Compounds > n-methyl-3,4-methylenedioxyamphetamine

n-methyl-3,4-methylenedioxyamphetamine and acetylcysteine

n-methyl-3,4-methylenedioxyamphetamine has been researched along with acetylcysteine in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (46.67)29.6817
2010's8 (53.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bai, F; Lau, SS; Miller, RT; Monks, TJ1
Ansorena, E; Cenarruzabeitia, E; Iraburu, MJ; López-Zabalza, MJ; Montiel-Duarte, C1
Bastos, ML; Borges, F; Carvalho, F; Carvalho, M; Fernandes, E; Milhazes, N; Remião, F1
de la Torre, R; Duvauchelle, C; Ikegami, A; Jones, DC; Lau, SS; Monks, TJ; Olsen, CM1
Abreu, AR; Bastos, ML; Branco, PS; Capela, JP; Carvalho, F; Ferreira, LM; Lobo, AM; Meisel, A; Remião, F1
Bastos, ML; Branco, PS; Capela, JP; Carvalho, F; Dirnagl, U; Fernandes, E; Ferreira, LM; Lobo, AM; Macedo, C; Meisel, A; Remião, F1
Carvalho, F; Lucchesi, PA; Shenouda, SK; Varner, KJ1
Largeron, M; Martinez, CM; McCann, U; Mechan, A; Mueller, M; Neudörffer, A; Ricaurte, GA1
Bastos, ML; Branco, PS; Capela, JP; Carvalho, F; Costa, VM; Fernandes, E; Ferreira, LM; Ferreira, PS; Meisel, A; Nogueira, TB1
Mehdizadeh, M; Mousavizadeh, K; Mousavizedeh, K; Pourheydar, B; Rahbar, E; Soleimani Asl, S; Soleimani, M1
Barbosa, DJ; Bastos, Mde L; Branco, PS; Capela, JP; Carvalho, F; Fernandes, E; Ferreira, LM; Silva, R; Vilas-Boas, V1
Barbosa, DJ; Bastos, ML; Branco, PS; Capela, JP; Carvalho, F; Fernandes, E; Ferreira, LM; Silva, R1
Mehdizadeh, M; Saifi, B; Sakhaie, A; Soleimani Asl, S; Zargooshnia, S1
Canale, D; de Bragança, AC; de Brito, T; de Jesus, DA; Gois, PH; Magaldi, AJ; Moreau, RLM; Seguro, AC; Shimizu, MHM; Silva, AMG1
Inomata, A; Nakagawa, Y; Suzuki, T1

Reviews

1 review(s) available for n-methyl-3,4-methylenedioxyamphetamine and acetylcysteine

ArticleYear
Serotonergic neurotoxicity of methylenedioxyamphetamine and methylenedioxymetamphetamine.
    Advances in experimental medicine and biology, 2001, Volume: 500

    Topics: 3,4-Methylenedioxyamphetamine; Acetylcysteine; Animals; Behavior, Animal; Brain; Deoxyepinephrine; Glutathione; Hallucinogens; Humans; Molecular Structure; N-Methyl-3,4-methylenedioxyamphetamine; Neurotransmitter Agents; Rats; Serotonin Agents

2001

Other Studies

14 other study(ies) available for n-methyl-3,4-methylenedioxyamphetamine and acetylcysteine

ArticleYear
Role of reactive oxygen species, glutathione and NF-kappaB in apoptosis induced by 3,4-methylenedioxymethamphetamine ("Ecstasy") on hepatic stellate cells.
    Biochemical pharmacology, 2004, Mar-15, Volume: 67, Issue:6

    Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Cells, Cultured; Drug Interactions; Glutathione; Hepatocytes; N-Methyl-3,4-methylenedioxyamphetamine; NF-kappa B; Oxidative Stress; Quinine; Rats; Reactive Oxygen Species; Stellate Ganglion; Vitamin K 3

2004
The toxicity of N-methyl-alpha-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine.
    Toxicology, 2004, Aug-05, Volume: 200, Issue:2-3

    Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Antioxidants; Ascorbic Acid; Cell Separation; Cell Survival; Chromatography, High Pressure Liquid; Deoxyepinephrine; Free Radical Scavengers; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Hallucinogens; Hepatocytes; In Vitro Techniques; Male; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Spectrophotometry, Ultraviolet

2004
Serotonergic neurotoxic metabolites of ecstasy identified in rat brain.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:1

    Topics: Acetylcysteine; Animals; Biotransformation; Brain; Calibration; Chromatography, High Pressure Liquid; Electrodes, Implanted; Glutathione; Hypothermia; Injections, Subcutaneous; Male; Mass Spectrometry; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxins; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents

2005
Neurotoxicity of Ecstasy metabolites in rat cortical neurons, and influence of hyperthermia.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:1

    Topics: Acetylcysteine; Acridine Orange; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Drug Synergism; Ethidium; Fever; Fluorescent Dyes; Hallucinogens; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Rats; Rats, Wistar

