Compounds > n-methyl-3,4-methylenedioxyamphetamine

n-methyl-3,4-methylenedioxyamphetamine and paroxetine

n-methyl-3,4-methylenedioxyamphetamine has been researched along with paroxetine in 68 studies

Research

Studies (68)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (4.41)	18.7374
1990's	31 (45.59)	18.2507
2000's	25 (36.76)	29.6817
2010's	9 (13.24)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Dansette, PM; Fontana, E; Poli, SM	1
Ben-Daniel, R; Brust, P; Deuther-Conrad, W; Mishani, E; Scheunemann, M; Steinbach, J	1
Katz, JL; Martello, AL; Martello, MB; Ricaurte, GA	1
Culp, S; DeSouza, EB; Lehmann, J; Zaczek, R	1
Colpaert, FC; Millan, MJ	1
Battaglia, G; de Souza, EB; Kuhar, MJ; Sharkey, J	1
Kelly, PA; McBean, DE; Sharkey, J	1
Goromaru, T; Hashimoto, K	1
Arora, RC; Meltzer, HY; Nash, JF; Schreiber, MA	1
Brewster, WK; Johnson, MP; Nichols, DE; Oberlender, R; Riggs, RM	1
Hekmatpanah, CR; Peroutka, SJ	1
Peroutka, SJ; Wagner, J	1
Ricaurte, GA; Scheffel, U	1
Battaglia, G; De Souza, EB; Kuhar, MJ; Molliver, ME; O'Hearn, E; Yeh, SY	1
Johnson, MP; Nichols, DE	1
Hekmatpanah, CR; McKenna, DJ; Peroutka, SJ	1
Nichols, DE; Sprague, JE	1
Colado, MI; Green, AR; Williams, JL	1
Azmitia, EC; Kramer, HK; Poblete, JC	1
Hatzidimitriou, G; Katz, JL; Martello, AL; Ricaurte, GA; Scanzello, CR	1
Kelly, PA; Seckl, JR; Sharkey, J; Yau, JL	1
Goromaru, T; Hashimoto, K; Hirai, K; Maeda, H	1
Brodkin, J; Malyala, A; Nash, JF	1
Colado, MI; Green, AR	1
Johnson, MP; Nichols, DE; Schmidt, CJ; Sprague, JE	1
Colado, MI; Granados, R; Green, AR; Murray, TK; O'Shea, E	1
Dantendorfer, K; Maierhofer, D; Windhaber, J	1
Colado, MI; Esteban, B; Granados, R; Green, AR; O'Shea, E	5
Colado, MI; Esteban, B; Granados, R; Green, AR; Martín, AB; O'Shea, E	1
Kristensen, AS; Mortensen, OV; Rudnick, G; Wiborg, O	1
Rink, J; Stein, DJ	1
Aguirre, N; Barrionuevo, M; Del Río, J; Lasheras, B; Ramírez, MJ	1
Aguirre, N; Barrionuevo, M; Del Río, JD; Lasheras, B	1
Aguirre, N; Hervías, I; Lasheras, B	1
Hashimoto, K; Higuchi, T; Iyo, M; Minabe, Y; Shirayama, Y; Watanabe, K	1
Laverty, R; Russell, BR	1
Connor, TJ; Dennedy, MC; Harkin, A; Kelly, JP	1
Connor, TJ; Harkin, A; Kelly, JP; Leonard, BE; Mulrooney, J	1
Camarero, J; Colado, MI; Esteban, B; Green, AR; Peter, MJ; Sanchez, V	1
Dannals, RF; Hilton, J; Mathews, WB; McCann, UD; Owonikoko, T; Ravert, HT; Ricaurte, GA; Scheffel, U; Szabo, Z; Wilson, AA	1
Easton, N; Fry, JR; Green, AR; Marsden, CA; O'Shea, E	1
Boot, BP; McCann, UD; Mechan, AO; Ricaurte, GA	1
Kelly, PA; McBean, DE; Olverman, HJ; Quate, L; Ritchie, IM	1
Bull, EJ; Fone, KC; Hutson, PH	1
Bacosi, A; de la Torre, R; Di Carlo, S; Farré, M; Ortuño, J; Pacifici, R; Pichini, S; Roset, PN; Segura, J; Segura, M; Zuccaro, P	1
Cole, JC; Marsden, CA; O'Shea, E; Sumnall, HR	1
de la Torre, R; Farré, M; Ortuño, J; Pacifici, R; Peiró, AM; Pichini, S; Ramírez, A; Roset, PN; Segura, J; Segura, M; Zuccaro, P	1
Ando, RD; Bagdy, G; Benko, A; Ferrington, L; Kelly, PA; Kirilly, E	2
Camarero, J; Colado, MI; Escobedo, I; Green, AR; O'Shea, E; Orio, L; Sanchez, V	1
Callaghan, PD; Daws, LC; Farrand, K; Hughes, P; Irvine, RJ; Salem, A	1
Abanades, S; de la Torre, R; Farré, M; O'Mathúna, B; Peiró, AM; Roset, PN; Segura, M; Torrens, M	1
Daniela, E; Gittings, D; Hely, L; Lake, B; Mash, DC; Schenk, S	1
Durkin, S; Harkin, A; Prendergast, A	1
Hasegawa, R; Ikeda, K; Karasawa, J; Tamura, K; Yamamoto, H; Yamamoto, T; Yasumoto, S	1
Colado, MI; Izco, M; Llopis, N; O'Shea, E; Orio, L; Torres, E	1
Blokland, A; Dawson, N; Ferrington, L; Kelly, PA; Prickaerts, J; Steinbusch, HW; van Donkelaar, EL	1
Borcel, E; Colado, MI; Gutierrez-Lopez, MD; Mayado, A; O'Shea, E; Peraile, I; Torres, E	1
Drummer, OH; Gerostamoulos, D; Pilgrim, JL	1
Adori, C; Andó, RD; Bagdy, G; Ferrington, L; Hunyady, L; Kelly, PA; Szekeres, M; Vas, S	1
Abad, S; Camarasa, J; Escubedo, E; Pubill, D; Torres, I	1
Arthur, EJ; Diffenderfer, LE; Furge, LL; Holton, JM; Hsi, DJ; Livezey, M; Nagy, LD	1
Camarasa, J; Escubedo, E; Garcia-Ratés, S; Pubill, D	1
Camarasa, J; Ciudad-Roberts, A; Escubedo, E; Pubill, D	1

Reviews

1 review(s) available for n-methyl-3,4-methylenedioxyamphetamine and paroxetine

Article	Year
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Current drug metabolism, 2005, Volume: 6, Issue:5 Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic	2005

Trials

3 trial(s) available for n-methyl-3,4-methylenedioxyamphetamine and paroxetine

