n-formylmethionine leucyl-phenylalanine has been researched along with muramidase in 146 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 87 (59.59) | 18.7374 |
| 1990's | 44 (30.14) | 18.2507 |
| 2000's | 14 (9.59) | 29.6817 |
| 2010's | 1 (0.68) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goodman, EB; Tenner, AJ | 1 |
| Inazu, T; Nakagawara, G; Ohta, S; Taniguchi, T; Yamamura, H | 1 |
| Gavuzzo, E; Giuliani, AL; Lucente, G; Mazza, F; Pagani Zecchini, G; Paglialunga Paradisi, M; Pochetti, G; Spisani, S; Torrini, I; Traniello, S | 1 |
| Bajaj, MS; Hyers, TM; Kew, RR; Webster, RO | 1 |
| Filep, JG; Földes-Filep, E | 1 |
| Glovsky, MM; Kebo, DK; Kunkel, S; Nagata, S | 1 |
| Hamdan, HF; Luikart, SD | 1 |
| Kwan-Yeung, L; Turkson, J; Wong, K | 1 |
| Cerletti, C; de Gaetano, G; Evangelista, V; Rajtar, G; White, JG | 1 |
| Jacobson, DP; O'Flaherty, JT; Redman, JF; Rossi, AG | 2 |
| Grünbaum, L; Seifert, R; Wenzel-Seifert, K | 1 |
| Burkey, TH; Farmer, JC; Kew, RR; Webster, RO | 1 |
| Kwan-Yeung, L; Ng, D; Wong, K | 1 |
| Bazzoni, G; Dejana, E; Del Maschio, A | 1 |
| Cockcroft, S | 1 |
| Lelkes, PI; Yuli, I | 1 |
| Naps, MS; Rubin, RP; Thompson, RH | 1 |
| Graeff, RW; Hunt, TK; Mathes, SJ; Paty, PB | 1 |
| Austinhirst, R; Snyder, F; Vallari, DS | 1 |
| Bessler, WG; Hauschildt, S; Jung, G; Metzger, J; Richter-Freund, M; Schultz, G; Seifert, R; Wiesmüller, KH | 1 |
| Abramson, SB; Callegari, PE; Haines, KA; Philips, MR; Reibman, J; Weissmann, G | 1 |
| Kraus, JL; Lederer, F; Ravel, P | 1 |
| Gabler, WL | 1 |
| Beatty, PG; Gahmberg, CG; Patarroyo, M; Serhan, CN | 1 |
| Conroy, MC; Hoffman, MD; Thueson, DO; Wright, CD | 1 |
| Paul, E; Redl, H; Schiesser, A; Schlag, G; Wilfing, C | 1 |
| Gyllenhammar, H; Hafström, I; Palmblad, J; Ringertz, B | 1 |
| Deierkauf, M; Elferink, JG | 4 |
| Bullock, WW; Creamer, HR; Gabler, WL | 1 |
| Hoff, SF; Shelly, J | 1 |
| King, CH; Kusner, DJ | 1 |
| Kalunta, CI; Kaptein, JS; Lad, PM; Lee, GH; Niedzin, H; Scott, SJ | 1 |
| Maki, Y; Makino, H; Saijo, T | 1 |
| Belleau, B; di Paola, A; Lajoie, G; Rao, VS; Sauve, G | 1 |
| Gerard, C; McCall, C; Salzer, W | 1 |
| Blake, MS; Cristello, P; Haines, KA; Korchak, H; Weissmann, G; Yeh, L | 1 |
| Lacal, P; Mollinedo, F; Pulido, R; Sánchez-Madrid, F | 1 |
| Haines, KA; Korchak, HM; Lundquist, KF; Vosshall, LB; Weissmann, G; Wilkenfeld, C | 1 |
| Akabane, T; Hasui, M; Kobayashi, Y; Komiyama, A; Masuda, M; Matsuoka, T; Murata, K; Yamazaki, M; Yasui, K | 1 |
| Di Perri, T; Pasini, FL | 1 |
| Browder, B; Feister, AJ; Mohanakumar, T; Ruddy, S; Willis, HE | 1 |
| Brodt, JK; Cotta, LA; Hurst, JM; Solomkin, JS | 1 |
| Borgeat, P; Molski, TF; Naccache, PH; Sha'afi, RI; White, JR | 1 |
| Garrido, M; Muniain, MA; Pérez-Venegas, JJ; Pozuelo, F; Rodríguez-Hornillo, MC; Romero-Tabares, A | 1 |
| Lindgren, JA; Palmblad, J; Ringertz, B | 1 |
| Anderson, R; Fernandes, AC; Ras, GJ | 1 |
| Hoult, JR; Nourshargh, S | 2 |
| Asaoka, K; Fujikura, T; Suzuki, K; Takahashi, K | 1 |
| Imre, KM; Schrier, DJ | 1 |
| Bureau, M; Joseph, D; Vargaftig, BB | 1 |
| Neal, TM; Vissers, MC; Winterbourn, CC | 1 |
| Baehner, RL; Boxer, LA; Ingraham, LM; Lafuze, JE | 1 |
| Coëffier, E; Joseph, D; Prévost, MC; Vargaftig, BB | 1 |
| Elferink, JG | 1 |
| Smolen, JE; Stoehr, SJ | 1 |
| Bignold, LP; Ferrante, A | 1 |
| Glinski, W; Jablonska, S; Janczura, E; Tigalonowa, M | 1 |
| Kraus, JL | 1 |
| Chamberland, S; Groenewoud, Y; Hart, DA | 1 |
| Becker, EL; Bonora, GM; Freer, RJ; Toniolo, C | 1 |
| Cavalletti, T; Gavioli, R; Scatturin, A; Spisani, S; Traniello, S; Vertuani, G | 1 |
| Jacob, HS; Weisdorf, DJ | 1 |
| Botta, GA; Buffa, D; Buffa, P; Buzzi, E; de Graaff, J; Eftimiadi, C; Tonetti, M; van Steenbergen, MT | 1 |
| Capecchi, PL; Ceccatelli, L; Di Perri, T; Laghi Pasini, F; Orrico, A; Pasqui, AL | 1 |
| Balaram, P; Becker, EL; Raj, PA; Sukumar, M | 1 |
| Smith, RJ; Speziale, SC | 1 |
| Fraioli, F; Gnessi, L; Pert, CB; Ruff, MR | 1 |
| Johnson, KJ; Sulavik, MC; Ward, PA | 1 |
| Coates, TD; Torres, M | 1 |
| Abramson, S; Edelson, H; Kaplan, H; Ludewig, R; Weissmann, G | 1 |
| Blandina, P; Brunelleschi, S; Fantozzi, R; Mannaioni, PF; Masini, E; Raimondi, L; Soldaini, GB | 1 |
| Blandina, P; Brunelleschi, S; Cambi, S; Fantozzi, R; Mannaioni, PF; Masini, E | 1 |
| Fletcher, MP; Gallin, JI; Seligmann, BE | 1 |
| Baehner, RL; Boxer, LA; Yasaka, T | 1 |
| Edelson, HS; Kaplan, HB; Korchak, HM; Smolen, JE; Weissmann, G | 1 |
| Smolen, JE; Weissmann, G | 1 |
| Baehner, RL; Boxer, LA; Coates, TD; DeBoard, JE; Wolach, B | 1 |
| Becker, EL; Makryannis, A; Naccache, PH; Sha'afi, RI; Volpi, M | 1 |
| Bowman, BJ; Iden, SS; McGuire, JC; Smith, HW; Smith, RJ; Sun, FF | 1 |
| Guindon, Y; Lau, CK; Rokach, J; Rollins, TE; Springer, MS; Zamboni, R; Zanolari, B | 1 |
| Fantone, JC; Freer, RJ; Marasco, WA; Ward, PA | 1 |
| Synderman, R; Tomonaga, A; Yuli, I | 1 |
| Ceccatelli, L; Di Perri, T; Laghi-Pasini, F; Pasqui, AL | 1 |
| Baehner, RL; Boxer, LA; Coates, TD; Higgins, C; Tzeng, DY; Wolach, B | 1 |
| Baehner, RL; Berkow, RL; Tzeng, DY; Williams, LV | 1 |
| Becker, EL; Mackin, WM | 1 |
| Flick, MR; Goldstein, IM; Webster, RO | 1 |
| Campbell, EJ; Griffin, GL; McCusker, KT; Senior, RM; Totti, N | 1 |
| Aviram, I; Babior, BM; Simons, ER | 1 |
| Atkinson, J; Mehta, J; Muniain, MA; Simchowitz, L; Spilberg, I | 1 |
| Ceccatelli, L; Di Perri, T; Laghi Pasini, F; Pasqui, AL | 1 |
| Brodt, JK; Cotta, LA; Hurst, JW; Ogle, CK; Solomkin, JS | 1 |
| Buyon, JP; Ganguly, M; Korchak, HM; Rutherford, LE; Weissmann, G | 1 |
