Page last updated: 2024-08-23

n-methyl-n-(1-methyl-4-pyrrolidino-2-butynyl)acetamide and oxotremorine

n-methyl-n-(1-methyl-4-pyrrolidino-2-butynyl)acetamide has been researched along with oxotremorine in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19906 (54.55)18.7374
1990's5 (45.45)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hacksell, U; Nilsson, BM; Vargas, HM1
Chidester, CG; Collins, RJ; Francis, JW; Heier, RF; Moon, MW; Morris, JK; Russell, RR; Sage, GP; Sethy, VH1
Kramss, RH; Mangano, RM; Rusinko, A; Trybulski, EJ1
Ringdahl, B2
Kramss, RH; Mangano, RM; Trybulski, EJ; Zhang, J1
Abuh, YF; Dokas, LA; Dunbar, PG; Hacksell, U; Hoss, W; Messer, WS; Ngur, DO; Nilsson, BM; Ting, SM1
Hacksell, U; Lundkvist, JR; Ringdahl, B1
Bartfai, T; Consolo, S; Engström, C; Ladinsky, H; Undén, A1
Ehlert, FJ1
Francis, JW; Ruppel, PL; Russell, RR; Sethy, VH1

Other Studies

11 other study(ies) available for n-methyl-n-(1-methyl-4-pyrrolidino-2-butynyl)acetamide and oxotremorine

ArticleYear
Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.
    Journal of medicinal chemistry, 1992, Aug-21, Volume: 35, Issue:17

    Topics: Animals; Cerebral Cortex; Guinea Pigs; Ileum; Imidazoles; Molecular Structure; Muscarinic Antagonists; Muscle Contraction; Oxotremorine; Parasympathomimetics; Pyrrolidines; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Structure-Activity Relationship; Urea

1992
Cholinergic activity of acetylenic imidazoles and related compounds.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:8

    Topics: Acetylene; Animals; Brain; Imidazoles; Mice; Molecular Structure; Muscarinic Antagonists; Oxotremorine; Rats; Receptors, Muscarinic; Salivation; Structure-Activity Relationship; Tears; Tremor; X-Ray Diffraction

1991
Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogues of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5).
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:12

    Topics: Animals; Binding, Competitive; Cerebral Cortex; Chemical Phenomena; Chemistry; Dioxolanes; Guanylyl Imidodiphosphate; Magnetic Resonance Spectroscopy; Male; Molecular Conformation; Molecular Structure; Myocardium; Parasympathomimetics; Pirenzepine; Pyrrolidines; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Stereoisomerism; Structure-Activity Relationship

1990
5-Methyl-2-pyrrolidone analogues of oxotremorine as selective muscarinic agonists.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:3

    Topics: Analgesia; Animals; Body Temperature; Carbachol; Guinea Pigs; In Vitro Techniques; Mice; Muscle, Smooth; Oxotremorine; Parasympathomimetics; Pyrrolidinones; Salivation; Urinary Bladder

1988
The synthesis and biochemical pharmacology of enantiomerically pure methylated oxotremorine derivatives.
    Journal of medicinal chemistry, 1993, Nov-12, Volume: 36, Issue:23

    Topics: Animals; Binding, Competitive; Cerebral Cortex; Guanylyl Imidodiphosphate; Male; Methylation; N-Methylscopolamine; Oxotremorine; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Muscarinic; Scopolamine Derivatives; Stereoisomerism

1993
Stereoselective binding and activity of oxotremorine analogs at muscarinic receptors in rat brain.
    Chirality, 1992, Volume: 4, Issue:8

    Topics: Adenylyl Cyclases; Animals; Autoradiography; Brain; Image Processing, Computer-Assisted; In Vitro Techniques; Kinetics; Oxotremorine; Parasympathomimetics; Pyrrolidines; Rats; Receptors, Muscarinic; Stereoisomerism

1992
Conformationally restricted analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:4

    Topics: Animals; Biological Assay; Cerebral Cortex; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; Mice; Molecular Conformation; Muscle Contraction; N-Methylscopolamine; Oxotremorine; Parasympathomimetics; Pyrrolidines; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Structure-Activity Relationship; Tremor

1989
BM-5, a centrally active partial muscarinic agonist with low tremorogenic activity. In vivo and in vitro studies.
    Psychopharmacology, 1987, Volume: 91, Issue:2

    Topics: Acetylcholine; Animals; Body Temperature; Brain; Choline; Dose-Response Relationship, Drug; In Vitro Techniques; Mice; Oxotremorine; Parasympathomimetics; Pyrrolidines; Rats; Salivation; Tremor

1987
Gallamine allosterically antagonizes muscarinic receptor-mediated inhibition of adenylate cyclase activity in the rat myocardium.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:2

    Topics: Adenylyl Cyclase Inhibitors; Algorithms; Animals; Dose-Response Relationship, Drug; Gallamine Triethiodide; Heart; Male; Myocardium; N-Methylscopolamine; Oxotremorine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives

1988
Dual effect of N-methyl-N-(1-methyl-4-pyrolidino)-2-butyl)acetamide on release of (3H)-acetylcholine from the rat hippocampal slices.
    Neuropharmacology, 1988, Volume: 27, Issue:11

    Topics: Acetylcholine; Animals; Atropine; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Oxotremorine; Parasympathomimetics; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic

1988
Selectivity of partial agonists related to oxotremorine based on differences in muscarinic receptor reserve between the guinea pig ileum and urinary bladder.
    Molecular pharmacology, 1987, Volume: 31, Issue:4

    Topics: Animals; Carbachol; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; Kinetics; Male; Mathematics; Oxotremorine; Pirenzepine; Pyrrolidines; Receptors, Muscarinic; Spasm; Structure-Activity Relationship; Urinary Bladder

1987