Article	Year
Paroxetine inhibits acute effects of 3,4-methylenedioxymethamphetamine on the immune system in humans. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:1 Topics: Adult; Cross-Over Studies; Double-Blind Method; Drug Interactions; Humans; Immune System; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Selective Serotonin Reuptake Inhibitors; Serotonin Agents; Time Factors	2004
Contribution of cytochrome P450 2D6 to 3,4-methylenedioxymethamphetamine disposition in humans: use of paroxetine as a metabolic inhibitor probe. Clinical pharmacokinetics, 2005, Volume: 44, Issue:6 Topics: Adult; Area Under Curve; Biotransformation; Cross-Over Studies; Cytochrome P-450 CYP2D6; Double-Blind Method; Half-Life; Hallucinogens; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Selective Serotonin Reuptake Inhibitors	2005
Pharmacological interaction between 3,4-methylenedioxymethamphetamine (ecstasy) and paroxetine: pharmacological effects and pharmacokinetics. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 323, Issue:3 Topics: Adult; Blood Pressure; Body Temperature; Cross-Over Studies; Cytochrome P-450 CYP2D6; Double-Blind Method; Drug Interactions; Hallucinogens; Heart Rate; Humans; Male; Metabolic Clearance Rate; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Psychiatric Status Rating Scales; Psychomotor Performance; Pupil; Selective Serotonin Reuptake Inhibitors	2007

Other Studies

64 other study(ies) available for n-methyl-3,4-methylenedioxyamphetamine and paroxetine

Article	Year
Carbon-11 labeled indolylpropylamine analog as a new potential PET agent for imaging of the serotonin transporter. Bioorganic & medicinal chemistry, 2008, Jun-15, Volume: 16, Issue:12 Topics: Animals; Carbon Radioisotopes; Cell Line; Humans; Indoles; Isoquinolines; Isotope Labeling; Ligands; Positron-Emission Tomography; Propylamines; Rats; Rats, Inbred Strains; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship	2008
Lasting effects of (+-)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: neurochemical observations. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; Animals; Brain; Cell Membrane; Chromatography, High Pressure Liquid; Dopamine; Female; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Norepinephrine; Paroxetine; Piperidines; Saimiri; Serotonin; Serotonin Antagonists	1992
Regional distribution to recovery of 5-HT levels after administration of "atrophins" MDMA and D,L-fenfluramine. Stereospecificity and comparison with 5,7-dihydroxytryptamine. Annals of the New York Academy of Sciences, 1992, May-11, Volume: 648 Topics: 3,4-Dihydroxyphenylacetic Acid; 3,4-Methylenedioxyamphetamine; 5,7-Dihydroxytryptamine; Animals; Atrophy; Brain; Cerebral Ventricles; Designer Drugs; Dopamine; Fenfluramine; Homovanillic Acid; Hydroxyindoleacetic Acid; Injections, Intraventricular; Male; N-Methyl-3,4-methylenedioxyamphetamine; Norepinephrine; Organ Specificity; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism	1992
Methylenedioxymethamphetamine induces spontaneous tail-flicks in the rat via 5-HT1A receptors. European journal of pharmacology, 1991, Feb-07, Volume: 193, Issue:2 Topics: 3,4-Methylenedioxyamphetamine; Animals; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Reflex; Serotonin; Serotonin Antagonists; Tail	1991
Neuroanatomic specificity and time course of alterations in rat brain serotonergic pathways induced by MDMA (3,4-methylenedioxymethamphetamine): assessment using quantitative autoradiography. Synapse (New York, N.Y.), 1991, Volume: 8, Issue:4 Topics: 3,4-Methylenedioxyamphetamine; Animals; Autoradiography; Brain; Dopamine; Male; Mazindol; N-Methyl-3,4-methylenedioxyamphetamine; Neural Pathways; Norepinephrine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Reference Values; Serotonin; Time Factors	1991
Alterations in hippocampal function following repeated exposure to the amphetamine derivative methylenedioxymethamphetamine ("Ecstasy"). Psychopharmacology, 1991, Volume: 105, Issue:1 Topics: 3,4-Methylenedioxyamphetamine; Animals; Autoradiography; Brain Chemistry; Cerebral Cortex; Deoxyglucose; Glucose; Hippocampus; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists	1991