| Carroll, C; Hammett, MJ; McCall, CE; O'Flaherty, JT; Thomas, MJ; Wykle, RL | 1 |
| Fujikura, T; Kobayashi, M; Sakatani, T; Sasagawa, S; Suzuki, K; Swenson, C; Watanabe, M | 1 |
| McCall, CE; O'Flaherty, JT; Schmitt, JD; Wykle, RL | 1 |
| Belleau, B; DiPaola, A; Kraus, JL | 1 |
| Freed, R; Noble, P; Smolen, JE; Weissmann, G | 1 |
| Balaram, P; Becker, EL; Freer, RJ; Iqbal, M; Showell, HJ | 1 |
| Bowman, BJ; Iden, SS; McGuire, JC; Smith, RJ; Sprecher, H; Sun, FF | 1 |
| Glovsky, MM; Showell, HJ; Ward, PA | 1 |
| Ackerman, SK; Douglas, SD; Matter, L | 1 |
| Allen, J; Baehner, RL; Boxer, LA; Oseas, RS; Yang, HH | 1 |
| Friedman, RS; Hoffstein, ST; Weissmann, G | 1 |
| Aswanikumar, S; Becker, EL; Day, AR; Freer, RJ; Radding, JA; Schiffmann, E; Showell, HJ | 1 |
| Fischer, DG; Koren, HS; Pike, MC; Snyderman, R | 1 |
| Bayssas, M; Blaise, D; Fossat, C; Juhan-Vague, I; Maraninchi, D; Sainty, D; Stoppa, AM; Viens, P; Yver, A | 1 |
| Aiken, ML; Painter, RG | 1 |
| Dikshit, M; Kumari, R; Seth, P; Srimal, RC | 1 |
| Abdelghaffar, H; Labro, MT; Mtairag, EM | 1 |
| Schächtele, C; Seifert, R; Wenzel-Seifert, K | 1 |
| Ando, M; Furui, H; Hirano, T; Miyamoto, K; Suzuki, K; Takagi, K | 1 |
| Beermann, U; Capecchi, PL; Ceccatelli, L; Di Perri, T; Laghi Pasini, F | 1 |
| Jones, CJ; MacIntyre, DE; McMillan, RM; Rossi, AG | 1 |
| Anderson, DC; Brown, EJ; Graham, IL; Lefkowith, JB | 1 |
| Bellavite, P; Chirumbolo, S; Guzzo, P; Lippi, G; Santonastaso, C | 1 |
| Krautwurst, D; Lentzen, H; Seifert, R; Wenzel-Seifert, K | 1 |
| Aktories, K; Lentzen, H; Seifert, R; Wenzel-Seifert, K | 1 |
| Butler, J; Downey, GP; Fialkow, L; Grinstein, S; Schelm, JA; Sue-A-Quan, AK; Vlahos, CJ | 1 |
| Bolotin, A; Naor, R; Rosen, G; Sela, MN; Weinberg, A | 1 |
| Capodici, C; Feoktistov, M; Hanft, S; Pillinger, MH | 1 |
| Aviram, I; Irit, A; Michaela, S; Sharabani, M; Tal, T | 1 |
| Dalpiaz, A; Fabbri, E; Ferretti, ME; Pecoraro, R; Scatturin, A; Spisani, S; Traniello, S | 1 |
| Bai, J; Cheng, G; Wang, W; Zhu, X | 1 |
| Cavicchioni, G; Niccoli, S; Rizzuti, O; Spisani, S; Varani, K | 1 |
| Han, ES; Jang, YY; Lee, CS | 1 |
| Cavicchioni, G; Spisani, S | 1 |
| Dalpiaz, A; Ferretti, ME; Scatturin, A; Spisani, S; Traniello, S; Vertuani, G | 1 |
| Lucente, G; Mollica, A; Nalli, M; Pagani Zecchini, G; Paglialunga Paradisi, M; Spisani, S | 1 |
| Cavicchioni, G; Spisani, S; Turchetti, M | 1 |
| Ko, HH; Lin, CN; Liu, CT; Tsao, LT; Wang, JP; Yu, KL | 1 |
| Falzarano, MS; Formaggio, F; Spisani, S; Toniolo, C; Witkowska, R; Zabrocki, J | 1 |
| Gavuzzo, E; Giordano, C; Lucente, G; Mazza, F; Mollica, A; Nalli, M; Pagani Zecchini, G; Paglialunga Paradisi, M; Spisani, S | 1 |
| Cavicchioni, G; Falzarano, S; Fraulini, A; Pavan, B; Spisani, S; Turchetti, M; Varani, K | 1 |
| Chiesa, ME; Elola, MT; Fink, NE | 1 |
| Chiu, PH; Hung, CF; Lin, CN; Wang, JP; Wei, BL; Weng, JR | 1 |
| Lucente, G; Mollica, A; Paradisi, MP; Spisani, S; Varani, K | 1 |
| Giordano, C; Lucente, G; Paradisi, MP; Sansone, A; Spisani, S; Torino, D | 1 |
| Falzarano, S; Franceschetti, L; Guerrini, R; Mollica, A; Selvatici, R; Siniscalchi, A; Spisani, S | 1 |
| Feliciani, F; Lucente, G; Mollica, A; Pinnen, F; Spisani, S; Torino, D | 1 |
| Costante, R; Feliciani, F; Lucente, G; Mollica, A; Notaristefano, D; Pinnen, F; Spisani, S; Stefanucci, A | 1 |
1 trial(s) available for n-formylmethionine leucyl-phenylalanine and muramidase
| Article | Year |
|---|---|
In vivo stimulation of neutrophil function by lenograstim (glycosylated rHuG-CSF) in oncohematologic patients: results of a phase I trial.
Topics: Adult; Cell Adhesion; Chemotaxis, Leukocyte; Female; Granulocyte Colony-Stimulating Factor; Granulocytes; Hodgkin Disease; Humans; In Vitro Techniques; Lenograstim; Leukocyte Count; Leukocyte Elastase; Lymphoma; Lymphoma, Non-Hodgkin; Male; Middle Aged; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neoplasms; Neutrophils; Pancreatic Elastase; Phagocytosis; Recombinant Proteins | 1994 |
145 other study(ies) available for n-formylmethionine leucyl-phenylalanine and muramidase
| Article | Year |
|---|---|
Signal transduction mechanisms of C1q-mediated superoxide production. Evidence for the involvement of temporally distinct staurosporine-insensitive and sensitive pathways.
Topics: Alkaloids; Calcium; Cell Degranulation; Cells, Cultured; Complement C1q; Glucuronidase; Humans; In Vitro Techniques; Macrophage-1 Antigen; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Respiratory Burst; Signal Transduction; Staurosporine; Superoxides; Time Factors; Transcobalamins | 1992 |
Protein-tyrosine phosphorylations induced by concanavalin A and N-formyl-methionyl-leucyl-phenylalanine in human neutrophils.
Topics: Blood Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Concanavalin A; Humans; Immunoblotting; Kinetics; Molecular Weight; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphorylation; Protein Kinases; Tyrosine; Virulence Factors, Bordetella | 1992 |
New chemotactic peptide analogs with high biological activity for human neutrophils.
Topics: Amino Acid Sequence; Chemotaxis, Leukocyte; Humans; In Vitro Techniques; Molecular Sequence Data; Molecular Structure; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Conformation; Receptors, Formyl Peptide; Receptors, Immunologic; Signal Transduction; Superoxides | 1992 |
Priming of human neutrophil functions by tumor necrosis factor: enhancement of superoxide anion generation, degranulation, and chemotaxis to chemoattractants C5a and F-Met-Leu-Phe.
