Page last updated: 2024-09-03

n-hydroxythalidomide and thalidomide

n-hydroxythalidomide has been researched along with thalidomide in 8 studies

Compound Research Comparison

Studies
(n-hydroxythalidomide)
Trials
(n-hydroxythalidomide)
Recent Studies (post-2010)
(n-hydroxythalidomide)
Studies
(thalidomide)
Trials
(thalidomide)
Recent Studies (post-2010) (thalidomide)
8029,7891,3854,342

Protein Interaction Comparison

ProteinTaxonomyn-hydroxythalidomide (IC50)thalidomide (IC50)
Cereblon isoform 4Magnetospirillum gryphiswaldense7.8
Prostaglandin G/H synthase 1Ovis aries (sheep)0.37
Prostaglandin G/H synthase 2Ovis aries (sheep)0.5
DNA damage-binding protein 1Homo sapiens (human)1.38
Protein cereblonHomo sapiens (human)1.38

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's2 (25.00)18.2507
2000's3 (37.50)29.6817
2010's1 (12.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Hashimoto, Y; Katayama, R; Miyachi, H; Naito, M; Noguchi, T1
Hashimoto, Y; Makishima, M; Miyachi, H; Nakagawa, A; Uno, S1
Blaschke, G; Hess, HR; Lüpke, NP1
Chuong, PH; Claude, JR; Galons, H; Huynh-Thien, D; Righenzi, S; Voisin, J; Warnet, JM; Zhu, J1
Blaschke, G; Chankvetadze, B; Meyring, M2
Baran, PS; Che, G; Eastgate, MD; Edwards, JT; Liu, Z; Malins, LR; Merchant, RR; Qin, T; Shaw, SA; Shen, Z; Smith, JM1
Fu, H; Gao, H; Huang, J; Lan, H; McGinty, S; Wang, G; Wang, Y; Wang, Z; Yin, T; Zhang, X1

Other Studies

8 other study(ies) available for n-hydroxythalidomide and thalidomide

ArticleYear
Cell differentiation inducers derived from thalidomide.
    Bioorganic & medicinal chemistry letters, 2005, Jul-01, Volume: 15, Issue:13

    Topics: Antineoplastic Agents; Cell Differentiation; Drug Screening Assays, Antitumor; Flow Cytometry; HL-60 Cells; Humans; Indoles; Isoindoles; Leukemia; Lipopolysaccharide Receptors; Structure-Activity Relationship; Thalidomide

2005
Progesterone receptor antagonists with a 3-phenylquinazoline-2,4-dione/2-phenylisoquinoline-1,3-dione skeleton.
    Bioorganic & medicinal chemistry, 2008, Jul-15, Volume: 16, Issue:14

    Topics: Alkaline Phosphatase; Animals; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Genes, Reporter; Humans; Inhibitory Concentration 50; Quinazolines; Quinolines; Receptors, Progesterone; Structure-Activity Relationship

2008
[Synthesis and teratogenic action of n-hydroxythalidomide].
    Arzneimittel-Forschung, 1989, Volume: 39, Issue:3

    Topics: Animals; Chemical Phenomena; Chemistry; Chick Embryo; Teratogens; Thalidomide

1989
In vitro and in vivo immunosuppressive potential of thalidomide and its derivative, N-hydroxythalidomide, alone and in combination with cyclosporin A.
    International journal of immunopharmacology, 1997, Volume: 19, Issue:5

    Topics: Animals; Cyclosporine; Drug Interactions; Drug Therapy, Combination; Graft vs Host Reaction; Immunosuppressive Agents; Lymphocyte Activation; Mice; T-Lymphocytes; Thalidomide

1997
Enantioseparation of thalidomide and its hydroxylated metabolites using capillary electrophoresis with various cyclodextrins and their combinations as chiral buffer additives.
    Electrophoresis, 1999, Volume: 20, Issue:12

    Topics: Acrylic Resins; Buffers; Cyclodextrins; Electrophoresis, Capillary; Humans; Molecular Structure; Silicon Dioxide; Thalidomide

1999
Simultaneous separation and enantioseparation of thalidomide and its hydroxylated metabolites using high-performance liquid chromatography in common-size columns, capillary liquid chromatography and nonaqueous capillary electrochromatography.
    Journal of chromatography. A, 2000, Apr-21, Volume: 876, Issue:1-2

    Topics: Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Hydroxylation; Stereoisomerism; Thalidomide

2000
Decarboxylative Alkynylation.
    Angewandte Chemie (International ed. in English), 2017, 09-18, Volume: 56, Issue:39

    Topics: Alkynes; Decarboxylation; Esters; Molecular Structure; Nickel; Phthalimides; Thalidomide

2017
Covalent immobilization of biomolecules on stent materials through mussel adhesive protein coating to form biofunctional films.
    Materials science & engineering. C, Materials for biological applications, 2020, Volume: 106

    Topics: Carbodiimides; Cell Proliferation; Cell Survival; Coated Materials, Biocompatible; Dimethylamines; Endothelial Cells; Humans; Microscopy, Electron, Scanning; Proteins; Stents; Thalidomide

2020