Reduction of in vivo binding of [3H]paroxetine in mouse brain by 3,4-methylenedioxymethamphetamine. Neuropharmacology, 1990, Volume: 29, Issue:7 Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Analysis of Variance; Animals; Brain; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Hydroxyindoleacetic Acid; Injections, Intravenous; Male; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists	1990
Effect of 3,4-methylenedioxymethamphetamine on [3H]paroxetine binding in the frontal cortex and blood platelets of rats. Biochemical pharmacology, 1991, Jan-01, Volume: 41, Issue:1 Topics: 3,4-Methylenedioxyamphetamine; Animals; Blood Platelets; Frontal Lobe; Hydroxyindoleacetic Acid; Ketanserin; Kinetics; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Time Factors; Tritium	1991
Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA). Journal of medicinal chemistry, 1990, Volume: 33, Issue:2 Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Behavior, Animal; Catecholamines; Cerebral Cortex; Hippocampus; Indans; Lysergic Acid Diethylamide; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Psychotropic Drugs; Rats; Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes	1990
5-hydroxytryptamine uptake blockers attenuate the 5-hydroxytryptamine-releasing effect of 3,4-methylenedioxymethamphetamine and related agents. European journal of pharmacology, 1990, Feb-20, Volume: 177, Issue:1-2 Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain Chemistry; In Vitro Techniques; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Synaptosomes	1990
Neurochemistry and neurotoxicity of substituted amphetamines. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1990, Volume: 3, Issue:3 Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Designer Drugs; Fenfluramine; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Endings; Paroxetine; Piperidines; Rats; Receptors, Serotonin; Serotonin	1990
Paroxetine as an in vivo indicator of 3,4-methylenedioxymethamphetamine neurotoxicity: a presynaptic serotonergic positron emission tomography ligand? Brain research, 1990, Sep-10, Volume: 527, Issue:1 Topics: 3,4-Methylenedioxyamphetamine; 5,7-Dihydroxytryptamine; Animals; Ligands; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Synapses; Tomography, Emission-Computed; Tritium	1990
3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:3 Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Brain Chemistry; Dopamine; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tritium	1987
Neurotoxic effects of the alpha-ethyl homologue of MDMA following subacute administration. Pharmacology, biochemistry, and behavior, 1989, Volume: 33, Issue:1 Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Biogenic Monoamines; Brain Chemistry; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nervous System Diseases; Norepinephrine; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Serotonin	1989
Reserpine does not prevent 3,4-methylenedioxymethamphetamine-induced neurotoxicity in the rat. Neuroscience letters, 1989, Sep-25, Volume: 104, Issue:1-2 Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Cerebral Cortex; Corpus Striatum; Designer Drugs; Dopamine; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Endings; Nervous System Diseases; Paroxetine; Piperidines; Rats; Rats, Inbred Strains; Reserpine; Serotonin	1989
Inhibition of MAO-B protects against MDMA-induced neurotoxicity in the striatum. Psychopharmacology, 1995, Volume: 118, Issue:3 Topics: Animals; Corpus Striatum; Hydroxyindoleacetic Acid; Male; Monoamine Oxidase Inhibitors; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Rats; Rats, Sprague-Dawley; Selegiline; Serotonin; Sodium Chloride	1995
The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype. British journal of pharmacology, 1995, Volume: 115, Issue:7 Topics: 3,4-Methylenedioxyamphetamine; Animals; Body Temperature Regulation; Brain; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Female; Fever; Humans; Hydroxyindoleacetic Acid; Male; Mixed Function Oxygenases; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Phenotype; Proadifen; Quinidine; Rats; Rectum; Serotonin; Serotonin Agents; Sex Factors; Tritium	1995
3,4-Methylenedioxymethamphetamine ('Ecstasy') promotes the translocation of protein kinase C (PKC): requirement of viable serotonin nerve terminals. Brain research, 1995, May-22, Volume: 680, Issue:1-2 Topics: Animals; Binding Sites; Biological Transport; Cerebral Cortex; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Nerve Endings; Paroxetine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Serotonin	1995