Topics: Chemotaxis, Leukocyte; Complement C5a; Cytoplasmic Granules; Drug Synergism; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen; Peroxidase; Recombinant Proteins; Respiratory Burst; Superoxides; Tumor Necrosis Factor-alpha | 1992 |
Mepacrine inhibits fMLP-induced activation of human neutrophil granulocytes, leukotriene B4 formation, and fMLP binding.
Topics: Cell Degranulation; Cytochalasin B; Glucuronidase; Humans; In Vitro Techniques; Leukotriene B4; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Quinacrine; Receptors, Formyl Peptide; Receptors, Immunologic; Superoxides | 1992 |
Effect of adenylate cyclase activators on C5a-induced human neutrophil aggregation, enzyme release and superoxide production.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Cell Aggregation; Complement C5a; Cyclic AMP; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Epinephrine; Humans; In Vitro Techniques; Isoproterenol; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Prostaglandins E; Radioimmunoassay; Superoxides | 1992 |
Bone marrow matrix promotes differentiation and prolongs the cell cycle of U-937 cells.
Topics: Bone Marrow; Cell Adhesion; Cell Communication; Cell Cycle; Cell Differentiation; Cell Line; Extracellular Matrix; Humans; Lymphoma, Large B-Cell, Diffuse; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Receptors, Formyl Peptide; Receptors, Immunologic | 1992 |
Staurosporine clamps cytosolic free Ca2+ concentrations of human neutrophils.
Topics: Alkaloids; Calcium; Cytosol; Fura-2; Glucuronidase; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Ionomycin; Kinetics; Lysosomes; Manganese; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Protein Kinase C; Spectrometry, Fluorescence; Staurosporine; Virulence Factors, Bordetella | 1992 |
Platelet activation by fMLP-stimulated polymorphonuclear leukocytes: the activity of cathepsin G is not prevented by antiproteinases.
Topics: Blood Platelets; Calcium; Catalase; Cathepsin G; Cathepsins; Cytochrome Reductases; Glucuronidase; Humans; Kinetics; Lysosomes; Microscopy, Electron; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activation; Platelet Aggregation; Protease Inhibitors; Serine Endopeptidases; Superoxide Dismutase; Superoxides; Thromboxane B2 | 1991 |
Roles of Ca2+ in human neutrophil responses to receptor agonists.
Topics: Calcium; Cell Degranulation; Glucuronidase; Humans; In Vitro Techniques; Leukotriene B4; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, Formyl Peptide; Receptors, G-Protein-Coupled; Receptors, Immunologic; Receptors, Leukotriene B4; Signal Transduction; Superoxides; Temperature; Time Factors | 1991 |
Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation.
Topics: Bucladesine; Calcium; Cell Aggregation; Cell Differentiation; Complement C5a; Cyclosporine; Cyclosporins; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Glucuronidase; Humans; In Vitro Techniques; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Formyl Peptide; Receptors, Immunologic; Superoxides; Time Factors; Tumor Cells, Cultured | 1991 |
Concentration-dependent regulatory effects of prostaglandin E1 on human neutrophil function in vitro.
Topics: Alprostadil; Chemotaxis, Leukocyte; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peroxidase; Superoxides; Tetradecanoylphorbol Acetate | 1991 |
Tumor necrosis factor-alpha regulates expression of receptors for formyl-methionyl-leucyl-phenylalanine, leukotriene B4, and platelet-activating factor. Dissociation from priming in human polymorphonuclear neutrophils.
Topics: Cell Degranulation; Humans; In Vitro Techniques; Leukotriene B4; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, Formyl Peptide; Receptors, G-Protein-Coupled; Receptors, Immunologic; Receptors, Leukotriene B4; Tumor Necrosis Factor-alpha; Up-Regulation | 1991 |
Differential effect of diltiazem and TA-3090 on calcium homeostasis of neutrophils.
Topics: Calcium; Calcium Channel Blockers; Cytochalasin B; Diltiazem; Homeostasis; Humans; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Second Messenger Systems; Superoxides; Thiazepines | 1991 |
Adrenergic modulation of human polymorphonuclear leukocyte activation. Potentiating effect of adenosine.
Topics: Adenosine; Cell Adhesion; Cyclic AMP; Drug Synergism; Endothelium, Vascular; Epinephrine; Glucuronidase; Humans; Kinetics; Luminescent Measurements; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Purinergic; Superoxides | 1991 |
Relationship between arachidonate release and exocytosis in permeabilized human neutrophils stimulated with formylmethionyl-leucyl-phenylalanine (fMetLeuPhe), guanosine 5'-[gamma-thio]triphosphate (GTP[S]) and Ca2+.
Topics: Adenosine Triphosphate; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Membrane Permeability; Exocytosis; Glucuronidase; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils | 1991 |
Neutral endopeptidase activity in the interaction of N-formyl-L-methionyl-L-leucyl-L-phenylalanine with human polymorphonuclear leukocytes.
Topics: Amino Acid Sequence; Cell Membrane; Chemotaxis, Leukocyte; Humans; Hydrolysis; Light; Molecular Sequence Data; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neprilysin; Neutrophils; Scattering, Radiation | 1991 |
Differential inhibition by nedocromil sodium of superoxide generation elicited by platelet activating factor in human neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Calcium; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Nedocromil; Neutrophils; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Quinolones; Superoxides | 1990 |
Superoxide production by wound neutrophils. Evidence for increased activity of the NADPH oxidase.
Topics: Animals; Blood; Cytochrome b Group; Dose-Response Relationship, Drug; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Rabbits; Skin; Spectrum Analysis; Stimulation, Chemical; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Development of specific functionally active receptors for platelet-activating factor in HL-60 cells following granulocytic differentiation.
Topics: Acetylglucosaminidase; Binding, Competitive; Cell Differentiation; Cytochalasin B; Dimethyl Sulfoxide; Granulocytes; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tumor Cells, Cultured | 1990 |
Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides.
Topics: Dose-Response Relationship, Drug; Drug Synergism; Exocytosis; GTP-Binding Proteins; Humans; In Vitro Techniques; Lipoproteins; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Platelet Activating Factor; Structure-Activity Relationship; Superoxides; Tumor Necrosis Factor-alpha | 1990 |
Cocaine and its derivatives blunt neutrophil functions without influencing phosphorylation of a 47-kilodalton component of the reduced nicotinamide-adenine dinucleotide phosphate oxidase.
Topics: Anesthetics, Local; Calcimycin; Cell Aggregation; Cell Degranulation; Cocaine; Glucuronidase; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; Neutrophils; Receptors, Complement; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Up-Regulation | 1990 |
Polymeric analogues of N-formyl peptides are potent activators of degranulation and superoxide production by human neutrophils.
Topics: Cell Degranulation; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Structure-Activity Relationship; Superoxides | 1990 |
Potential roles of Mg2+ and Ca2+ in NADPH oxidase dependent superoxide anion synthesis by human neutrophils.
Topics: Calcimycin; Calcium; Cells, Cultured; Humans; Magnesium; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Identification of a cell-surface glycoprotein mediating adhesion in human granulocytes.
Topics: Antibodies, Monoclonal; Antigens, Surface; Calcimycin; Cell Adhesion; Cell Aggregation; Epitopes; Glycoproteins; Granulocytes; Humans; Immunoglobulin Fab Fragments; Membrane Proteins; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Phorbol Esters; Precipitin Tests; Superoxides | 1985 |
Inhibition of human neutrophil activation by the allergic mediator release inhibitor, CI-922: differential inhibition of responses to a variety of stimuli.
Topics: Azoles; Cell Movement; Chemotaxis, Leukocyte; Histamine Release; Humans; Hydrogen Peroxide; Indoles; Kinetics; Lysosomes; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidation-Reduction; Peroxidase; Phosphatidylinositols; Superoxides; Tetrazoles | 1987 |
Cellular effects of aprotinin.
Topics: Aprotinin; Cell Aggregation; Cell Division; Endotoxins; Fibroblasts; Granulocytes; Humans; In Vitro Techniques; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Pancreatic Elastase; Superoxides; Zymosan | 1987 |
Substance P activates and modulates neutrophil oxidative metabolism and aggregation.
