA receptor antagonists: MK-801 and HA-966.
Topics: Amnesia; Animals; Anticonvulsants; Conditioning, Classical; Dizocilpine Maleate; Fear; Goldfish; N-Methylaspartate; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate | 1995 |
Effects of D-cycloserine and (+)-HA-966 on the locomotor stimulation induced by NMDA antagonists and clonidine in monoamine-depleted mice.
Topics: Allosteric Site; Animals; Biogenic Monoamines; Clonidine; Cycloserine; Dose-Response Relationship, Drug; Mice; Motor Activity; N-Methylaspartate; Pyrrolidinones; Receptors, Adrenergic, alpha-2; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1994 |
Volatile anesthetics inhibit NMDA-stimulated 45Ca uptake by rat brain microvesicles.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Calcium; Calcium Radioisotopes; Dizocilpine Maleate; Enflurane; Glycine; Halothane; Kinetics; Male; Microcirculation; N-Methylaspartate; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Role of excitatory amino acid receptors in the mediation of the nociceptive response to formalin in the rat.
Topics: Analgesics; Animals; Formaldehyde; Inflammation; Male; N-Methylaspartate; Nociceptors; Pain Measurement; Pipecolic Acids; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1994 |
Anticonvulsant agents, dizocilpine maleate, enadoline and HA 966 have different effects on N-methyl-DL-aspartate-induced immediate early gene induction in mice.
Topics: Animals; Anticonvulsants; Benzofurans; Brain; Brain Chemistry; Dizocilpine Maleate; Gene Expression; Genes, Immediate-Early; In Situ Hybridization; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Pyrrolidines; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Silver Staining | 1993 |
N-acetyl-aspartylglutamate modulation of N-methyl-D-aspartate-stimulated [3H]norepinephrine release from rat hippocampal slices.
Topics: Animals; Calcium Channel Blockers; Dipeptides; Glycine; Hippocampus; In Vitro Techniques; N-Methylaspartate; Norepinephrine; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Indole-2-carboxylates, novel antagonists of the N-methyl-D-aspartate (NMDA)-associated glycine recognition sites: in vivo characterization.
Topics: Animals; Brain; Cerebellum; Cyclic GMP; Harmaline; Indoleacetic Acids; Kynurenic Acid; Ligands; Male; Mice; N-Methylaspartate; Pyrrolidinones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1993 |
gp120, a human immunodeficiency virus-1 coat protein, augments excitotoxic hippocampal injury in perinatal rats.
Topics: Animals; Animals, Newborn; Autoradiography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; HIV Envelope Protein gp120; Injections; Male; N-Methylaspartate; Neurotoxins; Piperazines; Pyrrolidinones; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Neuroprotective effects of the strychnine-insensitive glycine site NMDA antagonist (R)-HA-966 in an experimental model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Brain; Dopamine; Dopamine Agents; Drug Resistance; Excitatory Amino Acid Agonists; Glycine Agents; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Neuroprotective Agents; Parkinson Disease, Secondary; Pyrrolidinones; Stereoisomerism; Strychnine | 1997 |
GV 150526A, 7-Cl-kynurenic acid and HA 966 antagonize the glycine enhancement of N-methyl-D-aspartate-induced [3H]noradrenaline and [3H]dopamine release.
Topics: Animals; Dopamine; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Indoles; Kynurenic Acid; Male; N-Methylaspartate; Neostriatum; Norepinephrine; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Synaptosomes | 1997 |
Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo.
Topics: Amino Acid Transport Systems, Neutral; Animals; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glycine; Glycine Plasma Membrane Transport Proteins; Iontophoresis; Male; N-Methylaspartate; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Prefrontal Cortex; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sarcosine; Serine | 2003 |
Excitotoxic hippocampal membrane breakdown and its inhibition by bilobalide: role of chloride fluxes.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Calcium; Calcium Isotopes; Cell Membrane; Chlorides; Choline; Cyclopentanes; Diterpenes; Diuretics; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Furans; Furosemide; Ginkgolides; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Potassium; Pyrrolidinones; Rats; Rats, Wistar; Synaptosomes | 2003 |
Effects on cocaine and food self-administration of (+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, in rats.
Topics: Analysis of Variance; Animals; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Excitatory Amino Acid Agonists; Food; Glycine; Male; N-Methylaspartate; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Time Factors | 2004 |