Serotonergic recovery after (+/-)3,4-(methylenedioxy) methamphetamine injury: observations in rats. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:3 Topics: 3,4-Methylenedioxyamphetamine; Animals; Axons; Brain Chemistry; Hydroxyindoleacetic Acid; Immunohistochemistry; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Paroxetine; Rats; Rats, Sprague-Dawley; Serotonin	1993
Chronic 3,4-methylenedioxymethamphetamine administration decreases glucocorticoid and mineralocorticoid receptor, but increases 5-hydroxytryptamine1C receptor gene expression in the rat hippocampus. Neuroscience, 1994, Volume: 61, Issue:1 Topics: Animals; Autoradiography; Corticosterone; Gene Expression; Hippocampus; In Situ Hybridization; Male; N-Methyl-3,4-methylenedioxyamphetamine; Organ Size; Paroxetine; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Receptors, Serotonin; RNA, Messenger	1994
Drug effects on distribution of [3H]3,4-methylenedioxymethamphetamine in mice. European journal of pharmacology, 1993, Apr-01, Volume: 228, Issue:5-6 Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Chromatography, High Pressure Liquid; Drug Interactions; Injections, Intravenous; Male; Mice; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Tissue Distribution	1993
Effect of acute monoamine depletion on 3,4-methylenedioxymethamphetamine-induced neurotoxicity. Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:3 Topics: 3,4-Methylenedioxyamphetamine; alpha-Methyltyrosine; Animals; Axons; Biogenic Monoamines; Brain Chemistry; Designer Drugs; Dialysis; Dopamine; Fenclonine; Male; Methyltyrosines; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Endings; Nervous System Diseases; Paroxetine; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Stereotaxic Techniques; Tyrosine 3-Monooxygenase	1993
The spin trap reagent alpha-phenyl-N-tert-butyl nitrone prevents 'ecstasy'-induced neurodegeneration of 5-hydroxytryptamine neurones. European journal of pharmacology, 1995, Jul-14, Volume: 280, Issue:3 Topics: Analysis of Variance; Animals; Binding, Competitive; Cerebral Cortex; Cyclic N-Oxides; Free Radicals; Hippocampus; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Neurons, Afferent; Nitrogen Oxides; Paroxetine; Rats; Serotonin; Serotonin Antagonists; Spin Labels	1995
Studies on the mechanism of p-chloroamphetamine neurotoxicity. Biochemical pharmacology, 1996, Oct-25, Volume: 52, Issue:8 Topics: Animals; Brain; Clorgyline; Dopamine; Fever; Hydroxyindoleacetic Acid; Indans; Male; Monoamine Oxidase Inhibitors; N-Methyl-3,4-methylenedioxyamphetamine; Neuroprotective Agents; Neurotoxins; p-Chloroamphetamine; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Selegiline; Serotonin; Serotonin Agents	1996
In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine. British journal of pharmacology, 1997, Volume: 121, Issue:5 Topics: Animals; Biogenic Monoamines; Body Temperature; Brain Chemistry; Fenfluramine; Free Radical Scavengers; Free Radicals; Hippocampus; Male; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; p-Chloroamphetamine; Paroxetine; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin Agents	1997
Panic disorder induced by large doses of 3,4-methylenedioxymethamphetamine resolved by paroxetine. Journal of clinical psychopharmacology, 1998, Volume: 18, Issue:1 Topics: Adult; Hallucinogens; Humans; Male; N-Methyl-3,4-methylenedioxyamphetamine; Panic Disorder; Paroxetine; Selective Serotonin Reuptake Inhibitors	1998
Role of hyperthermia in the protective action of clomethiazole against MDMA ('ecstasy')-induced neurodegeneration, comparison with the novel NMDA channel blocker AR-R15896AR. British journal of pharmacology, 1998, Volume: 124, Issue:3 Topics: Animals; Body Temperature; Brain Chemistry; Chlormethiazole; Excitatory Amino Acid Antagonists; Fever; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Neuroprotective Agents; Paroxetine; Pyridines; Rats; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors; Serotonin	1998
The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy'). Neuropharmacology, 1998, Volume: 37, Issue:7 Topics: Animals; Body Temperature; Brain; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; Drug Administration Schedule; Hippocampus; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Nerve Endings; Paroxetine; Rats; Rats, Inbred Strains; Serotonin; Serotonin Agents; Tissue Distribution	1998