Topics: Cell Aggregation; Dose-Response Relationship, Drug; Glucuronidase; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidation-Reduction; Oxygen; Peptide Fragments; Substance P | 1989 |
Exocytotic enzyme release from rabbit polymorphonuclear leukocytes after treatment with fluoride and calcium.
Topics: Adenosine Triphosphate; Animals; Calcimycin; Calcium; Calcium Radioisotopes; Exocytosis; Glyceric Acids; Glycogen; Glycolysis; L-Lactate Dehydrogenase; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Rabbits; Sodium Fluoride; Tetradecanoylphorbol Acetate | 1989 |
Fluoride activation of neutrophils: similarities to formylmethionyl-leucyl-phenylalanine.
Topics: Calcium; Cholera Toxin; Cytochalasin B; Fluorides; Humans; In Vitro Techniques; Kinetics; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Superoxides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1989 |
Effects of non-steroidal anti-inflammatory drugs on isolated human polymorphonuclear leukocytes (PMN): chemotaxis, superoxide production, degranulation and N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) receptor binding.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemotaxis, Leukocyte; Cytoplasmic Granules; Glucuronidase; Humans; In Vitro Techniques; L-Lactate Dehydrogenase; Lactoferrin; Meclofenamic Acid; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Formyl Peptide; Receptors, Immunologic; Superoxides; Tolmetin | 1989 |
Protease-modulation of neutrophil superoxide response.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Cathepsin G; Cathepsins; Chymotrypsin; Drug Combinations; Humans; Kinetics; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pancreatic Elastase; Peptide Hydrolases; Serine Endopeptidases; Superoxides; Tetradecanoylphorbol Acetate | 1989 |
Desensitization of calcium mobilization and cell function in human neutrophils.
Topics: Calcium; Cell Aggregation; Dose-Response Relationship, Drug; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Superoxides; Tetradecanoylphorbol Acetate | 1989 |
Inhibitory effects of methyl 7-butyl-4,5,6,7-tetrahydro-3-methylamino-4,6-dioxo-5-propyl- 2H-pyrazolo[3,4-d]pyrimidine-2-carboxylate (AA-2379) on lysosomal enzyme and arachidonic acid release from rat polymorphonuclear leukocytes and its mode of action.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Cyclic AMP; Glucuronidase; Lysosomes; Male; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pyrimidines; Rats; Rats, Inbred Strains; Zymosan | 1989 |
Some remarkable effects of thiopeptide and derived linkages on lysozyme release from neutrophils by esters of the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (f-Met-Leu-Phe-OR).
Topics: Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Structure-Activity Relationship; Sulfhydryl Compounds | 1989 |
Effect of an inhibitor of protein kinase C on human polymorphonuclear leukocyte degranulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate | 1987 |
Protein I, a translocatable ion channel from Neisseria gonorrhoeae, selectively inhibits exocytosis from human neutrophils without inhibiting O2- generation.
Topics: Benzofurans; Calcium; Cytochalasin B; Dose-Response Relationship, Drug; Exocytosis; Fura-2; Glucuronidase; Humans; Leukotriene B4; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neisseria gonorrhoeae; Nerve Tissue Proteins; Neutrophils; Superoxides; Synapsins | 1988 |
Intracellular location of T200 and Mo1 glycoproteins in human neutrophils.
Topics: Antigens, Differentiation; Antigens, Surface; Blood Proteins; Calcimycin; Cell Membrane; Cytochalasin B; Cytoplasmic Granules; Flow Cytometry; Gelatinases; Glucuronidase; Histocompatibility Antigens; Humans; Immunosorbent Techniques; Leukocyte Common Antigens; Macrophage-1 Antigen; Membrane Glycoproteins; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Organoids; Pepsin A; Temperature | 1988 |
Activation of the human neutrophil by calcium-mobilizing ligands. II. Correlation of calcium, diacyl glycerol, and phosphatidic acid generation with superoxide anion generation.
Topics: Calcium; Concanavalin A; Diglycerides; Ethers; Glucuronidase; Glycerides; Glycine; Humans; Ionomycin; Leukotriene B4; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidic Acids; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Protein Kinase C; Superoxides | 1988 |
Abnormal membrane fluidity as a cause of impaired functional dynamics of chemoattractant receptors on neonatal polymorphonuclear leukocytes: lack of modulation of the receptors by a membrane fluidizer.
Topics: 1-Propanol; Adult; Chemotaxis, Leukocyte; Child; Child, Preschool; Glucuronidase; Humans; Infant; Infant, Newborn; Membrane Fluidity; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Formyl Peptide; Receptors, Immunologic; Superoxides | 1988 |
Effect of defibrotide on polymorphonuclear leukocytes: modulation of calcium entry and availability.
Topics: Biological Availability; Calcimycin; Calcium; Fibrinolytic Agents; Free Radicals; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Polydeoxyribonucleotides; Superoxides; Tetradecanoylphorbol Acetate | 1988 |
Pertussis toxin inhibits human neutrophil responses mediated by the 42-kilodalton IgG Fc receptor.
Topics: Adenosine Diphosphate Ribose; Binding, Competitive; Cytoplasmic Granules; Glucuronidase; Humans; Immunoglobulin G; Intracellular Fluid; Molecular Weight; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phagocytosis; Receptors, Fc; Receptors, IgG; Virulence Factors, Bordetella | 1988 |
Regulation of neutrophil superoxide production in sepsis.
Topics: Abdomen; Adult; Aged; Bacterial Infections; Chemotaxis, Leukocyte; Complement C5; Complement C5a; Cytochalasin B; Female; Glucuronidase; Humans; Male; Middle Aged; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Postoperative Complications; Superoxides; Zymosan | 1985 |
Phorbol esters inhibit the fMet-Leu-Phe- and leukotriene B4-stimulated calcium mobilization and enzyme secretion in rabbit neutrophils.
Topics: Acetylglucosaminidase; Animals; Calcimycin; Calcium; Cytoplasmic Granules; Leukotriene B4; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbols; Rabbits; Sodium; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate | 1985 |
[Effects of pepstatin A on neutrophils; cross-deactivation with FMLP].
Topics: Binding, Competitive; Chemotaxis, Leukocyte; Cytochalasin B; Cytochrome c Group; Glucuronidase; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Pepstatins; Receptors, Formyl Peptide; Receptors, Immunologic; Superoxides | 1985 |
Stimulus-specific neutrophil aggregation: evaluation of possible mechanisms for the stimulus-response apparatus.
Topics: Calcimycin; Cell Aggregation; Cytoskeleton; Humans; Hydrogen Peroxide; In Vitro Techniques; Leukotriene B4; Microtubules; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen; Peroxidase; Prostaglandin-Endoperoxide Synthases; Time Factors; Zymosan | 1985 |
An objective filter-based, enzymatic method for the in vivo measurement of the migration of human polymorphonuclear leucocytes.
Topics: Adult; Blister; Chemotaxis, Leukocyte; Collodion; Filtration; Humans; Immunologic Techniques; Kinetics; Male; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peroxidase; Polyethylene Glycols | 1985 |
Inhibition of human neutrophil degranulation by forskolin in the presence of phosphodiesterase inhibitors.
Topics: Alprostadil; Calcimycin; Colforsin; Cyclic AMP; Cytoplasmic Granules; Glucuronidase; Humans; In Vitro Techniques; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphodiesterase Inhibitors; Radioimmunoassay; Time Factors | 1986 |
Differences among primates in defence against infection: sensitivity of polymorphonuclear leukocytes to fMet-Leu-Phe.
Topics: Animals; Callitrichinae; Chemotaxis, Leukocyte; Exocytosis; Glucuronidase; Humans; Lysosomes; Macaca mulatta; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pan troglodytes; Peroxidase; Primates | 1985 |
The effects of adenosine agonists on human neutrophil function.
Topics: Adenosine; Cytoplasmic Granules; Exocytosis; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Purinergic; Superoxides; Theophylline | 1986 |
Desensitization and antagonism of rat polymorphonuclear leukocytes stimulated with PAF acether.