2006
Neurotoxicity mechanisms of thioether ecstasy metabolites.
    Neuroscience, 2007, Jun-08, Volume: 146, Issue:4

    Topics: 3,4-Methylenedioxyamphetamine; Acetylcysteine; Adenosine Triphosphate; Animals; Caspase 3; Cell Death; Cells, Cultured; Cerebral Cortex; Deoxyepinephrine; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Free Radical Scavengers; Glutathione; Hallucinogens; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Rats; Rats, Wistar; Temperature; Time Factors

2007
Metabolites of MDMA induce oxidative stress and contractile dysfunction in adult rat left ventricular myocytes.
    Cardiovascular toxicology, 2009, Volume: 9, Issue:1

    Topics: Acetylcysteine; Animals; Antioxidants; Calcium Signaling; Cells, Cultured; Deoxyepinephrine; Dose-Response Relationship, Drug; Glutathione; Heart Ventricles; Male; Myocardial Contraction; Myocytes, Cardiac; N-Methyl-3,4-methylenedioxyamphetamine; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Time Factors

2009
Synthesis and neurotoxicity profile of 2,4,5-trihydroxymethamphetamine and its 6-(N-acetylcystein-S-yl) conjugate.
    Chemical research in toxicology, 2011, Jun-20, Volume: 24, Issue:6

    Topics: Acetylcysteine; Adrenergic Uptake Inhibitors; Animals; Brain; Hydroxyindoleacetic Acid; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Neurotoxins; Rats; Rats, Sprague-Dawley; Serotonin

2011
Neurotoxicity of "ecstasy" and its metabolites in human dopaminergic differentiated SH-SY5Y cells.
    Toxicology letters, 2013, Feb-04, Volume: 216, Issue:2-3

    Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Buthionine Sulfoximine; Cell Death; Cell Differentiation; Cell Line, Tumor; Dipeptides; Dopaminergic Neurons; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Piperazines

2013
Protective effects of N-acetylcysteine on 3, 4-methylenedioxymethamphetamine-induced neurotoxicity in male Sprague-Dawley rats.
    Metabolic brain disease, 2013, Volume: 28, Issue:4

    Topics: Acetylcysteine; Animals; bcl-2-Associated X Protein; Caspase 3; Cell Death; Down-Regulation; Hippocampus; Male; Maze Learning; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley

2013
The mixture of "ecstasy" and its metabolites is toxic to human SH-SY5Y differentiated cells at in vivo relevant concentrations.
    Archives of toxicology, 2014, Volume: 88, Issue:2

    Topics: Acetylcysteine; Calcium; Caspase 3; Cell Differentiation; Cell Line; Deoxyepinephrine; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Glutathione; Humans; Mitochondria; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Neurotoxicity Syndromes; Reactive Oxygen Species

2014
"Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites.
    Archives of toxicology, 2014, Volume: 88, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Acetylcysteine; Caspase 3; Cell Death; Cell Differentiation; Cell Line; Deoxyepinephrine; Fever; Glutathione; Humans; Mitochondria; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Neurotoxicity Syndromes; Temperature

2014
Attenuation of ecstasy-induced neurotoxicity by N-acetylcysteine.
    Metabolic brain disease, 2015, Volume: 30, Issue:1

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; CA1 Region, Hippocampal; Drug Evaluation, Preclinical; Learning Disabilities; Male; Maze Learning; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Spatial Memory

2015
Ecstasy induces reactive oxygen species, kidney water absorption and rhabdomyolysis in normal rats. Effect of N-acetylcysteine and Allopurinol in oxidative stress and muscle fiber damage.
    PloS one, 2017, Volume: 12, Issue:7

    Topics: Acetylcysteine; Allopurinol; Animals; Aquaporin 2; Blotting, Western; Epithelial Sodium Channels; Free Radical Scavengers; Glutathione; Hallucinogens; Kidney; Kidney Tubules, Collecting; Male; Muscle Fibers, Skeletal; N-Methyl-3,4-methylenedioxyamphetamine; Oxidative Stress; Rats, Wistar; Reactive Oxygen Species; Rhabdomyolysis; Solute Carrier Family 12, Member 1; Thiobarbituric Acid Reactive Substances; Water

2017
Preventive effects of fructose and N-acetyl-L-cysteine against cytotoxicity induced by the psychoactive compounds N-methyl-5-(2-aminopropyl)benzofuran and 3,4-methylenedioxy-N-methamphetamine in isolated rat hepatocytes.
    Journal of applied toxicology : JAT, 2018, Volume: 38, Issue:2

    Topics: Acetylcysteine; Animals; Benzofurans; Cell Survival; Cells, Cultured; Energy Metabolism; Fructose; Hepatocytes; Male; Membrane Potential, Mitochondrial; N-Methyl-3,4-methylenedioxyamphetamine; Oxidative Stress; Propylamines; Psychotropic Drugs; Rats, Inbred F344

2018