Studies on the role of dopamine in the degeneration of 5-HT nerve endings in the brain of Dark Agouti rats following 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy') administration. British journal of pharmacology, 1999, Volume: 126, Issue:4 Topics: Animals; Body Temperature; Brain; Dopamine; Free Radicals; Haloperidol; Levodopa; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neurodegenerative Diseases; Paroxetine; Rats; Serotonin	1999
In vivo evidence against clomethiazole being neuroprotective against MDMA ('ecstasy')-induced degeneration of rat brain 5-HT nerve terminals by a free radical scavenging mechanism. Neuropharmacology, 1999, Volume: 38, Issue:2 Topics: Animals; Biotransformation; Body Temperature; Brain; Cerebral Cortex; Chlormethiazole; Corpus Striatum; Free Radical Scavengers; Gentisates; Hippocampus; Hydroxybenzoates; Hydroxyindoleacetic Acid; Kinetics; Male; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Nerve Endings; Neuroprotective Agents; Paroxetine; Rats; Salicylic Acid; Serotonin	1999
Studies on the neuroprotective effect of pentobarbitone on MDMA-induced neurodegeneration. Psychopharmacology, 1999, Volume: 142, Issue:4 Topics: Animals; Body Temperature; Brain; gamma-Aminobutyric Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neuroprotective Agents; Paroxetine; Pentobarbital; Rats	1999
The acute effect in rats of 3,4-methylenedioxyethamphetamine (MDEA, "eve") on body temperature and long term degeneration of 5-HT neurones in brain: a comparison with MDMA ("ecstasy"). Pharmacology & toxicology, 1999, Volume: 84, Issue:6 Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Animals; Brain; Cerebral Cortex; Dose-Response Relationship, Drug; Fever; Hippocampus; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Endings; Paroxetine; Rats; Serotonin; Time Factors; Visual Cortex	1999
Molecular cloning, expression and characterization of a bovine serotonin transporter. Brain research. Molecular brain research, 1999, Jul-23, Volume: 71, Issue:1 Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cattle; Citalopram; Cloning, Molecular; Desipramine; Female; Fluoxetine; HeLa Cells; Humans; Imipramine; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Organ Specificity; Paroxetine; Phylogeny; Pregnancy; Rats; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sequence Homology, Amino Acid; Serotonin; Serotonin Plasma Membrane Transport Proteins; Transfection	1999
Effects of "Ecstasy" blocked by serotonin reuptake inhibitors. The Journal of clinical psychiatry, 1999, Volume: 60, Issue:7 Topics: Adult; Citalopram; Female; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Selective Serotonin Reuptake Inhibitors; Substance-Related Disorders; Trichotillomania	1999
Alpha-lipoic acid prevents 3,4-methylenedioxy-methamphetamine (MDMA)-induced neurotoxicity. Neuroreport, 1999, Nov-26, Volume: 10, Issue:17 Topics: Animals; Antioxidants; Astrocytes; Binding Sites; Carrier Proteins; Fever; Frontal Lobe; Glial Fibrillary Acidic Protein; Hippocampus; Hypothermia; Male; Membrane Glycoproteins; Membrane Transport Proteins; N-Methyl-3,4-methylenedioxyamphetamine; Neostriatum; Nerve Tissue Proteins; Neuroprotective Agents; Paroxetine; Pyramidal Cells; Rats; Rats, Wistar; Serotonin; Serotonin Plasma Membrane Transport Proteins; Thioctic Acid	1999
Serotonergic deficits and impaired passive-avoidance learning in rats by MDEA: a comparison with MDMA. Pharmacology, biochemistry, and behavior, 2000, Volume: 65, Issue:2 Topics: 3,4-Methylenedioxyamphetamine; Animals; Avoidance Learning; Carrier Proteins; Designer Drugs; Frontal Lobe; Hippocampus; Male; Membrane Glycoproteins; Membrane Transport Proteins; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Paroxetine; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Serotonin Plasma Membrane Transport Proteins	2000
2-Deoxy-D-glucose prevents and nicotinamide potentiates 3, 4-methylenedioxymethamphetamine-induced serotonin neurotoxicity. Journal of neurochemistry, 2000, Volume: 75, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine Triphosphate; Animals; Body Temperature; Brain; Carrier Proteins; Corpus Striatum; Dopamine; Drug Synergism; Frontal Lobe; Hippocampus; Homovanillic Acid; Hydroxyindoleacetic Acid; Hypothermia; Male; Membrane Glycoproteins; Membrane Transport Proteins; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Neurotoxins; Niacinamide; Organ Specificity; Paroxetine; Rats; Rats, Wistar; Serotonin; Serotonin Plasma Membrane Transport Proteins	2000