Topics: Animals; Cells, Cultured; Cytochalasin B; Diterpenes; Exocytosis; Ginkgolides; Glucuronidase; Lactones; Leukotriene B4; Male; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Plant Extracts; Platelet Activating Factor; Pyridines; Rats; Rats, Inbred Strains; Thiazoles | 1987 |
Inhibition by nonsteroidal anti-inflammatory drugs of superoxide production and granule enzyme release by polymorphonuclear leukocytes stimulated with immune complexes or formyl-methionyl-leucyl-phenylalanine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antigen-Antibody Complex; Gelatinases; Glucuronidase; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pepsin A; Peroxidase; Superoxides | 1987 |
In vitro and in vivo effects of treatment by platelet-activating factor on N-formyl-met-leu-phe-mediated responses of polymorphonuclear leucocytes.
Topics: Animals; Granulocytes; Humans; Leukocyte Count; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rabbits; Superoxides | 1987 |
Protamine sulfate-induced enzyme secretion from rabbit neutrophils.
Topics: Animals; Calcimycin; Exocytosis; In Vitro Techniques; Kinetics; L-Lactate Dehydrogenase; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neuraminidase; Neutrophils; Protamines; Rabbits; Tetradecanoylphorbol Acetate | 1986 |
Platelet-leukocyte interaction: activation of rabbit platelets by FMLP-stimulated neutrophils.
Topics: Acetylglucosaminidase; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Female; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Rabbits | 1987 |
The effect of apomorphine on exocytosis and metabolic burst of polymorphonuclear leukocytes.
Topics: Adenosine Triphosphate; Animals; Apomorphine; Calcimycin; Exocytosis; In Vitro Techniques; L-Lactate Dehydrogenase; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitroblue Tetrazolium; Rabbits; Sulfhydryl Compounds; Tetradecanoylphorbol Acetate | 1987 |
Felodipine-induced inhibition of polymorphonuclear leukocyte functions.
Topics: Animals; Calcium; Calcium Channel Blockers; Chemotaxis, Leukocyte; Erythrocytes; Exocytosis; Felodipine; Humans; Kinetics; L-Lactate Dehydrogenase; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitrendipine; Nitroblue Tetrazolium; Prenylamine; Rabbits | 1988 |
Osmotic forces are not critical for Ca2+-induced secretion from permeabilized human neutrophils.
Topics: Calcium; Cell Membrane Permeability; Cytoplasmic Granules; Digitonin; Glucuronidase; Humans; Kinetics; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Osmolar Concentration; Transcobalamins | 1988 |
Effects of cytochalasin B, N-formyl peptide and plasma on polarisation, zeiosis (blebbing) and degranulation of polymorphonuclear leukocytes in suspension.
Topics: Blood; Cytochalasin B; Cytoplasm; Cytoplasmic Granules; Glucuronidase; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils | 1988 |
Decreased extracellular release of granule enzymes from in vitro-stimulated polymorphonuclear leukocytes in guttate psoriasis.
Topics: Cells, Cultured; Chemotaxis, Leukocyte; Complement C3; Cytoplasmic Granules; Eczema; Glucuronidase; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Photosensitivity Disorders; Psoriasis; Zymosan | 1986 |
Studies on the structural requirements for synthetic formyl peptide chemoattractants.
Topics: Humans; Lysosomes; Molecular Weight; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Formyl Peptide; Receptors, Immunologic; Structure-Activity Relationship | 1986 |
Characterization of lithium-induced enzyme release from human polymorphonuclear leukocytes.
Topics: Enzyme Activation; Humans; Lithium; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Virulence Factors, Bordetella | 1986 |
Retro-all-D and retro isomers of a formyl-methionyl peptide chemoattractant: an insight into the mode of binding at the receptor on rabbit neutrophils.
Topics: Animals; Chemotaxis, Leukocyte; Kinetics; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Rabbits; Receptors, Formyl Peptide; Receptors, Immunologic; Stereoisomerism; Structure-Activity Relationship | 1986 |
Response of human neutrophils to formyl-peptide modified at the terminal amino and carboxyl groups.
Topics: Chemotaxis, Leukocyte; Humans; In Vitro Techniques; Kinetics; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Structure-Activity Relationship | 1986 |
Beta-adrenergic blockade: augmentation of neutrophil-mediated inflammation.
Topics: Alprenolol; Animals; Cell Adhesion; Cell Aggregation; Cell Movement; Chemotaxis, Leukocyte; Glucuronidase; Humans; In Vitro Techniques; Inflammation; Lysosomes; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Propranolol; Rabbits; Receptors, Formyl Peptide; Receptors, Immunologic | 1987 |
Short-chain fatty acids produced by anaerobic bacteria alter the physiological responses of human neutrophils to chemotactic peptide.
Topics: Bacteria, Anaerobic; Cell Membrane; Chemotaxis, Leukocyte; Fatty Acids, Volatile; Humans; Luminescent Measurements; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils | 1987 |
Polymorphonuclear leucocytes as a model of Ca++ and Mg++-dependent cellular activation. Effect of calcium entry blockers.
Topics: Calcimycin; Calcium; Calcium Channel Blockers; Cell Aggregation; Cinnarizine; Flunarizine; Glucuronidase; Humans; Kinetics; Magnesium; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nifedipine | 1985 |
A highly active chemotactic peptide analog incorporating the unusual residue 1-aminocyclohexanecarboxylic acid at position 2.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Cyclohexanecarboxylic Acids; Magnetic Resonance Spectroscopy; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Rabbits; Structure-Activity Relationship | 1985 |
Effects of soluble stimuli on human monocyte secretion.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetylglucosaminidase; Cycloheximide; Dipeptides; Gallic Acid; Humans; Monocytes; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Demonstration of receptor-mediated chemotaxis by human spermatozoa. A novel quantitative bioassay.
Topics: Biological Assay; Chemotactic Factors; Chemotaxis; Chemotaxis, Leukocyte; Humans; Male; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Receptors, Formyl Peptide; Receptors, Immunologic; Spermatozoa; Structure-Activity Relationship | 1985 |
Phorbol myristate acetate enhances human polymorphonuclear neutrophil release of granular enzymes but inhibits chemokinesis.
Topics: Calcium; Chemotaxis, Leukocyte; Cytoplasm; Cytoplasmic Granules; Glucuronidase; Humans; In Vitro Techniques; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Rat neutrophil activation and effects of lipoxygenase and cyclooxygenase inhibitors.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Antigen-Antibody Complex; Antioxidants; Calcimycin; Catechols; Cyclooxygenase Inhibitors; Cytochalasin B; Ibuprofen; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piroxicam; Pyrazoles; Pyrazolones; Rats; Superoxides; Tetradecanoylphorbol Acetate; Thiazines; Zymosan | 1984 |
Neutrophil cytoplasts: relationships of superoxide release and calcium pools.
Topics: Cell Fractionation; Cell Nucleus; Centrifugation, Density Gradient; Chlortetracycline; Cytochalasin B; Fluorescence; Glucuronidase; Humans; Ion Channels; L-Lactate Dehydrogenase; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peroxidase; Superoxides | 1984 |
Inhibition of neutrophil activation by nonsteroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Cell Aggregation; Humans; Ibuprofen; In Vitro Techniques; Indomethacin; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piroxicam; Prostaglandin Antagonists; Superoxides; Thiazines | 1984 |
N-Formylmethionyl-leucyl-phenylalanine: Different releasing effects on human neutrophils and rat mast cells.
Topics: Acetylcholine; Animals; Chemotactic Factors; Glucuronidase; Histamine Release; Humans; Male; Mast Cells; Methionine; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Rats; Rats, Inbred Strains | 1983 |
Autacoid and beta-adrenergic agonist modulation of N-formylmethionyl-leucyl-phenylalanine evoked lysosomal enzyme release from human neutrophils.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Adult; Alprostadil; Autacoids; Calcimycin; Glucuronidase; Histamine; Humans; In Vitro Techniques; Lysosomes; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Prostaglandins E | 1984 |
Correlation of human neutrophil secretion, chemoattractant receptor mobilization, and enhanced functional capacity.
