n-desmethylflunitrazepam has been researched along with flunitrazepam in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (21.43) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blair, T; Webb, GA | 1 |
| Aoyama, T; Ichikawa, H; Suzuki, Y | 1 |
| Lopata, A; Lukovits, I | 1 |
| Johnston, GA; Maddalena, DJ | 1 |
| Karplus, M; So, SS | 1 |
| Antoni, M; Cano, JP; Coassolo, P; Drouet-Coassolo, C; Iliadis, A | 1 |
| He, W; Parissis, N | 1 |
| Bochner, F; Coller, JK; Somogyi, AA | 1 |
| Greenblatt, DJ; Hesse, LM; Shader, RI; Venkatakrishnan, K; von Moltke, LL | 1 |
| Busto, UE; Gafni, I; Kaplan, HL; Sellers, EM; Tyndale, RF | 1 |
| Briellmann, TA; Dussy, FE; Hamberg, C | 1 |
| Hsieh, YZ; Huang, CW; Jen, HP; Wang, RD | 1 |
| Baud, FJ; Borron, SW; Bouchonnet, S; Debray, M; Declèves, X; Duarte, T; Megarbane, B; Milan, N; Perrin, B; Pirnay, S; Ricordel, I; Risède, P | 1 |
| Lukovits, I | 1 |
1 review(s) available for n-desmethylflunitrazepam and flunitrazepam
| Article | Year |
|---|---|
Neural networks applied to quantitative structure-activity relationship analysis.
Topics: Animals; Azirines; Benzodiazepines; Carbazilquinone; Nerve Net; Nervous System; Regression Analysis; Structure-Activity Relationship | 1990 |
13 other study(ies) available for n-desmethylflunitrazepam and flunitrazepam
| Article | Year |
|---|---|
Electronic factors in the structure-activity relationship of some 1,4-benzodiazepin-2-ones.
Topics: Benzodiazepinones; Electrochemistry; Structure-Activity Relationship | 1977 |
Decomposition of pharmacological activity indices into mutually independent components using principal component analysis.
Topics: Animals; Anti-Infective Agents; Benzodiazepines; Hydroxyquinolines; Mathematics; Pharmacology; Rifamycins; Seizures; Statistics as Topic; Structure-Activity Relationship | 1980 |
Prediction of receptor properties and binding affinity of ligands to benzodiazepine/GABAA receptors using artificial neural networks.
Topics: Binding Sites; Ligands; Neural Networks, Computer; Predictive Value of Tests; Receptors, GABA-A; Structure-Activity Relationship | 1995 |
Genetic neural networks for quantitative structure-activity relationships: improvements and application of benzodiazepine affinity for benzodiazepine/GABAA receptors.
Topics: Algorithms; Benzodiazepines; Models, Genetic; Nerve Net; Protein Binding; Receptors, GABA-A; Structure-Activity Relationship | 1996 |
Pharmacokinetics of flunitrazepam following single dose oral administration in liver disease patients compared with healthy volunteers.
Topics: Administration, Oral; Adult; Chromatography, Gas; Flunitrazepam; Half-Life; Hepatitis, Viral, Human; Humans; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged | 1990 |
Simultaneous determination of flunitrazepam and its metabolites in plasma and urine by HPLC/DAD after solid phase extraction.
Topics: Chromatography, High Pressure Liquid; Flunitrazepam; Humans; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet; Triazolam | 1997 |
Quantification of flunitrazepam's oxidative metabolites, 3-hydroxyflunitrazepam and desmethylflunitrazepam, in hepatic microsomal incubations by high-performance liquid chromatography.
Topics: Anti-Anxiety Agents; Calibration; Chromatography, High Pressure Liquid; Flunitrazepam; Humans; Microsomes, Liver; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1998 |
CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.
Topics: Anti-Anxiety Agents; Benzoflavones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Flunitrazepam; Humans; Hydroxylation; Isoenzymes; Ketoconazole; Kinetics; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Quinidine; Ritonavir; Sulfaphenazole; Transfection | 2001 |
The role of cytochrome P450 2C19 activity in flunitrazepam metabolism in vivo.
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Female; Flunitrazepam; Humans; Male; Middle Aged; Mixed Function Oxygenases | 2003 |
Quantification of benzodiazepines in whole blood and serum.
Topics: Anti-Anxiety Agents; Benzodiazepines; Chromatography, High Pressure Liquid; Flunitrazepam; Flurazepam; Forensic Toxicology; Humans; Mass Spectrometry; Midazolam; Molecular Structure; Serum | 2006 |
Sweeping technique combined with micellar electrokinetic chromatography for the simultaneous determination of flunitrazepam and its major metabolites.
Topics: Anti-Anxiety Agents; Buffers; Calibration; Cetrimonium; Cetrimonium Compounds; Chromatography, Micellar Electrokinetic Capillary; Flunitrazepam; Humans; Hydrogen-Ion Concentration; Reproducibility of Results; Sensitivity and Specificity | 2006 |
Buprenorphine alters desmethylflunitrazepam disposition and flunitrazepam toxicity in rats.
Topics: Analgesics, Opioid; Animals; Biotransformation; Buprenorphine; Carbon Dioxide; Drug Interactions; Flunitrazepam; GABA Modulators; Hydrogen-Ion Concentration; Infusions, Intravenous; Male; Oxygen; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley; Respiratory Insufficiency | 2008 |
Quantitative structure-activity relationships employing independent quantum chemical indices.
Topics: Amines; Benzodiazepines; Benzylamines; Mathematics; Quantum Theory; Structure-Activity Relationship; Tetracyclines | 1983 |