3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-induced egr-1 mRNA in rat brain: pharmacological manipulation. European journal of pharmacology, 2000, Aug-25, Volume: 402, Issue:3 Topics: Animals; Benzazepines; Brain Chemistry; Dizocilpine Maleate; DNA-Binding Proteins; Dopamine Antagonists; Early Growth Response Protein 1; Excitatory Amino Acid Antagonists; Fluorobenzenes; Hallucinogens; Immediate-Early Proteins; Immunohistochemistry; In Situ Hybridization; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Phenols; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Transcription Factors	2000
Correlation between 5-HT content and uptake site density following (S)-MDMA and dexfenfluramine-induced depletion, and with neuroprotection by the glycine site-specific NMDA antagonist ACEA 1021. Annals of the New York Academy of Sciences, 2000, Volume: 914 Topics: Animals; Animals, Newborn; Brain; Brain Chemistry; Dexfenfluramine; Drug Interactions; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neuroprotective Agents; Paroxetine; Quinoxalines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; Tritium	2000
Methylenedioxymethamphetamine-induced suppression of interleukin-1beta and tumour necrosis factor-alpha is not mediated by serotonin. European journal of pharmacology, 2001, Apr-20, Volume: 418, Issue:1-2 Topics: Animals; Fenclonine; Frontal Lobe; Hypothalamus; Immunosuppression Therapy; Interleukin-1; Lipopolysaccharides; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Tumor Necrosis Factor-alpha	2001
Prior exposure to methylenedioxyamphetamine (MDA) induces serotonergic loss and changes in spontaneous exploratory and amphetamine-induced behaviors in rats. Life sciences, 2001, Feb-09, Volume: 68, Issue:12 Topics: Animals; Brain; Dextroamphetamine; Disease Models, Animal; Exploratory Behavior; Hallucinogens; Injections, Intraperitoneal; Male; Maze Learning; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Serotonin; Video Recording	2001
The mechanisms involved in the long-lasting neuroprotective effect of fluoxetine against MDMA ('ecstasy')-induced degeneration of 5-HT nerve endings in rat brain. British journal of pharmacology, 2001, Volume: 134, Issue:1 Topics: Animals; Binding, Competitive; Body Temperature; Brain; Cerebral Cortex; Fluoxetine; Fluvoxamine; Indoles; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Nerve Endings; Neuroprotective Agents; Paroxetine; Rats; Rectum; Serotonin; Serotonin Agents; Time Factors; Tritium	2001
Comparison of (+)-(11)C-McN5652 and (11)C-DASB as serotonin transporter radioligands under various experimental conditions. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2002, Volume: 43, Issue:5 Topics: Aniline Compounds; Animals; Carbon Radioisotopes; Carrier Proteins; Isoquinolines; Male; Membrane Glycoproteins; Membrane Transport Proteins; Models, Biological; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Papio; Paroxetine; Protein Binding; Radioligand Assay; Radiopharmaceuticals; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Sulfides; Tomography, Emission-Computed	2002
Protection against 3,4-methylenedioxymethamphetamine-induced neurodegeneration produced by glutathione depletion in rats is mediated by attenuation of hyperthermia. Journal of neurochemistry, 2002, Volume: 81, Issue:4 Topics: Animals; Brain; Brain Chemistry; Buthionine Sulfoximine; Drug Therapy, Combination; Fever; Glutathione; Hydroxyindoleacetic Acid; Liver; Male; Maleates; N-Methyl-3,4-methylenedioxyamphetamine; Neurodegenerative Diseases; Paroxetine; Rats; Rats, Inbred Strains; Serotonin; Treatment Outcome	2002
MDMA- and p-chlorophenylalanine-induced reduction in 5-HT concentrations: effects on serotonin transporter densities. European journal of pharmacology, 2002, Oct-25, Volume: 453, Issue:2-3 Topics: Animals; Autoradiography; Brain; Carrier Proteins; Cerebellar Cortex; Chromatography, High Pressure Liquid; Fenclonine; Hydroxyindoleacetic Acid; Male; Membrane Glycoproteins; Membrane Transport Proteins; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Paroxetine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins	2002