Topics: 1-Butanol; Butanols; Calcimycin; Calcium; Chemotaxis, Leukocyte; Cycloheximide; Cytoplasmic Granules; Granulomatous Disease, Chronic; Humans; Hydrogen Peroxide; Lactoferrin; Methionine; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Pinocytosis; Puromycin; Receptors, Immunologic; Superoxides; Tetradecanoylphorbol Acetate | 1982 |
Monocyte aggregation and superoxide anion release in response to formyl-methionyl-leucyl-phenylalanine (FMLP) and platelet-activating factor (PAF).
Topics: Calcium; Cell Aggregation; Cytochalasin B; Deoxyglucose; Humans; Iodoacetates; Iodoacetic Acid; Lysophosphatidylcholines; Magnesium; Methionine; Monocytes; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Oligopeptides; Oxygen; Platelet Activating Factor; Superoxides | 1982 |
Dissociation by piroxicam of degranulation and superoxide anion generation from decrements in chlortetracycline fluorescence of activated human neutrophils.
Topics: Analgesics; Cell Aggregation; Chemotactic Factors; Chlortetracycline; Concanavalin A; Humans; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Oxygen; Piroxicam; Pyridines; Spectrometry, Fluorescence; Superoxides; Tetradecanoylphorbol Acetate; Thiazines | 1982 |
The effect of various stimuli and calcium antagonists on the fluorescence response of chlorotetracycline-loaded human neutrophils.
Topics: Calcium; Chlortetracycline; Concanavalin A; Egtazic Acid; Gallic Acid; Glucuronidase; Humans; Lysosomes; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Phorbols; Spectrometry, Fluorescence; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate; Trifluoperazine; Vasodilator Agents | 1982 |
Correlation of in vitro and in vivo effects of gold compounds on leukocyte function: possible mechanisms of action.
Topics: Animals; Anti-Inflammatory Agents; Auranofin; Aurothioglucose; Cell Aggregation; Cells, Cultured; Cytochalasin B; Glucose; Glucuronidase; Gold; Gold Sodium Thiomalate; Humans; Lactoferrin; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Peroxidase; Rabbits | 1982 |
Cannabinoid induced degranulation of rabbit neutrophils.
Topics: Analgesics; Animals; Cannabidiol; Cannabinoids; Chemotactic Factors; Cytochalasin B; Cytoplasmic Granules; Dronabinol; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Phenanthridines; Rabbits | 1982 |
Effect of 6,9-deepoxy-6,9-(phenylimino)-delta 6,8-prostaglandin 1(1) (U-60,257), an inhibitor of leukotriene synthesis, on human neutrophil function.
Topics: Calcimycin; Chemotaxis, Leukocyte; Cytochalasin B; Epoprostenol; Glucuronidase; Humans; Kinetics; Leukotriene B4; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Prostaglandins; Superoxides | 1982 |
Synthetic leukotriene B4 is a potent chemotaxin but a weak secretagogue for human PMN.
Topics: Acetylglucosaminidase; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Humans; Kinetics; Leukotriene B4; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Peroxidase | 1983 |
Characterization of the rat neutrophil formyl peptide chemotaxis receptor.
Topics: Acetylglucosaminidase; Animals; Chemotaxis, Leukocyte; Kinetics; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Protein Conformation; Rats; Receptors, Cell Surface; Receptors, Formyl Peptide; Superoxides; Time Factors | 1983 |
Chemoattractant receptor functions in human polymorphonuclear leukocytes are divergently altered by membrane fluidizers.
Topics: Alcohols; Cell Membrane; Chemotaxis, Leukocyte; Humans; Kinetics; Membrane Fluidity; Methionine; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Receptors, Cell Surface; Receptors, Formyl Peptide | 1982 |
Heparin inhibits FMLP and Con-A dependent activation of human polymorphonuclear leucocytes in vitro.
Topics: Calcimycin; Concanavalin A; Glucuronidase; Granulocytes; Heparin; Humans; Lymphocyte Activation; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Superoxides | 1983 |
The mechanism of action of the antiinflammatory agents dexamethasone and Auranofin in human polymorphonuclear leukocytes.
Topics: Auranofin; Aurothioglucose; Chlortetracycline; Cytochalasin B; Cytoplasmic Granules; Dexamethasone; Electrophoresis; Fluorescence; Gold; Humans; Lactoferrin; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Cell Surface; Receptors, Formyl Peptide; Superoxides | 1983 |
The comparative responses of human polymorphonuclear leukocytes obtained by counterflow centrifugal elutriation and Ficoll-Hypaque density centrifugation. I. Resting volume, stimulus-induced superoxide production, and primary and specific granule release.
Topics: Adult; Blood Sedimentation; Cell Count; Cell Separation; Centrifugation; Centrifugation, Density Gradient; Cytoplasmic Granules; Glucuronidase; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Superoxides | 1983 |
The formylpeptide chemotactic receptor on rabbit peritoneal neutrophils: change of receptor affinity and number by L-1-tosylamide-2-phenylethyl chloromethyl ketone (TPCK).
Topics: Amino Acid Chloromethyl Ketones; Animals; Kinetics; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Rabbits; Receptors, Cell Surface; Receptors, Formyl Peptide; Temperature; Tosylphenylalanyl Chloromethyl Ketone | 1983 |
Selective inhibition by phenytoin of chemotactic factor - stimulated neutrophil functions.
Topics: Animals; Chemotactic Factors; Chemotaxis, Leukocyte; Complement C5; Complement C5a; Dose-Response Relationship, Drug; Glucuronidase; Humans; L-Lactate Dehydrogenase; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peroxidase; Phenytoin; Sheep; Superoxides | 1984 |
Nicotine is chemotactic for neutrophils and enhances neutrophil responsiveness to chemotactic peptides.
Topics: Chemotaxis, Leukocyte; Complement C5; Cytoplasmic Granules; Dose-Response Relationship, Drug; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nicotine; Pancreatic Elastase; Peroxidase; Stimulation, Chemical; Superoxides | 1984 |
Reversible blockade of the respiratory burst in human neutrophils by a cleavable cross-linking agent.
Topics: Cross-Linking Reagents; Dithiothreitol; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen Consumption; Succinimides; Superoxides; Tetradecanoylphorbol Acetate | 1984 |
Receptor blockade as a mechanism of deactivation of human neutrophils by pepstatin and formyl-Met-Leu-Phe.
Topics: Binding, Competitive; Chemotaxis; Cyclic AMP; Cytoplasmic Granules; Glucuronidase; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Pepstatins; Receptors, Immunologic; Superoxides | 1984 |
In vitro inhibition of granulocyte function by timegadine, a new anti-inflammatory agent.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Glucuronidase; Guanidines; Humans; In Vitro Techniques; L-Lactate Dehydrogenase; Lipopolysaccharides; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Prostaglandin-Endoperoxide Synthases; Superoxides | 1984 |
Neutrophil dysfunction in sepsis. III. Degranulation as a mechanism for nonspecific deactivation.
Topics: Bacterial Infections; Biliary Tract Diseases; Chemotaxis, Leukocyte; Colonic Diseases; Cytoplasmic Granules; Duodenal Diseases; Glucuronidase; Humans; Intestinal Diseases; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Cell Surface; Receptors, Formyl Peptide | 1984 |
Female hormones reduce neutrophil responsiveness in vitro.
Topics: Dose-Response Relationship, Drug; Estradiol; Glucuronidase; Humans; Hypoxanthines; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Progesterone; Protein Binding; Superoxides; Time Factors; Xanthine Oxidase | 1984 |
5-L-hydroxy-6,8,11,14-eicosatetraenoate potentiates the human neutrophil degranulating action of platelet-activating factor.
Topics: Arachidonic Acids; Calcimycin; Complement C5; Complement C5a; Drug Synergism; Glucuronidase; Humans; Hydroxyeicosatetraenoic Acids; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Platelet Activating Factor; Time Factors | 1983 |
Age-related decline in lysosomal enzyme release from polymorphonuclear leukocytes after N-formyl-methionyl-leucyl-phenylalanine stimulation.
Topics: Adult; Aged; Aging; beta-Galactosidase; Female; Glucuronidase; Humans; Lysosomes; Male; Microchemistry; Middle Aged; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils | 1983 |
Diacylglycerols enhance human neutrophil degranulation responses: relevancy to a multiple mediator hypothesis of cell function.
Topics: Animals; Calcimycin; Cytoplasmic Granules; Diglycerides; Glycerides; Humans; Kinetics; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Rabbits; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1984 |
Cyclic tetrameric clusters of chemotactic peptides as superactive activators of lysozyme release from human neutrophils.
Topics: Chemical Phenomena; Chemistry; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils | 1984 |
Metabolic requirements for maintenance of the chlortetracycline-labeled pool of membrane-bound calcium in human neutrophils.
Topics: Adult; Calcium; Cell Membrane; Chlortetracycline; Concanavalin A; Ethylmaleimide; Glucuronidase; Glycolysis; Humans; Lysosomes; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidative Phosphorylation | 1983 |
Conformationally constrained chemotactic peptide analogs of high biological activity.
Topics: Animals; Chemotactic Factors; Glucuronidase; Lysosomes; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Conformation; Rabbits; Structure-Activity Relationship | 1984 |
Modulation of rabbit neutrophil chemotaxis by cytochalasin A. A comparison with other neutrophil functions.
Topics: Animals; Chemotaxis; Cytochalasins; Dithionitrobenzoic Acid; Dose-Response Relationship, Drug; Exocytosis; L-Lactate Dehydrogenase; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Rabbits | 1984 |
An evaluation of the relationship between arachidonic acid lipoxygenation and human neutrophil degranulation.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Arachidonic Acids; Calcimycin; Chromatography, Thin Layer; Cytochalasin B; Cytoplasmic Granules; Glucuronidase; Humans; Hydrazones; Kinetics; Lipoxygenase; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides | 1981 |
C3a-induced lysosomal enzyme secretion from human neutrophils: lack of inhibition by f met-leu-phe antagonists and inhibition by arachidonic acid antagonists.
Topics: Anaphylatoxins; Arachidonic Acid; Arachidonic Acids; Chemotaxis, Leukocyte; Complement C3; Complement C3a; Complement C5; Complement C5a; Cytochalasin B; Glucuronidase; Humans; In Vitro Techniques; Lysosomes; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Peptides | 1982 |
Effects of acid proteinase inhibitors on human neutrophil chemotaxis and lysosomal enzyme release. II. Bromphenacyl bromide and 1,2-epoxy-3-(p-nitrophenoxy)propane.
Topics: Acetophenones; Acid Phosphatase; Chemotaxis, Leukocyte; Dipeptides; Epoxy Compounds; Humans; Lysosomes; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitrophenols; Oligopeptides; Pepstatins; Protease Inhibitors | 1983 |
Mechanism of dexamethasone inhibition of chemotactic factor induced granulocyte aggregation.
Topics: Cell Aggregation; Chemotactic Factors; Cytochalasin B; Cytoplasmic Granules; Dexamethasone; Endothelium; Glucuronidase; Granulocytes; Humans; In Vitro Techniques; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Oligopeptides; Tetradecanoylphorbol Acetate | 1982 |
Degranulation, membrane addition, and shape change during chemotactic factor-induced aggregation of human neutrophils.
Topics: Cell Adhesion; Cell Aggregation; Cell Membrane; Chemotaxis, Leukocyte; Exocytosis; Humans; Intracellular Membranes; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides | 1982 |
Further studies on the structural requirements for synthetic peptide chemoattractants.
Topics: Animals; Biological Assay; Chemotaxis; Cytochalasin B; Glucuronidase; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Rabbits; Structure-Activity Relationship | 1980 |
Development of specific receptors for N-formylated chemotactic peptides in a human monocyte cell line stimulated with lymphokines.
Topics: Binding Sites; Binding, Competitive; Cell Line; Chemotactic Factors; Chemotaxis, Leukocyte; Glucuronidase; Humans; Kinetics; Lymphokines; Lysosomes; Methionine; Monocytes; Muramidase; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Oligopeptides; Receptors, Drug; Time Factors; Tritium | 1980 |
Regulation of N-formyl-methionyl-leucyl-phenylalanine receptor recycling by surface membrane neutral endopeptidase-mediated degradation of ligand.
Topics: Amino Acid Sequence; Antibodies; Cell Membrane; Cytoplasmic Granules; Down-Regulation; Glycopeptides; Humans; Leukocyte Elastase; Ligands; Molecular Sequence Data; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neprilysin; Neutrophils; Pancreatic Elastase; Protease Inhibitors; Receptors, Complement 3b; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Up-Regulation | 1995 |
Modulation of rat peripheral polymorphonuclear leukocyte response by nitric oxide and arginine.
Topics: Animals; Arachidonic Acid; Arginine; Free Radicals; Hydroxyl Radical; Luminescent Measurements; Luminol; Male; Malondialdehyde; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Peroxidase; Rats; Rats, Sprague-Dawley; Superoxides; Tetradecanoylphorbol Acetate | 1994 |
Effects of dirithromycin and erythromycylamine on human neutrophil degranulation.
Topics: Anti-Bacterial Agents; Biomarkers; Cell Degranulation; Erythromycin; Glucuronidase; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Macrolides; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils | 1994 |
N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions.
Topics: Carbazoles; Enzyme Activation; Humans; In Vitro Techniques; Indoles; Isoenzymes; Maleimides; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate | 1994 |
Effect of xanthine derivatives on chemotactic polypeptide-induced superoxide and enzyme release from human polymorphonuclear leucocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Adenosine Deaminase; Chemotaxis, Leukocyte; Humans; Male; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Purinergic P1 Receptor Antagonists; Superoxides; Xanthines | 1993 |
Inhibition of neutrophil function in vitro by nimesulide. Preliminary evidence of an adenosine-mediated mechanism.
Topics: Adenosine; Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Calcium; Free Radicals; Glucuronidase; Humans; In Vitro Techniques; Luminescent Measurements; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Purinergic P1; Sulfonamides; Superoxides; Theophylline | 1993 |
Stimulation of human polymorphonuclear leukocytes by leukotriene B4 and platelet-activating factor: an ultrastructural and pharmacological study.
Topics: Acetylglucosaminidase; Adult; Cell Aggregation; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Ionomycin; Leukotriene B4; Lipoxygenase Inhibitors; Microscopy, Electron; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Quinolines | 1993 |
Immune complex-stimulated neutrophil LTB4 production is dependent on beta 2 integrins.
Topics: Actins; Antibodies, Monoclonal; Antigen-Antibody Complex; Calcium; Cell Adhesion; Cell Line; Humans; Immunoglobulin G; Kinetics; Leukotriene B4; Lymphocyte Function-Associated Antigen-1; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, IgG | 1993 |
Homologous priming in chemotactic peptide-stimulated neutrophils.
Topics: Calcium; Dose-Response Relationship, Drug; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Formyl Peptide; Receptors, Immunologic; Superoxides | 1993 |
Concanavalin A and mistletoe lectin I differentially activate cation entry and exocytosis in human neutrophils: lectins may activate multiple subtypes of cation channels.
Topics: Barium; Calcium; Cations, Divalent; Concanavalin A; Exocytosis; Female; Fluorescence; Humans; Ion Channels; Male; Metals; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Plant Preparations; Plant Proteins; Ribosome Inactivating Proteins, Type 2; Signal Transduction; Sodium; Stimulation, Chemical; Strontium; Thapsigargin; Toxins, Biological | 1996 |
Complex regulation of human neutrophil activation by actin filaments: dihydrocytochalasin B and botulinum C2 toxin uncover the existence of multiple cation entry pathways.
Topics: Actins; Barium; Botulinum Toxins; Calcium; Cations; Cytochalasin B; Female; Humans; Ion Transport; Lectins; Male; Manganese; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Plant Preparations; Plant Proteins; Ribosome Inactivating Proteins, Type 2; Sodium; Strontium; Superoxides; Thapsigargin; Toxins, Biological | 1997 |
Inhibition of neutrophil oxidative burst and granule secretion by wortmannin: potential role of MAP kinase and renaturable kinases.
Topics: Androstadienes; Antigens, CD; Antigens, Neoplasm; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Cell Degranulation; Cells, Cultured; Chromones; Enzyme Inhibitors; Humans; MAP Kinase Kinase 1; Membrane Glycoproteins; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peroxidase; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet Membrane Glycoproteins; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate; Tetraspanin 30; Wortmannin | 1997 |
Lipoproteins of Treponema denticola: their effect on human polymorphonuclear neutrophils.