Functional consequences of perinatal exposure to 3,4-methylenedioxymethamphetamine in rat brain. British journal of pharmacology, 2002, Volume: 137, Issue:7 Topics: Adrenergic Uptake Inhibitors; Animals; Animals, Newborn; Binding, Competitive; Brain; Female; Glucose; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Serotonin; Time Factors; Tritium	2002
Reduced social interaction following 3,4-methylenedioxymethamphetamine is not associated with enhanced 5-HT 2C receptor responsivity. Neuropharmacology, 2003, Volume: 44, Issue:4 Topics: Animals; Brain; Corticosterone; Exploratory Behavior; Hydroxyindoleacetic Acid; Hypothermia; In Vitro Techniques; Male; Maze Learning; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Piperazines; Radioligand Assay; Rats; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin; Serotonin Agents; Serotonin Receptor Agonists; Social Behavior; Substance Withdrawal Syndrome	2003
The effects of MDMA pretreatment on the behavioural effects of other drugs of abuse in the rat elevated plus-maze test. Pharmacology, biochemistry, and behavior, 2004, Volume: 77, Issue:4 Topics: Animals; Anxiety; Drug Interactions; Hippocampus; Illicit Drugs; Male; Maze Learning; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Protein Binding; Rats	2004
Acute and long-term effects of a single dose of MDMA on aggression in Dark Agouti rats. The international journal of neuropsychopharmacology, 2006, Volume: 9, Issue:1 Topics: Adrenergic Uptake Inhibitors; Aggression; Animals; Brain; Glucose; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Pyridines; Quinoxalines; Rats; Receptors, Serotonin, 5-HT1; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Time Factors	2006
Partial lesion of the serotonergic system by a single dose of MDMA results in behavioural disinhibition and enhances acute MDMA-induced social behaviour on the social interaction test. Neuropharmacology, 2006, Volume: 50, Issue:7 Topics: Animals; Anxiety; Behavior, Animal; Brain; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Rats; Serotonin Agents; Social Behavior	2006
MDMA-induced neurotoxicity: long-term effects on 5-HT biosynthesis and the influence of ambient temperature. British journal of pharmacology, 2006, Volume: 148, Issue:6 Topics: Animals; Body Temperature; Brain; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Rats; Serotonin; Temperature; Tryptophan Hydroxylase	2006
Repeated administration of the substituted amphetamine p-methoxyamphetamine produces reductions in cortical 5-HT transporter binding but not 5-HT content, unlike 3,4-methylenedioxyamethamphetamine. European journal of pharmacology, 2006, Sep-28, Volume: 546, Issue:1-3 Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamines; Animals; Binding, Competitive; Brain Chemistry; Cerebral Cortex; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Electrochemistry; Hallucinogens; Hydroxyindoleacetic Acid; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptic Transmission; Time Factors	2006
MDMA self-administration in rats: acquisition, progressive ratio responding and serotonin transporter binding. The European journal of neuroscience, 2007, Volume: 26, Issue:11 Topics: Animals; Autoradiography; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Protein Binding; Rats; Rats, Sprague-Dawley; Self Administration; Serotonin Agents; Serotonin Plasma Membrane Transport Proteins; Tritium	2007
Reduced efficacy of fluoxetine following MDMA ("Ecstasy")-induced serotonin loss in rats. Progress in neuro-psychopharmacology & biological psychiatry, 2008, Dec-12, Volume: 32, Issue:8 Topics: Animals; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Drug Interactions; Fluoxetine; Hallucinogens; Immobility Response, Tonic; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Swimming; Time Factors; Tritium	2008
Inhibitory effect of selective serotonin reuptake inhibitors on the vesicular monoamine transporter 2. Neuroscience letters, 2009, May-01, Volume: 454, Issue:3 Topics: Animals; Dopamine; Fluoxetine; Fluvoxamine; Haloperidol; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Rats; Rats, Wistar; Reserpine; Selective Serotonin Reuptake Inhibitors; Synaptic Vesicles; Vesicular Monoamine Transport Proteins	2009