Topics: Antibodies; Autoradiography; Bacterial Proteins; Chemotactic Factors; Chromatography; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Endopeptidase K; Enzyme Inhibitors; Exocytosis; Fatty Acids; Glucuronidase; Humans; Indicators and Reagents; Lipopolysaccharides; Lipoproteins; Luminescent Measurements; Luminol; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Oleic Acid; Oligosaccharides; Palmitic Acid; Periodontal Diseases; Radiopharmaceuticals; Sodium Dodecyl Sulfate; Surface-Active Agents; Treponema; Tritium | 1997 |
Phosphatidylinositol 3-kinase mediates chemoattractant-stimulated, CD11b/CD18-dependent cell-cell adhesion of human neutrophils: evidence for an ERK-independent pathway.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; CD18 Antigens; Cell Adhesion; Cell Aggregation; Cell Line, Transformed; Chromones; Complement C5a; Endothelium, Vascular; Epitopes; Humans; Ionophores; Macrophage-1 Antigen; Morpholines; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphatidylinositol 3-Kinases; Tetradecanoylphorbol Acetate; Up-Regulation; Wortmannin | 1998 |
Cationic proteins of neutrophil azurophilic granules: protein-protein interaction and blockade of NADPH oxidase activation.
Topics: Cell Fractionation; Cell-Free System; Centrifugation, Density Gradient; Chromatography, Affinity; Chromatography, Gel; Cytoplasmic Granules; Cytosol; Enzyme Activation; Humans; Muramidase; Myeloblastin; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phenylmethylsulfonyl Fluoride; Respiratory Burst; Serine Endopeptidases; Superoxides; Tetradecanoylphorbol Acetate | 1998 |
Phe-D-Leu-Phe-D-Leu-Phe derivatives as formylpeptide receptor antagonists in human neutrophils: cellular and conformational aspects.
Topics: Binding, Competitive; Calcium; Circular Dichroism; Humans; Molecular Structure; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Protein Conformation; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Spectroscopy, Fourier Transform Infrared; Superoxides | 1999 |
[Effects of the glucoprotein component of musk on the functions of rat polymorphonuclear leukocytes activated by fMLP in vitro].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Fatty Acids, Monounsaturated; Female; Glucuronidase; Male; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Rats; Rats, Wistar; Superoxides | 1997 |
An evaluation of fMLP pocket dimensions and features using formyltetrapeptides.
Topics: Amino Acid Sequence; Chemotactic Factors; Chemotaxis, Leukocyte; Cytoplasmic Granules; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Structure-Activity Relationship; Superoxides | 1999 |
Depressant effects of ambroxol on lipopolysaccharide- or fMLP-stimulated free radical production and granule enzyme release by alveolar macrophages.
Topics: Acid Phosphatase; Ambroxol; Animals; Bacterial Toxins; Calcium; Cytoplasmic Granules; Depression, Chemical; Enterotoxins; Escherichia coli; Escherichia coli Proteins; Expectorants; Free Radicals; Hydrogen Peroxide; In Vitro Techniques; Lipopolysaccharides; Macrophages, Alveolar; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Nitrates; Nitrites; Oxidants; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Superoxides | 1999 |
A hydrophilic residue at position 2 can improve specific biological responses in fMLP-OMe analogs.
Topics: Amino Acid Substitution; Chemotaxis; Humans; In Vitro Techniques; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Superoxides | 2001 |
C- and N-terminal residue effect on peptide derivatives' antagonism toward the formyl-peptide receptor.
Topics: Amino Acid Sequence; Cell Movement; Chemotaxis; Dose-Response Relationship, Drug; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Protein Binding; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Superoxides | 2002 |
Isopeptide bonds in chemotactic tripeptides. Synthesis and activity of lysine-containing fMLF analogs.
Topics: Amino Acid Sequence; Chemotaxis; Humans; Lysine; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Structure-Activity Relationship; Superoxides | 2002 |
Biological variation responses in fMLP-OMe analogs, introducing bulky protecting groups on the side-chain of hydrophilic residues at position 2.
Topics: Chemotaxis, Leukocyte; Chromatography, Thin Layer; Humans; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Structure-Activity Relationship; Superoxides | 2002 |
Structure-activity relationship studies on chalcone derivatives. the potent inhibition of chemical mediators release.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Chalcone; Cytochalasin B; Glucuronidase; Histamine Release; Macrophages; Mast Cells; Mice; Microglia; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Structure-Activity Relationship; Superoxides | 2003 |
Synthetic formyl tripeptide chemoattractants: a C(alpha,alpha)-dialkylated, amphiphilic glycyl residue at position 1.
Topics: Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycine; Humans; Magnetic Resonance Spectroscopy; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Conformation; Superoxides | 2003 |
Hybrid alpha/beta3-peptides with proteinogenic side chains. Monosubstituted analogues of the chemotactic tripeptide For-Met-Leu-Phe-OMe.
Topics: Amino Acid Sequence; Chemotaxis, Leukocyte; Crystallization; Humans; Molecular Conformation; Molecular Sequence Data; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Structure-Activity Relationship; Superoxides; X-Ray Diffraction | 2004 |
Biological activity of for-Met-Leu-Phe-OMe analogs: relevant substitutions specifically trigger killing mechanisms in human neutrophils.
Topics: Binding, Competitive; Chemotaxis, Leukocyte; Cytotoxicity, Immunologic; Humans; In Vitro Techniques; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Radioligand Assay; Structure-Activity Relationship; Superoxides | 2005 |
Activation of oxidative burst and degranulation of porcine neutrophils by a homologous spleen galectin-1 compared to N-formyl-L-methionyl-L-leucyl-L-phenylalanine and phorbol 12-myristate 13-acetate.
Topics: Animals; Carbohydrate Sequence; Cell Degranulation; Galectin 1; Molecular Sequence Data; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Plant Preparations; Plant Proteins; Respiratory Burst; Ribosome Inactivating Proteins; Ribosome Inactivating Proteins, Type 2; Sequence Homology, Amino Acid; Spleen; Superoxides; Swine; Tetradecanoylphorbol Acetate; Toxins, Biological | 2005 |
Antiinflammatory flavonoids from Artocarpus heterophyllus and Artocarpus communis.
Topics: Animals; Anti-Inflammatory Agents; Artocarpus; Flavonoids; Glucuronidase; Macrophages; Mast Cells; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitric Oxide; Rats; Rats, Sprague-Dawley; Superoxides | 2005 |
Chemotactic peptides: fMLF-OMe analogues incorporating proline-methionine chimeras as N-terminal residue.
Topics: Cytoplasmic Granules; Humans; Magnetic Resonance Spectroscopy; Methionine; Molecular Conformation; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Proline; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2006 |
Chemotactic tripeptides incorporating at position 2 alpha-aminoacid residues with unsaturated side chains.
Topics: Allyl Compounds; Allylglycine; Carboxylic Acids; Chemotactic Factors; Cyclopentanes; Glycine; Humans; Magnetic Resonance Spectroscopy; Molecular Conformation; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Folding; Superoxides | 2008 |
Study of synthetic peptides derived from the PKI55 protein, a protein kinase C modulator, in human neutrophils stimulated by the methyl ester derivative of the hydrophobic N-formyl tripeptide for-Met-Leu-Phe-OH.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Brain; Cell Survival; Enzyme Activation; Humans; Hydrophobic and Hydrophilic Interactions; Isoenzymes; Molecular Sequence Data; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peptides; Protein Kinase C; Protein Kinase C beta; Proteins; Rats; Superoxides | 2008 |
Novel chemotactic For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on met residue replacement by 4-amino-proline scaffold: synthesis and bioactivity.
Topics: Amino Acid Sequence; Cells, Cultured; Chemotaxis; Humans; Ligands; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Proline; Superoxides | 2009 |
Synthesis and biological evaluation of new active For-Met-Leu-Phe-OMe analogues containing para-substituted Phe residues.
Topics: Amino Acid Sequence; Anions; Chemotaxis; Humans; Molecular Conformation; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Phenylalanine; Reference Values; Stereoisomerism; Superoxides | 2012 |