A study on the mechanisms by which minocycline protects against MDMA ('ecstasy')-induced neurotoxicity of 5-HT cortical neurons. Neurotoxicity research, 2010, Volume: 18, Issue:2 Topics: Animals; Drug Administration Schedule; Fever; Frontal Lobe; Hypothalamus; Inflammation; Interleukin-1beta; Male; Microglia; Minocycline; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; NF-kappa B; Paroxetine; Radioligand Assay; Rats; Rats, Inbred Strains; Serotonin; Serotonin Plasma Membrane Transport Proteins	2010
Acute tryptophan depletion potentiates 3,4-methylenedioxymethamphetamine-induced cerebrovascular hyperperfusion in adult male Wistar rats. Journal of neuroscience research, 2010, May-15, Volume: 88, Issue:7 Topics: Animals; Binding, Competitive; Brain; Cerebral Arteries; Cerebrovascular Circulation; Cerebrovascular Disorders; Depressive Disorder; Disease Models, Animal; Hyperemia; Male; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Rats; Rats, Wistar; Serotonin; Serotonin Agents; Serotonin Plasma Membrane Transport Proteins; Tryptophan; Vasodilation	2010
Evidence that MDMA ('ecstasy') increases cannabinoid CB2 receptor expression in microglial cells: role in the neuroinflammatory response in rat brain. Journal of neurochemistry, 2010, Volume: 113, Issue:1 Topics: Analysis of Variance; Animals; Brain; CD11b Antigen; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hallucinogens; In Vitro Techniques; Indoles; Interleukin-1beta; Male; Microglia; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Peptide Fragments; Rats; Receptor, Cannabinoid, CB2; Selective Serotonin Reuptake Inhibitors; Serotonin; Time Factors; Tritium	2010
Deaths involving serotonergic drugs. Forensic science international, 2010, May-20, Volume: 198, Issue:1-3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Australia; Cause of Death; Citalopram; Cyclohexanols; Female; Fluoxetine; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Serotonin Agents; Sertraline; Tramadol; Venlafaxine Hydrochloride	2010
Elevated BDNF protein level in cortex but not in hippocampus of MDMA-treated Dark Agouti rats: a potential link to the long-term recovery of serotonergic axons. Neuroscience letters, 2010, Jul-05, Volume: 478, Issue:2 Topics: Animals; Axons; Brain-Derived Neurotrophic Factor; Hippocampus; Illicit Drugs; Male; N-Methyl-3,4-methylenedioxyamphetamine; Parietal Lobe; Paroxetine; Protein Binding; Radioligand Assay; Rats; Serotonin; Time Factors; Tryptophan Hydroxylase	2010
Comparative neurochemical profile of 3,4-methylenedioxymethamphetamine and its metabolite alpha-methyldopamine on key targets of MDMA neurotoxicity. Neurochemistry international, 2011, Volume: 58, Issue:1 Topics: Animals; Cell Membrane; Cell Survival; Cocaine; Deoxyepinephrine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; In Vitro Techniques; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Paroxetine; PC12 Cells; Protein Conformation; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptosomes	2011
Molecular analysis and modeling of inactivation of human CYP2D6 by four mechanism based inactivators. Drug metabolism letters, 2012, Volume: 6, Issue:1 Topics: Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Enzyme Inhibitors; Humans; Imidazoles; Ligands; Models, Molecular; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Pyridines; Pyrimidines	2012
3,4-Methylenedioxy-methamphetamine induces in vivo regional up-regulation of central nicotinic receptors in rats and potentiates the regulatory effects of nicotine on these receptors. Neurotoxicology, 2013, Volume: 35 Topics: Aconitine; Animals; Blotting, Western; Brain; Bridged Bicyclo Compounds, Heterocyclic; Drug Administration Schedule; Drug Synergism; Immunoprecipitation; Injections, Subcutaneous; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nicotine; Nicotinic Agonists; Paroxetine; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin Plasma Membrane Transport Proteins; Time Factors; Up-Regulation	2013
Protracted treatment with MDMA induces heteromeric nicotinic receptor up-regulation in the rat brain: an autoradiography study. Progress in neuro-psychopharmacology & biological psychiatry, 2014, Aug-04, Volume: 53 Topics: Animals; Autoradiography; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Drug Interactions; Hallucinogens; Iodine Radioisotopes; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nicotinic Agonists; Paroxetine; Protein Binding; Pyridines; Radiography; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Selective Serotonin Reuptake Inhibitors; Tritium; Up-Regulation	2014